Abstract: The present invention provides topical formulations having an autophagy stimulating and/or heme oxygenase and activating/triggering effect on human skin for cosmetic and pharmaceutical use. Furthermore, the present invention provides topical formulations that trigger production of VEGF-C, reduce melanin synthesis and boost energy and cell function. Moreover, the present invention provides a new process for producing a herbal composition comprising a mixture of components of Bellis perennis L. and optionally Hieracium pilosella by aqueous extraction and the herbal composition comprising a mixture of components produced by the process of the present invention. The pharmaceutical formulations according to the present invention may be used for the treatment or prevention of dark circles under the eye and/or puffy eyes. The herbal composition according to the present invention may also be used in a cosmetic formulation for the cosmetic treatment or prevention of dark circles under the eye and/or puffy eyes.

Abstract: The disclosure relates to thermal control of compositions for altering the color of hair, in particular to hair bleaching compositions comprising thermal control agents, hair color-altering compositions comprising the hair bleaching compositions and/or thermal control agents, methods for preparing and using the hair color-altering compositions, and kits comprising the hair bleaching compositions and/or thermal control agents.

Abstract: Methods and compositions for improving the appearance of skin are provided. The methods and compositions are especially suited for inhibiting activation of PAR2 in skin by utilizing a synergistic combination of a water lily extract and vitamin B3 compound. The method involves treating hyperpigmented skin by applying a skin care composition containing an effective amount of a combination of water lily extract and vitamin B3 compound to a target portion of skin over the course of a treatment period.

Abstract: Compositions include a hydrophobic continuous phase having a powdery oxidizing agent (e.g. silver oxynitrate) and a disperse hydrophilic phase comprising at least one hydrophilic substance (e.g. fumed silica) that maintain antimicrobial/anti-biofilm activities; and methods for preparing and using same.

Abstract: A liquid fragrance composition contains (i) 3 wt % to 40 wt % of a fragrance, (ii) 0.5 wt % to 5 wt % of glyceryl ricinoleate, and (iii) 60 wt % to 95 wt % of water. Also disclosed are consumer products containing such a liquid fragrance composition.

Abstract: The present invention belongs to the area of cosmetics that comprise at least an active agent which cause stinging, pricking, tingling and burning sensation on skin as a side effect. The invention in particular relates to a spray dried composition and the method as well as the use of the spray dried composition comprising said stinging, pricking, tingling and burning active agents to reduce and/or inhibit stinging, pricking, tingling and burning sensation on skin.

Abstract: The present invention relates to sunscreen compositions. More specifically, the present invention relates to sunscreen compositions that, when applied to the skin, prevent sun damage while allowing the passage of sufficient UVB in the range of 290 nm-298 nm to produce vitamin D, while also inhibiting melanogenesis.

Abstract: The disclosure provides a method of isolating one or more compounds present in fruit seed extracts that have anti-ty-rosinase or whitening activity, compositions having one or more fruit seed extracts that have anti-tyrosinase or whitening (lightening) activity.

Abstract: The present invention relates to a process for treating keratin fibers such as the hair using a packaging article comprising i) an envelope defining at least one cavity, the envelope comprising water-soluble and/or liposoluble fibres, preferably water-soluble fibres; ii) at least one anhydrous oxidizing composition, preferably in paste or powder form, comprising at least one anhydrous chemical oxidizing agent, preferably in paste or powder form; it being understood that the oxidizing composition is in one of the cavities defined by the envelope i).

Abstract: Disclosed is to provide a composition for skin-whitening or preventing or improving skin wrinkles, comprising a green tea extract which has modified amounts of ingredients. More specifically, the extract and composition according to one aspect of the present disclosure are derived from natural plants that cause less irritation to the skin and are eco-friendly, thus they are safe, and thereby the extract and composition can exhibit excellent effects of effectively inhibiting melanin production and tyrosinase activity and preventing or improving skin whitening, and can exhibit excellent effects of effectively inhibiting the expression of MMP-1 and preventing or improving skin wrinkles.

Abstract: A method for treating skin of a person is disclosed. The method can include topically applying to the skin of the person a composition comprising an effective amount of an aqueous, alcoholic, or aqueous-alcoholic extract from Ficus retusa ssp. nitida, wherein the composition reduces tyrosinase activity or melanin production in the skin.

Abstract: A plant derived active ingredient and a cosmetic and a drug composition including the plant derived ingredient including: an extract from at least one plant of the gender Olea, an extract from at least one plant of the gender Tilia and/or an extract from at least one plant of the gender Cydonia.

Abstract: The present invention relates to cosmetic and pharmaceutical compositions each containing a composite extract. More specifically, the present invention provides cosmetic and pharmaceutical compositions, each of which contains, as an active ingredient, a composite extract of an aloe extract and an upland rice extract, leading to excellent moisturizing, anti-inflammatory, and atopy alleviating effects, and thus can be favorably used for prevention, alleviation, and treatment of a skin disease.

Abstract: The disclosure relates to systems and methods for improving the manufacturing of silk solutions and powders containing silk fibroin obtained from silkworm cocoons. The methods include use of a reactor vessel to degum, rinse, and dissolve the silk fibroin protein from silk inputs to obtain a food grade silk powder. The reactor vessel may include a combination of inputs and outputs for introducing and removing different components used or generated during the process. The systems may include any combination of heat exchangers, holding tanks, filtration modules, and post-treatment equipment as necessary to obtain the silk powder. The solutions and powders can be used to improve the post-harvest preservation of perishables and to improve the performance of packaging, including biodegradable packaging.

Abstract: Some embodiments disclosed herein pertain to compositions for extinguishing or suppressing fires, systems for using the same, methods of making compositions for extinguishing or suppressing fires, and/or methods of using the same. In some embodiments, the compositions disclosed herein are suitable for use on Class D fires (e.g., suppressing or extinguishing the fires). In some embodiments, the compositions disclosed herein comprise a botanical material. In some embodiments, the compositions lack sugar alcohols and/or halogenated compounds.

Abstract: A method of reducing the appearance of hyperpigmented skin is disclosed. The method can include topically applying to hyperpigmented skin a composition comprising an aqueous and/or glycerin extract of Rhododendron ferrugineum leaf to reduce melanocyte pigmentation in the skin.

Abstract: The present disclosure relates to transparent ready-to-use hair bleaching compositions and compositions useful for preparing the transparent ready-to-use hair bleaching compositions. The transparent ready-to-use bleaching compositions typically include: (i) one or more oxidizing agents selected from the group consisting of persulfates, perborates, percarbonates, a salt thereof, and a mixture thereof; (ii) one or more non-acrylic thickening polymers; (iii) one or more acrylic polymers; (iv) hydrogen peroxide; (v) one or more polyurethane polyethers; and (vi) water. Kits and methods for bleaching hair also disclosed.

Abstract: The present invention relates to a process for stripping keratin fibres, and in particular human keratin fibres such as the hair, dyed with oxidation dyes and/or direct dyes, using a composition obtained by extemporaneous mixing of an anhydrous or aqueous composition (A) comprising at least one suitably selected sulfinic acid derivative and an aqueous composition (B) with a pH of less than (5), comprising at least one organic acid other than the compounds of formula (I), with a pKa of less than or equal to (4) when the composition (A) is aqueous, the pH of the mixture of the two compositions (A) and (B) being less than or equal to (5). The invention also relates to a composition for stripping the artificial colour from keratin fibres, comprising at least one suitably selected sulfinic acid derivative and at least one thickener chosen from anionic polymers and nonionic polymers.

Abstract: Disclosed herein are methods for improving digestive health by providing a consumable composition. Some embodiments provided include, for example, administering a compound of Formula (I) or compound of Formula (II). Some embodiments provide the composition is formulated as a dietary supplement, food ingredient or additive, a medical food, nutraceutical or pharmaceutical composition.

Abstract: The present invention relates to a method for the cosmetic treatment of keratin materials, comprising the application of a composition to the keratin materials, such as the skin, said composition comprising a compound (I), wherein R1, R2 and R3 are as defined in the description and S* is a mono or polysaccharide.

Abstract: Compositions are provided that contain biologically active components of amniotic fluid including growth factors and other proteins, carbohydrates, lipids, and metabolites. The compositions containing biologically active components of amniotic fluid can be useful for a range of therapeutic treatments including joint and soft tissue repair, regulation of skin condition, and for use in organ preservation, such as for use in organ transplant procedures. Advantages of the compositions include that they can be reproducibly produced, without the inherent variability of amniotic fluid from individual donors, and that they are free of fetal waste.

Abstract: A pulp and skin extract from dried, seed-free Myrciaria dubia fruit. The Myrciaria dubia fruit has a maturity of at least 70%, a soluble solids/acidity ratio between 2.5 and 3, and it is rich in organic acids. The extract is obtained by solid-liquid extraction in a hydro-polyalcohol solvent selected from a hydro-glycerol and/or hydro-gylcolic solvent under agitation or with ultrasound. The extract is an active agent in cosmetic compositions, which reduce the signs of skin fatigue.

Abstract: The disclosure relates to a composition for dyeing keratin fibers, in particular human keratin fibers such as hair, comprising one or more oxidation dyes, one or more scleroglucan gums in a total weight content greater than or equal to 0.5% relative to the total weight of the composition, one or more alkaline agents selected from amino acids, the amino acid(s) being present in a total weight content greater than or equal to 1% relative to the weight of the composition, and preferably one or more additional alkaline agents, preferably selected among the mineral alkaline agents and/or alcanolamines. A method for dyeing keratin fibers using said composition and a multi-compartment device suitable for implementing said composition are also disclosed.

Abstract: Disclosed are compositions and methods for their use that can be used individually or in combination. The compositions have the ability to treat a wide range of skin and skin conditions, and particularly men's skin.

Abstract: The present application relates to the treatment of autism and autism spectrum disorders using biotin compositions.

Abstract: The present invention relates to compositions of therapeutic yeast extracts for treatment of inflammatory conditions, methods of production of those extracts and methods of treating inflammatory skin/tissue afflictions.

Abstract: A composition to improve hyperpigmentation is disclosed. The composition has one or more active ingredients such as tranexamic acid, niacinamide, arbutin, and Vitamin C. The composition has water, caprylic/capric triglyceride, C12-15 Alkyl Benzoate, Isononyl Isononanoate, Silica, Glyceryl Stearate and PEG-100 Stearate, Cetearyl Alcohol and Ceteareth-20, Xylitylglucoside and Anhydroxylitol and Xylitol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Phenoxyethanol and Ethylhexylglycerin, Citric Acid, Titanium Dioxide, Citrus oil, sh-Polypeptide-22, and sh-Oligopeptide-1. The composition is a non-HQ formulation that provides equal or greater efficacy with a reduced adverse reaction profile to improve skin hyperpigmentation, such as melasma, post-inflammatory hyperpigmentation, and solar lentigines. The composition reduces skin damage and provides toning to the skin.

Abstract: In one embodiment, the present invention provides a personal care composition, comprising: (i) a compound of Formula (1) at a concentration from 0.0001 wt % to 20 wt % of the composition; wherein R is selected from the group consisting of C15-C23 conjugated dienes, C15-C23 hydroxylated mono unsaturated alkenes, and C15-C23 hydroxylated alkanes; wherein R1 is selected from the group consisting of H, C1-C4 alkyl, —CH2OH, —CH2(CH3)—OH, —[CH2]4—NH2, —CH2—CO2H, —[CH2]2—CO2H, wherein R3 is —CO2H; —CH2CO2H; —CH2CH2CO2H; and (ii) a cosmetically acceptable carrier.

Abstract: A hangover alleviating composition comprising a conjugate of sesamol and a peptide as an active ingredient. Specifically, the conjugate of sesamol and a peptide according to the present invention significantly increases the activity of alcohol dehydrogenase (ADH) or aldehyde dehydrogenase (ALDH) involved in the alcohol metabolising process, quickly breaks down the concentration of alcohol in the body, and improves alcohol-induced motor impairment, thus having the advantage of being able to be usefully used as an active ingredient in a hangover alleviating composition.

Abstract: The present application relates to a compositions and methods comprising or expressing a MOMO30 protein derived from Momordica balsamina. The MOMO30 protein is about 30 kDa in size, binds coronavirus S protein, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to coronavirus spike (S) protein, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by a coronavirus or alleviating symptoms in coronavirus infected patients and comprises the amino acid sequence of SEQ ID NO: 1. The MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating viral infections by coronaviruses and others.

Abstract: The invention disclosed herein relates to synergistic nutritional compositions for enhancing cellular ATP efficiency. Particularly, the invention relates to a synergistic, efficient, nutritional composition for promoting cellular ATP production comprising a therapeutically active exogenous combination of a stabilized oxaloacetate and a biotin-manganese complex along with pharmaceutically acceptable excipients; wherein the stabilized oxaloacetate and the biotin-manganese or salts thereof are present in a weight ratio ranging from 1:0.01 to 1:0.2. Further, the present synergistic nutritional composition is useful for treating ATP deficiency disorders, age-related metabolic disorders, neurodegenerative diseases, cardiovascular diseases, bone related disorders, central nervous system diseases, cognitive disorders and like thereof.

Abstract: Multi-component package unit (kit-of-parts), ready-to-use agent, and methods for reductive decolorizing of dyed keratinous fibers are provided herein. In an embodiment, a multi-component package unit includes, separately packaged, a first container (A), a second container (B), and a third container (C). The first container (A) includes a cosmetic agent (a) that includes (a1) one or multiple reducing agents chosen from the group of formamidine sulfinic acid, sodium dithionite, zinc dithionite, potassium dithionite, hydroxymethanesulfinic acid, aminomethanesulfinic acid, cysteine, thiolactic acid, sulphanylacetic acid (thioglycolic acid) and/or ascorbic acid. The second container (B) includes a cosmetic agent (b) that includes one or multiple oxidizing agents. The third container (C) includes a cosmetic agent (c) that includes (c1) one or multiple alkalizing agents. The weight ratio of the total amount of all reducing agents (a1) to the total amount of all oxidants (b1) has a value from about 50.0 to about 4.0.

Abstract: The present invention relates to cosmetic anti-blemish compositions in gel form that are particularly useful in the lightening of shadows and in the reduction of bags under the eyes.

Abstract: The present disclosure concerns a cosmetic product for modifying the natural colour of keratinous fibres, in particular human hair, comprising at least one packaging (VP) and a cosmetic composition (KM) contained in this packaging (VP). The packaging is made of a multilayer film (F) containing at least two polymer layers (P1) and (P2) and at least one barrier layer (BS). The cosmetic composition comprises at least one oxidizing agent, at least one C8-C30-alcohol, at least one specific anionic surfactant, at least one non-ionic surfactant and at least one acrylic acid-based thickener. The use of the packaging (VP) in combination with the cosmetic composition (KM) surprisingly does not lead to an inflation of the packaging or an excessive loss of water of the agent (KM) during storage.

Abstract: A hair cosmetic that has a better color when performing hair dye includes a hair cosmetic composition containing an alkali agent, an amino acid, a higher alcohol having 12 to 22 carbon atoms, a surfactant, and a thickener. The alkaline agent may be at least one of aqueous ammonia, ammonium carbonate, sodium carbonate, ethanolamines, ammonium bicarbonate, and arginine.

Abstract: A hair coloring method that has a better property of keeping color quality, hardly damages hair, reduces skin damage and is free of paraphenylenediamine when performing hair dye comprises a step of applying a mixture of the following (A) and (B) in a predetermined ratio: (A) a hair coloring agent comprising at least a basic dye, an HC dye, a second amino acid, a first cationic surfactant, a thickener, an oil agent, a first pH adjuster and a wetting agent, wherein the hair coloring agent has a pH of 6.8 or more, and (B) a hair cosmetic comprising at least an alkaline agent, a first amino acid, a higher alcohol having 12 to 22 carbon atoms, a surfactant, and a thickener; a step of providing a predetermined time after applying; and a step of applying a cuticle care agent after the predetermined time.

Abstract: A combination of at least one selected dicarboxylic acid having 2 to 10 carbon atoms, in combination with at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, form a bleaching paste in order to reduce the damage to keratinic fibres caused by an oxidative bleaching treatment.

Abstract: A cosmetic product for hair dyeing or hair bleaching comprising a first agent containing an alkali agent and a second agent containing hydrogen peroxide, wherein viscosity of any one of the first agent and the second agent is 100 mPa·s or less, and viscosity of the other agent is 1000 mPa·s or more, the cosmetic product comprising components (A) to (D) in a mixture of the first agent and the second agent, wherein the mass ratio of [(B)+(C)]/(A) in the mixture is 2 or more and 11 or less: (A) a polymer containing a diallyl quaternary ammonium salt as a constitutional unit and having a charge density of 2.

Abstract: A combination of at least one select dicarboxylic acid having 2 to 10 carbon atoms, in combination with at least one amino acid, selected from arginine, lysine, histidine or at least one of the salts of these amino acids, are included in a blonding powder to reduce the damage caused to keratin fibers by an oxidative bleaching treatment.

Abstract: The invention relates to a compound inhibiting the interaction between a Grb14 protein and an insulin receptor of Formula (I) or Formula (II), their salts, solvates, and/or diastereoisomers, for use for therapeutic purposes, in particular for the treatment of insulin resistance, and to pharmaceutical compositions containing such compounds.

Abstract: A subject of the present disclosure is a cosmetic agent to lighten keratinous fibers containing—relative to its total weight— (A) from about 12.0 to about 23.0 wt. % potassium peroxodisulfate and (B) from about 10.0 to about 20.0 wt. % ammonium peroxodisulfate and (C) from about 5.0 to about 15.0 wt. % sodium peroxodisulfate. A second subject of the present disclosure is a method for lightening keratinous fibers, particularly red and/or reddish-blond keratinous fibers, wherein an agent of the first subject of the present disclosure is mixed with at least one additional component containing hydrogen peroxide and applied to the hair.

Abstract: A method for producing dihydroxyindoles includes: a step 1 of obtaining an aqueous first solution including dihydroxyindoles obtained by causing at least a material selected from the group consisting of 3-(3,4-dihydroxyphenyl)alanine and a derivative of 3-(3,4-dihydroxyphenyl)alanine to react with an oxidizing agent; and a step 2 of obtaining an oleaginous second solution in which the dihydroxyindoles are extracted in an extraction solvent by mixing the first solution obtained in the step 1 with the extraction solvent. Before the first solution obtained in the step 1 is mixed with the extraction solvent in the step 2, a water-insoluble by-product is removed from the first solution.

Abstract: A first subject of the present disclosure is a special oxidant preparation for oxidative coloring of keratinous fibers, more particularly human hair, included in a cosmetic carrier (A) hydrogen peroxide and (B) at least one acid from the group of sulfuric acid, hydrochloric acid, phosphoric acid, lactic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, oxalic acid, ascorbic acid, phytic acid, gluconic acid, nitric acid, malonic acid, acetic acid and-or C3-C22 alkane carboxylic acids, wherein the oxidant preparation has a pH value of from about 0.5 to about 3.0. Additional subjects of the present disclosure are methods for oxidative color changing of human hair in which this special oxidant preparation is used.

Abstract: Disclosed is a cosmetic treatment method for the skin, in particular for preventing and/or repairing the signs of skin ageing, that includes administering, and in particular applying topically to the skin, a composition containing, in a cosmetically acceptable vehicle, a compound of general formula (I): (formula I) in which R1, R2, R3, R4, R5, R6, R7 and R8, which may be identical or different, each represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, or an —OR? radical in which R? represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, at least one group from R1, R2, R3, R4, R5, R6, R7 and R8 not representing a hydrogen atom or a halogen atom, Z represents a covalent bond or a spacer arm, or one of the salts of same.

Abstract: Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.

Abstract: Aqueous surfactant compositions containing one or more alpha-sulfo fatty acid disalt (A) of general formula (I), R1CH(SO3M1)COOM2??(I), in which the radical R1 is a linear or branched alkyl or alkenyl radical having 6 to 18 carbon atoms and the radicals M1 and M2, independently of one another, are selected from the group comprising H, Li, Na, K, Ca/2, Mg/2, ammonium, and alkanolamine; one or more isethionate (B) of general formula (II), R18—COO—CHR19—CHR20—SO3M11??(II) wherein the radical R18 is a linear or branched alkyl or alkenyl radical having 7 to 19 carbon atoms and radicals R19 or R20, independently of each other, are hydrogen or an alkyl radical having 1 to 6 carbon atoms, with the proviso that not both radicals R19 and R20 are an alkyl radical, and wherein the radical M11 is selected from the group comprising H, Li, Na, K, Ca/2, Mg/2, ammonium, and alkanolamine, and water are disclosed.

Abstract: A method of reducing the appearance of hyperpigmented skin or inflamed skin is disclosed. The method can include topically applying to hyperpigmented skin or inflamed skin a composition comprising an effective amount of an extract of Rhododendron ferrugineum leaf to reduce melanocyte pigmentation in the skin or to reduce tumor necrosis factor alpha (TNF-?) and cyclooxygenase-1 and -2 (COX-1 and COX-2) activity in the skin.

Abstract: A hair coloring mixture including a carrier liquid with alumino-silicate micro-tubes having a hair dye agent loaded into the lumen of the micro-tubes. The micro-tubes may be present in the carrier liquid in a concentration of between about 5 mg/ml and about 100 mg/ml, while the mixture will have a pH of between about 4 and about 7.

Abstract: The present specification relates to a composition containing novel (20S,24R)-6-O-?-D-glucopyranosyl(1?2)-?-D-glucopyranoside-dammar-3-one-20,24-epoxy-6a,12b,25-triol, a pharmaceutically acceptable salt thereof, a hydrate or a solvate thereof as an active ingredient. The composition exhibits an excellent skin brightening effect.

Abstract: The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.