Abstract: Provided is a highly sensitive high throughput mass spectrometry-based quantitative assay for 4E/4E regulon pathway proteins has been developed which provides for single sample multiplexed analysis, as well as the analysis of protein phosphorylation states. It may be adapted for use as the first single sample analytical method of the 4E/4E regulon biological pathway.

Abstract: The present invention provides for a method of characterizing and classifying a sample containing a complex molecule, such as a peptide or polypeptide mixture, protein, protein mixture, biologic and biosimilar by using physical analysis, such as mass spectrometry, and statistic methods.

Abstract: Provided is a highly sensitive high throughput mass spectrometry-based quantitative assay for 4E/4E regulon pathway proteins has been developed which provides for single sample multiplexed analysis, as well as the analysis of protein phosphorylation states. It may be adapted for use as the first single sample analytical method of the 4E/4E regulon biological pathway.

Abstract: Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS). Then, three differential biomarkers, including HNP-1, -2 and -3, are identified (P<0.001) and overexpressed in gastric cancer. At last, western blotting and immunohistochemistry are used to validate the protein expression in gastric cancer tissues. In conclusion, the use of the up-regulated proteins, HNP1-3, helps diagnosis and therapy in clinical for gastric cancer after validating the sensitivity and specificity.

Abstract: The present invention provides for a method of characterizing and classifying a sample of peptide or polypeptide mixtures or a biomolecule comprising a polypeptide component by using mass spectrometry and statistic methods for analyzing the mass spectrometry results.

Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Abstract: A compact fluorescent lamp includes a discharge tube such as a spiral discharge tube having a wall forming a discharge chamber between cathodes at first and second ends thereof. At least one auxiliary amalgam assembly is disposed in the discharge chamber at an intermediate region disposed between the first and second ends. The auxiliary amalgam assembly is secured at a location spaced from the inner wall of the discharge chamber.

Abstract: A fluorescent lamp includes a discharge tube having an inner wall forming a discharge chamber. One or more coiled electrodes are disposed within the discharge tube. A mercury containing composition is disposed on at least one coiled electrode.

Abstract: A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

Abstract: The present invention relates to a mercury dispensing system (11; 21, 31) for fluorescent lamps, comprising a dispensing member (12; 22, 32) containing a mercury releasing compound. The dispensing member (12; 22, 32) is fixed on a metal support (13; 23; 33) suitable to be heated by electromagnetic induction in order to cause the activation of said mercury releasing compound. The surface area of the metal support (13; 23; 33) is comprised between 9 and 64 mm2. The invention also relates to fluorescent lamps comprising said mercury dispensing system (11; 21; 31).

Abstract: An amalgam capsule (16) for a low-pressure mercury vapor discharge lamp (1) has a closed end and an opposing end with an opening (21) to allow passage of mercury vapor between the amalgam plug (18) and the discharge space (3) of the lamp (1). A glass rod (19) placed in the capsule (16) restrains movement of the amalgam plug (18), and projections (20) in the inner wall of the capsule (16) restrain movement of the glass rod (19). The presence of the amalgam capsule (16) in the discharge space (3) enables highly-loaded, substantially temperature-independent operation of linear fluorescent lamps such as T8 lamps.

Abstract: The present invention provides for various processes for determining enzyme activity. In one embodiment, a process for detecting an enzyme activity includes contacting a blood component with a substrate comprising a cleavage site of the enzyme and a tag moiety to produce a sample comprising a cleavage product having a known mass, and placing the sample in contact with a SELDI sample chip which has surface moieties which bind to the cleavage product. In another embodiment, the process further includes subjecting the SELDI sample chip to SELDI mass spectrometry to identify the cleavage product. The present invention also provides for a kit which includes a SELDI sample chip having surface moieties capable of binding to an enzyme cleavage product.

Abstract: Embodiments of the present invention relate to the determination of analyte characteristics based upon binding properties using mass analysis and differential labeling reagents.

Abstract: A rapid and efficient method for novel biological substance screening by surface analysis has been developed using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). This method relies on the surface screening of an array of micro-organisms grown on porous membranes, which had previously been in contact with a solid growth medium. ToF-SIMS analysis differentiates among organisms producing different substances, either directly as molecular product, or indirectly through the use of multivariate statistical data reduction techniques. This method has many advantages over traditional microbial screening methods, which require sample preparation and time for assay development.

Abstract: The present invention relates to a method of peptide sequencing by MALDI (matrix-assisted laser desorption ionization) tandem mass spectrometry, which comprises the steps of chemically modifying a sample peptide with at least one chemical modification method selected from the group consisting of guanidination and esterification in order to change the ionization status of the peptide and performing mass spectrometry using a MALDI tandem mass spectrometer and programmed MALDI tandem mass spectrometry. The peptide sequencing method of the present invention is advantageous in that detection sensitivity of the peptide improves significantly and various daughter ions are detected uniformly, thereby enabling perfect de novo sequencing with tandem mass spectrometry only, without database search.

Abstract: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

Abstract: An arrangement of a low-pressure mercury amalgam lamp includes an amalgam deposit and a cladding tube surrounding a lamp, wherein the lamp has a mechanical contact to the cladding tube in a region of the amalgam deposit. A ring-shaped band contacting and surrounding the lamp in the region of the amalgam deposit represents the mechanical contact to the cladding tube.

Abstract: The present invention relates to a method for phosphorylation site-specific labeling of phosphoproteome with a site-specific tagging reagent and analyzing of the resulting labeled one, more especially, a method for in-situ tagging of phosphorylation sites of phosphoproteins retained in polymeric gel with a nucleophilic tagging reagent. It also relates a method for generating new proteolytic cleavable sites at formerly phosphorylation sites by a proper choice of a nucleophilic tagging reagent. It also relates to a method for phosphopeptides analysis and phosphorylation site identification by in-gel digestion of the previously in-gel tagged proteins and subsequent mass analysis of the resulting peptides. The invention provides in-gel chemical tagging method for phosphoaminoacid residue of phosphoproteins retained in polymeric gel matrix. Phosphoprotein can be immobilized into gel matrix by a variety of methods such as gel electrophoresis.

Abstract: The invention relates to methods of manufacturing gas-discharge electron lamps, and neon tubes in particular. According to the invention, it is proposed, prior to carrying out vacuum treatment of the internal space of an electron lamp (1), to mount at least one of said glass capsules (2) in exhaust tube (5), in close proximity to an exposed electrode in such manner that the opening provided in metal container (4) is facing the working area of the lamp (1).

Abstract: A germicidal lamp having amalgam for controlling mercury vapor pressure contained in a location facilitating efficient high output operation. A low pressure mercury vapor discharge lamp has an amalgam container containing an amalgam positioned behind an electrode out of the arc path or space. The amalgam position is retained during high wall loading of the lamp preventing the amalgam from moving out of position. Efficient operation with high current loads and resulting high wall loading and temperatures is possible. The germicidal lamp is particularly suited to being positioned vertically in a waste water treatment system.

Abstract: A light source with a heatable filament (1) or an electrode, with the filament or the electrode being arranged in a bulb (2) or in a tube, is provided with an improved service life by the provision of a depot (3) with at least one chemical element that is also present in the filament or the electrode, and which is associated with the filament or the electrode such that the element is supplied to the filament or the electrode. Furthermore, a method is described for regenerating a light source with a heatable filament (1) or an electrode, with the filament or the electrode being arranged in a bulb (2) or in a tube. By the method, the depot (3) is associated in a first step to the filament or the electrode, with the depot comprising at least one chemical element that is also present in the filament or the electrode. Finally, the element is supplied to the filament or the electrode.

Abstract: A fluorescent lamp containing zinc amalgam and a method of precisely controlling the amount of mercury introduced into a temperature controlled fluorescent lamp. Precise quantities of mercury may be introduced into a fluorescent lamp in the form of solid zinc amalgam pellets that are in a metastable, non-equilibrium state.

Abstract: Cesium dispensers are produced based on the use of a mixture of at least one reducing agent and at least one cesium compound selected among molybdate, tungstate, niobate, tantalate, silicate and zirconate. The cesium dispensers are useful in the production of OLED-type screens.

Abstract: A low-pressure mercury vapor discharge lamp is provided with a discharge vessel (10). The discharge vessel comprises tubular end portions (11; 11′), which each have a longitudinal axis (12; 12′). The discharge vessel (10) encloses a discharge space (18) containing a filling of mercury and an inert gas in a gastight manner. Electrodes (20; 20′) are arranged in the discharge space (18). An auxiliary amalgam is provided on a carrier (25; 25′) in the proximity of the electrodes (20; 20′). According to the invention, a part of the carrier (25; 25′) is arranged in a plane transverse to the longitudinal axis (12; 12′). Preferably, a stem (21; 21′) in the tubular end portion (11; 11′) carries, apart from the electrode (20; 20′), a support in the form of a wire (23; 23′) or an extended exhaust tube, which support carries the carrier (25; 25′). In an alternative embodiment, the carrier is clamped directly onto the stem.

Abstract: The invention relates to a method of adjusting a desired spectrum of light emitted by a gas discharge lamp during its operation, said gas discharge lamp comprising a first ionizable substance and a second substance which is less readily ionizable than the first substance. According to the invention, the gas discharge lamp is operated such that gases of both substances cans be excited, while the partial pressure of the first substance is adjusted in dependence on the desired spectrum. For this purpose, for example, the current through the lamp may be modulated. In an alternative embodiment, this is suitably achieved in that the partial mercury pressure is varied, for example through an adjustment of the temperature of a mercury amalgam present in the gas discharge lamp. The invention also relates to a gas discharge lamp whose color can be varied during its operation, and to a luminaire provided with a supply for such a lamp.

Abstract: A fluorescent lamp has an amalgam container settled inside an exhaust pipe extending from an end portion of a bulb to which electrodes are attached at both end portions. The amalgam container contains amalgam inside and has an opening portion through which the contained amalgam cannot go out and a part for determining the position of the amalgam, wherein the opening portion is located on the side where the exhaust pipe is cut and sealed. This configuration makes it possible to prevent the amalgam from outflowing into an exhaust equipment. In addition, the mercury vapor pressure is maintained optimally, and high luminous efficiency is obtained.

Abstract: A small fluorescent discharge tube and a bulb-shaped fluorescent lamp using the same with improved rise characteristics with respect to luminous flux in the case of a relatively short non-operation time of one to six hours after a stop of operation are provided. The fluorescent discharge tube includes at least three U-shaped glass tubes joined to form one body, electrodes provided at the ends thereof, and one discharge path formed therein. The fluorescent discharge tube further includes first auxiliary amalgams in vicinities of the electrodes, main amalgams placed at least in two locations in the discharge path between the electrodes, and a second auxiliary amalgam placed at least in one location between the main amalgams.

Abstract: An apparatus and method for improving the performance of a lamp includes an envelope (10) enclosing an amalgam or dose (24) of mercury housed in a container (20). The container maintains mercury vapor equilibrium during lamp operation and prevents mercury diffusion during lamp off periods. The container has an opening (24) therein selectively adjustable between an open position and a closed position. A bimetal member (30) is associated with the opening of the container and provides the actuating means by which the container opens and closes. A stopping member (32), such as a valve or ball bearing, is attached to the bimetal member and extends into the container. When the lamp is in operation, the bimetal member is heated causing it to deflect. The deflection moves the stopping member from the container opening and enables the amalgam to maintain mercury vapor pressure equilibrium.

Abstract: A fluorescent lamp containing zinc amalgam and a method of precisely controlling the amount of mercury introduced into a temperature controlled fluorescent lamp. Precise quantities of mercury may be introduced into a fluorescent lamp in the form of solid zinc amalgam pellets that are in a metastable, non-equilibrium state.

Abstract: A glass extension (24) with a cavity (32) for an amalgam (22) is added to an exhaust tube (12) or a flare (14) of a fluorescent lamp. The mouth (36) of the cavity (32) is provided with a bimetal valve having a cover portion (40) to close the cavity (32) when the lamp is cold and to open the cavity when the lamp is hot. The amalgam (22) is a metallic amalgam of, for example, mercury or other know suitable materials for establishing a metallic vapor equilibrium during operation of a discharge lamp. The amalgam holder helps to maintain optimum mercury vapor equilibrium at start-up, and to reduce the effects of mercury vapor starvation resulting from off-times.

Abstract: A method of manufacturing a low-pressure mercury vapor discharge lamp starting from a discharge vessel (10) wherein a closed holder (22) is placed which is provided with a quantity of one or more substances to be introduced in the discharge vessel (10). Subsequently, a desired gas atmosphere is brought about in the discharge vessel (10) and the discharge vessel is closed. Finally, the holder (22) is opened. According to the invention, the holder (22) is made from a leadoxide containing glass, which leadoxide is partly reduced and in which the amount of reduction is a measure of the mercury content of the holder (22). Due to the reduction process holders (22) with different mercury contents have a different color.

Abstract: A low-pressure mercury vapor discharge lamp with a discharge vessel (10) having first and second end portions (11). The discharge vessel encloses a discharge space provided with a filling of mercury and an inert gas in a gastight manner. Each end portion (11) supports an electrode (20) which is arranged in the discharge space and secured to current supply conductors (30A, 30B) which are passed through the end portion (11) so as to project outside the discharge vessel (10). A segment (31A) of at least one current supply conductor (30A), which extends between the end portion (11) and the electrode (20), is covered with an amalgam. The region (35A) is situated at a distance da from the end portion (11). The amalgam can be relatively easily applied in the discharge lamp according to the invention.

Abstract: A method for the identification of bacteria using genus, species and strain specific biomarkers. The biomarkers are generated by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of either cellular protein extracts or whole cells. Biomarkers for a number of pathogenic bacteria are disclosed.

Abstract: It is described an oxygen dispenser for use in high pressure discharge lamps. The oxygen dispenser of the invention comprises a metallic container capable of retaining solid materials but allowing an easy passage of gas, containing silver oxide. Several possible types of dispenser are proposed. The dispenser has shown capable of avoiding the formation of black deposits coming from hydrocarbons inside the lamps.

Abstract: Particle compositions are described comprising certain metal halides in combination with a strengthening agent. The addition of the strengthening agent to a metal halide particle increases the particle's strength thereby reducing breakage on impact and during handling. When used as a vaporizable metal halide fill in discharge lamps, the particle strength is increased without significantly altering the spectral and electrical characteristics of the lamp. Methods of making the particles and arc tube containing the particles are also disclosed.

Abstract: An amalgam for a fluorescent lamp. The amalgam includes mercury, tin, lead, and another metal selected from the group consisting of silver, magnesium, copper, gold, platinum, and nickel.

Abstract: In a method according to the invention, a capsule (20) having a glass wall (21) and containing mercury is positioned in a radiation-transmitting discharge vessel, after which the discharge vessel is provided with a rare gas and closed, means for maintaining an electric discharge are arranged in or adjacent the discharge vessel, and the capsule is opened by fusion after the discharge vessel has been closed in that the capsule is heated by irradiation (42) with a parallel beam of radiation through the wall of the discharge vessel. The wall of the capsule has for this radiation an absorption coefficient which amounts at least ten times that of the wall portion of the discharge vessel. The method according to the invention renders possible a comparatively simple lamp construction.

Abstract: A low-pressure mercury vapour discharge lamp according to the invention is provided with a radiation-transmitting discharge vessel (10) which encloses a discharge space (11) in a gastight manner and comprises mercury as well as a rare gas. Mercury is also present in a vapour pressure control member (21) which is in communication with the discharge space (11) during nominal operation. The discharge lamp has means (40) for maintaining a discharge in the discharge space (11). The vapour pressure control member (21) forms part of a mercury control member (20) which also comprises mercury transport control means (22) which limit the mercury transport from the discharge space (11) to the vapour pressure control member (21), at least while the lamp is out of operation, to such an extent that this transport is at most 5 ng/h.cm.sup.3, measured at room temperature and in the presence of a saturated mercury vapour in the discharge vessel, per unit volume of the discharge space.

Abstract: An integrated starting and running amalgam assembly for an electrodeless SEF fluorescent lamp includes a wire mesh amalgam support constructed to jointly optimize positions of a starting amalgam and a running amalgam in the lamp, thereby optimizing mercury vapor pressure in the lamp during both starting and steady-state operation in order to rapidly achieve and maintain high light output. The wire mesh amalgam support is constructed to support the starting amalgam toward one end thereof and the running amalgam toward the other end thereof, and the wire mesh is rolled for friction-fitting within the exhaust tube of the lamp. The positions of the starting and running amalgams on the wire mesh are jointly optimized such that high light output is achieved quickly and maintained, while avoiding any significant reduction in light output between starting and running operation.

Abstract: A plasma display panel includes a light-transmittable first substrate, a plurality of first electrodes provided in correspondence with pixels on the first substrate and partition walls provided on the first substrate so that each of the partition walls surrounds at least a part of one of the first electrodes. A Fluorescent layer is formed at a portion surrounded by the partition wall where the first electrode is located in such a manner that the first electrode surrounded by the partition wall is exposed by curing and baking a fluorescent ink having a photo-setting resin and an illuminant as its main ingredients. A light-transmittable second substrate is arranged in contact with the partition wall oppositely to the first substrate, and light-transmittable or opaque second electrodes are arranged on the second substrate oppositely to the first electrodes.

Abstract: Apparatus for providing radiation includes an envelope and a cathode arrangement disposed within the envelope. The cathode arrangement includes an element for establishing an electrical contact. A dispenser is also disposed within the envelope. The dispenser carries mercury or a mercury alloy. A support element supports the dispenser. The support element extends from the dispenser through the envelope to provide an independent electrical contact for the dispenser.

Abstract: A first portion of a spiral wire support for an amalgam is securely fitted into an exhaust tube formed in a re-entrant cavity of an electrodeless fluorescent lamp before attachment and sealing of the re-entrant cavity to the bulb of the lamp. A second portion of the spiral wire support extends into the bulb and holds an amalgam in thermal contact with the apex of the bulb. The second portion has a larger diameter than the first portion to ensure against movement of the spiral wire support into the exhaust tube. The end of the second portion of the spiral wire support is wetted with an alloy capable of forming an amalgam with mercury prior to insertion of the wire support into the exhaust tube. Mercury is added to the bulb after final evacuation of the bulb in preparation for dosing the lamp with its fill. As a result, an amalgam is formed and maintained in thermal contact with the apex of the bulb, regardless of lamp orientation.

Abstract: A scandium halide and alkali metal halide discharge lamp has a chemical fill in the arc tube comprising an inert starting gas, mercury, alkali metal iodides, scandium iodide and platinum metal as an additive for reducing the tendency of the lamps to discolor during operation.

Abstract: Cesium dispenser with a metal carrier (for example, Al or Ag) in which silicon-alkali metal compounds or germanium-alkali metal compounds are present along the grain boundaries of the carrier material.

Abstract: Alkali metal source comprises a powder of silicon or germanium grains having a shell of a compound of silicon or germanium and the alkali metal.

Abstract: A vapor-generating electric lamp includes a sealed lamp envelop having a concave depression therein, an incandescent filament mounted within the lamp envelope, a lamp base, and a replaceable, solid insert in the concave depression. The insert produces a scent when it is warmed by heat from the filament. Preferably, the insert is a polyamide impregnated with a scent and includes a portion that matches the shape of the depression in the lamp envelope. The depression for holding the insert is preferably located at the opposite end of the lamp from the base. When the lamp is used in a base-down orientation, the insert is held in the depression by gravity.

Abstract: A high pressure sodium lamp including a light permeable arc tube and an electrode extending into the arc tube via a central aperture provided in the arc tube. The electrode is supported in the aperture by means of a glass solder sealing composition. Sodium amalgam is seated in the arc tube and condensed at a corner thereof. To prevent sodium amalgam condensed at the corner of the arc tube from contacting the glass solder filled in the central aperture of the arc tube, sodium amalgam including sodium of 10-30 (wt %) is sealed in the arc tube at a prescribed volume V (mm.sup.3) which substantially satisfies the following relationship: ##EQU1## where D (mm) is the diameter of the arc tube, d (mm) is the diameter of the central aperture, Vo (mm.sup.3) is the volume of the sodium amalgam sealed in the arc tube when the shortest distance between the sodium amalgam condensed at the corner and the glass solder filled in the central aperture is given by ##EQU2## and WL (W) is the lamp power.

Abstract: An electric arc discharge switch having less susceptibility to electrode erosion and capable of being optically triggered. In a first embodiment the switch includes a gas tight body defining a hollow interior with electrodes mounted onto the body and forming a conducting path into the body interior. Portions of the body are optically transmissive to light frequencies above the photoelectric effect cutoff frequency for cesium vapor. A buffer gas and a predetermined quantity of vaporizable cesium are disposed within the hollow body interior and a flash lamp may be mounted onto the switch exterior. In operation, light frequencies above the photoelectric effect cutoff frequency for cesium are introduced into the switch body, ionizing the cesium vapor therein and reducing the resistance and breakdown voltage between the electrodes so as to initiate an electric arc. In an alternative embodiment a control plate with an aperture is disposed within the switch body between the electrodes.

Abstract: In an arc discharge device, a thin film bridges the gap(s) between adjacent electrodes, thereby enabling the arc discharge to be initiated and sustained by a low voltage D.C. supply. Application of the invention to both light source (e.g., laser) and material working (e.g., metal deposition) embodiments is described. One of the light source embodiments utilizes a cathode electrode which includes a pool of liquid Hg to generate a Hg ion plasma.

Abstract: A projection lamp comprises a single-ended metal halide arc discharge lamp disposed within a curved reflector and an interference filter disposed in front of the reflector, the filter being highly transmissive of visible light and reflective of radiation for which the metal halide, in molten salt form, is highly absorptive.