Abstract: The disclosure provides nanoparticles of indirubin and methods of making and using these particles for the treatment of cancer, neurodegenerative disorders and inflammatory diseases. The effective average particle size of the nanoparticles is less than 2000 nm.

Abstract: An adjustable-length tensile member, for example, a strap for a wearable pack, can include a fastener member defining first and second apertures and a cross-member positioned therebetween. A strap can extend through the first aperture in a first direction, over the cross-member and through the second aperture in a direction opposite to the first direction. A cover plate can matingly engage with the fastener member to obscure a segment of the strap from view. Wearable packs can incorporate such adjustable-length tensile members. Methods for assembling such adjustable-length tensile members are also disclosed.

Abstract: A buckle apparatus for use in adjusting a length of a strap coupled to a bag includes a slider buckle having a pair of openings and a loop member coupled to the bottom face of the slider buckle to permit the strap to extend within the loop member and through the pair of openings in the slider buckle, and an anchor buckle having a pair of openings, a pair of loop members coupled to the bottom face of the anchor buckle and at least one clip coupled to the top face of the anchor buckle. The strap extends within the loop members and openings in the anchor buckle. A user can retract an adjusted loop portion above the openings in the slider buckle and secure the loop portion to the at least one clip of the anchor buckle, thereby shortening the strap length.

Abstract: A lightweight, secure, and low profile adjustable locking buckle has a first steel loop which overlies a second steel loop with a rear member spaced from a front member by two side members. The first loop front member has a forward projection which extends frontwardly and is dimensioned to fit within a central opening in the second loop. Each side member of the second loop has a ramped portion, such that the front member is spaced upwardly from the rear member. A fixed strap encircles the rear portions of the first loop and the second loop and is fixed to a supporting element. An adjustable strap extends beneath the first loop front portion and the second loop front portion, turns over the first loop forward projection and beneath the second loop front portion to be releasably secured to itself. Side tabs may be formed on the loops to facilitate adjustment.

Abstract: Devices and techniques for integrating a silicon superlattice optical modulator on a silicon substrate with other circuit elements. The superlattice structure is designed to convert the indirect bandgap structure of silicon into a direct bandgap structure to achieve more efficient optical absorption. The modulator can be fabricated based on a structure of a circuit element by using standard fabrication processes for silicon integrated circuits such as metal oxide semiconductor processing.