With Sample Preparation Patents (Class 356/36)
  • Patent number: 10935485
    Abstract: In one aspect, a system for performing flow cytometry is disclosed, which comprises a laser for generating laser radiation for illuminating a sample, at least one detector for detecting at least a portion of a radiation emanating from the sample in response to said illumination so as to generate a temporal signal corresponding to said detected radiation, and an analysis module for receiving said temporal signal and performing a statistical analysis of said signal based on a forward model to reconstruct an image of said sample.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: March 2, 2021
    Assignee: BD BIOSCIENCES
    Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin, Matthew Bahr
  • Patent number: 10921966
    Abstract: A digitizing device that digitizes by imaging a solid object generates three-dimensional data of the solid object by overlying second imaged data onto first imaged data on a basis of at least one node disposed inside a partial region in the first imaged data and at least one node included in the second imaged data.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: February 16, 2021
    Assignee: SHARP KABUSHIKI KAISHA
    Inventor: Tohru Nakanishi
  • Patent number: 10859488
    Abstract: A sample holder includes a slide, containing a depression in a surface of the slide. A cover slip is fixed to the slide over the depression so as to define a sample chamber, while leaving a loading area of the depression uncovered, so that a liquid sample deposited in the loading area is drawn into the sample chamber by capillary action.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: December 8, 2020
    Assignee: MES MEDICAL ELECTRONIC SYSTEMS LTD.
    Inventors: Assaf Ben Shoshan, Lior Shriki, Marcia Deutsch
  • Patent number: 10788403
    Abstract: The present invention relates to systems and methods for sequential operation of staining, imaging and sectioning of tissue samples by a processing system. After each layer of the sample is removed by the sectioning system, the system automatically stains the exposed surface of a sample to a depth to enable imaging of the remaining tissue. The system then repeats the sectioning, staining and imaging steps in sequence to image the sample.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: September 29, 2020
    Assignee: TissueVision, Inc.
    Inventors: Timothy Ragan, Chaim Moshe Dimant
  • Patent number: 10774856
    Abstract: A dust-proof and heat-control device for hydraulic cylinder is provided, including: a fixing sleeve, an annular fan mechanism, a sealing end cap and a dust cover; wherein the fixing sleeve is sleeved on a cylinder barrel of the hydraulic cylinder, the annular fan mechanism is sleeved on the fixing sleeve, the sealing end cap is disposed on an end of the cylinder barrel, a piston rod of the hydraulic cylinder passes through the sealing end cap and the dust cover, the dust cover is fixed on the piston rod, the annular fan mechanism, the dust cover and the hydraulic cylinder enclose an inner space, a side wall of the dust cover is provided with an opening communicating with the inner space, and a filter screen is mounted at the opening. The device and method can achieve good dust proof and heat control effect on axially reciprocating telescopic hydraulic cylinder.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: September 15, 2020
    Assignees: Guangdong Polytechnic Normal University
    Inventors: Yong Yang, Xiayun Liu, Shunqi Yang, Jun Yang, Shaoming Luo
  • Patent number: 10722155
    Abstract: Generating an image of a molar concentration ratio between a first and second biological substance, an absorption spectrum of the first and second biological substance within a predetermined wavelength range including a first, second, third, and fourth isosbestic point, acquiring first imaging data of the tissue using light extracted from white light using a first filter to collectively selectively extract light in a first wavelength range demarcated by the first and second isosbestic point, light in a second wavelength range demarcated by the second and third isosbestic point, and light in a third wavelength range demarcated by the third and fourth isosbestic point; acquiring second imaging data by taking an image of the tissue using light from the white light using a second optical filter to selectively extract light in the second wavelength range; and generating the distribution image on the basis of the first and second imaging data.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: July 28, 2020
    Assignee: HOYA CORPORATION
    Inventor: Toru Chiba
  • Patent number: 10704984
    Abstract: A system for evaluating the modulation transfer function (MTF) of a device under test is provided. The system includes an image projector configured to provide light in a pattern representing a desired image. The system further includes a lens configured to direct the provided light toward the device under test as a collimated beam. An image analysis component calculates the MTF for the device under test from the at least one image taken at the device under test and the known characteristics of the image projector and the lens.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: July 7, 2020
    Assignee: TRW AUTOMOTIVE U.S. LLC
    Inventors: Shaoying Kang, Robert J. Newton, Marwan Waheed, Michael L. Babala, Mohammad Masud Siraj
  • Patent number: 10697893
    Abstract: A specular variable angle absolute reflectometer. The device includes a light source and a mirror system in a light path of the light source. The mirror system is configured to reflect a light beam from the light source towards a sample that is optically reflective. The device also includes a roof mirror disposed in the light path after the sample. The roof mirror is configured to reflect the light beam back towards the sample. The device also includes a mechanism connected to the roof mirror. The mechanism is configured to rotate the roof mirror about an axis of the sample. The device also includes a detector in the light path after the roof mirror such that the detector receives light that has been reflected from the roof mirror, thence back to the sample, thence back to the mirror system, and thence to the detector.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: June 30, 2020
    Assignee: The Boeing Company
    Inventors: Loyal Bruce Shawgo, Jeffery Thomas Murphy
  • Patent number: 10656405
    Abstract: A method for image capture for colorimetric analysis includes inserting a colorimetric sample into a slot formed in a base of a device. The device includes a lid surrounding and covering the base. The lid includes a central opening, and a plurality of lights are within the lid and surrounding the opening. The method also includes selecting one or more wavelengths and intensities for illuminating the sample within the device, illuminating the sample within the device with the selected one or more wavelengths and intensities by selectively activating one or more of the plurality of lights, adjusting a height of a camera over the sample to focus the sample in the camera, and capturing at least one image of the sample using the camera.
    Type: Grant
    Filed: January 20, 2018
    Date of Patent: May 19, 2020
    Assignee: International Business Machines Corporation
    Inventors: Alvaro Bueno Buoro, Ademir Fereira da Silva, Ricardo Luis Ohta
  • Patent number: 10648906
    Abstract: In an embodiment, an optical system comprises an optical cell having an interior fluid chamber defined by an interior surface of a housing, a process inlet disposed in the housing and in fluid communication with the interior fluid chamber, and a process outlet disposed in the housing and in fluid communication with the interior fluid chamber, wherein the process inlet and process outlet facilitate the flow of a fluid through the interior fluid chamber. A sampling outlet can be disposed in the housing and in fluid communication with the interior fluid chamber. A first bi-directional pump can be in fluid communication with the sampling outlet and a first storage vessel and can be configured to withdraw a first sample of the fluid via the sampling outlet and to cause the first sample to flow into the first storage vessel.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: May 12, 2020
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Mark Erik Nelson, Arkady Samuilovich Dykman, Andrey Vladimirovich Zinenkov
  • Patent number: 10606058
    Abstract: A specimen retaining method and slide apparatus for use with microscopes to view protozoans and similar organisms in liquid cultures. The slide assembly has a rigid rectangular base made of optically clear plastic, having a shallow well for holding the liquid culture, and a thin flexible coverslip of similar shape made of optically clear plastic placeable in the slide base to cover and retain the liquid. The base has a perimeter railing that holds the coverslip in place over the well and to prevent its disturbance when handled. The well is rectangular, oriented along the length of the base. Flat ledges extend inward from these railings to support the coverslip and to define the depth of the well. The well contains narrow ridges of height corresponding to the well depth with small liquid-distribution gaps along them to support the coverslip. These ridges constrain the specimen(s) in the liquid compartments.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: March 31, 2020
    Inventor: Carol Lynn Espensen
  • Patent number: 10551321
    Abstract: The invention relates to a device (1) for detecting and/or evaluating a pathological condition comprising a Raman spectroscopy system (10) and an electronic evaluation device (20), which is configured to perform a detection and/or evaluation of the pathological condition in accordance with an evaluation of at least one Raman spectrum detected in stroma.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: February 4, 2020
    Assignee: CellTool GmbH
    Inventors: Karin Schütze, Raimund Schütze, Waldemar Lernhardt
  • Patent number: 10545151
    Abstract: The disclosure provides methods for analyzing rare circulating cells (RCCs) at cellular and molecular level following their detection in non-enriched blood samples, methods of this disclosure serve as diagnostic methods for several disease conditions, including cardiovascular diseases and cancer.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: January 28, 2020
    Assignee: Epic Sciences, Inc.
    Inventor: Dena Marrinucci
  • Patent number: 10520445
    Abstract: A Laser Induced Breakdown Spectrocopy (LIBS) system for the analysis of a sample pellet of a consolidated granular material retained in a tubular container may include a laser source configured to emit a pulsed laser beam towards an exposed surface of the sample pellet; and a sample station configured to hold the cylindrical tubular container in one or more orientations to present an exposed surface of the sample pellet towards the pulsed laser beam. The sample station may induce linear movement of the sample pellet along an axis and to expose a portion of the outer side surface of the sample pellet previously constrained through contact with an inner surface of the cylindrical tubular container. The sample station may induce rotational motion of the outer side surface of the sample pellet around the movement axis to present the portion of the outer side surface as the exposed surface.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 31, 2019
    Assignee: Foss Analytical A/S
    Inventors: Thomas Nikolajsen, Allan Kjaergaard Jensen
  • Patent number: 10483096
    Abstract: The present disclosure provides a mass spectrometry cartridge and methods of use thereof.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 19, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Nicholas Manicke, Chengsen Zhang
  • Patent number: 10481307
    Abstract: According to embodiments of the present invention, an optical antenna is provided. The optical antenna includes at least one first particle, and at least one second particle having a diameter that is larger than a diameter of the at least one first particle, wherein the at least one first particle and the at least one second particle are arranged along a plane, and wherein the at least one first particle is configured to enhance an optical emission of at least one light source providing an optical signal to the optical antenna and the at least one second particle is configured to direct the optical signal in a direction at least substantially perpendicular to the plane.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: November 19, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Arseniy Kuznetsov, Yuan Hsing Fu
  • Patent number: 10409047
    Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: September 10, 2019
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
  • Patent number: 10247672
    Abstract: A method includes: (a) providing spatially-patterned activation radiation to a sample that includes phototransformable labels, where an optical parameter of the spatially-patterned activation radiation varies periodically in space; (b) providing spatially-patterned excitation radiation to the sample, where an optical parameter of the spatially-patterned excitation radiation varies periodically in space, where (a) and (b) create a non-linear fluorescence emission pattern within the sample, the pattern including H modulation harmonics, with H>1. The method includes (c) detecting radiation emitted from the activated and excited labels, (d) storing detected radiation data, and (e) spatially shifting one or both of the spatially-patterned excitation radiation and the spatially-patterned activation radiation with respect to the sample to spatially shift the non-linear fluorescence emission pattern within the sample, and (f) repeating (a)-(e) at least N times, with N>2.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: April 2, 2019
    Assignee: Howard Hughes Medical Institute
    Inventors: Robert E. Betzig, Dong Li
  • Patent number: 10184902
    Abstract: A substrate surface information detection device and a substrate surface information detection method are disclosed. The device includes a spray source and an image sensor, wherein the spray source is configured to uniformly spray droplets onto a surface of a substrate-under-test or form a liquid flow on the surface of the substrate-under-test, and the image sensor is configured to record image information of the droplets or the liquid flow. According to the substrate surface information detection device and substrate surface information detection method, defects on the surface of the substrate before the PI coating can be prevented and avoided, the production time can be shortened, and the production efficiency can be promoted and the product yield can be improved.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: January 22, 2019
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventors: Yuguang Fan, Jingpeng Li, Jian Li, Shichao Wang, Limin Tian
  • Patent number: 9958430
    Abstract: The invention relates to the field of medicine and biology. A device for monitoring of spatial coagulation of blood and its uses for diagnostic and research purposes is described. The device includes a thermostatically controlled chamber, at least one means of illumination, a means of recording connected to the thermostatically controlled chamber. The thermostatically controlled chamber includes a cuvette to place a sample of a test medium, a light trap, and is filled with a substance suitable for temperature regulation. The light trap is formed by geometry of the inner surfaces of the thermostatically controlled chamber.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: May 1, 2018
    Assignee: OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU <<GEMATOLOGICHESKAYA KORPORATSIYA
    Inventors: Fazoil Inoyatovich Ataullakhanov, Vasilii Ivanovich Sarbash, Mikhail Aleksandrovich Panteleev, Sergey Sergeevich Karamzin
  • Patent number: 9950483
    Abstract: The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: April 24, 2018
    Assignee: Novartis AG
    Inventors: Xinming Qian, Frank Chang, Troy Vernon Holland, Yongxing Qiu, Venkat Shankar
  • Patent number: 9928213
    Abstract: A method of processing asynchronous event-driven input samples of a continuous time signal includes calculating a short-time Fourier transform (STFT) output based on the event-driven input samples. The STFT output may be calculated by expressing an encoding pulse and an STFT window function as a sum of complex weighted causal complex exponentials. The method further includes interpolating output between events.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: March 27, 2018
    Assignee: QUALCOMM Incorporated
    Inventors: Xin Wang, Young Cheul Yoon, Bardia Fallah Behabadi
  • Patent number: 9915615
    Abstract: A method of testing an organic sample to provide an indication of the level of bacteria and/or number of somatic cells present in the sample, the method including collecting the sample and contacting the sample with a reagent which reacts with ATP to produce light emissions, and subsequently, at the beginning (O) of a measurement period (A, B), contacting the sample with an extractant in the presence of the reagent, the extractant rupturing cells present in the sample to release cell-bound ATP to react with the reagent to produce light emissions, and immediately after contacting the sample with the extractant, detecting the light emissions with a light detecting device (18), and the method includes during an initial measurement period (A) immediately after contacting the sample with the extractant, detecting the level of light emissions, and in a subsequent measurement period (B), detecting the level of light emissions, statistically analyzing the detected values to determine a rate of change of light emissio
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: March 13, 2018
    Assignee: KRYSIUM TECHNOLOGIES LIMITED
    Inventors: Maurice William Thompson, Andrew Prail, David Kent Wright
  • Patent number: 9878594
    Abstract: A thermal management system for a vehicle includes a first pump and a second pump, temperature adjustment target devices, heat exchangers, numerous flow paths including a first pump arrangement flow path, a second pump arrangement flow path, and device arrangement flow paths, a first switching portion for allowing the numerous flow paths to selectively communicate with each other, a second switching portion for allowing the numerous flow paths to selectively communicate with each other, and a reserve tank for storing therein heat medium. The reserve tank is configured to set the pressure of the liquid surface of the stored heat medium to a predetermined pressure (e.g., atmospheric pressure), and is connected to one flow path of the numerous flow paths.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: January 30, 2018
    Assignee: DENSO CORPORATION
    Inventors: Norihiko Enomoto, Nobuharu Kakehashi, Michio Nishikawa, Masamichi Makihara, Kazutoshi Kuwayama, Yoshiki Katoh, Kengo Sugimura
  • Patent number: 9869615
    Abstract: A sample dispersion device capable of preparing a measurement sample in the most suitable dispersion state without repreparing the measurement sample many times, is one that by introducing sample particles into a container and injecting the sample particles in the container using a pressure difference, disperses sample particles onto a holding member provided in a container to make the holding member hold the sample particles. The holding member has a holding surface made to hold the sample particles; and the holding surface has multiple portions having mutually different tilt angles.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: January 16, 2018
    Assignee: HORIBA, LTD.
    Inventors: Kusuo Ueno, Tomoya Shimizu
  • Patent number: 9857340
    Abstract: A method and apparatus for detecting mercury in air includes passing a substantial quantity of air through a concentrator column containing gold film whereby a gold-mercury amalgam is formed, purging the concentrator column with nitrogen gas for a predefined period of time to remove oxygen and other organics from the concentrator column, quickly heating the concentrator column to a substantial temperature to decompose the gold-mercury amalgam forming mercury gas, and injecting the mercury gas into a photoionization detector system. The apparatus includes a quartz housing having a quartz body defining an internal volume, a gas inlet, a gas outlet, and a heater end, and a concentrator element sealingly disposed within the quartz housing, the concentrator element having a first element portion and a second element portion, a film of gold deposited on at least a first element portion disposed in the quartz body.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: January 2, 2018
    Inventor: John N. Driscoll
  • Patent number: 9784960
    Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: October 10, 2017
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Garth Jason Simpson, Charles Addison Bouman, Ryan Douglas Muir, Shane Sullivan, Justin Allen Newman, Mark Carlsen, Suhas Sreehari
  • Patent number: 9779330
    Abstract: A method and non-transitory computer-readable medium capture an image of bulk grain and apply a feature extractor to the image to determine a feature of the bulk grain in the image. For each of a plurality of different sampling locations in the image, based upon the feature of the bulk grain at the sampling location, a determination is made regarding a classification score for the presence of a classification of material at the sampling location. A quality of the bulk grain of the image is determined based upon an aggregation of the classification scores for the presence of the classification of material at the sampling locations.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: October 3, 2017
    Assignee: Deere & Company
    Inventors: Carl Knox Wellington, Aaron J. Bruns, Victor S. Sierra, James J. Phelan, John M. Hageman, Cristian Dima, Hanke Boesch, Herman Herman, Zachary Abraham Pezzementi, Cason Robert Male, Joan Campoy, Carlos Vallespi-gonzalez
  • Patent number: 9739897
    Abstract: The disclosure relates to lanthanum-yttrium oxide scintillators used for detecting radiation, such as X-rays, gamma rays and thermal neutron radiation and charged particles, in security, medical imaging, particle physics and other applications.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: August 22, 2017
    Assignee: Board of Regents, the University of Texas System
    Inventor: Wei Chen
  • Patent number: 9719917
    Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: August 1, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Hakan Frojdh, Mikael Hornqvist, Stig Tormod, Patrik Akerstrom
  • Patent number: 9638669
    Abstract: A portable fuel dilution meter and method includes a plurality of sample bottles each with a lid securable thereto and an absorbent material in the bottle. A housing includes a sample bottle receptacle and a hinged head unit over the receptacle including at least a first needle piercing the lid of a sample bottle loaded into the housing receptacle and extending into the headspace of the sample bottle when the head is closed. A vapor sensor is fluidly coupled to the first needle for analyzing vapors in the headspace of the sample bottle.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: May 2, 2017
    Assignee: Spectro Scientific, Inc.
    Inventors: Eric J. Olson, Henry Wohltjen, Yuegang Zhao
  • Patent number: 9589173
    Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: March 7, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Peter T. C. So, Bevin Engelward, Timothy Ragan, Karsten Bahlman, Ki-Hean Kim, Lily Hsu Laiho, Hayden Huang
  • Patent number: 9482600
    Abstract: A sample collection unit for microbiological air analysis includes a housing and a sample treatment path. The housing has a sample inlet opening, an optical window, and an air outlet opening. The sample treatment path has a conjugation pad, and a test strip with a test area and an absorber section. The sample collection unit also has a device configured to receive a container for a solvent, and a device configured to release the solvent. The sample collection unit is preferably configured as a disposable component in the form of a cartridge. Integration of the container for the solvent in the sample collection unit permits simplification and automation of the corresponding sampling method.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: November 1, 2016
    Assignee: Robert Bosch GmbH
    Inventors: Petra Neff, Mike Uhlig, Andreas Neumann
  • Patent number: 9422523
    Abstract: Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and techniques for the process are described so that commercial applications of sperms samples as well as the resulting animals may be achieved.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: August 23, 2016
    Assignee: XY, LLC
    Inventors: George E. Seidel, Lisa A. Herickhoff, John L. Schenk
  • Patent number: 9410978
    Abstract: A liquid sample loader for an analytical instrument includes a sample holder with a sample well for holding a liquid sample and a sample passageway extending upwardly at an inclined angle from a bottom portion of the well, a pump positioned upstream from the sample holder and an upstream passageway coupled between the sample and the pump. A controller controls the pump to push the sample in the sample well downstream through the sample passageway toward the measuring instrument.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: August 9, 2016
    Inventor: Jeff Wagner
  • Patent number: 9404862
    Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22?), wherein the at least one UV-transparent window (22?) is made of a polymer material and has been subjected to Gamma radiation sterilization. In one aspect, the flow cell is combustible.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: August 2, 2016
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Hanno Ehring
  • Patent number: 9354143
    Abstract: A device for the automated isolation and transfer of at least one microscopic sample from a sample carrier to a collecting system for subsequent automatic analysis is provided. The device comprises a selection unit for selecting at least one sample located on the sample carrier, a controllable isolation unit for the automated isolation of the at least one selected sample, a controllable transfer unit, which has carrier means for the defined receiving and deposition of the at least one selected isolated sample, for an automated and defined transfer of the at least one selected isolated sample from the sample carrier to the collecting system, and a control unit, which has a data link to the selection unit, the isolation unit and the transfer unit, for an automated isolation and transfer operation.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: May 31, 2016
    Assignee: HELMHOLTZ ZENTRUM MUNCHEN DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)
    Inventor: Stefan Thalhammer
  • Patent number: 9349050
    Abstract: Plural of virtual curved surface solids, each of which is a curved surface solid formed by a combination of plural of virtual spheres, is placed so as to fill in space voxels, referring to porous-body data in which positional information is associated with voxel-type information (step S100). Information regarding a flow rate for each space voxel when a fluid passes through a porous body is derived by executing a fluid analysis based on the porous-body data (step S110). A flow-rate-weighted mean diameter Ru, which is a weighted average obtained by weighting an equivalent diameter R?i for each virtual curved surface solid with a volume Vi and an average flow rate Ui for each virtual curved surface solid, is derived based an information regarding the virtual curved surface solids and information regarding the flow rate for each space voxel (step S120).
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: May 24, 2016
    Assignee: NGK Insulators, Ltd.
    Inventors: Satoshi Sakashita, Hiroyuki Nagaoka, Ayaka Sakai
  • Patent number: 9329108
    Abstract: Liquid sample basins for use in assemblies for handling samples for analysis in an analytical stream. The sample basins have a body defining a basin for receiving a liquid sample. The basin has a cylindrical opening at an upper surface of the body through which the sample may be introduced. A drain is provided at the lower end of the basin, and the basin is adapted to direct flow of the sample from the basin into and downward through the drain. A wash ring is mounted on top of the body around the basin opening. The assembly of the wash ring and the body defines a manifold extending around the basin opening and provides a conduit for flow of wash solvent around the opening. The wash ring and body assembly also has one or more ports adapted to direct wash solvent from the manifold into the basin.
    Type: Grant
    Filed: November 30, 2013
    Date of Patent: May 3, 2016
    Inventor: Jack Delaney Horn, Jr.
  • Patent number: 9290372
    Abstract: A fluid distributor for uniformly distributing flow of a feed onto a chromatography column in a cost-effective way defines a distribution channel of generally conical shape between a solid back plate and a packed bed in the column, wherein the fluid distributor comprises at least two circular and/or annular fluid-permeable porous disks essentially filling the volume of the distribution channel.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: March 22, 2016
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Peter Bellqvist, Klaus Gebauer
  • Patent number: 9222883
    Abstract: An optical measuring system includes at least one radiation source, at least one radiation receiver, and at least one flow through cell. The radiation emitted by the at least one radiation source passes at least partially in an optical path between the radiation source and the radiation receiver through the flow through cell and then strikes the at least one radiation receiver. The radiation receiver is embodied to output a signal dependent on the intensity of the radiation striking the radiation receiver, wherein the flow through cell is arranged in a cell holder, which is connected via a first connection interface releasably with the radiation receiver and which is connected via a second connection interface releasably with the radiation source.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: December 29, 2015
    Assignee: Endress + Hauser Conducta Gesellschaft für Mess—und Regeltechnik mbH + Co. KG
    Inventors: Michael Weiss, Guido Mertens
  • Patent number: 9186668
    Abstract: Embodiments of the present invention are directed toward microfluidic systems, apparatus, and methods for measuring a quantity of cells in a fluid. Examples include a differential white blood cell measurement using a centrifugal microfluidic system. A method may include introducing a fluid sample containing a quantity of cells into a microfluidic channel defined in part by a substrate. The quantity of cells may be transported toward a detection region defined in part by the substrate, wherein the detection region contains a density media, and wherein the density media has a density lower than a density of the cells and higher than a density of the fluid sample. The substrate may be spun such that at least a portion of the quantity of cells are transported through the density media. Signals may be detected from label moieties affixed to the cells.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: November 17, 2015
    Assignee: Sandia Corporation
    Inventors: Ulrich Y. Schaff, Gregory J. Sommer, Anup K. Singh
  • Patent number: 9097701
    Abstract: An apparatus for hemolyzing a blood sample and for measuring at least one parameter thereof comprises a sample chamber for accommodation of the blood sample, the sample chamber having a first sidewall and an opposite second sidewall. The apparatus also comprises ultrasonic generator for generating ultrasonic waves in the first and second sidewalls so as to cause the blood sample provided between the first and second sidewall to be hemolyzed. Further, the apparatus comprises an optical measuring device for measuring the at least one parameter in the hemolyzed blood sample when the hemolyzed blood sample is provided between the first and second sidewalls. The ultrasonic generator of the apparatus comprises a first ultrasonic generator for generating ultrasonic waves in the first sidewall and a second ultrasonic generator for generating ultrasonic waves in the second sidewall.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: August 4, 2015
    Assignee: Radiometer Medical ApS
    Inventor: Søren Christian Krogh
  • Patent number: 9080208
    Abstract: A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in a carrier-liquid conduit comprising a stabilization feature and (b) proximate to the stabilization feature, the encapsulating liquid being immiscible with the carrier liquid, so that the discharged encapsulating liquid does not mix with the carrier liquid, floats on top of the carrier liquid, and is immobilized by the stabilization feature; drawing a sample liquid from a sample-liquid input; and discharging the drawn sample liquid, the sample liquid being immiscible with the encapsulating liquid and with the carrier liquid, so that the sample liquid does not mix with the encapsulating liquid or with the carrier liquid.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: July 14, 2015
    Assignee: GenCell Biosystems Ltd.
    Inventors: Kieran Curran, Paul Fleming, Séamus Gillhooley, Micheál Keane, Inga Rosca, Patrick Tuohy
  • Publication number: 20150138532
    Abstract: Motion strategies in two and three dimensions for scanning microscope imaging are described. An object, sample, or specimen is mounted on a precision three-dimensional stage. The object is moved concurrently with respect to a first axis and a second axis orthogonal to the first against a cutting tool to cut the object. An image of the cut portion is generated as the object is moved. The cutting tool may act as an optical waveguide for illuminating the portion of the object cut. An optical element captures images of the cut and illuminated object. The object may further be concurrently moved with respect to a third axis orthogonal to both the first and second.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 21, 2015
    Inventors: Matthew GOODMAN, Cody DANIEL
  • Patent number: 8986943
    Abstract: A pre-treatment method for analyzing a specified portion in a specimen composed of a biological tissue includes the steps of preparing a specimen to be analyzed, determining a specified portion in the specimen; and applying an analysis inhibitor to a portion except the specified portion of the specimen using a droplet spray method.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 24, 2015
    Assignee: Canon Kabushiki Kaisha
    Inventors: Yohei Murayama, Hiroyuki Hashimoto, Manabu Komatsu, Kazuhiro Ban
  • Publication number: 20150042978
    Abstract: Methods and systems for setting up a wafer inspection process using programmed defects are provided. One method includes altering a design for a dummy area of a production chip such that printing of the dummy area on a wafer results in printing of a variety of defects. Two or more of the defects have different types, one or more different characteristics, different contexts in the design, or a combination thereof. The dummy area printed on a wafer may then be scanned with two or more optical modes of an inspection system to determine which of the optical mode(s) are better for defect detection. Additional areas of the wafer may then be scanned with the optical mode(s) that are better for defect detection to determine noise information. The noise information may then be used to select one or more of the optical modes for use in a wafer inspection process.
    Type: Application
    Filed: June 13, 2014
    Publication date: February 12, 2015
    Inventor: Graham Michael Lynch
  • Patent number: 8945866
    Abstract: Methods and devices for cutting and collecting dissected specimens are described herein.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: February 3, 2015
    Assignee: Molecular Machines and Industries AG
    Inventor: Stefan Niehren
  • Publication number: 20150029491
    Abstract: A apparatus for microfluid detection for detecting a sample fluid including a plurality of magnetic particles is provided. The apparatus for microfluid detection includes a microfluidic chip and a magnetic generating module. The microfluidic chip includes a substrate and microfluidic channels, wherein the sample fluid is carried by a carry surface of the substrate. The magnetic generating module is adapted for providing a positioning magnetic field and a surrounding magnetic field. The magnetic module controls to move the sample fluid and change a distribution of the magnetic particles in the sample fluid through the positioning magnetic field and the surrounding magnetic field.
    Type: Application
    Filed: March 21, 2014
    Publication date: January 29, 2015
    Applicant: Industrial Technology Research Institute
    Inventors: Liang-Ju Chien, Chi-Han Chiou, Shao-Hsing Yeh, Yu-Ying Lin
  • Publication number: 20150009487
    Abstract: Thickness and group index variations in test strip samples of ultra-low expansion glass are made by extracting the strip samples with front and back faces oriented at an acute skew angle to the axis of the boule. The strip samples are positioned the within an interferometric measurement cavity so that a set of subcavities formed by pairings of each of two reference surfaces together with each of the front and back faces of the strip sample which each subcavity having a different optical path length spacing. The skew angle is sized to avoid diffusion effects of striae present in the boule.
    Type: Application
    Filed: June 30, 2014
    Publication date: January 8, 2015
    Inventors: Paul Gerard Dewa, Thomas James Dunn, Robert Dennis Grejda, Christopher Alan Lee