Abstract: An improved cross-flow filtration unit utilizing at least one two-ply membrane is disclosed that has a particular pore size relationship in the two membrane layers.

Abstract: A structure including a support defining an opening, and a tensilely stressed thin-film membrane disposed to occlude the opening, the membrane contacting at least a portion of the support. The stressed membrane includes a material having a characteristic crack spacing greater than one-half of a minimum dimension of the membrane and less than ten times the minimum dimension. A structure including a support defining a opening having a minimum opening dimension, and a compressively stressed thin-film membrane disposed to occlude the opening, the membrane contacting at least a portion of the support. The stressed membrane includes a membrane material having a critical aspect ratio for buckling that is greater than a ratio of one-half of the minimum opening dimension to a thickness of the membrane, and the critical aspect ratio for buckling is less than a ratio of ten times the minimum opening dimension to the thickness of the membrane.

Abstract: A new design for a static diffusion cell for use in a diffusion sampling apparatus to be used in conjunction with automated or manual sampling is disclosed. The diffusion cell of present invention provides to an improved and efficient diffusion assay system.

Abstract: In order to provide a spacer for filter modules which may be used not only for plate and frame filter modules, but also for spiral wound-type filter modules and which allows high packing densities while providing optimized cleanability, a spacer for filter modules is proposed to be disposed between two layers of a filter medium, said spacer comprising an essentially flat structured sheet material having upper and lower projections on the upper and lower surfaces thereof, respectively, said upper and lower projections defining an upper and lower bearing face for the layers of filter medium, wherein said projections rise from said upper and lower surfaces with wall portions and terminate in top portions, said upper and lower projections being spaced from each other in a direction parallel to the surface of the sheet material.

Abstract: A filtration apparatus is provided wherein a filtration membrane is positioned by gaskets on feed plates and filtrate plates rather than being bonded thereto.

Abstract: A filtration cartridge is provided comprising one or a stack of filtration units sealed to each other at their inner periphery and their outer periphery and to end caps thereby eliminating the need for a housing surrounding the stack. Fluid pathways are provided so that filtration of all incoming feed is assured prior to passing from the cartridge as filtrate.

Abstract: A bioreactor and methods of using same for making tissue constructs and for conditioning tissue-engineered constructs and harvested tissues such as cryopreserved tissues. The bioreactor allows for static and dynamic culture/conditioning. The bioreactor is dual chambered (one chamber above and one below the cells or construct) to allow for application of biochemical and/or biomechanical stimuli to each side of the cells/construct.

Abstract: The present invention relates to a spacer for membrane modules comprising at least one inserted element and support members, the support members being spaced apart by the at least one inserted element forming flow channels between the support members and the inserted element for guiding permeates to the at least one permeate collection device, which at least one permeate collection device being in perpendicular contact with the flow channels, or guiding concentrate through flow channel out of the membrane module. The invention relates further to a membrane module comprising the permeate spacer, uses of the membrane module and a spiral wound membrane comprising the permeate spacer.

Abstract: Membrane holder for membrane adsorber chromatography comprising a housing body (12) with a reception space for at least one layer of adsorber membranes (22) and at least one first housing cap (34) for closing a first reception space opening, which can be fixed to the housing body (12), a liquid stream being introducible via first liquid guide means (36) through the first housing cap (34) and the first reception opening into the reception opening, so that it passes through the adsorber membranes (22) and flows away through a second reception space opening. The first housing cap (34) can be screwed as a first union nut onto the housing body (12) and a first brace element (24), which can be clamped between the first cap (34) and the housing body (12) via a flange (32) extending beyond the first reception space opening, can be fixed leaktightly in a basket-like insert (14) with a liquid-tight wall and a perforated bottom (18), which is used to receive the adsorber membranes (22).

Abstract: Various MEMS filter elements or modules are disclosed, and which may be used in a glaucoma implant (490). One such MEMS filter module (34) includes a first film (70) and a second film (46) that are spaced and interconnected by a plurality of supports (78). A plurality of first flow ports (74) extend through the first film (70), and a plurality of second flow ports (50) extend through the second film (46). A plurality of annular filter walls (54) extend from the second film (46) toward the first film (70), and are separated therefrom by a filter trap gap (58).

Abstract: This concerns a device whose filtering membrane (4) is gripped annularly at the periphery between an annular transverse wall (32) forming part of a drainage body and an axially oriented cylindrical wall (9) of an intake body, which lateral wall has an elastomer seal (13) which forms the edge thereof and by means of which this wall comes into contact with the membrane (4), this device being provided with a second seal (55) which has an arched profile, the external annular end (61) of which bears against said annular transverse wall (32) radially beyond said membrane (4), and the internal end (57) of which is connected to said seal (13) on the lateral wall (9) of said reservoir (5), hereinafter referred to as the first seal.

Abstract: An aeration system for a submerged membrane module has a set of aerators connected to an air blower, valves and a controller adapted to alternately provide a higher rate or air flow and a lower rate of air flow in repeated cycles. In an embodiment, the air blower, valves and controller, simultaneously provide the alternating air flow to two or more sets of aerators such that the total air flow is constant, allowing the blower to be operated at a constant speed. In another embodiment, the repeated cycles are of short duration. Transient flow conditions result in the tank water which helps avoid dead spaces and assists in agitating the membranes.

Abstract: Methods of separating fluids using capillary forces and/or improved conditions for are disclosed. The improved methods may include control of the ratio of gas and liquid Reynolds numbers relative to the Suratman number. Also disclosed are wick-containing, laminated devices that are capable of separating fluids.

Abstract: This invention relates to a polymeric membrane composition comprising an associating polymer. The polymer coating is characterized as having hard and soft segments where the hard segment comprises TMPA, combined with HDPA. The membrane may utilize a porous substrate.

Abstract: A liquid filter cartridge system includes a housing, a valve body, a valve actuator, a filter, an inlet passage having a portion extending through each of the valve body and the valve actuator and into the filter, and an outlet passage having a portion leading out of the filter, and extending through each of the valve actuator and the valve body. An interface is located between the inlet passage portions in the valve actuator and the filter and an interface is located between the outlet passage portions in the valve actuator and the filter. The inlet passage interface and the outlet passage interface may lie in the same plane as each other. They may each comprise a face seal comprising an axial seal between the valve actuator and the filter. They may each comprise a seal between the valve actuator and the filter, wherein the two seals are sealed via compression and not via sliding contact.

Abstract: A method for separating aromatic hydrocarbons from a feed stream. The method includes flowing the feed stream through a first channel within a first wafer assembly that may contain an underflow distribution weir. Next, the feed stream is exposed to a first thin film polymer membrane. A stream permeates through the first thin film polymer membrane, and the permeate is produced from the first wafer assembly. The retentate is directed via a redistribution channel (such as a tube) to a second wafer assembly that may contain an underflow distribution weir. This retentate is exposed to a second thin film polymer membrane. A second permeate stream is created that permeates through the second thin film polymer membrane. The second permeate stream is conducted into the permeate zone and ultimately produced from the second wafer assembly. An apparatus for separating aromatic components from a feed stream is also disclosed. In the preferred embodiment, the apparatus includes a series of tandem wafer assemblies.

Abstract: This invention relates generally to filtration cassettes, and, more particularly to methods of fabricating cross-flow filtration cassettes. Cassettes of the invention are characterized, in part, by a series of sealing channels which selectively seal the filtrate and retentate ports to prevent undesired flow. The sealing channels have formed barriers on either side thereof which create side-walls for precisely controlling the flow of the sealant during the cassette formation. Filtration cassettes of the present invention can be manufactured from conventional membrane and flow screen components and can utilize both injection molding and vacuum assisted resin transfer molding fabrication processes.

Abstract: A filtration system is provided with filter media operable to remove solids, particulate and colloidal matter from a process fluid. Acoustic, vibration and sonic energy may be used to clean associated filter media to allow substantially continuous filtration of process fluids. The filtration system may be satisfactorily used with process fluids having a relatively high concentrations of solids, particulate and colloidal matter.

Abstract: A feeding tray for retaining a liquid nutrient liquid is provided for use with a multiwell filter plate. The feeding tray includes a flat support surface surrounded by walls which retain liquid on the support surface. The flat support surface includes protrusions positioned to contact the membrane portion of a multiplicity of wells of the multiwell filter plate when the multiwell filter plate is removed from the feeding tray. These protrusions remove residual liquids from the bottom of each filter well thereby minimizing cross contamination in subsequent processing steps. Additionally, it may contain one or more baffles, in lieu of or in addition to the protrusions for controlling liquid movement during handling.

Abstract: A fluid path control element which when stacked alternatively with a fluid porous sheet can be formed into a filtration module. The fluid path control element comprises a porous membrane having sealed to a portion of its periphery a thermoplastic element that extends into an opening either through the membrane or in an opening through the thermoplastic element. The portion of the thermoplastic element that extends into the opening can be heat sealed with a second thermoplastic element to prevent fluid flow between the opening and the membrane.

Abstract: To reuse support plate and to fix a membrane sheet by the same method both in a new product manufacturing and in regeneration. In a flat membrane element 10 including a deposit fixed portion 18 formed by lapping a membrane sheet 14 performing solid-liquid separation onto a support plate 12 supporting the membrane sheet 14 and by emitting a laser to a circumferential edge of the membrane sheet 14 to deposit fix the member sheet 14 onto the support plate 12, and making an inside of the membrane sheet 14 surrounded by the deposit fixed portion 18 be a solid-liquid separating area 20; an embrocation 22 having laser absorption property is applied on the surface of the membrane sheet 14 of the deposit fixed portion 18. At the time of regeneration, such a portion of the membrane sheet 14 that corresponds to the solid-liquid separating area 20 is cut off and, after that, a new membrane sheet is lapped on the embrocation 22 and the new membrane sheet and the embrocation 22 are deposit fixed by a laser.

Abstract: Even when a membrane sheet contains an inorganic material, the membrane sheet and a support plate are properly deposited by a laser emission. In a manufacturing method of a flat membrane element lapping a membrane sheet 10 performing solid-liquid separation on a support plate 20 supporting the membrane sheet 10 and emitting a laser 24 to a mutual joint portion to deposit the membrane sheet 10 and the support plate 20, when the membrane sheet 10 contains an inorganic material, the support plate 20 is formed by a material having laser penetration and the laser 24 is emitted from the support plate 20 side to the joint portion.

Abstract: Various MEMS filter elements or modules are disclosed. One such MEMS filter module (34) includes a first film (70) and a second film (46) that are spaced and interconnected by a plurality of supports (78). A plurality of first flow ports (74) extend through the first film (70), and a plurality of second flow ports (50) extend through the second film (46). A plurality of annular filter walls (54) extend from the second film (46) toward the first film (70), and are separated therefrom by a filter trap gap (58). A filter trap chamber (62) is disposed on each side of each filter trap gap (58). Therefore, fluid will flow into one filter trap chamber (62), through a filter trap gap (58), and into another filter trap chamber (62), whether the flow is introduced into the filter module (34) through the first flow ports (74) or the second flow ports (50).

Abstract: An apparatus containing crosslinked polymer for binding phosphate anions is provided, the polymer comprises a polyvalent cation attached to the polymer through at least one covalently bound anionic functional group, and wherein the anionic group is selected from a group consisting of sulfonate, carboxylate, phosphonate and mixtures thereof and wherein the cation is selected from a group consisting of aluminum, calcium, magnesium, molybdenum, manganese, titanium, barium, strontium, zirconium, vanadium, scandium, lanthanum, yttrium, cerium, nickel, iron, copper, cobalt, chromium, zinc and mixtures thereof.

Abstract: An anti-microbial filter (105) for a micro-fluidic system (100) includes a silicon-based filter membrane (213) having holes (218) formed therein. The membrane (213) is formed on a substrate (211). One side of the filter membrane (213) has an anti-microbial coating (216) between the holes (218) on the filter membrane (213) and the other side can include filter supports formed from a silicon substrate. A method for making the anti-microbial filter (105) includes forming a filter membrane (213) on a substrate (211), forming holes (218) in the membrane (213) by providing a filter mask (215) and etching holes (218) through holes (222) in the mask (215). Then portions of the substrate (211) are removed from the filter membrane (213) using a masking and etching process to expose the holes (218). An anti-microbial coating is applied to the membrane (213) adjacent the holes (218).

Abstract: An aeration system for a submerged membrane module has a set of aerators connected to an air blower, valves and a controller adapted to alternately provide a higher rate or air flow and a lower rate of air flow in repeated cycles. In an embodiment, the air blower, valves and controller, simultaneously provide the alternating air flow to two or more sets of aerators such that the total air flow is constant, allowing the blower to be operated at a constant speed. In another embodiment, the repeated cycles are of short duration. Transient flow conditions result in the tank water which helps avoid dead spaces and assists in agitating the membranes.

Abstract: A nanofeature particulate trap comprising a plurality of densely packed nanofeatures, such as nanotubes, and a particulate detector incorporating the nanofeature particulate trap are provided. A method of producing a nanotrap structure alone or integrated with a particulate detector is also provided.

Abstract: An internal filter includes a lower substrate and an upper substrate. Fluid passages are formed by etching grooves into the surfaces(s) of the upper and/or lower substrates and/or in one or more intermediate layers. The filter pores extending between the fluid passages are formed by etching second grooves that fluidly connect the fluid passages. Two or more sets of the one or two intermediate layers can be implemented to provide additional filter passages and/or pores. Each set can be connected to a separate fluid source and/or a separate microfluidic device. In another internal filter, the inlet and outlet passages and the filter pores are formed on the same upper or lower substrate. The inlet and outlet passages are partially formed in a first step. In a second step, the inlet and outlet passages are completed at the same time that the filter pores are formed.

Abstract: An apparatus for purifying water, that includes a frame, in connection with which is arranged a primary space for water to be filtered, secondary space for filtered water and a filter. The filter is arranged to filter water, that is driven by gravity from the primary space existing in the frame to the secondary space, wherein the filtering influence of the filter is based essentially on a thin filtering film made of plastic based material. Essentially underneath the primary space is arranged an accessory space for the filtering means, that is in connection with the primary space and that has an essentially smaller cross-section than the same, in order to keep the filter surrounded by unclean water in the auxiliary space of the primary space, being limited from the secondary space, totally separate from the secondary space.

Abstract: A feeding tray for retaining a nutrient medium is provided for use with a multiwell filter plate. The feeding tray includes an inclined support surface surrounded by walls that retain nutrient medium on the support surface. The support surface is inclined away from an area for introducing nutrient medium into the feeding tray toward an area for draining the feeding tray of nutrient medium.

Abstract: A separation device, such as a filter or separation line apparatus, and method of making the same.

Abstract: In a filtration device (1) comprising a pressure-resistant housing (2) with a liquid inlet opening (3) and an outlet opening (4) for filtered matter, into which a collecting channel (12) terminates, at least one filter element (8–11) designed as flat membrane is connected to the collecting channel (12) in a pressure-tight manner. This device provides a high liquid throughput at the same time having a compact construction.

Abstract: The present invention relates to the field of synthetic polymeric microfiltration membrane materials that are fabricated to separate liquids from solids contained therein. One aspect of the invention relates to a highly asymmetric, hydrophilic microfiltration membrane with high surface porosity. The membrane is rendered hydrophilic through co-casting the sulfone polymer with a hydrophilic polymer, such as polyvinylpyrrolidone. The membranes of the invention are highly useful in testing devices for the quick detection of properties or components contained in liquid samples, such as diagnostic applications, as well as for other filtration applications that demand relatively large pore sizes, thick membranes, high asymmetry, and/or high lateral wicking speeds.

Abstract: Advanced submerged membrane systems are provided. Said submerged membrane systems have multiple membrane modules comprising of strips of flat sheet membrane, bundles of self-support hollow fiber membranes braided together for reinforcement, tubular membranes, and braid supported hollow fiber membranes. Said submerged membrane systems have alternating relay, or two-way floating switch or computer to control filtration and back flush/pulse cleaning. Said submerged membrane systems have an oscillating motor, and aerator which can generate liquid vortex (whirlpool) flow around membrane to keep membrane from fouling. The present invention provides advanced submerge membrane systems at very low cost for drinking water production, wastewater treatment and membrane bioreactors for biotech, pharmaceutical and other industries.

Abstract: A liquid-liquid extraction system including an outer chamber and an inner chamber. The outer chamber is adapted to contain one of a feed solution and a liquid extractant and defines a containment region. The inner chamber is adapted to contain the other of the feed solution and the liquid extractant within a lower portion of the inner chamber. The inner chamber is defined by a microporous membrane sleeve that internally maintains a frame. Upon final assembly, at least the lower portion of the inner chamber is positioned within the containment region of the outer chamber such that the microporous membrane sleeve establishes an extraction interface between contents of the inner and outer chambers. In one embodiment, the flow region of the microporous membrane sleeve is immersed within a feed solution otherwise contained within the outer chamber.

Abstract: This invention relates generally to filtration cassettes, and, more particularly to methods of fabricating cross-flow filtration cassettes. Cassettes of the invention are characterized, in part, by an internal porting (e.g., manifolding) feature which eliminates the need for a separate step to seal individual components prior to assembly of the filtration cassette. Filtration cassettes of the present invention can be manufactured from conventional membrane and flow screen components and can utilize both injection molding and vacuum assisted resin transfer molding fabrication processes.

Abstract: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.

Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

Abstract: This invention provides a continuous blood filtration apparatus capable of filtering a plurality of blood samples continuous by using blood filter units to prepare plasma or serum samples in a short period, which comprises, a conveyor conveying a plurality of blood reservoirs each of which contains a blood sample and in which a suction nozzle of a blood filter unit has been put, a manifold connected to a suction line, couples of a valve and a connector for connecting the manifold to the blood filter unit provided on the end of each branch of the manifold, and a mechanism of moving the blood reservoirs in vertical direction.

Abstract: Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds interact with at least one remotely controlled pinch valve which engages only the outside surface of the manifold tubing. Such manifold and pinch valve systems can be used in conjunction with a peristaltic type of pump, which, together with the remotely operated pinch valve, can be operated by a controller which provides automated and accurate delivery of biotechnology fluid in an aseptic environment while avoiding or reducing cleaning and quality assurance procedures.

Abstract: The present invention includes a membrane construction for selectively transferring a constituent to or from a fluid. The membrane construction includes a multi-layer fluid impermeable support sheet having a plurality of supports on at least one side of the support sheet that form a plurality of flow channels. At least one layer of the multi-layer support sheet is a bonding layer. A fluid permeable layer extends over the flow channels and is bonded to the plurality of the supports by the bonding layer.

Abstract: An improved wide passage cross-flow filtration cassette is disclosed that incorporates an open mesh matrix retentate spacer that is dimensioned and oriented so as to improve flux and cause turbulence in the flow of fluids through the cassette.

Abstract: The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.

Abstract: The invention relates to a composite membrane (1) consisting of a flat support body (2) comprising relative big through flow holes (3) and on which at least one separating layer is applied as a membrane layer (4) having a given number of pores and pore sizes. In order to regulate the temperature of the support body, said support body (2) is connected to a device (5) that can be regulated by a regulating device (S) with the purpose of supplying a predetermined energy to the support body (2) and/or diverting energy from the support body (2). The membrane layer (4) is applied on the support body (2) in a heat-conductive manner so that any change in the temperature of the support body provokes a change in the temperature of the membrane layer.

Abstract: There is disclosed a device for the simultaneous separation of particles and target substances from liquid feeds by adsorption membranes having particle-passing apertures therein.

Abstract: Cross-flow filters having improved uniformity in transmembrane pressures and consequent much greater flux are provided by the installation of barriers in permeate channels.

Abstract: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system.

Abstract: A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same.

Abstract: Methods of separating fluids using capillary forces and/or improved conditions for are disclosed. The improved methods may include control of the ratio of gas and liquid Reynolds numbers relative to the Suratman number. Also disclosed are wick-containing, laminated devices that are capable of separating fluids.

Abstract: Elongated processing elements are anchored at opposite ends thereof between holding discs retained within rigid seal rings enclosing a chamber within a cylindrical module housing, through which a flow of contaminate-laden bilgewater is conducted. Such discs are formed within the seal rings with the elongated elements positioned therein by deposit and curing of epoxy resin. Such elements are then assembled within the module housing to seal the chamber thereby established therein. Spacing between the bundled elements is maintained by spacers to accommodate filtration of the bilgewater during flow thereof through the chamber and lateral outflow of a cleansed filtered portion from the elements through a drain outlet.