Included With Sample Excitation Patents (Class 356/417)
  • Patent number: 11397148
    Abstract: The method of analyzing absorbance of one or more liquid samples arranged in the wells of a microplate includes the steps of setting a desired wavelength falling within the wavelength range of 380 nm-750 nm for absorbance measurement, illuminating the samples using electromagnetic radiation having a bandwidth of at most 20 nm around the set wavelength, measuring radiant flux transmitted through each sample, on the basis of measured radiant flux values, determining an absorbance value for each sample, and visualizing the absorbance values on a display as a matrix comprising a plurality of cells, each cell corresponding to a well of the microplate. The set wavelength is used as an input for determining the visual properties of the cells.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: July 26, 2022
    Inventors: Adyary Fallarero, Marika J. Raitio, Tommi Suvanto, Katja Eklin
  • Patent number: 11265449
    Abstract: A microscope-based system and a method for image-guided microscopic illumination are provided. The microscope-based system for image-guided microscopic illumination comprises a microscope, an illuminating assembly, an imaging assembly, a first processing module, and a second processing module. The microscope comprises a stage, and the stage is configured to be loaded with a sample. The imaging assembly comprises a camera. The processing modules are coupled to the microscope, the imaging assembly, and the illuminating assembly.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: March 1, 2022
    Inventors: Jung-Chi Liao, Yi-De Chen, Chih-Wei Chang, Weng Man Chong
  • Patent number: 11219370
    Abstract: Currently most cancers, including breast cancers, are removed without any intraoperative margin control. Post-operative methods inspect 1-2% of the surgical margin and are prone to sampling errors. The present invention relates to an optical imaging system that will enable evaluation of the surgical margin in vivo and in real-time. The invention provides for simultaneous fluorescence and fluorescence polarization imaging. The contrast of the acquired images will be enhanced using fluorescent agents approved for diagnostic use in patients. As the staining pattern of fluorescence images is similar to that of histology, and the values of fluorescence polarization are significantly higher in cancerous as compared to normal cells, the invention provides for further improvements in diagnostic methods. The systems and methods can be applied to the intra-operative delineation of cancerous tissue.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: January 11, 2022
    Inventors: Anna N. Yaroslavsky, Rakesh Patel, Dennis Wirth
  • Patent number: 11163064
    Abstract: A system comprises an imaging device that includes a two dimensional array of pixels. Each pixel of the array includes a first optical filter having a first pass band arranged to filter excitation light reflected by a moving object and a first detector configured to detect light transmitted through the first optical filter and to generate a first electrical signal. Each pixel of the array also includes a second optical filter having a second pass band arranged to filter excitation light reflected by a moving object and a second detector configured to detect light transmitted through the second optical filter and to generate a second electrical signal. The imaging device further includes circuitry that generates output signals from each of the pixels based on the first electrical signal and the second electrical signal of the pixel. The output signal includes information about the speed and direction of the moving object.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: November 2, 2021
    Assignee: Palo Alto Research Center Incorporated
    Inventors: John Knights, Alex Hegyi, Peter Kiesel
  • Patent number: 11092791
    Abstract: An auto-focusing method for determining an in-focus position of a plurality of wells in at least a portion of a multi-well plate, the method including using a first objective lens having a first magnification to identify, in each of at least three wells of a selected subset of the plurality of wells, an in-focus position of each well with respect to the first objective lens, on the basis of at least three the in-focus positions, computing a plane along which the at least three wells will be in focus with respect to at least one objective lens having a second magnification that is not greater than the first magnification, and using the at least one objective lens to scan, along the plane, at least some of the plurality of wells in the portion of the plate.
    Type: Grant
    Filed: May 27, 2019
    Date of Patent: August 17, 2021
    Inventors: Shlomo Turgeman, Yael Paran, Alex Efros
  • Patent number: 11009466
    Abstract: A discharge detection system includes a plurality of optical fibers having different optical distances from each other and provided to allow discharge light generated from a test object to enter at least one of the optical fibers, an optical sensor configured to detect the discharge light having entered the at least one of the optical fibers and to output a detection signal having a temporal change in an amplitude of the detection signal, the temporal change in the amplitude corresponding to a temporal change in intensity of the discharge light, and a signal processing system configured to identify an area where the discharge light is generated based a point of time of at least one peak in the detection signal.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: May 18, 2021
    Inventors: Takayuki Nishi, Shinya Ohtsuka
  • Patent number: 10989660
    Abstract: An automatic fluorescence detection system includes a base and an optical assembly. The base has a detecting region. The optical assembly includes a fluorescent image-capturing device, an illumination device and a field lens. The illumination device includes a first annular illumination module and a second annular illumination module surrounding a center axis of the fluorescent image-capturing device. Lights emitted by the first annular illumination module and the second annular illumination module travel along a light-traveling path to project onto the detecting region. A distance between the first annular illumination module and the center axis is smaller than that between the second annular illumination module and the center axis. The field lens is disposed in correspondence with the detecting region. Spacing between the field lens and the detecting region is ranged from 15.0 cm to 30.0 cm.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: April 27, 2021
    Assignee: CHROMA ATE INC.
    Inventors: Chien-Hsun Chu, Lan-Sheng Yang
  • Patent number: 10983320
    Abstract: An optical arrangement (10) for imaging a sample (20). The arrangement comprises an illumination objective lens (30) for producing an illumination beam (40) and a detection objective lens (50) for imaging radiation (60) from the sample (20). The illumination objective lens (30) is arranged at a non-perpendicular angle to the detection objective lens (50).
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: April 20, 2021
    Inventors: Lars Hufnagel, Uros Krzic
  • Patent number: 10942120
    Abstract: An apparatus for the high throughput measurement of optical properties of liquid samples placed into the wells of a multiwell plate is disclosed. An optical fiber within a fiber bundle containing no corrective optics between the fiber ends and the well plate bottom illuminates the sample in order to induce fluorescence, and multiple fibers collect emission radiation and transmit it to a fluorescence detector such as a spectrometer. Other embodiments involve a light scattering illumination source with detection fibers located in either the same bundle containing the fluorescence monitoring fibers or an independent light scattering detection bundle for the measurement of static and/or dynamic light scattering. Some embodiments of the invention permit the measurement of phase analysis light scattering. Thus the measurement of multiple optical properties of a liquid sample may be made simultaneously or in succession. A method for these measurements is also disclosed.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: March 9, 2021
    Inventors: Vincent Hsieh, Mario Yasa, Jr., Steven C. Minne
  • Patent number: 10928407
    Abstract: Systems and methods for dynamic automation are provided. An automation module may receive at least one map template that is selectable by a user. Based on the map template, the automation module may dynamically generate a robot deck layout map and/or procedure and also generate a series of robotic commands for a robot. The robotic commands may then be passed to the robot to carry out the automation. Accordingly, the automation may be entirely dynamic, without the need for a user to pre-program or pre-assemble all of the robotic commands prior to the automation. The automation module may thus be able to build, in real-time and/or on the fly, the robotic commands based only on the at least one map template that was selected by the user.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: February 23, 2021
    Assignee: Lonza Limited
    Inventors: Dale Webster, Evan Carpenter
  • Patent number: 10914932
    Abstract: It is aimed to prevent excitation light from leaking and being detected by the detector in a fluorescence microscope. A microscope includes an illumination optical system configured to illuminate a specimen with excitation light, a detector configured to detect fluorescence emitted from the specimen, and an observation optical system configured to guide the fluorescence to the detector. The observation optical system includes an optical filter having a variable wavelength characteristic, a light dispersing element configured to disperse, into light beams, light that has passed through the optical filter, and a light block plate configured to block at least some of the light beams resulting from the dispersion by the light dispersing element.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: February 9, 2021
    Inventors: Shota Tsuchida, Kei Horie
  • Patent number: 10908065
    Abstract: An optical arrangement receives output light emanating from an object disposed within a fluid column that crosses an optical refraction boundary of the fluid column between the object and the optical arrangement. The optical arrangement modifies the output light such that the modified output light has an intensity that is more uniform than the output light.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: February 2, 2021
    Assignee: Inguran, LLC
    Inventors: Alex Hegyi, Peter Kiesel, Kenneth M. Evans
  • Patent number: 10768402
    Abstract: Systems and methods are provided for evaluating a fresh tissue sample, prepared as to fluoresce under illumination, during a medical procedure. A structured light source is configured to project a spatially patterned light beam onto the fresh tissue sample. An imaging system is configured to produce an image from fluorescence emitted from the illuminated fresh tissue sample. A system control is configured to provide a human-comprehensible clinically useful output associated with the medical procedure.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: September 8, 2020
    Inventor: Jonathon Quincy Brown
  • Patent number: 10487360
    Abstract: The present invention provides a method for determining whether an individual with relapsing-remitting multiple sclerosis will suffer a relapse or respond to treatment for MS. A ratio of mRNA levels of Response Gene to Complement-32, FasL or IL-21 to L13 determined for an individual provides a normalized level which is compared to a cut-off value. A normalized level of Response Gene to Complement-32 greater than 2.52, a normalized level of FasL greater than 85.4 and a normalized level of IL-21 less than 11.9, respectively, indicates the individual will have or is having a relapse of multiple sclerosis. Also provided are methods for determining whether an individual will respond positively or is responding positively to glatiramer treatment and whether the individual is in a period of stable disease or is not at risk for relapse of multiple sclerosis by comparing normalized levels with the respective cut-off levels.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: November 26, 2019
    Assignees: University of Maryland, Baltimore, The Department of Veterans Affairs
    Inventors: Horea Rus, Cornelia Cudrici, Cosmin Tegla
  • Patent number: 10295784
    Abstract: An imaging system for directing one or more optical signals to one or more imaging elements is provided. The imaging system may include an optical element tray. The optical element tray may include optical elements having optical characteristics different from each other. The optical element tray may be configured to be moveable to form one or more optical paths each allowing an optical signal to travel to an imaging element through none, one, or several of the optical elements. In various embodiments, the one or more optical paths may each be selected from a plurality of linear and nonlinear paths formed by the optical elements in the optical element tray and/or additional optical elements external to the optical element tray. In some embodiments, the optical element tray may be moveable along its axis of rotation and/or rotated to enhance image stability of the imaging system.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 21, 2019
    Inventor: Xing Du
  • Patent number: 10247906
    Abstract: A system for directing light to an imaging element is provided. The system may include an optical element tray. The optical element tray may include optical elements having optical characteristics different from each other. The optical element tray may be configured to be moveable to form an optical path allowing the light to travel to the imaging element through none, one, or several of the optical elements. In various embodiments, the optical path may be selected from a plurality of linear and nonlinear paths formed by one or more optical openings, one or more optical channels, and optical reflectors.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: April 2, 2019
    Inventor: Xing Du
  • Patent number: 10156501
    Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 18, 2018
    Inventors: Thomas M. Baer, Michael G. Youngquist, Brian W. Donovan, Alan E. Wessel, Norbert H. Leclerc, Michael A. Smith, Craig S. Barker, George M. Dawson
  • Patent number: 10126539
    Abstract: An imaging system consisting of a cell-phone with camera as the detection part of an optical train which includes other components. Optionally, an illumination system to create controlled contrast in the sample. Uses include but are not limited to disease diagnosis, symptom analysis, and post-procedure monitoring, and other applications to humans, animals, and plants.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: November 13, 2018
    Inventors: Daniel Fletcher, Wendy Hansen, Neil Switz, David N. Breslauer, Erik Douglas, Robi Maamari, Wilbur Lam, Jesse Dill
  • Patent number: 10126231
    Abstract: Systems and methods for examining spectral data over the course of a high speed event are described. The systems and methods can enable observation of the spectral evolution of a transient phenomenon into segment intervals on the order of, milliseconds or microseconds. The methods include reflecting light from an event off of a rotating mirror and sequentially delivering light from the mirror to a series of optical waveguides for sequential spectral analysis. The systems and methods can be useful in a wide variety of applications such as, LIBS applications; examination of high energy devices such as explosions or simulations of explosions; examination of deposition processes, e.g., coating formations; examination of chemical reactions; etc.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: November 13, 2018
    Assignee: Savannah River Nuclear Solutions, LLC
    Inventors: Eliel Villa-Aleman, William A. Spencer
  • Patent number: 10012758
    Abstract: Solid state lasers are disclosed herein. An example laser disclosed herein includes a monolithic body having a first end and a second end. The monolithic body includes a first reflector disposed on the first end, a second reflector disposed on the second end, and a solid state gain medium and a Q-switch disposed between the first reflector and the second reflector. The example laser also includes a pump source to cause a population inversion in the solid state gain medium to cause the monolithic body to output a laser pulse. Various applications of the solid state laser are also disclosed herein.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: July 3, 2018
    Inventors: Andrew J. Speck, A. Ballard Andrews
  • Patent number: 9970868
    Abstract: Described are devices, methods, and systems that are suitable for rapidly and simultaneously determining the concentration of suspended particles in a sample. The devices, methods, and systems allow for the rapid and simultaneous interrogation of a large number of sample wells in a single vessel, for example, samples contained in a two-dimensional array or micro-titer plate, without the need for moving reading heads or moving the sample vessel. The nephelometry system allows the user to rapidly and simultaneously measure the concentration of the particles in numerous samples, adjust the concentration of the particles in the sample with a sample handling system, and re-measure the concentration of the samples in order to achieve a desired concentration.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: May 15, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Klaus W. Berndt, Timothy R. Hansen
  • Patent number: 9930198
    Abstract: An image reading apparatus and an image forming system which are hardly affected by noise due to paper dust or the like is provided. An image reading apparatus includes a back side image reading unit and a front side image reading unit which are continuously arranged in a sheet conveying direction. Also, an upstream side conveyance member and an intermediate conveyance member are arranged adjacent to each other in the upstream and downstream sides of the back side image reading unit. The intermediate conveyance member and the downstream side conveyance member are arranged adjacent to each other in the upstream and downstream sides of the front side image reading unit. The colorimetric unit is arranged outside an area from the upstream side conveyance member to the downstream side conveyance member in the sheet conveying direction.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: March 27, 2018
    Assignee: Konica Minolta, Inc.
    Inventor: Hiroshi Isokawa
  • Patent number: 9909970
    Abstract: Disclosed is a method of calibrating apparatus for optically characterizing samples of particles of small size. Also disclosed is a method of estimating the concentration of particles in a population of small size particles.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: March 6, 2018
    Assignee: Malvern Instruments Limited
    Inventors: John Patrick Hole, Jonathan Benjamin Kendall Smith, Ian John Wilson, Andrew Paul Malloy
  • Patent number: 9895692
    Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: February 20, 2018
    Assignee: Micronics, Inc.
    Inventors: C. Frederick Battrell, Isaac Sprague, Matthew Scott Bragd, Jason Capodanno
  • Patent number: 9885658
    Abstract: A method for manufacturing a biochip having improved fluorescent signal sensing properties, and a biochip manufactured by the manufacturing method. A filter layer is provided between a bio-layer and a light sensor layer so as to remove noise generated by stray light during a bio-reaction process. Thereby, the sensitivity of the light sensor layer can be enhanced.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: February 6, 2018
    Inventor: Do Young Lee
  • Patent number: 9814375
    Abstract: A light source device includes: excitation light sources configured to emit a plurality of excitation light including mutually different spectra; wavelength converting members configured to wavelength-convert the excitation light emitted from the excitation light sources into light having mutually different spectra and configured to be disposed in a common application region of the excitation light; and a light source control unit configured to switch a combination of the excitation light sources that are lighted among the excitation light sources based on the observation mode including a normal light observation mode and a special light observation mode to highlight a particular observation target input to an input unit, wherein light emitted from the wavelength converting members is used as illumination light, and the illumination light corresponding to the observation modes is emitted from a same emitting portion.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: November 14, 2017
    Inventors: Bakusui Daidoji, Kazuaki Tamura, Takeshi Ito, Hiroyuki Kamee
  • Patent number: 9669001
    Abstract: A composition for use on skin and wounds, comprising a photo-catalyst which is capable of preferentially staining biofilms the composition being for use in the diagnosis and treatment of biofilms in wounds.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: June 6, 2017
    Inventors: Phillip Godfrey Bowler, Daniel Gary Metcalf, David Parsons
  • Patent number: 9645291
    Abstract: A series combination of a shortwave pass (SWP) filter and a longwave pass (LWP) filter is provided in an arrangement where the filters are separately and independently controlled by voltages applied to the respective filters. The applied voltages modify the response profile of the associated filters, where changes in the voltage applied to the SWP filter changes its cut-off wavelength ?S and changes in the voltage applied to the LWP filter changes its cut-on wavelength ?L (the bandwidth of the combined arrangement between the span between ?L and ?S). The ability to independently tune both the SWP and LWP filters allows for the combined result of their series combination to modify both the center wavelength (CWL) and bandwidth (BW) of the overall filter resulting from their combination.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 9, 2017
    Assignee: II-VI Incorporated
    Inventors: Thomas Radford Sommer, William Kastanis
  • Patent number: 9452429
    Abstract: A method for performing multiplexed bead-based immunoassays using a microfluidic cassette capable of detecting a particle passing in substantially single file through an interrogation zone and generating a Coulter effect signal responsive to a characteristic of the particle. A fluid sample may be prepared by associating antibody-coated beads of different sizes to particles of interest. A first multiplexing option may be based on bead size, in which case the intensity of the Coulter signal is used to sort or characterize the particles. A second multiplexing option may be based on detection of Stokes' shift phenomena, or even simply emission intensity, in which case particles may be characterized responsive to intensity of the signal resulting from detection of radiation. The first and second multiplexing options may be employed together to populate an array of particle characteristics.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: September 27, 2016
    Assignee: E. I. SPECTRA, LLC
    Inventor: Harold E. Ayliffe
  • Patent number: 9341562
    Abstract: A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: May 17, 2016
    Inventors: Joerg Martini, Peter Kiesel, Malte Huck, Marshall W. Bern, Noble M. Johnson, Michael Bassler, Markus Beck
  • Patent number: 9328380
    Abstract: A real time analysis in accordance with temperature change and highly sensitive detection are permitted. A flow passage device has a flow passage (1) and is able to heat a fluid in the flow passage. A state of the fluid in the flow passage is observable using light. The flow passage device includes a first member (2) including an observation surface (3) and an upper inner wall surface (4), and a second member (5) including a lower inner wall surface that opposes the upper inner wall surface (4) and that is part of inner walls of the flow passage. A heating resistor (6) having a reflective surface that reflects light is provided on the lower inner wall surface. The light reflected by the reflective surface passes through the upper inner wall surface (4) and the observation surface (3).
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: May 3, 2016
    Assignee: Canon Kabushiki Kaisha
    Inventor: Makoto Ogusu
  • Patent number: 9316824
    Abstract: A module for engagement with a conventional microscope to provide selective plane illumination microscopy is disclosed. The module is coupled to the translational base of the microscope and defines a mounting having a mount body in which an excitation objective having a first longitudinal axis is engaged to one portion of the mount body and a detection objective having a second longitudinal axis is engaged to another portion of the mount body such that the first longitudinal axis is in perpendicular geometric relation with the second longitudinal axis.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: April 19, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Hari Shroff, Yicong Wu, Gary Rondeau
  • Patent number: 9291560
    Abstract: An approach for characterizing an optical near field transducer (NFT) involves providing excitation radiation to the NFT. The NFT emits photoluminescent radiation in response to the excitation radiation. The output radiation from the NFT is filtered so that a portion of the photoluminescent radiation emitted by the NFT passes through the filter and the excitation radiation is substantially blocked. A detector detects the portion of photoluminescent radiation and outputs an electrical signal in response to detection of the portion of photoluminescent radiation.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 22, 2016
    Inventors: Chubing Peng, Lifu Zhou
  • Patent number: 9274055
    Abstract: A submersible fluorometer (10), includes: an excitation module (40) for exciting the fluorophore; and a detection module (42) for detecting the light emitted by the excited fluorophore, wherein the excitation module (40) includes a first light source (44) including a first UV LED and having a first wavelength lower than 300 nm, the excitation module (40) includes a second light source (46) including a second UV LED and having a second wavelength lower than 300 nm, the first and second wavelengths being different from each other, and the fluorometer includes an electronic circuit having a plurality of printed circuits positioned one below the other.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: March 1, 2016
    Inventors: Marc Tedetti, Madeleine Goutx
  • Patent number: 9110350
    Abstract: A color conversion filter contains at least one kind of squarylium dye that radiates fluorescence light, has a wavelength conversion capability, absorbs light in an unneeded wavelength region, radiates fluorescence light in a preferable wavelength region, and does not allow decrease in brightness, and thus is preferable for color conversion light-emitting devices, photoelectric conversion devices and the like. Specifically, the color conversion filter has an absorption having a high intensity in the range of 570 to 600 nm, and thus is preferable for use in a color conversion filter that radiates fluorescence light having a high intensity in the range of 600 to 780 nm.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: August 18, 2015
    Inventors: Yosuke Maeda, Koichi Shigeno, Tomoyuki Ariyoshi, Mitsuhiro Okada, Yukiko Kanehara
  • Patent number: 9086273
    Abstract: A LIDAR device may transmit light pulses originating from one or more light sources and may receive reflected light pulses that are detected by one or more detectors. The LIDAR device may include a lens that both (i) collimates the light from the one or more light sources to provide collimated light for transmission into an environment of the LIDAR device and (ii) focuses the reflected light onto the one or more detectors. Each light source may include a respective laser diode and cylindrical lens. The laser diode may emit an uncollimated laser beam that diverges more in a first direction than in a second direction. The cylindrical lens may pre-collimate the uncollimated laser beam in the first direction to provide a partially collimated laser that diverges more in the second direction than in the first direction.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 21, 2015
    Assignee: Google Inc.
    Inventors: Daniel Gruver, Pierre-Yves Droz, Gaetan Pennecot, Zachary Morriss, Dorel Ionut Iordache
  • Patent number: 9068703
    Abstract: The present invention provides a light engine having four light sources. A combination of collimators, bandpass filters, dichroic mirrors, and other elements is operative to direct light from the light sources onto a main optical axis from where it may be focused into a light guide for transport to an instrument or device. Particular embodiments of the invention provide for computer control, intensity control, color control, and light source modulation. Additional embodiments include particular light sources including light pipes and lasers. The light engine provides white light having a high color rendering index and suitable for applications in microscopy, endoscopy, and/or bioanalytical instrumentation.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: June 30, 2015
    Assignee: Lumencor, Inc.
    Inventors: Thomas J. Brukilacchio, Arlie R. Conner
  • Patent number: 8988684
    Abstract: The present disclosure provides a system and a method for measuring fluorescence of a sample. The sample may be a polymerase-chain-reaction (PCR) array, a loop-mediated-isothermal amplification array, etc. LEDs are used to excite the sample, and a photodiode is used to collect the sample's fluorescence. An electronic offset signal is used to reduce the effects of background fluorescence and the noises from the measurement system. An integrator integrates the difference between the output of the photodiode and the electronic offset signal over a given period of time. The resulting integral is then converted into digital domain for further processing and storage.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: March 24, 2015
    Assignee: Lawrence Livermore National Security, LLC
    Inventor: Vincent J. Riot
  • Patent number: 8982344
    Abstract: Technologies are generally described for systems and methods for detecting chiral properties of materials and separating materials based on their chiral properties. A chiral vector is constructed from anisotropy properties of a polarization-dependent output signal from a sample. Different types of molecules from the sample can be differentiated based on a magnitude of the chiral vector. Chiral properties of the sample can be detected based on an angle of the chiral vector. The output signal can be a fluorescent emission from the sample and can be used to detect chiral properties of a substantially opaque sample.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 17, 2015
    Assignee: University of Calcutta
    Inventors: Anjan Kr. Dasgupta, Sarita Roy
  • Patent number: 8970841
    Abstract: An Advanced Laser Fluorometer (ALF) can combine spectrally and temporally resolved measurements of laser-stimulated emission (LSE) for characterization of dissolved and particulate matter, including fluorescence constituents, in liquids. Spectral deconvolution (SDC) analysis of LSE spectral measurements can accurately retrieve information about individual fluorescent bands, such as can be attributed to chlorophyll-a (Chl-a), phycobiliprotein (PBP) pigments, or chromophoric dissolved organic matter (CDOM), among others. Improved physiological assessments of photosynthesizing organisms can use SDC analysis and temporal LSE measurements to assess variable fluorescence corrected for SDC-retrieved background fluorescence. Fluorescence assessments of Chl-a concentration based on LSE spectral measurements can be improved using photo-physiological information from temporal measurements.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: March 3, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Alexander Chekalyuk
  • Patent number: 8937720
    Abstract: A filter wheel and a spectrometer including the filter wheel are disclosed. The filter wheel has a first support structure on which a first plurality of filters are mounted and a second support structure on which at least one filter is provided. A radiation source generates a radiation beam, and a beam splitter splits the radiation beam into a first detection path and a second detection path. The first plurality of filters are selectively movable into the first detection path. The at least one filter on the second support structure is arranged to be disposed in the second detection path. The spectrometer includes a first radiation detector that detects radiation that passes through the selected filter in the first detection path, and a second radiation detector that detects radiation passing through the filter in the second detection path.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: January 20, 2015
    Assignee: Koninklijkle Philips N.V.
    Inventor: James Torrance Russell
  • Publication number: 20150015885
    Abstract: A flame photometric detector assembly can comprise an optics assembly including a focusing mirror adapted to provide a focal region, and a detector block associated with the focusing mirror. The detector block can include a body defining a sampling chamber, a combustion chamber positioned adjacent an outer periphery of the sampling chamber, and a sample column liner adapted to feed sample into the sampling chamber at the focal region.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 15, 2015
    Inventor: Eric Garff
  • Patent number: 8934098
    Abstract: Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: January 13, 2015
    Assignee: Life Technologies Corporation
    Inventors: David Cox, Marc Haberstroh, Patrick Kinney, Albert Carrillo, Jon Hoshizaki, Maryam Shariati, Howard King, Joe Lee, Matthew Chan
  • Patent number: 8892400
    Abstract: With the different methods of fluorescence correlation spectroscopy, physical and biological transport processes in or between cells in the microscopic range, for example diffusion processes, can be analyzed. For this purpose, correlations of the fluorescence measurement data are determined for different sample regions and mathematical transport models are adapted thereto. Erroneous fluorescence correlation analyses were previously identified on the basis of the properties of the adapted model function parameters and were discarded. The a-priori knowledge necessary for the identification had to be obtained in time-consuming series of tests. With the invention, sample properties can be determined in a simpler, quicker and more exact way from fluorescence correlations.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: November 18, 2014
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Stephan Wagner-Conrad, Yauheni Novikau, Klaus Weisshart
  • Patent number: 8891084
    Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices allow light collection from multiple directions. In certain other embodiments, the microfluidic devices use spatial intensity modulation. In certain other embodiments, the microfluidic devices have magnetic field separators. In certain other embodiments, the microfluidic devices have the ability to stack. In certain other embodiments, the microfluidic devices have 3-D hydrodynamic focusing to align sperm cells. In certain other embodiments, the microfluidic devices have acoustic energy couplers. In certain other embodiments, the microfluidic devices have phase variation producing lenses. In certain other embodiments, the microfluidic devices have transmissive and reflective lenses. In certain other embodiments, the microfluidic devices have integrally-formed optics.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: November 18, 2014
    Assignees: Sony Corporation, Sony Corporation of America
    Inventor: Gary P. Durack
  • Patent number: 8885166
    Abstract: An analyzer for biochemical analysis includes a seat for receiving a recipient. A first light source and a second light source illuminate the recipient with a luminous radiation, respectively, in a first excitation band and in a second excitation band, including a first excitation wavelength and a second excitation wavelength of fluorophores of a first type and of a second type. A first image sensor and a second image sensor are oriented so as to receive light emitted by fluorophores contained in the recipient and are, respectively, provided with a first detection filter and a second detection filter, having, respectively, a first detection passband and a second detection passband, including, respectively, a first emission wavelength and a second emission wavelength of the fluorophores of the first type and of the second type.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: November 11, 2014
    Assignee: STMicroelectronics S.R.L.
    Inventors: Marco Angelo Bianchessi, Maria Eloisa Castagna, Federica Guerinoni, Alessandro Cocci
  • Patent number: 8885165
    Abstract: A fluorescence detecting device receives fluorescence emitted by n kinds of measurement objects within wavelength bands FLk (k is an integer of 1 to n) set so that the fluorescence intensity of fluorescence emitted by a measurement object k becomes higher than that of fluorescence emitted by the other one or more measurement objects, and acquires fluorescent signals corresponding to the wavelength bands FLk (k is an integer of 1 to n). Each of the fluorescent signals is subjected to frequency-down conversion by mixing it with a modulation signal for modulating the intensity of a laser beam Lk (k=1) corresponding to at least one of the wavelength bands FLk to produce fluorescence data including the phase delay and intensity amplitude of the fluorescent signal. The fluorescence data is corrected to calculate the phase delay and a fluorescence relaxation time is calculated using the phase delay.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: November 11, 2014
    Assignee: Mitsui Engineering & Shipbuilding Co., Ltd.
    Inventors: Kazuteru Hoshishima, Shigeyuki Nakada
  • Patent number: 8873055
    Abstract: Structures and methods are described for optical detection of physical, chemical and/or biological samples. An optical detection structure may include a LED source, multiple filters and single or multiple sample areas. A detector may be used to record a fluorescence signal. The sample area may allow the introduction of removable cartridges.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: October 28, 2014
    Assignee: California Institute of Technology
    Inventors: Imran R. Malik, Xiomara L. Madero, Erika F. Garcia, Axel Scherer
  • Patent number: 8826519
    Abstract: The present invention relates to a method and system for repairing and refurbishing a microplate reader of the Flipr type which has a water cooled argon laser light source. The old laser is removed and replaced with a high power (300 to 500 mW) air cooled solid state laser as a replacement place on its own support and focused and wired to replace the old laser. The new product operates at lower power consumption yet provides accurate measurements.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: September 9, 2014
    Inventor: Thomas Leen
  • Patent number: 8804216
    Abstract: An image reading device includes a first reader member, an optical system, and a second reader member. The first reader member reads an image recorded on a surface of a medium traveling through a predetermined read area by receiving light from the medium. The read area is set on a transport path along which the medium is transported. The optical system guides the light from the medium to the first reader member. The second reader member has a color measurement unit disposed on an optical path of the light guided by the optical system and performing color measurement on the light. The second reader member reads a color of the image recorded on the surface of the medium on the basis of the light. The second reader member reads a color of an image in a predetermined second area included in the read area read by the first reader member.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: August 12, 2014
    Assignee: Fuji Xerox Co., Ltd.
    Inventor: Masao Ito