Abstract: The present disclosure provides a process for preventing, and alleviating citrus greening infection of citrus plants including identifying the causative agent, providing consortia comprising Trichoderma spp. and Pseudomonas spp. in definite ratios effective in targeting the causative agent Phytophthora spp. and thereby preventing or alleviating the citrus greening disease in an effective manner. The present disclosure also provides consortia comprising standardized cultures of Trichoderma spp. in varying ratios and Pseudomonas spp. in varying ratios effective in preventing and controlling the causative agent Phytophthora spp. at different ages of citrus plants and stages of infection. The present disclosure further provides formulations comprising the antagonist microbial consortia and tailor made kits comprising one or more formulations of the present disclosure for managing citrus greening disease.

Abstract: The invention generally relates to methods of producing loline alkaloids or precursors thereof, expression constructs, and host cells useful for producing loline alkaloids or precursors thereof, and methods for producing loline alkaloids or precursors thereof in a host cell.

Abstract: A method of controlling or preventing pathogenic damage and/or pest damage in a plant propagation material, a plant, part of a plant and/or plant organ, comprising applying on the plant, part of the plant, plant organ, plant propagation material or a surrounding area thereof a phytoprotective agent comprising an enzyme and a fungicide.

Abstract: A method for preventing or combating a fungal infection on a stone fruit tree or a part thereof includes applying Trichoderma atroviride strain SC1 to the tree, the part thereof, or a locus of the tree. The Trichoderma atroviride strain SC1 is useful in the prevention or combat of a fungal infection on a stone fruit tree or a part thereof.

Abstract: The invention relates to biocontrol compositions comprising an entomopathogenic fungus, kits comprising such an entomopathogenic fungus, and methods of using such a fungus and compositions to reduce or kill the population of agricultural, vegetable, or horticultural crop insect pests.

Abstract: The present invention relates to a method of treating or preventing a house dust mite infestation, said method comprising applying an acaricidal infectious agent at a site of a house dust mite infestation, or at a site proximal thereto, or at a site at risk of such infestation. Also encompassed are uses of acaricidal infectious agents, methods of isolating acaricidal infectious agents, acaricidal infectious agents obtainable by said methods, acaricidal infectious agent formulations, foodstuffs and mite attractants comprising the same.

Abstract: The present subject matter includes novel chemical formulations having antimicrobial, antifungal, antiseptic, and related effect in a wide range of applications for treating or preventing infections as well as treating various surfaces that may become tainted with infectants. In some embodiments, the formulation includes isoamyl hexanoates and at least one of propanoic and/or isobutyric acid.

Abstract: A fungal strain of the genus Trichoderma with the designation HSA12 and compositions that contain said fungal strain or spores thereof is disclosed. The fungal strain or spores thereof are promoting stabilizing plant growth, increasing the yields of crops, inoculating soil, roots and/or above-ground plant parts with the fungal strain or spores with compositions containing said fungal strain or spores thereof, to increase the efficiency of nutrient intake and to improve the stress tolerance of crops as well as improving the structure and health of the soil or for decontaminating or remediating soil or a body of water and for stabilizing or reestablishing endangered or desired wild plant populations. Also disclosed is a set of primer pairs for amplifying microsatellite loci of the genome of the fungal strain in order to determine molecular markers and to identify the fungal strain. A method for determining the fungal strain is also disclosed.

Abstract: The present invention relates to pesticidal mixtures comprising as active components at least one active compound selected from compounds of formula I, formula Ia, and mixtures thereof and at least one biopesticide II. Furthermore, the present invention relates to seed treatment compositions comprising said mixtures, to methods and uses comprising the application of these mixtures and to seeds comprising the mixtures of the invention or a seed treatment composition thereof.

Abstract: The invention relates to the field of protecting plants against pests, and more particularly to a method of protecting plants against pests, which can be used for industrial and scientific purposes, in agriculture, horticulture and forestry. The method of protecting plants against pests according to the present invention comprises applying a biologically active preparation pre-activated in an aqueous medium to a plant, the preparation comprising microcontainers and a biological insecticide, wherein the microcontainers are made from a polymeric material in the form of a hollow receptacle with at least one opening, via which the biological insecticide is placed inside the microcontainers. The invention also provides a microcontainer and a preparation for realisation of the stated method. Furthermore, the invention provides methods for producing a microcontainer and the aforementioned preparation.

Abstract: Provided are polypeptides and compositions comprising novel HSP-binding peptides. Such polypeptides and compositions are particularly useful as immunotherapeutics (e.g., cancer vaccines). Also provided are methods of inducing a cellular immune response using such polypeptides and compositions, methods of treating a disease using such polypeptides and compositions, kits comprising such polypeptides and compositions, and methods of making such compositions.

Abstract: A peptide-containing composition includes a peptide and an alkaline mineral carrier, wherein an amount of the alkaline mineral carrier is 8 parts by mass or more based on 100 parts by mass of the peptide. A method for cultivating a plant includes applying a peptide-containing composition to the plant, a method for improving stability of a peptide includes mixing an alkaline mineral carrier with the peptide, and a method for storing a peptide includes storing the peptide in coexistence with an alkaline mineral carrier.

Abstract: A composition for controlling plant diseases comprising Paecilomyces fumosoroseus, and one or more nematicidal active ingredients selected from specific groups has an excellent controlling effect on plant diseases.

Abstract: The invention relates to the use of Coniothyrium minitans for controlling moss growth and to a method of controlling moss growth, comprising applying Coniothyrium minitans to an area to be kept free from mosses.

Abstract: Disclosed herein is an isolated Muscodor albus strain producing volatile organic compounds such as aristolene, 3-octanone and/or acetic acid ester, as well as cultures of said strain and compositions, metabolites and volatiles derived from said strain or culture as well as methods of obtaining said compositions, metabolites and volatiles and their methods of use for controlling pests. Also disclosed are artificial compositions having the same components and uses as the volatiles derived from the strain. A method for capturing and sampling the volatiles is also disclosed.

Abstract: The invention relates to enhanced tulathromycin for use in the treatment, metaphylaxis or prevention of a microbial infection, characterized in that a compound of formula (I) is used in combination with tulathromycin at a weight ratio compound of formula (I):microbial agent of 8:1 to 1:10, and in that the microbial infection is induced in particular by a strain A pathogen in which the concentration of compound (I) satisfies the following equation: [C]<[MIC]/x, where [C] is the concentration according to the invention of compound (I) to be used in strain A, [MIC] is the minimum inhibitory concentration measured for compound (I) alone in strain A, and x is at least 100, advantageously at least 1000, more advantageously between 2000 and 10,000, or even greater than 50,000.

Abstract: The present disclosure provides a method for aseptically culturing fruiting bodies of Antrodia cinnamomea, including: inoculating Antrodia cinnamomea strains in a sterilized agar medium, and performing a subculture to generate secondary mycelia and fruiting bodies of Antrodia cinnamomea.

Abstract: Compositions and methods for repelling coleopterans. The compositions contain a substrate and an anti-aggregation pheremone intermixed within the substrate. The pheremone may be verbenone, methyl salycylate, wintergreen oil, or combinations thereof.

Abstract: The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (A) Fluopyram, (B) a spore-forming bacterium of the genera Bacillus, selected from Bacillus firmus, Bacillus cereus, Bacillus pumilis, Bacillus amyloliquefaciens, Bacillus subtilis strain GB03, Bacillus subtilis strain QST713, and (C) at least one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites.

Abstract: The invention provides a synthetic combination of a crop and at least one fungal endophyte, wherein the crop is a host plant of the endophyte. Provided are also methods and compositions for producing such synthetic combinations. The endophyte reproduces and enhances the agronomic characteristics of the crop. Methods for inoculating the host plant with the endophyte, for propagating the host-endophyte combination, and for detecting the presence of the endophyte and of its metabolites within a host plant are also described.

Abstract: The invention relates to the use of Coniothyrium minitans for controlling moss growth and to a method of controlling moss growth, comprising applying Coniothyrium minitans to an area to be kept free from mosses.

Abstract: The present invention provides a composition for inhibiting renal cancer cell growth and enhancing kidney function. This composition is constituted of water-soluble base material, plasticity-increasing base material, Antrodia camphorata extract, Ganoderma lucidum extract, and auxiliary enzyme. Differing from the conventional therapeutics treating the glomerulonephritis by administering high-dosage steroid for 1-4 months, the renal function of a patient suffering with serious kidney failure can be obviously enhanced after administering this composition of 7 mg/day/kg to the patient for 20 days. Moreover, because the cell biological experiments have proved that the of the present invention possess the functionality to inhibit renal cancer cell growth, this novel composition can indeed be used with chemotherapy drugs clinically, so as to solve the issue that the chemotherapy drugs cannot effectively inhibit the renal cancer cell growth.

Abstract: Barrier treatment compositions using conidia of entomopathogenic fungi and methods for applying and using the same for bed bug population control and prevention are disclosed. The compositions and methods of the invention provide residual biopesticides control for bed bug populations using barrier treatment compositions transferring conidia of entomopathogenic fungi to a population of bed bugs providing effective kill within about 24 hours to about 10 days. The compositions and methods provide significantly enhanced horizontal transmission of the conidia of the entomopathogenic fungi providing enhanced bed bug control without detrimental effects of bed bug tolerance, resistance and/or negative impact on humans or animals contacting the residual biopesticides.

Abstract: The invention relates to the method for producing the fungus Paecilomyces spp., and to the uses, methods and nematicide compositions for the prevention and/or control and/or eradication of nematodes that form cysts developing in solanaceae cultures. Said invention includes a system for the application of the fungus combined with the rotation of cultures for effectively and efficiently reducing the viability of the cysts of nematodes in solanaceae cultures.

Abstract: An anti-cancer active substance from Antrodia Cinnamomea, produced from mycelium of Antrodia Cinnamomea by following steps: (1) culturing mycelium of Antrodia Cinnamomea by liquid fermentation; (2) extracting the thus-obtained mycelium with ethanol and concentrating the extracted solution to obtain an ethanol extract; (3) dissolving the ethanol extract in water, and extracting with equal volume of ethyl acetate to obtain ethyl acetate extract; (4) purifying the ethyl acetate extract by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain an eluate fraction g; and (5) purifying the eluate fraction g by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain a specific eluate fraction which could be purified further to obtain the anti-cancer active substance from Antrodia Cinnamomea.

Abstract: The present invention relates to novel compositions and/or formulations, to a process for preparing these compositions and/or formulations and to the use thereof as biologically active compositions and biologically active compositions and/or formulations, especially for the control of phytopathogenic fungi in plants, in the protection of materials and as plant growth regulators.

Abstract: The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Paecilomyces lilacinus strain 251 (AGAL No. 89/030550) and Coniothyrium minitans CON/M/91-08 (DSM 9660) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against nematodes, insects and/or phytopathogens, and at least one insecticide (I) selected from the group consisting of acetylcholinesterase (AChE) inhibitors, nicotinic acetylcholine receptor (nAChR) agonists, nicotinic acetylcholine receptor (nAChR) allosteric activators, nicotinic acetylcholine receptor (nAChR) channel blockers and ryanodine receptor modulators in a synergistically effective amount. Furthermore, the present invention relates to a kit of parts comprising said composition and the use of said composition.

Abstract: The invention provides a method and compositions for detecting the presence of viable endophyte in a plant, the method comprising germinating seed and excising a young leaf, optionally preparing an extract from the young leaf, and performing antibody, nucleic acid, or preferably PCR-based methods to detect the viable endophyte, wherein at least one primer hybridizes to the intergenic region (IGS) of the ribosomal repeat region of a specific endophyte when used in a PCR-based method. The invention provides a new method for rapid identification of both viable beneficial endophytes and any viable contaminating endophytes, as opposed to any non-viable endophytes, by detecting the presence of endophytes in the first leaf of germinated plants.

Abstract: The present invention is based on a plurality of benefits from the extracts of mycelia of individual fungal species, and mixtures of species, to provide an armamentarium of defenses from multiple stressors in order to help bees survive a complex of symptoms collectively called colony collapse disorder (CCD). More particularly, the present invention utilizes specific concentrations of extracts from pure cultured mycelium from mushroom forming fungi to reduce harmful viruses in bees and to increase the longevity of bees.

Abstract: The disclosure provides materials and methods for conferring improved plant traits or benefits on plants. The materials can include a formulation comprising an exogenous endophytic bacterial population, which can be disposed on an exterior surface of a seed or seedling, typically in an amount effective to colonize the plant. The formulations can include at least one member selected from the group consisting of an agriculturally compatible carrier, a tackifier, a microbial stabilizer, a fungicide, an antibacterial agent, an herbicide, a nematicide, an insecticide, a plant growth regulator, a rodenticide, and a nutrient.

Abstract: The antifungal mixture is designed for fighting human diseases and animal diseases of fungal, bacterial or other origin and for violation of bio-films on heterogeneous materials used both in human and veterinary medicine and for elimination of microflora from various objects coming in contact with humans or animals. The antifungal mixture uses the active component of the fungal organism Pythium oligandrum in the mixture with inert components; the said antifungal mixture contains 0.001 to 25 weight portions of the fungal organism Pythium oligandrum and 75 to 99.999 weight portions of inert components. The activity of the fungal organism Pythium oligandrum in the mixture arises at the moment when this organism gets in touch with humidity.

Abstract: The combination of a Trichoderma virens species and a rhizosphere competent Trichoderma harzianum species is used to control plant diseases and enhance plant growth.

Abstract: Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells.

Abstract: The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

Abstract: The present invention generally relates to compositions and methods of delivering substances in a dry mode, wherein the compositions include a surface layer disposed on the outer surface of the composition that is permeable to carbon dioxide and oxygen. The compositions may be used to deliver microorganisms to remove contaminates, such as oil, chemical, waste, or sewage, from soil, water, or air. In other embodiments, the compositions can also be used for delivering liquid food, liquid food additives, liquid biotech agricultural ingredients, conventional liquid agricultural ingredients, liquid human wellness and dietary supplements, and liquid fragrances and beauty products.

Abstract: The invention provides a synthetic combination of a crop and at least one fungal endophyte, wherein the crop is a host plant of the endophyte. Provided are also methods and compositions for producing such synthetic combinations. The endophyte reproduces and enhances the agronomic characteristics of the crop. Methods for inoculating the host plant with the endophyte, for propagating the host-endophyte combination, and for detecting the presence of the endophyte and of its metabolites within a host plant are also described.

Abstract: A method for controlling nematodes in or on a plant, a plant part, and/or a locus for plant growth is provided, the method comprising applying to a plant, plant part, or locus for plant growth in need of protection from said nematodes an effective amount of Bacillus pumilus, a mutant of Bacillus pumilus, or at least one metabolite of Bacillus pumilus. In particular, the Bacillus pumilus strain may be strain QST2808.

Abstract: A formulation containing conidia of non-toxigenic strains of fungi is a useful biocontrol agent for preventing toxin contamination in agricultural commodities, especially those for human and animal consumption such as peanuts, corn, cotton and tree nuts. The formulation of the invention is a water dispersible granule formulation suitable for spraying and includes non-toxigenic and/or non-aflatoxigenic Aspergillus flavus strains capable of inhibiting growth of fungi which produce aflatoxin and further capable of suppressing production of aflatoxin by the toxigenic fungi. A method of preparing the formulation is shown.

Abstract: Disclosed is a composition for skin external application containing a Pleurotus ferulae fruiting body extract, a Pleurotus ferulae mycelium extract or a liquid culture obtained by culturing the Pleurotus ferulae mycelium. More specifically, disclosed is a functional composition for skin external application containing 0.001 to 90.0% by weight of a Pleurotus ferulae fruiting body extract, a Pleurotus ferulae mycelium extract or a liquid culture obtained by culturing the Pleurotus ferulae mycelium, with respect to the weight of the composition, wherein the composition is potently effective in scavenging active oxygen, preventing aging, acting wrinkles, facilitating collagen synthesis, moisturizing skin, whitening skin, reducing skin irritation, preventing acne, alleviating atopy, providing anti-inflammation, preventing hair damage, preventing alopecia and improving hair growth.

Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R2; R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R21; R21 is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, CN or NO2; and Q is as defined in the disclosure.

Abstract: Despite efforts of eradication and sanitation, Phytophthora ramorum persists in the United States and has been a problem in commercial nurseries since 2001. Detection in a nursery immediately causes the nursery to be under quarantine until the P. ramorum can be proven to be eradicated. Treatment with the biological control agent Trichoderma asperellum showed promise in laboratory results to remediate P. ramorum-infested potting soil. Sixteen T. asperellum isolates were screened, found to have variable mycoparasitic activities, and further tested in natural field settings. Field plots having P. ramorum-infested soil were treated with T. asperellum, a chemical and two different commercial biological control products and compared to non-treated infested soil. After 8 weeks, P. ramorum populations were not detected in the soil treated with T. asperellum isolate 04-22 showing that T. asperellum isolate 04-22 could remediate soils infested with P. ramorum under natural field conditions.

Abstract: The present invention provides a strain of entomopathogenic Beauveria bassiana, compositions comprising the entomopathogenic fungi strain or metabolites of the strain, and the use of the entomopathogenic fungi strain and compositions as biological control agents. Methods for the biological control of phytopathogenic insects using an entomopathogenic Beauveria bassiana fungi strain or one or more metabolites thereof, optionally together with other entomopathogenic fungi including fungi selected from strains of Lecanicillium spp., Paecilomyces fumosoroseus, and compositions comprising said fungi or metabolites thereof are also provided.

Abstract: The present invention refers to monoclonal humanized antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.

Abstract: Disclosed are compounds of Formula 1, wherein R1 is phenyl or pyridinyl, each optionally substituted with Q and up to 3 substituents independently selected from R2; each R2 is independently halogen, cyano, SF5, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio or C1-C4 haloalkylthio; and Q is phenyl or pyridinyl, each optionally substituted with up to 5 substituents independently selected from the group consisting of halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy and C1-C4 haloalkoxy. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.

Abstract: The present invention relates to host cells having modified lipid-linked oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an engineered host cell which can be used to express and target any desirable gene(s) involved in glycosylation. Host cells with modified lipid-linked oligosaccharides are created or selected. N-glycans made in the engineered host cells have a GlcNAcMan3GlcNAc2 core structure which may then be modified further by heterologous expression of one or more enzymes, e.g., glycosyl-transferases, sugar transporters and mannosidases, to yield human-like glycoproteins. For the production of therapeutic proteins, this method may be adapted to engineer cell lines in which any desired glycosylation structure may be obtained.

Abstract: The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (A) Fluopyram and (B) one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

Abstract: The present invention is directed to the examination of the pattern of immunodominant T cell epitopes in the E6 protein of Human Papilloma virus and its further characterization in terms of its amino acid sequence and Human Leukocyte Antigen restriction. These epitopes are identified based on their ability to induce specific T cell responses and therefore, are important as sources of antigens for immunotherapies to treat cervical and other cancers. The present invention contemplates identifying a number of similar epitopes restricted by a wide variety of Human Leukocyte Antigen types so that they can be used together to develop preventative or therapeutic vaccines, which can be used for the general human population. The present invention also contemplates using E6 peptides of Human Papilloma virus as a diagnosis method to predict the probability of developing persistent cervical neoplasia in an individual.

Abstract: Treatment of plants against infection by oomycetes. The invention refers to a new strain of Phoma useful for manufacturing a plant-care composition intended to treat plants against phytopathogenic oomycetes. This new strain was deposited on Feb. 25, 2010 with the Collection Nationale de Cultures de Microorganismes of the Institut Pasteur in Paris, France under the CNCM number I-4278.

Abstract: This invention provides a composition comprising a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure, and an effective amount of at least one fungicide.

Abstract: Coccidioidomycosis (Valley Fever) is currently diagnosed by relying on infected individuals (humans, dogs, etc.) to generate antibodies against the fungus. Since the immune response against Valley Fever can be delayed or absent in many cases, methods that detect a polypeptide or peptide component of the Coccidioides sp. fungus in a bodily fluid such as blood are provided.