Intentional Mixture Of Two Or More Micro-organisms, Cells, Or Viruses Of Different Genera Patents (Class 424/93.3)
  • Patent number: 11871752
    Abstract: The disclosure relates to isolated microorganisms—including novel strains of the microorganisms—microbial consortia, and agricultural compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial consortia, and agricultural compositions comprising the same, in methods for imparting beneficial properties to target plant species. In particular aspects, the disclosure provides methods of increasing desirable plant traits in agronomically important crop species.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: January 16, 2024
    Assignee: BIOCONSORTIA, INC.
    Inventors: Peter Wigley, Susan Turner, Caroline George, Thomas Williams, Kelly Roberts, Graham Hymus, Kelvin Lau
  • Patent number: 11844827
    Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: December 19, 2023
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Noga Or-Geva, Eran Ophir, Yaki Eidelstein, Rotem Gidron Budovsky
  • Patent number: 11813230
    Abstract: Provided is a composition comprising a novel strain, a lysate thereof or a culture product thereof, which can demonstrate excellent effects in strengthening skin barrier, moisturizing skin, enhancing skin elasticity or anti-aging, and can be used for a cosmetic composition or health functional food.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: November 14, 2023
    Assignee: COSMAX, INC.
    Inventors: Dong Geol Lee, Seung Hyun Kang, Mi Sun Kim, Min Ji Kim, Myeong Sam Park
  • Patent number: 11810650
    Abstract: Methods are provided for the rational design of stable communities of microbes for benefiting the health of a host organism, including human and/or animal health. The methods describe design of microbial consortia based on providing and/or complementing key functionalities lacking or underrepresented in the microbiome of an organism having a disorder or disease as compared to healthy subjects. The consortia are designed to possess metabolic interdependencies for improved engrafting, stability and performance of the consortium. Compositions that include the designed microbial consortia are provided for treatment of disorders/diseases involving chronic inflammation, infection, and the combination of chronic inflammation and infection including inflammatory bowel disease and related disorders. The compositions are also broadly applicable for the treatment of neurological, metabolic and oncology-related conditions.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: November 7, 2023
    Assignee: Gusto Global, LLC
    Inventors: Daniel van der Lelie, Safiyh Taghavi
  • Patent number: 11793842
    Abstract: The present disclosure provides a method for regulating expression of IL-1? gene, MMP1a gene and TIMP1 gene of chondrocytes using a Lactobacillus plantarum strain TCI227.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: October 24, 2023
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, Chu-Han Huang, Cheng-Yu Ho
  • Patent number: 11707550
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: July 25, 2023
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 11672839
    Abstract: The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections, in particular respiratory bacterial infections such as bacterial pneumonia. More specifically, the present invention is directed to novel bacteriophage strains, and products and cocktails thereof, including F99/10, F110/10, F27/12, Psa_F83/13, Psa_F95/13, F391/08, Kle_F92/15, Kle_F105/15, Kle_F134/15, Kle_F141/15, as well as variants thereof; and methods of using same in the treatment and prevention of bacterial infections, including respiratory infections caused by, e.g., Pseudomonas aeruginosa and/or Klebsiella pneumoniae. The cocktails are used as pharmaceutical compositions either alone or in further combination with other therapies, e.g., antibiotics or other standard and non-standard therapies for respiratory infections.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: June 13, 2023
    Assignees: TECHNECHNOPHAGE, INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SA, TECNIFAR—INDUSTRIA TECNICA FARMACEUTICA, SA
    Inventors: Sofia Valker Córte-Real, Miguel Ângelo Costa Garcia, Clara Isabel Rodrigues Leandro, Ana Raquel Martins Barbosa
  • Patent number: 11633437
    Abstract: The present invention provides a method of treating a disease or condition characterized by inflammation in a subject in need thereof, comprising administering to the subject an effective amount of a Pediococcus acidilactici probiotic. Compositions of Pediococcus acidilactici probiotic are also provided.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: April 25, 2023
    Assignee: IMAGILIN TECHNOLOGY LLC
    Inventors: Jhy-Jhu Lin, Jolinta Lin
  • Patent number: 11514087
    Abstract: A method includes generating, by a processor system, a graph. The graph is based at least in part on a plurality of instances in which operational taxonomic units are identified as being represented within an environment. The method can also include determining, using the processor system, that at least one instance of the plurality of instances corresponds to a false-positive identification of an operational taxonomic unit. The determining is based on the properties of the graph. The method can also include reporting the determination.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: November 29, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Niina S. Haiminen, Laxmi P. Parida
  • Patent number: 11510948
    Abstract: The present invention relates to a microorganism which can act as a biomarker of alcoholic fatty liver disease, and relates to a pharmaceutical composition for preventing or treating alcoholic fatty liver disease, a food composition for preventing or improving alcoholic fatty liver disease, or a probiotics composition for preventing or improving alcoholic fatty liver disease, comprising the strain as an active ingredient.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: November 29, 2022
    Assignee: KOBIOLABS, INC.
    Inventors: Gwangpyo Ko, Boram Seo, Woon Ki Kim, Kyungchan Jeon
  • Patent number: 11492672
    Abstract: Monitoring, analysis and control of fermentation activities includes methods and corresponding systems directed toward agriculture, biofuels, and food production. Complex methods and corresponding systems are provided for classifying a microorganism; profiling a microbiome; sequencing multiple libraries in a single sequencing run; determining a microbiome profile in a sample; and analyzing a material from a location associated with a fermentation process. Additional implementations are directed to methods and corresponding systems for obtaining, deriving, predicting and evaluating microbiome information; control, analysis and direction of fermentation operations; and evaluating, analyzing and displaying microbiome related information in two and three dimensional plots. Yet additional methods and corresponding systems permit identification and analysis of microorganisms capable of imparting beneficial properties to phases of fermentation processes.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: November 8, 2022
    Inventors: Alberto A. Becares, Adrian F. Fernandez
  • Patent number: 11492587
    Abstract: The present invention relates to microbial cells, including but not limited to aerobic bacteria cells and anaerobic bacteria cells, as well as yeast cells, and methods for producing the cells, feed additives and compositions comprising the cells, and uses involving administration of the cells to animals.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: November 8, 2022
    Assignees: Kansas State University Research Foundation, MS BIOTECH, INC.
    Inventors: James Scott Drouillard, Celine Caroline Aperce, Gina Rae Herren, Tara Jo Ellerman, Ciana Marie Scaletti, Katherine Van Jordan, James Morris Lattimer, Scott Beyer, Solange Uwituze, Teresa Lea Douthit, Christina Denise Gunkel
  • Patent number: 11458174
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: October 4, 2022
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Patent number: 11433107
    Abstract: This document provides bacterial compositions. For example, bacterial compositions having a combination of different bacterial strains formulated in a manner to maintain the stability of the bacteria are provided.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: September 6, 2022
    Assignee: Melaleuca, Inc.
    Inventor: Subhendu Nayak
  • Patent number: 11406672
    Abstract: Probiotic compositions containing a consortium of beneficial lactic acid fermenting microbes, bacteria belonging to the Bacilli family, and yeast are disclosed, and methods of using same as human probiotic for ingestion or as an animal feed additive are disclosed.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: August 9, 2022
    Assignee: SUSTAINABLE COMMUNITY DEVELOPMENT, LLC
    Inventors: Matthew T. Wood, Narin Tipsrisukond
  • Patent number: 11389490
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: July 19, 2022
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von MALTZAHN, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Patent number: 11389530
    Abstract: The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: July 19, 2022
    Assignee: Duke University
    Inventors: John H Sampson, Duane A Mitchell
  • Patent number: 11376322
    Abstract: The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: July 5, 2022
    Assignee: Duke University
    Inventors: John H Sampson, Duane A Mitchell
  • Patent number: 11364295
    Abstract: The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: June 21, 2022
    Assignee: Duke University
    Inventors: John H Sampson, Duane A Mitchell
  • Patent number: 11357801
    Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for modulating the abundance of one or more gut microorganisms in a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising a fecal microbe preparation to achieve at least a 2-fold change of the abundance of said one or more fecal microorganisms, wherein said one or more gut microorganisms are selected from the group consisting of Bifidobacterium, Prevotella, Desulfovibrio, Copprococcus, Clostridium, and Bacteroides.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: June 14, 2022
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: James Adams, Dae-Wook Kang, Rosa Krajmalnik-Brown
  • Patent number: 11351248
    Abstract: The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: June 7, 2022
    Assignee: Duke University
    Inventors: John H Sampson, Duane A Mitchell
  • Patent number: 11351207
    Abstract: A composition and method for preventing and/or treating an E. coli-based infection in an animal is described.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: June 7, 2022
    Inventors: Terry Parrott, Laura Payling
  • Patent number: 11324792
    Abstract: Herbal pharmaceutical compositions for the treatment of ano-rectal diseases are provided. The compositions include C. molmol, Gardenia spp, T. erecta, M. ferrea, activated charcoal, probiotic, neem and/or curcumin, cloves, isabgol, pharmaceutical excipients, and optionally a therapeutic agent. The compositions possess properties to control inflammation by lowering levels of inflammatory cytokines and matrix metalloproteinases, prevent capillary bleeding and fragility in mammals, particularly human beings and have wound healing properties.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: May 10, 2022
    Inventor: Kanwaldeep Singh Chadha
  • Patent number: 11278580
    Abstract: The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: March 22, 2022
    Assignee: Pendulum Therapeutics, Inc.
    Inventors: Colleen Cutcliffe, John S. Eid, James H. Bullard, Marcus F. Schicklberger
  • Patent number: 11213556
    Abstract: The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: January 4, 2022
    Assignee: Pendulum Therapeutics, Inc.
    Inventors: Colleen Cutcliffe, John S. Eid, James H. Bullard, Marcus F. Schicklberger
  • Patent number: 11207356
    Abstract: In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: December 28, 2021
    Assignee: Finch Therapeutics Holdings LLC
    Inventor: Thomas Borody
  • Patent number: 11202808
    Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: December 21, 2021
    Assignees: Arizona Board of Regents on Behalf of Arizona State University, Regents of The University of Minnesota, Finch Therapeutics Holdings LLC
    Inventors: James Adams, Rosa Krajmalnik-Brown, Dae-Wook Kang, Michael J. Sadowsky, Alexander Khoruts, Thomas J. Borody
  • Patent number: 11202812
    Abstract: The present invention provides a method of reducing body fat, comprising administering a composition comprising an effective amount of Lactobacillus paracasei or a metabolite thereof to a subject in need thereof. The Lactobacillus paracasei or the metabolite thereof can effectively convert the fatty acid into conjugated linoleic acid, inhibit the accumulation of fat and promote the decomposition of fat in fat cells, and can effectively reduce the percentage of body fat, waist circumference, and hip circumference, and simultaneously increase the muscle mass of the subject.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: December 21, 2021
    Assignee: TCI CO., LTD.
    Inventors: Yung-Hsiang Lin, Chu-Han Huang, Cheng-Yu Ho
  • Patent number: 11191790
    Abstract: Provided are a biologically pure Faecalibacterium butyricigenerans strain AF52-21 deposited under CGMCC Accession No. 1.5206 and a composition including the same and a carrier. A method for treating an inflammation-related disease in a subject in need thereof is also provided. The Faecalibacterium butyricigenerans is useful for treating ulcerative colitis and related disorders.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: December 7, 2021
    Assignee: BGI SHENZHEN
    Inventors: Yuanqiang Zou, Wenbin Xue, Liang Xiao, Xiaoping Li, Jinghong Yu, Chuan Liu
  • Patent number: 11186815
    Abstract: Disclosed are new uses of lactic acid bacteria, in particular Lactobacillus plantarum, for protecting animals from pathogenic bacterial infection, specifically, methods for reducing the mortality rate of animals against infection of pathogenic bacteria, methods for reducing the growth of pathogenic bacteria in the gastrointestinal tract of the animals, as well as methods of increasing and/or stimulating immune system of the animal through the use of such lactic acid bacteria.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: November 30, 2021
    Assignee: Nutraferma, Inc.
    Inventors: Chan Ho Lee, Jung Sun Kang, Won Tak Cho, Kyung Jin Cho, Eric Lohry
  • Patent number: 11135253
    Abstract: The invention relates to microbiology and medicine and can be used to prevent and treat diseases and conditions associated with disruption of normal (autochthonous) microflora (microbiota) in humans or animals. In particular, a solution for recovery or creation of the subject's microflora comprising an active component containing microorganisms isolated from the microflora of the subject or the donor, wherein the active component can be enriched with bacteriophages of said microflora and/or additional microorganisms of the microflora cultivated on a nutrient medium, while the additional microorganisms of the microflora include microorganisms of the microflora that are yet nonculturable in the absence of the host organism, is proposed.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: October 5, 2021
    Inventors: Viktor Veniaminovich Tets, Georgy Viktorovich Tets
  • Patent number: 11053487
    Abstract: The invention relates to the use of an isolated arabinanase enzyme comprising the activities of (1-5)-?-arabinofuranosidic linkage endohydrolysis in (1-5)-?-L-arabinans (EC 3.2.1.99), and hydrolysis of (1-5)-?-arabinofuranosidic linkages at the non-reducing end of ?-L-arabinans or ?-L-arabinose-oligomers (EC 3.2.1.55), particularly an arabinan-degrading enzyme isolated from Arxula adeninivorans as feed additive in livestock breeding. Furthermore, the invention relates to the application of the arabinanase in the production of fruit juices or biofuels.
    Type: Grant
    Filed: August 19, 2018
    Date of Patent: July 6, 2021
    Assignee: BIOPRACT GMBH
    Inventors: Angelika Hanreich, Joachim Pheiffer, Sebastian Worch, Gotthard Kunze, Tobias Schwalenberg, Reinhard Patz
  • Patent number: 11054379
    Abstract: The present disclosure relates to biosensors (10) having a receptor layer (5) and a mediator layer (6), the receptor layer including ethylene receptor molecules. The present disclosure also relates to sensor units (20) comprising one or more biosensors (10) and a controller (11). In some embodiments, one or more sensor units (20) may be in wireless communication with a receiver module or a network gateway.
    Type: Grant
    Filed: February 23, 2020
    Date of Patent: July 6, 2021
    Assignee: Strella Biotechnology, Inc.
    Inventor: Katherine Konstantin Sizov
  • Patent number: 11052121
    Abstract: The invention relates to the use of a bacterial mixture for the prevention and improvement of the state of ungulates suffering from pathologies involving a parasitic or bacterial infection of the foot, said composition comprising: at least one strain of bacteria of the genus Bacillus, and at least one lactic acid bacterium.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: July 6, 2021
    Assignee: Nolivade
    Inventors: Michel Layus, Alexandre Brame
  • Patent number: 11045769
    Abstract: A submerged membrane unit has air diffusers located outside of the membrane area in plan view. The diffusers may be mounted in or below a diffuser case. The diffuser case may have walls to direct bubbles towards the membranes. The diffusers may be drop diffusers, for example as in a single drop diffuser assembly. The membrane unit may have polymeric or ceramic membranes, for example ceramic flat plate membranes. In an example, a rectangular shrouded membrane unit has a diffuser case below it that is rectangular in plan view but trapezoidal in side view, with drop diffusers located in the corners of the diffuser case. In a process of treating high strength wastewater, for example thickening or digesting waste sludge, a membrane unit optionally with ceramic plate membranes is immersed in the wastewater. The membranes are sparged with bubbles produced below but beside the membrane unit in a diffuser case.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: June 29, 2021
    Assignee: OVIVO INC.
    Inventors: Clay Brandon Rich, Rick Whisenant, Clyde Wayne Holliman, Dennis Livingston
  • Patent number: 11044924
    Abstract: The disclosure relates to isolated microorganisms—including novel strains of the microorganisms—microbial ensembles, and compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial compositions, and compositions comprising the same, in methods for modulating the agricultural production of ruminants. In particular aspects, the disclosure provides methods of increasing feed efficiency, and methods of decreasing acidosis.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: June 29, 2021
    Assignee: Native Microbials, Inc.
    Inventors: Mallory Embree, Cameron Martino, Norman Pitt, Jordan Embree, Corey Dodge
  • Patent number: 10973230
    Abstract: Compositions and methods for enhancing plant growth and crop yield in legumes and non-legumes are described. The compositions include lipo-chitooligosaccharides in combination with chitins/chitosans or in combination with compounds or in combination with a herbicide. The method includes applying the compositions to seeds and/or plants either concomitantly or sequentially.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: April 13, 2021
    Assignee: NOVOZYMES BIOAG A/S
    Inventors: Raymond Stewart Smith, Robert Martin Osburn
  • Patent number: 10927416
    Abstract: The present invention relates to the field of detection of colorectal cancer (CRC). Specifically it relates to methods for the early detection, risk screening and monitoring of CRC and/or adenomatous polyps in a human subject based on the quantification of one or more 16S rDNA bacterial sequences in feces. It further relates to the use of said bacterial sequences as biomarkers of colorectal cancer and/or adenomatous polyps; to a kit comprising a reagent and instructions for the quantification of said bacterial sequences; and to nucleic acids for the quantification of said 16S rDNA bacterial sequences.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: February 23, 2021
    Inventors: Mariona Serra Pagès, Librado Jesús García-Gil, Teresa Mas De Xaxars, Xavier Aldeguer Manté
  • Patent number: 10907185
    Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 2, 2021
    Assignee: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
    Inventors: Qiong Cheng, Robert Dicosimo, Arthur Ouwehand, Zheng You, Jian Ping Lai, Zheyong Yu, Zhenghong Zhang
  • Patent number: 10876092
    Abstract: The present invention relates generally to growth of bacteria. More specifically the invention relates to a method for oxidative environment adaptation of anaerobic microorganisms and their use in developing new probiotics. In particular, the present invention provides a method for adaptation of anaerobic microorganisms and selection of more oxygen tolerant anaerobic microorganisms, said method comprising the steps of culturing said microorganisms with a stepwise dual induction of oxidative stress via applied voltage and oxygen diffusion, and a stepwise change of anti-oxidant/oxidized counterpart concentration ratio to adjust the redox state. New strains are also provided.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: December 29, 2020
    Assignee: METABOGEN AB
    Inventors: Muhammad-Tanweer Khan, Fredrik Backhed
  • Patent number: 10876165
    Abstract: The present invention relates to the field of detection of colorectal cancer (CRC). Specifically it relates to methods for the early detection, risk screening and monitoring of CRC and/or adenomatous polyps in a human subject based on the quantification of one or more 16S rDNA bacterial sequences in feces. It further relates to the use of said bacterial sequences as biomarkers of colorectal cancer and/or adenomatous polyps; to a kit comprising a reagent and instructions for the quantification of said bacterial sequences; and to nucleic acids for the quantification of said 16S rDNA bacterial sequences.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: December 29, 2020
    Inventors: Mariona Serra Pagès, Librado Jesús García-Gil, Teresa Mas De Xaxars, Xavier Aldeguer Manté
  • Patent number: 10864235
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 15, 2020
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Patent number: 10821139
    Abstract: Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to treat or prevent a depressive symptom. Prolonged anti-depressive effects can continue after administration of the compositions is ended. Non-limiting examples of a depressive symptom which can be treated or prevented include depressed mood; sadness; anxiety; “empty” feelings; loss of interest or pleasure; irritability; restlessness; changes in appetite or weight; sleep disturbances; lack of or decreased energy; feelings of worthlessness; guilt; helplessness; anger and hostility; difficulty in thinking, concentrating, or making decisions; hopelessness; tiredness; fatigue; memory difficulties; tearfulness; brooding; phobias; excessive worry over physical health; sexual dysfunction; persistent physical symptoms that do not respond to treatment; and combinations thereof.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: November 3, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Gabriela Bergonzelli Degonda, Tiago Alves Nunes, Valerie Marquardt, Jeroen Antonius Johannes Schmitt
  • Patent number: 10788498
    Abstract: Contemplated test kits and methods for food sensitivity are based on rational-based selection of food preparations with established discriminatory p-value. Particularly preferred kits include those with a minimum number of food preparations that have an average discriminatory p-value of ?0.07 as determined by their raw p-value or an average discriminatory p-value of ?0.10 as determined by FDR multiplicity adjusted p-value. In further contemplated aspects, compositions and methods for food sensitivity are also stratified by gender to further enhance predictive value.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: September 29, 2020
    Assignee: Biomerica, Inc.
    Inventors: Elisabeth Laderman, Zackary Irani-Cohen
  • Patent number: 10733214
    Abstract: A method includes generating, by a processor system, a graph. The graph is based at least in part on a plurality of instances in which operational taxonomic units are identified as being represented within an environment. The method can also include determining, using the processor system, that at least one instance of the plurality of instances corresponds to a false-positive identification of an operational taxonomic unit. The determining is based on the properties of the graph. The method can also include reporting the determination.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: August 4, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Niina S. Haiminen, Laxmi P. Parida
  • Patent number: 10711240
    Abstract: The present invention relates to a composition comprising at least one carrier comprising a polysaccharide, at least one antioxidant and at least one amino acid selected from cysteine, lysine, alanine and arginine. It also relates to the use of such a composition for the protection of microorganisms during drying, storage and/or reconstitution, to a culture powder, to a process of making the culture powder and to products comprising the culture powder.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: July 14, 2020
    Assignee: Societe des Produits Neslte S.A.
    Inventors: Edwin Ananta, Biljana Bogicevic, Carsten Cramer, Alexandra Dubois, Judith Gaulocher, Katja Johnson, Jeroen Andre Muller, Matthias Perren, Guenolee Eliane Marie Prioult, Sabine Sres, Wilbert Sybesma
  • Patent number: 10660913
    Abstract: The present invention relates to synergistic compositions which include mixtures of fermentable fibers. These compositions include inulin and arabinoxylan for use in reducing, preventing and/or treating inflammation. The arabinoxylan is partially hydrolyzed arabinoxylan and the ratio of inulin to arabinoxylan and/or partially hydrolyzed arabinoxylan is between 65%/35% by weight and 90%/10% by weight.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: May 26, 2020
    Assignee: Cosucra-Groupe Warcoing SA
    Inventors: Yann Dugenet, Heidi Jacobs, Christian Fougnies, Beatrice Morio, Veronique Coxam, Annick Bernalier
  • Patent number: 10646524
    Abstract: The present disclosure pertains to a compositions and combinations for simultaneous, separate or sequential use which comprises (a) an oncolytic vaccinia virus that expresses a cytokine and a carboxylesterase enzyme, and, preferably, (b) a cancer co-drug, and to their uses for the treatment of cancer.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: May 12, 2020
    Assignee: SILLAJEN, INC.
    Inventors: Tae Ho Hwang, Nam Hee Lee, Euna Cho
  • Patent number: 10617726
    Abstract: The subject invention provides compositions and methods for treating human dermatological conditions by employing a microbiome-centered treatment approach. Preferred embodiments of the invention provide pharmaceutical and cosmetic compositions, and the methods of using the same, comprising a strain of Lactobacillus fermentum bacterium, or bioactive extracts thereof, derived from human microbiota and capable of growing in biofilm phenotype.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: April 14, 2020
    Assignee: QUORUM INNOVATIONS, LLC
    Inventors: Eva A. Berkes, Nicholas T. Monsul, Frederick T. Boehm
  • Patent number: 10576111
    Abstract: Provided herein are methods and compositions related to Bifidobacterium animalis ssp. lactis useful as therapeutic agents.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: March 3, 2020
    Assignee: Evelo Biosciences, Inc.
    Inventors: Peter Sandy, Jacqueline Papkoff, Maria Sizova, Brian Goodman, Humphrey Gardner, Holly Ponichtera