Plasmodium Patents (Class 424/272.1)
  • Cloning and expression of plasmodium falciparum transmission-blocking target antigen, PFS230
    Patent number: 6316000
    Abstract: Compositions comprising biologically pure Pfs230 and nucleic acids which encode them are provided. The proteins can be used induce transmission blocking immune responses in susceptible hosts.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: November 13, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kim C. Williamson, David C. Kaslow
  • Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
    Patent number: 6270771
    Abstract: The invention discloses a molecule or polypeptide composition characterized by the presence in its structure of one or more peptide sequences bearing all or part of one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of proteins resulting from the infectious activity of P. Falciparum in hepatic cells. Also disclosed is the use of these molecules in tests, and a kit for in vitro diagnosis of paludism from a biological sample from the individual in whom the disease is to be detected.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: August 7, 2001
    Assignee: Institut Pasteur
    Inventors: Claudine Guerin-Marchand, Pierre Druilhe
  • Malaria recombinant poxvirus vaccine
    Patent number: 6214353
    Abstract: What is described is a recombinant poxvirus, such as vaccinia virus, containing foreign DNA from Plasmodium Merozoite Surface Antigen 1. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: April 10, 2001
    Assignees: Pasteur Merieux Serums et Vaccins, The University of Hawaii
    Inventors: Enzo Paoletti, Charles de Taisne, Sandra Chang, George Hui, Wasim A. Siddigui
  • Treatment of diabetes
    Patent number: 6214357
    Abstract: The present invention provides methods for using a killed malaria parasite or an extract thereof in the treatment of non-insulin dependent diabetes mellitus (NIDDM).
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: April 10, 2001
    Assignee: Rademacher Group Limited
    Inventors: John Hugh Lyon Playfair, Khaled Elased, Joseph Brian De Souza