Sample Holder Or Supply Patents (Class 250/576)
  • Patent number: 8055471
    Abstract: A method for discriminating particle groups comprises generating, by a particle analyzer, a particle characteristic distribution histogram in which the abscissa indicates respective channels for representing the characteristics of the particles, and the ordinate indicates the particle count; setting a valid area selection height in the particle characteristics distribution histogram; and generating an equivalent negative histogram based on the set height and the particle characteristic distribution histogram.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: November 8, 2011
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Huan Qi, Wenjun Tong
  • Patent number: 8004667
    Abstract: An inspection apparatus for containers, comprising a first illumination device which directs light having first characteristic properties onto the base of the container, a second illumination device which directs light having second characteristic properties, which differ at least partially from the first characteristic properties, onto the base of the container, and at least one image recording device which receives at least a portion of the light directed onto the base of the container and transmitted by the latter. At least the second illumination device illuminates the base of the container in an indirect manner.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: August 23, 2011
    Assignee: Krones AG
    Inventor: Rainer Kwirandt
  • Patent number: 7977660
    Abstract: An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window.
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: July 12, 2011
    Assignee: General Electric Company
    Inventors: Radislav Alexandrovich Potyrailo, Scott Martell Boyette, Glenn Alfred Johnson, William Guy Morris, Ronald James Wroczynski, Andrew Michael Leach, Peter Miller, Caibin Xiao
  • Patent number: 7948625
    Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: May 24, 2011
    Assignee: Helicos Biosciences Corporation
    Inventor: Kevin Ulmer
  • Publication number: 20110114859
    Abstract: A sensor chip includes: a substrate that has a planar portion; and a diffraction grating, on which a target substance is placed, that includes a plurality of first protrusions periodically arranged in a period equal to or greater than 100 nm and equal to or less than 1000 nm in a first direction that is parallel to the planar portion, a plurality of base portions that is located between two of the first protrusions adjacent to each other and configures a base of the substrate, and a plurality of second protrusions that is formed on upper faces of the plurality of the first protrusions, has a surface formed from a metal, and is formed on the planar portion.
    Type: Application
    Filed: November 18, 2010
    Publication date: May 19, 2011
    Applicant: Seiko Epson Corporation
    Inventors: Jun Amako, Kohei Yamada
  • Patent number: 7935948
    Abstract: An apparatus for monitoring a position of a semiconductor process fluid interface in a dispense nozzle includes an extended optical source adapted to provide an optical beam propagating along an optical path. The optical beam is characterized by a path width measured in a first direction aligned with a dispense direction. The apparatus also includes an optical detector coupled to the optical path and adapted to detect at least a portion of the optical beam and a dispense nozzle disposed along the optical path at a location between the extended optical source and the optical detector. The apparatus further includes a nozzle positioning member coupled to the dispense nozzle and adapted to translate the dispense nozzle in the first direction.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: May 3, 2011
    Assignee: Sokudo Co., Ltd.
    Inventors: Erica R. Porras, Natarajan Ramanan
  • Patent number: 7884313
    Abstract: A sensor arrangement includes at least one transparent elevation, which is formed on the surface. The transparent elevation is made of a first transparent material. At least one first facet of the transparent elevation defines a first angle with the surface. This first angle is larger than an angle at which a total-reflection occurs at an interface of the first transparent material and air and is at the same time smaller than an angle at which a total reflection occurs at an interface of the first transparent material and the liquid. A light source is arranged for emitting an incident ray into a first direction passing through the surface into the transparent elevation such that in a presence of a liquid at the first facet, an incident ray is transmitted through the first facet. In an absence of a liquid, the incident ray is reflected due to a total reflection at the facets. A light detector is provided for detecting the reflected ray.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: February 8, 2011
    Assignee: Robert Bosch GmbH
    Inventor: Matthieu Richard
  • Patent number: 7879619
    Abstract: An apparatus for detecting one or more substances includes a radiation source emitting a beam of radiation and also includes a material capable of reflecting the beam of radiation with a first characteristic and capable of reflecting the beam of radiation with a second characteristic when the material interacts with the one or more substances. The apparatus also includes two or more radiation detectors to detect the first and second characteristics of the beam of radiation. A first one of the two or more radiation detectors is adjustably aligned to detect the first and second characteristics of the beam of radiation reflected from a first region of the material. A second one of the two or more radiation detectors is adjustably aligned to detect the first and second characteristics of the beam of radiation reflected from a second region of the material.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: February 1, 2011
    Inventors: Tianwei Jing, Feimeng Zhou, Nongjian Tao
  • Patent number: 7838859
    Abstract: A fluid overfill probe is resistant to failure caused by physical stresses resulting from thermal expansion of probe components. A fluid level detector is connected to circuit components that are mounted on a circuit board located in a housing of the probe. The circuit board is located within a tube that is positioned within, and secured to the housing, and the circuit board is secured to an inner surface of the tube along its edges. The tube has a shape and rigidity sufficient to maintain a gap between the circuit components and the inner surface of the tube such that thermal expansion of probe components result in no physical stress to the circuit components.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: November 23, 2010
    Assignee: Scully Signal Company
    Inventor: Robert R. Trottier
  • Patent number: 7838835
    Abstract: The present invention relates to a sealable cell for measuring a liquid sample comprising a spectroscopic probe and a removable cap that can accommodate at least the head of the probe, wherein the internal wall of the cap comprises one or more grooves which are disposed so as to allow a liquid sample to enter the head of the probe and air to escape from the head of the probe to enable improved spectra to be obtained.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: November 23, 2010
    Assignee: BP Oil International Limted
    Inventor: Alasdair Iain Thomson
  • Patent number: 7820995
    Abstract: The present invention relates to a component for a household appliance, in particular for a dishwasher, and to a sump for a household appliance, in particular for a dishwasher, using it. Both the component and the sump are adapted to detect and/or control the level of a liquid in a tub. The component and/or the sump comprise a light transmitter adapted to generate a light beam, a light receiver adapted to receive the said light beam, and at least one optical element, in particular made of transparent material, adapted to affect the said beam depending on the content of the tub.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: October 26, 2010
    Assignee: Eltek S.p.A.
    Inventors: Costanzo Gadini, Fabio Nebbia
  • Patent number: 7791013
    Abstract: A line scanning arrangement for imaging microarrays includes a line illuminator that converts output from one or more lasers to a radiation line. The laser output passes through a single mode fiber and a module that converts the laser light to the radiation line. The line is confocally directed to sites on the microarray, and retrobeams returned from the sites are collected on an imaging detector. The microarray is moved in the imaging apparatus so as to progressively illuminate an array or matrix of sites for imaging.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: September 7, 2010
    Assignee: Illumina, Inc.
    Inventors: Mark Wang, Wenyi Feng, Robert Kain
  • Patent number: 7777886
    Abstract: Improved optical alignment precision to a passive optical cavity is provided by including a combination of a weak focusing element and a translation plate in the input coupling optics. Adjustment of positions and angles of these optical elements, preferably after all other input optical elements are fixed in place, advantageously provides for high-precision optical alignment to the cavity, without requiring excessively tight fabrication tolerances. Fabrication tolerances are relaxed by making the optical power of the weak focusing element significantly less than the optical power of a strong focusing element in the input optics. The position and angles of the beam with respect to the cavity can be adjusted, as can the size of the beam at the cavity. Differential adjustment of the beam size in two orthogonal directions (e.g., tangential plane and sagittal plane) at the cavity can also be provided.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: August 17, 2010
    Assignee: Picarro, Inc.
    Inventors: Serguei Koulikov, Bruce A. Richman, Dmitri Davydov
  • Publication number: 20100200781
    Abstract: A first integrated circuit operable in association with a microfluidic structure is provided that includes a field generator, a controller configured to control the field generator to generate at least one field to effect movement of at least one analyte of interest in a fluid contained in the microfluidic structure, and an optical detection component configured to optically detect the at least one analyte of interest, as movement of the at least one analyte of interest through the microfluidic structure is effected by the at least one field. A second integrated circuit operable in association with a microfluidic structure is also provided that includes an optical detector configured to generate an output indicative of light from at least one analyte of interest in a fluid within the microfluidic structure; and circuitry configured to convert the output of the optical detector to a digital value.
    Type: Application
    Filed: February 8, 2010
    Publication date: August 12, 2010
    Inventors: Maziyar Khorasani, Duncan Elliott
  • Publication number: 20100182606
    Abstract: An apparatus and method are provided for optically measuring multiple parameters of a test sample at a regulated temperature. The test sample is held in a cuvette within a sample chamber or a fluidic channel on a fluidic chip. The temperature is sensed and modulated within a desired range. Either excitation light is directed through the test sample, and the emitted light is detected by a detector which converts the detected emission light into an output signal; or a probe light is directed to the test sample and at a detector. The output signal is transmitted to the control system which converts the output signal into output data representative of the fluorescence intensity, optical density and/or refractive index of the test sample.
    Type: Application
    Filed: January 15, 2010
    Publication date: July 22, 2010
    Applicant: INNOVISION INC
    Inventors: Elmar Prenner, Kirat Singh
  • Publication number: 20100176304
    Abstract: Optical windows are provided that transmit light such as deep-UV (DUV) light. An exemplary window includes a window substrate that is transmissive to at least one wavelength of the light. The window substrate has an incidence surface decorated with sub-wavelength asperities arranged so as to render the incidence surface solvophobic to the light-transmissive liquid. The arrangement of sub-wavelength asperities can be configured to render the incidence surface super-solvophobic to the liquid. The sub-wavelength asperities can have any of various shapes and combinations thereof, and can be regularly or irregularly arranged.
    Type: Application
    Filed: March 22, 2010
    Publication date: July 15, 2010
    Inventor: Michael R. Sogard
  • Patent number: 7751049
    Abstract: A fluid quality monitoring apparatus (100) comprising a fluid flow channel (120) having a photo sensing material (104) disposed upon a first surface and a light source emitting light (132) through an opposing light transitive surface (106). The condition of the fluid affects the absorption and reflection of the light. The penetrating light is received by the photo sensing material (104), which provides an output that can be utilized to analyze the condition of the fluid. The light can be provided via a plurality of LEDS, the incorporation of a radially distributed series of fiber optic strands, or any other light source. The sensing material can include defraction gratings, improving the monitoring process. The sensing material can be incorporated in a variety of configurations. The apparatus is preferably designed to be integrated between a fluid filter and the respective filter mounting bracket.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: July 6, 2010
    Inventors: William A Jacobs, Allen D Hertz
  • Patent number: 7751050
    Abstract: A fluid quality monitoring apparatus (100) comprising a fluid flow channel (120) having a photo sensing material (104) disposed upon a first surface and a light source emitting light (132) through an opposing light transitive surface (106). The condition of the fluid affects the absorption and reflection of the light. The penetrating light is received by the photo sensing material (104), which provides an output that can be utilized to analyze the condition of the fluid. The light can be provided via a plurality of LEDS, the incorporation of a radially distributed series of fiber optic strands, or any other light source. The sensing material can include defraction gratings, improving the monitoring process. The sensing material can be incorporated in a variety of configurations. The apparatus is preferably designed to be integrated between a fluid filter and the respective filter mounting bracket.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: July 6, 2010
    Inventors: William A. Jacobs, Brian N. Nover, Allen D. Hertz
  • Patent number: 7723711
    Abstract: The invention relates to an optical sensor comprising at least one detection module which comprises an organic light emitting diode (1) and an organic detection photodiode (2, 2a) for measuring emitted light which during the use of the sensor reaches the photodiode via the sample holder. Optionally, a sensor according to the invention further comprises a plastic waveguide.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: May 25, 2010
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzock TNO
    Inventors: Harmannus Franciscus maria Schoo, Jacobus Johannes Frederik Van Veen, Hermanus Hendricus Petrus Theodorus Bekman
  • Patent number: 7705339
    Abstract: The present invention provides core technologies necessary for a portable, low cost LED-based handheld fluorometer. The fluorometer is based on a heater integrated within the walls of the reaction chamber, and an orthogonal geometry LED based light source to provide optical excitation. Power is supplied through either an internal power supply, and data is collected in real-time through standard serial interfaces of personal computers, which can also be used to provide power, or personal digital assistants. Thermal regulation is automatically maintained using temperature sensor feedback control. Such a handheld system can allow applications requiring temperature sensitive photometric measurements for real time analyte detection to be performed in the field.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: April 27, 2010
    Assignee: University of South Florida
    Inventors: Matthew C. Smith, David Fries, George Steimle, Stanislav Ivanov
  • Publication number: 20100072371
    Abstract: Apparatus derives a sample liquid property and has a container with an outlet section having an overflow edge at a horizontal sample surface. A light source above the surface generates a probe light beam at a non-zero angle ?1 to a normal to the surface. A detector above the surface detects intensity of light emitted out through the surface along a first detection axis forming a non-zero angle ?1 with the surface. An optical barrier between the probe light beam and the first detection axis blocks reflected or scattered light. An inlet section receives sample liquid and has an opening to the main section beneath the sample surface. A separating member separates the sample surface of the inlet section from the sample surface of the main section.
    Type: Application
    Filed: December 1, 2009
    Publication date: March 25, 2010
    Applicant: SWAN Analytische Instrument AG
    Inventor: HEINZ WAGNER
  • Patent number: 7663756
    Abstract: Devices and method for photo acoustically detecting a gas are disclosed. In one illustrative embodiment, a gas sensor includes an optical cavity defined by one or more optical segments separating at least two mirrors. A photo acoustic cell, configured to receive a gas from the surrounding environment, is provided at least partially within one or more of the optical segments of the optical cavity. One of the at least two mirrors is configured to couple electromagnetic radiation into the optical cavity and to interact with the gas. A detector is acoustically coupled to the photo acoustic cell to detect absorption of the electromagnetic radiation by the gas.
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: February 16, 2010
    Assignee: Honeywell International Inc
    Inventor: Barrett E. Cole
  • Patent number: 7658884
    Abstract: The apparatus for deriving at least one property like turbidity or fluorescence of a sample liquid from measuring emitted light emitted from said sample liquid upon irradiation of said sample liquid with a probe light beam comprises a container for containing said sample liquid, said sample liquid forming a sample surface. It furthermore comprises a light source for generating said probe light beam directed, in an angle ?1?0° with respect to a sample surface normal, at said sample surface, and a detector adapted to detecting an intensity of said emitted light emitted through said sample surface out of said sample liquid generally along a first detection axis, said first detection axis forming an angle ?1?0° with a sample surface normal.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: February 9, 2010
    Assignee: Swan Analytische Instrumente AG
    Inventor: Heinz Wagner
  • Patent number: 7649189
    Abstract: A cavity ring-down sensor having an optical path of mirrors and an interface proximate to a mirror with a normal incidence optical fiber coupling. The interface may be a block of transmissive materials having different indices of refraction for receiving a light beam of normal incidence from an optical fiber and directing the beam into the optical path. The sensor may be used applications where the optical fiber needs to be straight into the sensor without unusual bending because of space limitations. One application of this sensor may be for ground water testing via a narrow well casing.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: January 19, 2010
    Assignee: Honeywell International Inc.
    Inventor: Barrett E. Cole
  • Publication number: 20090321661
    Abstract: A fluorescent substance having fluorescent pigment molecules, which are enveloped in a light transmitting material that transmits fluorescence generated by the fluorescent pigment molecules, is employed as fluorescent labels in a detecting method the detects the amount of a detection target substance based on the amount of light which is generated due to excitation of the fluorescent labels. The fluorescent substance is excited by evanescent waves which are generated due to leakage from an optical waveguide mode.
    Type: Application
    Filed: June 26, 2009
    Publication date: December 31, 2009
    Applicant: FUJIFILM Corporation
    Inventor: Hisashi Ohtsuka
  • Publication number: 20090321662
    Abstract: A sensor chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection target substance in a sample binds to the sensor-portion when the sample is placed in contact with the sensor-portion. The sensor-portion is irradiated with excitation-light to generate an enhanced electric-field on the sensor-portion. The amount of the detection target substance is detected based on the amount of light generated by excitation of a fluorescent-label in the fluorescent-label binding-substance in the enhanced electric-field.
    Type: Application
    Filed: June 26, 2009
    Publication date: December 31, 2009
    Applicant: FUJIFILM Corporation
    Inventor: Hisashi Ohtsuka
  • Publication number: 20090315960
    Abstract: To implement an ink tank and a printing apparatus that can detect a residual quantity of ink in an ink containing part optically with high accuracy by solving a problem of false detection of an ink residual quantity caused by irregular reflection light and scattered light generated by light from a light emitting part. For that purpose, the light source for emitting light of a first wavelength and the light receiving part for receiving light of a second wavelength are provided. Then the light of the first wavelength from the light source is configured to be irradiated on a luminescent material that is provided in the ink tank and emits the light of the second wavelength using an optical prism only when the ink does not exist in the ink tank.
    Type: Application
    Filed: June 16, 2009
    Publication date: December 24, 2009
    Applicant: CANON KABUSHIKI KAISHA
    Inventor: Masumi Ikeda
  • Publication number: 20090294703
    Abstract: An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.
    Type: Application
    Filed: August 10, 2009
    Publication date: December 3, 2009
    Applicant: Fluidigm Corporation
    Inventors: Marc A. Unger, Geoffrey Richard Facer, Barry Clerkson, Christopher G. Cesar, Neil Switz
  • Publication number: 20090294702
    Abstract: An optical measuring instrument includes: a flow channel for allowing a specimen to be circulated therein; a first light source including a light emitting diode for emitting light to be used for optical adjustment and/or image confirmation in the flow channel; a second light source for irradiating light upon the specimen circulated in the flow channel; and a light detector for detecting the spectrum intensity of the light emitted from the first and second light sources.
    Type: Application
    Filed: May 27, 2009
    Publication date: December 3, 2009
    Applicant: SONY CORPORATION
    Inventors: Shingo Imanishi, Motohiro Furuki
  • Patent number: 7619235
    Abstract: An infra-red liquid sampling cell has a sapphire base plate with a part-spherical concave recess. A sapphire upper plate is hinged relative to the base plate larger radius of curvature than the recess. When the upper plate is lowered into contact with the base plate its convex surface contacts the liquid sample thereby excluding air bubbles and, when in contact with the edge of the recess, produces a well-defined sample thickness. An infra-red source directs radiation down through both plates and the liquid sample to a detector.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 17, 2009
    Assignee: Smiths Group PLC
    Inventors: Mark Julian Gunning, Graham Poulter
  • Publication number: 20090272914
    Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may, for instance, be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The captured and detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection (TIR) methods may benefit from the techniques of the present invention.
    Type: Application
    Filed: May 1, 2009
    Publication date: November 5, 2009
    Applicant: Illumina, Inc.
    Inventors: Wenyi Feng, Jason Bryant, Dale Buermann
  • Patent number: 7611669
    Abstract: The invention provides an assay device for quantification or detection of the presence or absence of an analyte in a liquid sample, comprising a molding (1) permanently or removably attached to a substantially planar plate (2) such that a part of said molding forms a capillary chamber (3) between said plate and the said molding, the device further comprising a chamber (5) into which a test sample and/or reagent can be introduced and further comprising a chamber (7) capable of accommodating an absorbent pad, wherein the said chamber into which a test sample and said chamber capable of holding an absorbent pad are in lateral flow contact via the said capillary chamber (3).
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: November 3, 2009
    Assignee: Imperial College Innovations Ltd.
    Inventors: Andrea Crisanti, Uri Friedlander, Tito Bacarese-Hamilton
  • Publication number: 20090261269
    Abstract: A sensor chip includes a dielectric plate and a sensor portion having a metal layer deposited on a predetermined area on the dielectric plate. A photo-reactable labeling-substance of an amount corresponding to the amount of a substance to be detected in a sample binds to the sensor portion by contacting the sample with the sensor portion. The amount of the substance to be detected is obtained by irradiating the predetermined area with excitation light and by detecting light output from the photo-reactable labeling-substance in an enhanced electric field that has been generated on the metal layer by irradiation with the excitation light. The photo-reactable labeling-substance includes a photo-reactable substance enclosed by a light transmissive material that transmits light output from the photo-reactable substance to prevent metal quenching that occurs when the photo-reactable substance is located close to the metal layer.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 22, 2009
    Applicant: FUJIFILM Corporation
    Inventors: Kazuyoshi HORII, Toshihito Kimura
  • Patent number: 7605389
    Abstract: A particle detector includes an input port for receiving gas and particulate matter. A charging source generating positively and negatively charged species that charges at least some particulate matter in charging region, thereby generating a plurality of charged particles. A trapping region is formed having a potential energy minimum that attracts and confines the plurality of charged particles. A detector detects charged particles in the trapping region.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: October 20, 2009
    Assignee: Verionix, Inc.
    Inventor: Chris Doughty
  • Patent number: 7593109
    Abstract: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical equipment to analyze samples and control the operation thereof.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: September 22, 2009
    Assignee: Helicos BioSciences Corporation
    Inventor: Kevin Ulmer
  • Publication number: 20090230324
    Abstract: The invention provides methods and devices for detecting, identifying, classifying and characterizing particles in a fluid sample. Optical analyzers are provided having a rotating and/or translating sample container for measuring the concentrations of fluorescent particles present in very low concentrations and for characterizing fluorescent particles on the basis of size, shape, diffusion constant and/or composition. Scanning optical analyzers are provided using pattern recognitions data analysis techniques and multichannel detection.
    Type: Application
    Filed: March 31, 2009
    Publication date: September 17, 2009
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Enrico GRATTON, Guido MOTOLESE, Abdel TAHARI
  • Patent number: 7586114
    Abstract: An optical system having a closed loop light path with a source for providing light in a direction parallel to the normal of an input to the light path. The light may be provided via a refracting mechanism to the input. The system may be a cavity ring-down sensor or some other optical device. The light path may be formed in a laser gyroscope type cavity. A light source may have a beam aligned to a spot, indicator or indicator or mark may be determined in accordance with parameters of the refracting mechanism and/or cavity. A fixture for holding the light source may be secured so that placement of the source in the fixture will automatically result in an aligned light source. Then the refracting mechanism may be inserted to further complete fabrication of the optical system.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 8, 2009
    Assignee: Honeywell International Inc.
    Inventors: Barrett E. Cole, James A. Cox, J. David Zook
  • Publication number: 20090206286
    Abstract: The invention relates to a system and method for characterization of a particle flow, for example, for characterization of material for milling, in particular for milled cereals, in a roller frame with a roller passage formed by a pair of rollers whereby the system comprises a withdrawal portion after the roller passage for removal of a milled material sample from the milled material flow exiting the roller passage, a presentation section for conveying and presenting the taken milled material sample, a recording device for recording the milled material passing through the presentation section and an analytical section for analysis of the recorded milled material sample.
    Type: Application
    Filed: July 21, 2005
    Publication date: August 20, 2009
    Inventors: Dario Pierri, Jochen Lisner, André Ruegg, Phillip Geissbuhler
  • Publication number: 20090194707
    Abstract: An optical fiber for use in an immunoassay device having at least one microfluidic channel, the optical fiber being for transmitting excitation light to the microfluidic channel and for transmitting emitted fluorescence to a light detector.
    Type: Application
    Filed: March 7, 2006
    Publication date: August 6, 2009
    Applicant: Nanyang Technological University
    Inventors: Swee Chuan Tjin, Rudi Irawan
  • Publication number: 20090189089
    Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.
    Type: Application
    Filed: April 6, 2009
    Publication date: July 30, 2009
    Inventors: William Bedingham, Peter D. Ludowise, Barry W. Robole
  • Publication number: 20090189088
    Abstract: An apparatus for detecting particles of interest that are dispersed in a fluid mix, which typically includes other particles. The apparatus typically is associated with an interrogation platform arranged to operate in harmony with an opaque member having an orifice sized to promote single-file travel of the particles there-through. A currently preferred embodiment includes a light pipe configured to impinge stimulation-radiation substantially transverse to a direction of fluid flow through the opaque member. Particles of interest may be tagged using antibody-binding, fluorescing molecules. Stimulation radiation from the source causes the tagged particles to undergo a Stokes-shift emission of fluorescence. The resulting fluorescence is detected by the radiation detector and indicates passage of the particles of interest. One workable opaque member is advantageously included in a thin film assembly carried on a removable and disposable card that is adapted for reception in the interrogation platform.
    Type: Application
    Filed: February 19, 2009
    Publication date: July 30, 2009
    Inventors: Harold E. Ayliffe, Curtis S. King
  • Publication number: 20090161108
    Abstract: The present invention concerns a measurement chip (1) for carrying out measurements of transmission and/or emission and/or scattering of light by a fluid sample in an operator unit, wherein the measurement chip has a base plate (2) produced from a transparent polymer material, provided in the base plate (2) are at least one measurement cell (3) for receiving a fluid sample and fluid passages (4, 4) for supplying and discharging fluid to and from the measurement cell (3), and provided in and/or on the base plate (2) outside the measurement cell (3) are mirror surfaces (5) which are so arranged that they direct light emitted from and/or scattered by a fluid sample in the measurement cell (3) from the measurement chip (1), preferably in the direction of a light detector provided in an operator unit.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 25, 2009
    Applicant: Institut fuer Mikrotechnik Mainz GmbH
    Inventors: Ines Frese, Elzbieta Nahrstedt, Klaus-Stefan Drese
  • Patent number: 7521703
    Abstract: In an automatic analyzer which includes a reaction container which contains reaction solution therein, a light source which emit light to be transmitted through the reaction solution, a spectral detector which measures the light transmitted through the reaction solution, a memory which stores light measurement data measured by the spectral detector and a CPU which calculates the light measurement data stored in the memory to obtain a light intensity, wherein the spectral detector measures the light over an entirety of an area from one end to the other end of the reaction container at a portion where the reaction solution reserves, the memory stores the light measurement data measured by the spectral detector, and light measurement data in an area where the reaction solution exists is obtained from the memory to calculate a light intensity.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: April 21, 2009
    Assignee: Hitachi High-Technologies Corp.
    Inventors: Kenichi Nishigaki, Masato Ishizawa, Shigenori Watari
  • Patent number: 7493219
    Abstract: A method for discriminating particle groups comprises generating, by a particle analyzer, a particle characteristic distribution histogram in which the abscissa indicates respective channels for representing the characteristics of the particles, and the ordinate indicates the particle count; setting a valid area selection height in the particle characteristics distribution histogram; and generating an equivalent negative histogram based on the set height and the particle characteristic distribution histogram.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: February 17, 2009
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co.
    Inventors: Huan Qi, Wenjun Tong
  • Publication number: 20090039296
    Abstract: The sensor arrangement comprises at least one transparent elevation, which is formed on the surface. The transparent elevation is made of a first transparent material. At least one first facet of the transparent elevation defines a first angle with the surface. This first angle is larger than an angle at which a total reflection occurs at an interface of the first transparent material and air and is at the same time smaller at an angle at which a total reflection occurs at an interface of the first transparent material and the liquid. A light source is arranged for emitting an incident ray into a first direction passing through the surface into the transparent elevation such that in presence of a liquid at the first facet an incident ray will be transmitted through the first facet, wherein in absence of a liquid the incident ray will be reflected due to a total reflection at the facets. Additionally, a light detector is provided for detecting the reflected ray.
    Type: Application
    Filed: June 28, 2005
    Publication date: February 12, 2009
    Inventor: Matthieu Richard
  • Patent number: 7479197
    Abstract: The invention relates to a process for producing a flow cell for the spectroscopic analysis of samples to be passed through, the process comprising the following steps: (a) provision of a first (10) and of a second (22) window, the second window (22) having at least two sample flow channels (24) for supplying and removing the sample to be analyzed; (b) application of a structured thin layer (18) to one of the windows (10, 22); (c) contacting and liquid-tight securing of the thin layer (18) to the other (22, 10) window, in such a way that facing, plane-parallel window surfaces (14, 20) of the windows (10, 22) and the thin layer (18) delimit a flow chamber (26) which is accessible only through the sample flow channels (24), the windows (10, 22) being optically transparent at least in some regions at least in the region of the flow chamber (26); and (d) filling at least some regions of a filling chamber (28) between the windows (10, 22) which is separated from the flow chamber (26) by the thin layer (18) and ad
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: January 20, 2009
    Assignee: micro-biolytics GmbH
    Inventor: Ralf Masuch
  • Patent number: 7446317
    Abstract: A multi-pass gas cell that operates with reflected radiation pass through a gas, the reflected radiation transmitted and received by first and second fiber optic ports that are subject to an alignment adjustment, and a mirrored viewing window having a inner reflective surface exposed to an interior of the elongated cell body for reflecting the radiation within the cell body, an outer viewing surface, and a transmittance characteristic that permits a portion of the radiation to pass through the mirrored window, from the inner reflective surface to the outer viewing surface, as a visual indicator of the alignment condition of the reflected radiation relative to the first and second fiber-optic ports.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: November 4, 2008
    Assignee: Axiom Analytical, Inc.
    Inventor: Walter M. Doyle
  • Patent number: 7440144
    Abstract: An image input/output apparatus having a scanner unit disposed at an upper stage of an apparatus body and a liquid jet recording unit installed at a lower stage of the apparatus body includes a window which light passes through between the scanner unit and the liquid jet recording unit; an exposure controlling unit configured to control linear irradiation by a light source which illuminates an original platen when a maintenance mode of the recording unit is selected; and a luminous flux irradiation unit configured to irradiate a periphery of a liquid jet recording head in the above liquid jet recording unit with a luminous flux emitted from the light source passing through the window.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: October 21, 2008
    Assignee: Canon Kabushiki Kaisha
    Inventor: Yukuo Yamaguchi
  • Patent number: 7355194
    Abstract: An optical device is described that include: a photoemitter for emitting light, a mounting unit for installing a transparent container accommodating a sample to be subjected to detection, a photoreceptor for receiving the light emitted by a photoemitter and transmitted through the transparent container installed in the mounting unit, a first member disposed between the transparent container and the photoreceptor and having a first pinhole through which passes the light transmitted through the transparent container, and a second member disposed between the first member and the photoreceptor and having a second pinhole through which passes the transmitted light that has passed through the first pinhole.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: April 8, 2008
    Assignee: Sysmex Corporation
    Inventor: Hiroaki Tobimatsu
  • Patent number: RE40768
    Abstract: An apparatus in accordance with the invention is directed to an optical inspection apparatus (10) adapted to inspect a liquid sample. The apparatus includes a tray (20) that is adapted to be physically coupled to a first liquid sample carrier (22) and a second liquid sample carrier (40), each of the first and second liquid sample carriers (22, 40) being adapted to hold a liquid sample. The first liquid sample carrier (22) is of a first type and the second liquid sample carrier (40) is of a second type different from the first type. The apparatus (10) has a light source (108) adapted to illuminate one of the liquid samples associated with one of the liquid sample carriers (22 or 40) when the liquid sample carrier (22 or 40) is coupled to the tray (20) at an inspection location and a detector (110) adapted to receive light from the liquid sample when the liquid sample is being illuminated by the light source (108).
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: June 23, 2009
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Nazeer Shareef