Abstract: A system and method for substantially eliminating the release of pathogen agents circulating in the air within a collection box. The mail deposit openings (12, 14) of a collection box mail chute (16) are adapted with gaskets (18, 20) to form an airtight seal when the mail chute (16) is opened and closed, thereby isolating the collection box interior (26). An alternative embodiment can further include a charging device (32) and a chargeable material (34) to attract and detain airborne and free pathogen particles that enter the mail chute passage (22) either by newly deposited mail pieces (38) or airborne pathogen particles that migrated from within the collection box collection area (26).