Fungus Patents (Class 424/93.5)
  • Patent number: 10321687
    Abstract: The invention relates to the use of Coniothyrium minitans for controlling moss growth and to a method of controlling moss growth, comprising applying Coniothyrium minitans to an area to be kept free from mosses.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: June 18, 2019
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventor: Sandra Noga
  • Patent number: 10195238
    Abstract: The present invention provides a composition for inhibiting renal cancer cell growth and enhancing kidney function. This composition is constituted of water-soluble base material, plasticity-increasing base material, Antrodia camphorata extract, Ganoderma lucidum extract, and auxiliary enzyme. Differing from the conventional therapeutics treating the glomerulonephritis by administering high-dosage steroid for 1-4 months, the renal function of a patient suffering with serious kidney failure can be obviously enhanced after administering this composition of 7 mg/day/kg to the patient for 20 days. Moreover, because the cell biological experiments have proved that the of the present invention possess the functionality to inhibit renal cancer cell growth, this novel composition can indeed be used with chemotherapy drugs clinically, so as to solve the issue that the chemotherapy drugs cannot effectively inhibit the renal cancer cell growth.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: February 5, 2019
    Assignees: TAIWAN INDIGENA BOTANICA CO., LTD., TAIPEI MEDICAL UNIVERSITY
    Inventors: Cheng-Jeng Tai, Yeu-Ching Shi, Ching-Hua Su
  • Patent number: 10085436
    Abstract: Barrier treatment compositions using conidia of entomopathogenic fungi and methods for applying and using the same for bed bug population control and prevention are disclosed. The compositions and methods of the invention provide residual biopesticides control for bed bug populations using barrier treatment compositions transferring conidia of entomopathogenic fungi to a population of bed bugs providing effective kill within about 24 hours to about 10 days. The compositions and methods provide significantly enhanced horizontal transmission of the conidia of the entomopathogenic fungi providing enhanced bed bug control without detrimental effects of bed bug tolerance, resistance and/or negative impact on humans or animals contacting the residual biopesticides.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: October 2, 2018
    Assignee: The Penn State Research Foundation
    Inventors: Nina E. Jenkins, Alexis M. Barbarin, Edwin G. Rajotte, Matthew B. Thomas
  • Patent number: 10070653
    Abstract: The invention relates to the method for producing the fungus Paecilomyces spp., and to the uses, methods and nematicide compositions for the prevention and/or control and/or eradication of nematodes that form cysts developing in solanaceae cultures. Said invention includes a system for the application of the fungus combined with the rotation of cultures for effectively and efficiently reducing the viability of the cysts of nematodes in solanaceae cultures.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: September 11, 2018
    Assignee: Instituto de Ecologia, A.C.
    Inventors: Gloria Luz Laura Carrion Villarnovo, Tania Isadora Hernandez Leal, Jose Daniel Lopez Lima, Angel Enrique Nunez Sanchez
  • Patent number: 9950021
    Abstract: An anti-cancer active substance from Antrodia Cinnamomea, produced from mycelium of Antrodia Cinnamomea by following steps: (1) culturing mycelium of Antrodia Cinnamomea by liquid fermentation; (2) extracting the thus-obtained mycelium with ethanol and concentrating the extracted solution to obtain an ethanol extract; (3) dissolving the ethanol extract in water, and extracting with equal volume of ethyl acetate to obtain ethyl acetate extract; (4) purifying the ethyl acetate extract by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain an eluate fraction g; and (5) purifying the eluate fraction g by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain a specific eluate fraction which could be purified further to obtain the anti-cancer active substance from Antrodia Cinnamomea.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: April 24, 2018
    Assignee: National Taiwan University
    Inventors: Been-Huang Chiang, Yu-Wei Lin
  • Patent number: 9795135
    Abstract: The present invention relates to novel compositions and/or formulations, to a process for preparing these compositions and/or formulations and to the use thereof as biologically active compositions and biologically active compositions and/or formulations, especially for the control of phytopathogenic fungi in plants, in the protection of materials and as plant growth regulators.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: October 24, 2017
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Andreas Goertz, Mazen Es-Sayed
  • Patent number: 9730455
    Abstract: The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Paecilomyces lilacinus strain 251 (AGAL No. 89/030550) and Coniothyrium minitans CON/M/91-08 (DSM 9660) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against nematodes, insects and/or phytopathogens, and at least one insecticide (I) selected from the group consisting of acetylcholinesterase (AChE) inhibitors, nicotinic acetylcholine receptor (nAChR) agonists, nicotinic acetylcholine receptor (nAChR) allosteric activators, nicotinic acetylcholine receptor (nAChR) channel blockers and ryanodine receptor modulators in a synergistically effective amount. Furthermore, the present invention relates to a kit of parts comprising said composition and the use of said composition.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: August 15, 2017
    Assignee: Bayer CropScience AG
    Inventors: Wolfram Andersch, Wolfgang Thielert, Bernd Springer, Peter Luth, Ute Eiben
  • Patent number: 9631242
    Abstract: The invention provides a method and compositions for detecting the presence of viable endophyte in a plant, the method comprising germinating seed and excising a young leaf, optionally preparing an extract from the young leaf, and performing antibody, nucleic acid, or preferably PCR-based methods to detect the viable endophyte, wherein at least one primer hybridizes to the intergenic region (IGS) of the ribosomal repeat region of a specific endophyte when used in a PCR-based method. The invention provides a new method for rapid identification of both viable beneficial endophytes and any viable contaminating endophytes, as opposed to any non-viable endophytes, by detecting the presence of endophytes in the first leaf of germinated plants.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: April 25, 2017
    Assignee: GRASSLANZ TECHNOLOGY LIMITED
    Inventors: Richard David Johnson, Christine Rosalie Voisey
  • Patent number: 9474776
    Abstract: The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and mixtures of species, to provide an armamentarium of defenses from multiple stressors in order to help bees survive a complex of symptoms collectively called colony collapse disorder (CCD). More particularly, the present invention utilizes specific concentrations of extracts from pure cultured mycelium from mushroom forming fungi to reduce harmful viruses in bees and to increase the longevity of bees.
    Type: Grant
    Filed: March 8, 2015
    Date of Patent: October 25, 2016
    Inventor: Paul Edward Stamets
  • Patent number: 9364005
    Abstract: The disclosure provides materials and methods for conferring improved plant traits or benefits on plants. The materials can include a formulation comprising an exogenous endophytic bacterial population, which can be disposed on an exterior surface of a seed or seedling, typically in an amount effective to colonize the plant. The formulations can include at least one member selected from the group consisting of an agriculturally compatible carrier, a tackifier, a microbial stabilizer, a fungicide, an antibacterial agent, an herbicide, a nematicide, an insecticide, a plant growth regulator, a rodenticide, and a nutrient.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: June 14, 2016
    Assignee: AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
    Inventors: Birgit Mitter, Milica Pastar, Angela Sessitsch
  • Patent number: 9084750
    Abstract: The antifungal mixture is designed for fighting human diseases and animal diseases of fungal, bacterial or other origin and for violation of bio-films on heterogeneous materials used both in human and veterinary medicine and for elimination of microflora from various objects coming in contact with humans or animals. The antifungal mixture uses the active component of the fungal organism Pythium oligandrum in the mixture with inert components; the said antifungal mixture contains 0.001 to 25 weight portions of the fungal organism Pythium oligandrum and 75 to 99.999 weight portions of inert components. The activity of the fungal organism Pythium oligandrum in the mixture arises at the moment when this organism gets in touch with humidity.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: July 21, 2015
    Assignee: Bio Agens Research and Development-Bard, s.r.o.
    Inventors: Martin Suchánek, Radim Klime{hacek over (s )}
  • Publication number: 20150148232
    Abstract: The combination of a Trichoderma virens species and a rhizosphere competent Trichoderma harzianum species is used to control plant diseases and enhance plant growth.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 28, 2015
    Inventors: William Randolph MARTIN, JR., Christopher Kent HAYES
  • Publication number: 20150141244
    Abstract: The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.
    Type: Application
    Filed: May 29, 2013
    Publication date: May 21, 2015
    Applicant: Bayer Cropscience AG
    Inventors: Elke Hellwege, Wolfram Andersch, Klaus Stenzel, Bernd Springer
  • Publication number: 20150140013
    Abstract: Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventor: Sridhar RAMASWAMY
  • Publication number: 20150125923
    Abstract: The present invention generally relates to compositions and methods of delivering substances in a dry mode, wherein the compositions include a surface layer disposed on the outer surface of the composition that is permeable to carbon dioxide and oxygen. The compositions may be used to deliver microorganisms to remove contaminates, such as oil, chemical, waste, or sewage, from soil, water, or air. In other embodiments, the compositions can also be used for delivering liquid food, liquid food additives, liquid biotech agricultural ingredients, conventional liquid agricultural ingredients, liquid human wellness and dietary supplements, and liquid fragrances and beauty products.
    Type: Application
    Filed: October 5, 2011
    Publication date: May 7, 2015
    Applicant: DryLet LLC
    Inventors: Ramiro Trevino, Steven R. Ellis
  • Publication number: 20150126365
    Abstract: The invention provides a synthetic combination of a crop and at least one fungal endophyte, wherein the crop is a host plant of the endophyte. Provided are also methods and compositions for producing such synthetic combinations. The endophyte reproduces and enhances the agronomic characteristics of the crop. Methods for inoculating the host plant with the endophyte, for propagating the host-endophyte combination, and for detecting the presence of the endophyte and of its metabolites within a host plant are also described.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Inventor: Gregory A. Sword
  • Patent number: 9023339
    Abstract: A method for controlling nematodes in or on a plant, a plant part, and/or a locus for plant growth is provided, the method comprising applying to a plant, plant part, or locus for plant growth in need of protection from said nematodes an effective amount of Bacillus pumilus, a mutant of Bacillus pumilus, or at least one metabolite of Bacillus pumilus. In particular, the Bacillus pumilus strain may be strain QST2808.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: May 5, 2015
    Assignee: Bayer CropScience LP
    Inventors: Nathan Royalty Reed, Philip Thomas Varghese
  • Patent number: 9011891
    Abstract: A formulation containing conidia of non-toxigenic strains of fungi is a useful biocontrol agent for preventing toxin contamination in agricultural commodities, especially those for human and animal consumption such as peanuts, corn, cotton and tree nuts. The formulation of the invention is a water dispersible granule formulation suitable for spraying and includes non-toxigenic and/or non-aflatoxigenic Aspergillus flavus strains capable of inhibiting growth of fungi which produce aflatoxin and further capable of suppressing production of aflatoxin by the toxigenic fungi. A method of preparing the formulation is shown.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: April 21, 2015
    Assignee: The United States of America, as represented by The Secretary of Agriculture
    Inventors: Margaret Lyn, Hamed K. Abbas, Robert Zablotowicz
  • Publication number: 20150104426
    Abstract: Disclosed is a composition for skin external application containing a Pleurotus ferulae fruiting body extract, a Pleurotus ferulae mycelium extract or a liquid culture obtained by culturing the Pleurotus ferulae mycelium. More specifically, disclosed is a functional composition for skin external application containing 0.001 to 90.0% by weight of a Pleurotus ferulae fruiting body extract, a Pleurotus ferulae mycelium extract or a liquid culture obtained by culturing the Pleurotus ferulae mycelium, with respect to the weight of the composition, wherein the composition is potently effective in scavenging active oxygen, preventing aging, acting wrinkles, facilitating collagen synthesis, moisturizing skin, whitening skin, reducing skin irritation, preventing acne, alleviating atopy, providing anti-inflammation, preventing hair damage, preventing alopecia and improving hair growth.
    Type: Application
    Filed: January 27, 2014
    Publication date: April 16, 2015
    Applicant: AMI Cosmetic Co., Ltd.
    Inventors: Kyung Rok Lee, Il Hong, Do Gyeong Lee, Jung No Lee, Soo Yeon Choi, Nu Rim Lee
  • Publication number: 20150098928
    Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R2; R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R21; R21 is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, CN or NO2; and Q is as defined in the disclosure.
    Type: Application
    Filed: January 6, 2014
    Publication date: April 9, 2015
    Applicant: E.I. du Pont de Nemours and Company
    Inventors: George Philip Lahm, Ty Wagerle, Ming Xu
  • Publication number: 20150056169
    Abstract: Despite efforts of eradication and sanitation, Phytophthora ramorum persists in the United States and has been a problem in commercial nurseries since 2001. Detection in a nursery immediately causes the nursery to be under quarantine until the P. ramorum can be proven to be eradicated. Treatment with the biological control agent Trichoderma asperellum showed promise in laboratory results to remediate P. ramorum-infested potting soil. Sixteen T. asperellum isolates were screened, found to have variable mycoparasitic activities, and further tested in natural field settings. Field plots having P. ramorum-infested soil were treated with T. asperellum, a chemical and two different commercial biological control products and compared to non-treated infested soil. After 8 weeks, P. ramorum populations were not detected in the soil treated with T. asperellum isolate 04-22 showing that T. asperellum isolate 04-22 could remediate soils infested with P. ramorum under natural field conditions.
    Type: Application
    Filed: August 20, 2013
    Publication date: February 26, 2015
    Inventors: Timothy L. Widmer, Gary J. Samuels
  • Publication number: 20150050244
    Abstract: The present invention provides a strain of entomopathogenic Beauveria bassiana, compositions comprising the entomopathogenic fungi strain or metabolites of the strain, and the use of the entomopathogenic fungi strain and compositions as biological control agents. Methods for the biological control of phytopathogenic insects using an entomopathogenic Beauveria bassiana fungi strain or one or more metabolites thereof, optionally together with other entomopathogenic fungi including fungi selected from strains of Lecanicillium spp., Paecilomyces fumosoroseus, and compositions comprising said fungi or metabolites thereof are also provided.
    Type: Application
    Filed: May 5, 2014
    Publication date: February 19, 2015
    Applicant: Greentide Limited, a New Zealand Company
    Inventor: Stephen Reynold FORD
  • Publication number: 20150038329
    Abstract: Disclosed are compounds of Formula 1, wherein R1 is phenyl or pyridinyl, each optionally substituted with Q and up to 3 substituents independently selected from R2; each R2 is independently halogen, cyano, SF5, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio or C1-C4 haloalkylthio; and Q is phenyl or pyridinyl, each optionally substituted with up to 5 substituents independently selected from the group consisting of halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy and C1-C4 haloalkoxy. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
    Type: Application
    Filed: October 22, 2014
    Publication date: February 5, 2015
    Inventor: THOMAS FRANCIS PAHUTSKI, JR.
  • Publication number: 20150037323
    Abstract: The present invention refers to monoclonal humanized antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
    Type: Application
    Filed: July 15, 2014
    Publication date: February 5, 2015
    Applicant: U3 PHARMA GMBH
    Inventors: Peter WIRTZ, Jens RUHE, Takeshi TAKIZAWA, Tomoko TAKAYAMA
  • Patent number: 8932825
    Abstract: The present invention relates to host cells having modified lipid-linked oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified lipid-linked oligosaccharides are created or selected. N-glycans made in the engineered host cells have a GlcNAcMan3GlcNAc2 core structure which may then be modified further by heterologous expression of one or more enzymes, e.g., glycosyl-transferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: January 13, 2015
    Assignee: GlycoFi Inc.
    Inventors: Stefan Wildt, Robert Gordon Miele, Juergen Hermann Nett, Robert C. Davidson
  • Publication number: 20150011389
    Abstract: The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (A) Fluopyram and (B) one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
    Type: Application
    Filed: January 22, 2013
    Publication date: January 8, 2015
    Inventor: Elke Hellwege
  • Patent number: 8926961
    Abstract: The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its amino acid sequence and Human Leukocyte Antigen restriction. These epitopes are identified based on their ability to induce specific T cell responses and therefore, are important as sources of antigens for immunotherapies to treat cervical and other cancers. The present invention contemplates identifying a number of similar epitopes restricted by a wide variety of Human Leukocyte Antigen types so that they can be used together to develop preventative or therapeutic vaccines, which can be used for the general human population. The present invention also contemplates using E6 peptides of Human Papilloma virus as a diagnosis method to predict the probability of developing persistent cervical neoplasia in an individual.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: January 6, 2015
    Assignee: Board Of Trustees of The University Of Arkansas
    Inventor: Mayumi Nakagawa
  • Patent number: 8926962
    Abstract: Treatment of plants against infection by oomycetes. The invention refers to a new strain of Phoma useful for manufacturing a plant-care composition intended to treat plants against phytopathogenic oomycetes. This new strain was deposited on Feb. 25, 2010 with the Collection Nationale de Cultures de Microorganismes of the Institut Pasteur in Paris, France under the CNCM number I-4278.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: January 6, 2015
    Assignee: Institut National de la Recherche Agronomique (INRA)
    Inventors: Eric Galiana, Michel Ponchet, Antoine Marais
  • Patent number: 8921400
    Abstract: This invention provides a composition comprising a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure, and an effective amount of at least one fungicide.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: December 30, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
  • Patent number: 8911959
    Abstract: Coccidioidomycosis (Valley Fever) is currently diagnosed by relying on infected individuals (humans, dogs, etc.) to generate antibodies against the fungus. Since the immune response against Valley Fever can be delayed or absent in many cases, methods that detect a polypeptide or peptide component of the Coccidioides sp. fungus in a bodily fluid such as blood are provided.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: December 16, 2014
    Assignees: Arizona Board of Regents, a body corporate of the State of Arizona Acting for and on behalf of Arizona State University, Mayo Foundation for Medical Education and Research
    Inventors: Douglas Lake, Kwasi Antwi, Janis E. Blair
  • Patent number: 8906361
    Abstract: A dietary supplement based on blue green algae, phycocyanin and phenylethylamine is fortified with one or more of curcumin, silymarin, resveratrol, astragalus root extract, astragoloside IV, vitamin D3, vitamin C, anhydrous trimethylglycine and brewer's yeast to stimulate stem cell production and reduce the rate of telomere reduction or shortening. This can result in the repair of existing body cells and enhance longevity by stimulating the production of new stem cells and maintaining the telomeres on new stem cells as well as existing cells. The dietary supplement supports an increased life span by enhancing metabolic function, activating SIRT-1 anti-aging genes, and encouraging the production of new cells with longer telomeres.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: December 9, 2014
    Inventor: John V. Cappello
  • Patent number: 8883679
    Abstract: The present invention relates to liquid mycorrhiza compositions and to methods for colonizing a plant, grass, tree or shrub with one or more mycorrhizas.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: November 11, 2014
    Assignee: Novozymes A/S
    Inventors: Kristi Woods, Erin Divers
  • Publication number: 20140323305
    Abstract: The present invention relates to the use of strobilurine type compounds of formula I and the N-oxides and the salts thereof for combating phytopathogenic fungi containing a mutation in the mitochondrial cytochrome b gene conferring resistance to Qo inhibitors, and to methods for combating such fungi. The invention also relates to novel compounds, processes for preparing these compounds, to compositions comprising at least one such compound, to plant health applications, and to seeds coated with at least one such compound.
    Type: Application
    Filed: December 6, 2012
    Publication date: October 30, 2014
    Applicant: BASF SE
    Inventors: Joachim Rheinheimer, Violeta Terteryan, Stefan Redlich, Doris Kremzow, Claudia Rosenbaum, Sebastian Georgios Rohrer, Wassilios Grammenos, Christian Pilger, Franz Roehl, Markus Gewehr, Gerd Stammler, Jurith Montag, Hubert Sauter
  • Patent number: 8871197
    Abstract: A new and distinct variety of higher Basidiomycetes mushroom Cyathus striatus HAI-1302, and extracts thereof are provided. These extracts as well as pharmaceutical composition comprising them are capable of inhibiting growth of cancer cells, arresting cancer cell cycle, reducing DNA synthesis in cancer cells and inducing apoptosis in cancer cells, and are thus useful for the treatment of cancer.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: October 28, 2014
    Assignee: Carmel-Haifa University Economic Corporation Ltd.
    Inventors: Fuad Fares, Lital Shavit, Solomon P. Wasser
  • Patent number: 8871492
    Abstract: A fat-soluble fraction extracted from the fruiting body of Hericium erinaceum is demonstrated to inhibit the neuronal toxicity of amyloid beta-peptide (A?) and induce the synthesis of nerve growth factor (NGF), and has great potential as an active ingredient for pharmaceutical products, health food products, food products and/or beverages to prevent and/or treat dementia, especially Alzheimer-type dementia. This invention is to provide the bioactive fraction and its preparation method.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: October 28, 2014
    Inventors: Cun Zhuang, Hirokazu Kawagishi, Luyong Zhang, Hideo Anzai
  • Publication number: 20140308222
    Abstract: The present invention relates to an extract of Dionaea muscipula and a composition comprising such an extract for cosmetic treatment of the skin and skin appendages such as sebaceous glands, hair and nails especially skin changes due to accelerated or chronological aging e.g. wrinkles loss of firmness and elasticity, and increased pigmentation. It also regards the use of such an extract for the preparation of a composition for cosmetic treatment. The composition may comprise further substances active against skin changes due to accelerated or chronological aging e.g. wrinkles, loss of firmness and elasticity, and increased pigmentation. Especially it may contain an extract from Cymbidium erythraeum. It may also comprise bases, cosmetic pigments, UV filters and/or UV scattering agents. The scope of the invention also covers a method for cosmetic treatment of the skin, especially skin changes due to accelerated or chronological aging e.g.
    Type: Application
    Filed: April 18, 2014
    Publication date: October 16, 2014
    Applicants: QUANTUM PHARMACEUTICALS LTD., Royal Government of Bhutan, Ministry of Agriculture
    Inventors: Atti-La DAHLGREN, John DAHLGREN, Tashi Yangzome DORJI, Singay DORJI, Sherub GYALTSHEN
  • Publication number: 20140308249
    Abstract: The present invention provides a stabilized water dispersible granule biocontrol composition comprising at least one non-toxigenic strain of Aspergillus, at least one water-soluble filler and at least one anionic surfactant.
    Type: Application
    Filed: May 24, 2012
    Publication date: October 16, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Tammy Lynn Tyler, James Alan Swanson
  • Publication number: 20140256544
    Abstract: Coating composition for an oilseed plant seed from which roots and shoots are capable of growing, wherein the coating composition comprises an organic carrier material and one or more biological agents that possess an activity against at least one or more pathogens of the oilseed plant.
    Type: Application
    Filed: April 19, 2012
    Publication date: September 11, 2014
    Applicant: EXOSECT LIMITED
    Inventor: Nicholas Hugh Hylton Jessop
  • Publication number: 20140242036
    Abstract: The instant invention refers to a novel process for potentiating the production of substances with antifungal activity obtained from Ganoderma lucidum, using a technological device for the differential, qualitative and quantitative expression of proteins and other bioactive molecules, selected from the group consisting of polysaccharides, triterpenoids, fatty acids and ganoderic acids. The compositions containing said substances showed antifungal activity and mycelium growth and fungi ascospore germination inhibiting activity, amongst them Mycosphaerella fijiensis, primary pathogenic agent causing black Sigatoka disease in banana and plantain crop fields.
    Type: Application
    Filed: June 18, 2013
    Publication date: August 28, 2014
    Inventors: JOHN JAIRO MIRA CASTILLO, PAOLA ANDREA ZAPATA OCAMPO, LUCíA ATEHORTÚA GARCÉS, LIUDA JOHANA SEPÚLVEDA ARANGO, DIEGO FERNANDO ROJAS VAHOS
  • Publication number: 20140228212
    Abstract: Combinations suitable for agricultural use can include (I) a nematode-antagonistic biocontrol agent and (II) one or more agents selected, independently of each other, from any one of (A) to (H): (A) at least one fungicide; (B) at least one insecticide; (C) at least one synthetic nematicide; (D) bacterium of the genus Bacillus; (E) Harpin; (F) Isoflavones; (G) Plant growth regulators; and/or (H) Plant activators.
    Type: Application
    Filed: April 13, 2012
    Publication date: August 14, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Palle Pedersen, Clifford George Watrin, Michael Oostendorp, Andre Luiz-Freitas de Oliveira
  • Publication number: 20140212387
    Abstract: The invention relates to a liquid preparation comprising biologically active fungi and/or fungal organs and/or other microorganisms in a suspension, to a method for producing it and to the use thereof for biological protection of plants, for biological plant strengthening, or for biological soil improvement. Polyether-modified trisiloxane is a preferred liquid used. The preparation according to the invention is notable for easily manageable storage at room temperature, trouble-free transport, and simplicity of production and application.
    Type: Application
    Filed: May 18, 2012
    Publication date: July 31, 2014
    Inventor: Peter Lüth
  • Patent number: 8790662
    Abstract: The invention is based, in part, on the discovery of a novel cell-based immunotherapy that can recapitulate neutrophil functions in neutropenic individuals afflicted with a microbial infection. The therapeutic methods of the invention are broadly applicable to treat any infection in a neutropenic individual, including infections caused by bacteria, fungi, protozoa, and viruses. The methods of the invention represent a practical, rapid cell-based immunotherapy for refractory infections comprising compositions of activated, irradiated HL-60 cells.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: July 29, 2014
    Assignee: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
    Inventors: Brad J. Spellberg, Ashraf S. Ibrahim, John E Edwards, Jr.
  • Patent number: 8789310
    Abstract: Disclosed herein is a method for airfield management comprising the use of fine fescue grasses at airfield installations that results in environmental benefits to airports, including protection of human life and wildlife; reduced gas emissions from decreased mowing, decreased storm water runoff due to deeper and larger root systems of vegetative cover, increased soil stabilization, moderation of airport temperatures and heat effects to the atmosphere, and tremendous financial savings to the aviation industry and consequently to the public.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: July 29, 2014
    Inventor: Christina Kobland
  • Publication number: 20140205850
    Abstract: The present invention relates to a method for reducing wetwood content in green lumber by a treatment with a selected fungal species, such as Phlebiopsis gigantea or Gliocladium roseum, prior to kiln drying. In the laboratory conditions, the biological treated boards reduced wood moisture content (MC) by 22-37% more than untreated boards. The time required for drying biological treated boards was approximately reduced by 10% compared with untreated controls, and by 33% compared with freshly-saw lumber. After drying, the biological treated boards reduced the total deformation with stain, warping and checking by 14-25%.
    Type: Application
    Filed: July 27, 2011
    Publication date: July 24, 2014
    Applicant: FPINNOVATIONS
    Inventors: Dian-Qing Yang, Marc Savard
  • Publication number: 20140201868
    Abstract: The present invention relates to fungi of Acremonium spp, wherein said fungi are purified or isolated from plants of the Brachiaria-Urochloa complex and wherein, when said fungi are inoculated into a plant, said plant has improved resistance to diseases and/or pests relative to an uninocualated control plant. The present invention also relates to plants inoculated with such fungi, products produced by the fungi and related genes, proteins and methods.
    Type: Application
    Filed: June 1, 2012
    Publication date: July 17, 2014
    Applicant: AGRICULTURE VICTORIA SERVICES PTY LTD
    Inventors: German Carlos Spangenberg, Kathryn Michaela Guthridge
  • Patent number: 8771676
    Abstract: The present invention provides an agrochemically active microbial formulation comprising a combination of an agrochemically active microbe with a specified ester compound and a surfactant, the formulation exhibiting a stable pest controlling effect with no harmful effect on a plant and having highly stable viability of the agrochemically active microbe.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: July 8, 2014
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Shinya Kimura, Yoshiki Takashima, Takeshi Maruyama
  • Publication number: 20140187423
    Abstract: The present invention relates to substituted 1-{2-[2-halo-4-(4-halogen-phenoxy)-phenyl]-2-alkoxy-hexyl}-1H-[1,2,4]triazole compounds of formula I as defined in the description, and the N-oxides, and salts thereof, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound. The invention also relates to the use of such compounds and compositions for combating harmful fungi and seed coated with at least one such compound.
    Type: Application
    Filed: August 14, 2012
    Publication date: July 3, 2014
    Applicant: BASF SE
    Inventors: Jochen Dietz, Richard Riggs, Nadege Boudet, Jan Klaas Lohmann, Ian Robert Craig, Egon Haden, Erica May Wilson Lauterwasser, Bernd Mueller, Wassilios Grammenos, Thomas Grote
  • Publication number: 20140178342
    Abstract: The invention relates to a method for treating skin diseases using live “Penicillium notatum” fungus. There is still little known about the “Penicillium notatum” fungus. Live “Penicillium notatum” fungus has the following functions in the treatment process: 1) as a biological producer to develop the most effective antibiotic against (particular) pathological microorganisms acting as the causative agents of a particular disease; 2) as a biological therapeutic instrument for the rational delivery of an antibiotic individually to each pathogenic microorganism; 3) as a biological instrument for the removal of dead and infected human body tissues; 4) as a biological immunizing agent protecting young regenerating skin; 5) as a biological immunizing agent protecting young skin tissue that has not succeeded to establish immunity after regeneration against a repeated attack from the disease. The treatment period for certain infectious skin diseases using live “Penicillium notatum” fungus lasts from three to five days.
    Type: Application
    Filed: August 5, 2011
    Publication date: June 26, 2014
    Inventor: Konstantin Evstafyevich Chernov
  • Patent number: 8759056
    Abstract: A process for the production of granules or pellets containing filamentous fungi is described comprising the steps of selecting and growing filamentous fungi in a suitable culture medium for a predetermined amount of time, adding a gelling agent and at least one carrier to said culture medium, so as to obtain a mixture, subjecting said mixture to gelling through contact, drop by drop, with a solution containing a calcium salt thus obtaining gelled pellets or granules containing said filamentous fungi and drying said gelled pellets or granules to a moisture content of 13-18%.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: June 24, 2014
    Assignee: Urea Casale SA
    Inventor: Elisabeth Panchaud-Mirabel
  • Patent number: 8753656
    Abstract: The present invention utilizes extracts of the pre-sporulation (preconidial) mycelial stage of entomopathogenic fungi as insect and arthropod attractants and/or pathogens and can be employed to limit the zoonotic diseases they transmit. The fungus can be cultivated on grain, wood, agricultural wastes or other cellulosic material and extracts can be made thereof. More than one fungus and substrate can be used in combination with one or more antimicrobial, antiprotozoal, antiviral, and genetically modified agents that result in reduced spread of contagions and lessens the damage they inflict on animals, and plants.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: June 17, 2014
    Inventor: Paul Stamets