Extract Or Material Containing Or Obtained From A Micro-organism As Active Ingredient (e.g., Bacteria, Protozoa, Etc.) Patents (Class 424/780)
  • Patent number: 11268064
    Abstract: The present invention relates to heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder, a preparation method therefor and a use thereof. The heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder of the present invention has an excellent therapeutic effect for atopic diseases, and particularly has high industrial applicability because membrane adhesion competitiveness, which is an advantage of existing lactic acid bacteria, is significantly improved, thereby exhibiting dermatitis preventing, alleviating and treating effects of the same level as steroid-based drugs.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: March 8, 2022
    Assignee: IL DONG PHARMACEUTICAL CO., LTD.
    Inventors: Seung-Hun Lee, Dae-Jung Kang, Jae-Hoon Kang
  • Patent number: 11180773
    Abstract: Disclosed herein are the nucleotide sequences of the Chromobacterium subtsugae genes. In addition, the amino acid sequences of proteins encoded by the C. subtsugae genes are provided. Nucleic acids, vectors and polypeptides comprising the aforementioned sequences are also provided. Homologues, functional fragments and conservative variants of the aforementioned sequences are also provided. Compositions having pesticidal, bioremedial and plant growth-promoting activities comprising C. subtsugae genes and proteins, and methods for the use of these compositions, are also provided.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: November 23, 2021
    Assignee: MARRONE BIO INNOVATIONS, INC.
    Inventors: Ana Lucia Cordova-Kreylos, Scott Burman, Debora Wilk
  • Patent number: 10953051
    Abstract: Described are microorganisms which are, in a first aspect, able to to stimulate the growth of microorganisms of the resident skin microbial flora and which do not stimulate the growth of microorganisms of the transient pathogenic micro flora. In a second aspect microorganisms are described which are able to inhibit the growth of microorganisms of the transient pathogenic skin micro flora and which do not inhibit the growth of microorganisms of the resident skin micro flora. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: March 23, 2021
    Assignee: Novozymes A/S
    Inventors: Christine Lang, Andreas Hellmann, Markus Veen, Budde Eckhard, Mewes Boettner, Andreas Reindl, Rolf Knoll
  • Patent number: 10874722
    Abstract: The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of Clostridial toxins, such as a botulinum neurotoxin, to a patient suffering from a headache pain, where the location of administration of the botulinum toxin is based upon at least one suture line of the patient's skull.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: December 29, 2020
    Assignee: Allergan, Inc.
    Inventor: Andrew M. Blumenfeld
  • Patent number: 10787625
    Abstract: Provided here is an enzymatic process for extraction of oil from algae biomass. The oils produced by the processes herein are used in animal feed and human consumption.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: September 29, 2020
    Assignee: Bunge Global Innovation LLC
    Inventors: Christopher L. G. Dayton, Ellen Cristina de Mello Lazarini, Jean Ricardo de Souza, Karen Carvalho, Eloisa Zanin Pytlowanciv, Bruna Montalvão Lima Ferraz
  • Patent number: 10709772
    Abstract: This invention relates to improved uses of botulinum neurotoxins in the treatment of sialorrhea or diseases or conditions relating to increased saliva production. In particular are botulinum neurotoxins disclosed which are administered into parotid and submandibular glands in a dose ratio between 1.45 to 1 and 1.7 to 1.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: July 14, 2020
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Janos Csikos, Irena Pulte, Michael Althaus, Markus Krüer, Nico Wegener
  • Patent number: 10667525
    Abstract: The present disclosure includes proteins toxic to Zebra mussels, its method of production, and uses thereof. The protein was isolated from whole cell broth of Pseudomonas protegens CL145A via anion exchange chromatographic fractionation. The protein was found to be a secondary metabolite with highest expression at the fermentative production harvest stage.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: June 2, 2020
    Assignee: Marrone Bio Innovations, Inc.
    Inventor: Matt Boston
  • Patent number: 10471150
    Abstract: Disclosed herein are materials, means and methods for sustained release of therapeutic agents for topical treatments. In particular, disclosed are means and methods for topical treatment of diseases of internal body cavities by embedding therapeutic agents in a slowly degrading biocompatible mixture applied to affected tissue.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: November 12, 2019
    Assignee: UroGen Pharma Ltd.
    Inventors: Marina Konorty, Gil Hakim
  • Patent number: 10443033
    Abstract: The present invention relates to heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder, a preparation method therefor and a use thereof. The heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder of the present invention has an excellent therapeutic effect for atopic diseases, and particularly has high industrial applicability because membrane adhesion competitiveness, which is an advantage of existing lactic acid bacteria, is significantly improved, thereby exhibiting dermatitis preventing, alleviating and treating effects of the same level as steroid-based drugs.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: October 15, 2019
    Assignee: IL DONG PHARMACEUTICAL CO., LTD.
    Inventors: Seung-Hun Lee, Dae-Jung Kang, Jae-Hoon Kang
  • Patent number: 10421976
    Abstract: Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the polypeptides, DNA constructs and vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the polypeptides. Nucleotide sequences encoding the polypeptides can be used in DNA constructs or expression cassettes for transformation and expression in organisms of interest. The compositions and methods provided are useful for producing organisms with enhanced pest resistance or tolerance. Transgenic plants and seeds comprising a nucleotide sequence that encodes a pesticidal protein of the invention are also provided. Such plants are resistant to insects and other pests. Methods are provided for producing the various polypeptides disclosed herein, and for using those polypeptides for controlling or killing a pest.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: September 24, 2019
    Assignee: AGBIOME, INC.
    Inventors: Jessica Parks, Kira Bulazel Roberts, Rebecca E. Thayer
  • Patent number: 10363218
    Abstract: A method of preparing probiotic nanoparticles can include dissolving formulated probiotics in methanol, spraying the methanol solution into boiling water under ultrasonic conditions to provide a sonicated solution, and stirring the sonicated solution to obtain probiotic nanoparticles. The probiotic nanoparticles may be cluster or rod-shaped. The probiotic nanoparticles may be administered to a subject to reduce oxidative stress or to treat diseases associated with oxidative stress.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: July 30, 2019
    Assignee: King Saud University
    Inventors: Promy Virk, Manal Ahmed Gasmelseed Awad, Amnah El-Enazy, Awatif Ahmed Hendi, Mai Abdelrahman Elobeid Wagealla, Rabia Qindeel
  • Patent number: 10220079
    Abstract: The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of Clostridial toxins, such as a botulinum neurotoxin, to a patient suffering from a headache pain, where the location of administration of the botulinum toxin is based upon at least one suture line of the patient's skull.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: March 5, 2019
    Assignee: Allergan, Inc.
    Inventor: Andrew M. Blumenfeld
  • Patent number: 10214568
    Abstract: Provided is a preparation method for phycocyanin, including: adding chitosan to a suspension of cyanobacteria containing phycocyanin; and filtering the suspension.
    Type: Grant
    Filed: December 25, 2012
    Date of Patent: February 26, 2019
    Assignees: Ezaki Glico Co., Ltd., Glico Nutrition Co., Ltd.
    Inventors: Iwao Kojima, Koji Odan, Masahiro Nishikawa
  • Patent number: 10167484
    Abstract: The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: January 1, 2019
    Assignee: Monsanto Technology LLC
    Inventors: James A. Baum, Larry A. Gilbertson, David K. Kovalic, Thomas J. LaRosa, Maolong Lu, Tichafa R. I. Munyikwa, James K. Roberts, Wei Wu, Bei Zhang
  • Patent number: 10085997
    Abstract: The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Richard L. Gallo, Teruaki Nakatsuji
  • Patent number: 9827297
    Abstract: The present invention utilizes patient-specific landmarks in order to treat headache pain. In one aspect, the present invention relates to the administration of Clostridial toxins, such as a botulinum neurotoxin, to a patient suffering from a headache pain, where the location of administration of the botulinum toxin is based upon at least one suture line of the patient's skull.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: November 28, 2017
    Assignee: Allergan, Inc.
    Inventor: Andrew M. Blumenfeld
  • Patent number: 9758760
    Abstract: The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: September 12, 2017
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Michael J. Daly, Elena K. Gaidamakova
  • Patent number: 9629882
    Abstract: The invention discloses a bacterial strain of non pathogenic Cobetia marina useful in aquaculture, corresponding to an isolated Cobetia marina strain, Gram negative, oxidase positive, deposited under registry number CECT N°7764; grows with dibenzothiophene (DBT) as the only carbon source. Also disclosed is a method to obtain a biosurfactant surfactant extract comprising growing strain Cobetia marina (MM1IDA2H-1) CECT N° 7764 in a reactor with liquid growth medium from 24 to 48 hours at a temperature between 10 and 35° C., pH 6 to 8; constant stirring between 100 to 400 rpm and oxygen saturation between 10 to 21%; until obtaining a grown cell culture and extracellular products plus inorganic salts; separating the cells, lyophilizing supernatant, sieve the obtained powder and dry.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: April 25, 2017
    Assignee: UNIVERSIDAD DE VALPARAISO
    Inventors: Miguel Alejandro Dinamarca Tapia, Juan Ricardo Ojeda Herrera, Claudia Jimena Ibacache Quiroga
  • Patent number: 9598673
    Abstract: Methods and compositions for treating or ameliorating lower back pain by administering an effective amount of one or more cell types, alone, and/or in combination with a matrix, and/or in combination with growth factors, in order to stimulate lumbar angiogenesis, decrease inflammation, and stimulating regeneration.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: March 21, 2017
    Assignee: Creative Medical Health
    Inventor: Thomas E. Ichim
  • Patent number: 9555082
    Abstract: Disclosed is a composition containing Saccharomyces cerevisiae var boulardii and the enzyme superoxide dismutase.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: January 31, 2017
    Assignee: Gnosis S.p.A.
    Inventors: Ignazio Castagliuolo, Paola Brun, Immacolata Busiello, Niccolo Miraglia
  • Patent number: 9486401
    Abstract: The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. In preferred embodiments, the methods and agents comprise active extracts produced from fish eggs. The invention further provides processes for making active fish egg extracts.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: November 8, 2016
    Assignee: REGENICS AS
    Inventors: Runhild Gammelsaeter, Jan Remmereit
  • Patent number: 9480731
    Abstract: The invention relates to the use of an animal-protein-free botulinum toxin composition to treat a disease, disorder or condition in a patient in need thereof whereby the animal-protein-free botulinum toxin composition exhibits a longer lasting effect in the patient compared to an animal-protein-containing botulinum toxin composition.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 1, 2016
    Assignee: Medy-Tox, Inc.
    Inventors: Hyun Ho Jung, Gi Hyeok Yang, Hyun Jee Kim, Chang Hoon Rhee
  • Patent number: 9439953
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: September 13, 2016
    Assignee: VSL PHARMACUETICALS, INC.
    Inventor: Claudio De Simone
  • Patent number: 9364413
    Abstract: Surfactin is a biosurfactant produced by Bacillus subtilis and is a natural cycloaliphatic peptide having a ring structure made of 7 amino acids. The surfactin has various functions including anti-aging, anti-wrinkle, increasing skin penetration of cosmetic products (skin penetration agent), foaming agent, and emulsifier.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: June 14, 2016
    Assignees: UMO INTERNATIONAL CO., LTD.
    Inventors: Jenn-Kan Lu, Hsin-Mei Wang, Xuan-Rui Xu
  • Patent number: 9340587
    Abstract: This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: May 17, 2016
    Assignee: Revance Therapeutics, Inc.
    Inventors: Stewart A. Thompson, Curtis L. Ruegg, Jacob M. Waugh
  • Publication number: 20150125395
    Abstract: A method for changing a condition of an eyelid of a mammal excluding a human, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.
    Type: Application
    Filed: June 18, 2013
    Publication date: May 7, 2015
    Applicant: SANTEN PHARMACEUTICAL CO., LTD.
    Inventors: Hideki Miyake, Tomoko Oda
  • Publication number: 20150128306
    Abstract: The invention provides a method for producing steviol glycosides. The invention provides a transformant having introduced therein the steviol glucosyltransferase and a method for producing steviol glycosides using the transformant.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 7, 2015
    Applicant: SUNTORY HOLDINGS LIMITED
    Inventor: Eiichiro Ono
  • Publication number: 20150118192
    Abstract: Provided is a method for modulating soybean cyst nematode infestation of a plant comprising applying to the plant an effective amount of a composition comprising a Chromobacterium, Burkholderia, and/or Flavobacterium strain to modulate the soybean cyst nematode infestation. The composition may be applied directly to the seed or in a substrate for growing the plant, such as in the soil.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 30, 2015
    Inventors: Pamela Marrone, Timothy B. Johnson, Hai Su, Lijuan Xing, Phyllis Himmel
  • Patent number: 9017743
    Abstract: The present invention relates to an extract from bacterial strains useful as a treatment for disorders such as digestive or urinary tract disorders, compositions comprising the extract, and processes of making the extract from media that do not pose a risk of prion diseases.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: April 28, 2015
    Assignee: OM Pharma
    Inventors: Jacques Alain Bauer, Marco Salvagni, Jean-Pierre Leon Vigroux, Laetitia Chalvet, Carlo Chiavaroli
  • Patent number: 9005622
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: April 14, 2015
    Assignees: Forschungszentrum Borstel, Universitätsklinikum Freiburg
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Publication number: 20150093463
    Abstract: The present disclosure relates to nutritional compositions comprising a protein equivalent source, wherein 20% to 80% of the protein equivalent source includes a peptide component comprising SEQ ID NO 4, SEQ ID NO 13, SEQ ID NO 17, SEQ ID NO 21, SEQ ID NO 24, SEQ ID NO 30, SEQ ID NO 31, SEQ ID NO 32, SEQ ID NO 51, SEQ ID NO 57, SEQ ID NO 60, and SEQ ID NO 63, and 20% to 80% of the protein equivalent source comprises an intact protein, a partially hydrolyzed protein, or combinations thereof. The disclosure further relates to methods of reducing the inflammatory response and/or production of proinflammatory cytokines, i.e. Interleukin-17, by providing said nutritional compositions to a target subject.
    Type: Application
    Filed: October 14, 2014
    Publication date: April 2, 2015
    Inventors: Dirk Hondmann, Eric A.F. van Tol, Gabriele Gross, Marieke H. Schoemaker, Teartse Tim Lambers
  • Publication number: 20150093462
    Abstract: A watery lotion composition for topical application to skin comprising at least one extract from the fermentation of the microorganism Bifidobacterium, at least one extract from the fermentation of the microorganism Lactobacillus, and mineral water having at least 250 ppm of total mineral dissolved solids and a method for improving the efficacy of a watery lotion and/or a second skin care product by layering the products on the skin.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 2, 2015
    Inventors: Daniel B. Yarosh, Thomas MAMMONE
  • Patent number: 8992941
    Abstract: The present invention relates to methods of treating esophageal spasms using botulinum toxins.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: March 31, 2015
    Assignee: Allergan, Inc.
    Inventor: Andrew M. Blumenfeld
  • Publication number: 20150079043
    Abstract: Provided is the use of or compositions or formulations comprising Burkholderia species, filtrate, supernatant, extract, pesticidally active compound or metabolite derived therefrom as an insecticide, particularly against infestation of Corn Rootworm larvae, and/or as crop yield enhancer.
    Type: Application
    Filed: November 20, 2014
    Publication date: March 19, 2015
    Applicant: Marrone Bio Innovations, Inc.
    Inventors: Ratnakar Asolkar, Marja Koivunen, Pamela Marrone, Ana Lucia Cordova-Kreylos, Huazang Huang
  • Publication number: 20150079209
    Abstract: The present invention provides a diabetes-inducing bacterium and use thereof, and a reagent and a detection method for detecting the bacterium. According to the present invention, enteric colonization of the diabetes-inducing bacterium can be prevented, and diabetes can be treated and/or prevented.
    Type: Application
    Filed: September 26, 2014
    Publication date: March 19, 2015
    Applicant: AJINOMOTO CO., INC.
    Inventors: Keishi KAMEYAMA, Kikuji Itoh
  • Publication number: 20150079040
    Abstract: The invention provides probiotic bacteria and lysates thereof for use in methods of medical and cosmetic treatment. Use in the treatment of infections, including skin infections and methods involving regeneration or repair of the skin barrier are contemplated.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 19, 2015
    Inventors: Catherine O'Neill, Andrew McBain
  • Publication number: 20150072033
    Abstract: The present invention generally relates to the field of pro biotic micro-organisms, in particular to the field of non-replicating probiotic micro-organisms. Embodiments of the present invention relate to compositions comprising probiotic microorganisms that were rendered non-replicating by extrusion. Such compositions may be used to treat or prevent disorders that are related to a compromised immune system.
    Type: Application
    Filed: November 14, 2014
    Publication date: March 12, 2015
    Inventors: Annick Mercenier, Antoine Wermeille, Audrey Demont, Guenolee Prioult
  • Patent number: 8969653
    Abstract: The present application relates to extracellular vesicles (EVs) derived from gram-positive bacteria. In detail, the present application provides animal models of disease using extracellular vesicles derived from gram-positive bacteria, provides a method for screening an active candidate substance which is capable of preventing or treating diseases through the animal models of disease, provides vaccines for preventing or treating diseases caused by extracellular vesicles derived from gram-positive bacteria, and provides a method for diagnosing the causative factors of diseases caused by gram-positive bacteria using extracellular vesicles.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: March 3, 2015
    Assignee: Aeon Medix Inc.
    Inventors: Yong Song Gho, Yoon Keun Kim, Eun Young Lee, Sung Wook Hong, Ji Hyun Kim, Seng Jin Choi
  • Patent number: 8961952
    Abstract: The present invention generally relates to the field of probiotic micro-organisms, in particular to the field of non-replicating probiotic micro-organisms. Embodiments of the present invention relate to compositions comprising probiotic micro-organisms that were rendered non-replicating by extrusion. Such compositions may be used to treat or prevent disorders that are related to a compromised immune system.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: February 24, 2015
    Assignee: Nestec S.A.
    Inventors: Annick Mercenier, Antoine Wermeille, Audrey Demont, Guenolee Prioult
  • Patent number: 8956669
    Abstract: The present disclosure describes the isolation of extremophilic microorganisms from the Lakes of Schirmacher Oasis located in the East Antarctic Dronning Maud Land. The isolated organisms were characterized and certain pigments produced by these microorganisms were isolated. The present disclosure teaches that the isolated pigments exhibit anticancer and antimicrobial properties and can be used as new therapies for the treatment and prevention of cancer and microbially-mediated diseases.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: February 17, 2015
    Assignee: The UAB Research Foundation
    Inventor: Asim Bej
  • Publication number: 20150044188
    Abstract: Molecules secreted or derived from probiotic bacteria are provided for use in compositions and methods for the treatment and/or prevention of infection by pathogenic viruses. The isolated secreted molecules can also be used in nutritional or medical food products which provide probiotics to the gastrointestinal tract of a mammal.
    Type: Application
    Filed: August 12, 2014
    Publication date: February 12, 2015
    Inventor: Mansel Griffiths
  • Publication number: 20150044317
    Abstract: The present invention relates to the use of lactic acid producing bacteria and the extracellular product thereof in topical compositions.
    Type: Application
    Filed: August 28, 2014
    Publication date: February 12, 2015
    Inventors: Sean Farmer, Michael A. Bush, David Keller, Andrew R. Lefkowitz, Howard Cash
  • Patent number: 8951585
    Abstract: Provided is a method for modulating soybean cyst nematode infestation of a plant comprising applying to the plant an effective amount of a composition comprising a Chromobacterium, Burkholderia, and/or Flavobacterium strain to modulate the soybean cyst nematode infestation. The composition may be applied directly to the seed or in a substrate for growing the plant, such as in the soil.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: February 10, 2015
    Assignee: Marrone Bio Innovations, Inc.
    Inventors: Pamela Marrone, Timothy B. Johnson, Hai Su, Lijuan Xing, Phyllis Himmel
  • Publication number: 20150037364
    Abstract: Baboon Adenovirus (BaAdV)-2/4 and BaAdV-3 are disclosed herein. BaAdV-2/4 and BaAdV-3 polynucleotide, polypeptides and antibodies that specifically bind BaAdV-2/4 and/or BaAdV-3 are disclosed. Methods are disclosed for detecting BaAdV-2/4 and BaAdV-3. Methods are also disclosed for treating, preventing, and inducing an immune response to BaAdV-2/4 and/or BaAdV-3. Kits are also provided.
    Type: Application
    Filed: January 15, 2014
    Publication date: February 5, 2015
    Inventors: Charles Chiu, Jean Patterson, Mary Michelle Leland, Kenneth Dee Carey, Dean Ehrdman
  • Publication number: 20150031534
    Abstract: Provided is a pesticidal Flavobacterium strain and bioactive compositions and metabolites derived therefrom as well as their methods of use for controlling pests.
    Type: Application
    Filed: March 13, 2013
    Publication date: January 29, 2015
    Inventors: Ratnakar Asolkar, Ana-Lucia Cordova-Kreylos, Marja Koivunen, Margarita Rodriguez, Lijuan Xing, Pamela Marrone
  • Patent number: 8933193
    Abstract: The present invention provides isolated lantibiotics that inhibit. Gram negative and Gram positive microbes. The antibiotic includes an amino acid sequence, wherein the amino acid sequence of the compound and the amino acid sequence of SEQ ID NO:21 or SEQ ID NO:22 have at least 80% identity. The lantibiotics have the characteristic of inhibiting growth of a Gram negative microbe in conditions that do not damage the outer membrane of the Gram negative microbe. The present invention also provides methods for making and using the lantibiotics.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: January 13, 2015
    Assignee: Regents of the University of Minnesota
    Inventors: Daniel J. O'Sullivan, Ju-Hoon Lee
  • Patent number: 8932844
    Abstract: The invention induces an increase in the resistance of potato plants, without apparent toxicity for the plant. Preliminary experiments indicate that the increase in metabolism of plants efficiently fosters (above 60%) the reduction of the development of the pathogenic phytobacteria, Erwinia carotovora, one of the principal agents in causing diseases in potatoes.
    Type: Grant
    Filed: October 19, 2013
    Date of Patent: January 13, 2015
    Assignee: Uniao Brasileira de Educacao e Assistencia—Mantenedora da PUCRS
    Inventors: Leandro Vieira Astarita, Fernando Rostirolla Dalmas, Vera Aparecida Dus Poiatti
  • Publication number: 20140348878
    Abstract: A strain of exopolysaccharide-secreting Lactobacillus brevis, BDLB0001, and an application thereof. The Lactobacillus brevis is deposited at the China General Microbiological Culture Collection Center of the China Committee of Culture Collection for Microorganisms, with a deposit number of CGMCC No. 5223. The Lactobacillus brevis secrets an elevated amount of exopolysaccharide, where the exopolysaccharide secreted is capable of eliciting B lymphocyte proliferation to enhance immunity, and has application prospects in medicaments, healthcare products and food products for immunity enhancement.
    Type: Application
    Filed: April 25, 2012
    Publication date: November 27, 2014
    Applicant: BRIGHT DAIRY & FOOD CO., LTD.
    Inventors: Lianzhong Ai, Benheng Guo, Kejie Sun, Wei Chen, Hao Zhang, Li Shao, Zhengjun Wu, Wanyi Chen, Haibo Mu
  • Publication number: 20140341921
    Abstract: Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.
    Type: Application
    Filed: November 29, 2012
    Publication date: November 20, 2014
    Applicants: The University of Tokyo, School Corporation , Azabu Veterinary Medicine Educational Institution
    Inventors: Kenya Honda, Koji Atarashi, Takeshi Tanoue, Masahira Hattori, Hidetoshi Morita
  • Publication number: 20140341852
    Abstract: Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications.
    Type: Application
    Filed: March 14, 2014
    Publication date: November 20, 2014
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Arun Srivastava, George V. Aslanidi, Sergei Zolotukhin, Mavis Agbandje-McKenna, Kim M. Van Vliet, Li Zhong, Lakshmanan Govindasamy