Coated, Impregnated, Or Colloidal Particulate (e.g., Microcapsule, Micro-sphere, Micro-aggregate, Macro-aggregate) Patents (Class 424/1.29)
-
Publication number: 20100111850Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: March 27, 2009Publication date: May 6, 2010Inventors: Edward S. Boyden, Daniel B. Cook, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
-
Publication number: 20100111841Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: October 31, 2008Publication date: May 6, 2010Inventors: Edward S. Boyden, Daniel B. Cook, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
-
Publication number: 20100111847Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: March 27, 2009Publication date: May 6, 2010Inventors: Edward S. Boyden, Daniel B. Cook, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
-
Publication number: 20100111845Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: October 31, 2008Publication date: May 6, 2010Inventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
-
Publication number: 20100111849Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: March 27, 2009Publication date: May 6, 2010Inventors: Edward S. Boyden, Daniel B. Cook, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
-
Publication number: 20100111844Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: ApplicationFiled: October 31, 2008Publication date: May 6, 2010Inventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, JR.
-
Publication number: 20100092384Abstract: Provided is a multifunctional particle comprising: (a) an inner metallic core, (b) a biocompatible shell comprising an optical contrast agent embedded therein, and (c) a targeting biomolecule conjugated to the biocompatible shell through a multidentate ligand, wherein the multidentate ligand is chelated to an imaging agent. Also provided are compositions comprising the multifunctional particle and methods of using the multifunctional particle, including a method of diagnostic imaging and a method of treatment.Type: ApplicationFiled: March 17, 2008Publication date: April 15, 2010Applicants: The jUnited States of America as represented by Secretary, Dept. of Health and Human Service, University of OxfordInventors: Ambika Bumb, Martin W. Brechbiel, Peter Choyke, Lars Fugger, Peter James Dobson
-
Publication number: 20100047163Abstract: The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so s to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of c incorporating and targeting therapeutics for diseases associated with the expression of the LDL receptor. The invention further provides methods of using such synthetic LDL nanoparticles.Type: ApplicationFiled: November 13, 2006Publication date: February 25, 2010Applicants: LAWRENCE BERKELEY NATIONAL LABORATORY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CHILDREN'S HOSPITAL & RESEARCH CENTER OAKLANDInventors: Trudy M. Forte, Mina Nikanjam
-
Publication number: 20100034735Abstract: The invention provides modified gold nanoparticles that enable a non-invasive, real time, targeted cancer imaging-therapeutic in one step. After reaching the cancer targets, the designed targeted gold nanoparticles significantly enhance conventional treatment modalities at the cellular level. In this aspect the gold nanoparticles of the invention are modified to be bound to a Positron Emission Tomography (PET) tracer.Type: ApplicationFiled: March 27, 2009Publication date: February 11, 2010Inventors: Jie CHEN, Wilson Roa
-
Patent number: 7651770Abstract: The present invention discloses a nano-cluster that includes a plurality of nano-particles, wherein the nano-particles can disperse in response to an environmental cue. Also disclosed is a method of preventing, treating, or diagnosing a disease or condition in a subject comprising administering a therapeutically effective amount of a composition comprising nano-clusters of the present invention.Type: GrantFiled: December 14, 2006Date of Patent: January 26, 2010Assignee: The University of KansasInventors: Cory J. Berkland, Lianjun Shi
-
Publication number: 20090297437Abstract: A radioactive or radioactivable nanostructure has a core, the core including at least two atoms, at least one of which being radioactive or radioactivable, and a shell encapsulating the core and selected among a selected material so that at the most, 20% of the radioactive radiation produced by the core are stopped or absorbed by the shell and the manufacturing method thereof. The various uses of such a nanostructure, and more specifically the use thereof in the medical field, and more specifically in targeted radiotherapy are also disclosed.Type: ApplicationFiled: December 19, 2005Publication date: December 3, 2009Applicant: FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIXInventor: Stephane Lucas
-
Patent number: 7608240Abstract: The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT), and as delivery vehicles for other types of radio- and chemo-therapeutic materials, as well as imaging agents for diagnostic purposes.Type: GrantFiled: December 6, 2004Date of Patent: October 27, 2009Assignee: Board of Trustees of the University of ArkansasInventors: Dan A. Buzatu, Jon G. Wilkes, Dwight Miller, Jerry A. Darsey, Tom Heinze, Alex Biris, Richard Berger, Mark Diggs
-
Patent number: 7601331Abstract: It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at least one surfactant selected from: wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of R1, R2, R3 and R4, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 aryl, HS, COOH, NH2 or OH; R5 is COOH, NH2 or OH; with the proviso that n+m is <10; (b) an amino acid having the structure in (a), wherein X=1; Y=2; Z=1; W=1; R1, R2 and R4 are not present; R3 is NH2; and R5 is COOH; or (c) a peptide, wherein the peptide comprise at least one amino acid (b). Further, it is provided a NIR-sensitive nanoparticle complex(es) having biomolecule(s), for example drug(s), loaded on the surfactant(s).Type: GrantFiled: November 10, 2004Date of Patent: October 13, 2009Assignee: National University of SingaporeInventors: Gan Moog Chow, Mei Chee Tan, Lei Ren, Jackie Yi-Ru Ying
-
Publication number: 20090246126Abstract: A capsule for high dose rate brachytherapy, wherein the capsule comprises within its interior space thulium-170, and further comprises at least one layer of a radiation emission modifying metal (e.g., gold), wherein said layer is provided either internally within the capsule or on the outer surface thereof.Type: ApplicationFiled: April 1, 2009Publication date: October 1, 2009Applicant: Ben-Gurion University of the Negev Research and Development AuthorityInventor: Gad Shani
-
Patent number: 7591993Abstract: The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.Type: GrantFiled: October 27, 2003Date of Patent: September 22, 2009Assignee: BioSphere Medical, S.A.Inventor: Egisto Boschetti
-
Patent number: 7582279Abstract: A surface-modified lipoprotein-like oil-in-water emulsion useful as a blood-pool selective delivery vehicle for lipophilic imaging agents or lipophilic derivatives of water-soluble imaging agents. The blood-pool selective delivery vehicle remains in the blood for several hours, shows very little early hepatic sequestration, and is cleared from the blood within 24 hours. The mean diameter of the oil phase is less than 150 nm which minimizes sequestration by the reticuloendothelial system. The surface of the oil phase is modified with a polyethyl glycol-modified phospholipid to prevent normal interactions with the receptor sites of the hepatocytes.Type: GrantFiled: October 23, 2003Date of Patent: September 1, 2009Assignee: The Board of Regents of the University of MichiganInventors: Raymond E. Counsell, Marc A. Longino, Jamey P. Weichert
-
Patent number: 7566442Abstract: Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for ?v?3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.Type: GrantFiled: January 9, 2008Date of Patent: July 28, 2009Assignees: Barnes-Jewish Hospital, Bristol Myers Squibb Medical Imaging, Inc.Inventors: Gregory M. Lanza, Samuel A. Wickline, Tom Harris
-
Publication number: 20090175785Abstract: Novel peptide-based hydrogels, composed of short aromatic peptides (e.g., homodipeptides of aromatic amino acid residues) are disclosed. The hydrogels are characterized by remarkable rigidity and biocompatibility. Further disclosed are uses of these hydrogels in applications such as tissue engineering, drug delivery, cosmetics, implantation, packaging and the like. Further disclosed are processes and kits for preparing these hydrogels.Type: ApplicationFiled: October 15, 2006Publication date: July 9, 2009Inventors: Ehud Gazit, Assaf Mahler, Meital Reches
-
Publication number: 20090169471Abstract: According to an aspect of the invention, injectable particles are provided that include (a) porous polymeric particles that contain at least one type of particle-forming polymer and (b) a pore-filling composition that includes at least one therapeutic agent and at least one pore-filling polymer. The pore-filling composition at least partially fills the pores of the injectable porous polymeric particles. Other aspects of the invention pertain to methods of making such particles. Still other aspects of the invention pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions.Type: ApplicationFiled: December 19, 2008Publication date: July 2, 2009Applicant: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Robert E. Richard, John E. O'Gara, Sonali Puri
-
Publication number: 20090162277Abstract: Lipophilic compounds extracted from cell growth mediums, particularly lysophospholipids are used to solubilize single-walled nanotubes. The naturally occurring lysophospholipids were found to readily bond to the exterior wall of the single-walled nanotubes to enhance the biocompatibility of the single-walled nanotubes in therapeutic and diagnostic conditions. The solubilization protocol is simple, highly efficient, and results in a population of coated single-walled nanotubes which are highly stable.Type: ApplicationFiled: November 3, 2006Publication date: June 25, 2009Applicant: Clemson UniversityInventors: Pu-Chun Ke, Yonnie Wu, Apparao M. Rao
-
Patent number: 7541017Abstract: The invention relates to a composition comprising a colloid which is stable under physiological pH and ionic strength, said colloid comprising particles having a silica core and a shell: a) wherein said shell comprises a cross-linked poly(ethylene)imine polymer having amine functionalities; b) wherein the particles have a volume-weighted mean particle size diameter of less than 200 nm, and c) wherein greater than 50% of said polymer in the colloid is bound to the core surfaces, wherein the polymer having amine functionalities has an average molecular weight less than 100,000 g/mol, the composition has a H of between 6 and 8; and d) wherein the colloid contains between 300 and 6000 .?mol amine-monomer/g core particles.Type: GrantFiled: January 14, 2005Date of Patent: June 2, 2009Assignee: Carestream Health, Inc.Inventors: Joseph F. Bringley, Tiecheng A. Qiao, John W. Harder, Andrew Wunder, James M. Hewitt
-
Publication number: 20090110634Abstract: The present invention relates to radiolabelled nanoparticles having a radioisotope non-covalently bonded thereto. The radiolabelled nanoparticles are useful as radiopharmaceuticals. Kits and methods of preparation of the radiolabelled nanoparticles are also disclosed.Type: ApplicationFiled: July 14, 2006Publication date: April 30, 2009Inventors: Paul D. Beer, Michael Lankshear, Hema Dattani, Alex Jackson, Michelle Avory
-
Publication number: 20090110633Abstract: The present invention relates to novel nanocell compositions and their use in imaging, diagnostic and treatment methods. In one embodiment, nanocells tailored for imaging methods comprise a nanocore surrounded by a lipid matrix, and are modified to contain a radionuclide core or a nanocore with an emission spectra. The nanocells may be size restricted such as being greater than about 60 nm so that they selectively extravasate at sites of angiogenesis (e.g. tumor) and do not pass through normal vasculature or enter non-tumor bearing tissue. In this way, angiogenic sites can be both detected and treated. In another embodiment, nanocells are tailored for various treatment methods, including the treatment of brain cancer, asthma, Grave's Disease, Cystic Fibrosis, and Pulmonary Fibrosis.Type: ApplicationFiled: March 14, 2006Publication date: April 30, 2009Inventors: Shiladitya Sengupta, Ram Sasisekharan, Carlos J. Bosques, David A. Eavarone, Pochi Shum
-
Publication number: 20090098044Abstract: The present invention relates to a process for making a particulate substance. The process comprises providing an emulsion, optionally a microemulsion, comprising droplets dispersed in a continuous liquid phase. At least some of the droplets of the emulsion comprise nuclei. The droplets are then at least partially destabilised to form the particulate substance.Type: ApplicationFiled: November 15, 2005Publication date: April 16, 2009Inventors: Linggen Kong, Christophe Jean Alexandre Barbe
-
Publication number: 20090092542Abstract: This invention relates to a safe, effective, bioinert microporous radiopaque microparticles or spheres as a method and means to mark or provide “localization” of various tissues within the body and to reduce the incidence of adverse tissue reaction.Type: ApplicationFiled: July 24, 2008Publication date: April 9, 2009Inventor: Stuart K.J. Smyth
-
Publication number: 20090081122Abstract: The injectable formulation for treatment by hyperthermia comprises a liquid carrier and heat-generating superparamagnetic iron oxide nanoparticles having a mean diameter not greater than 20 nm. Said injectable formulation is able to form in-situ a hyperthermic solid or semi-solid implant upon contact with a body fluid or tissue. Said hyperthermic solid or semi-solid implant may be useful for treating a tumor or a degenerative disc disease by hyperthermia.Type: ApplicationFiled: May 23, 2005Publication date: March 26, 2009Applicants: UNIVERSITE DE GENEVE, ECOLE POLYTECHNIQUE FEDERAL DE LAUSANNE (EPFL), HOPITAUX UNIVERSITAIRES DE GENEVEInventors: Daniel Rufenacht, Eric Doelker, Olivier Jordan, Mathiew Chastellain, Alke Petri-Fink, Heinrich Hofmann
-
Patent number: 7494824Abstract: An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance associated to a linker with at least one structural element (B) capable of establishing a hydrogen bond, and involving an interaction between the structural elements (A) and (B). The interactive system is suitable for presenting and eliminating substances in liquids.Type: GrantFiled: June 29, 2005Date of Patent: February 24, 2009Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V., BerlinInventors: Elke Bucha, Götz Nowak
-
Publication number: 20090022655Abstract: The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT), and as delivery vehicles for other types of radio- and chemo-therapeutic materials, as well as imaging agents for diagnostic purposes.Type: ApplicationFiled: April 30, 2008Publication date: January 22, 2009Inventors: Dan A. Buzatu, Jon G. Wilkes, Dwight Miller, Jerry A. Darsey, Tom Heinze, Alex Birls, Richard Beger
-
Patent number: 7459145Abstract: The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.Type: GrantFiled: October 27, 2003Date of Patent: December 2, 2008Assignees: Georgia Tech Research Corporation, Emory UniversityInventors: Gang Bao, Shuming Nie, Nitin Nitin, Leslie LaConte
-
Publication number: 20080292545Abstract: Apoferritin nanoparticles with functionalized surfaces have been prepared that include preselected agents within the cavity of the apoferritin molecule and preselected functionalized surface characteristics on the outer surface of the nanoparticle. Such materials provide for utilization and selective modification in a variety of applications including therapeutic and diagnostic uses. Examples of several of these applications are described herein. In addition a method for the creation of these materials by alternatively assembling, functionalizing, or functionalizing, disassembling and reassemblying the materials provides for creative customization of various types of materials applicable for varying types of applications which are also described herein.Type: ApplicationFiled: April 4, 2008Publication date: November 27, 2008Inventors: Yuehe Lin, Guodong Liu, Hong Wu, Jun Wang, Darrell R. Fisher
-
Publication number: 20080255510Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.Type: ApplicationFiled: May 20, 2008Publication date: October 16, 2008Inventor: Lixiao WANG
-
Publication number: 20080226547Abstract: The present invention provides Hydroxyapatite (HA) incorporating an alpha-emitting radionuclide or an in vivo generator for an alpha-emitting radionuclide. The invention further provides methods for the formation of such HA, pharmaceutical compositions comprising the HA and methods of medical treatment of cancerous or noncancerous disease including administering the HA or compositions thereof.Type: ApplicationFiled: February 18, 2005Publication date: September 18, 2008Inventors: Roy H. Larsen, Gro Salberg
-
Patent number: 7407646Abstract: A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.Type: GrantFiled: October 23, 2002Date of Patent: August 5, 2008Assignee: L'Assistance Publique-Hopitaux de Paris Etablissement Public de SanteInventors: Alexandre Laurent, Denis Labarre
-
Patent number: 7364859Abstract: Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In general, the bioelastomer is conjugated to a binding compound, which is in turn used to bind a compound of interest. For targeted compound delivery, the bioelastomer is conjugated to the compound to be delivered.Type: GrantFiled: July 31, 2002Date of Patent: April 29, 2008Assignee: Duke UniversityInventor: Ashutosh Chilkoti
-
Patent number: 7344698Abstract: Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for ?v?3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.Type: GrantFiled: December 16, 2005Date of Patent: March 18, 2008Assignees: Barnes-Jewish Hospital, Bristol-Myers Squibb Medical Imaging, Inc.Inventors: Gregory M. Lanza, Samuel A. Wickline, Tom Harris
-
Publication number: 20080038190Abstract: In one embodiment, a composition comprises a microparticle including a radioactive isotope and an imageable element. In another embodiment, a method includes forming a microparticle including a target isotope and an enriched paramagnetic isotope, and transforming the target isotope into a radioactive isotope. In yet another embodiment, an apparatus includes an imaging system to image a subject; and a radioactive microparticle suitable for infusion into the subject for imaging by the imaging system and including an enriched paramagnetic isotope that is enriched to reduce generation of radioactive impurities while maintaining or improving imaging sensitivity.Type: ApplicationFiled: August 11, 2006Publication date: February 14, 2008Inventors: Thomas J. Simpson, Jim Hagerman
-
Patent number: 7311655Abstract: The invention relates to a method for producing a radioactive brachytherapy source material comprising indium-114m in radioactive equilibrium with indium-114 as main radioactive isotopes. A new radioactive brachytherapy source material comprises indium-114m in radioactive equilibrium with indium-114 as main radioactive isotopes. A new encapsulated radioactive brachytherapy source comprises the new radioactive brachytherapy source material.Type: GrantFiled: March 17, 2003Date of Patent: December 25, 2007Assignee: Nucletron B.V.Inventor: Dennis Robert Schaart
-
Patent number: 7294329Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer.Type: GrantFiled: July 18, 2002Date of Patent: November 13, 2007Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Ni Ding
-
Patent number: 7276254Abstract: A method of forming polymeric microspheres for biomedical applications includes forming polymeric microspheres by an emulsion/aggregation process from a precursor monomer species, and treating the polymeric microspheres to attach a biomedical functional material to the polymeric microspheres, where the polymeric microspheres have an average particle diameter of from about 1 to about 15 microns with a narrow particle geometric size distribution. The biomedical functional material may be, for example, a radioactive material, a radioactive precursor material, a bioactive agent, or a ligand.Type: GrantFiled: May 7, 2002Date of Patent: October 2, 2007Assignee: Xerox CorporationInventors: Patricia Ann Burns, Raj D. Patel, Hadi Khan Mahabadi, Ronald F. Ziolo
-
Patent number: 7265199Abstract: The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing excessive cell proliferation. Furthermore, it relates to films made from the polymer as well as wrappings for medical devices such as stents. It also relates to medical devices that are enclosed by a film or wrapping according to the invention.Type: GrantFiled: April 10, 2001Date of Patent: September 4, 2007Assignee: Celonova BioSciences Germany GmbHInventors: Michael Grunze, Claudia Gries
-
Patent number: 7264791Abstract: The present invention relates to a preparation method for technetium-antimony trisulfide nanocolloid, more precisely, a preparation method for technetium-antimony trisulfide nanocolloid which is characterized by the processes of mixing and stirring or irradiating of pertechnetate and antimony sulfide nanocolloid in the presence of borohydride exchange resin to obtain the technetium-antimony trisulfide nanocolloid radioactive complex.Type: GrantFiled: February 23, 2005Date of Patent: September 4, 2007Assignee: Korea Atomic Energy Research InstituteInventors: Sang Hyun Park, Kyung Bae Park, Byung Chul Shin
-
Patent number: 7252840Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.Type: GrantFiled: August 23, 2000Date of Patent: August 7, 2007Assignee: Advanced Inhalation Research, Inc.Inventors: Richard P. Batycky, Michael M. Lipp, Ralph W. Niven
-
Patent number: 7235228Abstract: This invention comprises nanoparticles for use with biosensors. The nanoparticles have core/shell architecture. The nanoparticles can be detected by two means, magnetic and optical by virtue of the nanoparticles magnetic core and fluorescent semiconductor shell. Methods of making the nanoparticles and their composition are described.Type: GrantFiled: April 15, 2003Date of Patent: June 26, 2007Assignee: The United States of America as represented by the Secretary of the NavyInventors: Everett E. Carpenter, Vincent Carpenter
-
Patent number: 7217410Abstract: A microparticle contains a cross-linked protein shell, and a surface coating.Type: GrantFiled: June 17, 2003Date of Patent: May 15, 2007Assignee: The Board of Trustees of the Universtiy of IllinoisInventors: Kenneth S. Suslick, Farah Jean-Jacques Toublan, Stephen A. Boppart, Daniel L. Marks
-
Patent number: 7201891Abstract: A coated preparation for the detection of a H. pylori infection according to a urea breath test protocol which comprises a core composition containing at least an isotope C-labeled urea, an excipient and a lubricant in defined proportions and covered with 0.1˜10 weight % of a coating agent based on 100 weight % of the core composition. With this preparation, the influence of the urease-producing bacteria resident in organs other than the stomach, such as the mouth and throat, is excluded to enable a diagnosis of H. pylori infection without the risk for a false-positive test and with reasonable rapidity.Type: GrantFiled: August 30, 2000Date of Patent: April 10, 2007Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kyoko Tsuchiya, Akio Okamura, Junichi Kawasaki, Shinichiro Uno, Atsunari Noda, Satoshi Nishiwaki
-
Patent number: 7150867Abstract: This invention relates to a particulate material comprising an inorganic low density, radiation tolerant core coated with a radionuclide, processes for its production and a method of radiation therapy utilizing the particulate material.Type: GrantFiled: June 17, 2002Date of Patent: December 19, 2006Assignee: Sirtex Medical LimitedInventors: Andrew John Ruys, Bruce Andrew Gray
-
Patent number: 7081366Abstract: A primary antibody bead suspension for an enzyme-linked immunoassay (“ELISA”) procedure is formed of a quantity of primary antibody coated magnetic beads (3) uniformly dispersed and held in suspension (9) by a thixotropic non-Newtonian fluid (1). To remove the thixotropic non-Newtonian fluid prior to application in the ELISA procedure, a magnet (12) is placed against the side of the non-magnetic vessel (9) holding the suspension to draw the magnetic beads against the side while the thixotropic fluid is washed away by pumping (14,16,15& 17) and replaced by a saline buffer solution.Type: GrantFiled: June 2, 2003Date of Patent: July 25, 2006Assignee: Northrop Grumman CorporationInventors: Brian M. Sullivan, Denes L. Zsolnay
-
Patent number: 7074386Abstract: A method for capturing specified materials which includes contacting a microporous material with a hydrostatic fluid having at least one specified material carried therein, under pressure which structurally distorts the lattice sufficiently to permit entry of the at least one specified material. The microporous material is capable of undergoing a temporary structural distortion which alters resting lattice dimensions under increased ambient pressure and at least partially returning to rest lattice dimensions when returned to ambient pressure. The pressure of the fluid is then reduced to permit return to at least partial resting lattice dimension while the at least one specified material is therein. By this method, at least one specified material is captured in the microporous material to form a modified microporous material.Type: GrantFiled: November 25, 2002Date of Patent: July 11, 2006Assignee: Brookhaven Science Associates, LLCInventors: Thomas Vogt, Joseph A. Hriljac, Yongjae Lee
-
Patent number: 7033571Abstract: A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.Type: GrantFiled: November 3, 2003Date of Patent: April 25, 2006Assignee: Battelle Memorial InstituteInventors: Anna Gutowska, Karol J. Krzyminski
-
Patent number: RE40059Abstract: A process for stabilizing a sensitive substance; (a) plating a sensitive substance onto a solid carrier under a controlled atmosphere to reduce loss of the sensitive substance; (b) encapsulating the plated material under controlled atmosphere and airflow to reduce volatilization during the process and stabilize the sensitive substance.Type: GrantFiled: November 29, 2001Date of Patent: February 12, 2008Assignee: Balchem CorporationInventors: Carl J. Pacifico, Wen-Hsin Wu, Marta Fraley