Derived From, Or Present In, Food Product (e.g., Milk, Colostrum, Whey, Eggs, Etc.) Patents (Class 424/157.1)
  • Patent number: 10632158
    Abstract: Methods for treating and preventing dysbiosis in a subject suffering from or susceptible to gastrointestinal disorders are described. The methods comprises administering a hyperimmunized egg product to the subject, wherein the egg product is obtained from a hyperimmunized avian, optionally in combination with an additional compound such as a probiotic and/or nutrient source.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: April 28, 2020
    Assignee: IGY Nutrition
    Inventor: Susan J. Hewlings
  • Patent number: 10611828
    Abstract: The disclosure provides improved compositions and methods for passive immunization. In embodiments, a composition comprising a synergistic combination of specific polyclonal antibodies in a carrier matrix is provided. The disclosure provides effective, economical compositions and methods for the treatment of diarrhea and enteric infections in broad-spectrum, undifferentiated, or mixed clinical applications.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: April 7, 2020
    Assignee: PANTHERYX, INC.
    Inventor: Timothy W. Starzl
  • Patent number: 10602757
    Abstract: The present invention belongs to a technical field of nutrition additives for animal, and specifically discloses a nutrition supplement for animal, comprising eggs of an edible insect. Further, the eggs of the edible insect are one or more of eggs of Hermetia illucens L., eggs of Tenebrio molitor and eggs of fly. The present invention finds that the eggs of edible insect provide better effects such as enhancing nutrition, promoting growth and health care for animals, especially for newborn animals, weaning animals, weak animals or sick animals. The nutrition supplement provided by the present invention can be prepared easily and used conveniently. The present invention using the eggs of edible insect as a main component of the nutrition supplement can not only improve a health level of animals including livestock, aquatic animals and the like, but also enhance a feed intake, a feed conversion level and a comprehensive benefit of cultivation with a good application prospect.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 31, 2020
    Assignee: BIOFORTE BIOTECHNOLOGY(SHENZHEN) CO., LTD.
    Inventors: Wenfeng Hu, Xu Pang, Chujun Li, Haiyong Zhou, Jianfeng Zhu
  • Patent number: 10407494
    Abstract: A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: September 10, 2019
    Assignee: CAMAS INCORPORATED
    Inventor: Bradley M. Mitteness
  • Patent number: 10064916
    Abstract: A treatment composition for treating or preventing bovine mastitis, the treatment composition characterized in that it includes at least two components which have an isoelectric point of or above substantially 6.8 and is extracted from milk, or a milk derived substance.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: September 4, 2018
    Assignee: DEC International NZ Limited
    Inventor: Judith Mary Bragger
  • Patent number: 10059777
    Abstract: The invention provides a method of producing an immune complex preparation based on a secretory immunoglobulin, which is non-human secretion derived, comprising providing an industrial scale production system, capable of producing an N-glycosylated Secretory Component, producing by such system a Secretory Component comprising at least 0.01 mol non-core fucose per mol Secretory Component, and combining said Secretory Component with at least one of IgA or IgM immunoglobulins having a native glycosylation pattern to obtain an immune complex. The invention provides an isolated recombinant Secretory Component comprising the amino acid sequence of SEQ ID 1, or a functionally active variant thereof, which has a Lewis-type N-glucosylation pattern and at least 2 mol non-core fucose per mol Secretory Component; and an immune complex preparation based on a secretory immunoglobulin, derived from sources other than human secretions, comprising a Secretory Component with a Lewis-type N-glucosylation pattern and at least 0.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: August 28, 2018
    Inventor: Gottfried Himmler
  • Patent number: 9861687
    Abstract: The invention relates to a protein material includes angiogenin and/or angiogenin hydrolysate in an amount of 2 to 15 mg/100 mg, and lactoperoxidase and/or lactoperoxidase hydrolysate, in the mass ratio to angiogenin and/or angiogenin hydrolysate of 0.3 to 20.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: January 9, 2018
    Assignee: MEGMILK SNOW BRAND CO., LTD.
    Inventors: Aiko Ohmachi, Hiroaki Matsuyama, Yoshikazu Morita, Yuko Ishida, Takayuki Nara, Ken Kato, Atsushi Serizawa
  • Patent number: 9849175
    Abstract: A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air. The adherence inhibiting material can be formulated for use in a variety of ways such as an oral spray or a nasal spray. These formulations can be effective to prevent or reduce respiratory illnesses in animals and humans.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: December 26, 2017
    Assignee: CAMAS INCORPORATED
    Inventors: Bradley M Mitteness, Connie Phillips
  • Patent number: 9701735
    Abstract: The disclosure provides improved compositions and methods for passive immunization. In embodiments, a composition comprising a synergistic combination of specific polyclonal antibodies in a carrier matrix is provided. The disclosure provides effective, economical compositions and methods for the treatment of diarrhea and enteric infections in broad-spectrum, undifferentiated, or mixed clinical applications.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: July 11, 2017
    Assignee: PANTHERYX, INC.
    Inventor: Timothy W. Starzl
  • Patent number: 9701737
    Abstract: A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: July 11, 2017
    Assignee: CAMAS, INCORPORATED
    Inventors: Peter Nash, Bradley M. Mitteness
  • Patent number: 9644033
    Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 9, 2017
    Assignee: Universite De Reims Champagne Ardenne
    Inventors: Jacques Henri Max Cohen, Wael Mahmoud, Marcelle Tonye Libyh, Nathalie Godin, Annelise Gimenez, Thierry Tabary, Beatrice Donvito, Daniel Baty, Xavier Dervillez
  • Patent number: 9522116
    Abstract: A solid oral form of an antibody-based medicinal preparation comprises an effective carrier quantity irrigated with an active form of an antibody aqueous-alcoholic dilution, which is prepared by combining a repeated successive antibody dilution with an external action, and pharmaceutically acceptable additives. The inventive method for producing a solid oral form of the antibody-based medicinal preparation consists in preparing an aqueous-alcoholic dilution of anti-substance antibodies, obtaining the active form by combining a repeated successive dilution and an external action according to a homeopathic process, irrigating a carrier with the thus obtained aqueous-alcoholic dilution in a fluidized boiling bed with concurrent drying of said carrier at a temperature equal to or less than 35° C., mixing in a pharmaceutically acceptable sequence with pharmaceutically acceptable additives and in subsequent pelletization—forming tablets by means of a direct dry pressing.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: December 20, 2016
    Assignee: Oleg Iliich Epshtein
    Inventor: Oleg Iliich Epstehin
  • Patent number: 9101670
    Abstract: Conjugates of an anti-TNF antibody and one or more nonpeptidic water soluble polymers are provided. Typically, the nonpeptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: August 11, 2015
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Gayle Stephenson
  • Patent number: 9028827
    Abstract: The present invention relates to a method for treating hepatitis virus infection comprising administering to a subject infected with a hepatitis virus an effective amount of a yolk or yolk antibody obtained from an egg of a fowl which has been immunized using Helicobacter pylori as an antigen. In particular, the method is effective in reducing virus titer and/or decreasing a level of glutamic oxaloacetic transaminase (GOT) or glutamic pyruvic transaminase (GPT) in the subject. Also provided is a composition for treating hepatitis virus infection which comprises the yolk or yolk antibody in combination with one or more supplemental ingredients such as Salviae Miltiorrhiza Radix, Oldennlandiae Hb., Zingiberis Radix, Ginseng Radix, Atractylodis Radix, Curcumae Radix, Angelicae Sinensis Radix, bee propolis, calcium lactate, soy proteins, probiotics, and grain bran.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: May 12, 2015
    Assignee: Asia Hepato Gene Co.
    Inventor: David C. P. Chen
  • Patent number: 8993729
    Abstract: Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds whose genome is comprised of trangene-derived exogenous antibody-encoding DNA express exogenous antibodies having desirable chemical properties with increased therapeutic utility compared to antibodies derived from bacterial expression systems.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: March 31, 2015
    Assignee: Synageva Biopharma Corp.
    Inventors: Lei Zhu, Wen Zhou, Robert J. Etches
  • Patent number: 8916156
    Abstract: A method for separating proteins and fats from an egg mixture is disclosed herein. The method includes a step of microfiltration of the egg mixture, wherein microfiltration includes pumping across a filter an egg mixture containing egg yolk and egg whites (albumen). An egg powder obtained from egg and a high gel strength egg powder are also disclosed.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: December 23, 2014
    Assignee: Rembrandt Enterprises, Inc.
    Inventor: David Mason
  • Patent number: 8834878
    Abstract: A method for the treatment of cancer is provided wherein a cancer recognition (CARE) antigen or CARE antibody is administered to a patient. Administration of the CARE antigen or antibody will induce an immune or promote a response of IgM CARE antibodies which will bind to CARE antigen bound to cancer cells, inducing an immune response to destroy the cancer cells. Subsequent to said treatment, ELISA assays may be used to detect levels of said CARE antigen to monitor the efficacy of the treatment, and to govern the further administration of CARE antigens.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: September 16, 2014
    Inventor: Jerry T. Thornthwaite
  • Patent number: 8821878
    Abstract: The disclosure features methods of making compositions that include a human lipid. The methods can include: obtaining whole human milk; separating the milk into a cream portion and a skim portion; processing the cream portion; and pasteurizing the processed cream portion.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: September 2, 2014
    Assignee: Prolacta Bioscience, Inc.
    Inventors: Elena M. Medo, Scott Eaker
  • Patent number: 8785603
    Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. Also provided are methods and reagents for the detection or quantification of 25-hydroxyvitamin D2 and D3, methods for stabilizing vitamin D analogs, and methods for separating 25-hydroxyvitamin D2 and D3 from vitamin D binding protein in a biological sample.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: July 22, 2014
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Niver Panosian Sahakian, Bruce A. Campbell, Spencer Hsiang-Hsi Lin, James Vincent Freeman, Qimu Liao, Ramon A. Evangelista
  • Publication number: 20140147446
    Abstract: The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition.
    Type: Application
    Filed: October 23, 2013
    Publication date: May 29, 2014
    Applicant: AVAXIA BIOLOGICS, INCORPORATED
    Inventor: Barbara S. Fox
  • Patent number: 8728539
    Abstract: Disclosed is a method of enhancing absorption (pinocytosis efficiecy) of immunoglobulins administered to postnatal domestic mammals (e.g., bovine) by using selenium. As an example of a selenium compound added, sodium selenite is particularly effective.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: May 20, 2014
    Assignee: Incorporated Administrative Agency, National Agriculture and Bio-Oriented Research Organization
    Inventors: Hachiro Kamada, Itoko Nonaka
  • Patent number: 8715671
    Abstract: The present invention relates to a method for modulating immune response in a subject, which comprises administering to the subject an effective amount of a composition comprising a yolk or yolk antibody obtained from an egg of a fowl which has been immunized using Helicobacter pylori as an antigen. In particular, the method of the invention is effective in enhancing production of IFN-?? and suppressing production of IL-4 and IL-5 in a subject. Also provided is a composition which comprises said yolk or yolk antibody in combination with polypore and chitosan.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: May 6, 2014
    Assignee: Asia Hepato Gene Co.
    Inventors: David C. P. Chen, Yi-Shu Chung
  • Publication number: 20140065161
    Abstract: A treatment composition for treating or preventing bovine mastitis, the treatment composition characterised in that it includes at least two components which have an isoelectric point of or above substantially 6.8 and is extracted from milk, or a milk derived substance.
    Type: Application
    Filed: September 4, 2013
    Publication date: March 6, 2014
    Applicant: DEC International NZ Limited
    Inventor: Judith Mary Bragger
  • Patent number: 8647626
    Abstract: In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered permeability of the digestive tract. Antibodies are described with increased stability within the environment of the digestive tract. Antibodies are described with enhanced permeability to a compromised digestive tract.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: February 11, 2014
    Assignee: Avaxia Biologics, Incorporated
    Inventor: Barbara S. Fox
  • Patent number: 8642038
    Abstract: A method for separating proteins and fats from an egg mixture is disclosed herein. The method includes a step of microfiltration of the egg mixture, wherein microfiltration includes pumping across a filter an egg mixture containing egg yolk and egg whites (albumen). An egg powder obtained from egg and a high gel strength egg powder are also disclosed.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: February 4, 2014
    Assignee: Rembrandt Enterprises, Inc.
    Inventor: David Mason
  • Publication number: 20140010822
    Abstract: This invention provides methods and compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal barrier of the digestive tract but do not deliver levels of antibody to the systemic circulation that have been shown to be necessary for clinical benefit following systemic administration of antibody. This invention further describes therapeutic compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal barrier of the digestive tract but do not deliver levels of antibody to the systemic circulation that have been associated with adverse events and systemic immunosuppression following systemic administration of antibody.
    Type: Application
    Filed: August 21, 2013
    Publication date: January 9, 2014
    Applicant: Avaxia Biologics, Incorporated
    Inventors: BARBARA S. FOX, Douglas C. Stafford
  • Patent number: 8623372
    Abstract: The present invention relates to antibodies immunologically specific for an attaching and effacing Escherichia coli (AEEC) virulence-associated protein, products, compositions and methods and to their use thereof in the prevention of an AEEC infection in a mammal. The antibody of the invention is immunologically specific for an AEEC virulence-associated protein and is capable of preventing an in vivo AEEC intestinal infection when administered to a mammal. The antibody of the invention is preferably useful for preventing the development of A/E intestinal lesions associated with the AEEC. This is achieved by preferably using IgY antibodies immunologically specific for one or more AEEC virulence-associated proteins, such as Eae, Tir, EspA and Paa.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: January 7, 2014
    Assignee: Valorisation-Recherche, Societe En commandite
    Inventors: John M. Fairbrother, Josée Harel, Isabelle Batisson, Francis Girard, Marie-Pierre Guimond
  • Patent number: 8609098
    Abstract: Disclosed are a composition for inhibiting hyperlipidemia and obesity through suppression of intestinal cholesterol absorption. An IgY-type antibody derived from yolk to NPC1L1 (Niemann-Pick C1-Like1), contained, as an active ingredient, in the composition of the present invention is linked to NPC1L1 (Niemann-Pick C1-Like1) that is a cholesterol transport protein in the intestines, thus interfering with binding between cholesterol and the transport protein to completely block absorption of cholesterol in the body and thereby prevent hyperlipidemia and obesity.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: December 17, 2013
    Assignees: Adbiotech Co., Ltd., Bioceltran Co., Ltd.
    Inventors: Sang Ho Jang, Soo Young Choi, Yeom Pyo Lee, Jae Jin An, Hong Gul Cheong, Hyuck Se Kwon, Jeong Keum Park, Doo Yeon Baek
  • Publication number: 20130330354
    Abstract: The present invention is directed to shelf-stable liquid egg material, methods for making the same, and method of using the same. The present invention is also directed to an animal feed supplement containing a stabilized IgY antibody titer in liquid eggs stored at room temperature for extended periods of time with the use of glycerol and preservatives. The stabilized liquid whole egg or stabilized liquid yolks of the egg containing non-specific or elevated specific IgY titer may be used as animal feed supplements animals to provide passive immunity to these animals. The stabilized nature of the IgY and liquid egg allows for extended shelf life of these liquid products at room temperature.
    Type: Application
    Filed: June 28, 2013
    Publication date: December 12, 2013
    Inventors: Daniel J. DuBourdieu, Rajiv Lall
  • Patent number: 8592560
    Abstract: The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: November 26, 2013
    Assignee: Avaxia Biologics, Incorporated
    Inventor: Barbara S. Fox
  • Publication number: 20130295109
    Abstract: The present invention provides a method of preparing an antibody containing milk or egg product for use in preventing and/or treating of a non infectious medical condition. The invention also provides non-systemic modes of administering pharmaceutical compositions including the antibody containing milk or egg products, including to the GI tract.
    Type: Application
    Filed: June 26, 2013
    Publication date: November 7, 2013
    Inventor: Antony William SCAMMELL
  • Publication number: 20130224216
    Abstract: Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.
    Type: Application
    Filed: August 17, 2011
    Publication date: August 29, 2013
    Inventors: Yaron Ilan, Gadi Lalazar, Tomer Adar, Meir Mizrahi, Ami Ben-Ya'acov
  • Patent number: 8475849
    Abstract: A formulation for well-being in humans including: extracts from the herbal varieties, Polygonum multiflorum, Panax quinquefolium, Gingko biloba, and Equisetum arvense; beta sitosterol methyl sulfonyl methane; soy isoflavones; levo-arginine; inositol; niacin; pantothenic acid or salts thereof; alpha-tocopherol; biotin; pyridoxine hydrochloride zinc (or amino acid chelate thereof); and colostrum.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: July 2, 2013
    Assignee: Dolphst Pty Ltd.
    Inventor: Jon Phillips
  • Publication number: 20130164302
    Abstract: The present invention relates to immunomodulatory compositions comprising mammalian colostrum-derived immunoglobulin preparation and optionally further colostrums, milk or milk product component/s and any adjuvants for treating immune-related disorders. More specifically, the invention provides compositions comprising colostrum-derived anti-insulin immunoglobulin preparations for the treatment of Metabolic Syndrome. The invention further provides methods and uses of the immunomodulatory compositions for an active or passive immunization in a disease-antigen specific or non specific manner.
    Type: Application
    Filed: December 14, 2012
    Publication date: June 27, 2013
    Applicant: Immuron Limited
    Inventor: Immuron Limited
  • Patent number: 8440239
    Abstract: A formulation for trichological treatment of a patient including, in a dosage in the range of 3 g to 8 g: phytosterols in the range of 200 mg to 2500 mg; the quantitative equivalent of Polygonum multiflorum root 4:1 in 70% EW in the range of 600 mg to 2600 mg; methylsulfonylmethane in the range of 500 mg to 2000 mg; and bovine colostrum in the range of 500 m to 2000 m.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: May 14, 2013
    Assignee: Dolphst Pty Ltd.
    Inventor: Jon Phillips
  • Patent number: 8440203
    Abstract: The present invention discloses methods for protecting newborn calves against neonatal diarrhea by vaccinating pregnant cows and/or pregnant heifers, while minimizing the number of separate occasions producers are required to assemble the cattle.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: May 14, 2013
    Assignee: Intervet Inc.
    Inventors: Terri L. Wasmoen, Huchappa Jayappa, Randall Gene Davis, Catherine M. Peters
  • Patent number: 8435526
    Abstract: In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered permeability of the digestive tract. Antibodies are described with increased stability within the environment of the digestive tract. Antibodies are described with enhanced permeability to a compromised digestive tract.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: May 7, 2013
    Assignee: Avaxia Biologies, Incorporated
    Inventor: Barbara S. Fox
  • Publication number: 20130058943
    Abstract: The invention provides a composition comprising polyclonal antibodies that specifically bind to with human tumor necrosis factor (hTNF) wherein the polyclonal antibodies are derived from the serum, milk or colostrum of a bovine animal that has been immunized hTNF or an immunogenic portion thereof. The antigenic specificity analysis of the anti-hTNF polyclonal antibodies of the invention is unique and has not been previously described for anti-hTNF polyclonal or monoclonal antibodies of the prior art.
    Type: Application
    Filed: August 1, 2012
    Publication date: March 7, 2013
    Inventors: Barbara S. Fox, Eileen F. Bostwick, Daniel E. Tracey, Lisa D. Schlehuber, Michael S. Quesenberry
  • Patent number: 8383125
    Abstract: The present invention provides improved antimicrobial compositions comprising peptide fragments of tammar wallaby milk proteins and analogs and derivatives thereof exemplified by the amino acid sequences of SEQ ID Nos: 1-40 and uses therefor in the treatment of a range of infections by bacteria and fungi. The antimicrobial compositions are particularly useful for broad spectrum applications, especially for the treatment of bacterial infections.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: February 26, 2013
    Assignee: Agriculture Victoria Services Pty, Limited
    Inventors: Benjamin Cocks, Jianghui Wang, Jane Whitley
  • Publication number: 20130045213
    Abstract: The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition.
    Type: Application
    Filed: August 21, 2012
    Publication date: February 21, 2013
    Inventor: Barbara S. Fox
  • Patent number: 8377445
    Abstract: The disclosure features methods of making compositions that include a human lipid. The methods can include: obtaining whole human milk; separating the milk into a cream portion and a skim portion; processing the cream portion; and pasteurizing the processed cream portion.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: February 19, 2013
    Assignee: Prolacta Bioscience, Inc.
    Inventors: Elena M. Medo, Scott Eaker
  • Publication number: 20130011410
    Abstract: The present invention provides the method for prevention and treatment of specific localized intestinal infections and diseases using IgA and IgM antibodies obtained from the eggs of hens which have been hyperimmunized to the same specific infections and diseases. The invention describes the high functionality of IgA and IgM antibodies present in the white of an egg from a hyperimmunized chicken as compared to the IgY from the same egg. The invention also describes the resistance of IgA and IgM to low pH environments such as stomach acids. The invention also describes the inhibition of bacterial growth when bacteria are exposed to IgA antibodies specific to said bacteria together with lysozyme from egg whites.
    Type: Application
    Filed: July 7, 2011
    Publication date: January 10, 2013
    Inventors: Hugh B. Fackrell, Linton W. Lee
  • Patent number: 8282928
    Abstract: The present invention relates to compositions for ameliorating the symptoms of celiac disease or gluten sensitive enteropathy comprising egg yolk antibodies against gluten, including gliadin, high molecular glutenin, low molecular glutenin and mixtures of the three peptides. The antibodies may be produced by immunizing laying hens with immunogenic preparations of gluten and harvesting the eggs and egg yolks.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: October 9, 2012
    Assignee: The Governors of the University of Alberta
    Inventors: Hoon Sunwoo, Jeong Sim
  • Patent number: 8282927
    Abstract: The invention relates to the production of compositions containing IgA for use as a food additive. More specifically, it relates to a process to prepare an IgA-enriched milk product extract composition and to such compositions.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: October 9, 2012
    Assignee: Murray Goulburn Co-Operative Co Limited
    Inventors: Andrew Brown, Peter Hobman, Richard Paine, Michelle Rowney
  • Patent number: 8211435
    Abstract: A composition for prevention digestive infection in a ruminant infant is disclosed. The composition consists of: a predetermined amount of yolk immunoglobulin (IgY) for a target bacteria; a predetermined amount of a plurality of hormones and a predetermined amount of a plurality of proteins, wherein said plurality of hormones comprises of a group consisting of bovine insulin (bIns), bovine growth hormone (bGH), and bovine prolactine (bPrl), and wherein said plurality of proteins comprises of a group consisting of, bovine insulin like growth factor (bIGF), lactoferrin factor (LF), and transferring factor (TF); and a predetermined amount of bacterial biomass, wherein said bacterial biomass comprises of a group consisting of bacterial DNA, bacterial RNA, bacterial protein, and bacterial polysaccharides.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 3, 2012
    Inventor: Hamid Reza Rahmani
  • Patent number: 8182818
    Abstract: In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered permeability of the digestive tract. Antibodies are described with increased stability within the environment of the digestive tract. Antibodies are described with enhanced permeability to a compromised digestive tract.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: May 22, 2012
    Assignee: Avaxia Biologics, Inc.
    Inventor: Barbara S. Fox
  • Patent number: 8110188
    Abstract: The invention refers to anticoccidial compositions consisting mainly of yolk immunoglobulins derived from eggs of hens immunized with one or more Eimeria species. The invention refers also to the use of said anticoccidial compositions for prevention or treatment of coccidiosis. The administration of immunoglobulins, both in liquid as well as in powder or pellet presentation, decreases mortality, lesions, oocysts counts and increases weight gain of receiving animals.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: February 7, 2012
    Assignee: Investigacion Aplicada, S.A. de C.V.
    Inventors: Jose Andres Morales Garzon, Eduardo Lucio Decanini
  • Publication number: 20120020982
    Abstract: A formulation for trichological treatment of a patient including, in a dosage in the range of 3 g to 8 g: phytosterols in the range of 200 mg to 2500 mg; the quantitative equivalent of Polygonum multiflorum root 4:1 in 70% EW in the range of 600 mg to 2600 mg; methylsulfonylmethane in the range of 500 mg to 2000 mg; and bovine colostrum in the range of 500 m to 2000 m.
    Type: Application
    Filed: January 18, 2011
    Publication date: January 26, 2012
    Inventor: Jon PHILLIPS
  • Publication number: 20120014963
    Abstract: The present invention relates generally to the field of nutrition, health and wellness. In particular the present invention relates to probiotics and ways to increase their effectiveness. One embodiment of the present invention relates to a combination of probiotics with secretory IgA and possible uses of this combination. For example a use of a composition comprising secretory IgA and at least one probiotic for the preparation of a product to treat or prevent infection is disclosed.
    Type: Application
    Filed: June 16, 2009
    Publication date: January 19, 2012
    Applicant: NESTEC S.A.
    Inventors: Jalil Benyacoub, Blaise Corthesy, Stephanie Blum-Sperisen, Laurent Favre
  • Publication number: 20120009198
    Abstract: The present invention relates to a method for modulating immune response in a subject, which comprises administering to the subject an effective amount of a composition comprising a yolk or yolk antibody obtained from an egg of a fowl which has been immunized using Helicobacter pylori as an antigen. In particular, the method of the invention is effective in enhancing production of IFN-? and suppressing production of IL-4 and IL-5 in a subject. Also provided is a composition which comprises said yolk or yolk antibody in combination with polypore and chitosan.
    Type: Application
    Filed: July 7, 2010
    Publication date: January 12, 2012
    Applicant: ASIA HEPATO GENE CO.
    Inventors: David C. P. Chen, Yi-Shu Chung