Diagnostic Or Test Agent Produces In Vivo Fluorescence Patents (Class 424/9.6)
  • Patent number: 10444214
    Abstract: Disclosed herein is a fluorescent compound represented by the following general formula and having fluorescence characteristics that vary in the presence of a subject substance, wherein R1 and R2 each independently represent a carboxyl group, or a substituent containing a carboxyl group, and R3 and R4 each independently represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxyl group, a carboxyl group, or a substituent containing a carboxyl group.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: October 15, 2019
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA TEC KABUSHIKI KAISHA
    Inventors: Hiroki Iwanaga, Ryozo Akiyama
  • Patent number: 10420471
    Abstract: A method is provided for deep tissue imaging using multi-photon excitation of a fluorescent agent. The fluorescent agent is irradiated with an ultrafast laser to produce an excited singlet state (Sn) which subsequently undergoes non-radiative relaxation to a first singlet state (S1). The S1 state undergoes fluorescence to the ground state S0 to produce an emission wavelength. Both the excitation and emission wavelengths are within the near infrared optical window, thereby permitting deep tissue penetration for both the incoming and outgoing signals.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: September 24, 2019
    Assignee: Research Foundation of the City University of New York
    Inventors: Robert R. Alfano, Yang Pu, Lingyan Shi, Sebastião Pratavieira
  • Patent number: 10406385
    Abstract: Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. Panthenol-citrate containing materials are a class of nontoxic, photoluminescent-chromophore-containing compounds, oligomers, and polymers with high absorption in the UVA and UVB range that can be incorporated and/or engineered into a variety of optically-active biomaterials (e.g., sunscreen products).
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: September 10, 2019
    Assignee: Northwestern University
    Inventors: Guillermo A. Ameer, Robert van Lith, Jian Yang
  • Patent number: 10376563
    Abstract: Methods and microorganisms for systemically introducing a polypeptide in the bloodstream of a subject. The methods of the invention include administering into the gastrointestinal tract of a subject a bacterium configured to express and produce and release the polypeptide. The bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject, preferably in a detectable amount. The microorganisms of the invention include lactic acid bacteria, such as Lactobacillus reuteri, that comprise a recombinant gene configured to express a polypeptide to be systemically introduced.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: August 13, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jan Peter Van Pijkeren, Alan Attie, Mark Keller, Jee-Hwan Oh
  • Patent number: 10335501
    Abstract: Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and/or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 2, 2019
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University
    Inventors: Michelle S. Bradbury, Barney Yoo, Ulrich Wiesner, Peiming Chen, Kai Ma, Snehal G. Patel, Daniella Karassawa Zanoni
  • Patent number: 10333045
    Abstract: A method for obtaining copper arsenic chalcogen derived nanoparticles, including selecting a first precursor material from the group comprising copper, arsenic, antimony, bismuth, and mixtures thereof, selecting a second material from the group comprising sulfur, selenium, tellurium, and mixtures thereof, and then reacting both precursors in a solvent medium at conditions conducive to the formation of copper arsenic chalcogen derived nanoparticles.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 25, 2019
    Assignee: Purdue Research Foundation
    Inventors: Rakesh Agrawal, Bryan William Boudouris, Robert B. Balow
  • Patent number: 10301720
    Abstract: This disclosure relates to a method for preparing a polymer thin film with water repellency and oil repellency, including: thermally decomposing a thermal initiator to form a radical; reacting the radical with a monomer mixture of a specific composition to synthesize a polymer; and depositing the synthesized polymer on a substrate, and a polymer thin film with water repellency and oil repellency including a polymer resin including (meth)acrylate-based repeat units substituted with a fluorine-containing functional group and repeat units derived from a compound including at least two reactive functional groups at a specific ratio.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: May 28, 2019
    Assignee: LG Chem, Ltd.
    Inventors: Eun Jeong Lee, Ki-Hwan Kim, Chan Hyoung Park
  • Patent number: 10271734
    Abstract: A photoacoustic apparatus comprises a light source; an irradiation unit configured to radiate light from the light source to an object that contains a contrast agent; a receiving unit configured to receive acoustic waves generated when the contrast agent absorbs the light radiated by the irradiation unit and output an electrical signal; a correction processing unit configured to correct a signal strength of the electrical signal, based on a temporal change in a concentration of the contrast agent contained in the object; and an acquiring unit configured to acquire characteristics information on the object, based on the electrical signal that has been corrected by the correction processing unit.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 30, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Tatsuki Fukui, Atsushi Takahashi, Satoshi Yuasa
  • Patent number: 10258578
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: April 16, 2019
    Assignee: PENDANT BIOSCIENCES, INC.
    Inventors: Frantz Le Dévédec, Christine Jane Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
  • Patent number: 10251897
    Abstract: The present invention provides a therapeutic drug for diabetes containing 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine (DOPE) as an active ingredient, particularly a therapeutic drug for diabetes that exhibits a GLUT4 endocytosis suppressive action by suppressing activation of PKC? and the like.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: April 9, 2019
    Assignee: NISHIZAKI BIOINFORMATION RESEARCH INSTITUTE
    Inventor: Tomoyuki Nishizaki
  • Patent number: 10238756
    Abstract: The present invention relates to lipid-associated indocyanine green particles for enhanced functional high-resolution near-infrared fluorescence medical imaging of lymphatic vessels, lymph nodes, lymphatic abnormalities, tumors, and inflammation.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: March 26, 2019
    Assignee: Tongli Biomedical Co., Ltd.
    Inventors: Rodney J. Y. Ho, John C. Kraft, II, Mingxin Qian
  • Patent number: 10238683
    Abstract: A method for promoting entry of an agent (introduced agent) into a cell, the method comprising the step of complexing the introduced agent in the presence of an entry-promoting agent and then exposing to cells, wherein the entry-promoting agent comprises a linear and/or branched or cyclic polymonoguanide/polyguanidine, polybiguanide, analogue or derivative thereof according to the following Formula 1a & b. The method also provides a means for formation of nanoparticles formed between the entry promoting agent and the introduced agent.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: March 26, 2019
    Assignee: THE ROYAL VETERINARY COLLEGE
    Inventors: Liam Good, Kantaraja Chindera, Valentina Gburcik
  • Patent number: 10239919
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: March 26, 2019
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Patent number: 10202422
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: February 12, 2019
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Patent number: 10194854
    Abstract: A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flrmeas signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DRexmeas DRem, and DRem,filtered signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flrmeas signal within the post-equilibration portion of the measurement data set to an IFagent signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 5, 2019
    Assignee: MediBeacon Inc.
    Inventors: Jennifer Keating, Kimberly Shultz, Kate Bechtel, Edward Solomon
  • Patent number: 10188297
    Abstract: A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, an applicator for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: January 29, 2019
    Assignee: Case Western Reserve University
    Inventor: James Basilion
  • Patent number: 10184878
    Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: January 22, 2019
    Assignee: IntelliCyt Corporation
    Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
  • Patent number: 10175239
    Abstract: The present disclosure provides methods, reagents, systems, and devices that target ? lactamase as a biomarker for the sensitive and specific detection of tuberculosis-complex bacteria. Specifically, the present disclosure relates to methods and compositions for the detection of specific ?-lactamase protein and nucleic acid sequences to indicate the presence of tuberculosis-complex bacteria.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: January 8, 2019
    Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Jeffrey D. Cirillo, Michael T. Norman
  • Patent number: 10159738
    Abstract: The present invention concerns metal-organic hybrid solids having a modified outer surface. These solids can be used, for example, for the storage and vectoring of molecules of interest such as pharmaceutically active ingredients, compounds of interest in cosmetics and markers, for example contrast agents. These solids have good results in terms of active drug loading capacities, biocompatibility, stability and controlling the release of the active ingredients encapsulated.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: December 25, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE VERSAILLES-SAINT QUENTIN EN YVELINES, UNIVERSITE PARIS-SUD
    Inventors: Ruxandra Gref, Valentina Agostoni, Samia Daoud-Mahammed, Violeta Rodriguez-Ruiz, Milo Malanga, Laszlo Jicsinszky, Patricia Horcajada-Cortes, Christian Serre
  • Patent number: 10117954
    Abstract: This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: November 6, 2018
    Assignee: The General Hospital Corporation
    Inventors: Thomas Reiner, Edmund J. Keliher, Ralph Weissleder
  • Patent number: 10105455
    Abstract: Disclosed are compositions that comprise a cyclooxygenase-2-selective therapeutic and/or diagnostic agent having a therapeutic and/or diagnostic agent conjugated to a NSAID drug; and a ROS-responsive nanoparticle. Methods of making and using these compositions for drug encapsulation and delivery are also disclosed.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: October 23, 2018
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Lawrence J. Marnett, Jashim Uddin, Thomas A. Werfel, Mukesh Gupta, Brenda C. Crews
  • Patent number: 10076509
    Abstract: Methods and compositions regarding nested nanoparticles comprising polymer nanoparticles encased in a cyclodextrin shell to facilitate sequence-specific drug release.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: September 18, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Elvin Blanco
  • Patent number: 10071084
    Abstract: A nanoparticle including a hydrophobic active ingredient and a polypeptide, as well as a liposome including the nanoparticle and methods of making and using the nanoparticle.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: September 11, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Don-wook Lee, Jung-yong Nam, Hyun-ryoung Kim, Eun-sung Park
  • Patent number: 10060929
    Abstract: A novel imaging reagent and gel-based method for analyzing and comparing phosphoproteomes on the same gel are disclosed herein.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: August 28, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Weiguo Andy Tao, Linna Wang
  • Patent number: 10060854
    Abstract: A non-invasive device for determining the fertility and/or sex of an egg. This device obtains a spectral response, specific to the shell, to an incident light signal. The device has a focusing element configured to focus the incident light signal on a surface portion and/or an internal portion of at least one layer of the shell, and elements for determining the fertility and/or sex of the egg as a function of the spectral response specific to the shell.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: August 28, 2018
    Assignee: TRONICO
    Inventor: Marc Schortgen
  • Patent number: 10053447
    Abstract: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: August 21, 2018
    Assignees: Pierce Biotechnology, Inc, Dyomics GmbH
    Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann
  • Patent number: 10046068
    Abstract: This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 14, 2018
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael J. Rishel
  • Patent number: 9999687
    Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: June 19, 2018
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Kevin Groves, Dorin V. Preda
  • Patent number: 9974870
    Abstract: The present invention encompasses compositions comprising two spectrally distinct radionuclides separated by a site susceptible to cleavage. Compositions of the invention may be used to detect enzyme activity and/or image diseases associated with said enzyme activity.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: May 22, 2018
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Samuel Achilefu, Kvar Black
  • Patent number: 9968403
    Abstract: An optical device including an optical fiber having a longitudinal axis and an optical fiber core with a distal end having a distal terminating end configured to discharge a first laser energy in a first direction and a second laser energy in a second direction. The optical device also includes a fiber cap having an interior cavity and an opening to the interior cavity, where the distal end of the optical fiber core is received within the interior cavity through the opening. A cladding is included on the distal end of the optical fiber core between the optical fiber core and the fiber cap.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: May 15, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Thomas Charles Hasenberg, Steven Yihlih Peng, Brian P. Watschke, Douglas L. Evans, Guangjian Wang, Rongwei Jason Xuan, Wen-Jui Ray Chia
  • Patent number: 9952133
    Abstract: A particle analyzer, comprising a source of a beam of pulsed optical energy; a detector comprising a number of spectral detection channels to detect optical signals resulting from interactions between the beam and particles in a sample (such as, e.g., fluorescence signals), and to convert the optical signals into respective electrical signals; optical paths from the source to the sample and from the sample to the detector; a flowcell connected with the optical paths and with a flow path for a suspension of particles; a signal processing module capable of: receiving the electrical signals from the detector; mathematically combining individual decay curves in the signals into a decay supercurve; allocating individual components of the supercurve to discrete bins of predetermined time constants; and quantifying the relative contribution of individual components to the supercurve; a particle sorting actuator; an actuator driver; and at least one particle collection receptacle.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: April 24, 2018
    Assignee: Kinetic River Corp.
    Inventor: Giacomo Vacca
  • Patent number: 9944683
    Abstract: Chlorotoxin variants, chlorotoxin variant conjugates, compositions that include the chlorotoxin variants or conjugates, and methods for using the chlorotoxin variants, conjugates, and compositions.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: April 17, 2018
    Assignee: Fred Hutchinson Cancer Research Center
    Inventor: James M. Olson
  • Patent number: 9945865
    Abstract: Disclosed herein is a composition comprising a crosslinked hydrogel; where the hydrogel comprises a polymer having a cleavable bond along a backbone of the polymer, along a substituent that undergoes crosslinking, or along the backbone of the polymer and along the substituent that undergoes crosslinking; where the cleavable bond is operative to be cleaved by an enzyme released in the body of a living being; and a semiconducting quantum dot that emits light in the visible portion of the electromagnetic spectrum.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: April 17, 2018
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventor: Jennifer Andrew
  • Patent number: 9932365
    Abstract: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting an N-terminally labeled protein.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: April 3, 2018
    Assignee: PROMEGA CORPORATION
    Inventors: Jessica Kelts, Poncho Meisenheimer, John Shultz
  • Patent number: 9920020
    Abstract: Squaraine dyes are used to detect the presence of protein in a test sample, which is a substance that may contain protein. A squarine dye is placed in water, and in some instances joined with an aggregation agent, to create an aqueous dye solution. That dye solution is joined with a test sample. When the dye solution is joined with the test sample and the resultant test solution is excited by the application of photons, a resulting fluorescence or absence thereof reveals if protein was present in the test sample.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: March 20, 2018
    Assignee: The University of Akron
    Inventors: Yi Pang, Yongqian Xu
  • Patent number: 9903803
    Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: February 27, 2018
    Assignee: Intellicyt Corporation
    Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
  • Patent number: 9846167
    Abstract: Methods for identifying subjects having bone loss by detecting bone microparticles in a sample of their bodily fluid are disclosed. Methods for monitoring bone loss and assessing efficacy of bone loss therapies by detecting bone microparticles in bodily fluid samples are also disclosed. Compounds for use as a negative control in the disclosed methods are provided as well as kits comprising such compounds.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: December 19, 2017
    Assignee: Lawson Health Research Institute
    Inventors: Hon Sing Leong, Leonard Luyt, Colleen Nicole Biggs, Andre St. Amant, John D. Lewis, Leonard Minuk
  • Patent number: 9839378
    Abstract: Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: December 12, 2017
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: David R. Markle, Ritchie A. Wessling, Donald J. Kolehmainen
  • Patent number: 9815871
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: November 14, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Peter Quoc Nguyen, Zsofia Magarian
  • Patent number: 9772286
    Abstract: It is to provide a method for detecting urothelial cancer simply and with high accuracy. It is a method for detecting urothelial cancer comprising administering 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these to a test subject, collecting urine from the test subject, and detecting the presence of fluorescence or amount of fluorescence in the collected urine.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: September 26, 2017
    Assignees: SBI Pharmaceuticals Co., Ltd., National University Corporation Kochi University
    Inventors: Keiji Inoue, Taro Shuin, Mutsuo Furihata, Yoshihiko Hirao, Tohru Tanaka
  • Patent number: 9738605
    Abstract: Hybrid compounds of curcumin and melatonin as neuroprotectants are provided. The hybrid compounds are useful for the treatment and/or prevention of Alzheimer's disease (AD), as well as other neurodegenerative diseases. The hybrid compounds exhibited superior and potent neuroprotection in an AD model.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: August 22, 2017
    Assignee: Virginia Commonwealth University
    Inventor: Shijun Zhang
  • Patent number: 9724416
    Abstract: The present invention relates to a composition for improving or promoting hair growth, which contains, as an active ingredient, a photosensitizer-peptide conjugate, and to a method for screening for the hair growth promoter using the active ingredients. ALA, which is the photosensitizer of the present invention, is preferably activated by LED radiation, and more preferably activated by radiation having a long wavelength of 650 to 675 nm. The peptide of the present invention is a peptide in which 3 to 7 amino acid residues are incorporated (most preferably, glycine-histidine-lysine), and may cooperate with the photosensitizer to enable very superior hair growth improving or promoting effects using light radiation. Further, the composition of the present invention may exhibit further superior effects when natural extracts (for example, Cimicifuga heracleifolia extracts, Scutellaria baicalensis extracts or Codonopsis lanceolata extracts) are added.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: August 8, 2017
    Assignee: UNIQUE MEDICARE CO., LTD.
    Inventors: Darren Williams, Da-Woon Jung, Soon-Ho Yim
  • Patent number: 9700638
    Abstract: The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: July 11, 2017
    Assignees: Rutgers, The State University of New Jersey, New Jersey Institute of Technology
    Inventors: Arkady Mustaev, David S. Perlin, Laura Wirpsza
  • Patent number: 9676996
    Abstract: A method of synthesizing a hybrid nanomaterial substrate for use in a light emitting structure is provided comprising the steps of: (a) defining one or more light emission characteristics for the light emitting structure; (b) selecting a nanocrystal and a compatible light emitting molecule; and (c) based on the light emission characteristics synthesizing a hybrid nanomaterial substrate by selectively varying the size of the nanocrystals in the substrate, and selectively bonding the light emitting molecules to surfaces of the nanocrystals, thereby synthesizing a nanomaterial structure that is operable to define a single illuminating entity operable upon application of a single excitation energy value to generate light emissions consistent with the light emission characteristics.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: June 13, 2017
    Inventors: Pavle Radovanovic, Ting Wang
  • Patent number: 9662080
    Abstract: A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an X-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and X-ray images of the subject irradiated by the X-ray source.
    Type: Grant
    Filed: August 31, 2013
    Date of Patent: May 30, 2017
    Assignee: ACADEMIA SINICA
    Inventors: Yeu-Kuang Hwu, Chia-Chi Chien, Cheng-Liang Wang
  • Patent number: 9655866
    Abstract: Disclosed is a cleansing composition comprising: (i) a non-soap surfactant which is an alkyi glycinate, alkyi carboxy glycinate, sarcosinate, glutamate or a mixture thereof; and, (ii) one or more antimicrobial agent, wherein pH of said composition is at least 8.5 and zein number of said composition is in the range of 10 to 65 and wherein soap content of said composition is not greater than 5 wt %. The formulation is highly alkaline, yet gives mild antibacterial cleansing action.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: May 23, 2017
    Assignee: Conopco, Inc.
    Inventors: Shashank Narendra Gupta, Nitish Kumar, Gagarin Wamanrao Raikar, Rajan Raghavachari, Vibhav Ramrao Sanzgiri
  • Patent number: 9649392
    Abstract: There is provided a central nervous system labelling composition for intranasal administration for the purpose of labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration. Additionally, there is provided a method of non-invasively labelling the central nervous system by way of an administration route that entails little transferability to the entire body. Furthermore, there is provided a screening method using a central nervous system labelling composition for intranasal administration.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: May 16, 2017
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Tsuyoshi Nomoto, Kohei Watanabe, Taichi Shintou, Takeshi Miyazaki, Toshio Tanaka, Yuhei Nishimura, Yasuhito Shimada
  • Patent number: 9597416
    Abstract: The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: March 21, 2017
    Assignee: PHANOS TECHNOLOGIES, INC.
    Inventor: Brian D. Gray
  • Patent number: 9587071
    Abstract: The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: March 7, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, IMRA OF AMERICA, INC.
    Inventors: Duxin Sun, Hongwei Chen, Wei Qian, Yong Che, Masayuki Ito, Hayley Paholak, Kanokwan Sansanaphongpricha
  • Patent number: 9439982
    Abstract: The invention relates to fluorescent derivatives of cyanines conjugated with a polyamine group, having formula (I), or a pharmaceutically acceptable salt thereof. The invention also relates to the method for preparing said derivatives, diagnostic compositions containing same and the use thereof as a diagnostic probe for the detection of cancer tumors, in particular in vivo.
    Type: Grant
    Filed: November 24, 2011
    Date of Patent: September 13, 2016
    Assignees: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yves Guminski, Thierry Imbert, Sabrina Pesnel, Arnaud Pillon, Alain Le Pape, Stephanie Lerondel