Virus Or Component Thereof Patents (Class 424/204.1)
  • Patent number: 8415525
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: April 9, 2013
    Assignee: Zoetis W LLC
    Inventors: André Jestin, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec
  • Publication number: 20130084306
    Abstract: Described are vaccines having one or more antigens cholesterol and CpG. Aspects of the invention relate to the use of the vaccines of the invention for the treatment and/or prevention of human and animal disorders.
    Type: Application
    Filed: May 27, 2011
    Publication date: April 4, 2013
    Applicant: Coley Pharmaceutical Group Inc.
    Inventors: Heather Lynn Davis, Risini Weeratna, Paul J. Dominowski
  • Patent number: 8409588
    Abstract: A foot and mouth disease virus (FMDV) vaccine and method for producing same is described wherein the N terminal portion of the FMDV polyprotein, encoding the four structural proteins, 1A, 1B, 1C, and 1D, are each separated by a non-FMDV protease, preferably a cellular protease, for example, furin. The expression system may be transformed into a cell expressing the non-FMDV protease and the resulting particles recovered for use as a vaccine.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: April 2, 2013
    Inventors: Markus Czub, Alfonso Clavijo
  • Publication number: 20130078275
    Abstract: Embodiments described herein provide novel bacterial-based methods, systems, and delivery vehicles capable of delivering DNA, RNA, proteins, and other cargo into targeted mammalian cells, both in vitro and in vivo, with high efficiency. Delivery vehicles may be used to deliver molecules such as prophylactic or therapeutic proteins, DNA, shRNA, DNA vaccines, mucosal vaccines, modified viruses or viral components, and other bioactive molecules. Potential applications include gene therapy, wound healing therapies, cancer therapy, immune modulation, and research applications for which delivery of DNA, RNA, proteins, or other cargo into mammalian cells and tissues is required.
    Type: Application
    Filed: May 25, 2011
    Publication date: March 28, 2013
    Applicant: The Board of Trustees of the University of Illinois
    Inventor: Lin Tao
  • Publication number: 20130071429
    Abstract: The present invention provides attenuated viruses for use as vaccines and for the treatment and/or prevention of viral diseases and/or infections.
    Type: Application
    Filed: January 28, 2011
    Publication date: March 21, 2013
    Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
    Inventors: Benjamin Brennan, Richard Michael Elliott
  • Publication number: 20130071431
    Abstract: The invention relates to the preservation of an active agent, such as a polypeptide, by contacting the active agent with a preservation mixture including a sugar and polyethyleneimine.
    Type: Application
    Filed: November 13, 2012
    Publication date: March 21, 2013
    Applicant: Stabilitech Ltd.
    Inventor: Stabilitech Ltd.
  • Publication number: 20130071430
    Abstract: It is intended to provide a vaccinia virus that specifically proliferates in a cancer cell and destroys the cancer cell and to provide use of the virus in cancer treatment. The present invention provides a microRNA-controlled vaccinia virus, in which a target sequence of a microRNA less expressed in a cancer cell than in a normal cell is inserted in a 3? untranslated region of B5R gene associated with viral proliferation in a vaccinia virus, wherein the microRNA-controlled vaccinia virus specifically proliferates in the cancer cell and has an oncolytic property that destroys the cancer cell.
    Type: Application
    Filed: March 15, 2011
    Publication date: March 21, 2013
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Takafumi Nakamura, Mina Hikichi, Hideaki Tahara, Hisatoshi Shida, Minoru Kidokoro
  • Publication number: 20130071432
    Abstract: One aspect of the present disclosure relates to a method for treating a subject with cancer. The method includes administering an oncolytic virus simultaneously, sequentially, or separately in combination with an immunomodulatory agent in an amount effective to suppress both antiviral immunity and angiogenesis associated with the cancer.
    Type: Application
    Filed: September 18, 2012
    Publication date: March 21, 2013
    Applicant: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Robert Silverman, Babal Kant Jha
  • Patent number: 8398969
    Abstract: The present invention discloses a novel apathogenic viral strain useful in the treatment of viral hepatitis infections. The preferred viral strain of Infectious Bursal Disease Virus (IBDV) is specifically characterized in terms of structure and biological activities. The invention also provides recombinant IBDV viral vectors for the inclusion of exogenous nucleic acid sequences enhancing the viral replication inhibitory effect of the virus of the invention. Preferably, the viral vector comprises a nucleic acid sequence encoding a cytokine. A method of treating viral hepatitis in a host comprising administering an anti-hepatitis effective amount of the IBDV strain of the present invention also provided.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: March 19, 2013
    Assignee: HepC Biotechnológiai Kutató és Fejlesztö Kft.
    Inventors: Tibor Bakács, Imre Kövesdi, Vilmos Palya
  • Publication number: 20130064849
    Abstract: Embodiments of the invention include methods of treating or preventing cardiovascular disease, including atherosclerosis, myocardial infarction, and stroke, by administering an HPV vaccine, particular a vaccine that induces immunity against an oncogenic HPV type such as types 16 and 18.
    Type: Application
    Filed: July 13, 2012
    Publication date: March 14, 2013
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS
    Inventors: Ken Fujise, Hsu-Ko Kuo
  • Patent number: 8394385
    Abstract: The invention is drawn to compositions and methods for the induction of a strong CD8 T cell response to a specific antigen(s). The combination of an early/late hybrid promoter directing strongly enhanced early expression of a neoantigen with at least three immunization rounds resulted in a highly efficient neoantigen-specific CD8 T cell response. This combination reversed the immunodominance hierarchy and converted a moderately immunogenic and subdominant CD8 T cell epitope into the immunodominant epitope.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: March 12, 2013
    Assignee: Bavarian Nordic A/S
    Inventors: Jürgen Hausmann, Karen Baur, Kay Brinkmann
  • Patent number: 8394384
    Abstract: The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: March 12, 2013
    Assignees: Merial Limited, Biolex Therapeutics, Inc.
    Inventors: Xuan Guo, Michel Bublot, Joyce A. Pritchard, Lynn F. Dickey
  • Publication number: 20130058972
    Abstract: The present invention provides a method for modulating the complement cascade by depleting the plasma of the functional activity of complement proteins and thereby reducing or eliminating complement-mediated cell lysis. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated cell lysis and peptide mediators of inflammation. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated diseases. Methods are described herein where complement cascade, triggered by either the classical or alternative complement pathways, is prevented from effecting cell lysis and inflammation due to inhibition or depletion of one or more complement components in the serum following administration of astrovirus coat proteins or derivatives.
    Type: Application
    Filed: July 17, 2012
    Publication date: March 7, 2013
    Applicant: EASTERN VIRGINIA MEDICAL SCHOOL
    Inventors: Neel K. KRISHNA, Kenji CUNNION
  • Patent number: 8388979
    Abstract: Delivery proteins are provided for transferring a protein, antibody or foreign substance into a cell without impairing the function or structure thereof. Further, methods of transferring a foreign substance into a cell at a high efficiency by using the delivery protein or an envelope virus or inactivated envelope virus in combination with said delivery protein are provided. The inventors discovered that a protein containing a polypeptide having an affinity for a constituent of the envelope virus contributes to the efficient enclosure of the foreign substance in the envelope. Moreover, the inventors discovered that use of the delivery protein enables foreign substances to be included in an envelope virus or inactivated envelope virus and therefore makes it possible to efficiently transfer the substances into cells without damaging the physiological function thereof.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: March 5, 2013
    Assignee: Ishihara Sangyo Kaisha, Ltd.
    Inventors: Kuni Fushikida, Yoshitaka Kondo
  • Publication number: 20130052219
    Abstract: A method for producing an ?-Gal-expressing virus having enhanced immune response to viruses, without requiring the use of any enzyme; an influenza virus vaccine having a high effect (antigenicity), which is produced using an ?-Gal-expressing virus produced by the method; and others. Specifically disclosed are: a method for producing an ?-galactose epitope (Gal?1-3Gal?1-4GlcNAc-R: ?-Gal hereinafter)-expressing virus, which comprises the steps of: (1) introducing an ?1,3- galactosyltransferase gene in an expressible condition into a cell line that does not express ?-Gal to obtain a cell line capable of expressing ?-Gal; (2) inoculating a virus into the cell line capable of expressing ?-Gal to obtain a cell line infected with a virus; and (3) culturing the cell line infected with the virus to obtain a virus expressing ?-Gal from the culture medium..
    Type: Application
    Filed: September 30, 2010
    Publication date: February 28, 2013
    Applicants: INCORPORATED ADMINISTRATIVE AGENCY NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION, NATIONAL UNIVERSITY CORPORATION OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE
    Inventors: Haruko Ogawa, Kunitoshi Imai, Takahiro Tagami
  • Publication number: 20130052223
    Abstract: The present invention relates to a universal H5N1 vaccine. More specifically, the present invention relates to the identification of three H5N1 strains which cover the entire variants in the neutralizing epitopes of hemagglutinin among most H5N1 lineages. The present invention further relates a universal H5N1 vaccine that comprises the three H5N1 strains or that comprises hemagglutinin peptides of each of these three strains.
    Type: Application
    Filed: February 9, 2011
    Publication date: February 28, 2013
    Applicant: TEMASEK LIFESCIENCES LABORATORY LIMITED
    Inventors: Prabakaran Mookan, Fang He, Hwei-Sing Jimmy Kwang
  • Patent number: 8383131
    Abstract: A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: February 26, 2013
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Michael Roof, Eric Vaughn, Wesley Johnson
  • Publication number: 20130045267
    Abstract: Methods are provided for modulating expression of claudin-1 and/or claudin-23, for purposes of regulating formation of tight junctions in keratinocytes or other types of cells such as antigen presenting cells (e.g., dendritic cells and Langertians cells), by either increasing or decreasing expression of claudin-1 and/or claudin-23. Also provided are transdermal formulations that decrease expression of claudin-1 and/or claudin-23, thereby diminishing tight junction formation in cells expressing claudin-1 and/or claudin-23, as well as a transdermal patch for delivering the same.
    Type: Application
    Filed: February 7, 2011
    Publication date: February 21, 2013
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Lisa A. Beck, Anna De Benedetto
  • Publication number: 20130039944
    Abstract: Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
    Type: Application
    Filed: April 20, 2011
    Publication date: February 14, 2013
    Applicant: Kineta, Inc.
    Inventors: Shawn P. Iadonato, Kristin Bedard
  • Publication number: 20130039943
    Abstract: A method for inactivating an orthomyxovirus propagated in cell culture and/or inactivating contaminating adventitious agents, comprising at least the following steps: (a) treating an orthomyxovirus-containing fluid with an alkykating agent, and (b) irradiating the orthomyxovirus-containing fluid with UV light.
    Type: Application
    Filed: April 28, 2011
    Publication date: February 14, 2013
    Inventors: Bruno Rene Andre, Benoit Paul Suzanne Champluvier
  • Publication number: 20130039942
    Abstract: The present invention is drawn to compositions and methods to enhance an immune response in order to prevent or treat infections or hyperproliferative diseases such as cancer. More particularly, the composition is an immuno stimulator intracellular signaling peptide fused directly or indirectly to a peptide that leads to multimerization into complexes of three or more units, where the intracelluar signaling peptide must be present in a complex of three or more units in order to stimulate an immune response. Inserting this fusion construct into viruses like HIV-1 or introducing it into dendritic cells or tumor cells is predicted to lead to a positive therapeutic effect in humans, non-human mammals, birds, and fish.
    Type: Application
    Filed: March 22, 2011
    Publication date: February 14, 2013
    Inventors: Richard Syd Kornbluth, Geoffrey William Stone
  • Publication number: 20130039927
    Abstract: The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or induces formation of a broadly neutralizing antibody. Using a fibronectin FNfn10 scaffold bearing two or more modified discontinuous loops, scaffolds that recognize broadly neutralizing antibodies in vitro and from patient serum have been identified. These scaffolds should induce an immune response or mobilize germline specificities to initiate their affinity maturation.
    Type: Application
    Filed: February 14, 2011
    Publication date: February 14, 2013
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Stephen Dewhurst, Mark A. Sullivan
  • Publication number: 20130039945
    Abstract: Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
    Type: Application
    Filed: April 20, 2011
    Publication date: February 14, 2013
    Applicant: Kineta, Inc.
    Inventors: Shawn P. Iadonato, Kristin Bedard
  • Publication number: 20130039958
    Abstract: The present invention relates to improved methods for vaccination of a subject. Particularly, the present invention discloses the use of skin antigen application to amplify and improve a pre-existing immunity against a selected pathogen in a subject. The present invention discloses the use of skin application in combination with conventional vaccination or priming for improved immunization or vaccination of a subject against a selected pathogen.
    Type: Application
    Filed: October 12, 2012
    Publication date: February 14, 2013
    Applicant: DBV TECHNOLOGIES
    Inventor: DBV TECHNOLOGIES
  • Patent number: 8372963
    Abstract: The present invention relates to a nucleic acid molecule, which codes for the F-protein of the respiratory syncytial virus (RSV) or a fragment thereof, for the expression in a human cell environment of codon optimized variants of said nucleic acid molecule, vectors and compositions comprising said nucleic acid molecules and the use thereof as vaccines and polypeptides coded by the nucleic acid molecules and method for the production thereof.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: February 12, 2013
    Assignees: Pevion Biotech AG, Ruhr-Universitaet Bochum
    Inventors: Thomas Grunwald, Klaus Ueberla
  • Patent number: 8367327
    Abstract: A multiplex PCR assay for simultaneously detecting biological threat agents whose genome is DNA or RNA, by using computational tools to identify a specific target sequence which is unique to a specific genus or species of organism and is also a conserved sequence within that group, selecting specific primer sets, creating a probe to label the target nucleic acid, extracting the target nucleic acid from a sample, amplifying the targeted nucleic acid to detectible levels and reading the presence or absence of the target nucleic acid simultaneously from all threat agents.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: February 5, 2013
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Jose-Luis Sagripanti, Monica Carrera Zandomeni
  • Patent number: 8367069
    Abstract: The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, cell comprising the vector, and compositions thereof. The invention also provides a method of inducing a T-cell response in a patient with epithelial cancer, and a method inhibiting epithelial cancer, wherein the methods comprise administering the composition of the invention. The invention further provides a method of stimulating a cell with the inventive polypeptide and a cell so stimulated.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: February 5, 2013
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Robert L. Ferris, Pedro Andrade, Andres Lopez-Albaitero
  • Patent number: 8367068
    Abstract: A method to induce an immune response in a host in need thereof, comprises administering to the host, recombinant lentiviral vector particles comprising: a) a GAG polypeptide or a functional GAG-polypeptide derivative; b) a POL polypeptide or a functional POL-polypeptide derivative ; c) an ENV polypeptide or a functional ENV-polypeptide derivative; and d) a recombinant polynucleotide. The recombinant polynucleotide comprises a transgene placed under the control of regulatory signals for transcription and expression, regulatory signals, of lentiviral origin, for reverse transcription, expression and packaging, and a polynucleotide comprising a cis-acting central initiation region (cPPT) and a cis-acting termination region (CTS). The regions are of lentiviral origin and are inserted in a functional orientation with the regulatory signals of lentiviral origin. The polynucleotide forms a DNA triplex during reverse transcription.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: February 5, 2013
    Assignees: Institut Pasteur, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique
    Inventors: Pierre Charneau, Véronique Zennou, Hüseyin Firat
  • Publication number: 20130028931
    Abstract: The present invention relates to the field of attenuated live viruses useful as vaccine or medicament for preventing or treating Porcine Reproductive and Respiratory Syndrome (PRRS) in swine, and is based on the surprising finding of a PRRS virus which is able to induce the interferon type I response of a cell infected by said virus. In one embodiment, the PRRS virus according to the invention is a PRRS virus mutant comprising, in comparison with the genome of a wild type strain, a mutation in the gene encoding the non structural protein 1 (nsp1) of said virus.
    Type: Application
    Filed: July 26, 2012
    Publication date: January 31, 2013
    Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventor: Andreas GALLEI
  • Publication number: 20130028932
    Abstract: The present invention provides pharmaceutical compositions comprising an immunostimulatory polypeptide and polyglutamic acid (PGA) nanoparticles, formulated in a pharmaceutically acceptable diluent, carrier or excipient. Such compositions have utility in stimulating the immune system in subjects, with the components capable of interacting synergistically. The invention further provides uses of the compositions of the invention, for example in the treatment of cancer, and kit and components for use in the same.
    Type: Application
    Filed: April 13, 2011
    Publication date: January 31, 2013
    Applicant: Alligator Bioscience AB
    Inventors: Carl Arne Krister Borrebaeck, Sissela Rachel Linn Broos, Peter Bo Joakim Ellmark, Malin Marie Lindstedt
  • Patent number: 8361483
    Abstract: A method of enhancing a mammalian immune response to a virus is disclosed. The method comprises administering a composition comprising an effective amount of epinecidin (Epi)-1 and the virus to a mammal, wherein the virus has envelope protein and is infectious to the mammal. A vaccine kit and a method for preventing Japanese encephalitis virus (JEV) infection are also disclosed.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: January 29, 2013
    Assignee: Academia Sinica
    Inventors: Jyh-Yih Chen, Chang-Jer Wu
  • Publication number: 20130022602
    Abstract: The invention is directed to an improved method to manufacture virus for use in vaccine by culturing infected cells that have been modified to overexpress miR-144. The invention is also directed to manipulating the activity or level of miR-144 in subjects in order to modulate the antiviral and immune response systems.
    Type: Application
    Filed: July 5, 2012
    Publication date: January 24, 2013
    Inventors: Carrie M. Rosenberger, Alan A. Aderem
  • Patent number: 8357363
    Abstract: The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: January 22, 2013
    Assignee: Aicuris GmbH & Co. KG
    Inventors: Olaf Weber, Sonja Maria Friederichs, Angela Siegling, Tobias Schlapp, Andrew Allan Mercer, Stephen Bruce Fleming, Hans-Dieter Volk
  • Patent number: 8354115
    Abstract: The present invention provides methods and adjuvants for enhancing an immune response to RSV in a host, wherein the methods and adjuvants comprise a source of a CD40 binding protein. Preferably, the CD40 binding protein is CD40L and the source is a vector comprising a promoter operatively linked to a CD40L coding region. The enhanced immune response produced by the adjuvants and methods of the current invention includes both increased expression of Th1 cytokines and increased production of antibody.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: January 15, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventors: Ralph A. Tripp, Larry J. Anderson, Michael P. Brown
  • Publication number: 20130011434
    Abstract: A method for preparing an injectable vaccine composition intended to combat porcine reproductive and respiratory syndrome (PRRS), includes at least the step in which: a) a live vaccine is mixed extemporaneously with an adjuvant diluent (AD). The adjuvant diluent is an oil-in-water-type emulsion or an oil-in-water-type microemulsion, or an aqueous solution including water and at least one inorganic salt selected from aluminum hydroxide, cerium nitrate, zinc sulfate, colloidal iron hydroxide or calcium chloride, salts of divalent or trivalent metals or sympathomimetic compounds.
    Type: Application
    Filed: March 15, 2011
    Publication date: January 10, 2013
    Applicant: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventors: Francois Bertrand, Sebastien Deville, Laurent Dupuis
  • Patent number: 8349606
    Abstract: The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: January 8, 2013
    Assignees: Institut Pasteur, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique
    Inventors: Pierre Charneau, Hüseyin Firat, Véronique Zennou
  • Publication number: 20130004529
    Abstract: Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.
    Type: Application
    Filed: April 27, 2012
    Publication date: January 3, 2013
    Inventors: David B. Weiner, Jian Yan, Dominick Laddy
  • Patent number: 8343505
    Abstract: An aquatic subunit vaccine comprises an antigenic fusion protein and suitable carrier or adjuvant. The antigenic fusion protein sequence consists from its amino terminus to carboxyl terminus of a receptor binding motif and a translocation domain of Pseudomonas aeruginosa exotoxin A and has the amino acid sequence of SEQ ID No: 8; a viral antigenic protein affecting fish disease; and a signal peptide having the amino acid sequence of SEQ ID No: 10.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: January 1, 2013
    Assignee: Schweitzer Co., Ltd.
    Inventors: Tsunyung Kuo, Gabriel Hsuchung Chen, Chungchin Wu, Oystein Evensen, Inderjit Singh Marjara
  • Publication number: 20120328655
    Abstract: Compositions and methods are provided herein for improved dual immunization strategies that induce in a subject an immune response that includes a humoral immune response and cellular immune response, both CD4 and CD8 T lymphocyte immune responses, thereby providing a complete adaptive immune response to one or more antigens. The methods described are therefore useful for treating and/or preventing (i.e., reducing the likelihood or risk of occurrence) different diseases, disorders, and conditions such as cancers and infectious diseases for which induction of both a humoral immune response and cellular immune response is desired and beneficial.
    Type: Application
    Filed: April 6, 2012
    Publication date: December 27, 2012
    Applicant: IMMUNE DESIGN CORP.
    Inventors: Thomas W. Dubensky, JR., Scott H. Robbins
  • Patent number: 8337859
    Abstract: The present invention provides a vector for expressing at least a first and a second nucleic acid molecules which exhibit a percentage of homology of approximately 80% or greater than 80% over a portion of 40 or more continuous nucleotides and wherein said first nucleic acid molecule and/or said second nucleic acid molecule is modified so as to reduce said percentage of homology to less than 75%. The present invention also relates to substantially isolated nucleic acid molecules comprising a nucleotide sequence as defined in any of SEQ ID NO: 9-15 and 66-69. It also provides a host cell and a pharmaceutical composition comprising such a nucleic acid molecule or vector as well as their use for therapeutic or preventive purposes.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: December 25, 2012
    Assignee: Transgene S.A.
    Inventors: Nathalie Silvestre, Doris Schmitt
  • Publication number: 20120321664
    Abstract: Disclosed are methods to modulate yeast-based immunotherapy products and the immune responses, prophylactic responses, and/or therapeutic responses elicited by such products. Also disclosed are modified yeast-based immunotherapy products, kits and compositions.
    Type: Application
    Filed: September 14, 2010
    Publication date: December 20, 2012
    Inventors: Donald Bellgrau, Beth Tamburini
  • Patent number: 8333975
    Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 18, 2012
    Assignee: Medimmune, LLC
    Inventors: Chin-Fen Yang, George Kemble, Chongguang Liu
  • Publication number: 20120315294
    Abstract: The invention provides novel methods and compositions for the vaccination of porcine animals against porcine reproductive and respiratory syndrome virus (PRRSV). Described herein are immunological and/or vaccine compositions comprising a DNA vector encoding a PRRSV protein, particularly a truncated ORF7 protein, which are administered to porcines using needle-free delivery. The plasmid can include more than one nucleic acid molecule such that the plasmid can express more than one antigen. Also disclosed are methods for using and kits employing such compositions.
    Type: Application
    Filed: May 24, 2012
    Publication date: December 13, 2012
    Inventors: Sanipa Suradhat, Jean-Christophe Audonnet, Catherine Charreyre
  • Publication number: 20120308618
    Abstract: The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 ?m.
    Type: Application
    Filed: February 21, 2011
    Publication date: December 6, 2012
    Applicant: Intercell AG
    Inventors: Benjamin Wizel, Karin Riedl, Karen Lingnau, Ursula Schlosser, Jürgen Wruss, Robert Schlegl, Michael Weber, Christoph Reinisch, Ljubomir Paucz, Christoph Klade, Jee Loon Look, Christian Ruiz, Robert Seid
  • Publication number: 20120308592
    Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of human papillomavirus (HPV) infections and related disorders, including cervical cancer and persistent infections associated with HPV. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against HPV infection, confer immunity against HPV infection, protect against HPV infection, and reduce the likelihood of infection by HPV infection.
    Type: Application
    Filed: February 8, 2011
    Publication date: December 6, 2012
    Applicant: STC.UNM
    Inventors: Bryce Chackerian, David S. Peabody
  • Patent number: 8323663
    Abstract: The invention is directed to an adenoviral vector comprising at least one nucleic acid sequence encoding an aphthovirus antigen and/or a cytokine operably linked to a promoter. The adenoviral vector is replication-deficient and requires at most complementation of both the E1 region and the E4 region of the adenoviral genome for propagation. The invention also is directed to a method of inducing an immune response in a mammal comprising administering to the mammal a composition comprising the aforementioned adenoviral vector.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: December 4, 2012
    Assignee: GenVec, Inc.
    Inventors: Douglas E. Brough, Joseph T. Bruder, C. Richter King, Marvin J. Grubman, John G. Neilan
  • Patent number: 8323658
    Abstract: Antigenic isolates and vaccines for Infectious Bursal Disease Virus include variants of the molecular Group 6 family of IBDV isolates, in particular the 28-1 isolate.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: December 4, 2012
    Assignee: PAH W LLC
    Inventors: Jeffrey Harold Rodenberg, Mahesh Kumar, Kalen Cookson
  • Patent number: 8313750
    Abstract: The invention provides a new type of a capsid protein VP1 of human enterovirus 71, named as MEL701-VP1 and functional/structural variants thereof, which is used for protection against enterovirus. The transgenic animal producing the protein, the composition comprising the protein and the method for production thereof are also provided.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: November 20, 2012
    Assignee: National Chung Hsing University
    Inventors: Chuan-Mu Chen, Hsiao-Ling Chen
  • Patent number: 8313897
    Abstract: A method for preserving viral particles comprises: (i) providing an aqueous solution of one or more sugars, a polyethyleneimine and said viral particles wherein the concentration of polyethyleneimine is 15 ?M or less based on the number-average molar mass (Mn) of the polyethyleneimine and the sugar concentration or, if more than one sugar is present, total sugar concentration is greater than 0.1 M; and (ii) drying the solution to form an amorphous solid matrix comprising said viral particles.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: November 20, 2012
    Assignee: Stabilitech Ltd.
    Inventor: Jeffrey Drew
  • Publication number: 20120288552
    Abstract: The invention relates to a composition comprising a pharmaceutically active agent and a bioadhesive delivery system that provides for the oral delivery of a vaccine to animals, particularly aquatic animals.
    Type: Application
    Filed: May 8, 2012
    Publication date: November 15, 2012
    Inventors: MOTI HAREL, BRIAN CARPENTER