Abstract: The present invention relates to methods of immunization of aquaculture species by introducing DNA expression systems into the aquaculture species. Such DNA expression systems preferably include DNA sequences encoding polypeptides of pathogens of species of aquaculture. The present invention also relates to methods of administration of DNA expression systems into aquaculture. Such methods include injection, spray, and immersion techniques. The methods of this invention are useful for prophylactic vaccination or therapeutic immunization of fin-fish, shellfish, or other aquatic animals against infectious diseases.
Type:
Grant
Filed:
July 14, 1998
Date of Patent:
January 30, 2001
Assignee:
Loeb Health Research Institute at The Ottawa Hospital
Abstract: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
January 2, 2001
Assignee:
Connaught Laboratories Limited
Inventors:
Michel H. Klein, Run-Pan Du, Mary E. Ewasyshyn