Diagnostic Or Test Agent Produces In Vivo Fluorescence Patents (Class 424/9.6)
  • Patent number: 11187651
    Abstract: Methods and devices are provided to provide clean signals even in the presence of spectral interference. At least some of these methods can be applied for cases when interfering signals are to be accounted for. These cases include, but are not limited to, hemolysis detection, icterus detection, and assays. They can be implemented in with data collected with spectrophotometers, instruments that can collect absorbance values at the few wavelengths of interest, and, in the case of the method based on background subtraction, simple imaging setups with only two filters (such as but not limited to narrow-band and wide-band) per absorption peak of interest.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: November 30, 2021
    Assignee: Labrador Diagnostics LLC
    Inventor: Toan Huynh
  • Patent number: 11185278
    Abstract: Methods, compositions and systems are provided for the imaging of cavity/tissue lesions, including without limitation cavity/tissue malignant lesions, e.g. cancers of the skin, mouth, colon, digestive system cervix, bladder, lung, etc.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: November 30, 2021
    Assignee: Orlucent, Inc.
    Inventors: Catherine M. Shachaf, Amit Shachaf
  • Patent number: 11156615
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 26, 2021
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Patent number: 11116835
    Abstract: Anti-Epstein Barr Virus (EBV) antibodies and vaccines are described herein. The antibodies and vaccines can be used to treat and/or reduce the risk of EBV infection and to treat and/or reduce the risk of complications associated with EBV infection, such as infectious mononucleosis, lymphoproliferative disorders, carcinomas, and smooth muscle tumors.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: September 14, 2021
    Assignee: Fred Hutchinson Cancer Research Center
    Inventor: Andrew McGuire
  • Patent number: 11097250
    Abstract: Methods of synthesizing crystalline metal-organic frameworks (MOFs) comprising polytopic organic linkers and cations, where each linker is connected to two or more cations, are provided. In the disclosed methods, the linkers are reacted with a compound of formula MnXm, where M is cationic Be, Mg, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Rh, Pd, Cd, or Hf, X is anionic, n and m are integers. The reacting is buffered by a buffer devoid of metal coordinating functionality when the pKa of the anion is below a threshold related to the lowest pKa of the linker. The reacting is optionally not buffered when the pKa of the anion is at or above this threshold. The disclosed methods lead to product phase MOF in which crystal growth is controlled leading to control over molecular diffusion.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: August 24, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Simon C. Weston, Jeffrey R. Long, Joseph M. Falkowski, Kristen Colwell, Rodolfo Torres
  • Patent number: 11096986
    Abstract: The present invention shows that the isolated NFL-TBS40-63 peptide is highly specific for neural stem cells. It is therefore presented here for use in a method for detecting these cells in vitro or in vivo, for addressing chemical compounds or biological materials to said cells, or for treating neurodegenerative disorders or brain tumours.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: August 24, 2021
    Assignees: Universite D'Angers, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Joel Eyer, Claire Lepinoux-Chambaud
  • Patent number: 11091646
    Abstract: Luminescent reporter compounds that are rotaxanes having the structure where B—Z—C is a reporter molecule based on a squaraine type molecule, or similar reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: August 17, 2021
    Assignee: SETA BioMedicals, LLC
    Inventors: Dmytro V. Kobzev, Olga S. Kolosova, Olena M. Obukhova, Olga M. Semenova, Rostyslav P. Svoyakov, Anatoliy L. Tatarets, Ewald A. Terpetschnig
  • Patent number: 11091643
    Abstract: The present invention is generally directed to the synthesis and use of fluorophores. It is more specifically directed to the synthesis and use of deuterated fluorophores. In one case, the present invention provides a compound of the structure shown in FIG. 44.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: August 17, 2021
    Assignee: Howard Hughes Medical Institute
    Inventors: Luke Lavis, Jonathan B. Grimm
  • Patent number: 11077210
    Abstract: The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: August 3, 2021
    Assignees: Beth Israel Deaconess Medical Center, Georgia State University Research Foundation Inc.
    Inventors: John V. Frangioni, Hak Soo Choi, Maged M. Henary
  • Patent number: 11027027
    Abstract: Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: June 8, 2021
    Assignee: Vanderbilt University
    Inventors: H. Charles Manning, Yiu-Yin Cheung, Jason R. Buck, Jun Li
  • Patent number: 11001562
    Abstract: The instant invention provides near-infrared fluorescent nerve contrast agents and methods of using them.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: May 11, 2021
    Assignees: Beth Israel Deaconess Medical Center, Georgia State University Research Foundation Inc.
    Inventors: John V. Frangioni, Hak Soo Choi, Maged M. Henary
  • Patent number: 10996170
    Abstract: Systems and methods for measuring short wave infrared fluorescence and autofluorescent signals are disclosed.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: May 4, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Moungi G. Bawendi, Oliver Thomas Bruns, Tulio A. Valdez, Jessica Ann Carr, Daniel Franke, Marianne Aellen
  • Patent number: 10987388
    Abstract: Provided are engineered phages populations, which are homogeneous in length, as well as methods of making and methods of using such phages. Also provided are engineered chlorotoxin-phages as well as their methods of making and using. The disclosed homogeneous phage populations and chlorotoxin-phages may be used, for example, for treating and/or imaging tumors, such as central nervous system tumors.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: April 27, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Angela M. Belcher, Uyanga Tsedev, Fred Lam
  • Patent number: 10973933
    Abstract: Disclosed herein are nanoparticles for diagnosis or treatment of tumors. The nanoparticles include: (a) a core including a Prussian blue dye; and (b) a shell obtained by partially or completely coating a surface of the Prussian blue core with albumin, thereby diagnosing a tumor by a nuclear magnetic resonance imaging apparatus and a near-infrared fluorescence imaging apparatus and necrotizing a tumor by a combined photothermal-photodynamic effect.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: April 13, 2021
    Assignee: GWANGJU INSTITUTE OE SCIENCE AND TECHNOLOGY
    Inventors: Giyoong Tae, Abhishek Sahu, Jong Hyun Lee
  • Patent number: 10962540
    Abstract: The present disclosure provides methods, reagents, systems, and devices that target ? lactamase as a biomarker for the sensitive and specific detection of tuberculosis-complex bacteria. Specifically, the present disclosure relates to methods and compositions for the detection of specific ?-lactamase protein and nucleic acid sequences to indicate the presence of tuberculosis-complex bacteria.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: March 30, 2021
    Assignee: The Texas A&M University System
    Inventors: Jeffrey D. Cirillo, Michael T. Norman
  • Patent number: 10948415
    Abstract: Methods for determining surgical margins using an imaging device are described that use multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: March 16, 2021
    Assignee: LI-COR, INC.
    Inventor: Han-Wei Wang
  • Patent number: 10918741
    Abstract: A PSMA-specific imaging agent comprising a compound according to formula I: are described, wherein S1 is an organic spacer group having from 5 to 30 carbons, A is an amino acid forming a portion of a negatively charged peptide oligomer, n is from 3 to 6, S2 is an organic spacer group having from 5 to 15 carbons, and I is an imaging group, and pharmaceutically acceptable salts thereof. The PSMA-specific imaging agents can be used to image PSMA within a tissue region to guide the treatment of diseases such as prostate cancer.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: February 16, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Steve Shih-Lin Huang, Warren D. Heston, Xinning Wang
  • Patent number: 10913855
    Abstract: Quenchers of the related art do not have a quenching ability high enough to sufficiently inhibit the emission of fluorescence from fluorescence compounds. Therefore, the present invention aims to provide a quencher which can sufficiently quench the fluorescence from fluorescent compounds including xanthene-based dyes. The present invention relates to a quencher formed of a compound represented by the following general formula (1), and the like.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: February 9, 2021
    Assignee: FUJIFILM Wako Pure Chemical Corporation
    Inventors: Katsufumi Suzuki, Tetsuji Murase, Shigeaki Imazeki
  • Patent number: 10888531
    Abstract: The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: January 12, 2021
    Assignee: DSM IP ASSETS B.V.
    Inventors: George Mihov, Guy Draaisma, Silvana Rensina Antonnietta Di Silvestre, Tristan Handels
  • Patent number: 10883998
    Abstract: The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: January 5, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Geoffrey A. von Maltzahn, Gabriel A. Kwong
  • Patent number: 10829727
    Abstract: Described herein are a system, device, methods and compositions related to generating 3-dimensional cardiac tissues. Also described herein are a system, device, and methods of maturing 3-dimensional cardiac tissues and maintaining their viability in culture.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 10, 2020
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Christopher S. Chen, Rebeccah Luu, Anant Chopra
  • Patent number: 10813563
    Abstract: Fluorescence based tracking of a light-emitting marker in a bodily fluid stream is conducted by: providing a light-emitting marker into a fluid stream; establishing field of view monitoring by placement of a sensor, such as a high speed camera, at a region of interest; recording image data of light emitted by the marker at the region of interest; determining time characteristics of the light output of the marker traversing the field of view; and calculating flow characteristics based on the time characteristics. Furthermore generating a velocity vector map may be conducted using a cross correlation technique, leading and falling edge considerations, subtraction, and/or thresholding.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: October 27, 2020
    Assignee: SCINOVIA CORP.
    Inventors: James Bradley Sund, Sr., David S. Cohen
  • Patent number: 10792377
    Abstract: A compound, a method of imaging a cell, and a method of detecting a cancer, an inflammatory disease, or a neoplastic disease are provided. The compound includes a nitroxide derivative of a fluorophore that is activatable upon exposure to free radicals. The method of imaging a cell includes contacting the cell with an activatable nitroxide derivative of a fluorophore. The method of detecting a cancer, an inflammatory disease, or a neoplastic disease includes administering an activatable nitroxide derivative of a fluorophore and then imaging one or more cells contacted with the compound.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: October 6, 2020
    Assignee: Vanderbilt University
    Inventors: Jashim Uddin, Brenda C. Crews, Lawrence J. Marnett
  • Patent number: 10758631
    Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided. A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: September 1, 2020
    Assignee: LI-COR, INC.
    Inventors: Vassil Elitzin, William M. Volcheck, Katie Schaepe, Rahul Patil
  • Patent number: 10753941
    Abstract: The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: August 25, 2020
    Assignees: The Hong Kong University of Science and Technology, National University of Singapore
    Inventors: Benzhong Tang, Wei Qin, Jianzhao Liu, Sijie Chen, Tsz Kin Kwok, Bin Liu, Kai Li, Dan Ding, Haibin Shi, Jun Long Geng, Jingzhi Sun, Anjun Qin, Qiuli Zhao
  • Patent number: 10743770
    Abstract: A photoacoustic device comprises a light source configured to generate first and second lights; an irradiation unit configured to generate a first acoustic wave from an object including a contrast agent by irradiating the object with the first light, and then bleach the contrast agent by irradiating the object with the second light and generate a second acoustic wave from the object by irradiating the object with the first light after bleaching; a receiving unit configured to output a first signal upon receiving the first acoustic wave and output a second signal upon receiving the second acoustic wave; and an acquisition unit configured to acquire first information based on the first signal, and acquire second information based on the second signal.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: August 18, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Kengo Kanazaki, Tatsuki Fukui, Satoshi Yuasa
  • Patent number: 10712322
    Abstract: The present invention provides methods for analyzing compositions of polypeptides such as antibodies by ionic strength-mediated pH gradient ion exchange chromatography. In some aspects, the methods use a combination of pH gradients and ionic strength gradients to separate the polypeptide from charge variants of the polypeptide. In some aspects, the methods use a stable ionic strength to optimize the pH gradient separation window to separate the polypeptide from charge variants. Such methods are useful for analyzing polypeptide, e.g. antibodies, with a pI greater than 9 or a pI less than 7. In some aspects, the invention provides a multiproduct method for the analysis of polypeptides of varying pI's.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: July 14, 2020
    Assignee: Genentech, Inc.
    Inventors: Yajun Wang, George Tony Moreno, Boyan Zhang, Liangyi Zhang, Dell Farnan, Thomas Patapoff
  • Patent number: 10709391
    Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting probes associated with circulating cells of the tumor that travel to subsurface vasculature of the body. The probe enters a tumor and associates with cells of the tumor before the cells metastasize. A wearable body-mountable device can be worn for a protracted period of time to detect the probe associated with circulating tumor cells in the vasculature at low concentrations and/or at low rates. A body-mounted device could detect the presence of such released, tumor-cell-associated probes to determine a presence or status of a tumor in the body.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: July 14, 2020
    Assignee: Verily Life Sciences LLC
    Inventors: Alberto Clemente Vitari, Andrew Homyk, Joshua Simon Klein, Marija Pavlovic, Jerrod Joseph Schwartz
  • Patent number: 10697950
    Abstract: Disclosed herein is a fluorescent compound represented by the following general formula and having fluorescence characteristics that vary in the presence of a subject substance, wherein R1 and R2 each independently represent a carboxyl group, or a substituent containing a carboxyl group, and R3 and R4 each independently represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxyl group, a carboxyl group, or a substituent containing a carboxyl group.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: June 30, 2020
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA TEC KABUSHIKI KAISHA
    Inventors: Hiroki Iwanaga, Ryozo Akiyama
  • Patent number: 10676840
    Abstract: The method is a method of evaluating a manufacturing process of a silicon material, wherein the manufacturing process includes a process that uses a member containing a carbon-containing sintered body, and the method of evaluating the manufacturing process of a silicon material includes performing DLTS measurement on a silicon material manufactured in the manufacturing process, and estimating a heavy metal contamination source of a silicon material manufactured in the manufacturing process with an indicator in the form of presence/absence of detection of a peak of a carbon-related level and presence/absence of detection of a peak of a heavy metal-related level in a DLTS spectrum obtained by the DLTS measurement.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: June 9, 2020
    Assignee: SUMCO CORPORATION
    Inventors: Noritomo Mitsugi, Kazutaka Eriguchi, Shuichi Samata, Ayumi Masada
  • Patent number: 10675242
    Abstract: The object of the invention is to elevate the stability of an aqueous formulation comprising ALAs and an iron compound. The present invention provides an aqueous formulation comprising ALAs and an iron compound, characterized in that it further comprises 0.2-30% by weight of salts, said salts are sodium salts or potassium salts, and the pH of said aqueous formulation is 2-8.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: June 9, 2020
    Assignee: SBI PHARMACEUTICALS, CO., LTD.
    Inventors: Mika Morishita, Urara Ota, Masahiro Ishizuka
  • Patent number: 10656092
    Abstract: A method of quantifying a specific biological material in a specimen stained using fluorescent dye accumulating particles capable of binding to the material includes: inputting a first fluorescence image obtained by capturing an image of the specimen; extracting a certain region from the first fluorescence image and calculating a first luminance integrated value by integrating luminance values of the certain region; and calculating the number of the particles included in the certain region from the first luminance integrated value and an average luminance value per fluorescent dye accumulating particle, wherein the average luminance value is calculated from a distribution of second luminance integrated values obtained by integrating luminance values for individual bright spot regions, which indicate emission of light by the fluorescent dye accumulating particles, in a second fluorescence image obtained by capturing an image of a preparation onto which the fluorescent dye accumulating particles are dispersed w
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: May 19, 2020
    Assignee: Konica Minolta, Inc.
    Inventors: Yuichi Ozaki, Kensaku Takanashi, Daisuke Tomioka
  • Patent number: 10646591
    Abstract: Disclosed are imaging agents having the following Formula I: wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide, Q is a fluorescence quencher molecule, and M is a moiety selected from the group consisting of PEG or derivative thereof and a targeting ligand, and wherein F, Q and M are linked to separate amino acids of the enzymatically cleavable oligopeptide. Compositions comprising such compounds, as well as methods of use, methods of identifying a cell or a population of cells in vivo expressing a protease of interest, and methods of treating a disease through imaging are also disclosed.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: May 12, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Xiaoyuan Chen, Seulki Lee, Lei Zhu
  • Patent number: 10563198
    Abstract: Antisense oligonucleotides capable of preventing or reducing exon 73 inclusion into the human COL7A mRNA are characterized in various ways: (a) the oligonucleotide's sequence includes at most two CpG sequences; (b) the oligonucleotide has a length of no more than 24 nucleotides; (c) the oligonucleotide is capable of annealing to the (SRp40/SC35 binding/ESE) element in exon73. These oligonucleotides can usefully be oligoribonucleotides with modified internucleosidic linkages e.g. phosphorothioate linkages.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 18, 2020
    Assignee: WINGS THERAPEUTICS, INC.
    Inventors: Elisabeth Marlene Haisma, Marko Potman, Wouter Beumer, Vera Brinks
  • Patent number: 10557854
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: February 11, 2020
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A Kularatne, Pravin Gagare, Ananda Kumar Kanduluru
  • Patent number: 10550388
    Abstract: Compositions and methods for treatment of glioma are disclosed. In particular, the invention relates to methods of treating glioma by inhibiting pleiotrophin signaling to limit high-grade glioma invasion.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: February 4, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michelle Monje-Deisseroth, Elizabeth Qin
  • Patent number: 10531803
    Abstract: The present invention provides a method of imaging blood vessels or blood flow in blood vessels in an animal comprising: (i) injecting a lipid solution into the bloodstream of the animal; (ii) imaging the blood vessels by an imaging method; and (iii) calculating the blood flow velocity in the blood vessels.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: January 14, 2020
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Yingtian Pan, Congwu Du, Hugang Ren, Nora Volkow
  • Patent number: 10532113
    Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: January 14, 2020
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ronit Satchi-Fainaro, Doron Shabat, Rachel Blau, Yana Epshtein, Hemda Baabur-Cohen, Shiran Ferber, Orit Redy-Keisar, Einat Kisin-Finfer
  • Patent number: 10520420
    Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: December 31, 2019
    Assignee: Essen Instruments, Inc.
    Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
  • Patent number: 10508127
    Abstract: The invention relates to a compound V for complexing metallic isotopes, comprising a chelator X and one or more targeting vectors conjugated with the chelator X, said targeting vectors having the structure -L1-R1-L2-R2-L3-R3, wherein R3 contains a bisphosphonate. A pharmaceutical consists of the compound V and a metallic isotope which is complexed with compound V.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 17, 2019
    Assignee: SCV GmbH
    Inventors: Frank Rösch, Marian Meckel
  • Patent number: 10493171
    Abstract: The present invention provides a laparoscopic surgery method comprising inspection of peritoneal surfaces under an isotonic solution comprising a contrast enhancing agent using near contact scanning by a laparoscope. Accordingly, the method according to the current invention comprises introducing the solution and the contrast enhancing agent into the retroperitoneal space through a catheter or a channel of a laparoscope using an irrigation pump. The present invention provides also an isotonic laparoscopy solution comprising a contrast enhancing agent enhancing the contrast of the laparoscopic view.
    Type: Grant
    Filed: January 10, 2016
    Date of Patent: December 3, 2019
    Inventor: Tamer Ahmet Seckin
  • Patent number: 10481068
    Abstract: The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: November 19, 2019
    Assignee: SLINGSHOT BIOSCIENCES
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Patent number: 10444214
    Abstract: Disclosed herein is a fluorescent compound represented by the following general formula and having fluorescence characteristics that vary in the presence of a subject substance, wherein R1 and R2 each independently represent a carboxyl group, or a substituent containing a carboxyl group, and R3 and R4 each independently represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxyl group, a carboxyl group, or a substituent containing a carboxyl group.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: October 15, 2019
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA TEC KABUSHIKI KAISHA
    Inventors: Hiroki Iwanaga, Ryozo Akiyama
  • Patent number: 10420471
    Abstract: A method is provided for deep tissue imaging using multi-photon excitation of a fluorescent agent. The fluorescent agent is irradiated with an ultrafast laser to produce an excited singlet state (Sn) which subsequently undergoes non-radiative relaxation to a first singlet state (S1). The S1 state undergoes fluorescence to the ground state S0 to produce an emission wavelength. Both the excitation and emission wavelengths are within the near infrared optical window, thereby permitting deep tissue penetration for both the incoming and outgoing signals.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: September 24, 2019
    Assignee: Research Foundation of the City University of New York
    Inventors: Robert R. Alfano, Yang Pu, Lingyan Shi, Sebastião Pratavieira
  • Patent number: 10406385
    Abstract: Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. Panthenol-citrate containing materials are a class of nontoxic, photoluminescent-chromophore-containing compounds, oligomers, and polymers with high absorption in the UVA and UVB range that can be incorporated and/or engineered into a variety of optically-active biomaterials (e.g., sunscreen products).
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: September 10, 2019
    Assignee: Northwestern University
    Inventors: Guillermo A. Ameer, Robert van Lith, Jian Yang
  • Patent number: 10376563
    Abstract: Methods and microorganisms for systemically introducing a polypeptide in the bloodstream of a subject. The methods of the invention include administering into the gastrointestinal tract of a subject a bacterium configured to express and produce and release the polypeptide. The bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject, preferably in a detectable amount. The microorganisms of the invention include lactic acid bacteria, such as Lactobacillus reuteri, that comprise a recombinant gene configured to express a polypeptide to be systemically introduced.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: August 13, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jan Peter Van Pijkeren, Alan Attie, Mark Keller, Jee-Hwan Oh
  • Patent number: 10335501
    Abstract: Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and/or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 2, 2019
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University
    Inventors: Michelle S. Bradbury, Barney Yoo, Ulrich Wiesner, Peiming Chen, Kai Ma, Snehal G. Patel, Daniella Karassawa Zanoni
  • Patent number: 10333045
    Abstract: A method for obtaining copper arsenic chalcogen derived nanoparticles, including selecting a first precursor material from the group comprising copper, arsenic, antimony, bismuth, and mixtures thereof, selecting a second material from the group comprising sulfur, selenium, tellurium, and mixtures thereof, and then reacting both precursors in a solvent medium at conditions conducive to the formation of copper arsenic chalcogen derived nanoparticles.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 25, 2019
    Assignee: Purdue Research Foundation
    Inventors: Rakesh Agrawal, Bryan William Boudouris, Robert B. Balow
  • Patent number: 10301720
    Abstract: This disclosure relates to a method for preparing a polymer thin film with water repellency and oil repellency, including: thermally decomposing a thermal initiator to form a radical; reacting the radical with a monomer mixture of a specific composition to synthesize a polymer; and depositing the synthesized polymer on a substrate, and a polymer thin film with water repellency and oil repellency including a polymer resin including (meth)acrylate-based repeat units substituted with a fluorine-containing functional group and repeat units derived from a compound including at least two reactive functional groups at a specific ratio.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: May 28, 2019
    Assignee: LG Chem, Ltd.
    Inventors: Eun Jeong Lee, Ki-Hwan Kim, Chan Hyoung Park
  • Patent number: 10271734
    Abstract: A photoacoustic apparatus comprises a light source; an irradiation unit configured to radiate light from the light source to an object that contains a contrast agent; a receiving unit configured to receive acoustic waves generated when the contrast agent absorbs the light radiated by the irradiation unit and output an electrical signal; a correction processing unit configured to correct a signal strength of the electrical signal, based on a temporal change in a concentration of the contrast agent contained in the object; and an acquiring unit configured to acquire characteristics information on the object, based on the electrical signal that has been corrected by the correction processing unit.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 30, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Tatsuki Fukui, Atsushi Takahashi, Satoshi Yuasa