Deuterium-containing Patents (Class 423/647.7)
  • Patent number: 10940437
    Abstract: A liquid phase catalytic exchange column with a catalyst is configured to receive hydrogen gas. The system uses the catalyst to exchange the hydrogen gas with the tritiated source yielding HT gas and tritiated water. The system monitors tritium content of the tritiated water. When a predetermined tritium level is detected, the tritiated water is released. The system also includes a gaseous permeation system comprising a permeable barrier for the selective extraction of gases.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: March 9, 2021
    Assignee: Veolia Nuclear Solutions, Inc.
    Inventors: Mark S. Denton, Gaetan Bonhomme, Wesley L. Bratton, Nicephore Bonnet
  • Patent number: 9455056
    Abstract: A method of collecting 3He from a nuclear reactor may include the steps of a) providing heavy water at least part of which is exposed to a neutron flux of the reactor, b) providing a cover gas in fluid communication with the heavy water, c) operating the nuclear reactor whereby thermal neutron activation of deuterium in the heavy water produces tritium (3H) and at least some of the tritium produces 3He gas by ?? decay and at least a portion of the 3He gas escapes from the heavy water and mixes with the cover gas, d) extracting an outlet gas stream, the outlet gas stream comprising a mixture of the cover gas and the 3He gas and e) separating the 3He gas from the outlet gas stream.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: September 27, 2016
    Assignee: Atomic Energy of Canada Limited/Énergie Atomique du Canada Limitée
    Inventors: Bhaskar Sur, Lakshman Rodrigo, Richard Didsbury
  • Publication number: 20150034500
    Abstract: A metal organic framework (MOF) includes a coordination product of a metal ion and an at least bidentate organic ligand, where the metal ion and the organic ligand are selected to provide a deliverable adsorption capacity of at least 70 g/l for an electronic gas. A porous organic polymer (POP) includes polymerization product from at least a plurality of organic monomers, where the organic monomers are selected to provide a deliverable adsorption capacity of at least 70 g/l for an electronic gas.
    Type: Application
    Filed: August 4, 2014
    Publication date: February 5, 2015
    Inventors: Han Sung KIM, Mitchell Hugh WESTON, Patrick FULLER, Paul Wai-Man SIU
  • Publication number: 20150025264
    Abstract: Objects are to provide efficient methods for producing hydrogen or heavy hydrogens and for hydrogenating (protiating, deuterating or tritiating) an organic compound, and to provide an equipment and the like used therefor. A method for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, in which an energy density of a rotational acceleration of 75 G or more is applied to water or heavy water for 25 minutes or more, a method for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, a method for hydrogenating (protiating, deuterating or tritiating) an organic compound, a method for dehalogenating an organic compound having halogen, and a ball for mechanochemical reaction are provided.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 22, 2015
    Applicant: Shiono Chemical Co., Ltd.
    Inventors: Hironao Sajiki, Yasunari Monguchi, Yoshinari Sawama, Shinichi Kondo, Yasushi Sasai
  • Publication number: 20140363369
    Abstract: An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 11, 2014
    Applicant: Shiono Chemical Co., Ltd.
    Inventors: Hironao SAJIKI, Yasunari MONGUCHI, Yoshinari SAWAMA, Shinichi KONDO
  • Patent number: 8801963
    Abstract: The present invention relates to a process for the preparation of stannane and deuterostannane by reacting a stannic halide with lithium aluminum hydride or aluminum deuteride respectively in a polydentate solvent.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: August 12, 2014
    Assignee: Voltaix, LLC
    Inventor: Cole J. Ritter, III
  • Publication number: 20140099252
    Abstract: An approach for supplying hydrogen and/or deuterium to LENR and E-Cat based energy generating systems includes receiving a source material that is rich in hydrogen and/or deuterium. A gaseous form of at least one of those elements is extracted from the source material via electrochemical dissociation, hydrocarbon recovery, or a suitable mechanical process. The gaseous form of the element is preferably filtered to remove water vapor and other impurities before being pressurized and supplied to the energy generating system. Advantages of the approach include enhanced safety and system portability due to elimination of a need for pressurized gas storage tanks.
    Type: Application
    Filed: October 9, 2012
    Publication date: April 10, 2014
    Inventors: Marc Kenneth Chason, Daniel Roman Gamota, Rick Latella
  • Patent number: 8592487
    Abstract: This invention relates to novel compounds that are hydroxyethylamino sulfonamide derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel hydroxyethylamino sulfonamide derivatives that are derivatives of darunavir. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering a human immunodeficiency virus (HIV) protease inhibitor, such as darunavir.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: November 26, 2013
    Assignee: Concert Pharmaceuticals, Inc.
    Inventor: Scott L. Harbeson
  • Patent number: 8470073
    Abstract: The apparatus and process for separating hydrogen isotopes is provided using dual columns, each column having an opposite hydrogen isotopic effect such that when a hydrogen isotope mixture feedstock is cycled between the two respective columns, two different hydrogen isotopes are separated from the feedstock.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: June 25, 2013
    Assignee: Savannah River Nuclear Solutions, LLC
    Inventors: Leung K. Heung, Henry T. Sessions, Xin Xiao
  • Patent number: 8440165
    Abstract: A method includes operating a gas loading system with a source of one or more isotopes of hydrogen, a gas loading chamber containing a number of metallic nanoparticles, the metallic nanoparticles being selected to provide for a predetermined hydrogen cluster formation density, a vacuum system, and a valve system in communication with the gas loading chamber, the source of one or more isotopes of hydrogen and the vacuum system; providing the gas loading chamber with a first quantity of the one or more isotopes of hydrogen from the source of one or more isotopes of hydrogen; monitoring an operating temperature; and cycling a loading pressure of the gas loading chamber using the source of one or more isotopes of hydrogen in response to providing the gas loading chamber and monitoring the operating temperature.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: May 14, 2013
    Assignee: NPL Associates, Inc.
    Inventors: George H. Miley, Xiaoling Yang
  • Patent number: 8313726
    Abstract: A gas generator includes a processing vessel defining a processing space and holding a support body therein, an evacuation system evacuating the processing space; a metal oxide film of a perovskite structure containing oxygen defects formed on the support body, a source gas supplying port supplying a source gas containing molecules of a source compound of carbon dioxide or water into the processing space, a gas outlet port for extracting a product gas containing molecules of a product compound in which oxygen atoms are removed from said source compound, and a heating part heating the support body.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: November 20, 2012
    Assignee: Fujitsu Limited
    Inventors: John David Baniecki, Masatoshi Ishii, Kazuaki Kurihara, Kazunori Yamanaka
  • Publication number: 20120164063
    Abstract: A method includes operating a gas loading system with a source of one or more isotopes of hydrogen, a gas loading chamber containing a number of metallic nanoparticles, the metallic nanoparticles being selected to provide for a predetermined hydrogen cluster formation density, a vacuum system, and a valve system in communication with the gas loading chamber, the source of one or more isotopes of hydrogen and the vacuum system; providing the gas loading chamber with a first quantity of the one or more isotopes of hydrogen from the source of one or more isotopes of hydrogen; monitoring an operating temperature; and cycling a loading pressure of the gas loading chamber using the source of one or more isotopes of hydrogen in response to providing the gas loading chamber and monitoring the operating temperature.
    Type: Application
    Filed: March 7, 2012
    Publication date: June 28, 2012
    Inventors: George H. Miley, Xiaoling Yang
  • Patent number: 7815890
    Abstract: A diffusion based process for tritium removal from water by tritium transfer from water to an elemental hydrogen stream, followed by a membrane diffusion cascade for tritium stripping and enrichment, and final tritium enrichment by one or more thermal diffusion columns. The combination of process steps takes advantage of membrane diffusion's large throughput capability at low tritium concentration with the simplicity of thermal diffusion for small throughput final tritium enrichment. The membrane diffusion stages use supported or unsupported microporous or hydrogen permeable metal membranes (such as Pd/Ag alloy). The diffusion process is compatible with any front-end process to transfer tritium from tritiated water to elemental hydrogen. The process may be designed and operated at low pressure, with small gas inventory, and no inherent overpressure hazard.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: October 19, 2010
    Assignee: Special Separations Application, Inc.
    Inventor: Anthony Busigin
  • Patent number: 7745665
    Abstract: Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 3, 2008
    Date of Patent: June 29, 2010
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • Publication number: 20090130016
    Abstract: Provided is a thermionic cathode doped with an increased binding energy hydrogen species and a method of making the doped thermionic cathode.
    Type: Application
    Filed: May 21, 2008
    Publication date: May 21, 2009
    Inventor: Randell L. Mills
  • Publication number: 20080299219
    Abstract: The present application describes deuterium-enriched oxybutynin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 4, 2008
    Applicant: PROTIA, LLC
    Inventor: Anthony W. Czarnik
  • Publication number: 20080299215
    Abstract: The present application describes deuterium-enriched lestaurtinib, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: May 29, 2007
    Publication date: December 4, 2008
    Applicant: PROTIA, LLC
    Inventor: Anthony W. Czarnik
  • Publication number: 20080299217
    Abstract: The present application describes deuterium-enriched bifeprunox, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 4, 2008
    Applicant: PROTIA, LLC
    Inventor: Anthony W. Czarnik
  • Publication number: 20080299216
    Abstract: The present application describes deuterium-enriched aripiprazole, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 4, 2008
    Applicant: PROTIA, LLC
    Inventor: Anthony W. Czarnik
  • Publication number: 20080299218
    Abstract: The present application describes deuterium-enriched valsartan, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 4, 2008
    Applicant: PROTIA, LLC
    Inventor: Anthony W. Czarnik
  • Publication number: 20080145303
    Abstract: [PROBLEMS] To provide a method for producing heavy hydrogen gas, which enables heavy hydrogen gas to be efficiently produced from a deuterated solvent as a reaction substrate. [MEANS FOR SOLVING PROBLEMS] (1) A method for producing heavy hydrogen gas, comprising bringing a deuterated solvent into contact with hydrogen gas under pressure in the coexistence with a catalyst selected from a palladium catalyst, a platinum catalyst, a nickel catalyst, a cobalt catalyst, an iridium catalyst, and a rhodium catalyst and a ruthenium catalyst which are not coordinated with a ligand, and (2) a catalytic deuteration method of a compound having a reducible functional group, comprising bringing the heavy hydrogen gas obtained by the above (1) into contact with the compound having a reducible functional group in the coexistence with a catalytic reduction catalyst.
    Type: Application
    Filed: January 16, 2006
    Publication date: June 19, 2008
    Applicant: WAKO PURE CHEMICAL INDUSSRIES, LTD.
    Inventors: Kosaku Hirota, Hironao Sajiki, Nobuhiro Ito
  • Patent number: 7153486
    Abstract: A method to catalyze hydrogen isotope exchange between water and hydrogen in which the water and hydrogen are contacted with a wetproofed catalyst, the catalyst having a hydrophobic porous matrix which has dispersed therein catalytically active platinum and at least one other metal which is chromium or titanium.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: December 26, 2006
    Assignees: Atomic Energy of Canada Limited, Energie Atomique Du Canada Limitee
    Inventors: Jintong Li, Sam Suppiah, Keith Kutchcoskie
  • Patent number: 7033568
    Abstract: A palladium hydride superconductor, PdyHx where yHx is 1Hx, 2Hx, or 3Hx, having a critical temperature Tc?11K and stoichiometric ratio x?1. The critical temperature is proportional to a power of the stoichiometric ratio, which is stable over periods exceeding 24 hours, temperature variations from 4K to 400K, and pressures down to 1 mbar. The palladium hydride is coated with a stabilizing material such as a metal, metal oxide, ceramic, or polymer that can bond to palladium. It can be made by electrochemically loading a palladium lattice with isotopic hydrogen in an electrolytic solution, by allowing isotopic hydrogen to diffuse into a palladium thin film in a pressure chamber, or by injecting isotopic hydrogen into a palladium thin film in a vacuum chamber. The stabilizing material can be electrochemically bonded to the surface of the palladium hydride, or deposited using chemical vapor deposition or molecular beam epitaxy.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: April 25, 2006
    Inventor: Paolo Tripodi
  • Patent number: 6221331
    Abstract: A synthetic route for forming lithium trisubstituted borohydride compounds comprises the step of reacting a processed lithium hydride reactant with a trisubstituted borane wherein the reaction is maintained for a period of time in a temperature range of approximately 15° C. to approximately 42° C. A method of synthesizing LiH comprises the step of reacting an alkyl lithium (for example, n-butyl lithium) with hydrogen in the presence of tetrahydrofuran. The reaction temperature is preferably maintained in the range of approximately −78° C. to approximately 25° C.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: April 24, 2001
    Assignee: Mine Safety Appliances Company
    Inventors: Elizabeth R. Burkhardt, Christopher P. Sutton, Joerg Bruening, David F. Rouda