Abstract: A method for producing a cavity valve is provided. The method includes providing a valve body which has a cavity in the interior. The valve body has a circular opening having an opening edge surface on a bottom side. A circular valve cover with a cover edge surface is provided. Inductive heating of at least one of the opening edge surface or the cover edge surface takes place and then welding the valve body to the valve cover by friction welding of the opening edge surface to the cover edge surface.

Abstract: An apparatus for controlling flow through a flow body comprising an intake opening and an output opening in the flow body, a cavity with a first cross-sectional shape and an opening, a diaphragm or a bellows, wherein the diaphragm or the bellows seals the opening of the cavity and the diaphragm or the bellows includes a hole, a plunger with the cross-sectional shape corresponding to the cavity, wherein the plunger is longitudinally movable within the cavity and a plunger portion forms an orifice with cavity portion, and a rod coupled with the plunger for facilitating the longitudinal movement of the plunger, wherein the rod comprises a rod cross section that corresponds to the hole in the diaphragm or the bellows.

Abstract: A dispensing tap has a body which is attached or attachable to a container. The body has a dispensing orifice, and a piston movable within the body between a dispensing position in which flowable product can pass through the orifice and a sealing position in which fluid cannot pass through the orifice. The piston has one or more dispensing apertures through which product can pass when the piston is in the dispensing position to reach the dispensing orifice.

Abstract: A valve diaphragm processed by cold working a small concentric region of one surface has a permanent axisymmetric deformation. The deformed diaphragm can be used in a manner which causes continual elastic compression loading of the diaphragm material. The loading of the deformed diaphragm provides a valve restoring spring force and simultaneously defeats diaphragm tendency toward exhibiting hysteresis. The restoring force provided by the diaphragm can also lessen actuator hysteresis.

Abstract: A fluidic device controls fluid flow in a channel conduit from a fluid entrance to a fluid exit. In some embodiments, the fluidic device comprises the channel conduit, a flexible element, a cross member, and a gate. The channel conduit is bounded by an inner surface that includes a protrusion. The flexible element is coupled to the inner surface of the channel conduit on a different side of the inner surface as the protrusion. The cross member has a first end that is coupled to a deformable surface that is part of the inner surface of the channel conduit and a second end that is coupled to the flexible element. The gate is configured to deform the deformable surface in accordance with a fluid pressure at the gate. An amount of deformation imparted by the gate controls a position of the flexible element via the cross member.

Abstract: Embodiments of the present invention provide an endoscopic fluid control valve. By having just one fluid outlet, the structure of the endoscopic fluid control valve is made simpler with interior space saving. There is no need for a one-way check valve at an operational portion of the endoscope to prevent fluid backflow, and this makes it easy to clean. An embodiment includes valve housing, valve stem, valve core, elastic component, button, first seal, second seal, third seal, fourth seal, gas inlet, fluid inlet and fluid outlet.

Abstract: A method of manufacturing a main valve of a hydrant includes: forming an internal rigid structure including a top surface, a bottom surface, a side surface, and a locating feature, the locating feature defined in a one of the top surface and the bottom surface; positioning the internal rigid structure in a mold by contacting the locating feature with the mold; and forming an outer shell around the internal rigid structure.

Abstract: A hydraulic valve includes a sliding control member that delimits at least one constantly adjustable diaphragm. The sliding control member is configured to be moved in the direction of a longitudinal axis. The hydraulic valve further includes a locking device with a locking member that is configured to be moved counter to the force of a first spring transversely relative to the longitudinal axis. The hydraulic valve further includes at least one catch contour in which the locking member is configured to be engaged in such a positive-locking manner that the sliding control member is releasably retained in a catch position that is associated with the respective catch contour. The position of at least one catch contour is constantly adjustable in such a manner that the free cross-sectional surface-area of the at least one diaphragm is constantly adjustable in the associated catch position.

Abstract: A valve apparatus is equipped with a diaphragm disposed displaceably in the interior of a body, and which opens and closes a fluid passage by separating away from and being seated on a valve seat, a conductive shaft arranged in a through hole that is formed substantially in the center of the diaphragm, and a grounding member for grounding the conductive shaft. Each of the body and the diaphragm is formed from a non-conductive material, and one end surface of the conductive shaft is exposed to the fluid passage.

Abstract: A valve has a valve housing with a first port and a second port, and has a closing member movable along an axial direction. When in a closed position, the closing member interacts sealingly with a valve seat to block a fluid connection between the first and second ports. An fluid-impermeable diaphragm comprises a central opening through which a closing member arrangement including the closing member extends, and a clamping section that runs in a clamping gap. The diaphragm is held with sealing action between the closing member arrangement and a holding arrangement on the housing. The diaphragm has a first section and a second section adjoining the first section. The first section is held in the holding arrangement with a force fit, the second section is guided in the holding arrangement, and the first and second sections are arranged at an angle relative to one another. A form fit is generated by the first section, second section and holding arrangement.

Abstract: A fluid regulator includes an actuator, a body assembly, and a balancing system disposed between the actuator assembly and the body assembly. The actuator assembly includes an upper casing, a lower casing secured to the upper casing, and a diaphragm assembly disposed between the upper and lower casings. The body assembly includes a stem assembly operatively connected to the diaphragm assembly to move with the diaphragm assembly. The balancing system includes a diaphragm operatively connected to the stem assembly to move with the stem assembly. The lower casing of the actuator assembly includes a wall defining a portion of a balancing cavity that receives the balancing system and an inner surface that ends at a shoulder and has an annular groove formed therein that receives a portion of the diaphragm as the fluid regulator moves from a fully open position to a lockup position.

Abstract: A valve mechanism, which constitutes a solenoid valve as one example of a valve, includes a valve plug that is displaced in an axial direction under an excitation action of a solenoid unit, and is equipped with a flexible diaphragm disposed between a valve body and an annular groove formed on an outer circumferential surface of the valve plug. The diaphragm is flexible accompanying displacement of the valve plug and includes first through third projections on an inner edge portion thereof. In addition, the first through third projections are capable of coming into abutment, respectively, against an inner circumferential surface, a first wall surface, and a second wall surface of the annular groove. Further, the inner edge portion is inserted in the interior of the annular groove while being movable slightly in the direction of displacement of the valve plug.

Abstract: A disc for use in a pneumatic valve includes a stiffening insert encased in a flexible body. The stiffening insert acts to protect a central actuation region of the disc against radial compression, which may arise if the disc is used to seal against a bore hole, and against material flow towards the actuation region away from a clamped periphery. The behavior of the disc in a valve assembly is therefore more predictable and reproducible. The flexible body may further be tensioned across the stiffening insert.

Abstract: A membrane valve comprising a first and a second valve housing part and a membrane clamped between the valve housing parts comprises a peripherally surrounding bead on the membrane and a thin, axially movable membrane portion adjacent thereto. The bead is supported by the two valve housing parts and is provided with an undercut at a radial inner side. Further, a membrane for installation in a membrane valve is provided.

Abstract: An actuator for operating a linear valve, such as a gate valve, includes a sealing plate that extends across the diameter of a housing. A diaphragm is located on, and fully supported by, the plate. When pressure media urges the diaphragm and sealing plate downward, the sealing plate urges a step downward to actuate a valve. A hub and an annular support plate can be assembled to form the plate, and the plate can be different sizes by selecting different sized annular support plates.

Abstract: A diaphragm (20) for a diaphragm valve is described. The diaphragm (20) has a body (22) comprising a first elastomer and a resistant layer (24) comprising a second elastomer having a different composition or formulation. Diaphragms described in examples have good flexibility with a high level of chemical resistance and low surface adhesion. A fixing attachment for fixing the diaphragm in the valve is also described.

Abstract: A device in a valve (1) includes a valve housing (2) with at least a first (3) and a second (4) fluid port. A closure element (5) including a sealing portion (15) and diaphragm (30) is arranged in the valve housing (2). The sealing portion (15) is movable between an open position and a closed position. The closure element (5) and valve housing (2) form a flow passage (11) which communicates with the fluid ports when the sealing portion (15) leaves the closed position. A second sealing portion (14) is arranged in contact with a support portion (25) of the valve housing (2). An abutment element (16) is arranged in contact with the second sealing portion (14). The abutment element (16) transmits a force via the second sealing portion (14) toward the support portion (25) to provide a seal. The force is at least partly exerted by a spring element.

Abstract: An implantable device controls the movement of fluid to an inflatable portion of a gastric band. The implantable device includes a body. The body has an inlet, an outlet and a valve seat positioned between the inlet and the outlet. The body defines a fluid passage from the inlet to the outlet. The implantable device also includes a diaphragm. The diaphragm has one or more edges coupled to the body. The diaphragm is made of an elastomeric material and capable of being moved between a closed position that blocks the valve seat and does not allow the fluid to move from the inlet to the outlet and an open position that does not block the valve seat and allows the fluid to move from the inlet to the outlet.

Abstract: Plungers and plunger assemblies for a diaphragm-sealed valve are provided. Each plunger is adapted to be received in a passage of the valve body and includes a base member and an upper member having a transversal play in this passage with respect to the base member. A resilient middle element is provided between the upper and base member. The base member is connected to a plunger actuating mechanism within the valve body. The upper member may therefore be self-aligning within the passage.

Abstract: A cam control valve includes a valve casing having a fluid passage and valve seat, a valve disc seated on the valve seat to open and close the fluid passage, a valve stem holding down the valve disc so it contacts the valve seat, a cam acting on the valve stem to hold it down, a motor rotating the cam, a motor holder holding the motor, a supporting frame fixed to the valve casing and supporting the motor holder so it moves vertically, an elastic member biasing the motor holder towards spacing from an upper side portion of the supporting frame, and height adjustable screws suspending the motor holder from the supporting frame, and adjusting a height of the motor holder with respect to the supporting frame, wherein the height adjustable screws are slidably inserted into the upper side portion of the supporting frame and screwed into the motor holder.

Abstract: An aseptic valve or sanitary valve employs a floating plug situated within a cylindrical valve housing. The floating valve plug has a head that seats against an inlet opening, and has a stem and a generally conic foot that rests upon a diaphragm formed of a flexible, food-grade membrane. An actuator below the diaphragm urges the plug up to lodge against the inlet opening, and relieves force on the membrane and plug to open the valve. Spacer arms radiate from the stem or head of the plug, to keep the plug centered in the housing.

Abstract: Diaphragm valve with internal leak detection and improved external leak sealing performance. In diaphragm valves comprising diaphragms that have shields and backings, a rigid seal plate interposed between the shield and backing prevents peripheral regions of the shield from cold-flowing into the backing, despite the compression forces produced by tightening the fasteners that secure the diaphragm to the valve's bonnet assembly and body. An access port passing through the seal plate provides an interface between a void located between the shield and the backing and a breach detector. The breach detector is configured to detect pressure, volume, moisture or mass deviations in fluid disposed in the void, and the deviations indicate whether there's a rupture in the shield or the backing. The breach detector can be connected to an alarming device or signaling system to provide warnings and alerts to valve operators, process control panels or data communication networks.

Abstract: A diaphragm valve is disclosed. The diaphragm valve includes a valve body including a housing defining a fluid flow passageway and a valve seat. A bonnet assembly including a housing is mounted to the valve body. A diaphragm, a backing cushion and a resilient member are positioned between the bonnet assembly and the valve body. The resilient member is sandwiched between the housing of the bonnet assembly and the backing cushion for urging the backing cushion toward the diaphragm, thereby urging the diaphragm against the valve body.

Abstract: A ball valve and a valve shaft are in a valve chamber. The ball valve opens and closes a valve port. A coil spring arranged in a spring chamber pushes the valve shaft against a diaphragm via a spring bracket of the valve shaft. A cone portion and a flat portion (or a concave portion) inside the cone portion are on the diaphragm. A diaphragm-side end face of the valve shaft is larger in diameter than the flat portion of the diaphragm. When the diaphragm is initially deformed, a boundary portion interposed between the cone portion and the flat portion abuts on the diaphragm-side end face.

Abstract: Apparatus, including a diaphragm valve, is provided featuring a valve body configured with at least one spherically-shaped valve body sealing surface and a diaphragm configured with at least one diaphragm sealing surface, and also configured to respond to an applied force and provide sealing contact between the at least one diaphragm sealing surface and the at least one spherically-shaped valve body sealing surface. The valve body is configured with a spherical weir having a spherical weir sealing surface configured with polish marks substantially perpendicular to a weir leak path. The valve body also has a circular rim having a spherically-shaped peripheral sealing surface configured with polish marks, many of which are substantially perpendicular to a shell leak path.

Abstract: A solenoid comprises at least one armature supported in an armature space. The armature space is encircled by a coil carrying a number of windings which can be loaded with current. The magnetic field generated by it moves the armature against the core. The armature acts on a pin. The armature has on its front seen in the direction of movement a recess in which a structural part is set. The pin is supported on the structural part.

Abstract: An aseptic valve or sanitary valve employs a floating plug situated within a cylindrical valve housing. The floating valve plug has a head that seats against an inlet opening, and has a stem and a generally conic foot that rests upon a diaphragm formed of a flexible, food-grade membrane. An actuator below the diaphragm urges the plug up to lodge against the inlet opening, and relieves force on the membrane and plug to open the valve. Spacer arms radiate from the stem or head of the plug, to keep the plug centered in the housing.

Abstract: A valve having two opposing self-sealing poppets includes a valve body, two poppets, a diaphragm and two levers. The valve body has two passages opposite to each other and two poppet seats disposed opposite to each other and corresponding to the passages. When the valve is in a closed state, both poppets are pressed against the poppet seats and the media is prevented from flowing in either direction. When the valve is in an open state, both poppets axially move away from the poppet seats and the media can flow in either direction.

Abstract: The invention relates to a valve for separating product media in pipes of a product-carrying system. The valve comprises a valve housing and a valve body arranged in a valve housing interior. The valve has a drive element which is movable in the axial direction, is connected to the valve body and is intended for moving the valve body. The valve further comprises a sealing diaphragm for sealing a valve housing interior on the drive side. The sealing diaphragm has a radially extending diaphragm body with a radially inner opening through which the drive element reaches. The diaphragm body has a radially outer edge region and a radially inner edge region which surrounds the radially inner opening. The radially outer edge region is clamped radially and the radially inner edge region is clamped axially. The sealing diaphragm is manufactured from a dimensionally stable material which is thermally resistant up to at least approximately 130° C.

Abstract: A valve having a membrane for controlling flow through the valve, the membrane having open and closed positions. An element urges the membrane to the closed position, and a vacuum pressure at one end of the valve may overcome the urging of the element, thereby moving the membrane to the open position. An actuator is provided for easing or initiating the movement of the membrane. In some embodiments, the valve may take the form of a valve assembly for use in a variety of applications, for example, a valve assembly for relieving a vacuum pressure wherein the assembly includes intake and exhaust ends, a membrane for controlling flow through the assembly, a spring providing a closing bias to the membrane that the vacuum pressure may overcome to move the membrane, and an actuator for initiating the movement of the membrane.

Abstract: The invention provides a vacuum control valve configured to control the vacuum pressure in the vacuum chamber. The vacuum control valve includes a control valve main body, an operation unit, a cylinder, a biasing unit, and a bellofram. The operation unit and the cylinder include a valve opening manipulation chamber and a shutoff load generation chamber. The shutoff load generation chamber is configured to have a common axial center line with the valve opening manipulation chamber and to generate a load applied to the operation unit in a direction for reducing the lift in accordance with a supply of the working fluid. And the shutoff load generation chamber may be formed in an interior of the rod.

Abstract: Provided are a diaphragm, a diaphragm valve, and a method of manufacturing a diaphragm capable of increasing a flow rate (Cv value) of gas without degrading long-term durability even when a displacement amount is increased. A diaphragm (1) has an outer diameter ? of 10 to 35 mm and includes a dome portion (1D) in a dome shape and a flange portion (1T) formed continuously at a peripheral edge of the dome portion (1D) via a boundary portion (1K), the boundary portion (1K) has a radius of curvature R of 0.6 mm or more on a convex side of the dome portion (1D), and the diaphragm is formed of a cobalt-based super-alloy.

Abstract: A fluid injection valve having an inlet which is set up to receive fluid from a supply line and is connected to a chamber, a fluid outlet which is connected to the chamber, is set up to allow fluid to flow out of the fluid injection valve and has a valve arrangement having a valve seat and a valve element, wherein the valve element is set up to perform opening and closing movements relative to the valve seat, a linear actuator which is set up to move the valve element relative to the valve seat, and a spring arrangement which exerts on the valve element a force which is dependent on the fluid pressure prevailing in the chamber.

Abstract: A fluid regulating device comprises an actuator with upper and lower housing components. The upper and lower housing components are secured together at mating flanges via a plurality of fasteners. The upper housing component is formed with a vent to contain a relief valve, which exhausts fluid to the atmosphere under overpressure conditions. The upper housing component is constructed such that it does not require a pedestal or fins extending between the vent and the flange, which advantageously provides a completely unobstructed, continuous, ring-shaped flange for receiving and manipulating the fasteners during assembly and/or maintenance of the regulating device.

Abstract: A tap with a dosing chamber for dosing liquids, in particular for dosing high and medium density liquids, including a body equipped with a connecting part to a container of liquid to be delivered through a liquid delivering passage and a valve that opens and closes the liquid delivering passage with an elastic button that actuates the valve and an air circulating tank in order to vent the liquid container when liquid is dispensed.

Abstract: A control system for a purge valve that can be actuated by low pressure, which can be used for a low pressure or vacuum waste water system, encompassing a first valve and a second valve. The purge valve can be actuated as a function of its position, and the accumulated waste water can be drawn off via the sewage system.

Abstract: A pressure-reducing valve is provided in which a diaphragm rod connected to a valve body of a valve mechanism is connected to a central part of a diaphragm having its peripheral edge part clamped between a body and a diaphragm cover, wherein the diaphragm (28) is formed from a disk-shaped rubber sheet for which the sheet thickness of at least its peripheral edge part is uniform in the natural state, and in a state in which the diaphragm cover (17) is fixed to the body (16) so that the peripheral edge part of the diaphragm (28) is compressively held between a collar portion (17b) of the diaphragm cover (17) and a clamping face (91) of the body (16), a portion having, of the gap between the collar portion (17b) and the clamping face (91), a minimum gap is positioned further inward in the radial direction of the diaphragm (28) than a portion having a maximum gap.

Abstract: A single chamber two-way servo-operated valve includes: a valve body presenting an inlet aperture, an outlet aperture, and an access; a cover to close the access of the valve body; a port dividing the valve body interior into an inlet section and an outlet section; a valving element including a disc for closing the port; and an actuating chamber at least partially defined by the cover. The disc and a flexible diaphragm are connected to the valving element. The disc of the valving element includes a rigid central core which is at least partially covered by a rubber layer adhering to the central core. The rubber layer extends from the edge of the disc to form the flexible diaphragm.

Abstract: The disclosure relates to a valve comprising a body defining at least an admission duct and an outlet duct for a fluid and receiving a valve member that is movable by means of an actuator member fastened to the body to move between a closed position closing the outlet duct and an open position leaving it open, the valve member having a central portion secured to a central portion of a substantially plane diaphragm that has a peripheral portion associated in leaktight manner with a support element secured to the body in such a manner as to co-operate with the support element to define a chamber, the valve member and the diaphragm being pierced by an opening providing permanent communication between the chamber and the outlet duct, the diaphragm being elastically deformable and being dimensioned to urge the valve member into its closed position.

Abstract: A valve for pressurized or liquefied gas comprises a valve body (12) with a gas flow channel (16) and in this channel a sealing seat (30) for an open/close element (32) having a free end (60) where a shoulder (62) is provided. An annular seal (64) is mounted on the free end (60) of the open/close element (32), the annular seal (64) having a front end face (66) facing the sealing seat (30) and a rear end face (68) resting on the shoulder (62) of the open/close body. A holding ring (70) surrounds the annular seal (64) circumferentially and comprises a radial lip (72) that bears on the outer edge of the front end face (66) of said annular seal (64). The annular seal (64) includes an outer annular shoulder (74) on the edge of its front end face and the radial lip (72) with the holding ring (70) has an annular bead (76) facing this outer annular shoulder (74) of the annular seal (64).

Abstract: An object is to provide a flow control valve that is capable of reducing or eliminating backlash generated between a male threaded portion and a female threaded portion engaged with the male threaded portion and preventing or eliminating hysteresis in the flow level. The flow control valve includes a body having a fluid inlet and a fluid outlet, a cover attachable to the body, a motor disposed in a space defined by the body and the cover, a valving element connected to a rotary shaft of the motor with a screw member, and an urging member that urges the valving element toward the motor side or toward the side opposite to the motor.

Abstract: A cover-equipped manual valve having a ratchet mechanism for preventing rotation of a knob, comprising: a rod formed with an external thread portion on an outer periphery thereof, the rod being unconnected to the knob and held against rotation; a sliding nut of a cylindrical shape, the sliding nut being rotatably held by a body and internally formed with an internal thread portion threadedly engaged with the external thread portion of the rod; an engagement member fixed to the knob, the engagement member being elastically deformable to be engaged with the sliding nut and to be disengaged from the sliding nut when larger torque than a predetermined value is applied to the engagement member; and a knob cover of a hollow shape for covering the knob.

Abstract: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e. Polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene.

Abstract: A direct touch type metal diaphragm valve, wherein durability of the valve, that is to say, the ensured number of continuous open/close operations of the valve, is substantially increased under conditions that an appropriate flow rate coefficient Cv is maintained, and changes of the afore-mentioned Cv value over time are mitigated by means of restricting the deformation of the valve seat over time. The afore-mentioned metal diaphragm is formed in a round, reverse-dish shape by laminating a plural number of thin stainless steel plates and a thin Nickel.Cobalt alloy plate, and its center part is bulged upward, and the maximum valve stroke of the valve is regulated to be 55% to 70% of the distance of the maximum bulge height ?h of the afore-mentioned metal diaphragm.

Abstract: A gas regulator includes an actuator, a valve, and a cartridge disposed within the valve to advantageously direct, or “boost,” fluid downstream and away from the actuator under normal operating conditions, thereby increasing the operating efficiency of the regulator. The cartridge includes a first portion with a first diameter and a second portion with a second diameter that is greater than the first diameter. During normal operation, the first portion receives a valve disc of the actuator within generally tight tolerances such that the valve disc and the cartridge restrict fluid communication between the valve and the actuator. This directs or “boosts” the gas toward the outlet of the valve. Additionally, during a relief operation, the second portion of the cartridge receives the valve disc to allow the free flow of gas to the actuator.

Abstract: A high pressure diaphragm gas valve comprises a removable seat assembly (32), including a mounting ring (34) and a synthetic seat ring (36), which is fitted in a central seat hole of a mounting ring (34). A nozzle (60) penetrates in a sealed way into a central through hole (38) of the synthetic seat ring (36). A first gas port (28) is arranged in a front face (62) of the nozzle (60). A second gas port is formed by a gas collecting ring channel (30) incorporated into the valve body (12), wherein it surrounds a nozzle shoulder surface (64) of the nozzle (60) and is itself surrounded by an outer shoulder surface (102) of the valve body (12). The mounting ring (34) is supported with an inner ring flange (82) on the nozzle shoulder surface (64) and with an outer ring flange (84) on the outer shoulder surface (102), so that peripheral gas passages (86) open into the ring channel (30).

Abstract: Diaphragm valve with internal leak detection and improved external leak sealing performance. In diaphragm valves comprising diaphragms that have shields and backings, a rigid seal plate interposed between the shield and backing prevents peripheral regions of the shield from cold-flowing into the backing, despite the compression forces produced by tightening the fasteners that secure the diaphragm to the valve's bonnet assembly and body. An access port passing through the seal plate provides an interface between a void located between the shield and the backing and a breach detector. The breach detector is configured to detect pressure, volume, moisture or mass deviations in fluid disposed in the void, and the deviations indicate whether there's a rupture in the shield or the backing. The breach detector can be connected to an alarming device or signaling system to provide warnings and alerts to valve operators, process control panels or data communication networks.

Abstract: A flow amount adjusting valve includes a handle that enables an opening/closing amount of a valve plug to be adjusted. A piston connected to the valve plug is screw-engaged with a first axial portion of the handle. Additionally, along with displacement of the valve plug in the axial direction via the piston under a rotating action of the handle, an indicator element is accommodated in an interior portion of the handle. A first indicator undergoes screw-engagement with respect to the handle, and the indicator element is displaced together with displacement of the valve plug, such that displacement of the valve plug can be confirmed visually from outside the flow amount adjusting valve.

Abstract: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene.

Abstract: An aseptic diaphragm valve in which a valve seat (37) is formed by a groove including a concave surface of engagement that positioned along an outer diameter of an upper end of an inlet tube (32), and a resilient valve member portion (41) that is annular in extent with a convex surface that moves into the groove to contact the concave surface (37) around the outer diameter of the inlet tube (32) to close the valve. The valve member portion (41) has at least a coating of polytetrafluoroethylene (47) or equivalent material.