Abstract: Peptides able to inhibit the muscarinic receptor M3 activity and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions mediated by the muscarinic receptor M3 activity, such as excessive perspiration, inflammation, sebum production, and cell adhesion, motility, growth, differentiation and proliferation.

Abstract: The present invention relates to a fluid composition intended for the protection of keratin materials against ultraviolet radiation, characterized in that it comprises at least: (a) a photoprotective system capable of screening out UV radiation, (b) at least one diester of a C2-C8 carboxylic acid and of a C1-C4 alcohol, (c) at least one diester of a C9-C14 carboxylic acid and of a C1-C4 alcohol, (d) at least one (C4-C26) dialkyl ether. The present invention relates more particularly to aqueous vaporizable compositions in particular in spray form and also to the pressurization devices containing them.

Abstract: Zinc oxide particles are prepared as a dry powder through a vapor phase formed by a plasma process, or by introducing defects into stoichiometric zinc oxide particles in a liquid carrier through mechanical stress. The zinc oxide has an O:Zn ratio of at least 0.99, an average particle size of 10 to 300 nm, and a sufficient concentration of oxygen vacancies and zinc vacancies to give a dispersion of the particles in C12-C15 alkyl benzoate an orange to tan color corresponding to a ?E value of at least 15 in a Dispersion Color Test. The particles contain no aggregates and have no detectable particles 500 nm or larger, on a number-weighted basis.

Abstract: The invention relates to a new zinc complex with gamma-L-glutamylhistamine with a metal/ligand ratio of 1/1. In particular, the invention relates to a compound of the formula The complex according to the invention helps to restore the barrier functions of the epithelial tissue and suppresses the aberrant activity of the immune cells. The invention also relates to the method of complex preparation and use of said zinc complex for the treatment of atopic dermatitis and other diseases associated with impaired barrier functions of epithelial tissue and the development of an aberrant inflammatory response. The invention also relates to the use of the prepared complex for inhibiting glutaminyl cyclase. This invention also concerns pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention.

Abstract: One composite composition of the present invention contains: a silicon fine particle; and a silicon suboxide (SiOX, wherein x is ½, 1, or 3/2) and/or a mixed composition of the silicon suboxide and silicon dioxide, at least partially covering the surface of the silicon fine particle.

Abstract: The present disclosure pertains to surfactants for use in the formulation of detergents, foaming agents, emulsifiers, and degreasers. Some aspects of the invention include formulations suitable for cleaning and/or condition fabrics including upholstery. Some formulations are suitable for in home or commercial dry cleaning. Some of the formulations may be suitable for cleaning hard surfaces including plastic surfaces.

Abstract: There is provided a method of producing silica capsules, the method comprising: adding a silica precursor to emulsified droplets in the presence of salt and alcohol to enhance silica growth around the emulsified droplets by an ion association effect, thereby forming silica capsules. Also provided are silica capsules producible by such a method.

Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted.

Abstract: A transdermal formulation which can be applied to the skin, body, face using a combination of glutathione, in the presence of a wide range of active components while increasing permeation of active antioxidant agents. A therapeutically effective amount creates in the patient (i) regulation of sleep, (ii) increased energy during awake periods, (iii) improved concentration during awake periods, (iv) reduction of facial wrinkles, and (v) reduction of joint and muscular pain with increases by at least 10 percent of the ability of skin to retain moisture and totally absorb the glutathione without requiring injection or oral supplementation of the glutathione.

Abstract: A deep-sea water concentrate skin application kit of deep-sea active concentrate and skincare formula is provided. The deep-sea water concentrate skin application kit has the following properties of micronizing the skincare formulas immediately, and decreasing the surface tension of the deep-sea active concentrate immediately; furthermore, the deep-sea active concentrate can become a driving force for the permeability of the micronized skincare formulas. Therefore, the deep-sea water concentrate skin application kit can be more easily absorbed into the skin (dermis). A manufacturing method of the deep-sea water concentrate skin application kit is also provided to improve skin appearance.

Abstract: A hair or skin treatment composition for improving health of hair or skin includes an ointment obtained by heating one or more of castor oil, animal fat, and vegetable oil with a mash comprising one or more of carrots, onions, coconut flesh, and watercress, for between one and eight hours to generate, after straining to remove solids, a preliminary oil mixture. The preliminary oil mixture is heated with one or more of citrus juice and nutmeg, for between one and eight hours, to generate, after straining to remove solids, an intermediate oil mixture. The intermediate oil mixture is heated with sulfur, petrolatum, and at least one agent configured for absorbing or blocking ultraviolet radiation to generate, upon cooling, the ointment, which can be applied to hair or skin of a user to effect a physical or aesthetic change thereto.

Abstract: An improved a method of treating a patient having a disorder responsive to PDE-4 inhibition by administering roflumilast. The improvement involves administering the roflumilast topically in a composition having a roflumilast release profile that produces in the patient a flattened plasma concentration time curve and a reduced Cmax relative to oral administration of a PDE4-inhibiting amount of roflumilast. Such disorders include inflammatory disorders such as inflammatory dermatoses, including psoriasis, atopic dermatitis and seborrheic dermatitis. Such disorders also include inflammatory diseases in a variety of organs, especially the lungs (asthma, COPD). Because of reduced side effects with topical administration due to the improved pharmacokinetics (PK) characteristics, it may be possible to provide higher systemic exposures (AUCs) with topical administration, resulting in greater therapeutic efficacy than with the oral route of administration.

Abstract: The present invention relates to a method of obtaining a novel gelling agent. Said method comprises adding ethylcellulose, to a mixture of propyleneglycol laurate and propyleneglycol isostearate at a temperature of between 90° C. and 110° C. The method according to the invention provides a simpler, less energy consuming, cheaper and easier way of obtaining a substantially gelling agent which can be used for manufacturing an oleogel and/or a bigel, for cosmetic and/or pharmaceutical use.

Abstract: A method of improving skin health and condition comprising the application of select isohexides to the skin.

Abstract: Disclosed are stable microcapsule compositions each containing a microcapsule dispersed in an aqueous phase and a stabilizing agent. The microcapsule compositions are stable for at least 4 weeks when storing at 45° C., and the microcapsule composition is considered stable when (i) the composition has a viscosity of 3000 cP or less and (ii) 20% or less water by volume of the composition is separated from the composition. Also disclosed are consumer products having such a stable microcapsule composition.

Abstract: The present invention is directed to methods for improving the therapeutic outcome of treatment with roflumilast. The therapeutic outcome is improved by consistent delivery and/or a longer plasma half-life of a topically administered roflumilast composition. The roflumilast composition preferably includes dicetyl phosphate, ceteth-10 phosphate, diethylene glycol I monoethyl ether, and/or hexylene glycol.

Abstract: Disclosed is a leave-on water-in-oil cosmetic emulsion that includes an aqueous phase comprising water and a hydrophilic thickening agent consisting of polyvinylpyrrolidone, the aqueous phase being free of other hydrophilic thickening agents, a mattifying filler including a silicone elastomer, an organic ultraviolet filter consisting of octyl salicylate, at least one silicone oil, and at least one silicone emulsifier.

Abstract: The present invention relates to topical compositions comprising at least one liquid UV-filter and a nano-sized 1,4-di(benzoxazol-2?-yl)benzene.

Abstract: Disclosed is a method for providing customized skin color matching sunscreen for a user. The method includes adding one or more basic sunscreen compounds, wherein the one or more sunscreen compounds includes at least one sun blocking active agent, adding a pigmented solution to the one or more basic sunscreen compounds, wherein the pigmented solution includes one or more pigments, determining a first amount of the one or more basic sunscreen compounds and a second amount of the pigmented solution for mixing, wherein the determining the first amount and the second amount is performed based on at least a skin tone of the user, and mechanically mixing the first amount and the second amount.

Abstract: A cosmetic active principle including a hydrolysate of Pichia minuta comprising at least peptides. Additionally, the use of the cosmetic active principle including a hydrolysate of Pichia minuta comprising at least peptides for controlling hair loss and stimulating regrowth. Also, compositions containing same and a cosmetic hair treatment method.

Abstract: This disclosure relates to a composition for facilitating transdermal delivery of vitamin D while preventing UV light from reaching user skin includes a concentration of cholecalciferol within a range of about 10 IU/g to about 40,000 IU/g. The composition includes one or more metal oxides such as zinc oxide and/or one or more titanium oxides which function to prevent (or at least limit) UV light from reaching user skin. The metal oxide(s) are provided at a concentration within a range of about 10% to about 50% by weight of the total composition.

Abstract: The presently disclosed subject-matter provides specific compositions, conjugates, device, kits and systems for depleting fibrinolytic agents from biological fluids. The presently disclosed subject-matter further relates to the resulting biological fluid products that are devoid in fibrinolytic activity, therapeutic methods and uses thereof. The conjugates comprise a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof being at least one of 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), epsilon-amino caproic acid, lysine, cyclohexanecarboxylic acid and 4-methyl-cyclohexanecarboxylic acid. A plurality of different conjugates (e.g. differing in particle size or type of linker) can be used.

Abstract: The non-therapeutic, cosmetic, oral use of a composition as an active ingredient for whitening and/or lightening the skin and/or depigmenting the skin, in particular for reducing the size of brown spots, including at least cystine and glutathione in a cystine/glutathione ratio ranging from 1.5 to 4, the composition advantageously further comprising glycine and/or glutamine Preferably, the composition also includes at least one component selected from the group formed by zinc or one of its salts, copper or one of its salts, selenium or one of its salts, vitamins B, in particular B3, B5, B6 and/or B8, vitamin E, melon juice extracts, horsetail extracts and mixtures of these components.

Abstract: A system for monitoring ultraviolet (UV) exposure of a wearer. The system comprises a wearable device operable to sense UV radiation levels to which the wearer is exposed, and to transmit UV radiation information. The system further comprises an external computing device in remote communication with the wearable device, operable to receive the UV radiation information from the wearable device and configured to determine the wearer's real-time UV index value and the wearer's daily cumulative percentage of minimal erythema dose based upon the UV radiation information.

Abstract: In some aspects, the techniques described herein relate to a topical dermatologic acne treatment method using a cream. The treatment method uses two steps, first providing a bactericidal component and second providing a skin revitalizing complex. The bactericidal component clears the acne causing bacteria. The subsequent skin revitalizing complex revitalizes and conditions the skin and aids in return of natural skin flora and microbiome to prevent subsequent outbreaks. The skin revitalizing complex can include a variety of components such as: niacinamide, retinol, bakuchiol, green coffee bean extract, green tea extract, epilobium fleischeri extract, citric acid, dimethicone, and pentaerythrityl tetracaprylate. The skin revitalizing complex restores natural elasticity and oil production of the skin, decrease sebum production, and provide necessary conditioning of the skin to provide for the natural skin flora and microbiome to repopulate and flourish on a surface of the skin.

Abstract: There is provided a petrolatum substitute. The petrolatum substitute preparation comprises 1-20 wt % of at least one oil thickening agent, 7-40 wt % of at least one structuring agent, 0.5-10 wt % of at least one phytosterol or ester thereof, and 30-92 wt % of at least one emollient, wherein the preparation has a melting point of 35° C. or more. The petrolatum substitute preparation can be used in essentially all applications where petrolatum is used today. The substitute can be made renewable and the use of over-exploited natural products is minimized. The preparation is less irritant and has excellent moisture barrier properties when applied to human skin. Further it is less energy consuming to manufacture.

Abstract: The present disclosure provides compounds and compositions which may be used to augment, supplement and/or replace the products of certain UV sensitive/dependent processes. In particular, the disclosure provides sunscreen compositions which avoid problems associated with prior art sunscreen compositions which inhibit the natural progression of certain in vivo sunlight/UV dependent processes including processes which result in Nitric Oxide/Vitamin D production in the skin.

Abstract: A personal skincare product that provides cleansing, antiseptic, antibacterial, soothing, moisturizing, protective, and healing benefits to irritated skin and wounds for all ages, particularly for consumers with sensitive and fragile skin like children and the elderly. The personal skincare product comprises a topical antiseptic comprising water, benzalkonium chloride, phenoxyethanol, aloe, liquid coconut, propylene glycol, collagen, polyethylene glycol, sodium benzoate, petrolatum, lanolin, mineral oil, cod liver oil, paraffin, sodium, olive oil, cottonseed oil, vitamin E, and a non-ionic copolymer such as Poloxamer 188 or a combination therefrom.

Abstract: Disclosed are an oil-dispersed composition and a cosmetic for lip care manufactured using the same. The oil-dispersed composition includes a water-soluble raw material, an ester oil including a glyceryl group and/or an isostearyl group, a paste, and a thickener, wherein the paste and thickener are included in an amount of greater than or equal to about 30 wt % based on the total amount of the oil-dispersed composition.

Abstract: A production procedure for procedure for Alquernat Coneb, a poultry feed (broiler breeders and turkeys) based on alliin, carvacrol, cimenol and inulin from vegetable extracts, and its use in the prevention of parasitic infestations.

Abstract: The present invention relates to topical compositions comprising at least one polar oil and a micronized 1,4-di(benzoxazol-2?-yl)benzene having a mean particle size of at most 300 nm as well as to the use of such a micronized 1,4-di(benzoxazol-2?-yl)benzene to reduce the transfer of such oils to surfaces.

Abstract: This invention refers to pharmaceutical compositions containing synergistic combinations of pentacyclic triterpenoids as active principles and denotes that some specific combinations between these types of drugs exhibit effects for the prevention or inhibition of viral infections. The compositions are found in specific quantities and proportions that enhance the pharmacological properties of the compounds, improving their bioavailability and pharmacokinetic properties, while reducing their toxicological and irritability effects, especially in the respiratory tract and the lungs.

Abstract: The subject of the present invention is a process for treating keratin fibers using a) at least one silicone comprising at least one carboxylic acid anhydride group, b) at least one amino silicone, and c) at least one coloring agent chosen from pigments, direct dyes and mixtures thereof, the compounds a), b) and c) being applied together or separately, in one or more compositions.

Abstract: A composition, especially a cosmetic composition, in particular for making up and/or caring for keratin materials, including at least one aqueous phase gelled with at least one hydrophilic gelling agent; and at least one oily phase gelled with at least one lipophilic gelling agent chosen from organopolysiloxane elastomers; said phases forming therein a macroscopically homogeneous mixture. The composition also includes a dispersion of solid aggregates, said aggregates being formed from 10% to 80% by weight of wax(es), relative to their total weight. Also disclosed is a process for preparing such a composition.

Abstract: The present invention relates generally to methods and compositions useful to cleanse, exfoliate, smooth, moisturize, hydrate, and/or improve the appearance and/or condition of skin and/or hair using a composition including shea butter, PEG-50 shea butter, and/or hydrated silica.

Abstract: Methods of producing a Hydrophilic Homeopathic Aqueous Substance Active (HASA)-gel matrix, include the steps of: (a) combining a homeopathic compound and an uninhibited aqueous composition to produce a HASA; (b) combining the HASA with at least one hydrophilic gelling agent; and (c) thereafter, forming the hydrophilic HASA-gel matrix by use of at least one of a thickening agent, a crosslinking agent, or a polymerization agent.

Abstract: Compositions are provided for removing nail polish that include a co-mixture of monoalcohol, glycerin, and solvent consisting of C2-C3 monoalcohol, glycerin, and a solvent selected from acetone, a C2-C4 alkyl acetate, and combinations thereof. The composition for includes a co-mixture of monoalcohol, glycerin, and solvent that consists of C2-C3 monoalcohol; glycerin; and less than 55% by weight of solvent selected from acetone, a C2-C4 alkyl acetate, and combinations thereof. The glycerin and the C2-C3 monoalcohol are present in a glycerin to C2-C3 monoalcohol weight ratio of greater than about 0.6. If the solvent includes C2-C4 alkyl acetate then the concentration of C2-C4 alkyl acetate is less than 30% by weight. The composition further includes polyacrylamide and water. The concentration by weight of water in the composition is less than the concentration by weight of glycerin. Methods are also provided.

Abstract: Disclosed is a self-invertible inverse latex including, as an inverting agent, surfactant species of the polyglycerol ester family, the use thereof as a thickening and/or emulsifying and/or stabilising agent for a detergent or cleaning formulation for industrial or household use, and aqueous liquid detergent compositions including same, for household or industrial use.

Abstract: A sunscreen comprises red iron oxide and a mineral sunscreen blend, that is universal with all skin colors and prevents ashy skin.

Abstract: A liquid cosmetic composition which provides easily a clear and brilliant coating film without causing flaky pigments to be overlapped on each other when the liquid cosmetic composition containing a small amount of brilliant flaky pigments is filled in an applicator having a coating part composed of a brush to be coated on a surface such as a skin. The liquid cosmetic composition of the present invention is characterized in containing at least 0.01 to 10 mass % of a flaky pigment coated on a surface with a compound selected from the following A group, 0.05 to 5 mass % of layered clay mineral particles, 1 to 20 mass % of an acrylic copolymer in terms of a solid content and water and being filled in an applicator provided with a coating part having a brush: A group: cellulose, hemicellulose, lignin, chitin, chitosan.

Abstract: Personal care compositions and methods for preparing the same are disclosed. The personal care composition may include an emulsifying system, one or more emollients, and one or more humectants. The method for preparing the personal care composition may include contacting the emulsifying system, the one or more emollients, and the one or more humectants with one another.

Abstract: Disclosed is a method of improving a condition or appearance of skin. The method can include applying to skin an effective amount of a topical skin composition comprising tetrahexyldecyl ascorbate, Phyllanthus emblica fruit extract, and tocopherol or tocopherol acetate.

Abstract: Disclosed in certain embodiments are skincare formulations and treatment methods having hyaluronic acid, or its associated salts, and one or more of ascorbic acid, glycolic acid or lactic acid. In certain embodiments, the formulations and treatments are applied to the skin during and/or before and/or after dermatological procedures that affect the skin's barrier for alleviating patient discomfort and enabling rapid healing of irritated and damaged skin.

Abstract: The present invention is directed to a personal care composition comprising from about 12% to about 25% of one or more surfactants; from about 0.01% to 10% of one or more soluble scalp health active; from about 0.1% to about 4% of a thickening polymer wherein the thickening polymer is selected from the group consisting of homopolymers based on acrylic acid, methacrylic acid or other related derivatives, alkali swellable and hydrophobically-modified alkali swellable acrylic copolymers or methacrylate copolymers, soluble crosslinked acrylic polymers, associative polymeric thickeners and mixtures thereof; from 0.01% to 0.8% of a cationic polymer; wherein the personal care composition has a pH of about 4.5 to about 6 and wherein the personal care composition has a Haze value less than or equal to 25.

Abstract: A cosmetic composition with enhanced water resistance, color intensity and color retention after exposure to water is disclosed herein. The composition comprises a water dispersible film former component, a skin adhesion promoter component, a color enhancer component, and one or more colorants. The synergy of the components contributes to the improved attributes of the composition.

Abstract: A hair coloring composition that includes about 5 to 25 wt. % of a first monosaccharide having 2 to 4 carbon atoms, up to about 10 wt. % of a second monosaccharide having 2 to 4 carbon atoms, about 0.1 to 5 wt. % of a surfactant, and about 0.1 to 5 wt. % of a delivery agent, each based on a total weight of the hair coloring composition. A method for coloring hair, that involves applying the hair coloring composition onto the hair, and optionally applying heat to the hair at a dyeing temperature of 30 to 205° C.

Abstract: The invention relates to the use of an agent and a composition, respectively, comprising the following active ingredients: a) an aromatase inhibitor and/or a 5-?-reductase inhibitor, b) an antioxidant, and c) hyaluronic acid for cosmetic purposes.

Abstract: The use of long-chain alkenones to impart desired characteristics in personal care compositions for topical applications is described. The preparation of mixtures long-chain alkenones and synthetic derivatives thereof is presented. Examples of compositions include abrasive soaps, with alkenones serving as natural exfoliating agents. Alkenones and their derivatives can serve as emollients, occlusive agents, encapsulating agents, stabilizing agents, binding agents, thickening agents, surfactants, and antimicrobials.

Abstract: The present invention relates to a composition, preferably a cosmetic composition, and more preferably a skin cosmetic composition, comprising: (a) at least one particle, comprising at least one cationic polymer and at least one anionic polymer, at least one cationic polymer and at least one amphoteric polymer, at least one anionic polymer and at least one amphoteric polymer, or at least one amphoteric polymer, and at least one non-polymeric acid having two or more pKa values or salt(s) thereof or at least one non-polymeric base having two or more pKb values or salt(s) thereof; (b) at least one oil; and (c) water. The composition according to the present invention is stable, and can have a variety of cosmetic functions. For example, the composition according to the present invention can prepare a film which can have cosmetic effects such as moisturizing due to the oil(s).

Abstract: Novel isohexides and pharmaceutical compositions containing the same as well as methods of using the same in the treatment of psoriasis.