Abstract: Formulation of ectoparasiticidal and antibiotic “compositions into pharmaceutical compositions useful for the treatment of eyelid inflammation, in particular demodex related blepharitis and eye crusting.

Abstract: Described herein are personal care compositions comprising a solid vinylpyrrolidone/vinyl acetate copolymer; a vinylpyrrolidone/vinyl acetate copolymer; and a cosmetically acceptable carrier. Methods of making and using the same are also described.

Abstract: The present disclosure relates to leave-on penetrating oil hair compositions that comprise a blend of non-cyclic silicone and non-silicone ingredients. The leave-on penetrating oil hair compositions, which do not contain D4, D5 or D6 silicones, are particularly useful in methods for imparting durable resistance to breaking, frizz control, shine and/or volume definition with a soft feel to hair.

Abstract: Various techniques pertain to a user interface that includes an instructional display portion comprising one or more textual or graphical instructions pertaining to preparing for a body scan for body care of a client and a scan initiation display portion that includes a scan initiation widget which, when interacted by the client, invokes execution of a scan process and an analysis process for a respective body area of the client. The user interface further includes a scan result display portion including interactable textual or graphical information pertaining to a result of the body scan for the body care and an adjustment display portion having a plurality of adjustment widgets that transform at least a color index or value into a transformed color index or value in a L*A*B* color space or a Lch color space.

Abstract: A non-surfactant type oil-water (O/W) dispersion composition containing non-polar solvent droplets in a polar solvent, of which transparency is 90-100%, and a non-surfactant type water-oil (W/O) dispersion composition containing polar solvent droplets in a non-polar solvent, of which transparency is 90-100% are disclosed. Also disclosed are methods for manufacturing methods for both of the compositions.

Abstract: The present invention relates to sunscreen or daily care compositions comprising butyl methoxydibenzoylmethane, at least one UV filter selected from triazine derivatives, at least one photostabilizer selected from butyl octyl salicylate, benzotriazolyl dodecyl p cresol, ethyl hexyl methoxycrylene, polyester-8, diethyl hexyl syringylidenemalonate, trimethoxybenzylidene pentanedione, diethylhexyl 2,6-naphthalate, a fused ring cyanoacrylate derivative and polyester-25, wherein the composition does not comprise octocrylene and ethyl hexyl methoxy cinnamate.

Abstract: Disclosed herein are surfactant peptide nanostructures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostructures are useful for therapeutic applications, including for delivery of drugs and siRNA.

Abstract: The present disclosure relates to leave-on serum hair compositions that comprise a blend of non-cyclic silicone and non-silicone ingredients. The leave-on serum hair compositions, which do not contain D4, D5 or D6 silicones, are particularly useful in methods for imparting durable resistance to breaking, frizz control, shine and/or volume definition with a soft feel to hair.

Abstract: Novel compounds able to absorb UV radiation and comprise antimicrobial properties as well. The compounds are novel and undisclosed scytonemin analogs, able to absorb up to 90% of UV-A radiation and can cover a broader UV to blue light absorption range from 293 nm to 500 nm. When mixtures of more than one compound are used, their synergetic absorption properties can cover an even broader spectrum within 293 nm to 500 nm. The compounds present faint coloration, and some are even colorless, therefor the present compounds can be easily incorporated in formulations to be used in cosmetic products, sunscreens or lenses for sunglasses.

Abstract: Cosmetic formulation with deodorant activity for topical application including vitamin E or an ester thereof, starch, sodium bicarbonate, zinc oxide and a cosmetically acceptable carrier is disclosed. The vitamin E ester is preferably alpha-tocopherol acetate, n-propionate or linoleate and the vitamin E or ester thereof and is present in an amount of 5-40% by weight of the weight of the formulation.

Abstract: The present invention relates to a sensory emulsifying composition, in particular for cosmetic use, capable of obtaining a liquid oil-in-water-type emulsion comprising at least one cyclodextrin in the form of solid particles, said particles having a volumetric average particle size d(4,3), measured by laser granulometry, of between 2 and 20 ?m, preferably between 3 and 12 ?m, and more preferably between 4 and 8 ?m, and at least one emulsifier of natural origin selected from water-in-oil emulsifiers, having a hydrophilic-lipophilic balance (HLB) of less than 8.

Abstract: Disclosed are: a method for suppressing adhesion of air harmful substances, including applying a metal oxide (A) having an average primary particle diameter dA of 800 nm or less to skin in an amount of 0.03 mg/cm2 or more to suppress adhesion of air pollutants to the skin, and a method for suppressing adhesion of air pollutants, including applying an external preparation to skin to suppress adhesion of air pollutants to the skin, wherein the external preparation contains the component (AI), and the component (BI), the component (BII) or the component (BIII), and the ratio by mass of the content of the component (BI), the component (BII) or the component (BIII) to the content of the component (AI) in the external preparation each falls within a specific range. Component (AI): a hydrophobized metal oxide having an average primary particle diameter dAI of 800 nm or less. Component (BI): an ester oil. Component (BII): a nonvolatile hydrocarbon oil. Component (BIII): a nonvolatile silicone oil.

Abstract: The instant disclosure relates to oil-in-water compositions comprising: (i) compound of thiopyridinone type; (ii) a blend of natural emulsifiers; wherein the oil-in-water cosmetic composition is physically stable.

Abstract: The present invention relates to cosmetic compositions which comprise a hyperbranched copolymer of the monomers dodecenyl succinic acid anhydride, diisopropanol amine and bis-dimethylaminopropyl amine having quaternary terminal groups and a liquid and/or solid organic UV-filter. The copolymer is used in a cosmetic composition comprising the UV-filter for reducing the material transfer to a contacted surface. Preferably the copolymer is polyquatemium-110.

Abstract: A method comprising topically applying to skin a composition comprising an aqueous, alcoholic, or aqueous-alcoholic extract from Ipomoea batatas.

Abstract: A method and composition for promoting hair growth comprises an oil solution created with predetermined quantities of certain oils such as sesame oil, avocado oil, sweet almond oil, coconut oil, and ricinus oil. A blended final product is created by adding predetermined quantities of certain plants to the oil solution, such as parsley and aloe vera. The final product is heated and applied to a surface for hair growth. After a certain amount of time it is washed off the surface for hair growth. These steps are repeated daily for a full course of treatment, which comprises a few weeks. The course may be repeated about every other month.

Abstract: Methods for manufacturing universal mineral based sunscreens that is good for all skin colors and prevents any ashy visual appearance on all colors of skin, is provided in this invention.

Abstract: The hydrogel of the present invention is a hydrogel comprising a polymer matrix, water and a plasticizer, wherein the hydrogel is characterized in that the plasticizer loss ratio is less than 2, the swelling rate is 115% or less when the hydrogel is exposed to the environment of 40° C. and 90% RH for 1 hour, and the initial adhesive force to a Bakelite plate is 100 gf/20 mm or more in the environment of 23° C. and 55% RH. The plasticizer is preferably polyoxyalkylene alkyl ether and/or sugar. The initial high adhesive force is retained by suppressing the swelling of the gel due to invasion of water from the outside and reducing the loss of a plasticizer.

Abstract: The present invention relates generally to methods of use and compositions useful to reduce the appearance of uneven skin tone, reduce the appearance of skin discoloration, reduce visible skin discoloration, improve the appearance of uneven skin tone, improve the brightness of skin, prevent the production of discoloration, limit uneven skin tone from appearing on skin, increase moisture levels, attract water, brighten, renew the skin, increase skin radiance, soothe the skin, increase skin smoothness, hydrate skin, smooth skin, brighten skin, reduce signs of aging in skin, and/or increase the efficacy of cosmetic products to brighten, renew the skin, increase skin radiance, sooth the skin, increase skin smoothness, hydrate skin, smooth skin, brighten skin, and/or reduce signs of aging in skin. The composition includes a combination of niacinamide, vegetable amino acids, and ferulic acid.

Abstract: Provided is an inorganic powder composite used for a water-in-oil type fine dispersion system which is excellent in emulsification and emulsification stability. The inorganic powder composite includes: an inorganic powder; and a first hydrophobic treatment agent, a second hydrophobic treatment agent, and a hydrophilic treatment agent, which cover at least one part of a surface of the inorganic powder, the first hydrophobic treatment agent is a silicon compound, the second hydrophobic treatment agent is a fatty acid, and the hydrophilic treatment agent is hydrous silica.

Abstract: An organic counteranion co-assembly strategy is employed to prepare a hybrid molecular framework. The hybrid molecular framework comprises an ordered arrangement of cyclodextrin (CD), metal cations, and organic anions.

Abstract: Disclosed is an oleic acid derivative including a hydrophobic part C17H33 linked to a particular polar head part “A”, especially for use as a medicament, for instance, for the treatment of a disorder caused by the GPR120 receptor and/or the CD36 receptor, including administering to a subject in need thereof a therapeutically effective amount of the oleic acid derivative or of the pharmaceutical composition. Also disclosed is the use of the oleic acid derivative as a food composition.

Abstract: Compositions comprising UV blocking agents, a film forming polymer containing acid groups and a neutralizing agent; compositions and methods for increasing the SPF of a composition by neutralizing at least a portion of the acid groups of the film forming agent with the neutralizing agent.

Abstract: The present disclosure relates to a composition for inhibiting neurotransmitter secretion by inhibiting membrane potential generation of the nerve. The composition of the present disclosure has a synergistic effect related to inhibition of SNARE complex formation, and thereby, it can prevent active secretion of neurotransmitters, and thus can reduce muscle contraction to improve skin wrinkles.

Abstract: The present application relates to encapsulated benefit agents, compositions comprising such encapsulated benefit agents and processes for making and using compositions comprising such encapsulated benefit agents. Such encapsulated benefit agents eliminate or minimize one or more of the drawbacks of current encapsulated benefit agents and thus provide formulators with additional perfume delivery opportunities.

Abstract: A personal care formulation is provided comprising: multistage polymer, comprising: acrylate rich stage comprising: (a) structural units of monoethylenically unsaturated non-ionic, acrylate rich stage monomer selected from C1-22 alkyl (meth)acrylates and mixtures thereof; and (b) carbosiloxane rich stage, comprising: structural units of carbosiloxane monomer of formula (I), wherein a is 0 to 3; wherein d is 0 or 1; wherein R1 is selected from hydrogen, C1-10 alkyl group and aryl group; wherein R2 is selected from hydrogen and C1-10 alkyl group; wherein R8 is —O—Si(CH3)2—O—Si(CH3)3 group; wherein Y is selected from formula (II), (III) and (IV); wherein R4 and R6 are selected from hydrogen and methyl group; wherein R3 and R5 are a C1-10 alkylene group; wherein R7 is C1-10 alkyl group; wherein b is 0 to 4 and wherein c is 0 or 1.

Abstract: A device for detecting exposure to light includes: a photo-responsive layer including a photochromic material; a skin-mimicking cover layer covering a first side of the photo-responsive layer; and an adhesive layer configured to couple a second side of the photo-responsive layer opposite the first side to a surface.

Abstract: Provided, inter alia, are synthetic melanin nanoparticles (MelNPs) useful for protecting keratinocytes from UV-damage and for treating melanin-defective diseases.

Abstract: A deodorant composition comprising a compound containing an aryl group and exhibiting an acidic property, a carrier, and an optional compatibilizing agent.

Abstract: The instant disclosure relates to a cosmetic composition containing high amounts of lactone polyols and to methods for treating skin with the compositions. The cosmetic compositions include: (a) poly C10-30 alkyl acrylate; (b) at least 5 wt. % of one or more lactone polyols; (c) one or more nonionic emulsifiers; (d) one or more fatty compounds; and (e) water. In addition, the amount of the one or more lactone polyols in the composition is typically at least 10-fold higher than the amount of the poly C10-30 alkyl acrylate in the composition.

Abstract: The present invention relates to a fluid composition intended for the protection of keratin materials against ultraviolet radiation, characterized in that it comprises at least: (a) a photoprotective system capable of screening out UV radiation, (b) at least one diester of a C2-C8 carboxylic acid and of a C1-C4 alcohol, (c) at least one diester of a C9-C14 carboxylic acid and of a C1-C4 alcohol, (d) at least one (C4-C26) dialkyl ether. The present invention relates more particularly to aqueous vaporizable compositions in particular in spray form and also to the pressurization devices containing them.

Abstract: Peptides able to inhibit the muscarinic receptor M3 activity and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions mediated by the muscarinic receptor M3 activity, such as excessive perspiration, inflammation, sebum production, and cell adhesion, motility, growth, differentiation and proliferation.

Abstract: Zinc oxide particles are prepared as a dry powder through a vapor phase formed by a plasma process, or by introducing defects into stoichiometric zinc oxide particles in a liquid carrier through mechanical stress. The zinc oxide has an O:Zn ratio of at least 0.99, an average particle size of 10 to 300 nm, and a sufficient concentration of oxygen vacancies and zinc vacancies to give a dispersion of the particles in C12-C15 alkyl benzoate an orange to tan color corresponding to a ?E value of at least 15 in a Dispersion Color Test. The particles contain no aggregates and have no detectable particles 500 nm or larger, on a number-weighted basis.

Abstract: The invention relates to a new zinc complex with gamma-L-glutamylhistamine with a metal/ligand ratio of 1/1. In particular, the invention relates to a compound of the formula The complex according to the invention helps to restore the barrier functions of the epithelial tissue and suppresses the aberrant activity of the immune cells. The invention also relates to the method of complex preparation and use of said zinc complex for the treatment of atopic dermatitis and other diseases associated with impaired barrier functions of epithelial tissue and the development of an aberrant inflammatory response. The invention also relates to the use of the prepared complex for inhibiting glutaminyl cyclase. This invention also concerns pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention.

Abstract: One composite composition of the present invention contains: a silicon fine particle; and a silicon suboxide (SiOX, wherein x is ½, 1, or 3/2) and/or a mixed composition of the silicon suboxide and silicon dioxide, at least partially covering the surface of the silicon fine particle.

Abstract: The present disclosure pertains to surfactants for use in the formulation of detergents, foaming agents, emulsifiers, and degreasers. Some aspects of the invention include formulations suitable for cleaning and/or condition fabrics including upholstery. Some formulations are suitable for in home or commercial dry cleaning. Some of the formulations may be suitable for cleaning hard surfaces including plastic surfaces.

Abstract: There is provided a method of producing silica capsules, the method comprising: adding a silica precursor to emulsified droplets in the presence of salt and alcohol to enhance silica growth around the emulsified droplets by an ion association effect, thereby forming silica capsules. Also provided are silica capsules producible by such a method.

Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted.

Abstract: A transdermal formulation which can be applied to the skin, body, face using a combination of glutathione, in the presence of a wide range of active components while increasing permeation of active antioxidant agents. A therapeutically effective amount creates in the patient (i) regulation of sleep, (ii) increased energy during awake periods, (iii) improved concentration during awake periods, (iv) reduction of facial wrinkles, and (v) reduction of joint and muscular pain with increases by at least 10 percent of the ability of skin to retain moisture and totally absorb the glutathione without requiring injection or oral supplementation of the glutathione.

Abstract: A deep-sea water concentrate skin application kit of deep-sea active concentrate and skincare formula is provided. The deep-sea water concentrate skin application kit has the following properties of micronizing the skincare formulas immediately, and decreasing the surface tension of the deep-sea active concentrate immediately; furthermore, the deep-sea active concentrate can become a driving force for the permeability of the micronized skincare formulas. Therefore, the deep-sea water concentrate skin application kit can be more easily absorbed into the skin (dermis). A manufacturing method of the deep-sea water concentrate skin application kit is also provided to improve skin appearance.

Abstract: A hair or skin treatment composition for improving health of hair or skin includes an ointment obtained by heating one or more of castor oil, animal fat, and vegetable oil with a mash comprising one or more of carrots, onions, coconut flesh, and watercress, for between one and eight hours to generate, after straining to remove solids, a preliminary oil mixture. The preliminary oil mixture is heated with one or more of citrus juice and nutmeg, for between one and eight hours, to generate, after straining to remove solids, an intermediate oil mixture. The intermediate oil mixture is heated with sulfur, petrolatum, and at least one agent configured for absorbing or blocking ultraviolet radiation to generate, upon cooling, the ointment, which can be applied to hair or skin of a user to effect a physical or aesthetic change thereto.

Abstract: The present invention relates to a method of obtaining a novel gelling agent. Said method comprises adding ethylcellulose, to a mixture of propyleneglycol laurate and propyleneglycol isostearate at a temperature of between 90° C. and 110° C. The method according to the invention provides a simpler, less energy consuming, cheaper and easier way of obtaining a substantially gelling agent which can be used for manufacturing an oleogel and/or a bigel, for cosmetic and/or pharmaceutical use.

Abstract: An improved a method of treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: Disclosed are stable microcapsule compositions each containing a microcapsule dispersed in an aqueous phase and a stabilizing agent. The microcapsule compositions are stable for at least 4 weeks when storing at 45° C., and the microcapsule composition is considered stable when (i) the composition has a viscosity of 3000 cP or less and (ii) 20% or less water by volume of the composition is separated from the composition. Also disclosed are consumer products having such a stable microcapsule composition.

Abstract: A method of improving skin health and condition comprising the application of select isohexides to the skin.

Abstract: The present invention is directed to methods for improving the therapeutic outcome of treatment with roflumilast. The therapeutic outcome is improved by consistent delivery and/or a longer plasma half-life of a topically administered roflumilast composition. The roflumilast composition preferably includes dicetyl phosphate, ceteth-10 phosphate, diethylene glycol I monoethyl ether, and/or hexylene glycol.

Abstract: Disclosed is a leave-on water-in-oil cosmetic emulsion that includes an aqueous phase comprising water and a hydrophilic thickening agent consisting of polyvinylpyrrolidone, the aqueous phase being free of other hydrophilic thickening agents, a mattifying filler including a silicone elastomer, an organic ultraviolet filter consisting of octyl salicylate, at least one silicone oil, and at least one silicone emulsifier.

Abstract: Disclosed is a method for providing customized skin color matching sunscreen for a user. The method includes adding one or more basic sunscreen compounds, wherein the one or more sunscreen compounds includes at least one sun blocking active agent, adding a pigmented solution to the one or more basic sunscreen compounds, wherein the pigmented solution includes one or more pigments, determining a first amount of the one or more basic sunscreen compounds and a second amount of the pigmented solution for mixing, wherein the determining the first amount and the second amount is performed based on at least a skin tone of the user, and mechanically mixing the first amount and the second amount.

Abstract: The present invention relates to topical compositions comprising at least one liquid UV-filter and a nano-sized 1,4-di(benzoxazol-2?-yl)benzene.

Abstract: Novel isohexides and pharmaceutical compositions containing the same as well as methods of using the same in the treatment of psoriasis.