Permeated Liquid Quantity Measurement Or Control Patents (Class 210/321.65)
  • Patent number: 10336630
    Abstract: A reverse osmosis system and method includes a pump pressurizing a feed stream, a first and second membrane array that generates permeate and brine streams. A first energy recovery device uses first energy from the second brine stream to pressurize the first brine stream. A first and second auxiliary and bypass valves are associated with the first and second energy recovery device. A second energy recovery device uses second energy from the second brine stream to increase a second pressure of the feed stream. A first flowmeter generates a first flow signal for the first permeate stream. A second flowmeter generates a second flow signal for of the second permeate stream. A third flowmeter generates a third flow signal for the second brine stream. A motor drives the first energy recovery device. A controller controls the in response to the flow signals.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: July 2, 2019
    Assignee: Fluid Equipment Development Company, LLC
    Inventor: Eli Oklejas, Jr.
  • Patent number: 10325680
    Abstract: A user interface for a machine for extracorporeal blood treatment comprises a touch screen and a controller programmed to display on a screen (16) a display in which two distinct areas are arranged, one of which (161) exhibits a series of touch keys (17). Activation of any one touch key (17) causes visualization of an image in a second area (162) of the screen. The images are displayed alternatively and are at least partly different one from another. Each touch key (17) is associated to an instruction, or to a group of instructions, all concerned with readying the machine for use. Each image is a pictograph of a configuration of the machine, correlated with an instruction associated to the touch key (17) selected. The operator is aided in making the machine ready for treatment.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: June 18, 2019
    Assignee: Gambro Lundia AB
    Inventors: Lorenza Ferrarini, Danielle Pelletier, Massimo Zaccarelli, Jeffrey J. Letteri
  • Patent number: 10314965
    Abstract: A filtering device receives a signal from a pressure sensor in an extracorporeal fluid circuit connected to a subject and processes the signal to separate physiological pulses, e.g. from the subject's heart, from interference pulses, e.g. from a pump in the fluid circuit. The device repeatedly (iteratively) processes a signal segment by alternately subtracting (S3) a template signal from the signal segment, and applying a refinement processing (S6) to the resulting difference signal to generate a new template signal. By proper selection (S2) of the initial template signal, consecutive difference signals will alternately approximate the sequence of interference pulses in the signal segment and the sequence of physiological pulses in the signal segment. The refinement processing (S6) aims at alternately cleaning up unwanted residuals from interference pulses and physiological pulses, respectively, in the respective difference signal, so as to improve the accuracy of the template signal between the subtractions.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: June 11, 2019
    Assignee: GAMBRO LUNDIA AB
    Inventors: Mattias Holmer, Bo Olde, Kristian Solem, Leif Sornmo
  • Patent number: 10220133
    Abstract: The invention relates to a method of purging gas bubbles from a target zone of an extracorporeal blood circuit of a dialysis machine, wherein the target zone is flowed through by flushing liquid which enters into the target zone through an inflow and exits it again through an outflow, wherein the inflow differs from the arterial port and the outflow differs from the venous port of the extracorporeal blood circuit. The invention furthermore relates to a dialysis machine having an extracorporeal blood circuit and a control unit, with the extracorporeal blood circuit having an inflow and an outflow for flushing liquid, with the inflow differing from the arterial port and the outflow differing from the venous port of the extracorporeal blood circuit, and with the control unit being configured to carry out a method in accordance with the invention.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: March 5, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Ralf Wojke, Paul Wieneke
  • Patent number: 10201646
    Abstract: The present invention relates to an apparatus for the regulation of at least one filtration value in a machine for the treatment of a medical fluid, in particular in a blood treatment machine, having at least one centrifugal pumping means, to a hemodialysis machine and to a method and to a use therefor.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: February 12, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Arne Peters, Alexander Heide, Christoph Wiktor
  • Patent number: 10195319
    Abstract: An object of the invention is to provide a blood component separation device that can keep the concentration of anticoagulant in a predetermined blood component to a constant level to minimize aggregation of a predetermined blood component (for example, aggregation of platelets). One aspect of the present invention is a blood component separation device that separates the predetermined blood component from the blood drawn from a blood donor while supplying to the blood an anticoagulant for preventing coagulation of the blood, where an anticoagulant ratio, or a ratio of an amount of the anticoagulant supplied in relation to the blood, is set according to a hematocrit value of the blood donor so that a concentration of the anticoagulant in the predetermined blood component becomes a predetermined value.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: February 5, 2019
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Shigeyuki Kimura
  • Patent number: 10039875
    Abstract: A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: August 7, 2018
    Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Christopher DiBiasio, Daniel I. Harjes, Joseph L. Charest, Jeffrey T. Borenstein
  • Patent number: 9993773
    Abstract: An energy recovery system in a seawater desalination plant uses a reverse-osmosis membrane method for removing salinity from seawater. The system is configured to supply high-pressure water produced by pressurizing raw water with a high-pressure pump to a reverse-osmosis membrane cartridge, and to supply concentrated water discharged from the cartridge to an isobaric energy recovery device to recover pressure energy of the concentrated water whereby part of the raw water supplied to the isobaric energy recovery device is pressurized, and then to allow the pressurized raw water to merge into the high-pressure water pressurized by the high-pressure pump. The system includes a booster pump for boosting a pressure of the concentrated water discharged from the cartridge, and an energy recovery turbine for recovering energy by using the pressure head difference between the pressurized raw water from the isobaric energy recovery device and the high-pressure water discharged from the pump.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: June 12, 2018
    Assignee: EBARA CORPORATION
    Inventors: Akira Goto, Shigeo Takita
  • Patent number: 9974491
    Abstract: A method of detecting an indication of a potential intradialytic morbid event (IME) by monitoring a patient's condition during excess fluid removal by ultrafiltration during a hemodialysis treatment includes determining the patient's relative blood volume (RBV), and removing a portion of the volume of excess fluid from blood of the patient at an initial ultrafiltration rate while periodically monitoring a second derivative over time of the relative blood volume (SDRBV). The method then includes continuing to remove excess fluid from blood of the patient at the same ultrafilration rate, or, optionally, incrementally increasing the ultrafiltration rate. The method further includes triggering an alarm for an IME for the patient if the SDRBV is in a range of between a low SDRBV alarm level and a high SDRBV alarm level, and, alternatively or additionally monitoring the patient's normalized blood pressure ratio, and taking a remedial action if the alarm is triggered.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: May 22, 2018
    Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.
    Inventors: Fansan Zhu, Peter Kotanko, Stephan Thijssen, Nathan W. Levin
  • Patent number: 9914100
    Abstract: A dialysis concentrate production system includes a container and a stationary production system. The container comprises a discharge port and a combined port. The stationary production system comprises a storage container comprising a mixing inlet and an outlet, a delivery pump arranged downstream of the outlet, a first water jet pump arranged downstream of the delivery pump, and a second water jet pump arranged downstream of the delivery pump and parallel to the first water jet pump. The first water jet pump comprises a driving inlet in fluid communication with the delivery pump, a suction port in fluid communication with the combined port, and an outlet. The second water jet pump comprises a driving inlet in fluid communication with the delivery pump, a suction port in fluid communication with the discharge port, and an outlet in fluid communication with the mixing inlet.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: March 13, 2018
    Assignee: INTERMEDT MEDIZIN & TECHNIK GMBH
    Inventor: Christoph Dumschat
  • Patent number: 9849228
    Abstract: A method for determining at least one parameter of an extracorporeal blood circuit includes the steps of filling an extracorporeal blood circuit, e.g., encompassing a medical functional device, a treatment device and/or a blood tube set, by introducing a fluid, and detecting a volume of the introduced fluid which is required for filling the extracorporeal blood circuit by a detection device. A control device, a treatment apparatus, a computer readable storage medium, a computer program product as well as a computer program are also described.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: December 26, 2017
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Joachim Noack, Wei Zhang
  • Patent number: 9636447
    Abstract: A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: May 2, 2017
    Assignee: Gambro Lundia AB
    Inventors: Bo Olde, Kristian Solem, Mattias Holmer, Jan Sternby
  • Patent number: 9582164
    Abstract: An apparatus, method and computer program for performing a plurality of operation steps of a dialysis process is disclosed. In one embodiment, a process controller controls the apparatus to perform the operation steps, monitor the dialysis process and monitor sensor inputs of sensors of the apparatus. The apparatus further includes a user interface (“UI”), comprising a display, an input device and a UI controller, wherein the UI controller enables presentation of graphical data on the display, enables user interaction with the graphical data and exchanges information with the process controller. Each of the operation steps is classified as a sequential operation step or a non-sequential operation step. The UI controller, for each of the operation steps, dynamically controls enabling and disabling of interaction with displayed corresponding operation step items based on a state of the respective operation step (i.e., completed, non-completed, selectable, non-selectable).
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: February 28, 2017
    Assignee: Gambro Lundia AB
    Inventor: Anita Stenquist
  • Patent number: 9550020
    Abstract: A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump; first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: January 24, 2017
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
  • Patent number: 9415150
    Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: August 16, 2016
    Assignee: Baxter Healthcare S.A.
    Inventors: Michael E. Hogard, Donald D. Busby, Robert W. Childers, Yuanpang S. Ding, Katherine M. Holian, Mark E. Jablonski, Thomas D. Kelly, Ying-Cheng Lo, Shincy J. Maliekkal, Rodolfo G. Roger, Donald A. Smith, Atif M. Yardimci
  • Patent number: 9399857
    Abstract: A reader writer (communication device) executes at least one of reading identification information stored in an IC tag and writing the identification information to the IC tag. The reader writer includes: a wireless control circuit that generates output for communication; a temperature sensor (temperature detector) that detects a temperature in an environment in which an RFID chip, balun, filter circuit, power amplifier, and coupler (elements for forming the wireless control circuit) are used; a temperature judging unit that judges whether or not the environment in which the element is used falls within a usable temperature range of the element based on the temperature detected by the temperature sensor; and a wireless power supply controller that suppresses a supply of power to the wireless control circuit when the temperature judging unit judges that the element is not in the environment within the usable temperature range.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: July 26, 2016
    Assignee: Komatsu Ltd.
    Inventors: Shinpei Kawasaki, Motoi Ishidou, Yasushi Tsushimi
  • Patent number: 9240002
    Abstract: This disclosure describes systems and methods for a graphical interface including a graphical representation of medical data. The graphical interface platform may receive medical data and provide medical safety reporting capabilities including reporting of history data and real-time visual monitoring data. The graphical interface platform may be configured to identify potential problems and corrections to medical devices in operation while a reporting cycle is underway through visual representation of performance metrics.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: January 19, 2016
    Assignee: Hospira, Inc.
    Inventors: James A. Hume, Robert M. Hume, Robert Mayer, Devy Amy Lee, Gabriele Ott, Candida Arvelo, Timothy L. Ruchti, Tamas Ban, Mohammad M. Khair, Nancy H. Hedlund
  • Patent number: 8951419
    Abstract: A method and apparatus for the treatment of water and, more particularly, to the mineralization of water in order to improve pH, hardness, turbidity, and/or alkalinity is described. More particularly, a system is provided for the treatment of water that needs additional hardness, alkalinity, and/or pH adjustment while also meeting turbidity requirements. The use of sodium hydroxide and other methods for avoiding turbidity problems can be eliminated and/or minimized.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 10, 2015
    Assignee: Burnett Lime Company, Inc.
    Inventors: Dallas H. Burnett, C. Hugh Burnett, Wade L. Burnett, Tom M. Burnett
  • Patent number: 8936720
    Abstract: The present system and method in one embodiment limit a maximum instantaneous peritoneal volume to a comfortable level, while allowing the dialysis machine to advance to fill a prescribed volume whenever the drain ends after a minimum drain percentage has been attained. If a low drain condition occurs, the nominal fill volume is lowered and a therapy cycle is added, so that a prescribed total amount of fresh therapy fluid is used during therapy, maximizing therapeutic benefit. An allowable residual volume at the end of an incomplete drain is increased, thereby lowering the probability of a subsequent low drain condition.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: January 20, 2015
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Robert W. Childers, Ying-Cheng Lo, Peter Hopping
  • Patent number: 8900458
    Abstract: A separation apparatus using a membrane for diafiltration, which provides precise fractionation of a target substance by monitoring and regulating permeability of the target substance based on measurement values and analytical values indicating separation status, such as physical values and concentration of a permeate liquid, a circulating liquid and an internal circulating liquid in a membrane device. A diafiltration process including adding a cleaning liquid to an treating liquid which contains multiple target substances and extracting a target substance into the permeate liquid supplied from a membrane separation apparatus to fractionate the target substance from other target substances remaining in a residual liquid.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: December 2, 2014
    Assignee: Tsukishima Kankyo Engineering Ltd.
    Inventor: Yasuhiro Tateishi
  • Patent number: 8852433
    Abstract: Device (5) for filtering blood including a filter unit (7) having a blood filter, an inlet (8) for blood to be filtered and being connectable to an artery of a patient and a blood outlet (9) for filtered blood and being connectable to a vein of the patient, and having a filtrate container (6,14), that encloses the filter unit (7), for receiving filtrate (12) passing through the blood filter during a filtering process and that the filtrate container (6,14) is a closed container, which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted. The invention also concerns a system including the above device.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: October 7, 2014
    Assignee: Gambro Lundia AB
    Inventor: Anders Nilsson
  • Patent number: 8834712
    Abstract: According to one embodiment, a seawater desalination system includes a membrane filtering pump, a first to third flowmeter, a filtering membrane, a high-pressure pump, a pressure gauge, a reverse osmosis membrane, a discharge valve and a control module. The membrane filtering pump outputs seawater according to a first control signal. The first flowmeter measures flow rate Q1. The high-pressure pump outputs filtered water from the filtering membrane according to a second control signal. The first pressure gauge measures pressure P1. The reverse osmosis membrane desalinates the filtered water into fresh water. The second flowmeter measures flow rate Q2. The third flowmeter measures flow rate Q3. The discharge valve discharges a high-concentration salt water according to a third control signal. The control module performs first, second, and third flow rate control with reference to the flow rate Q1, Q2 and Q3 and the pressure P1.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: September 16, 2014
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Kyosuke Katayama, Takeshi Matsushiro, Futoshi Kurokawa, Takanori Fukagawa, Kazuhiko Kimijima, Koichi Matsui
  • Patent number: 8808539
    Abstract: The invention provides a method and apparatus for continuous monitoring of permeate from membrane elements in a water treatment plant, including a desalination plant. The apparatus includes a probe that includes multiple sensors such that at least one sensor is associated with each membrane element. Each sensor is coupled to a node, which is configured to communicate a signal associated with the permeate quality to a central node sink. The node may communicate wirelessly with the node sink.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: August 19, 2014
    Assignee: Saudi Arabian Oil Company
    Inventors: Anastasios J. Karabelas, Ioannis Gragopoulos, Nicos P. Isaias
  • Patent number: 8784668
    Abstract: In a regenerative dialysis system, in a method for controlling a regenerative dialysis system, and in a controller for a regenerative dialysis system, an embodiment of the system comprises an input pump that pumps fresh dialysate fluid into a dialyzer at an input rate. An output pump pumps used dialysate fluid from the dialyzer at an output rate. An ultrafiltration rate of the system is related to the output rate relative to the input rate. A sorbent cartridge filters the used dialysate fluid to generate the fresh dialysate fluid. A controller controls the ultrafiltration rate of the system in response to a flow rate of the dialysate fluid through the sorbent cartridge.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: July 22, 2014
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventor: Michael J Beiriger
  • Publication number: 20140197105
    Abstract: A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane.
    Type: Application
    Filed: January 11, 2013
    Publication date: July 17, 2014
    Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventor: THE CHARLES STARK DRAPER LABORATORY, INC.
  • Patent number: 8771508
    Abstract: A dialyzer mount arranged to support a plurality of differently sized and/or shaped dialyzer units and to accommodate different distances between dialysate connections on the dialyzer units. The dialyzer mount, which may be located on a front panel of the dialysis unit, may include a pair of flange portions that are each arranged to engage with a respective dialysate quick-connect fitting connected to a dialysate port of the dialyzer. Each flange portion may be arranged to engage with a groove on the quick connect fitting that is located between a portion of the base of the quick connect fitting and a slide element of the quick connect fitting. One flange portion may include an adjustable support that is moveable, e.g., in a vertical direction.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: July 8, 2014
    Assignee: DEKA Products Limited Partnership
    Inventors: Kevin L. Grant, Jason A. Demers, James D. Dale, Arun D. Chawan, David E. Collins
  • Patent number: 8764987
    Abstract: An apparatus and a method for the determination and regulation of the concentration of at least one dissolved substance in a fluid circuit, in which the fluid circuit includes at least two partial circuits separated by a filter in a semi-permeable manner, includes a detection unit for determining a concentration difference of at least one first dissolved substance, a determination unit for determining the influence of at least one second dissolved substance which is not identical to the at least one first dissolved substance, and a regulation unit for regulating the concentration of the at least one dissolved substance in the fluid circuit.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: July 1, 2014
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Malte Gross, Andreas Maierhofer
  • Patent number: 8691086
    Abstract: A reverse osmosis system and method of operating the same includes a first pump receiving feed fluid at a first pressure and increasingly pressurizing the feed fluid to a second pressure higher than the first pressure. A membrane housing having an inlet, a membrane, a permeate outlet and a brine outlet. The inlet receiving feed fluid. A hydraulic energy management integration system (HEMI) having a turbine portion, a pump portion and a motor. The brine outlet fluid is in fluid communication with the turbine portion. The reverse osmosis system also includes a second pump and a controller controlling the motor to retard rotation of the HEMI while the first pump increasingly pressurizes the feed fluid to the second pressure.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: April 8, 2014
    Assignee: Fluid Equipment Development Company, LLC
    Inventor: Eli Oklejas, Jr.
  • Publication number: 20140091018
    Abstract: Device (5) for filtering blood including a filter unit (7) having a blood filter, an inlet (8) for blood to be filtered and being connectable to an artery of a patient and a blood outlet (9) for filtered blood and being connectable to a vein of the patient, and having a filtrate container (6,14), that encloses the filter unit (7), for receiving filtrate (12) passing through the blood filter during a filtering process and that the filtrate container (6,14) is a closed container, which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted. The invention also concerns a system including the above device.
    Type: Application
    Filed: December 4, 2013
    Publication date: April 3, 2014
    Applicant: GAMBRO LUNDIA AB
    Inventor: Anders Nilsson
  • Patent number: 8617392
    Abstract: Device (5) for filtering blood including a filter unit (7) having a blood filter, an inlet (8) for blood to be filtered and being connectable to an artery of a patient and a blood outlet (9) for filtered blood and being connectable to a vein of the patient, and having a filtrate container (6,14), that encloses the filter unit (7), for receiving filtrate (12) passing through the blood filter during a filtering process and that the filtrate container (6,14) is a closed container, which in a filled state is arranged to establish a counter-pressure over the blood filter, whereby the filtering process is interrupted. The invention also concerns a system including the above device.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: December 31, 2013
    Assignee: Gambro Lundia AB
    Inventor: Anders Nilsson
  • Patent number: 8597516
    Abstract: The present invention relates to a method and system for using a very large pore hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: December 3, 2013
    Assignee: Immunocept, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Patent number: 8584535
    Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: November 19, 2013
    Assignee: Innova Prep LLC
    Inventors: Andrew Edward Page, Zachary A. Packingham, David Scott Alburty, Alec D. Adolphson
  • Patent number: 8580110
    Abstract: A proposed blood treatment apparatus includes: a blood treatment unit, a pair of fluid pumps and a pair blood pumps. The blood treatment unit is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit. The blood pumps are configured to extract untreated blood from a blood source, pass extracted blood through the blood treatment unit and deliver treated blood to a target vessel. Additionally, the fluid pumps are configured to control the operation of the blood pumps via the blood treatment fluid. Moreover, a flow control device is configured to control a trans-membrane flow between the blood side and the a fluid side of the blood treatment unit. Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: November 12, 2013
    Assignee: Gambro Lundia AB
    Inventors: Lennart Jönsson, Olof Jansson, Mattias Holmer, Jan Sternby, Anders Nilsson, Per Hansson
  • Patent number: 8568595
    Abstract: A method for determining or predicting the adequacy parameters that will be achieved at the end of a kidney substitution treatment during said kidney substitution treatment wherein the kidney substitution treatment is provided by a machine, which has an extracorporeal blood system pumping the patient blood through the blood chamber of a dialyzer, wherein the dialyzing fluid collects the waste products from the patient after flowing through the dialyzing fluid chamber of the dialyzer and wherein a device able to measure a adequacy parameter is coupled with the kidney substitution treatment machine and wherein the slope of a preferable linear guideline for the adequacy parameter is compared to the slope of the delivered adequacy parameter and if the slope of both are equal a linearization is performed to determine or predict the adequacy parameter at the end of the kidney substitution treatment.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: October 29, 2013
    Assignee: B. Braun Avitum AG
    Inventor: Alex Castellarnau
  • Patent number: 8557116
    Abstract: The present invention discloses a method and apparatus for separating particles and dissolved matter from a fluid stream. Specifically, the present invention includes a first pressure source which transports untreated fluid into a separator annulus with a filter element disposed therein. The untreated fluid is placed under appropriate pressure sufficient to produce turbulent flow, increased particle kinetics and/or cavitation physics allowing the desired fluid to penetrate and pass into and through the filter media. The filtered fluid is then transported to a collection tank. The contaminant particulate matter retained by the filter media may be removed by the instantaneous reverse pressurization of the separator annulus by a second pressure source thereby removing the contaminant particles away from contact with the filter media, and which may then be transported to a waste collection tank or a concentrator for further treatment.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: October 15, 2013
    Assignee: Tervita, LLC
    Inventors: Raymond Ford Johnson, Markley Dean Johnson, Rodney Grage
  • Patent number: 8551342
    Abstract: The present invention proposes a method of operating a blood treatment apparatus for the extracorporeal blood treatment of a patient, a blood volume monitor for monitoring an extracorporeal blood treatment of the patient by means of a blood treatment apparatus, and a blood treatment apparatus.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: October 8, 2013
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Ulrich Moissl, Paul Chamney, Peter Wabel
  • Publication number: 20130240443
    Abstract: The present invention relates to methods for dosing a substituate produced by a blood treatment apparatus. Dosing for the present invention is via a hydraulic system of the blood treatment apparatus, the hydraulic system having at least one dialysis liquid supply line which leads into a dialyzer and at least one substituate line. Regulating or controlling the size of the share which passes through the second filtration stage is performed by affecting at least one conveying apparatus and/or at least one flow limitation device and/or a flow divider valve, which are each located or which each operate in the dialysis liquid supply line and/or the substituate line and/or in the branch line which connects the dialysis liquid supply line with the substituate line. The present invention further relates to a control device, a blood treatment apparatus, a medical functional apparatus, and a computer-readable storage medium related to the methods.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 19, 2013
    Applicant: Fresenius Medical Care Deutschland GmbH
    Inventors: Soeren Gronau, Juergen Haecker, Ralf Mueller
  • Patent number: 8529761
    Abstract: A reverse osmosis system includes a plurality of feed pumps each having a feed pump input and a feed pump output, an input manifold in fluid communication with the feed pump inputs and a membrane feed manifold in fluid communication with the feed pump output. The system also includes a plurality of membrane chambers each in fluid communication with the membrane feed manifold and generating a permeate output and a brine output, each brine output in fluid communication with a brine manifold. The system further includes a plurality of booster devices each having a turbine portion with a turbine input in fluid communication with the brine manifold and a pump portion having a booster device pump input and a booster device pump output, each booster device pump output in fluid communication with the membrane feed manifold. The system includes a pump input manifold in fluid communication with the booster device pump input.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: September 10, 2013
    Assignee: Fluid Equipment Development Company, LLC
    Inventor: Eli Oklejas, Jr.
  • Patent number: 8518262
    Abstract: A method of integrating individual water treatment assemblies into a seamless water treatment control system. A Reverse Osmosis assembly contains a controller wherein all other pretreatment and post-treatment assemblies are electrical coupled thereto. The controller is preprogrammed for use in recognizing the coupling of the pretreatment and/or post treatment assemblies wherein and for receiving all control commands for operation thereof. The controller employs cells that allows and installer to interconnect assemblies by coupling low voltage control signal wiring having predefined inputs, set up as PnP, or by use of a personal wireless network.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: August 27, 2013
    Assignee: Nalco Company
    Inventors: Scott Watkins, Raymond Perdue
  • Patent number: 8512554
    Abstract: In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: August 20, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Anping Yu, Robert W. Childers, Borut Cizman
  • Patent number: 8333891
    Abstract: A field flow fractionator to separate particles contained within an injected sample aliquot is described. As required, said fractionator may be used to capture, for subsequent removal, specific predefined classes of such particles. Based upon the cross flow or asymmetric flow field flow fractionators, the fractionator disclosed contains means to vary the applied transverse flows at a plurality of locations along the length of its separating channel. One embodiment utilizes a plurality of separated compartments, each lying below a distinct and corresponding membrane supporting permeable frit segment, are provided individual means to control the localized flow through the membrane section thereabove. A corresponding concentric compartment implementation achieves the same type of compartmentalized cross flow when integrated with a hollow fiber fractionator.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: December 18, 2012
    Assignee: Wyatt Technology Corporation
    Inventor: Philip J. Wyatt
  • Publication number: 20120298581
    Abstract: A device (25) and a method for detecting the cause of a deviation from an ideal operating state of an extracorporeal blood treatment, wherein blood to be treated in an extracorporeal blood circulation (9) flows through the blood chamber (3) of a dialyzer (1), subdivided by a semipermeable membrane (2) into a blood chamber (3) and a dialysis fluid chamber (4), and dialysis fluid flows through the dialysis fluid chamber (4). The method includes the following: changing a characteristic (170; 171) of the dialysis fluid upstream from the dialysis fluid chamber (1), measuring a characteristic of the dialysis fluid downstream from the dialysis fluid chamber, determining a dialysance or clearance at a certain point in time during the blood treatment, detecting a deviation in the dialysance or clearance, and detecting the cause of a deviation from an ideal operating state as a function of the certain point in time.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 29, 2012
    Applicant: Fresenius Medical Care Deutschland GmbH
    Inventors: Wolfgang Wehmeyer, Andreas Wuepper
  • Patent number: 8303807
    Abstract: The invention relates to a dialyser having a blood-pressure measuring unit assigned to the dialyser, a pulse-wave-transit-time measuring system assigned to the dialyser and an evaluation unit, the evaluation unit being configured such that a signal representing the blood pressure can be derived from this pulse wave transit time; the parameters describing the relationship between the pulse wave transit time and the blood pressure can be determined from a plurality of measurements made by the blood-pressure measuring unit and simultaneous measurements made by the pulse-wave-transit-time measuring system, it being possible to determine at least two of these pairs of measured values at times when the absolute and/or the relative pulse-wave-transit-time deviation is above a threshold value.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: November 6, 2012
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Wei Zhang
  • Publication number: 20120275955
    Abstract: In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.
    Type: Application
    Filed: April 26, 2012
    Publication date: November 1, 2012
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Howard Bernstein, Kristin Horton
  • Patent number: 8298427
    Abstract: A method for controlling an apparatus for treating blood outside the human body, with a view to improving the operation of the apparatus, the apparatus including a semi-permeable membrane carrying out an exchange of solutes, referred to as dialysis, and of liquid, referred to as ultrafiltration, with the blood, the method including at least one iteration of the following steps: determination of a so-called instantaneous value, of an ultrafiltration coefficient corresponding to the ratio of an ultrafiltration flow rate to a difference in pressure, the so-called transmembrane pressure, on either side of the semi-permeable membrane, comparison of the instantaneous value with at least one previously determined characteristic value; and control of the treatment apparatus to reach a maximum value of the ultrafiltration coefficient, the control including a variation of the ultrafiltration flow rate up to a value corresponding to the maximum value of the ultrafiltration coefficient.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: October 30, 2012
    Assignee: RD Nephrologie
    Inventors: Alain Ficheux, Angel Argiles Ciscart
  • Patent number: 8257582
    Abstract: In an embodiment, an automated peritoneal dialysis (“APD”) machine includes at least one pump, a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient, and an input device operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the APD machine.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: September 4, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Anping Yu, Robert W. Childers, Borut Cizman
  • Patent number: 8257594
    Abstract: A water-on-water filtration system that includes a filter member and two storage vessels. The system includes a plurality of valves that are controlled to place a first of the storage vessels in a fill state in which the first storage vessel is being filled with filtered water, and concurrently place the second of the storage vessels in a service state in which filtered water held in the second storage vessel is delivered as an output of the filtration system. The filtration system can be configured to supply a constant output of filtered water to meet a constant demand while using a relatively small filter member and relatively small storage vessels.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: September 4, 2012
    Assignee: 3M Innovative Properties Company
    Inventors: Robert E. Astle, Martin J. Blaze, Katrina Prutzman
  • Patent number: 8231787
    Abstract: A system, method and device are disclosed for bio-processing a feed stream providing a constant output by operating a continuous single-pass tangential-flow process. Embodiments are operated without large circulation pumps. Other embodiments use components which can be disposed after a single use. The system, method and device can also be used to provide constant output diafiltration.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: July 31, 2012
    Assignee: SPF Innovations, LLC
    Inventors: Leon Mir, Gaston de los Reyes
  • Patent number: 8221617
    Abstract: An apparatus for reclaiming hot process water from a animal processing facility includes a screen portion, a filtration portion and optionally a UV sterilization portion. The screen portion receives dirty hot process water and removes macroscopic debris to produce raw tank water. Raw tank water is pumped through the filtration portion at relatively high pressure in order to remove substantially all solids to produce a permeate side stream. The permeate is optionally passed through a very intense ultra-violet field in order to produce uncontaminated reclaimed hot process water which may be safely reintroduced as hot scald water for the poultry cleaning process.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: July 17, 2012
    Assignee: American Water Purification, Inc.
    Inventors: Danny E. Gates, James E. Loewen, Aron T. Wilde
  • Patent number: 8216478
    Abstract: An apparatus and a method for monitoring the supply of replacement fluid during an extracorporeal treatment of blood is disclosed. Detection of the supply of replacement fluid upstream or downstream of the dialyser or filter is based on a measurement of the optical or physical density of the blood or of a constituent of blood in the extracorporeal circulation. To detect pre- or post-dilution, the blood flow rate and/or the replacement rate and/or the flow rate of the fluid removed from the blood through the dialyser membrane is altered, and the density of the blood or of the constituent of blood is measured upstream and/or downstream of the dialyser. Additionally, an apparatus for treating blood with an apparatus for monitoring the supply of replacement fluid is disclosed.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: July 10, 2012
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Joachim Noack, Joerg Dreyhsig