Extract Or Material Containing Or Obtained From A Micro-organism As Active Ingredient (e.g., Bacteria, Protozoa, Etc.) Patents (Class 424/780)
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Publication number: 20100291192Abstract: The invention relates to a method of detoxifying a lipopolysaccharide (LPS) or a lipid A from a Gram-negative bacterium, which comprises mixing the LPS or the lipid A with a cationic lipid so as to form a complex in which the LPS or the lipid A is associated with the cationic lipid. According to the conventional preparation modes, the cationic lipid with the co-lipid, if this latter is present, get(s) structured into complexes i.a. liposomes. When preparing lipidic complexes, the addition of LPS or Lipid A leads to an association of this latter with the cationic lipid and as a result, the LPS or lipid A is substantially detoxified. The LPS or lipid A detoxified by the complexes, e.g. when incorporated into liposomes, can be used as vaccinal antigen or as adjuvant.Type: ApplicationFiled: May 14, 2010Publication date: November 18, 2010Applicant: Sanofi PasteurInventors: Jean Haensler, François Dalençon, Monique Moreau, Noëlle Mistretta
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Publication number: 20100291007Abstract: The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.Type: ApplicationFiled: January 26, 2010Publication date: November 18, 2010Applicant: SOCIETE L'OREAL S.A.Inventors: Yann Mahe, Alain Meybeck
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Publication number: 20100291251Abstract: The present invention provides a composition comprising a high content of highly pure, low-cost, and safe carotenoid and a method for industrially producing the same. The present invention also provides functional food, a pharmaceutical composition and a cosmetic product comprising such a composition. The present invention further provides a method for producing a composition containing at least 80% of carotenoid, which is characterized in treating a microorganism culture with extraction using a lower alcohol at 80° C. at the lowest or a combination of water and a lower alcohol at 80° C. at the lowest, and then washing and filtrating the precipitate obtained from the extract solution with a combination of a lower alcohol and water.Type: ApplicationFiled: August 29, 2008Publication date: November 18, 2010Applicant: Nippon Oil CorporationInventors: Toshiyuki Takahashi, Shotaro Uchizawa, Hideyuki Dohi, Kentaro Shimizu, Tomoyuki Ishizaki
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Publication number: 20100291025Abstract: The present invention relates to new indazole inhibitors of tyrosine kinase activity, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: April 13, 2010Publication date: November 18, 2010Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Tadimeti Rao, Chengzhi Zhang
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Publication number: 20100278793Abstract: The present invention relates to the cosmetic treatment of greasy skin and/or skin that tends to be greasy with a lysate of at least one microorganism of the genus Bifidobacterium species and/or a fraction thereof, as an active.Type: ApplicationFiled: October 28, 2009Publication date: November 4, 2010Applicant: L'OREALInventors: Audrey Gueniche, Isabelle Castiel, Dominique Bernard
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Publication number: 20100272839Abstract: The present invention treats a fatty dandruff state of the scalp with a lysate of at least one microorganism of the genus Bifidobacterium species and/or a fraction thereof.Type: ApplicationFiled: October 28, 2009Publication date: October 28, 2010Applicant: L'OREALInventors: Audrey GUENICHE, Dominique Bernard, Isabelle Castiel
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Publication number: 20100266717Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.Type: ApplicationFiled: April 20, 2010Publication date: October 21, 2010Applicant: Marrone Bio Innovations, Inc.Inventors: Ratnakar Asolkar, Sarahann Dow, Huazhang Huang, Marja Koivunen, Pamela Marrone, Stephanie Shu
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Publication number: 20100254956Abstract: The present invention provides methods for manufacturing heat treated products involving the use of probiotic bacteria, e.g. lactic acid bacteria and/or Bifidobacteria, cultures of such bacteria, supernatant from such cultures, and/or concentrates of such supernatant and/or fractions of such supernatant. The invention further provides heat treated products of such processes and their use for regulation of cellular uptake of fat and/or triglycerides and/or body weight management or weight reduction and/or redistribution of fat and/or reduction in visceral and/or abdominal fat deposition in a subject.Type: ApplicationFiled: December 5, 2008Publication date: October 7, 2010Inventors: Velmurugesan Arulampalam, Joseph James Rafter, Sven Pettersson
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Publication number: 20100255052Abstract: The present invention refers to an Integrated Implant System constituted as a gel-matrix-cells integrated system, that allows providing implants in a brief time period, for covering a great skin extension to be treated, with a successful acceptance in patients with burns, chronic damage or wound skin, needing of a skin grafting.Type: ApplicationFiled: June 7, 2007Publication date: October 7, 2010Inventors: Manuel Eduardo Young Anze, Cristian Andrés Acevedo Gutiérrez, Fernando Antonio Albornoz Marquez, Caroline Ruth Weinstein Oppenheimer, Alexis Roobins Aceituno Alvarez, Donald Irving Brown Gonzalez, Sergio Miguel Tapia Murua
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Patent number: 7803411Abstract: A physiologically active substance NK13650P3 having the following physicochemical properties or a pharmacologically acceptable salt thereof. 1) Appearance: pale yellow powder 2) Molecular formula: C29H37N7O15 3) Molecular weight: 723 4) Hydrogen nuclear magnetic resonance spectrum: spectrum measured at 600 MHz in heavy water contains the following signals: chemical shift value ? ppm: 7.05 (1H, 3), 7.00 (1H, d), 6.96 (1H, d), 6.83 (1H, s), etc. 5) Carbon nuclear magnetic resonance spectrum: spectrum measured at 150 MHz in heavy water contains the following signals: chemical shift value ? ppm: 181.5(s), 181.4(s), 179.9(s), 179.2(s), 174.5(s), 174.3(s), 171.5(s), 165.4(s), etc. 6) Ultraviolet light spectrum: spectrum measured in aqueous solution contains the following UV absorption bands: ?max (MeOH): 196.5 nm, 224.5 nm, 322.5 nm 7) Solubility: highly soluble in water but insoluble in methanol, acetone, ethyl acetate, chloroform and dimethyl sulfoxide.Type: GrantFiled: June 26, 2006Date of Patent: September 28, 2010Assignee: Nippon Kayaku Kabushiki KaishaInventors: Arihiro Tomura, Junko Odanaka, Masakazu Nishimoto
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Publication number: 20100227013Abstract: The present invention relates to an extract from bacterial strains, such as Staphylococcus, Moraxella, Klebsiella, Streptococcus, and Haemophilus. The extract is useful as a treatment for indications such as respiratory disorders, compositions comprising the extract, and processes of making the extract from media that do not pose a risk of prion diseases.Type: ApplicationFiled: March 5, 2008Publication date: September 9, 2010Inventors: Jacques Alain Bauer, Marco Salvagni, Jean-Pierre Leon Vigroox, Laetitia Chalvet, Carlo Chiavaroli
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Publication number: 20100221227Abstract: This invention relates to compositions comprising a bacterium of the genus Dietzia that is useful for treating paratuberculosis in ruminants and to a method for culturing the bacterium. The invention further relates to methods of treating Johne's disease by administering to a mammal a composition of the invention.Type: ApplicationFiled: March 5, 2010Publication date: September 2, 2010Inventor: Robert E. Click
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Patent number: 7781193Abstract: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained.Type: GrantFiled: July 24, 2007Date of Patent: August 24, 2010Assignee: Martek Biosciences CorporationInventors: Craig M. Ruecker, Swithwin Patrick Adu-peasah, Brian S. Engelhardt, George T. Veeder, III
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Publication number: 20100209410Abstract: Fungicidal mixtures, comprising 1) a fungicidal strain (I) selected from a) the Bacillus substilis strain with NRRL Accession No. B-21661, and b) the Bacillus pumilus strain with NRRL Accession No. B-30087, or a mutant of these strains having all the identifying characteristics of the respective strain, or a metabolite produced by the respective strain that exhibits activity against plant pathogenic fungi, and 2) at least one chemical compound II, selected from the active compound groups A) to F): A) azoles; B) strobilurins; C) carboxamides; D) heterocyclic compounds; E) carbamates; F) other fungicides; in a synergistically effective amount, methods for controlling harmful fungi using compositions of components 1) and 2), the use of a component 1) with a component 2) for preparing such compositions, and also fungicidal agents and seed comprising such compositions.Type: ApplicationFiled: September 16, 2008Publication date: August 19, 2010Applicant: BASF SEInventors: Ulrich Schoefl, Maria Scherer, Egon Haden
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Publication number: 20100209461Abstract: Disclosed herein are extracts of blue green algae, such as Aphanizomenon flos aquae, that are enriched for a selectin ligand, such as an L-selectin ligand. Selectin ligands isolated from blue-green algae cells are disclosed herein. Methods are described for isolating these selectin ligands. The purified selectin ligands are of use in inducing stem cell mobilization in a subject. Thus, methods for inducing stem cell isolation that include administering a therapeutically effective amount of the extract enriched form the selectin ligand, or an isolated selectin ligand, are disclosed herein.Type: ApplicationFiled: April 13, 2010Publication date: August 19, 2010Inventors: Gitte S. Jensen, Christian Drapeau
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Publication number: 20100203180Abstract: The present invention relates to a novel antimicrobial protein derived from bacteriophage having killing activity specific to Staphylococcus aureus, more precisely an antimicrobial protein originated from Podoviridae bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious disease in human and animals, a pharmaceutical composition for the prevention and treatment of infectious disease caused by Staphylococcus aureus, an antibiotic and a disinfectant containing the bacteriophage-originated antimicrobial protein as an active ingredient.Type: ApplicationFiled: February 12, 2009Publication date: August 12, 2010Applicant: iNtRon Biotechnology, Inc.Inventors: Seongjun Yoon, Yunjaie Choi, Seyung Lee, Jeesoo Son, Sooyoun Jun, Sanghyeon Kang
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Publication number: 20100196524Abstract: The present invention relates to the fields of life sciences and food, feed or pharmaceutical industry. Specifically, the invention relates to novel peptides, pilus structures, polynucleotides as well as vectors, host cells, products and pharmaceutical compositions comprising the polynucleotides, peptides or pilus structures. The invention also relates to gene clusters and antibodies. Furthermore, the present invention relates to methods for producing the peptides or pilus structures or producing the products comprising the peptides or pilus structures. Furthermore, the present invention relates to treatments as well as uses and methods for screening bacterial strains, for reducing or inhibiting the adhesion of pathogenic bacteria, promoting the adhesion of bacterial cells to the mucus and for modifying immune response in a subject. Still, the present invention relates to methods for detecting probiotic bacterial strains or pathogen strains.Type: ApplicationFiled: February 2, 2009Publication date: August 5, 2010Applicant: VALIO LTD.Inventors: Willem MEINDERT DE VOS, Airi Palva, Ilkka Palva, Justus Reunanen, Ingemar Von Ossowski, Reetta Satokari, Satu Vesterlund, Matti Kankainen, Tuomas Salusjarvi, Soile Tynkkynen
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Publication number: 20100183559Abstract: The multiple embodiments described herein comprise the genome of a probiotic Bifidobacterium longum bifidobacteria strain and genes encoded by the genome. Various novel Bifidobacterium longum are described.Type: ApplicationFiled: November 11, 2009Publication date: July 22, 2010Applicants: Alimentary Health Limited, The Procter & Gamble CompanyInventors: Douwe Van Sinderen, Jun Xu, Wenzhu (Steven) Zhao, Raymond A. Grant, Song Yuli, Charles Bascom, Duane Larry Charbonneau, Liam O'Mahony
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Publication number: 20100178371Abstract: Compositions comprising L-tryptophan and/or 5-hydroxytryptophan are used for preparing a product suitable for sublingual or nasal administration which is helpful in suppressing appetite in such a manner as to promote weight loss in an individual; such compositions furthermore exhibit an antidepressant activity and an antiasthenic effect which makes them helpful in improving tone and mood and the level of attention in an individual. The compositions preferably comprise phenylethylamine in a synergistic combination which substance is contained in an algal plant extract, preferably of Klamath algae.Type: ApplicationFiled: June 3, 2008Publication date: July 15, 2010Inventor: Giulia Federica Merizzi
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Patent number: 7754253Abstract: The use of botulinum toxin for preparing a drug for preventing hair growth is disclosed. A cosmetic method for preventing hair growth is also disclosed.Type: GrantFiled: March 2, 2005Date of Patent: July 13, 2010Assignee: Ipsen Pharma S.A.S.Inventor: Claude LeLouarn
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Patent number: 7749513Abstract: The present invention relates to cholesterol-lowering preparations, in particular to a bacterial preparation for use as a medicament for lowering of the blood cholesterol level. The present invention provides inter alia a preparation of Rhodospirillum spp. and/or Phaeospirillum with cholesterol-lowering effects, food supplements and foodstuffs comprising said preparation and methods for the preparation and use thereof.Type: GrantFiled: February 10, 2009Date of Patent: July 6, 2010Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNOInventors: Josephus Jan Emeis, Christophe Lasseur
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Publication number: 20100166814Abstract: The present invention relates to a cosmetic composition, which comprises a combination of at least two osmolytes chosen from the group comprising taurine or a derivative thereof, inositol, betaine and trehalose. This composition is intended for restoring, maintaining or reinforcing the moisturization of the skin and/or for protecting it against different types of stress and/or for preventing or retarding the appearance of the signs of aging of the skin, or for attenuating the effects thereof, or alternatively for promoting cell or tissue longevity.Type: ApplicationFiled: December 22, 2009Publication date: July 1, 2010Applicant: LVMH RechercheInventors: Marc C.M. Dumas, Valérie A.S. Krzych, Delphine Pelle de Queral, Catherine Heusele
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Publication number: 20100166708Abstract: The disclosure provides methods and compositions useful for treating microbial and viral infections. In certain aspects, the compositions and methods relate to the use of an effective amount of a delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof. In other aspects, the compositions and methods relate to the use of an effective amount of Staphylococcus epidermidis or an extract of 5. epidermidis comprising delta-haemolysin and/or phenol soluble modulin-delta or functional variant thereof.Type: ApplicationFiled: February 20, 2008Publication date: July 1, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Richard L. Gallo, Victor Nizet, Anna Cogen, YuPing Lai
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Publication number: 20100160160Abstract: The subject invention provides novel and advantageous materials and methods for controlling phytopathogenic and/or soil-dwelling nematodes by attaching an effective amount of Pasteuria spores to a seed and delivering the seeds to the situs of nematodes.Type: ApplicationFiled: December 18, 2009Publication date: June 24, 2010Inventors: Thomas E. Hewlett, John P. Waters, Charles S. Barmore
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Publication number: 20100159046Abstract: A method for minimizing tissue adhesion at an injured site is provided, the method comprising applying a biocellulose material to the injured site, whereby the adhesion of the tissues at the injured site is minimized, wherein the biocellulose material is at least partially dehydrated. Another embodiment provides an implantable material, which effectively prevents cell adhesion and has desirable mechanical properties.Type: ApplicationFiled: July 1, 2009Publication date: June 24, 2010Inventors: Jeremy Harris, Constance Ace, Gonzalo Serafica
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Publication number: 20100151065Abstract: The invention relates to the cosmetic use of at least one epidermal differentiation activator for combating the effects of electromagnetic waves on the skin. The invention also relates to a cosmetic treatment process comprising the application, to the skin or the integuments, of a cosmetic composition comprising at least one epidermal differentiation activator for combating the effects of electromagnetic waves on the skin.Type: ApplicationFiled: July 24, 2006Publication date: June 17, 2010Applicant: Laboratories ClarinsInventor: Olivier Courtin
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Publication number: 20100151058Abstract: Long term weight loss can be achieved and maintained with a formulation of over-the-counter life-enhancing dietary supplements. One or more supplements stimulate the release of serotonin within the brain and one or more supplements stimulate the release of cholecystokinin into the bloodstream. The combined potentiating effect of these two mechanisms on satiety enables greater weight loss than that previously achieved by the individual mechanisms acting alone. A third weight loss mechanism can be achieved with the addition of phenylethylamine. Even more effective weight loss formulations can be achieved with the addition of a blue-green algae, such as aphanizomenon flos aqua, to provide a longer lasting weight loss mechanism.Type: ApplicationFiled: February 22, 2010Publication date: June 17, 2010Inventor: John V. Cappello
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Publication number: 20100151066Abstract: Compositions comprising L-tryptophan, 5-hydroxytryptophan and/or D-Limonene are used for preparing a product suitable for sublingual or nasal administration which is helpful in suppressing appetite in such a manner as to promote weight loss in an individual; such compositions furthermore exhibit an antidepressant activity and an antiasthenic effect which makes them helpful in improving tone and mood and the level of attention in an individual. The compositions preferably comprise phenylethylamine in a synergistic combination which substance is contained in an algal plant extract, preferably of Klamath algae.Type: ApplicationFiled: December 9, 2009Publication date: June 17, 2010Inventor: Giulia Federica MERIZZI
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Publication number: 20100150873Abstract: The present invention relates to a novel bacterium Yersinia entomophaga MH96 as deposited at DSMZ on 4 May 2006 and designated accession no. DSM 18238. The present invention also relates to substances obtained or derived from Yersinia entomophaga MH96, which retain biopesticide activity. Methods for protecting a plant from pest infestation which include applying to the plant or its environment an effective amount of Yersinia entomophaga MH96 or a product delivered from the bacterium are also described.Type: ApplicationFiled: June 8, 2007Publication date: June 17, 2010Inventors: Mark Robin Holmes Hurst, Travis Robert Glare
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Publication number: 20100135972Abstract: The invention describes the use of a microbial preparation of one or more bacteria, for example of the genus Bacillus in the manufacture of a formulation as a medicament for the treatment and prevention of infestation of sucking lice from the order Phthiraptera, Anoplura, Rhynchophthirina and/or Pediculidae. The medicament can be applied to plumage, pelage or hair to control sucking lice.Type: ApplicationFiled: March 7, 2006Publication date: June 3, 2010Applicant: Microbial Products Ply Ltd.Inventors: Dudley Edwin Pinnock, David John Cooper
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Publication number: 20100129337Abstract: Strains of Lactobacillus which have been selected for their capability of reducing gastrointestinal inflammation, such as that due to Helicobacter pylori, and products derived from these strains, including agents for treatment or prophylaxis of inflammation associated with Helicobacter pylori for administration to humans and include conditioned media in which the selected strains have grown and protein-containing extracts of the conditioned media.Type: ApplicationFiled: January 25, 2010Publication date: May 27, 2010Inventors: Eamonn Connolly, Bo Mollstam
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Publication number: 20100119613Abstract: The present invention relates to a method for producing an extract which is capable of inducing an antioxidant stress response comprising the step of treating an extract from organic material with UV light, said extract being derived from a non-mammalian cell or a non-mammalian organism and said cell or organism being capable of synthesizing polyunsaturated fatty acids. Furthermore, an extract capable of inducing an antioxidant stress response produced in accordance with the inventive methods, in particular an extract capable of inducing an antioxidant stress response for the preparation of a cosmetic composition is disclosed. The present invention also relates to a cosmetic composition comprising the inventive extract obtainable by the method provided herein.Type: ApplicationFiled: April 2, 2008Publication date: May 13, 2010Inventors: Florian Gruber, Olga Oskolkova, Erwin Tschachler, Valery Bochkov
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Patent number: 7713558Abstract: Extra-cellular product anti-biofouling against marine invertebrates which are common to the biofouling, which contains an extract of the supernatant of an Alteromonas sp. Culture. Anti-biofouling composition, comprising said extra-cellular product and a biopolymer. The use of said extra-cellular product for preparing a composition useful for inhibiting the marine micro- and macro-biofouling, and the process for preparing said extra-cellular product.Type: GrantFiled: October 14, 2005Date of Patent: May 11, 2010Assignee: Universidad de AntofagastaInventors: Carlos Eduardo Riquelme Salamanca, Fernando Rodrigo Silva Aciares, Marcela Clarke Guerra
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Publication number: 20100112100Abstract: The present invention relates, in particular, to: novel uses of a C-glycoside compound; the use, in a cosmetic composition in particular, of a C-glycoside compound in combination with at least one other skincare ingredient or active agent for improving the appearance and/or the texture of the skin; compositions comprising said combinations; or alternatively, a cosmetic or dermatological assembly comprising at least two separate compositions respectively containing, for one, the C-glycoside compound and, for the other, said cosmetic or dermatological ingredient and/or active agent; and cosmetic methods using said combinations and/or said compositions.Type: ApplicationFiled: January 11, 2010Publication date: May 6, 2010Applicant: L'OREALInventors: Claudie WILLEMIN, Laure Bissey, Jerome Senee, Delphine Compain
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Publication number: 20100111898Abstract: The present invention relates to improved methods of treating fibrotic or fibroproliferative disorders. Conjoint therapies are provided comprising the combination of one or more fibrocyte suppressors and one or more profibrotic factor antagonists or anti-fibrotic agents.Type: ApplicationFiled: December 4, 2007Publication date: May 6, 2010Applicant: PROMEDIOR, INCInventor: Timothy J. Pelura
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Patent number: 7704957Abstract: The present invention relates to a composition for inhibiting HIV activity comprising the extract of Paecilomyces sp. (Tochu-kaso) J300. More particularly, the present invention relates to a composition for inhibiting HIV activity comprising 3-[5-(methoxy-ethyl)-3,6-dioxo-piperazine-2-yl]propionic acid represented by Formula 1 and 4-methyl-2-[(pyrrolidine-2-carbonyl)-2-amino]pentanoic acid represented by Formula 2 that are extracted from Paecilomyces sp. (Tochu-kaso) J300; and to a medical composition and food composition containing the same.Type: GrantFiled: April 9, 2002Date of Patent: April 27, 2010Assignee: Rural Development AdministrationInventors: Sae-Yun Cho, Sang-Duk Ji, Seong-Kyu Song, Kwan-Hee Lee
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Publication number: 20100098728Abstract: Producing an immunostimulating composition containing lactic acid bacteria having IL-12 production-inducing activity, by culturing lactic acid bacteria belonging to the genus Lactobacillus, immediately killing the bacteria at the point of time at which the pH of the culture medium substantially stops decreasing, and then adding the obtained killed cells to a food-or-drink product.Type: ApplicationFiled: February 24, 2009Publication date: April 22, 2010Inventors: Takashi Fujiki, Kengo Kawasaki, Yoshitaka Hirose, Shinji Murosaki, Yoshihiro Yamamoto
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Publication number: 20100098795Abstract: The present invention relates to an extract from bacterial strains useful as a treatment for disorders such as digestive or urinary tract disorders, compositions comprising the extract, and processes of making the extract from media that do not pose a risk of prion diseases.Type: ApplicationFiled: March 5, 2008Publication date: April 22, 2010Inventors: Jacques Alain Bauer, Marco Salvagni, Jean-Pierre Leon Vigroux, Laetitia Chalvet, Carlo Chiavaroli
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Publication number: 20100092519Abstract: The present invention is in the field of combination therapies, including vaccine compositions, which comprise polysaccharide-protein conjugates and outer membrane vesicles (OMVs) from commensal bacteria, particularly commensal Neisseria.Type: ApplicationFiled: February 20, 2008Publication date: April 15, 2010Applicants: HEALTH PROTECTION AGENCY, SERUM INSTITUTE OF INDIA LIMITEDInventors: Andrew Richard Gorringe, Michelle Finney, Subhash V. Kapre, Akshay Goel
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Publication number: 20100080782Abstract: The present invention pertains to the use of probiotics for the preparation of a carrier for balancing the skin's immune function. In particular, the present invention pertains to the use of probiotic micro-organisms for balancing the skin's immune function under stress conditions, such as a exposure to ultraviolet radiation, specifically for enhancing the skin's immune activity and reducing the tendency to develop allergic reactions under such conditions.Type: ApplicationFiled: August 7, 2009Publication date: April 1, 2010Applicant: Nestec S.A.Inventors: Markus Baur, Lionel Breton, Francois Couzy, Audrey Gueniche
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Publication number: 20100074888Abstract: It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism.Type: ApplicationFiled: November 30, 2007Publication date: March 25, 2010Applicant: MERCK & CO., INC.Inventors: Katsumi Aragane, Ktsuya Ohbuchi, Yoshitaka Tamai, Naomoto Harada, Naomi Murai, Yoshiki Ito, Jun Kusunoki, Yukina Tokushima, Takaharu Maruyama
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Publication number: 20100068258Abstract: The invention relates to the use of an immunotherapeutic agent containing cell wall fragments of a virulent strain of Mycobacterium tuberculosis-complex (MTB-C) for the preparation of a drug for the prophylactic treatment of tuberculosis, in which said agent can be obtained using a method comprising the following steps: cultivate the virulent MTB-C strain over a period equal to or greater than three weeks; and, subsequently, homogenate the cell culture in the presence of a nonionic surfactant.Type: ApplicationFiled: October 17, 2007Publication date: March 18, 2010Applicant: ARCHIVEL FARMA, S.L.Inventors: Pere Joan Cardona Iglesias, Isabel Amat Riera
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Publication number: 20100047374Abstract: The present invention aims to provide a composition for protecting a muscle damage having high safety and a stronger muscle damage-protecting effect. The present invention provides a composition for protecting a muscle damage comprising, as an active ingredient, an extract with a lipid-soluble organic solvent of an acetic acid bacterium or preferably an extract with ethyl acetate of an acetic acid bacterium, alkali-stable lipid of an acetic acid bacterium, N-acylsphinganine, sphinganine, amino lipids, or terpenoid compounds. Further, the present invention provides a composition for protecting a muscle damage comprising, as an active ingredient, an extract with a lipid-soluble organic solvent of a vinegar or preferably an extract with ethyl acetate of a vinegar.Type: ApplicationFiled: January 16, 2007Publication date: February 25, 2010Inventors: Rena Sakakibara, Kenichi Sugiyama
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Publication number: 20100047270Abstract: Use of a composition comprising cell membrane, or hydrophobic peptides derived from said cell membrane, for the reduction of lipolytic activity, retardation of fat digestion, suppression of appetite, decrease of body weight and/or lowering of blood lipids. Satiety for fat is mainly driven from the intestine. By the contact of fat with the intestinal mucosa, various satiety peptides are released, thus suppressing appetite and food intake. A reduced rate of fat digestion could optimise the satiety for fat, through prolonged release of satiety peptides. Fat digestion can be retarded by reduction of the lipolytic activity of pancreatic lipase. The examples show that fractions of plant cell membranes (thylakoids) inhibit the lipolytic activity of pancreatic lipase.Type: ApplicationFiled: June 9, 2006Publication date: February 25, 2010Inventors: Per-Åke Albertsson, Charlotte Albertsson-Erlanson
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Patent number: 7662598Abstract: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained.Type: GrantFiled: July 24, 2007Date of Patent: February 16, 2010Assignee: Martek Biosciences CorporationInventors: Craig M. Ruecker, Swithwin Patrick Adu-peasah, Brian S. Engelhardt, George T. Veeder, III
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Publication number: 20100034908Abstract: The present invention relates to isolated Porphyromonas gingivalis polypeptides and nucleotides. The polypeptides include an amino acid sequence selected from the group consisting of: SEQ. ID. NO. 110; SEQ. ID. NO. 111; SEQ. ID. NO. 112; SEQ. ID. NO. 113; SEQ ID NO: 120; SEQ. ID. NO. 123; SEQ. ID. NO. 124; SEQ. ID. NO. 125; SEQ. ID. NO. 130; SEQ. ID. NO. 131; SEQ. ID. NO. 132; SEQ. ID. NO. 133; SEQ. ID. NO.135; SEQ. ID. NO. 136; SEQ. ID. NO. 137; SEQ. ID. NO. 138; SEQ. ID. NO. 143; SEQ. ID. NO. 144; SEQ. ID. NO. 145; SEQ. ID. NO. 146; SEQ. ID. NO. 147; SEQ. ID. NO. 148; and amino acid sequences at least 95% identical thereto.Type: ApplicationFiled: March 25, 2009Publication date: February 11, 2010Applicants: CSL Limited, The University of MelbourneInventors: Bruce C. Ross, Ian G. Barr, Michelle A. Patterson, Catherine T. Agius, Linda J. Rothel, Mai B. Margetts, Dianna M. Hocking, Elizabeth A. Webb
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Publication number: 20100034909Abstract: The present invention provides a pharmaceutical composition for treating rotavirus and/or respiratory syncytial virus infection and a method for preparing the same; wherein said pharmaceutical composition comprises a therapeutically effective amount of Spirulina extract and a pharmaceutically acceptable carrier. The Spirulina extract used in the present invention is extracted at a low temperature by the following steps: (a) adding an organic Spirulina powder into a hypotonic buffer solution and mixed well to obtain a mixture; (b) freezing the mixture from step (a) overnight at a temperature lower than 0° C.; (c) thawing the mixture from step (b); (d) separating and purifying the mixture from step (c) by a separator, and collecting blue fractions; and (e) spray drying the blue fractions from step (d).Type: ApplicationFiled: August 7, 2009Publication date: February 11, 2010Applicants: Far East Bi-Tec Co., Ltd., National Taiwan UniversityInventors: Chuang Chun Chiuh, Chun Nan Lee, Chun Ting Cheng
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Publication number: 20100028460Abstract: The present invention relates to an improved assay for identifying compounds that may be of use in conjunction with cancer chemotherapeutic agents and anti-proliferative agents, to improve efficacy of such agents and/or render effective compounds with relatively little therapeutic activity. There is also provided a class of compounds of formula (I) and retinoids identified by said assay which may be used in a combination therapy, with current and novel agents, to treat cancers and other diseases associated with abnormal host cell proliferation, such as psoriasis.Type: ApplicationFiled: July 25, 2007Publication date: February 4, 2010Inventors: Roland Wolf, John Hayes, Xiu Jun Wang
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Publication number: 20100028304Abstract: A pesticidal composition comprising synergistically effective amounts of at least one anthranilamide compound represented by the formula (I) or its salt and other pesticide: wherein each of R1a and R1b which are independent of each other, is halogen; each of R2 and R3 is halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or cyano; A is alkyl substituted by Y; Y is C3-4 cycloalkyl which may be substituted by at least one substituent selected from the group consisting of halogen, alkyl and haloalkyl; n is 0 or 1; and q is an integer of from 0 to 4; provided that R1a and R1b are not simultaneously chlorine nor bromine.Type: ApplicationFiled: December 12, 2007Publication date: February 4, 2010Applicant: ISHIHARA SANGYO KAISHA, LTD.Inventors: Toru Koyanagi, Masayuki Morita, Tetsuo Yoneda, Tsuyoshi Ueda, Kazuhisa Kiriyama, Taku Hamamoto
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Publication number: 20100021576Abstract: The present invention relates to a Bacillus amyloliquefaciens K317 strain suppressing the growth of antibiotics-resistant pathogenic microorganisms or enteropathogenic microorganisms, more precisely a Bacillus amyloliquefaciens K317 strain, a culture supernatant thereof and an antibacterial metabolite separated from the same. The Bacillus amyloliquefaciens K317 strain, the culture supernatant thereof and the antibacterial metabolite separated from the same of the invention can be effectively used for the composition, health food, and probiotics for inhibiting the growth of antibiotics-resistant pathogenic microorganisms and enteropathogenic microorganisms, since they have excellent antibacterial activity and inhibition effect on the growth of methicillin resistant pathogenic microorganism and such enteropathogenic microorganism as Edwardsiella tarda, E. coli and Staphylococcus epidermidis.Type: ApplicationFiled: November 26, 2007Publication date: January 28, 2010Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Yound-Hyo Chang, Min Young Jung, Moon-Soo Rhee