Glass Patents (Class 210/500.26)
  • Patent number: 10434509
    Abstract: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 8, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Joseph Amshey, Daniel Bezdek, Espir Kahatt, Alexander Khorlin, Lance Parsons, Todd Peterson, Timothy Powers, Michael Thacker, Timothy Updyke, Kornelija Zgonc
  • Patent number: 10092902
    Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: October 9, 2018
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
  • Patent number: 9926552
    Abstract: The present invention relates to a microfluidic device for extracting and isolating DNA from cells. The device includes a support having an inlet port for receiving a sample containing a cell, an outlet port for dispensing DNA isolated from the cell, and a microfluidic channel disposed within the support and extending from the inlet port to the outlet port. The microfluidic channel includes a micropillar array, an inflow channel disposed between the inlet port and the micropillar array, and an outflow channel disposed between the micropillar array and the outlet port. The micropillar array includes micropillars spatially configured to entrap, by size exclusion, the cell, to immobilize DNA released from the cell, and to maintain the immobilized DNA in elongated or non-elongated form when hydrodynamic force is applied to the microfluidic channel. Systems and methods of making and using the device are also provided herein.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: March 27, 2018
    Assignee: CORNELL UNIVERSITY
    Inventors: Harold G. Craighead, Juraj Topolancik, Harvey Tian, Christopher Wallin
  • Patent number: 9522351
    Abstract: A filtration element for filtering a fluid medium comprising a rigid porous support of cylindrical shape having a longitudinal central axis (A) and comprising a plurality of channels for the circulation of the fluid medium to be filtered with a view to recovering a filtrate at the periphery of the support. The channels are parallel to a central axis of the support. The channels have at least three filtration crowns, characterized in that at the three crowns closest to the periphery of the support there is at least a substantial alignment of 3 adjacent axes among the axes of the flow and connection paths and the axes of the channels, which favors the mechanical strength of the support.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: December 20, 2016
    Assignee: TECHNOLOGIES AVANCEES ET MEMBRANES INDUSTRIELLES
    Inventor: Philippe Lescoche
  • Patent number: 9506028
    Abstract: The present invention relates to a cell lysis apparatus and a manufacturing method thereof, and more particularly, to a cell lysis apparatus, which mechanically performs cell lysis, and a manufacturing method thereof. The cell lysis apparatus includes: an inlet port through which fluid containing cells is supplied; a fluid channel defining a passage through which the cell containing fluid supplied from the inlet port flows; a nano blade array including a plurality of nano blades having pointed leading ends and arranged such that the pointed leading ends of the nano blades are oriented in a direction of the fluid supplied through the inlet port to disrupt the cells passing therethrough; and an outlet port through which the disrupted cells and the fluid are discharged.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: November 29, 2016
    Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sung Yang, Sung Sik Yun, Sang Youl Yoon
  • Publication number: 20150083659
    Abstract: A bicomponent fiber is disclosed, in addition to systems and processes for making the bicomponent fiber. The bicomponent fiber can include a glass core and a polytetrafluoroethylene (PTFE) sheath circumferentially enclosing the glass core, wherein the bicomponent fiber has a diameter between approximately five micrometers and approximately twenty micrometers.
    Type: Application
    Filed: September 25, 2013
    Publication date: March 26, 2015
    Applicant: BHA Altair, LLC
    Inventors: Vishal Bansal, Jeffery Michael Ladwig
  • Patent number: 8956437
    Abstract: Articles such as filter media, which include dendrimers and/or other components, are provided. The filter media may further include a water repellant (e.g., a fluorinated species) to impart desirable properties to the media such as high water repellency. The filter media may also have a high efficiency as a function of pressure drop (i.e., high gamma values). In some embodiments, the filter media includes a fiber web which may be formed of various components such as glass fibers. The fiber web can also include additional components such as synthetic fibers, binder components, as well as other additives. The media may be incorporated into a variety of filter element products.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: February 17, 2015
    Assignee: Hollingsworth & Vose Company
    Inventors: David F. Sealey, Stuart Williams
  • Patent number: 8940521
    Abstract: A composite detection device having in-line desalting is provided. The composite detection device comprises a membrane configured for desalting at least a portion of an analyte stream, and a nanostructure for detecting a bio-molecule or a bio-molecule interaction, wherein the nanostructure and the membrane are arranged such that an analyte stream desalted at least in part by the membrane is detected by the nanostructure. A bio-sending detection system having the composite detection device and method of fabrication of the composite detection device are also provided.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: January 27, 2015
    Assignee: General Electric Company
    Inventors: Anthony John Murray, Anping Zhang, Rui Chen
  • Publication number: 20150008180
    Abstract: An object of the present invention is to provide a honeycomb shaped porous ceramic body in which a strength deteriorates less than before after a separation layer is formed, a manufacturing method for the porous ceramic body, and a honeycomb shaped ceramic separation membrane structure. A honeycomb shaped porous ceramic body 9 includes a honeycomb shaped substrate 30 and an intermediate layer. At least a part of the intermediate layer of the honeycomb shaped porous ceramic body 9 has a structure in which aggregate particles are bonded to one another by a component of an inorganic bonding material. The inorganic bonding material is titania.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Inventors: Tetsuya UCHIKAWA, Makoto MIYAHARA, Makiko ICHIKAWA, Kenji YAJIMA, Makoto TERANISHI, Hideyuki SUZUKI
  • Publication number: 20140367326
    Abstract: The present invention is directed to a filtration membrane comprising a thin polymeric membrane film in which mesoporous silica nanoparticles are embedded. The membrane may be a thin-film nanocomposite membrane useful for reverse osmosis or nanofiltration. The present invention is also directed to a filtration membrane comprising a thin polymeric membrane film formed from a solution comprising less than 0.1 wt % mesoporous nanoparticles.
    Type: Application
    Filed: June 16, 2014
    Publication date: December 18, 2014
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: BAOLIN DENG, JUN YIN
  • Patent number: 8911687
    Abstract: A miniature sieve apparatus is described and includes a first sieve, a separator and a second sieve from top to bottom. The first and second sieves are formed with at least one first mesh and a plurality of second meshes, respectively. The first and second meshes are misaligned with each other in a vertical direction of the first and second sieves. The miniature sieve apparatus is provided to separate or screen microparticles with different sizes, such as target cells, bio-medical particles, organic or inorganic microparticles. Additionally, the invention also provides a manufacturing method of the miniature sieve apparatus, and the same material is applied to manufacture the sieves and the separators. Thus, the problem caused by the residual thermal stress due to different material can be solved. Therefore, the cost of the miniature sieve apparatus can be lowered as the yield rate thereof is improved.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: December 16, 2014
    Assignee: National Applied Research Laboratories
    Inventors: Chun-ming Huang, Chen-chia Chen, Chi-sheng Lin, Chien-ming Wu
  • Publication number: 20140339168
    Abstract: A ceramic membrane for separating oil from water. The membrane contains a ceramic substrate having pore channels, and carbon nanotubes extending from surfaces of the ceramic substrate, wherein the ceramic substrate has a thickness of 0.1 to 50 mm and a porosity of 5 to 95%, the pore channels have a diameter of 0.001 to 20 ?m, and the carbon nanotubes constitute 0.01 to 40% by weight. Also disclosed are a method of preparing this membrane and a method of using it.
    Type: Application
    Filed: September 12, 2012
    Publication date: November 20, 2014
    Applicant: National University of Singapore
    Inventors: Liang Hong, Xinwei Chen
  • Publication number: 20140332459
    Abstract: The invention provides a novel type of filter media that offers efficient disinfection effects, while achieving a low water pressure drop and a high water flow rate when in use. Specifically, the filter media of the invention comprises a microorganism-killing membrane containing electro spun nanofiber fabrics loaded with biocidal nano-particles. The filter media of the invention is adhesive-layer free and contains at least one thermal binding layer that are made of spunbonded nonwoven polymeric fabrics. The invention also provides a water-purification cartridge and a portable water system thereof.
    Type: Application
    Filed: May 10, 2013
    Publication date: November 13, 2014
    Applicant: Goodrich Corporation
    Inventor: Jin Hu
  • Publication number: 20140331860
    Abstract: There is disclosed a ceramic separation membrane. This ceramic separation membrane includes a porous substrate, and a separation layer formed on the substrate. The separation layer is a laminate having an outermost layer positioned on the most surface side, and a base layer positioned in a lower layer than the outermost layer and made of zeolite. The outermost layer is a layer made of a siliceous material containing 90 mol % or more of silica, an organic material-containing amorphous silica material having a Si-Cn-Si (wherein n is 1 or 2) bond and a Si/C ratio of 0.5 to 2, or a carbonaceous material containing 90 mass % or more of carbon. The outermost layer is different from the base layer.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Manabu ISOMURA, Naoto KINOSHITA, Naoko INUKAI
  • Publication number: 20140319047
    Abstract: The disclosure provides a filtration material and a method for fabricating the same. The filtration material includes a supporting layer, and a composite layer, wherein the composite layer includes an ionic polymer and an interfacial polymer. Particularly, the ionic polymer and the interfacial polymer are intertwined with each other, resulting from ionic bonds formed between the ionic polymer and the interfacial polymer.
    Type: Application
    Filed: April 23, 2014
    Publication date: October 30, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Shu-Hui CHENG, Wei-Cheng TSAI, Shan-Shan LIN, Yu-Chuan HSU, Yin-Ju YANG
  • Patent number: 8833567
    Abstract: A coalescence media for separation of water-hydrocarbon emulsions comprises an emulsion-contacting sheet formed of: (a) at least one component of the group consisting of natural fibers, cellulose fibers, natural-based fibers, and cellulose-based fibers, at least one component of the group consisting of high-surface-area fibrillated fibers, surface-area-enhancing synthetic material, glass microfibers, and nanoceramic functionalized fibers; and (c) at least one component of the group consisting of a dry strength additive, and a wet strength additive, wherein the fibrous components of the media constitute at least about 70% of the media. In preferred embodiments, the coalescence media comprises kraft fibers, fibrillated lyocell fibers, glass microfibers or nanoceramic functionalized fibers, a wet strength additive, and a dry strength additive. Preferably, the coalescence media is formed as a single, self-supporting layer from a wet-laid process using a homogenously distributed, wet-laid furnish.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: September 16, 2014
    Assignee: Ahlstrom Corporation
    Inventors: Christine Stanfel, Frank Cousart
  • Publication number: 20140197103
    Abstract: Components, systems, and methods for producing highly hydrophilitic, functionalized inorganic filtration membranes, pre-treating organic and biological-containing waste waters for minimal membrane fouling and scaling when processed using such functionalized membranes, and use of such functionalized membranes of the present invention in filtration systems for separating such pre-treated waste waters, all with respect to optimal permeate production rates, purity of permeate and resistance to fouling and scale formation on the membranes.
    Type: Application
    Filed: November 19, 2013
    Publication date: July 17, 2014
    Applicant: Lance Energy Services, LLC
    Inventors: Waymon R. Votaw, Jacob L. Davis, Edward E. Munson, Andrew Barron, Samuel J. Maguire-Boyle
  • Patent number: 8678201
    Abstract: A potable water system (10) comprises a supply line (18) and a water-purification device (20) incorporated thereinto. The water-purification device (20) comprises a microorganism filter (40) having a housing (42) and replaceable cartridge (42). The cartridge's filter media (50) includes a microorganism-capturing membrane (e.g., comprising an electropositive material) and a microorganism-killing membrane (e.g., comprising a biocidal material).
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: March 25, 2014
    Assignee: Goodrich Corporation
    Inventor: Jin Hu
  • Publication number: 20140054228
    Abstract: The present disclosure describes an additive that may be used in the manufacture of thin-film polyamide composite membranes. Thin-film polyamide composite membranes are used in filtration processes, such as reverse osmosis and nanofiltration. The additive may be an amino-siloxane compound. The amino-siloxane compound includes repeated groups of silicon bonded to oxygen with at least one amine functional group. Optionally, the amino-siloxane compound may also include a hydrophilic group. The additive reacts with an aqueous phase and an organic phase to form a thin polyamide film on a porous substrate.
    Type: Application
    Filed: August 21, 2012
    Publication date: February 27, 2014
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Xingpeng ZHANG, Lawrence C. COSTA, Steven John HARROLD, Babu NARAYANSWAMY
  • Publication number: 20140021129
    Abstract: There is provided a honeycomb-shaped ceramic separation-membrane structure having higher pressure resistance than conventional ones and being capable of reducing production costs. The honeycomb-shaped ceramic separation-membrane structure (1) is provided with a honeycomb-shaped base material (30), an intermediate layer, and a separation layer. At least part of a ceramic porous body (9) has a structure where aggregate particles are bonded to one another by an inorganic bonding material component. In the ceramic separation-membrane structure (1), an internal pressure fracture strength capable of fracturing the structure by application of water pressure inside the cells (4) is 7 MPa or more.
    Type: Application
    Filed: September 19, 2013
    Publication date: January 23, 2014
    Applicant: NGK Insulators, Ltd.
    Inventors: Makoto TERANISHI, Makoto MIYAHARA, Makiko ICHIKAWA, Hideyuki SUZUKI
  • Patent number: 8607992
    Abstract: A ceramic filter comprising: (a) from about 75% to about 95% by weight of diatomaceous earth; (b) from about 10% to about 20% by weight of a flux; and (c) from about 0.03% to about 0.4% by weight of a metallic compound; the percentages by weight being percentages by weight of the ceramic filter.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: December 17, 2013
    Assignee: Aqua-Nu Filtration
    Inventors: Patrick Farrelly, Sean McCormack, Robert Verkerk, David Maybin
  • Publication number: 20130284667
    Abstract: Polymer composite membranes containing mesoporous particles which function in part as reinforcing agents, modifiers of polymer surface polarity, and membrane structure modifiers are provided. The composites provide superior resistance to internal damage and pore compaction, increased permeability to water with retention of separation fidelity, and resistance to chemical degradation and mechanical wear, along with minimal shedding of the reinforcing particles under applied pressure. These improvements in properties are particularly desirable for the water purification by membrane filtration methods.
    Type: Application
    Filed: January 9, 2013
    Publication date: October 31, 2013
    Inventors: Thomas J. Pinnavaia, Volodymyr V. Tarabara
  • Publication number: 20130270188
    Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. The filters may include at least one active layer disposed on a porous substrate. The at least one active layer may include intrinsic and/or intentional formed pores. In some embodiments, the flow resistance of the porous substrate may be selected to limit flow through defects and intrinsic pores in the at least one active layer.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 17, 2013
    Inventors: Massachusetts Institute of Technology, King Fahd University of Petroleum & Minerals
  • Patent number: 8528747
    Abstract: Solid phase extraction (SPE) disks may be manufactured by providing a suspension comprising glass microfibers and a suspension comprising one or more sorbents and forming a disk by combining the suspensions or by layering the suspensions. This may be followed by a drying procedure to create the finished disk. A disk mold including a collar and plug may be used to establish the size and shape of the disk. Examples of various constructions and processes for forming the disks are provided.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: September 10, 2013
    Assignee: Horizon Technologies, Inc.
    Inventors: Kevin Dinnean, Robert S. Johnson, Steve J. MacDonald
  • Patent number: 8486176
    Abstract: A method for filtering molten aluminum and aluminum alloys. The method includes providing a reticulated foam wherein oxygen is introduced to an interior of the reticulated foam. Molten aluminum or aluminum alloy is passed through the reticulated foam wherein oxygen is maintained at a partial pressure of at least 2.51×10?35 atm during filtration.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: July 16, 2013
    Assignee: Porvair PLC
    Inventor: Leonard S. Aubrey
  • Publication number: 20130146521
    Abstract: Stabilized surfactant-based membranes and methods of manufacture thereof. Membranes comprising a stabilized surfactant mesostructure on a porous support may be used for various separations, including reverse osmosis and forward osmosis. The membranes are stabilized after evaporation of solvents; in some embodiments no removal of the surfactant is required. The surfactant solution may or may not comprise a hydrophilic compound such as an acid or base. The surface of the porous support is preferably modified prior to formation of the stabilized surfactant mesostructure. The membrane is sufficiently stable to be utilized in commercial separations devices such as spiral wound modules. Also a stabilized surfactant mesostructure coating for a porous material and filters made therefrom. The coating can simultaneously improve both the permeability and the filtration characteristics of the porous material.
    Type: Application
    Filed: November 23, 2012
    Publication date: June 13, 2013
    Applicant: ZNANO LLC
    Inventor: zNano LLC
  • Patent number: 8449772
    Abstract: A micro fluidic system comprising at least one tube (1), a membrane (3) and at least one fitting member (4). The fitting member (4) is positioned around the membrane (3) and an end part (2) of the tube(s) (1), thereby fitting the membrane (3) to the end part(s) (2). The fitting member(s) (4) is/are made from a shrinkable material, and it/they is/are fitted tightly around the membrane (3) end part(s) (2). This is obtained by causing the shrinkable material to shrink, e.g. by heating the material, while the fitting member (4) is positioned around the membrane (3) and the end part(s) (2). It is an advantage that the fitting member (4) is made from a shrinkable material because this provides the possibility of fitting the membrane (3) tightly to the end part(s) (2) in an easy and cost effective manner. The micro fluidic system is very suitable for use in a probe, such as a dialysis probe. Also claimed is a method of manufacturing the micro fluidic system.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: May 28, 2013
    Assignee: Flowsion ApS
    Inventors: Holger Dirac, Per Brandt Rasmussen, Arne Briest
  • Publication number: 20130075324
    Abstract: An objective of the invention disclosure is to provide a composite porous film that has both a sufficient chemical resistance and strength allowing suppression of heat deflection under a liquid at a high temperature, and a filter using the same; the composite porous film for fluid separation to be provided according to the invention includes a fluoropolymer resin and a SiO2 glass.
    Type: Application
    Filed: June 17, 2011
    Publication date: March 28, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Kazuyuki Sakamoto, Osamu Kojima, Osamu Yamaguchi
  • Patent number: 8404194
    Abstract: Disclosed is a separation media, comprising an upstream layer, comprising fibers, wherein the upstream layer has a mean flow pore size of 8 microns or less; and a downstream layer, comprising fibers. The separation media is designed to separate red blood cells from liquid specimens such as blood and allow a filtrate, such as blood plasma, to flow from said downstream layer. Also provided is a diagnostic test device incorporating the separation media. Further disclosed is a method for separating red blood cells from a liquid specimen.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: March 26, 2013
    Assignee: Lydall, Inc.
    Inventors: Abhishek D. Saxena, John C. Ramsay
  • Publication number: 20130056415
    Abstract: A negatively charged microporous filtration medium having a high charge density comprising a porous substrate and a polymerized cross-linked polymeric coating located on the inner and outer surfaces of the substrate. The coating may be formed from a reactant solution comprising negatively charged cross-linkable polymerizeable acrylamidoalkyl monomers and acrylamido cross-linking agents which are polymerized in situ on the substrate. The negatively charged microporous filtration medium are suitable for use as prefiltration membranes for selectively removing protein aggregates from a protein solution.
    Type: Application
    Filed: February 26, 2010
    Publication date: March 7, 2013
    Inventors: Mikhail Kozlov, Kevin Rautio
  • Publication number: 20130026088
    Abstract: Described herein is a method for altering the characteristics of a membrane comprising a dielectric material. The method comprises heating the membrane and applying an electric field in a direction out of the plane of the membrane to at least a portion of the dielectric material. At least a portion of the dielectric material becomes aligned with the applied electric field. In some embodiments, the membrane is piezoelectric and application of an electric signal to the membrane causes out of plane movement of the membrane. Also disclosed are membranes and systems and apparatuses comprising such membranes.
    Type: Application
    Filed: November 25, 2010
    Publication date: January 31, 2013
    Inventors: Hans Gerard Leonard Coster, Tahereh Darestani Farahani, Terry Calvin Chilcott
  • Patent number: 8361197
    Abstract: There is provided a zeolite separation membrane-provided article having gaps or pores larger than pores inherent to zeolite crystals and controlled within an appropriate range and being capable of achieving both high permeability and high separability for components with small difference in adsorption properties or a component having a smaller molecular diameter than the diameter of the pores, a method for producing the same, a method for separating mixed fluids, and a device for separating mixed fluids. The zeolite separation membrane-provided article is provided with a zeolite membrane having an N2 gas permeation speed at room temperature of 1.0×10?6 mol·m?2·s?1·Pa?1 or more and a permeation speed ratio of 1,3,5-trimethylbenzene/N2 at room temperature of 0.17 or more and being free from dyeing caused by the impregnation with Rhodamine B.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: January 29, 2013
    Assignee: NGK Insulators, Ltd.
    Inventors: Masaaki Kawai, Toshihiro Tomita, Nobuhiko Mori, Aya Satoh
  • Publication number: 20120318731
    Abstract: The invention relates to a membrane for the microfiltration or ultrafiltration of liquid fluids, in particular for the microfiltration or ultrafiltration of water or for the filtration of nanoparticles containing fluids. The membrane is characterized in that the membrane comprises, in particular electrospun, nanofibers, wherein the nanofibers are functionalized with proteins. Moreover, the invention relates to a method for producing a membrane for the microfiltration or ultrafiltration of liquid fluids, in particular for the microfiltration or ultrafiltration of water or for the filtration of nanoparticles containing fluids. Furthermore, the invention relates to a use of a microfiltration or ultrafiltration membrane.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 20, 2012
    Applicant: Helmholtz-Zentrum Geesthacht Zentrum fur Material- und Kustenforschung GmbH
    Inventors: Mady Elbahri, Seyed Shahin Homaeigohar, Tianhe Dai, Ramzy Abdelaziz
  • Publication number: 20120292255
    Abstract: This disclosure provides methods to use nanoparticles as non-optical tags for detecting a change in mass. chemical sensing or bio-sensing events or reaction upon conjugation of nanoparticles onto a thermoresistor heat sensor. Particularly described is the use of metal nanoparticles in thermal sensors, thermal bio-sensors, and sensing pixel arrays for multiple analyte sensing. In addition, an asymmetric filter is disclosed that allows size separation of molecules from nanoparticles. The asymmetric filter is a porous membrane that is designed to have a small pore size in one size and a large pore size on the other side.
    Type: Application
    Filed: May 16, 2012
    Publication date: November 22, 2012
    Inventor: Babak Nikoobakht
  • Patent number: 8297449
    Abstract: A filter includes a membrane having a plurality of nanochannels formed therein. Functionalized nanoparticles are deposited through self assembly onto surfaces defining the nanochannels so as to decrease the final diameter of the membrane. Methods for making and using the filter are also provided.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: October 30, 2012
    Assignee: International Business Machines Corporation
    Inventors: Ali Afzali-Ardakani, Stephen M. Rossnagel
  • Publication number: 20120261343
    Abstract: Various aspects of the present invention pertain to porous membranes that comprise: (1) a plurality of pores with pore sizes of more than about 0.1 ?m in diameter; and (2) a plurality of hydrophilic molecules. Additional aspects of the present invention pertain to methods of separating organic compounds from a liquid sample by: (1) providing the porous membrane; and (2) flowing the liquid sample through the porous membrane in order to retain organic compounds on the porous membrane. Further aspects of the present invention pertain to systems for separating organic compounds from a liquid sample. Such systems comprises: (1) the porous membrane; and (2) a flowing unit that enables the liquid sample to flow through the porous membrane. Additional aspects of the present invention pertain to methods of making the above-described porous membranes by: (1) coating a surface of a porous membrane containing 0.
    Type: Application
    Filed: April 15, 2011
    Publication date: October 18, 2012
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Andrew R. Barron, Samuel J. Maguire-Boyle
  • Patent number: 8288170
    Abstract: The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: October 16, 2012
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Siyang Zheng, Henry Lin, Ram Datar, Richard Cote
  • Patent number: 8277661
    Abstract: A hydrothermally stable, microporous organic-inorganic hybrid membrane based on silica, having an mean pore diameter of between 0.2 and 1.5 nm, is characterised in that between 5 and 40 mole % of the Si—O—Si bonds have been replaced by moieties having the one of the formulas: Si—{[CmH(n-1)X]—Si—}q, Si—[CmH(n-2)X2]—Si or Si—CmHn—Si{(CmHn)—Si—}y in which m=1-8, n=2m, 2m?2, 2m?4, 2m?6 or 2m?8; provided that n?2, X=H or (CH2)pSi, p=0 or 1, and q=1, 2, 3 or 4. The membrane can be produced by acid-catalysed hydrolysis of suitable bis-silane precursors such as bis(trialkoxysily)alkanes, preferably in the presence of monoorganyl-silane precursors such as trialkoxy-alkylsilanes.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: October 2, 2012
    Assignee: Stichting Energieonderzoek Centrum Nederland
    Inventors: Ashima Sah, Hessel Lennart Castricum, Jaap Ferdinand Vente, David Hermanus Adrianus Blank, Johan Evert Ten Elshof
  • Publication number: 20120234750
    Abstract: A thermally, heat and chemically stable polyimide asymmetric ultrafiltration membrane, is a porous film or a hollow fiber, having an anisotropic structure a selective surface layer and a substrate, wherein the selective ultraporous surface layer has size of pores 70-800 ? with thickness 0.1-10 mcm and is composed of insoluble rigid-chain aromatic (co)polyimide based on dianhydride of aromatic tetracarbonic acid and aromatic diamine and located on the microporous substrate with thickness 50-250 mcm, and the membrane has water permeability Q=(2-500)·10?4 cm/sec atm and nominal molecular weight cutoff ML=(5-500)·103 g/mol, and method for producing an ultrafiltration membrane as disclosed.
    Type: Application
    Filed: May 30, 2012
    Publication date: September 20, 2012
    Inventors: Galina A. Polotskaya, Tamara K. Meleshko, Alexandr E. Polotsky, Andrey N. Cherkasov
  • Publication number: 20120228214
    Abstract: A porous membrane may have a high concentration of spherical fillers with a polymer binder. The polymer binder may have an affinity for the filler materials and may hold the filler materials together in a porous structure with high tortuosity and consistent pore size. The membrane may be manufactured with a reinforcing web, such as non-woven web. The membrane may be greater than 50% porous with a less than 1 micron pore size. Within the pore walls that may be less than 0.02 microns in width, a densely packed filler material may have an average diameter of less than 0.005 microns.
    Type: Application
    Filed: March 13, 2012
    Publication date: September 13, 2012
    Applicant: POROUS POWER TECHNOLOGIES
    Inventors: Kirby W. Beard, Ann M. Edwards
  • Patent number: 8231013
    Abstract: Articles comprising a fibrous support of nanofibers and an interfacially polymerized polymer layer disposed on a surface of the fibrous support are useful, e.g., as fluid separation membranes.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: July 31, 2012
    Assignee: The Research Foundation of State University of New York
    Inventors: Benjamin Chu, Benjamin Hsiao, Kyunghwan Yoon
  • Patent number: 8088282
    Abstract: Disclosed herein are an apparatus and a method for separating molecules on the basis of size and or structure, and to a method of making the apparatus. Generally, the separation method includes passing a fluid comprising particles having different effective molecular diameters through a plurality of open, nanoscale channels disposed in surfaces of substrates. The method also includes obtaining a plurality of fractions of the passed fluid such that each of the fractions includes a major portion containing particles having similar size and shape and substantially free of particles having larger size and shape. The apparatus includes first and second substrates each of which has a surface containing a plurality of open, nanoscale channels disposed therein. The surfaces are bonded together such that each of the channels of the first substrate is in fluid communication with at least two of the channels of the second substrate and is misaligned relative to the channels of the second substrate.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: January 3, 2012
    Assignee: Intel Corporation
    Inventor: Scott Sibbett
  • Publication number: 20110297609
    Abstract: A potable water system (10) comprises a supply line (18) and a water-purification device (20) incorporated thereinto. The water-purification device (20) comprises a microorganism filter (40) having a housing (42) and replaceable cartridge (42). The cartridge's filter media (50) includes a microorganism-capturing membrane (e.g., comprising an electropositive material) and a microorganism-killing membrane (e.g., comprising a biocidal material).
    Type: Application
    Filed: February 22, 2011
    Publication date: December 8, 2011
    Inventor: Jin Hu
  • Patent number: 8057672
    Abstract: Provided is a disposable multi-layered filtration device for the separation of blood plasma which can be applied to a biochip and appropriate for disposal uses. The filtration device for the separation of blood plasma includes: an upper substrate including a blood inlet; an intermediate substrate including a filtering unit for extracting blood plasma from blood flowing through the blood inlet; and a lower substrate including an air outlet, wherein the upper substrate, the intermediate substrate, and the lower substrate are stacked and adhered.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: November 15, 2011
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Kwang Hyo Chung, Yo Han Choi, Dae Sik Lee, Ju Hyun Jeon, Moon Youn Jung, Seon Hee Park
  • Publication number: 20110259825
    Abstract: A microporous organic-inorganic hybrid membrane based on silica of the invention has an average pore diameter of less than 0.6 nm, and comprises bridging organosilane moieties of the formula ?O1.5Si—CHR—SiO1.5? or ?O1.5Si—CH(CH3)—SiO1.5?. The membrane can be used in the separation of hydrogen from mixtures comprising hydrogen and CH4, CO2, CO, N2, and the like, and in the separation of water from alcohols having 1-3 carbon atoms, optionally in the presence of an inorganic or organic acid.
    Type: Application
    Filed: July 14, 2009
    Publication date: October 27, 2011
    Inventors: Rob Kreiter, Hessel Lennart Castricum, Jaap Ferdinand Vente, Johan Evert Ten Elshof, Maria Dirkje Anna, Henk Martin Veen
  • Publication number: 20110100910
    Abstract: The invention relates to a ceramic dead-end filter for filtration of liquid. The ceramic dead-end filter comprises at least one ceramic filter membrane having a first side with a front surface and a second side. The ceramic membrane comprises a selective front layer providing said front surface and the selective front layer comprises a maximum pore size diameter of about ?m or smaller, for example between about 0.5 nm and about 25 ?m. The ceramic dead-end filter of the invention provides an effective filtration with a high flux and a long durability. The filter can furthermore be regenerated in a simple way. The invention also relates to filtration system comprising such ceramic dead-end filter, a method of performing the filtration process as well as a method of producing the filter.
    Type: Application
    Filed: April 14, 2009
    Publication date: May 5, 2011
    Applicant: COMETAS A/S
    Inventors: Kenneth Hojrup Johansen, Jens Husted Kjaer
  • Patent number: 7906026
    Abstract: Disclosed herein are an apparatus and a method for separating molecules on the basis of size and or structure, and to a method of making the apparatus. Generally, the separation method includes passing a fluid comprising particles having different effective molecular diameters through a plurality of open, nanoscale channels disposed in surfaces of substrates. The method also includes obtaining a plurality of fractions of the passed fluid such that each of the fractions includes a major portion containing particles having similar size and shape and substantially free of particles having larger size and shape. The apparatus includes first and second substrates each of which has a surface containing a plurality of open, nanoscale channels disposed therein. The surfaces are bonded together such that each of the channels of the first substrate is in fluid communication with at least two of the channels of the second substrate and is misaligned relative to the channels of the second substrate.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: March 15, 2011
    Assignee: Intel Corporation
    Inventor: Scott Sibbett
  • Patent number: 7866486
    Abstract: Composites comprising at least one hollow fiber of oxygen-transporting ceramic material, which is a ceramic material which conducts oxygen anions and electrons or a combination of ceramic material which conducts oxygen anions and a ceramic or nonceramic material which conducts electrons, with the outer surface of the hollow fiber being in contact with the outer surface of the same hollow fiber or another hollow fiber and the contact points being joined by sintering, are described. Further composites comprise at least one hollow fiber of oxygen-transporting ceramic material which is a ceramic material which conducts oxygen anions and electrons or a combination of ceramic material which conducts oxygen anions and ceramic or nonceramic material which conducts electrons and a connection element for the introduction or discharge of fluids at at least one end face, with hollow fibers and connection element being joined.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: January 11, 2011
    Assignees: Uhde GmbH, BORSIG Process Heat Exchanger GmbH
    Inventors: Steffen Werth, Nicole Dinges, Mirjam Kilgus, Thomas Schiestel
  • Patent number: 7846393
    Abstract: The present invention provides a parylene-based membrane filter device for capturing of circulating tumor cells (CTC). The membrane filter has an array of holes having a predetermined geometric design with precisely controlled size, shape and density. In one aspect, the device has a stack of substantially parallel membrane filters with uniformly-spaced and/or monodispersed holes.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: December 7, 2010
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Siyang Zheng, Henry Lin, Ram Datar, Richard Cote
  • Patent number: 7846743
    Abstract: The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene membrane filters with high figures of merit and finely controlled hole sizes allows the separation of cells and particles in a variety of biological and other fluids according to sizes.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: December 7, 2010
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Siyang Zheng, Henry Lin, Ram Datar, Richard Cote