Bacterial Vaccine For Equine Species (e.g., Horses, Etc.) Patents (Class 424/829)
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Patent number: 8993252Abstract: The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.Type: GrantFiled: March 21, 2013Date of Patent: March 31, 2015Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub
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Patent number: 8911748Abstract: The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of: an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.Type: GrantFiled: May 17, 2013Date of Patent: December 16, 2014Assignee: Boise State UniversityInventor: Juliette Tinker
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Patent number: 8834898Abstract: The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.Type: GrantFiled: December 16, 2011Date of Patent: September 16, 2014Assignee: Boise State UniversityInventor: Juliette Tinker
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Patent number: 8084040Abstract: The present invention relates to the use of live attenuated bacteria for the manufacture of a vaccine for submucosal administration.Type: GrantFiled: December 1, 2010Date of Patent: December 27, 2011Assignee: Intervet International B.V.Inventors: Antonius Arnoldus Christiaan Jacobs, Daniel G. E. Goovaerts
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Patent number: 7238361Abstract: The present invention provides prodrug and multi-prodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the presence of a targeted pathophysiologic receptor. Methods for preparation and use of these prodrug complexes in drug delivery systems are also provided.Type: GrantFiled: January 6, 2006Date of Patent: July 3, 2007Assignee: Molecular Machines, Inc.Inventor: Roger S. Cubicciotti
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Patent number: 7138124Abstract: The present invention provides compositions including at least two siderophore receptor polypeptides and at least two porins from a gram negative microbe, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of makino and methods of using such compositions.Type: GrantFiled: June 3, 2003Date of Patent: November 21, 2006Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub, Donavan E. Zammert, Gayla K. Kallevig
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Patent number: 6936263Abstract: The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI—antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.Type: GrantFiled: August 16, 2002Date of Patent: August 30, 2005Assignee: Vlaams Interuniversitair Instituut voor Biotechnologie VZWInventors: Hilde Revets, Pierre Cornelis, Patrick De Baetselier
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Patent number: 6866847Abstract: A method of delivering a protein to domestic poultry by administering to the poultry by whole body spray an effective amount of a live avirulent derivative of an enteropathogenic bacterium that contains a recombinant gene encoding the protein.Type: GrantFiled: January 24, 2000Date of Patent: March 15, 2005Assignee: Megan Health, Inc.Inventor: Sandra Kelly-Aehle
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Patent number: 6682745Abstract: The present invention relates to the use of live attenuated bacteria for the manufacture of a vaccine for submucosal administration.Type: GrantFiled: January 27, 2000Date of Patent: January 27, 2004Inventors: Christiaan Antonius Arnoldus Jacobs, Danny Goovaerts
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Patent number: 6660262Abstract: A new and improved formulation and method for making same, for a broad spectrum antimicrobial treatment for bacterial and viral infections in cattle, horses, pigs, sheep and other domestic and non-domestic animals. More particularly, the present invention relates to a treatment which enables rapid relief of symptoms in an affected animal with a mortality of less than 1 percent by providing trace organic minerals in microgram quantities which act as nutrients for the animal. The treatment provides further nutritional requirements in the form of vitamin A, folic acid and vitamin D3 supplements, cobalt amino acid chelates and dried kelp, a source of minerals, amino acids, simple and complex carbohydrates, iodine and fiber. In addition, a bacterial innoculum consisting of Acidophilus species is introduced which would inhibit growth of pathogenic or opportunistic species of bacteria by competition for nutrients as well as providing for required vitamins as a by-product of metabolism.Type: GrantFiled: September 28, 2001Date of Patent: December 9, 2003Assignee: Bovine Health Products, Inc.Inventor: Randy R. McKinney
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Patent number: 6368603Abstract: Disclosed and claimed are compositions containing a Borrelia burgdorferi antigen, and methods for making and using them. The antigen can be OspA. The compositions can contain at least one additional antigen from a pathogen other than Borrelia burgdorferi. The compositions are useful for eliciting an immunological response in a host mammal susceptible to Lyme Disease and to the mammalian pathogen other than Borrelia burgdorferi. Suitable host mammals include dogs, pups, horses, and, the additional antigen can be of a canine, equine or feline pathogen, such as rabies, canine distemper, adenovirus, coronavirus, parainfluenza and parvovirus. No significant efficacy interference is observed.Type: GrantFiled: March 5, 1997Date of Patent: April 9, 2002Assignee: Merial LimitedInventor: Judy Jarecki-Black
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Patent number: 6355255Abstract: Novel vaccines for use against &bgr;-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of strepococcal C5a peptidase (SCP). Also disclosed is a method of protecting a susceptible mammal against &bgr;-hemolytic Streptococcus colonization or infection by administering such a vaccine. Enzymatically inactive SCP, and polynucleotides encoding these SCP proteins are further disclosed.Type: GrantFiled: December 7, 1998Date of Patent: March 12, 2002Assignee: Regents of the University of MinnesotaInventors: Paul Patrick Cleary, Deborah K. Stafslien
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Patent number: 6139844Abstract: A method for treating or eliminating a protozoal or parasitic disease in an animal in which a sufficient amount of a bacterial cell wall extract is administered to the animal having the protozoal or the parasitic disease. The cell wall extract is preferably a mycobacterial cell wall extract or a cornybacterium cell wall extract. The cell wall extract is most preferably a Mycobacterium phlei cell wall extract.Type: GrantFiled: April 2, 1998Date of Patent: October 31, 2000Assignee: Bioniche, Inc.Inventors: Stanley J. Alkemade, Catherine E. Hildebrand, Nigel C. Phillips, Dragan R. Rogan
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Patent number: 6120775Abstract: The present invention relates to a method of systemically administering a vaccine comprising live attenuated bacteria of the species Streptococcus equi in order to protect against Streptococcus equi infection.Type: GrantFiled: July 28, 1998Date of Patent: September 19, 2000Assignee: Akzo Nobel N.V.Inventor: Antonius Arnoldus Christiaan Jacobs
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Patent number: 6019984Abstract: Novel bacterial preparations containing one or more isolated and purified strain of a microorganism which produces one or more RTX toxins, and which strain has at least one RTX toxin which is substantially cell-associated. Methods of preparing the bacterial preparations and their use as vaccines and to produce antibodies for passive immunization are described.Type: GrantFiled: December 23, 1996Date of Patent: February 1, 2000Assignee: University of GuelphInventors: Janet MacInnes, Paul Ricciatti, Bonnie Mallard, Soren Rosendal, deceased
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Patent number: 5955090Abstract: The present invention relates to a hybrid protein comprising the Pseudomonas aeruginosa outer membrane protein I (OprI) which is fused with its amino terminal end to the carboxy-terminal end of a carboxy-terminal portion of the Pseudomonas aeruginosa outer membrane protein F (OprF), as well as to monoclonal or polyclonal antibodies against this hybrid protein. Both, the hybrid protein and the antibodies directed to the hybrid protein confer protection against an infection by Pseudomonas aeruginosa to laboratory animals or man.Type: GrantFiled: December 14, 1995Date of Patent: September 21, 1999Assignee: Chiron Behring GmbH & Co.Inventors: Bernhard Knapp, Klaus-Dieter Hungerer, Michael Broker, Bernd-Ulrich von Specht, Horst Domdey
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Patent number: 5646240Abstract: Provided by the present invention are novel diguanamine derivatives, led by 2,5/2,6-bis(4,6-diamino-1,3,5-triazin-2-yl)-bicyclo[2.2.1]heptanes and 1,3/1,4-bis(4,6-diamino-1,3,5-triazin-2-yl)-cyclohexanes, and derivatives thereof, applications of these compounds in fields such as adhesives and paints, utilization of these compounds in flame-retarding, thermal stabilization and compatibilization methods of resins, thermosetting molding compositions and thermosetting expansion-molding compositions making use of these compounds, as well as polymeric microspheres also using these compounds. These compounds are expected to find wide spread industrial utility as various excellent properties can be obtained by using them.Type: GrantFiled: March 21, 1996Date of Patent: July 8, 1997Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Tetsuya Oishi, Jin Suzuki, Kouhei Ohkawa, Hiroshi Ono