Eimeria Patents (Class 424/267.1)
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Patent number: 8257714Abstract: The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.Type: GrantFiled: April 14, 2008Date of Patent: September 4, 2012Assignee: Michigan State UniversityInventors: Charles Aylsworth, Siu-Cheong Ho, David Juckett, John W. Judge, Barnett Rosenberg, Igor V. Zlatkin, Tatiana Zlatkin
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Patent number: 8252292Abstract: The present invention discloses a vaccine that provides protection to turkeys from coccidiosis, and methods of making and using the vaccine alone, or in combinations with other protective agents. In addition, the present invention discloses PCR primer sets that are useful in identifying the species of Eimeria in a biological sample.Type: GrantFiled: November 11, 2009Date of Patent: August 28, 2012Assignees: Intervet International B.V., Intervet Inc.Inventors: Steve Hewart Fitz-Coy, Gamini Saman Kumara Withanage, Alexandria Louise McGowan, Stephanie M. Cook
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Patent number: 8110188Abstract: The invention refers to anticoccidial compositions consisting mainly of yolk immunoglobulins derived from eggs of hens immunized with one or more Eimeria species. The invention refers also to the use of said anticoccidial compositions for prevention or treatment of coccidiosis. The administration of immunoglobulins, both in liquid as well as in powder or pellet presentation, decreases mortality, lesions, oocysts counts and increases weight gain of receiving animals.Type: GrantFiled: September 30, 2005Date of Patent: February 7, 2012Assignee: Investigacion Aplicada, S.A. de C.V.Inventors: Jose Andres Morales Garzon, Eduardo Lucio Decanini
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Patent number: 7722877Abstract: The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.Type: GrantFiled: November 7, 2006Date of Patent: May 25, 2010Assignee: Intervet International B.V.Inventors: Theodorus Cornelis Schaap, Catharina Maria Kuiper, Arnoldus Nicolaas Vermeulen
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Patent number: 7638131Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.Type: GrantFiled: May 2, 2007Date of Patent: December 29, 2009Assignee: Intervet International B.V.Inventors: Jacobus Johannes Kok, Paul van den Boogaart, Arnodus Nicolaas Vermeulen
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Publication number: 20090196888Abstract: The present invention provides the recombinant cloning and sequencing of two of the major Eimeria maxima gametocyte antigens having molecular weights of 56 and 82 kDa and the expression of these recombinant antigens in an E. coli expression system using the plasmid pTrcHis. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen. The subject invention also provides two 30 kDa proteins and three 14 kDa proteins from Eimeria maxima gametocytes having at the N-terminal end the amino acid sequence described herein. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen and any of the aforementioned proteins.Type: ApplicationFiled: May 30, 2008Publication date: August 6, 2009Inventors: Sabina I. Belli, Nicholas C. Smith, Michael Wallach
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Methods of treating or preventing a disease, disorder or condition associated with a viral infection
Patent number: 7550150Abstract: The present invention relates to methods of treating or preventing a disease, disorder or condition associated with a viral infection using a dosing and resting regimen for administering a pharmaceutical composition that provides ARP.Type: GrantFiled: March 14, 2006Date of Patent: June 23, 2009Assignee: Barros Research InstituteInventors: Barnett Rosenberg, John W. Judge -
Publication number: 20080233138Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.Type: ApplicationFiled: May 2, 2007Publication date: September 25, 2008Applicant: Intervet International B.V.Inventors: Jacobus Johannes Kok, Paul van den Boogaart, Arnodus Nicolaas Vermeulen
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Patent number: 7354593Abstract: The present invention relates to a vaccine for coccidiosis in chickens prepared from three attenuated Eimeria species: E. acervulina, E. maxima and E. tenella. The vaccine was similar to or superior to other anticoccidial drugs in stimulating protective immunity against coccidiosis.Type: GrantFiled: February 6, 2006Date of Patent: April 8, 2008Assignees: Merial Limited, University of Georgia Research Foundation, Inc.Inventors: Larry R. McDougald, Alberta Lorraine Fuller, Joyce Anita Pritchard
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Patent number: 7247309Abstract: The present invention relates to coccidia strains and, in one embodiment, to microbiological cultures comprising such strains. In preferred embodiments, the coccidia strains are selected for tolerance to one group of coccidiostatic drugs, sensitivity to a second group of coccidiostatic drugs, and decreased proliferative capacity. Another embodiment of the invention relates to vaccines based on the coccidia strains according to the invention.Type: GrantFiled: December 18, 2000Date of Patent: July 24, 2007Assignee: Intervet International B.V.Inventors: Arnoldus Nicolaas Vermeulen, Theodorus Petrus Maria Schetters
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Patent number: 7230075Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.Type: GrantFiled: September 14, 1999Date of Patent: June 12, 2007Assignee: Intervet International B.V.Inventors: Jacobus Johannes Kok, Paul van den Boogaart, Arnodus Nicolaas Vermeulen
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Patent number: 7150873Abstract: The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.Type: GrantFiled: November 26, 2003Date of Patent: December 19, 2006Assignee: Intervet International B.V.Inventors: Theodorus Cornelis Schaap, Catharina Maria Kuiper, Arnoldus Nicolaas Vermeulen
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Patent number: 7018640Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immnunizing dose of live Eimeria sporozoites or merozoites, or a mixture thereof. In a preferred embodiment, the domesticated bird that is vaccinated is a chicken or turkey.Type: GrantFiled: March 8, 2002Date of Patent: March 28, 2006Assignee: Pfizer IncorporatedInventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Patent number: 6998126Abstract: A method for obtaining an immunogenic strain useful for producing a vaccine against Coccidiosis comprises the cycle of infecting at least one first group of specific pathogen-free donor birds with oocysts from an Eimeria species. Blood is then collected from these donor birds, and is then used to infect a second group of specific pathogen-free birds. Oocysts are collected from the second group of birds. These oocysts are then multiplicated to complete the cycle. The cycle is then repeated using the multiplicated oocysts. After a total of about three cycles, a final antigen may be harvested and utilized as a source to generate oocysts for a vaccine.Type: GrantFiled: February 21, 2003Date of Patent: February 14, 2006Assignee: WyethInventor: Frans Gerrit Davelaar
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Patent number: 6998127Abstract: The present invention relates to a vaccine for coccidiosis in chickens prepared from four attenuated Eimeria species: E. acervulina, E. maxima, E. mitis and E. tenella. The vaccine was similar to or superior to other anticoccidial drugs in stimulating protective immunity against coccidiosis.Type: GrantFiled: April 15, 2005Date of Patent: February 14, 2006Assignee: Merial LimitedInventors: Larry R. McDougald, Alberta L. Fuller
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Patent number: 6908620Abstract: The present invention relates to a vaccine for coccidiosis in chickens prepared from four attenuated Eimeria species: E. acervulina, E. maxima, E. mitis and E. tenella. The vaccine was similar to or superior to other anticoccidial drugs in stimulating protective immunity against coccidiosis.Type: GrantFiled: December 8, 2003Date of Patent: June 21, 2005Assignee: University of Georgia Research Foundation, Inc.Inventors: Larry R. McDougald, Alberta L. Fuller
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Patent number: 6790937Abstract: The present invention relates to (a) variable regions of heavy and light chains of an antibody specific to a surface antigen in sporozoite of Eimeria spp.; (b) a recombinant scFV (single chain variable fragment) antibody prepared using the variable regions; (c) a method for preparing a recombinant scFv antibody; and (d) an expression vector for expressing a recombinant scFv antibody.Type: GrantFiled: February 26, 2002Date of Patent: September 14, 2004Assignee: Avicore Biotechnology Institute Inc.Inventors: Jin-Kyoo Kim, Jae-Yong Han, Ki-Duck Song, Sung-Won Kim, Won-Gi Min, Eun-Jung Son, Hyun Soon Lillehoj, Erik Peter Lillehoj
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Patent number: 6767546Abstract: Echinacea dietary supplements are useful adjuvants for live anticoccidial vaccines. Feed supplementation with Echinacea preparations enhances the immune response to such vaccines. Echinacea purpurea in amounts of about 0.1% to 0.5% administered for about two weeks to day-old chicks has been found effective for providing significant weight gain compared to vaccination alone.Type: GrantFiled: August 17, 2001Date of Patent: July 27, 2004Assignees: The United States of America as represented by the Secretary of Agriculture, Triarco Industries, Inc.Inventors: Patricia C. Allen, Mark Anderson, Harry D. Danforth
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Patent number: 6680061Abstract: The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.Type: GrantFiled: December 27, 2000Date of Patent: January 20, 2004Inventors: Theodorus Cornelis Schaap, Catharina Maria Kuiper, Arnoldus Nicolaas Vermeulen
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Patent number: 6627205Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporocysts or oocysts, or a mixture thereof.Type: GrantFiled: March 8, 2002Date of Patent: September 30, 2003Assignee: Pfizer IncorporatedInventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Publication number: 20030170277Abstract: A method for obtaining an immunogenic strain useful for producing a vaccine against Coccidiosis comprises the cycle of infecting at least one first group of specific pathogen-free donor birds with oocysts from an Eimeria species. Blood is then collected from these donor birds, and is then used to infect a second group of specific pathogen-free birds. Oocysts are collected from the second group of birds. These oocysts are then multiplicated to complete the cycle. The cycle is then repeated using the multiplicated oocysts. After a total of about three cycles, a final antigen may be harvested and utilized as a source to generate oocysts for a vaccine.Type: ApplicationFiled: February 21, 2003Publication date: September 11, 2003Applicant: WyethInventor: Frans Gerrit Davelaar
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Patent number: 6495146Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporocysts or oocysts, or a mixture thereof.Type: GrantFiled: December 1, 1997Date of Patent: December 17, 2002Assignee: Pfizer IncorporatedInventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Publication number: 20020146435Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immnunizing dose of live Eimeria sporozoites or merozoites, or a mixture thereof. In a preferred embodiment, the domesticated bird that is vaccinated is a chicken or turkey.Type: ApplicationFiled: March 8, 2002Publication date: October 10, 2002Inventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Publication number: 20020090378Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporocysts or oocysts, or a mixture thereof.Type: ApplicationFiled: March 8, 2002Publication date: July 11, 2002Inventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Publication number: 20020031530Abstract: The Invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ova an effective itmmunwning dose of live Ekneria sporozoites or merozoites, or a mixture thereof. In a preferred embodiment, the domesticated bird that is vaccinated is a chicken or turkey.Type: ApplicationFiled: December 1, 1997Publication date: March 14, 2002Inventors: NIGEL A EVANS, ROBERT CRAIG FINDLY, FREDERICK H. WEBER
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Patent number: 6203801Abstract: The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.Type: GrantFiled: October 4, 1999Date of Patent: March 20, 2001Assignee: Akzo Nobel N.V.Inventors: Theodorus Cornelis Schaap, Catharina Maria Kuiper, Arnoldus Nicolaas Vermeulen