Abstract: A chip is constituted from a transparent substrate, a reflector film formed on the transparent substrate and an optical waveguide layer formed on the reflector film, and a plurality of pores is formed in the optical waveguide layer. A light-introducing mechanism that introduces light from the transparent substrate of the chip onto the reflector film, and a light-detecting mechanism that detects the light reflected on the reflector film are provided. A specimen under investigation is detected by sensing a change in the incidence angle or in the intensity of reflected light that occurs when the specimen is adsorbed or deposits on the surface of the optical waveguide layer, by using a range of incidence angles of the light in which the intensity of reflected light changes when a part or all of the incident light couples with the optical waveguide mode that propagates in the optical waveguide layer.
Type:
Grant
Filed:
June 5, 2007
Date of Patent:
October 16, 2012
Assignee:
National Institute of Advanced Industrial Science and Technology
Abstract: A system for the detection of compounds, including a target biological organism or component from a sample, using one or more reactant that will bind to the biological organism or compound forming a Raman active product, concentrating the Raman active product, and detecting the Raman active product using Raman light scattering.
Abstract: A system for identifying a gas sample includes a canister, a docking station, a thermal desorption device, and a spectrometer. The canister includes a sorbent and a valve. The docking station is configured to removably engage the canister. When the canister is engaged with the docking station, the canister is capable of fluid communication with a gas cell via the valve.
Type:
Grant
Filed:
November 15, 2004
Date of Patent:
August 7, 2007
Assignee:
Smiths Detection Inc.
Inventors:
Terence Sauer, Gregg Ressler, Robert Burch, William Desousa, Maxim Frayer, Kenneth Schreiber
Abstract: Apparatus for the manipulating and testing of molecules and in particular of DNA comprising a surface on which the molecule is anchored on multiple points at one end and a paramagnetic bead on which said molecule is anchored on multiple points at its other end, magnetic means for applying a force to the bead, said magnetic means being used to control the stretching and rotation of said bead and molecule, optical magnification means and a camera for the visualisation of said bead, computer means to which the images of the camera are transmitted, said computer means comprising means for analyzing the motions of the bead. A method for the manipulating and testing of molecules and in particular of DNA in which a molecule is anchored at one end to a fixed surface and at its other end to a paramagnetic bead wherein said molecule is anchored on multiple points at each of said ends.
Type:
Grant
Filed:
June 6, 2002
Date of Patent:
May 30, 2006
Assignee:
Center National de la Recherche Scientifique (CNRS)
Inventors:
Terrence R. Strick, Jean F. Allemand, David Bensimon, Aaron Bensimon, Vincent Croquette