Abstract: New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.

Abstract: In a personal care daily practice, common human malodor in breath can be treated and eliminated or substantially reduced through the use of a treatment comestible, lozenge, chewing gum or scraper prepared by combining a hardenable natural or artificial sweetener or gum base with an amount of activated carbon effective in reducing such malodors.

Abstract: Methods and compositions for reducing animal waste malodor using agents and cross-adapting agents are described.

Abstract: The invention provides a composition which is effective in the prevention or delay of the onset of side effects associated with alcohol consumption or the reduction or alleviation of those effects. The composition of the invention includes activated charcoal and limestone, optionally activated limestone. Optionally, the composition of the invention also includes vitamin B1 and/or other agents such as fatigue relieving agents. Preferably, the composition of the invention is provided in the form of tablets or powder encapsulated in a gelatin capsule. The composition of the invention is provided in pre-dosed quantities varying from between about 100 and 500 milligrams per dose. The invention also provides a method of reducing or alleviating the deleterious effects associated with alcohol consumption.

Abstract: Aqueous slurries for cleaning the tongue and throat comprising finely-divided charcoal, water and an alcohol biocide, optionally in the form of a kit, are disclosed.

Abstract: This invention relates to use of activated charcoal in oral drug preparation for hyperthyroidism therapy. There is no side effect after taking oral drug preparation of activated charcoal in hyperthyroidism patients. Activated charcoal is in particle form not decomposed in human's intestinal tract and cannot be absorbed into blood while depressing serum thyroid hormones level rapidly. It is available completely in all kinds of clinical conditions when there are contraindications of antithyroid drugs and antithyroid drugs can not work promptly.

Abstract: The invention provides a composition which is effective in the prevention or delay of the onset of side effects associated with alcohol consumption or the reduction or alleviation of those effects. The composition of the invention includes activated charcoal and limestone, optionally activated limestone. Optionally, the composition of the invention also includes vitamin B1 and/or other agents such as fatigue relieving agents. Preferably, the composition of the invention is provided in the form of tablets or powder encapsulated in a gelatin capsule. The composition of the invention is provided in pre-dosed quantities varying from between about 100 and 500 milligrams per dose. The invention also provides a method of reducing or alleviating the deleterious effects associated with alcohol consumption.

Abstract: A fullerene-antibiotic conjugate including at least one antibiotic molecule per fullerene moiety. The fullerene may comprise C60 and the antibiotic may comprise vancomycin or may be selected from the group consisting of penicillins, cephalosporins, quinolones, fluoroquinolones, macrolides, lincosamines, carbepenems, conobactams, aminoglycosides, glycopeptides, tetracyclines, sulfonamides, rifampin, oxazolidonones, and streptogramins. The conjugate preferably includes at least two and more preferably at least three antibiotic molecules per C60 center. A method for making a fullerene(C60)-antibiotic conjugate, comprises: synthesizing a linker precursor (I); reacting the linker precursor (I) with C60 via a Bingel-reaction, to produce a fullerene-linker conjugate (II); hydrolyzing the fullerene-linker conjugate (II), resulting in a desired derivative of C60 (III); and reacting the derivative (III) with a desired antibiotic to produce a fullerene-antibiotic conjugate (IV).

Abstract: Anti-fouling compositions are disclosed. The compositions comprise a film-forming resin and effective amounts of graphite and copper. Methods for using the compositions are also disclosed, as are substrates coated with the compositions. The coatings find particular application on substrates that are submerged for extended periods of time in salt water. Methods for promoting oyster cultivation are also disclosed.

Abstract: A medical adsorbent which produces minimal side-effects such as constipation, has excellent adsorption for ionic organic compounds such as causative substances of uremia, exhibits adequate adsorption performance at low doses and avoids adsorption of high-molecular compounds necessary for the body, such as enzymes and polysaccharides. The medical adsorbent comprises activated carbon obtained by carbonizing a spherical phenol resin in a nitrogen atmosphere at a temperature of 400-1000° C., activating the carbonized spherical phenol resin at a temperature of 800-1000° C., washing it with dilute hydrochloric acid, heat treating it at a temperature of 150-1000° C. in a mixed gas comprising oxygen and nitrogen and then sorting it; the activated carbon has an area to weight ratio of 500-2000 m2/g, a pore volume of 0.2-1.0 mL/g and a packing density of 0.5-0.75 g/mL.

Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.

Abstract: Aqueous slurries, capable of cleaning the tongue and throat of a patient when used by an individual for personal hygiene or used on another warm-blooded animal, combine finely-divided charcoal, water, and a biocide. Also disclosed are methods for cleaning areas of the tongue and throat in need thereof. The methods use the disclosed aqueous slurries, as well as apparatus, devices, and tools for contacting the areas to be cleaned with the aqueous slurry and for removing unwanted material from the areas cleaned, as well as from the oral cavity, generally. The disclosed methods can be safely practiced for personal oral hygiene, or on another. Further, kits are disclosed that are useful for such cleaning in providing a contained quantity of a disclosed aqueous slurry or contained quantities of the components thereof, as well as apparatus, devices and tools for effectively preparing and using the same for the above purposes.

Abstract: A method for providing bone therapy in a patient in need of bone therapy comprises administering to the patient a pharmaceutically effective amount of a compound comprising a biologically inert carrier, a bone vector; and a therapeutic agent. The bone vector preferably comprises a bisphosphonate, the carrier preferably comprises a fullerene, and more preferably C60, the therapeutic agent preferably comprises fluoride.

Abstract: The present invention provides a method for treating disorders of the swallowing system, including injecting a modifier composed of biocompatible particles and a biocompatible carrier into one or more desired tissue sites. The present invention may be injected at a tissue site of a patient's mouth, pharynx, nasal passages, esophagus, trachea or other suitable tissue sites to treat snoring and other tissue disorders.

Abstract: Novel aqueous slurries capable of removing calculus, plaque or stains, adherent to tooth surfaces of a warm-blooded animal, when used in methods that are self-practicable by an individual human or practicable by an individual human on another warm-blooded animal, combine finely-divided charcoal; water; and alcohol, ammonia or hydrogen peroxide to form the slurries. Also disclosed are self-practicable methods that utilize the disclosed aqueous slurries by applying to, and contacting affected tooth surfaces with, the same, then removing the treated calculus, plaque or stains by means of devices and techniques that are safe to use according to the methods. Further, kits are disclosed that comprise the disclosed aqueous slurries, as well as apparatus, devices and tools for effectively using the same for the above purposes.

Abstract: The invention provides a composition which is effective in the prevention or delay of the onset of side effects associated with alcohol consumption or the reduction or alleviation of those effects. The composition of the invention includes activated charcoal and limestone, optionally activated limestone. Optionally, the composition of the invention also includes vitamin B1 and/or other agents such as fatigue relieving agents. Preferably, the composition of the invention is provided in the form of tablets or powder encapsulated in a gelatin capsule. The composition of the invention is provided in pre-dosed quantities varying from between about 100 and 500 milligrams per dose. The invention also provides a method of reducing or alleviating the deleterious effects associated with alcohol consumption.

Abstract: The present invention provides a syringe and a hypodermic needle having both linear and arcuate segments for injecting bulking agents into soft tissue planes between an organ and surrounding sphincter muscle to treat undesired sphincter-related deficiencies such as stress urinary incontinence, anal incontinence and esophageal reflux. A penetration depth shield or guide may be added to the hypodermic needle to limit the penetration of the needle and aid in the proper positioning of the needle. In one embodiment, a method for injecting a bulking agent into the soft tissue plane between the urethra and surrounding sphincter muscle and/or proximal urethral submucosa by using a hypodermic needle having both linear and arcuate segments, a penetration depth shield and a syringe containing a bulking agent is provided. The bulking agent may comprise a plurality of discrete carbon coated substrate particles that are carried in a fluid and lubricative biocompatible medium.

Abstract: An adsorbent for an oral administration, comprising a porous spherical carbonaceous substance wherein a diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 20 to 15000 nm is from not less than 0.04 mL/g to less than 0.10 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 1.00 meq/g, is disclosed.

Abstract: Squalane, which contains fullerene useful for a complex material with high functionality including effects on improving health, is provided. Squalane in which fullerene as ultrafine particles of carbon combusting residue are floating is produced by combusting mixed gas of oxygen and hydrogen in squalane in a vacuum and heating and combusting carbon with the combustion gas obtained.

Abstract: Activated carbon, as well as compositions and kits comprising the same, are effective for preventing pregnancy and sexually transmitted diseases including HIV.

Abstract: A regimen for hunting includes using a number of activated carbon-containing personal items in connection with a hunter's apparel and body to reduce the hunter's scent for improved hunting. The personal items include mouthwash, deodorant/antiperspirant, body and boot powder, bar and liquid soap for cleansing the body and hair, laundry detergent and dryer sheets. Each of the personal items includes an effective amount of activated carbon, so that use of the personal items reduces the available scent to be detected by animals in the wild.

Abstract: A cure for a hangover containing the active ingredient ephedrine in powdered form enclosed in a capsule. In a second embodiment this cure contains ephedrine and charcoal, while in a third embodiment, this cure contains Ephedra, charcoal and Vitamin B6. The use of any one of the three embodiments reduces the symptoms associated with alcohol intoxication and hangovers thereby speeding up recovery. The Ephedra, Vitamin B-6 and charcoal may be combined on a wt % ratio of 1:2.5:10. The Ephedra may come in the form of Ma Huang having 6% wt % Ephedra. One type of dosage is in the form of individual capsules having 10 Mg of Ephedra, 25 Mg of Vitamin B-6 and 100 Mg of activated charcoal. The recommended dosage would be two capsules so that users who are experiencing a hangover or alcohol related side effects may take up to 20 Mg of Ephedra, 50 Mg of Vitamin B-6 and 200 Mg of activated charcoal.

Abstract: A skin-care pouch includes a sealed enclosure storing therein a number of carbide aggregations including carbides in the form of small pieces, granules or particles, water-absorbent shape-keeping agent which is gelled by absorbing water upon contact therewith and so on. The sealed enclosure in the form of a bag is formed of a fabric capable of permeating water and the carbides therethrough to be placed into contact with a desired portion of skin where care or treatment thereof is desired.

Abstract: The invention provides a composition which is effective in the prevention or delay of the onset of side effects associated with alcohol consumption or the reduction or alleviation of those effects. The composition of the invention includes activated charcoal and limestone, optionally activated limestone. Optionally, the composition of the invention also includes vitamin B1 and/or other agents such as fatigue relieving agents. Preferably, the composition of the invention is provided in the form of tablets or powder encapsulated in a gelatin capsule. The composition of the invention is provided in pre-dosed quantities varying from between about 100 and 500 milligrams per dose. The invention also provides a method of reducing or alleviating the deleterious effects associated with alcohol consumption.

Abstract: A regimen for hunting includes using a number of activated carbon-containing personal items in connection with a hunter's apparel and body to reduce the hunter's scent for improved hunting. The personal items include mouthwash, deodorant/antiperspirant, body and boot powder, bar and liquid soap for cleansing the body and hair, laundry detergent and dryer sheets. Each of the personal items includes an effective amount of activated carbon, so that use of the personal items reduces the available scent to be detected by animals in the wild.

Abstract: The present invention relates to a method for treating a disease, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a fullerene. The diseases treated comprise bacterial and viral diseases such as those cause by Gram positive and Gram negative bacteria, Dengue 2 virus and viral encephalitis. The fullerene is administered in vivo in an amount of about 0.001 to about 100 mg/kg of body weight of the subject.

Abstract: Injectable activated carbon suspensions are proposed for the presurgical marking of nonpalpable mammary pathologies for the purpose of achieving better diagnosis and treatment. These are suspensions that flow freely and without the formation of obstructing aggregates in the needles used during their application, with carbon particles of micron granulometry limited to less than 50&mgr; and preferably between 2&mgr; and 6&mgr; in concentration of approximately 4.0% p/v in saline aqueous medium. A process is also proposed for preparing said compositions.

Abstract: A composition for treatment of pollution comprises a first component comprising a carbon containing substance in an oil phase and a second component comprising a nutrient in a water phase, the second component being formed as an emulsion within the first component. A third component comprising a diluent is added to the first and second components.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.

Abstract: An augmented synthetic resin is provided. That resin includes carbon nanotubes dispersed in a polymethylmethacrylate matrix. The method of preparing this synthetic resin includes the mixing and disaggregating of the carbon nanotubes.

Abstract: Injectable activated carbon suspensions are proposed for the presurgical marking of nonpalpable mammary pathologies for the purpose of achieving better diagnosis and treatment.

Abstract: A composition for treating the gastrointestinal tract comprising a porous insoluble absorbent in which the pores of the insoluble absorbent are clogged by a coating material which causes the insoluble absorbent to adhere to the gastrointestinal lining. Active ingredients, including antacids, antibiotics, antibacterial agents, platelet inhibitors, antispasmodics, and soporifics, can be mixed with or absorbed into the composition.

Abstract: A unit dosage form is provided which comprises an effective amount of a radioisotope adsorbed onto activated charcoal, and which is preferably enterically coated. The unit dosage form is useful for the measurement of intestinal transit.

Abstract: A preparation for administering isotope-labelled urea together with acid in a solid form that is influenced by activity of Helicobacter pylori in the stomach only, avoiding any non-Helicobacter (unspecific) urease activity in the oral cavity and the pharynx. The preparation dissolves very quickly in the stomach. The preparation is used to show increased urease activity in the stomach in association with an ongoing Helicobacter pylori infection.

Abstract: A pyruvate compound suitable for cosmetically or dermatologically administering to the skin and for use in treating diabetic ketosis or other medical treatments. The compound includes a pyruvate selected from the group of pyruvate thioester, dihydroxyacetonepyruvate, and an ester of pyruvate and a sugar or a polyol.

Abstract: Disclosed are novel radioactive compositions which are particularly suited for treating solid mass tumors via catheter delivery.

Abstract: Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.

Abstract: This invention relates to a radioactive patch/film and process of preparation thereof. The radioactive patch/film containing radioactive material can irradiate on skin directly. The radioactive patch/film is prepared by the process, wherein, various forms of the patch/film containing stable nuclide is prepared and irradiated with neutrons. The patch/film is very effective to treat various kinds of cancers, and dermal diseases.

Abstract: An antidotal food product containing activated charcoal is provided for ingestion into the gastro-intestinal tract of a user. The antidotal food product is orally administered having the visual appearance and physical properties which enables the desire on the part of young children to chew and ingest the food product. The food product in a preferred embodiment includes a substantially dry friable wafer which is adapted to be chewed by the user for ingestion. The dry friable wafer has a wafer mixture composition formed by blending a first predetermined weight of sorbent particulate composition having an initial adsorption value with respect to a toxin to a second predetermined weight of a substantially non-interfering flavored binding composition which provides for a creamy and sweet tasting food product.

Abstract: A homeopathic topical anti-inflammatory and pain relieving composition containing an effective amount of the combination of Arnica Montana, Rhus toxicodendron and Aesculus hippocastanum together with belladonna in the form of a lotion, cream or gel.

Abstract: The disclosed invention provides agricultural chemical compositions containing active carbon-treated thifluzamide as an effective ingredient. Such compositions provide increased release of thifluzamide into water.

Abstract: An apparatus and process for administering minerals to the human body by mixing pre-selected particulated minerals with graphite and coal tar to form a bar (10a), vaporizing the bar (10a) to form a mineral rich vapor, and directing the vapor to a patient's skin using an enclosure (30).

Abstract: To provide a therapeutic dose of an aqueous slurry of activated charcoal to a poisoning victim, an opaque straw is coated internally with a viscous flavoring solution and the slurry is sucked up from an opaque container using the straw. The use of natural and/or artificial sweeteners in the slurry masks the gritty particles and improves the taste.

Abstract: Microspheres which are a matrix of a biocompatible and biodegradable polymer which is soluble in an organic solvent which is immiscible in water, within which a water-soluble substance is uniformly distributed, and wherein the residual level of toxic solvent in the microspheres is lower than 1.5% by weight, progressively and continuously releases the substance over a period of at least 8 days when the microspheres are placed in an aqueous physiological environment, with a reduced or substantially absent first phase of accelerated release. A process for producing such microspheres is provided.

Abstract: A substance for diagnosis or therapy of an animal. The substance includes an agent which is detectable or therapeutically active, the agent being linked to a carrier which is linked to a targeting site, whereby the agent accumulates in the lymphatic system of the animal to a greater degree than if the targeting site were absent.

Abstract: An agent for reducing nephrotoxicity due to a platinum complex compound, comprising an activated spherical carbon as an active ingredient is disclosed.

Abstract: The disclosure describes a method of treating a patient suffering from hemorrhoidal diseases, comprising orally administering to said patient an effective amount of a pharmaceutical composition in dosage unit form comprising a spherical activated carbon having a particle size of 0.05 to 2 mm.

Abstract: The disclosure describes a method of treating a patient suffering from stoma-peripheral inflammation diseases, comprising orally administering to said patient an effective amount of a pharmaceutical composition in dosage unit form comprising a spherical activated carbon having a particle size of 0.05 to 2 mm.

Abstract: The disclosure describes a method of treating a patient suffering from inflammatory bowel diseases, comprising orally administering to said patient an effective amount of a pharmaceutical composition in dosage unit form comprising a spherical activated carbon having a particle size of 0.05 to 2 mm.