Dna Or Rna Pattern Reading Patents (Class 382/129)
  • Patent number: 10156523
    Abstract: A stand-off optical measuring system based on Raman scattering for detecting and identifying chemical threat substances includes a spectrometer having a dispersive device in front of a 2-dimensional detector, with the entrance of the spectrometer being a coded aperture. The measuring system is configured to be able to quickly adapt to different measuring conditions by the coded aperture being a programmable coded aperture.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: December 18, 2018
    Inventors: Markus Nordberg, Henric Oestmark
  • Patent number: 10144966
    Abstract: Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that facilitates sequence analysis. The solid supports and methods provided herein minimize the number of steps required by published sequence analysis methodologies, and thereby offer improved sequence analysis efficiency.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: December 4, 2018
    Assignee: Sequenom, Inc.
    Inventor: Charles R. Cantor
  • Patent number: 10136875
    Abstract: An ultrasonic diagnostic apparatus (100) that decides a type of a tumor contained in a specimen includes: an image forming unit (103) that forms an ultrasonic image corresponding to an echo signal received from the specimen after administration of a contrast medium; a feature value calculating unit (106) that classifies each of a plurality of pixel regions contained in a tumor region including the tumor in the ultrasonic image into a low-luminance region, or a high-luminance region having higher luminance than the luminance of the low-luminance region, and calculates, based on a difference between a variance at a position of the low-luminance region and a variance at a position of the high-luminance region, a ring level indicating a degree of a ring shape of an image of the tumor region, the ring shape in which a luminance value of a central portion is lower than a luminance value of a peripheral portion surrounding the central portion; and a type deciding unit (107) that decides the type of the tumor based o
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: November 27, 2018
    Assignee: Konica Minolta, Inc.
    Inventors: Kazuya Takagi, Satoshi Kondo, Mutsumi Nishida
  • Patent number: 10055438
    Abstract: Embodiments of methods, apparatuses, devices, and/or systems for representing a tree comprising at least a node or at least an edge in the form of signals and/or states, as one or more target numerical signal values substantially in accordance with transformation of the tree to the one or more target numerical signal values based at least in part on an association of trees and numerical signal values are disclosed.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: August 21, 2018
    Assignee: Robert T. and Virginia T. Jenkins
    Inventors: Karl Schiffmann, Jack J. LeTourneau, Mark Andrews
  • Patent number: 9898820
    Abstract: A method for analyzing biological reaction systems is provided. The method includes receiving an image of a substrate including a plurality of reaction sites after a biological reaction has taken place. Next, the method includes removing a noise background from the first image. The method includes determining an initial position of each reaction site based on an intensity threshold to generate a initial position set, then refining the initial position set of each reaction site based on an expected pattern of locations of the plurality of reaction sites to generate a first refined position set. The method further includes determining a presence or absence of a fluorescent emission from each reaction site based on the first refined position set and the first image.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: February 20, 2018
    Assignee: Life Technologies Corporation
    Inventors: Yong Chu, Jeffrey Marks
  • Patent number: 9885652
    Abstract: A multi-well plate reader including an emitter assembly having a plurality of emitters and a receptor assembly including a plurality of receptors separated by at least one spacer element such that a multi-well plate can be inserted between the emitter assembly and the receptor assembly. The emitters and receptors are paired and arranged in parallel arrays such that electromagnetic radiation can be transmitted through each well of the multi-well plate to a corresponding receptor to determine the opacity of the biological material contained within the well. Each well of the multi-well plate can be evaluated by a different emitter receptor pair allowing the entire multi-well plate to be efficiently monitored at a high throughput.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: February 6, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: Jason A. Papin, Paul A. Jensen
  • Patent number: 9843740
    Abstract: A multispectral imaging device includes: an illumination optical system; and an imaging optical system, wherein the illumination optical system includes a filter group disposed in an overlap region of bundles of illumination rays which reach points in an imaging area of a subject, and including at least a first filter and a second filter having different transmission properties, and the imaging optical system includes: an image sensor which includes at least first light receiving elements and second light receiving elements; and a separation optical element which guides light which has passed through the first filter to the first light receiving elements, and guides light which has passed through the second filter to the second light receiving elements.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: December 12, 2017
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventor: Katsuya Nozawa
  • Patent number: 9792531
    Abstract: Intelligent multi-scale image parsing determines the optimal size of each observation by an artificial agent at a given point in time while searching for the anatomical landmark. The artificial agent begins searching image data with a coarse field-of-view and iteratively decreases the field-of-view to locate the anatomical landmark. After searching at a coarse field-of view, the artificial agent increases resolution to a finer field-of-view to analyze context and appearance factors to converge on the anatomical landmark. The artificial agent determines applicable context and appearance factors at each effective scale.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: October 17, 2017
    Assignee: Siemens Healthcare GmbH
    Inventors: Bogdan Georgescu, Florin Cristian Ghesu, Yefeng Zheng, Dominik Neumann, Tommaso Mansi, Dorin Comaniciu, Wen Liu, Shaohua Kevin Zhou
  • Patent number: 9733186
    Abstract: A cell analysis apparatus includes an optical detection section that accommodates a flow of a measurement sample obtained from a biological sample and a pigment into a flow cell. A light source irradiates the measurement sample flowing in the flow cell and a fluorescence detector detects fluorescence from the measurement sample. A signal processing circuit acquires a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal, and a system control section distinguishes between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value of the fluorescence signal obtained by the signal processing circuit.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: August 15, 2017
    Inventors: Masaki Ishisaka, Kazuki Kishi, Masakazu Fukuda
  • Patent number: 9710694
    Abstract: An improved diagnostic resolution of digital slide images is obtained by scanning a first digital slide image at diagnostic resolution that is then deconvolved into separate images with one stain per image. The single stain images are then enhanced with image adjustments and/or processed with image analysis algorithms. The resulting single image data sets from the image analysis algorithms can then be stored. Additionally, the resulting enhanced single images can be recombined into a second digital slide image at diagnostic resolution that is also enhanced.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: July 18, 2017
    Inventors: Dirk G. Soenksen, Cindy Perz
  • Patent number: 9704063
    Abstract: A method of sampling feature points, an image matching method using the same, and an image matching processor are disclosed. The method of sampling feature points for image matching includes: dividing a first image into a plurality of regions corresponding to a number of feature points to be sampled; extracting a sampled feature point from each of the regions such that a distance between a sampled feature point of one region and a sampled feature point of another region satisfies a predetermined condition; and estimating a homography on the basis of the extracted sampled feature points and corresponding sampled feature points of a second image to be matched with the first image.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: July 11, 2017
    Assignee: Hanwha Techwin Co., Ltd.
    Inventors: Jaeyoon Oh, Joonsung Lee, Jaewoo Park
  • Patent number: 9571684
    Abstract: A method for determining a media size of a target scanned on the platen of the flatbed scanner using a fiducial placed on a backer of the flatbed scanner at a predetermined location. The fiducial is comprised of a plurality of objects, either placed in a predetermined pattern or randomly within a fiducial frame. A target is placed on the platen of the flatbed scanner and scanned along with the backer. The scanned image data of the target and backer is searched for the fiducial image. When the fiducial image is found, the media is selected to be of a first target type having a first length, and, when the fiducial is not found the target is selected to be of a second target type have a second length longer than the first length.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: February 14, 2017
    Inventors: Michael Jo Phelps, Mark Lane Mayberry, Edward William Yohon, Jr.
  • Patent number: 9558298
    Abstract: A list of elements in a set of elements is matched by means of regular expressions that define respective groups of elements in the set by approximately matching by means of the regular expressions the list of elements by locating recurrences of the regular expressions in the list of elements with a maximum number of matching errors. The matching errors correspond to insertions deriving from the superposition of groups of elements related to different regular expressions. Each time the recurrence of one regular expression is located in the list, the group of elements defined by the regular expression thus located is removed from the list, while leaving in the list those elements corresponding to errors. The approximate matching can be performed by representing each regular expression in terms of Glushkov automata. The method is applicable, e.g.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: January 31, 2017
    Assignee: Telecom Italia S.p.A.
    Inventors: Danilo Gotta, Daniela Long, Marisa Porta, Giulio Valente
  • Patent number: 9458501
    Abstract: Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an interference pattern generation module that splits a first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: October 4, 2016
    Assignee: Optical Biosystems, Inc.
    Inventors: Stanley S. Hong, Jekwan Ryu, Jong Buhm Park
  • Patent number: 9448228
    Abstract: A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: September 20, 2016
    Inventors: Sunao Takeda, Takahiro Shioyama, Akane Suzuki, Yo Kato, Nae Hinata
  • Patent number: 9359641
    Abstract: In a genome sequencing system and methodology, a protocol is provided to achieve precise alignment and accurate registration of an image of a planar array of nanoballs subject to optical analysis. Precise alignment correcting for fractional offsets is achieved by correcting for errors in subperiod x-y offset, scale and rotation by use of minimization techniques and Moiré averaging. In Moiré averaging, magnification is intentionally set so that the pixel period of the imaging element is a noninteger multiple of the site period. Accurate registration is achieved by providing for pre-defined pseudo-random sets of sites, herein deletion or reserved sites, where nanoballs are prevented from attachment to the substrate so that the sites of the array can be used in a pattern matching scheme as registration markers for absolute location identification.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: June 7, 2016
    Inventor: Bryan P. Staker
  • Patent number: 9275448
    Abstract: Provided are methods and systems for generating a binarized representation of a document using a mobile device configured to provide a Flashed and No-flashed image of the document. According to an exemplary method, the Flash and No-flash images are aligned and blended, where the resulting image includes the No-flash image where any hot spots are included in the Flash image. After blending, the blended image is binarized.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: March 1, 2016
    Assignee: Xerox Corporation
    Inventors: Martin S. Maltz, Raja Bala, Phillip J. Emmett
  • Patent number: 9221056
    Abstract: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one aspect, the present invention provides a method for controlling the temperature of a heater electrode associated with a microfluidic channel of a microfluidic device, wherein power applied to the heater electrode is regulated by varying the duty cycle of a pulse width modulation (PWM). In another aspect, the present invention a controller configured to compute the temperature of the heater electrode during the power-on portion of the duty cycle and the during the power-off portion of the duty cycle and to adjust the duty cycle as necessary to achieve a desired temperature in the heater electrode.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: December 29, 2015
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Gregory H. Owen, Gregory A. Dale, Kenton C. Hasson
  • Patent number: 9172939
    Abstract: A system and method for adjusting the perceived depth of stereoscopic images are provided. The system includes a disparity estimator, a disparity processor and a warping engine. The disparity estimator is configured to receive a stereoscopic image, to estimate disparities in the stereoscopic image, and to generate an estimator signal comprising the estimated disparities. The disparity processor is configured to receive the estimator signal from the disparity estimator and a depth control signal that is generated based on a user input. The disparity processor is also configured to generate a processor signal based on the estimator signal and the depth control signal. The warping engine is configured to receive the processor signal and to generate an adjusted stereoscopic image by warping the processor signal based on a model.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: October 27, 2015
    Assignee: STMicroelectronics (CANADA), Inc.
    Inventor: Eduardo R. Corral-Soto
  • Patent number: 9122904
    Abstract: Embodiments of the present invention are directed to a method for determining an amount of a plurality of molecular species in a sample, each molecular specie being indicated by a dye. According to one embodiment, the amount of a plurality of molecular species is determined by acquiring a plurality of images of the sample, determining an amount of each molecular specie, as indicated by a respective dye, for each pixel at each corresponding pixel location in the plurality of images, and refining the amount of a plurality of molecular species at one or more pixel locations in the plurality of images. Associated systems and computer program products are also provided.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: September 1, 2015
    Assignee: TriPath Imaging, Inc.
    Inventors: Raphael Rodolphe Marcelpoil, Cedrick Rene Orny
  • Patent number: 9117024
    Abstract: Systems, methods, and apparatus are described for the handling of biological specimens for analysis. The systems, methods and apparatus are designed to reduce errors in misidentification, incorrect processing, and recordkeeping and reporting. The systems, methods, and apparatus can also provide real time tracking of samples at any stage, from collection to processing to analyzing to storage.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: August 25, 2015
    Assignee: Dako Denmark A/S
    Inventor: Jose De La Torre-Bueno
  • Patent number: 9057701
    Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: June 16, 2015
    Inventors: Peter Ramm, Yuriy Alexandrov, Paul Donders, Carlos Zarate, Bohdan J. Soltys
  • Publication number: 20150140562
    Abstract: An optical analyzer, configured to receiving a cartridge for biochemical analyses including a plurality of wells, and carrying out fluorescence analysis of the cartridge, in particular of the wells. The analyzer comprises a control unit (microprocessor and memory) configured to: (a) acquiring an image associated to the fluorescence emitted by the cartridge; (b) identifying, in the image, pixels belonging to boundary lines of the wells by generating a black and white binary image; (c) recognizing, between the geometrical shapes identified in step (b), the ones that best approximate a reference geometrical shape identifying an ideal well; (d) acquiring, from the starting image, values of light intensity only in portions of the image itself that in turn correspond to the regions recognized in step (c); and (e) evaluating a state of advance and/or a result of the biochemical analysis on the basis of the values of light intensity acquired in step (d).
    Type: Application
    Filed: November 17, 2014
    Publication date: May 21, 2015
    Inventors: Sabrina CONOCI, Maria Eloisa CASTAGNA, Massimo Orazio SPATA, Dario RUSSO
  • Patent number: 9036899
    Abstract: A method and system for volumetric quantification of local bone changes includes the steps of loading at least a first and second (cone-beam) computed tomography three dimensional image, registering the first three dimensional image and second three dimensional image to one coordinate system, selecting a region of interest in one of the first three dimensional image or the second three dimensional image.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: May 19, 2015
    Inventor: Bart Vandenberghe
  • Patent number: 9031295
    Abstract: An angiographic method is provided. The method includes: identification of a relevant part in acquired angiography 4D sequences which exhibit a vascular disorder or change; determination of a centerline for the part; ascertainment of lines parallel and surrounding the centerline; specification of perpendicular cross-sections; determination of voxels; ascertainment of bolus curves as a function of time for each voxel; which intersects one of the cross-sections; determination of a time for each voxel; measurement of the true Euclidean distance between voxels at the positions along the centerline and the parallel lines; division of the measured distance by the time difference; determination of second speed components, running transversely, proportional to the relative change in mass for each voxel; and calculation of the blood flow in the relevant part of the vascular system on the basis of the speed components.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: May 12, 2015
    Assignee: Siemens Aktiengesellschaft
    Inventor: Klaus Klingenbeck
  • Publication number: 20150125053
    Abstract: A method of registering features in a repeating pattern can include (a) providing an object having a repeating pattern of features and a fiducial; (b) obtaining a target image of the object, wherein the target image includes the repeating pattern of features and the fiducial; (c) comparing the fiducial in the target image to reference data, wherein the reference data includes xy coordinates for a virtual fiducial; and (d) determining locations for the features in the target image based on the comparison of the virtual fiducial in the reference data to the fiducial in the data from the target image. The fiducial can have at least concentric circles that produce three different signal levels. The locations of the features can be determined at a variance of less than 5 ?m.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 7, 2015
    Applicant: Illumina, Inc.
    Inventors: John S. Vieceli, Stephen Tanner, John A. Moon, M. Shane Bowen
  • Patent number: 9020223
    Abstract: The invention relates to a method for non-invasive reproducible determination of a corrected surface on a 3D bone surface model constructed from 3D medical image of a bone having a deformation consisting in a bump overgrowth at the head-neck junction; wherein said corrected surface comprises: i) a 3D spherical corrected surface patch on the head portion of said 3D bone surface model, and ii) a 3D smooth transition corrected surface patch on the neck portion of said 3D bone surface model, contiguous to said 3D spherical corrected surface patch; Said corrected surface patches are defined by a set of parameters comprising: iii) at least one first parameter (a*) representing a spherical extent value of said 3D spherical corrected surface patch, iv) and a set of at least one second parameter, said set determining the 3D correction boundary of said corrected surface patches, such that said corrected surface patches are continuous with said 3D bone surface model along said boundary.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: April 28, 2015
    Assignee: A2 Surgical
    Inventors: Laurence Chabanas, Stéphane Lavallee, Jerome Tonetti, Thomas Byrd, Bryan Talmadge Kelly, Christopher Larson
  • Patent number: 9020222
    Abstract: An arrangement for computer-assisted structuring of medical examination data is provided. The arrangement has a device for receiving at least one medical examination data record including at least one image data record created with a radiological imaging device, a device for receiving medical video data from external video sources, a device for converting the medical video data into a medical standard format in which a time stamp of the video data generation is stored, a device for storing the converted video data and the at least one examination data record, and a device for outputting the video data and examination data record. The video data and the at least one image data record can be arranged according to their time stamp.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: April 28, 2015
    Assignee: Siemens Aktiengesellschaft
    Inventor: Michael Wiets
  • Patent number: 9020221
    Abstract: Certain aspects of an apparatus and method for automatic ER/PR scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying a positive stained nucleus in a slide image of the tissue sample, identifying a negative stained nucleus in the slide image, computing a proportion score based on number of the positive stained nucleus identified and number of the negative stained nucleus identified and determining the cancer diagnosis score based on the proportion.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: April 28, 2015
    Assignee: Sony Corporation
    Inventors: Ming-Chang Liu, Ximin Zhang
  • Patent number: 9020220
    Abstract: An X-ray CT apparatus is provided. The X-ray CT apparatus includes an estimation device configured to estimate a feature quantity that relates to one of image quality and a pixel value of an image obtained by performing an X-ray CT scan on a imaging target under a predetermined scan condition, wherein the feature quantity has a correlative relationship with a dose that is based on data obtained from X-ray imaging performed on the imaging target before a main scan, and a calculation device configured to calculate a dose for the imaging target for a case when an X-ray CT scan is performed under a desired setup scan condition, the dose calculated based on the estimated feature quantity and the correlative relationship between feature quantity and dose.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: April 28, 2015
    Assignee: GE Medical Systems Global Technology Company, LLC
    Inventor: Masatake Nukui
  • Publication number: 20150098637
    Abstract: The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data.
    Type: Application
    Filed: November 21, 2014
    Publication date: April 9, 2015
    Inventor: Earl A. HUBBELL
  • Patent number: 9002084
    Abstract: A system includes a detector and a processing module. The detector includes pixels configured to detect an event corresponding to energy from a radiopharmaceutical. The processing module is configured to receive a request for each pixel that detects energy during a reading cycle. The processing module is configured to determine an energy level for each requesting pixel. For each requesting pixel, the processing module is configured to count the event when the energy level corresponds to an energy of the radiopharmaceutical, and to determine a combined energy level of the pixel and at least one adjacent pixel when the energy level does not correspond. The processing module is configured to count the event when the combined energy level corresponds to the energy of the radiopharmaceutical, and to disregard the event when the combined energy level does not correspond to the energy of the radiopharmaceutical.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: April 7, 2015
    Assignee: GE Medical Systems Israel, Ltd
    Inventors: Arie Shahar, Eliezer Traub, Peter Rusian, Yaron Glazer, Danny Magal, Zeev Gerber
  • Patent number: 8989466
    Abstract: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: March 24, 2015
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Kenton C. Hasson, Gregory A. Dale, John P Keady
  • Patent number: 8977020
    Abstract: An image processing device 100 divides a hollow organ 50 extracted from a volume image 40 using a plurality of planes 20 including an arbitrary eye vector 23 or a plurality of planes along the centerline of the hollow organ 50, transforms the coordinates of a point inside the hollow organ 50 along a predetermined convex surface set outside the hollow organ 50 on each plane 20, and gives a pixel value of an original position to a corresponding point after the coordinate transformation. Then, a folded volume image is generated by combining the respective planes 20 in a reverse procedure of the division procedure, and a shaded folded three-dimensional image 90 is generated by projecting the folded volume image to a projection surface from the arbitrary viewing direction and is displayed on a display device 107.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: March 10, 2015
    Assignee: Hitachi Medical Corporation
    Inventor: Yoshihiro Goto
  • Publication number: 20150063666
    Abstract: Disclosed are systems and methods for assessing images in applications such as microscopic scanning of a slide having light emitting objects. In certain embodiments, such scanning can involve objects such as sequencing beads disposed on the slide to facilitate biological analysis such as nucleic acid sequencing. Also disclosed are certain embodiments where images of light emitting objects are assessed for image quality so as to facilitate a feedback response such as a corrective action. In certain embodiments, such assessment and correction can be performed in real-time during the scanning process, and can include re-acquisition of the assessed image. Also disclosed are certain embodiments where such assessment and correction can be triggered dynamically during the scan, or before start of the scan, so as to enhance the scanning performance, including scanning time and throughput.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 5, 2015
    Inventor: Haoning FU
  • Patent number: 8965076
    Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: February 24, 2015
    Assignee: Illumina, Inc.
    Inventors: Francisco Garcia, Klaus Maisinger, Stephen Tanner, John Moon, Tobias Mann, Michael Lawrence Parkinson, Anthony James Cox, Haifang H. Ge
  • Patent number: 8934689
    Abstract: The invention provides methods and systems for reconstructing feature intensities from pixel level data. In certain embodiments, the invention uses an empirically determined transfer function to construct a theoretical estimate of pixel level data and then iteratively updates feature intensities based on a minimum multiplicative error between the pixel level data and the theoretical estimate of the pixel level data.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: January 13, 2015
    Assignee: Affymetrix, Inc.
    Inventor: Earl A. Hubbell
  • Patent number: 8929630
    Abstract: Disclosed are systems and methods for assessing images in applications such as microscopic scanning of a slide having light emitting objects. In certain embodiments, such scanning can involve objects such as sequencing beads disposed on the slide to facilitate biological analysis such as nucleic acid sequencing. Also disclosed are certain embodiments where images of light emitting objects are assessed for image quality so as to facilitate a feedback response such as a corrective action. In certain embodiments, such assessment and correction can be performed in real-time during the scanning process, and can include re-acquisition of the assessed image. Also disclosed are certain embodiments where such assessment and correction can be triggered dynamically during the scan, or before start of the scan, so as to enhance the scanning performance, including scanning time and throughput.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: January 6, 2015
    Assignee: Life Technologies Corporation
    Inventor: Haoning Fu
  • Patent number: 8922342
    Abstract: Systems, apparatus, and methods for continuously authenticating individuals are provided. A continuous authentication system receives first biometric authentication information from an individual. The system compares the first biometric authentication information to stored first biometric information to identify the individual and links the identified individual to a device for obtaining second biometric authentication information. The device for obtaining second biometric authentication information continuously receives second biometric authentication information. The continuous authentication system compares the received second biometric authentication information to stored second biometric information that corresponds to the individual to determine if the received second biometric authentication information corresponds to the individual.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: December 30, 2014
    Assignee: Noblis, Inc.
    Inventors: Timothy Patrick Ashenfelter, George Ihor Kiebuzinski, John R. Mercier, Matthew K. Monaco, Lawrence Dennis Nadel, Jonathan Mark Phillips, Daniel Farlow Uyesugi
  • Publication number: 20140369579
    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.
    Type: Application
    Filed: March 10, 2014
    Publication date: December 18, 2014
    Applicant: Bioarray Solutions, Ltd.
    Inventors: Michael Seul, Xiongwu Xia, Chiu Chau, Scott Determan
  • Patent number: 8891851
    Abstract: A home healthcare management system wherein a patient conducts self diagnoses and self testing, and manages their own medical records at home. A digital microscope is utilized as part of the system that is smaller, of lower cost, faster, of a higher dynamic range, and has a higher resolution than conventional microscopes. The microscope consists of an illumination source, a spatial sub-sampling device and a detector device. The digital microscope provides a vectored method of collecting images from a digital microscope that is independent of the optical resolution, and a slide based coordinate system, and a method of displaying images and communicating such images over the Internet in a file format that does not require a header or prior knowledge of magnification, coordinate system, or tiling structure. The system further includes an interface for physiological monitoring devices and a connection to the Internet for more comprehensive services.
    Type: Grant
    Filed: July 13, 2010
    Date of Patent: November 18, 2014
    Inventor: Glenn F. Spaulding
  • Patent number: 8879801
    Abstract: Systems and methods for tracking a head position of a user include obtaining digital images of the user's head, processing the images to locate anatomical structures beneath the visible surface, and using those determined locations as inputs to a computing device. In an embodiment, images of a user's face are processed to identify the irises of the eyes, identify pixels along a boundary between each iris and the surrounding sclera, determine an ellipse defined by the identified iris-sclera boundary pixels, determine a distance-to-pixel ratio based on a pixel length of a long axis of such an ellipse compared to a known or presumed diameter of the iris, locating the iris in a three-axis coordinate system, determining an optical axis vector of the eye in the three-axis coordinate system, and calculating a center of the eyeball based on the optical axis vector and a known or presumed eyeball radius.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: November 4, 2014
    Assignee: QUALCOMM Incorporated
    Inventor: Richard R. Ragland
  • Patent number: 8848997
    Abstract: In a medical image acquisition, and operating method, before acquiring a current planning image data set from a subject, a statistical atlas is generated from multiple planning image data sets using a specific measurement protocol, as a statistical compilation including an average image data set electronically associated with association information that identifies different anatomical entities represented by the statistical compilation. After the current planning image data set is acquired, the stored average image data set is transformed into the current planning image data set, with the association information being accurately associated with the current planning image data set. A diagnostic image acquisition of the subject is then controlled using the association information that is now associated with the current planning image data set.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: September 30, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Matthias Fenchel, Andreas Schilling, Stefan Thesen
  • Publication number: 20140270435
    Abstract: Methods, articles and systems that provide imagewise mapping or display of gene expression of a biosample, by contacting the biosample, such as a tissue slice or metacommunity, to a detector which captures material from the biosample and processes the captured material. In one embodiment the detector has an array of one or more capture sites at defined positions on the detector, each site carrying an immobilized capture oligonucleotide and a site-indexing oligonucleotide. The array captures mRNA from the biosample contacted thereto, and the captured mRNA is processed to form a sequenceable amount of amplified captured material which includes the site-indexing oligonucleotide, so that when sequenced, detection of the site-indexing oligonucleotide indicates the original capture location on the array, thereby mapping the sequenced material to its capture location and imaging display of gene expression distribution in the original biosample.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Inventor: Casey DUNN
  • Patent number: 8831316
    Abstract: The invention provides a technique for accurate detection of objects appearing in the image, such as single fluorescent molecules, cells, microorganisms, nucleotides, DNA strands, or stars in celestial images. The method allows to differentiate between two combined point sources even if they are closer to each other than the optical resolution of the system. The procedure involves computing several coefficients representing decomposition of the intensity data in the basis of Hermit functions.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: September 9, 2014
    Assignee: Anastasia Tyurina
    Inventor: Anastasia Tyurina
  • Patent number: 8831305
    Abstract: Pseudo dual-energy material identification systems and methods with under-sampling are disclosed. The system comprises a ray generating device, a mechanic rotation control section, a data collecting subsystem comprising a first tier of detectors and a second tier of detectors, and a master control and data processing computer. The system utilizes a CT-imaging-based material identification method with under-sampled dual-energy projection data, in which only a few detectors at the second tier are used to perform dual-energy projection data sampling, and optimization is made on the procedure of solving an equation system.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: September 9, 2014
    Assignees: Tsinghua University, Nuctech Company Limited
    Inventors: Li Zhang, Zhiqiang Chen, Yuanyuan Liu, Yuxiang Xing, Ziran Zhao
  • Patent number: 8832139
    Abstract: A method for searching a database (206) with stored information using parallel searching of superposition representations of the information. In one approach, the method involves searching a target DNA or RNA genome (16) sequence to determine whether a match is present between a sequence probe and the target. The method includes encoding the target sequence as superpositions of wavefunctions, encoding the probe as one or more wavefunctions, and comparing the encoded target with the encoded probe. The encoding of the target may involve applying a transform (e.g., discrete Fourier transform) to the target sequence to obtain the wavefunctions used to form the one or more superposition representations.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: September 9, 2014
    Inventor: Roger Selly
  • Patent number: 8818058
    Abstract: A method of correcting target region in computed tomographic (CT) image, including the steps of obtaining a CT image of a patient; determining the size of a target object in the CT image; and correcting CT numbers of a portion of the CT image that corresponds to the target object, based on the determined size of the target object.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: August 26, 2014
    Assignees: Toshiba Medical Systems Corporation, University Health Network
    Inventors: Narinder S. Paul, Ali Ursani, Joerg Blobel
  • Publication number: 20140233816
    Abstract: A method for improving image quality is provided. The method includes receiving image data of a substrate, wherein the image data is generated by imaging the substrate, and an image is generated from the image data. The method further includes generating a background representation from a background noise portion of the image, wherein the background portion includes signal information undesired for further processing and generating a background subtracted image by subtracting the background rep resentation from the image. In this way, a separate background image is not needed to subtract the background from the image including the regions-of-interest to improve image quality.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 21, 2014
    Inventors: Francis T. Cheng, Thomas Wessel
  • Patent number: 8811704
    Abstract: The disclosed systems and methods allow composite images with enhanced dynamic range to be generated that result in more accurate, reliable, and efficient chemical and/or biological analyses. The disclosed systems include an image detector; a timer for tracking exposure time of the image detector; and computer readable medium, including instructions that when executed cause a computer system to generate a composite image using the multiple images of pixels.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: August 19, 2014
    Assignee: Aushon Biosystems, Inc.
    Inventors: Peter Honkanen, Scott Douglas, Ralph H. Jung, Jr.