Diagnostic Or Test Agent Produces In Vivo Fluorescence Patents (Class 424/9.6)
  • Patent number: 10829727
    Abstract: Described herein are a system, device, methods and compositions related to generating 3-dimensional cardiac tissues. Also described herein are a system, device, and methods of maturing 3-dimensional cardiac tissues and maintaining their viability in culture.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 10, 2020
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Christopher S. Chen, Rebeccah Luu, Anant Chopra
  • Patent number: 10813563
    Abstract: Fluorescence based tracking of a light-emitting marker in a bodily fluid stream is conducted by: providing a light-emitting marker into a fluid stream; establishing field of view monitoring by placement of a sensor, such as a high speed camera, at a region of interest; recording image data of light emitted by the marker at the region of interest; determining time characteristics of the light output of the marker traversing the field of view; and calculating flow characteristics based on the time characteristics. Furthermore generating a velocity vector map may be conducted using a cross correlation technique, leading and falling edge considerations, subtraction, and/or thresholding.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: October 27, 2020
    Assignee: SCINOVIA CORP.
    Inventors: James Bradley Sund, Sr., David S. Cohen
  • Patent number: 10792377
    Abstract: A compound, a method of imaging a cell, and a method of detecting a cancer, an inflammatory disease, or a neoplastic disease are provided. The compound includes a nitroxide derivative of a fluorophore that is activatable upon exposure to free radicals. The method of imaging a cell includes contacting the cell with an activatable nitroxide derivative of a fluorophore. The method of detecting a cancer, an inflammatory disease, or a neoplastic disease includes administering an activatable nitroxide derivative of a fluorophore and then imaging one or more cells contacted with the compound.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: October 6, 2020
    Assignee: Vanderbilt University
    Inventors: Jashim Uddin, Brenda C. Crews, Lawrence J. Marnett
  • Patent number: 10758631
    Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided. A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: September 1, 2020
    Assignee: LI-COR, INC.
    Inventors: Vassil Elitzin, William M. Volcheck, Katie Schaepe, Rahul Patil
  • Patent number: 10753941
    Abstract: The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
    Type: Grant
    Filed: September 3, 2012
    Date of Patent: August 25, 2020
    Assignees: The Hong Kong University of Science and Technology, National University of Singapore
    Inventors: Benzhong Tang, Wei Qin, Jianzhao Liu, Sijie Chen, Tsz Kin Kwok, Bin Liu, Kai Li, Dan Ding, Haibin Shi, Jun Long Geng, Jingzhi Sun, Anjun Qin, Qiuli Zhao
  • Patent number: 10743770
    Abstract: A photoacoustic device comprises a light source configured to generate first and second lights; an irradiation unit configured to generate a first acoustic wave from an object including a contrast agent by irradiating the object with the first light, and then bleach the contrast agent by irradiating the object with the second light and generate a second acoustic wave from the object by irradiating the object with the first light after bleaching; a receiving unit configured to output a first signal upon receiving the first acoustic wave and output a second signal upon receiving the second acoustic wave; and an acquisition unit configured to acquire first information based on the first signal, and acquire second information based on the second signal.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: August 18, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Kengo Kanazaki, Tatsuki Fukui, Satoshi Yuasa
  • Patent number: 10709391
    Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting probes associated with circulating cells of the tumor that travel to subsurface vasculature of the body. The probe enters a tumor and associates with cells of the tumor before the cells metastasize. A wearable body-mountable device can be worn for a protracted period of time to detect the probe associated with circulating tumor cells in the vasculature at low concentrations and/or at low rates. A body-mounted device could detect the presence of such released, tumor-cell-associated probes to determine a presence or status of a tumor in the body.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: July 14, 2020
    Assignee: Verily Life Sciences LLC
    Inventors: Alberto Clemente Vitari, Andrew Homyk, Joshua Simon Klein, Marija Pavlovic, Jerrod Joseph Schwartz
  • Patent number: 10712322
    Abstract: The present invention provides methods for analyzing compositions of polypeptides such as antibodies by ionic strength-mediated pH gradient ion exchange chromatography. In some aspects, the methods use a combination of pH gradients and ionic strength gradients to separate the polypeptide from charge variants of the polypeptide. In some aspects, the methods use a stable ionic strength to optimize the pH gradient separation window to separate the polypeptide from charge variants. Such methods are useful for analyzing polypeptide, e.g. antibodies, with a pI greater than 9 or a pI less than 7. In some aspects, the invention provides a multiproduct method for the analysis of polypeptides of varying pI's.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: July 14, 2020
    Assignee: Genentech, Inc.
    Inventors: Yajun Wang, George Tony Moreno, Boyan Zhang, Liangyi Zhang, Dell Farnan, Thomas Patapoff
  • Patent number: 10697950
    Abstract: Disclosed herein is a fluorescent compound represented by the following general formula and having fluorescence characteristics that vary in the presence of a subject substance, wherein R1 and R2 each independently represent a carboxyl group, or a substituent containing a carboxyl group, and R3 and R4 each independently represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxyl group, a carboxyl group, or a substituent containing a carboxyl group.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: June 30, 2020
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA TEC KABUSHIKI KAISHA
    Inventors: Hiroki Iwanaga, Ryozo Akiyama
  • Patent number: 10675242
    Abstract: The object of the invention is to elevate the stability of an aqueous formulation comprising ALAs and an iron compound. The present invention provides an aqueous formulation comprising ALAs and an iron compound, characterized in that it further comprises 0.2-30% by weight of salts, said salts are sodium salts or potassium salts, and the pH of said aqueous formulation is 2-8.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: June 9, 2020
    Assignee: SBI PHARMACEUTICALS, CO., LTD.
    Inventors: Mika Morishita, Urara Ota, Masahiro Ishizuka
  • Patent number: 10676840
    Abstract: The method is a method of evaluating a manufacturing process of a silicon material, wherein the manufacturing process includes a process that uses a member containing a carbon-containing sintered body, and the method of evaluating the manufacturing process of a silicon material includes performing DLTS measurement on a silicon material manufactured in the manufacturing process, and estimating a heavy metal contamination source of a silicon material manufactured in the manufacturing process with an indicator in the form of presence/absence of detection of a peak of a carbon-related level and presence/absence of detection of a peak of a heavy metal-related level in a DLTS spectrum obtained by the DLTS measurement.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: June 9, 2020
    Assignee: SUMCO CORPORATION
    Inventors: Noritomo Mitsugi, Kazutaka Eriguchi, Shuichi Samata, Ayumi Masada
  • Patent number: 10656092
    Abstract: A method of quantifying a specific biological material in a specimen stained using fluorescent dye accumulating particles capable of binding to the material includes: inputting a first fluorescence image obtained by capturing an image of the specimen; extracting a certain region from the first fluorescence image and calculating a first luminance integrated value by integrating luminance values of the certain region; and calculating the number of the particles included in the certain region from the first luminance integrated value and an average luminance value per fluorescent dye accumulating particle, wherein the average luminance value is calculated from a distribution of second luminance integrated values obtained by integrating luminance values for individual bright spot regions, which indicate emission of light by the fluorescent dye accumulating particles, in a second fluorescence image obtained by capturing an image of a preparation onto which the fluorescent dye accumulating particles are dispersed w
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: May 19, 2020
    Assignee: Konica Minolta, Inc.
    Inventors: Yuichi Ozaki, Kensaku Takanashi, Daisuke Tomioka
  • Patent number: 10646591
    Abstract: Disclosed are imaging agents having the following Formula I: wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide, Q is a fluorescence quencher molecule, and M is a moiety selected from the group consisting of PEG or derivative thereof and a targeting ligand, and wherein F, Q and M are linked to separate amino acids of the enzymatically cleavable oligopeptide. Compositions comprising such compounds, as well as methods of use, methods of identifying a cell or a population of cells in vivo expressing a protease of interest, and methods of treating a disease through imaging are also disclosed.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: May 12, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Xiaoyuan Chen, Seulki Lee, Lei Zhu
  • Patent number: 10563198
    Abstract: Antisense oligonucleotides capable of preventing or reducing exon 73 inclusion into the human COL7A mRNA are characterized in various ways: (a) the oligonucleotide's sequence includes at most two CpG sequences; (b) the oligonucleotide has a length of no more than 24 nucleotides; (c) the oligonucleotide is capable of annealing to the (SRp40/SC35 binding/ESE) element in exon73. These oligonucleotides can usefully be oligoribonucleotides with modified internucleosidic linkages e.g. phosphorothioate linkages.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 18, 2020
    Assignee: WINGS THERAPEUTICS, INC.
    Inventors: Elisabeth Marlene Haisma, Marko Potman, Wouter Beumer, Vera Brinks
  • Patent number: 10557854
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: February 11, 2020
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A Kularatne, Pravin Gagare, Ananda Kumar Kanduluru
  • Patent number: 10550388
    Abstract: Compositions and methods for treatment of glioma are disclosed. In particular, the invention relates to methods of treating glioma by inhibiting pleiotrophin signaling to limit high-grade glioma invasion.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: February 4, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michelle Monje-Deisseroth, Elizabeth Qin
  • Patent number: 10531803
    Abstract: The present invention provides a method of imaging blood vessels or blood flow in blood vessels in an animal comprising: (i) injecting a lipid solution into the bloodstream of the animal; (ii) imaging the blood vessels by an imaging method; and (iii) calculating the blood flow velocity in the blood vessels.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: January 14, 2020
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Yingtian Pan, Congwu Du, Hugang Ren, Nora Volkow
  • Patent number: 10532113
    Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: January 14, 2020
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ronit Satchi-Fainaro, Doron Shabat, Rachel Blau, Yana Epshtein, Hemda Baabur-Cohen, Shiran Ferber, Orit Redy-Keisar, Einat Kisin-Finfer
  • Patent number: 10520420
    Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: December 31, 2019
    Assignee: Essen Instruments, Inc.
    Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
  • Patent number: 10508127
    Abstract: The invention relates to a compound V for complexing metallic isotopes, comprising a chelator X and one or more targeting vectors conjugated with the chelator X, said targeting vectors having the structure -L1-R1-L2-R2-L3-R3, wherein R3 contains a bisphosphonate. A pharmaceutical consists of the compound V and a metallic isotope which is complexed with compound V.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 17, 2019
    Assignee: SCV GmbH
    Inventors: Frank Rösch, Marian Meckel
  • Patent number: 10493171
    Abstract: The present invention provides a laparoscopic surgery method comprising inspection of peritoneal surfaces under an isotonic solution comprising a contrast enhancing agent using near contact scanning by a laparoscope. Accordingly, the method according to the current invention comprises introducing the solution and the contrast enhancing agent into the retroperitoneal space through a catheter or a channel of a laparoscope using an irrigation pump. The present invention provides also an isotonic laparoscopy solution comprising a contrast enhancing agent enhancing the contrast of the laparoscopic view.
    Type: Grant
    Filed: January 10, 2016
    Date of Patent: December 3, 2019
    Inventor: Tamer Ahmet Seckin
  • Patent number: 10481068
    Abstract: The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: November 19, 2019
    Assignee: SLINGSHOT BIOSCIENCES
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Patent number: 10444214
    Abstract: Disclosed herein is a fluorescent compound represented by the following general formula and having fluorescence characteristics that vary in the presence of a subject substance, wherein R1 and R2 each independently represent a carboxyl group, or a substituent containing a carboxyl group, and R3 and R4 each independently represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxyl group, a carboxyl group, or a substituent containing a carboxyl group.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: October 15, 2019
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA TEC KABUSHIKI KAISHA
    Inventors: Hiroki Iwanaga, Ryozo Akiyama
  • Patent number: 10420471
    Abstract: A method is provided for deep tissue imaging using multi-photon excitation of a fluorescent agent. The fluorescent agent is irradiated with an ultrafast laser to produce an excited singlet state (Sn) which subsequently undergoes non-radiative relaxation to a first singlet state (S1). The S1 state undergoes fluorescence to the ground state S0 to produce an emission wavelength. Both the excitation and emission wavelengths are within the near infrared optical window, thereby permitting deep tissue penetration for both the incoming and outgoing signals.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: September 24, 2019
    Assignee: Research Foundation of the City University of New York
    Inventors: Robert R. Alfano, Yang Pu, Lingyan Shi, Sebastião Pratavieira
  • Patent number: 10406385
    Abstract: Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. Panthenol-citrate containing materials are a class of nontoxic, photoluminescent-chromophore-containing compounds, oligomers, and polymers with high absorption in the UVA and UVB range that can be incorporated and/or engineered into a variety of optically-active biomaterials (e.g., sunscreen products).
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: September 10, 2019
    Assignee: Northwestern University
    Inventors: Guillermo A. Ameer, Robert van Lith, Jian Yang
  • Patent number: 10376563
    Abstract: Methods and microorganisms for systemically introducing a polypeptide in the bloodstream of a subject. The methods of the invention include administering into the gastrointestinal tract of a subject a bacterium configured to express and produce and release the polypeptide. The bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject, preferably in a detectable amount. The microorganisms of the invention include lactic acid bacteria, such as Lactobacillus reuteri, that comprise a recombinant gene configured to express a polypeptide to be systemically introduced.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: August 13, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jan Peter Van Pijkeren, Alan Attie, Mark Keller, Jee-Hwan Oh
  • Patent number: 10335501
    Abstract: Described herein are cyclic peptides, nanoparticles bound with cyclic peptides, and methods for using said cyclic peptides and/or said nanoparticles bound with cyclic peptides for intraoperative nerve tissue imaging.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 2, 2019
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University
    Inventors: Michelle S. Bradbury, Barney Yoo, Ulrich Wiesner, Peiming Chen, Kai Ma, Snehal G. Patel, Daniella Karassawa Zanoni
  • Patent number: 10333045
    Abstract: A method for obtaining copper arsenic chalcogen derived nanoparticles, including selecting a first precursor material from the group comprising copper, arsenic, antimony, bismuth, and mixtures thereof, selecting a second material from the group comprising sulfur, selenium, tellurium, and mixtures thereof, and then reacting both precursors in a solvent medium at conditions conducive to the formation of copper arsenic chalcogen derived nanoparticles.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 25, 2019
    Assignee: Purdue Research Foundation
    Inventors: Rakesh Agrawal, Bryan William Boudouris, Robert B. Balow
  • Patent number: 10301720
    Abstract: This disclosure relates to a method for preparing a polymer thin film with water repellency and oil repellency, including: thermally decomposing a thermal initiator to form a radical; reacting the radical with a monomer mixture of a specific composition to synthesize a polymer; and depositing the synthesized polymer on a substrate, and a polymer thin film with water repellency and oil repellency including a polymer resin including (meth)acrylate-based repeat units substituted with a fluorine-containing functional group and repeat units derived from a compound including at least two reactive functional groups at a specific ratio.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: May 28, 2019
    Assignee: LG Chem, Ltd.
    Inventors: Eun Jeong Lee, Ki-Hwan Kim, Chan Hyoung Park
  • Patent number: 10271734
    Abstract: A photoacoustic apparatus comprises a light source; an irradiation unit configured to radiate light from the light source to an object that contains a contrast agent; a receiving unit configured to receive acoustic waves generated when the contrast agent absorbs the light radiated by the irradiation unit and output an electrical signal; a correction processing unit configured to correct a signal strength of the electrical signal, based on a temporal change in a concentration of the contrast agent contained in the object; and an acquiring unit configured to acquire characteristics information on the object, based on the electrical signal that has been corrected by the correction processing unit.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: April 30, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Tatsuki Fukui, Atsushi Takahashi, Satoshi Yuasa
  • Patent number: 10258578
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: April 16, 2019
    Assignee: PENDANT BIOSCIENCES, INC.
    Inventors: Frantz Le Dévédec, Christine Jane Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
  • Patent number: 10251897
    Abstract: The present invention provides a therapeutic drug for diabetes containing 1,2-dioleoyl-sn-glycerol-3-phosphoethanolamine (DOPE) as an active ingredient, particularly a therapeutic drug for diabetes that exhibits a GLUT4 endocytosis suppressive action by suppressing activation of PKC? and the like.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: April 9, 2019
    Assignee: NISHIZAKI BIOINFORMATION RESEARCH INSTITUTE
    Inventor: Tomoyuki Nishizaki
  • Patent number: 10238756
    Abstract: The present invention relates to lipid-associated indocyanine green particles for enhanced functional high-resolution near-infrared fluorescence medical imaging of lymphatic vessels, lymph nodes, lymphatic abnormalities, tumors, and inflammation.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: March 26, 2019
    Assignee: Tongli Biomedical Co., Ltd.
    Inventors: Rodney J. Y. Ho, John C. Kraft, II, Mingxin Qian
  • Patent number: 10238683
    Abstract: A method for promoting entry of an agent (introduced agent) into a cell, the method comprising the step of complexing the introduced agent in the presence of an entry-promoting agent and then exposing to cells, wherein the entry-promoting agent comprises a linear and/or branched or cyclic polymonoguanide/polyguanidine, polybiguanide, analogue or derivative thereof according to the following Formula 1a & b. The method also provides a means for formation of nanoparticles formed between the entry promoting agent and the introduced agent.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: March 26, 2019
    Assignee: THE ROYAL VETERINARY COLLEGE
    Inventors: Liam Good, Kantaraja Chindera, Valentina Gburcik
  • Patent number: 10239919
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: March 26, 2019
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Patent number: 10202422
    Abstract: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: February 12, 2019
    Assignee: AVELAS BIOSCIENCES, INC.
    Inventors: Jesus Gonzalez, Junjie Liu
  • Patent number: 10194854
    Abstract: A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flrmeas signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DRexmeas DRem, and DRem,filtered signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flrmeas signal within the post-equilibration portion of the measurement data set to an IFagent signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 5, 2019
    Assignee: MediBeacon Inc.
    Inventors: Jennifer Keating, Kimberly Shultz, Kate Bechtel, Edward Solomon
  • Patent number: 10188297
    Abstract: A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, an applicator for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: January 29, 2019
    Assignee: Case Western Reserve University
    Inventor: James Basilion
  • Patent number: 10184878
    Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: January 22, 2019
    Assignee: IntelliCyt Corporation
    Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
  • Patent number: 10175239
    Abstract: The present disclosure provides methods, reagents, systems, and devices that target ? lactamase as a biomarker for the sensitive and specific detection of tuberculosis-complex bacteria. Specifically, the present disclosure relates to methods and compositions for the detection of specific ?-lactamase protein and nucleic acid sequences to indicate the presence of tuberculosis-complex bacteria.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: January 8, 2019
    Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventors: Jeffrey D. Cirillo, Michael T. Norman
  • Patent number: 10159738
    Abstract: The present invention concerns metal-organic hybrid solids having a modified outer surface. These solids can be used, for example, for the storage and vectoring of molecules of interest such as pharmaceutically active ingredients, compounds of interest in cosmetics and markers, for example contrast agents. These solids have good results in terms of active drug loading capacities, biocompatibility, stability and controlling the release of the active ingredients encapsulated.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: December 25, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE VERSAILLES-SAINT QUENTIN EN YVELINES, UNIVERSITE PARIS-SUD
    Inventors: Ruxandra Gref, Valentina Agostoni, Samia Daoud-Mahammed, Violeta Rodriguez-Ruiz, Milo Malanga, Laszlo Jicsinszky, Patricia Horcajada-Cortes, Christian Serre
  • Patent number: 10117954
    Abstract: This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: November 6, 2018
    Assignee: The General Hospital Corporation
    Inventors: Thomas Reiner, Edmund J. Keliher, Ralph Weissleder
  • Patent number: 10105455
    Abstract: Disclosed are compositions that comprise a cyclooxygenase-2-selective therapeutic and/or diagnostic agent having a therapeutic and/or diagnostic agent conjugated to a NSAID drug; and a ROS-responsive nanoparticle. Methods of making and using these compositions for drug encapsulation and delivery are also disclosed.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: October 23, 2018
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Lawrence J. Marnett, Jashim Uddin, Thomas A. Werfel, Mukesh Gupta, Brenda C. Crews
  • Patent number: 10076509
    Abstract: Methods and compositions regarding nested nanoparticles comprising polymer nanoparticles encased in a cyclodextrin shell to facilitate sequence-specific drug release.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: September 18, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Elvin Blanco
  • Patent number: 10071084
    Abstract: A nanoparticle including a hydrophobic active ingredient and a polypeptide, as well as a liposome including the nanoparticle and methods of making and using the nanoparticle.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: September 11, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Don-wook Lee, Jung-yong Nam, Hyun-ryoung Kim, Eun-sung Park
  • Patent number: 10060929
    Abstract: A novel imaging reagent and gel-based method for analyzing and comparing phosphoproteomes on the same gel are disclosed herein.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: August 28, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Weiguo Andy Tao, Linna Wang
  • Patent number: 10060854
    Abstract: A non-invasive device for determining the fertility and/or sex of an egg. This device obtains a spectral response, specific to the shell, to an incident light signal. The device has a focusing element configured to focus the incident light signal on a surface portion and/or an internal portion of at least one layer of the shell, and elements for determining the fertility and/or sex of the egg as a function of the spectral response specific to the shell.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: August 28, 2018
    Assignee: TRONICO
    Inventor: Marc Schortgen
  • Patent number: 10053447
    Abstract: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: August 21, 2018
    Assignees: Pierce Biotechnology, Inc, Dyomics GmbH
    Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann
  • Patent number: 10046068
    Abstract: This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 14, 2018
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael J. Rishel
  • Patent number: 9999687
    Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: June 19, 2018
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Kevin Groves, Dorin V. Preda