Abstract: Concentrated methotrexate solutions are described which are suitable for the use of an active substance in the production of a parenterally administered medicament for the treatment of inflammatory autoimmune diseases. The methotrexate is added to a pharmaceutically acceptable solvent at a concentration of more than 25 mg/ml.

Abstract: A device for dispensing a liquid may include a basin defining a reservoir, a pump including a barrel and a spring, the barrel coupled to the basin, the barrel defining a cavity, and the spring disposed in the cavity, and an actuator at least partially disposed in the reservoir, the actuator defining a first orifice, a second orifice, and a lumen extending between the first orifice and the second orifice, the reservoir in fluid communication with the lumen via the first orifice, the actuator depressible to move the second orifice in a first direction defined from the reservoir toward the cavity of the barrel, and the spring of the pump biasing the actuator to move in a second direction defined from the cavity of the barrel toward the reservoir.

Abstract: The present invention relates to a composition of a hot-melt adhesive film and a method for producing a shoe sole. The composition of the hot-melt adhesive film comprises a hot-melt adhesive material and an electromagnetic radiation absorbing material. The hot-melt adhesive material includes ethylene vinyl acetate and thermoplastic materials. The electromagnetic radiation absorbing material is uniformly dispersed in the hot-melt adhesive material. Energy of an electromagnetic radiation can be absorbed by the electromagnetic radiation absorbing material, thereby producing thermal energy, further increasing temperature and adhering property of the hot-melt adhesive film. Therefore, a midsole and an outsole of the shoe sole can be adhered by the hot-melt adhesive film. Further, the hot-melt adhesive film is made from recyclable materials. Therefore, the hot-melt adhesive film is fully recyclable.

Abstract: A dispenser for discharging flowable compounds has a reservoir for holding the compound and a dispensing pump. The dispenser has a longitudinal axis. The dispensing pump has an inflow and an outflow channel, a pumping chamber which is delimited on the inflow and outflow sides by valves, and a head piece. The head piece has a dispensing opening. A pumping part can be moved relative to a cup part against an elastic force of a restoring device in order to achieve a pumping stroke, and the head piece is coupled to the pumping part with respect to motion such that a motion of the head piece from a completely depressed position to a reachable extension height corresponds to the pumping stroke. A variable limiting device is provided for variably limiting the pumping stroke and a change in the pumping stroke corresponds to a change in the extension height.

Abstract: Embodiments relate to an intranasal drug delivery device, system, and process. The drug delivery device can have a compliant/flexible soft nib. The drug delivery device can have an actuator and shot chamber. The drug delivery device can have a non-air interface mechanically pressurized fluid reservoir. The drug delivery device can have a facial or device recognition application to prevent intentional or unintentional misuse.

Abstract: The present invention provides a glue gun, comprising a movable handle and a fixed handle, wherein the movable handle is connected to fixed handle via a pivot pin shaft; the movable handle is further provided with an actuating member, and the actuating member is provided with an actuating part cooperating with a push member; and a spacing between the pivot pin shaft and the actuating part is sized to be switchable between two or more gears, such that the magnitude of the force applied by the actuating member on the push member is changed. The gear in the present invention can be adjusted to enable switching between a fast feed and a powerful feed, thereby enabling a user to make adjustment according to actual requirements.

Abstract: A drive mechanism for a drug delivery device having a rotationally fixed plunger rod driven by a lead screw. The lead screw engages a free lock which is coupled to a release knob. A dose setting dial cooperates with an inner cylinder using a clutch to establish the axial movement of the plunger rod during dose setting and dispensing.

Abstract: A dispenser having a fluid reservoir (1); a dispenser member (2) having a body (21) and an actuator rod (22) movable over a maximum rod stroke; a dispenser orifice (46); a rotary actuator member (4); a transmission member (5) that is engaged both with the dispenser member (2) and also with the rotary actuator member (4); and a cam mechanism (43, 55) for transforming turning of the rotary actuator member (4) into an axial movement of the actuator rod (22) or of the body (21). The cam mechanism (43, 55) defines a maximum cam stroke that is greater than the maximum rod stroke; and a resilient mechanism (56) acts axially to compensate for the extra amount of the maximum cam stroke and thus allow it to be followed so as to guarantee that the rod performs its maximum stroke in full.

Abstract: An injection device comprises a housing, a dose indicator positioned within the housing and a dose selector operatively connectable to the dose indicator. The dose selector and the dose indicator are capable of cooperating with one another to set a dose to be ejected from the injection device. The dose indicator comprises an odometer including: i. a units (218) wheel operatively connected to the dose selector so that rotation of the dose selector also rotates the units wheel, and ii. a tens wheel (219) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. The dose indicator further comprises an axially-moveable shuttle lock (222) rotationally locked to the tens wheel and selectively engageable with the units wheel and the housing. The tens wheel is selectively engageable with the units wheel via said shuttle lock and, when the tens wheel is not engaged with the units wheel, the shuttle lock is rotationally locked to the housing.

Abstract: A dual dispensing pack includes a dual dispensing pump head having a first pumping assembly and a second pumping assembly. The first pumping assembly is operatively coupleable to a first bottle and the second pumping assembly is operatively coupleable to a second bottle. The first pumping assembly includes a first piston, and the second pumping assembly includes a second piston. A stroke length of the first piston is the same as a stroke length of the second piston, and a volume dispensed by the first pump assembly is independently varied from a volume dispensed from the second pump assembly.

Abstract: Exemplary embodiments of pumps, refill units and dispenser systems are disclosed herein. An exemplary refill unit for a soap, sanitizer or lotion includes a container for holding a fluid and a pump secured to the container. The pump includes a housing, a liquid piston, a liquid pump chamber, an air piston, an air pump chamber; and a piston holder. The liquid piston is connected to the air piston. The piston holder is connected to one of the liquid piston and the air piston. The connection comprises one or more projections and one or more grooves. The volume of the liquid pump chamber and the air pump chamber both change as a function of the engagement of the one or more projections with the one or more grooves.

Abstract: A receptacle section for an aerosol provision article is described. The aerosol provision article is for generating a flow of aerosol in use. The receptacle section is arranged for having installed therein an activatable element for modifying, once activated, a property of the flow of aerosol. The receptacle section is arranged to apply, on installation of the activatable element in the receptacle section by a user, a force to the activatable element to activate the activatable element.

Abstract: The present invention relates to a drug delivery device for dispensing of a dose of a medicament, comprising a housing to accommodate a cartridge being at least partially filled with a medicament, wherein the housing comprises a dispensing end with an access opening which is closed by a tamper-evident closure.

Abstract: The liquid material ejector has a liquid material supply port through which the liquid material is supplied, a nozzle for ejecting the liquid material, a valve block having a metering bore to be filled with the ejected liquid material and a liquid material supply channel communicating with the liquid material supply port, a selector valve having a first channel for allowing communication between the metering bore and the liquid material supply channel and a second channel for allowing communication between the metering bore and the nozzle, a plunger advancing and retracting in the metering bore, a plunger driving section for driving the plunger, a valve driving section for driving the selector valve, and a transmission section for transmitting driving power from the valve driving section to the selector valve. The plunger driving section, the valve driving section, and the valve block are arranged successively in the longitudinal direction.

Abstract: A fluid dispenser having a pump mechanism that dispenses a dose of fluid when a movable pump member of the pump mechanism is moved between an extended position and a retracted position. A pump engagement body engages with the movable pump member for effecting movement of the movable pump member. A first cam surface and a second cam surface are connected to the pump engagement body, at least one of the first cam surface and the second cam surface comprising an adjustable cam surface whose location relative to the pump engagement body is selectively adjustable. A camming body engages with the first cam surface and the second cam surface to effect movement of the pump engagement body, and a dose adjustment mechanism allows the location of the adjustable cam surface relative to the pump engagement body to be selected.

Abstract: A handheld fluid meter includes a cartridge valve controlling the flow of fluid through the handheld meter. The cartridge valve includes a valve cartridge and a valve stem disposed within the valve cartridge. The cartridge valve guides the valve stem and provides the only sealing surface for the dynamic seals and control seal disposed on the valve stem. The handheld meter dispenses through a nozzle, which includes an overmolded stem tip that generates a laminar fluid flow as the fluid exits the nozzle. The overmolded stem tip is a compliant material. The handheld fluid meter includes circuitry configured to invert the orientation of a visual output provided by a display of the handheld fluid meter to facilitate installation of the handheld fluid meter for use in an oil bar application.

Abstract: A positive-displacement pump for fluid products, in particular paints, colorants and the like, includes a pump body in which there is formed a pumping chamber, in which a piston is mounted for sliding and is controlled so as to advance and withdraw in order to vary the useful volume of the pumping chamber. The pumping chamber extends in accordance with a longitudinal axis which is inclined, in a non-vertical manner, with respect to a horizontal plane and having an upper region which is positioned at a greater height with respect to a horizontal plane and in the region of which the pumping chamber is placed in communication with at least one intake pipe of a fluid product.

Abstract: An injection device comprises a housing (12) having a longitudinal axis. The injection device further comprises a dose selector (16) capable of setting a dose to be ejected from the injection device and a dose indicator comprising a units wheel (18) operatively connectable to the dose selector so that rotation of the dose selector about the longitudinal axis also rotates the units wheel, and a tens wheel (19) selectively engageable with the units wheel so that rotation of the units wheel also rotates the tens wheel. A biasing means biases the dose indicator axially-rearwardly in the housing. An internal surface of the housing is provided with a tens housing feature selectively engageable with the tens wheel to prevent rotation thereof.

Abstract: A handheld fluid meter includes a cartridge valve controlling the flow of fluid through the handheld meter. The cartridge valve includes a valve cartridge and a valve stem disposed within the valve cartridge. The cartridge valve guides the valve stem and provides the only sealing surface for the dynamic seals and control seal disposed on the valve stem. The handheld meter dispenses through a nozzle, which includes an overmolded stem tip that generates a laminar fluid flow as the fluid exits the nozzle. The overmolded stem tip is a compliant material. The handheld fluid meter includes circuitry configured to invert the orientation of a visual output provided by a display of the handheld fluid meter to facilitate installation of the handheld fluid meter for use in an oil bar application.

Abstract: A method of delivering a glutinous substance to a workpiece from an end-effector comprises using the end-effector to position an applicator relative to the workpiece. The method also comprises urging the glutinous substance from the end-effector through a first channel of a body of the applicator from an inlet of the first channel toward an outlet of the first channel. The method additionally comprises selectively operating an actuator of the applicator to regulate a rate, at which the glutinous substance flows through the first channel of the body of the applicator, responsive to, at least in part, output received from a sensor of the applicator.

Abstract: A metering apparatus including a scale on which a metering head is disposed in such a manner that the scale measures the weight of the metering head, and a metering tool for taking up and dispensing substance, attached to the metering head. The metering tool is configured as a glass tubule having a glass punch slidably disposed therein, forming a seal. The metering head is provided with a first gripping tool for clamping the glass tubule in place and with a second gripping tool for clamping the glass punch in place. The metering head furthermore has a raising and lowering device for raising and lowering the second gripping tool relative to the first gripping tool, such that the glass punch can be raised and lowered in the glass tubule of the metering tool.

Abstract: A device for mixing and dispensing a paste, such as bone cement, comprises a housing (H) with a feeding mechanism (53), and a cylinder (51) for mixing a powder component and a liquid component forming the paste. A piston assembly includes a paste feeding member (57) located in the cylinder, and a tubular member (54). A mixing member (55) is located in the cylinder (51), and a mixing rod (52) extends within the tubular member (54) of the piston assembly. The mixing rod (52) is movable in the tubular member (54) of the piston assembly. The tubular member (54) is provided with external engagement means (T) by which the paste feeding member (57) is movable within the cylinder (51) in a feeding direction. The feeding movement is operated by the feeding mechanism.

Abstract: An apparatus (10) is provided for dispensing a flowable product from a collapsible container (12) comprising an air-tight cavity (14) and an opening (16). The apparatus (10) includes a reservoir (18) comprising a chamber (20) for storing flowable product, the chamber (20) comprising a product inlet (22) for receiving flowable product delivered from the air-tight cavity (14) of a connected collapsible container (12) through the opening (16) thereof, and a product outlet (24) for the flowable product. A piston (46) is positioned inside the chamber (30) and is movable to vary the volume of the chamber (30), for example between a first position defining a maximum chamber volume and a second position defining a minimum chamber volume.

Abstract: An apparatus for inflating an air bag of a protection device. The apparatus includes a canister including a first compartment and a second compartment. The first compartment is adapted to contain a compressed gas. A seal is between the first compartment and the second compartment which is adapted to seal the compressed gas inside the first compartment. The second compartment includes a two-step mechanism configured to break the seal to cause thereby an initial gas flow from the first compartment into the second compartment. The initial gas flow causes a wide opening in place of the seal to be created for rapid gas flow through the second compartment and into the air bag to rapidly expand the air bag.

Abstract: An infusion apparatus for delivering medication includes a housing, a drive mechanism, a force sensor, and a transfer element. The drive mechanism comprises first and second conveying elements, the second conveying element for advancing a plug in a reservoir in the distal direction, the first conveying element with limited axial movement relative to the housing but rotatable to cause an ejecting or resetting movement of the second conveying element. The force sensor is arranged along a central axis between the housing and the proximal end of the drive mechanism. The transfer element is axially arranged between the force sensor and the first conveying element and the force sensor bears axial forces exerted by the ejection movement. The second conveying element moves the transfer element away from the first conveying element against the bias of a restoring force such that the force sensor bears axial forces exerted by the resetting movement.

Abstract: The invention relates to a method for detecting an occlusion in an infusion line (200) during an infusion process comprising the steps of receiving a periodically measured value of a force (F) that is applied by a pumping device (1) to push a liquid through the infusion line (200) and that is indicative of the pressure (P) in the infusion line (200), and subtracting from the measured force value (F) a frictional force component (F0), that is indicative of a true frictional force, for correcting the measured force value (F) by the true frictional force. The method is characterized in that the value of the frictional force component (F0) is periodically updated throughout the infusion process by applying an equation that comprises a term that takes into account the measured force (F).

Abstract: The present invention concerns a drive mechanism for a drug delivery device comprising a housing having a longitudinal axis, a first feedback element which is movable along the longitudinal axis relative to the housing and a second feedback element, wherein the first feedback element and the second feedback element are adapted to interact with each other thereby providing at least one of tactile and audible feedback during at least one of a dose setting and dose dispensing operation of the drive mechanism. Moreover a drug delivery device incorporating such a drive mechanism is disclosed.

Abstract: A fluid dispensing apparatus includes a dispenser body, a valve stem with a valve tip, and a nozzle having a nozzle body defining a fluid chamber terminating in a discharge outlet, an annular valve seat, and a resilient annular portion. A method for dispensing droplets of fluid with the fluid dispensing apparatus includes moving the valve stem relative to the dispenser body and the nozzle body, collecting fluid in the fluid chamber flowing from the dispenser body when the valve stem is moved in an upstream direction with the valve tip out of engagement with the annular valve seat and the resilient annular portion, and dispensing fluid in the fluid chamber out of the discharge outlet when the valve stem is moved in a downstream direction.

Abstract: A solder ball bonding (SBB) tool includes a rotatable feed plate for transporting solder balls from a translatable solder ball reservoir to a nozzle unit, which is a position at which a laser light source can irradiate and thus melt the solder balls. The SBB tool includes a gap between the reservoir and the feed plate positioned over the reservoir, and a feed mechanism coupled with the reservoir, where the feed mechanism is driven by a pressurized gas to translate the reservoir upward across at least a portion of the gap in preparation for movement of a solder ball to the feed plate and downward in preparation for rotation of the feed plate after a solder ball is moved to the feed plate. The gap may have a maximum size that exceeds a nominal size of the solder balls contained in the reservoir.

Abstract: A pipetting module includes a pipette head and a pipette tip. The pipette head has a first coefficient of thermal expansion. The pipette tip includes a connecting portion. The connecting portion is adapted to be sleeved on the pipette head, and the connecting portion has a second coefficient of thermal expansion. The second coefficient of thermal expansion of the connecting portion is greater than the first coefficient of thermal expansion of the pipette head. In addition, an automatic pipetting apparatus is also provided.

Abstract: The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises at least one clicker mechanism (52, 64; 143, 153) for generating a haptic and/or audible feedback during dose selecting, wherein the clicker mechanism (143, 153) generates a different feed-back when selecting single units or multiples of single units.

Abstract: The present invention relates to a display arrangement for an injection device for displaying the size of a dose of a medicament, the display arrangement comprising: a housing (60) providing a rotation axis (3) extending in an axial direction (4), a first display member (22) rotatably supported inside the housing (60) with regard to the rotation axis (3) and having at least one cam (32) radially offset from the rotation axis (3), a second display member (24) rotatably supported inside the housing (60) with regard to the rotation axis (3) and arranged axially adjacent to the first display member (24), a coupling member (26) rotatably engaged with the second display member (24), wherein the coupling member (26) is engaged with the at least one cam (32) of the first display member (22) when the first display member (22) is in a predefined angular position or angular range, wherein the coupling member (26) and the first display member (22) are mutually engaged via a retaining arrangement (48) when the cam (32)

Abstract: An injection device includes a housing and a setting part configured to, in relation to said housing, rotate in a first rotational direction when an amount of injection fluid to be dispensed is being set. The setting part rotates in a second rotational direction counter to the first rotational direction when the injection fluid is pressed out of the injection device. A latching unit defines at least one latching position of the setting part and acts between the setting part and the housing. The latching unit is active at least when the amount of injection fluid to be dispensed is set and each of the latching positions has an unequivocal rotational position of the setting part in relation to the housing assigned thereto.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to a non-numerical display for such a device. The display comprises a housing with at least one window, a dosing element movable relative to the housing during dose setting and/or dose dispensing, and a movable indicator element visible through the at least one window The indicator element is coupled to the dosing element and/or to the housing such that it moves not proportional to the dosing element.

Abstract: A mechanically-actuated vacuum-controlled fluid collection system includes a mechanically-actuated vacuum controller (MA VC) to draw fluid into a chamber through the opening to the chamber. The system may include a releasable seal to seal the opening, and the MAVC may include a spring-loaded plunger to create a vacuum within the chamber when sealed. The system includes multiple fluid chambers, and may further include a single actuator or multiple corresponding actuators. The system may be configured to add a pre-loadable reagent to fluid drawn into the one or more chambers, and may be configured to add the reagent in proportion to a volume of the fluid. The system may be controllable to release collected fluid to another device, such as for assay and/or transport. The system may be configured to draw a liquid biological sample such as urine, and may include a fluid interface to draw fluid from a biological sample container.

Abstract: In some examples, a medical dispensing device includes a housing and a trigger. A first engager of the device is configured to move axially as the trigger pivots. As the first engager moves, it engages a rod. A maximum proximal position of the rod is defined by a stop. A spring presses the first engager into the trigger such that either the trigger or the first engager rests against a stop limiting rotation of the trigger. A second engager moves axially as the trigger pivots. At the actuated position the second engager, defined by a stop, the second engager limits proximal movement of the rod. An assembly transfers movement of the trigger to the second engager after the trigger has pivoted a threshold amount. A member of the assembly distally moves the second engager. Until it is at the actuated position, the second engager enables the rod to proximally move.

Abstract: An exhaust valve assembly for a bottle attachment apparatus for handling liquids has a valve housing which forms a valve chamber having an inlet and an outlet, an exhaust valve body disposed on the inlet in the valve chamber, and a safety valve body disposed on the outlet in the valve chamber. The exhaust valve body is biased toward an exhaust valve seat, counter to the flow direction of the liquid and the safety valve body is biased toward a safety valve seat in the flow direction of the liquid. The safety valve seat is integrally molded on the valve housing.

Abstract: The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge (170) containing a medicament and a last dose protection mechanism for preventing the selection of a dose, which exceeds the amount of medicament left in a cartridge (170). This last dose protection mechanism comprises a first member (60), which is rotatable in a first direction during dose selecting and in the opposite direction during dose dispensing, a second member (50) coupled to the first member (60) and to the housing (10) such that the second member is moved relative to the first member (60) and to the housing (10) upon rotation of the first member (60) and a third member (100) which is moved relative to the first and second member (50, 60) during dose dispensing. Abutment of the second and third member (50, 100) prevents increasing the selected dose.

Abstract: A dispenser for dispensing a liquid onto a substrate is disclosed. The dispenser includes a dispenser module including a nozzle body having an inlet, an outlet, a chamber for receiving a liquid, and a central valve body attached to the nozzle body. The central valve body defines a piston chamber. The dispenser module also includes a valve member having a piston portion disposed within the piston chamber of the central valve body and a needle portion extending form the piston portion into the chamber of the nozzle body. The dispenser also includes a heater block for heating the nozzle body, where the heater block defines a liquid passage for transporting liquid from the liquid supply to the dispenser. A first surface of the heater block directly contacts the nozzle body, and the entirety of the central valve body is spaced from the heater block.

Abstract: An assembly for a drug delivery device includes a dose setting member to be moved by a user from an initial position to a dose sett position and a housing part. The dose setting member and the housing part are connected to form a housing of the assembly. The assembly includes an activation member coupled to the dose setting member to convert a rotation of the dose setting member with respect to the housing into a proximal movement of the activation member with respect to the dose setting member when the dose setting member is moved from the initial position to the dose set position. The activation member has a proximal end section extending from an activation face of the activation member, where in the initial position of the dose setting member, the proximal end section is fully in or slightly protrudes from the proximal end of the housing.

Abstract: The invention relates to a metering device (1) for the metered application of a highly viscous product onto a substrate (2), comprising a housing (3) with an inner side (7) and an outer side (6), a cartridge (10) forming a receiving space (14) for the highly viscous product to be metered, a piston (20) and a spring element (17), wherein at least one engaging element (22) is formed on the inner side (7) of the housing (3) and a row of neighboring engaging recesses (21) is formed on the piston (20), wherein both the engaging element (22) and the engaging recesses (21) are arranged outside of the receiving space (14), and wherein the engaging element (22) engages into an engaging recess (21) on the piston (20) with an actuation of the metering device (1), and wherein, after an actuation of the metering device (1), a returning movement of the housing (3) into the starting position thereof brings about a transition of the engaging element (22) from the engaging recess (21) into a neighboring engaging recess (21).

Abstract: A syringe body is disclosed, wherein the syringe body is configured to withstand pressures within a fluid reservoir of the syringe body of between about 0 atmospheres (atm) and about 81 atm and/or between about 0 atm and about 109 atm. The syringe body may be configured for use in connection with an inflation device. The syringe body may comprise one or more stiffening ribs and/or a stiffening lip. Methods of using the syringe body in connection with an inflation device are also disclosed.

Abstract: A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.

Abstract: Medical devices are described herein. More particularly, the disclosure relates to controlled injection devices, systems, and methods used for the introduction of treatment material into a cavity. An exemplary controlled injection system comprises an injection device and a jig. The jig is adapted to receive the injection device and has a jig head, jig shaft, and a jig housing.

Abstract: A medical device including a brake having a housing member and an actuation member. The housing member has a receiving portion and is configured to be removably coupled to a syringe. The actuation member is movably coupled to the housing member.

Abstract: An applicator (102) for delivering a glutinous substance (168) to a workpiece (170) from an end-effector (101) is disclosed. The applicator (102) comprises a body (110) and a plunger (186). The plunger (186) comprises a gate (118), movable within an outlet portion (182) of a first channel (115) of the body (110) between, inclusively, an open position, allowing the glutinous substance (168) to flow from an inlet (116) of the first channel (115) to an outlet (117) of the first channel (115) and a closed position, preventing the glutinous substance (168) from flowing from the inlet (116) of the first channel (115) to the outlet (117) of the first channel (115). The applicator (102) further comprises an actuator (131), selectively operable to move the plunger (186) such that the gate (118) moves between, inclusively, the open position and the closed position.

Abstract: A medicament delivery device is presented having an elongated housing extending in a longitudinal direction, which housing is arranged to accommodate a medicament container, an end cap arranged with a first attachment element designed to engage with a second attachment element on the housing for attaching the end cap to the housing, a rotator rotatably arranged inside the housing, an activator axially slidable with respect to the housing from an extended position to a retracted position and operably connected to the rotator such as to rotate the rotator from an initial non-activated rotational position and an activated rotational position when the activator is moved from the extended to the retracted position. The rotator further comprises a blocking element arranged to cooperate with the first attachment element for preventing disengagement of the first attachment element from the second attachment element when the rotator is in the activated rotational position.

Abstract: Described herein are syringe extrusion accessories comprising: a handle operatively coupled to an attachment portion configured to attach to a syringe; and at least one pawl operatively coupled to the handle and configured to engage with a plunger of the syringe, wherein the syringe extrusion accessory is configured to transfer a substantially perpendicular force applied to the handle to an axial force to push the plunger and extrude a product from the syringe.

Abstract: A dose control mechanism for a syringe includes an engaging screw thread arrangement between an exterior surface of a plunger and a longitudinally extending channel of a housing. The engaging screw thread arrangement includes at least one thread segment and a pitch guide including a variable pitch thread. At least a portion of the longitudinally extending channel of the housing including one of the pitch guide and the at least one thread segment, and the plunger includes the other of the pitch guide and the at least one thread segment. The plunger resides at least partially within the housing with the at least one thread segment engaged with the pitch guide. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle.

Abstract: A drive member for driving a piston rod in a drug delivery device is provided. The drive member is configured to be driven in a rotational movement by an actuating member. The drive member comprises a track for transmitting a driving load from the actuating member to the drive member. The track comprises both sections running in a distal and sections running in a proximal direction of the drive member. Moreover, a drug delivery device comprising such a drive member is provided.