Platelet Patents (Class 424/93.72)
  • Patent number: 11425905
    Abstract: An antimicrobial preventive netting is disclosed that includes one or more photosensitizers that are capable of generating a cloud of singlet oxygen on each surface and openings through the netting in response to incident light. A depth of the singlet oxygen cloud may be less than 0.7 centimeters from a netting surface. The netting may be supported by screens, enclosures or headgear. The netting can be made by dipping or soaking the netting in a solution of one or more photosensitizers.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: August 30, 2022
    Assignees: University of Washington, Seattle Children's Hospital
    Inventors: James Chen, Tanner Clark, Thomas Lendvay
  • Patent number: 11224616
    Abstract: A wound or tissue healing composition and related treatment methods are provided. The wound or tissue healing composition includes an effective amount of a platelet-rich plasma aseptically recovered from umbilical cord and an effective amount of a human birth tissue material composition.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: January 18, 2022
    Assignee: BIODLOGICS, LLC
    Inventor: Timothy R. Brahm
  • Patent number: 11191781
    Abstract: The present disclosure relates to a composition including non-autologous plasma or serum and a polymer; method of treating ophthalmic diseases (e.g., dry eye syndrome) or moisturizing and/or repairing non-keratinized surfaces including non-healing wounds with a composition including non-autologous plasma or serum and a polymer; and a therapeutic agent delivery device for delivery of the composition to the eye or a non-keratinized surface of a subject.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: December 7, 2021
    Assignee: Eye Care International, LLC
    Inventors: Matthew B. Dowling, Steven E. Lazar, Helga M. Gentile
  • Patent number: 10851343
    Abstract: The present invention provides a method for producing purified platelets from a culture of megakaryocytes, comprising a first centrifugal separation step of centrifugally separating the culture at a centrifugal force of 150×g to 550×g, and a second centrifugal separation step of centrifugally separating, at a centrifugal force of 600×g to 4000×g, a liquid component recovered in the first centrifugal separation step.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 1, 2020
    Assignee: Megakaryon Corporation
    Inventors: Hidenori Hirose, Michiko Ueda
  • Patent number: 10772824
    Abstract: This invention relates to method of improving the appearance of skin or hair. In particular, it relates to cosmetic products such as creams and serums comprising a subject's own platelet rich plasma (PRP). The invention also relates to kits that allow the user to apply the cosmetic products daily for several days.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: September 15, 2020
    Assignee: PPLUS SKIN CARE LIMITED
    Inventor: Mitra Najafi
  • Patent number: 10725041
    Abstract: Methods of creating cells expressing specific platelet alloantigens by combining gene editing techniques and cell culture differentiation or expansion techniques employing pluripotent cells, including the steps of transfecting pluripotent cells with a plasmid encoding one or more guide RNAs targeting within a platelet alloantigen target locus and a nuclease in the presence of an HDR repair oligo and culturing the resulting cells to expand their numbers or to create a differentiated cell type of interest.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: July 28, 2020
    Assignee: VERSITI BLOOD RESEARCH INSTITUTE FOUNDATION, INC.
    Inventors: Peter Jay Newman, Sridhar Rao, Nanyan Zhang, Huiying Zhi
  • Patent number: 10632063
    Abstract: This invention relates to kits that allow the user to apply cosmetic products such as creams and serums to be mixed with a subject's own platelet rich plasma (PRP) and applied to the skin for several days.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 28, 2020
    Assignee: PPLUS SKIN CARE LIMITED
    Inventor: Mitra Najafi
  • Patent number: 10617742
    Abstract: Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries e.g., preventing transfusion-related acute lung injury (TRALI), by treating blood transfusion products with an anti-Neutrophil Extracellular Trap (NET) compound.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: April 14, 2020
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Denisa D. Wagner, Tobias A. Fuchs, Simon De Meyer, Kimberly Martinod, Alexander Brill, Grace M. Thomas
  • Patent number: 10596197
    Abstract: Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, acute lung injury, lung allograft rejection (acute or chronic), pulmonary fibrosis. Described herein is the development of red blood cell membrane-derived microparticles (RBC MPs), which are depleted of hemoglobin (Hb) and express phosphatidylserine on their surface, for the treatment of lung disease. Administration of RBC MPs to the lung via inhalation promotes the production of immunoregulatory cytokines (such as IL-10), and reduces inflammation and injury in the lung.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: March 24, 2020
    Assignee: University of Pittburgh—Of the Commonwealth System of Higher Education
    Inventors: Janet S. Lee, Timothy E. Corcoran, Valerian Kagan
  • Patent number: 10561783
    Abstract: A centrifugal separating assembly for separating a fluid biological product into discrete components by centrifugation is disclosed. The assembly includes a first container defining a first cavity adapted to receive a human biological product, the first container having a circular upper wall, a cylindrical sidewall, and a concave shaped bottom wall. The assembly further includes a second container defining a second cavity adapted to receive discrete components. The first container is positioned within the second container, and moveable to a selected position within the second container so that a layer of a fluid biological product will be at a desired location after centrifugation.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: February 18, 2020
    Inventors: Ziad Hamandi, Shawn R. Browning
  • Patent number: 10538738
    Abstract: Applications in transfusion medicine requiring platelets, and hematopoietic stem-cell transplantations require either platelets or enhancement of in vivo platelet biogenesis. Gene therapy applications of hematopoietic stem and progenitor cells (HSPCs) require effective and specific modification of HSPCs by DNA, RNA or other biological molecules. Here we disclose methods for the generation, and modification of megakaryocytic microparticles (MkMPs) or microvesicles, that can be used in the aforementioned transfusion and transplantation medicine applications and in gene therapy applications involving hematopoietic stem cells. The biological effects of modified or unmodified MkMPs have never been previously disclosed and thus, this invention claims all biological applications of MkMPs in in vivo therapeutic applications or ex vivo applications to produce various cells and cell parts, modify various target cells or deliver molecules including drugs to HSPCs and related cells.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: January 21, 2020
    Inventors: Eleftherios Papoutsakis, Chen-Yuan Kao, Jinlin Jiang
  • Patent number: 10420802
    Abstract: Disclosed herein is a method of preparing a subject's cells for topical treatment of a subject in need. Also provided is a topical formulation and methods of treating a subject suffering a skin disorder and pain using the topical formulation. Also disclosed herein are devices and systems for micronizing an aspirate in preparation of such a topical formulation.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: September 24, 2019
    Assignee: AESTHETICS BIOMEDICAL, INC.
    Inventor: Farhan Taghizadeh
  • Patent number: 10098340
    Abstract: Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22° C. and 37° C.; lowering the temperature in the container to between 0.1° C. and 10° C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22° C.-37° C. By performing these steps, the cells undergo less apoptosis than a reference.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: October 16, 2018
    Assignee: Rich Technologies Holding Company, LLC
    Inventors: William E. Grieshober, Jr., James S. Jones, Semyon Kogan, Ilya Ilyin, Natella I. Enukashvily, Yana A. Filkina, Alexander N. Shumeev, Stanislav Kolchanov
  • Patent number: 10016459
    Abstract: A platelet-rich plasma composed of aseptically recovered umbilical cord blood is provided, as well as uses thereof.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: July 10, 2018
    Assignee: BioDlogics, LLC
    Inventor: Timothy B. Brahm
  • Publication number: 20150147397
    Abstract: This invention is directed to aragonite and calcite hydrogel biomatrices, optionally seeded with precursor cells and uses thereof in tissue engineering, regeneration and repair, including in inducing or enhancing bone formation, cartilage formation or a combination thereof in a subject, and kits related thereto.
    Type: Application
    Filed: April 29, 2013
    Publication date: May 28, 2015
    Inventor: Nir Altschuler
  • Publication number: 20150148901
    Abstract: Described herein are systems and methods for soft tissue reconstruction and augmentation using a platelet-rich fibrin matrix. In one embodiment the system of the present invention includes a blood collection apparatus capable of drawing blood from a patient, a matrix preparation container configured to hold a patient's blood while the blood is separated and coagulated to form a platelet-rich fibrin matrix therein, and a matrix delivery device configured to receive the matrix preparation container therein and compress and force the platelet-rich fibrin matrix out of the matrix preparation container and into the patient. In another embodiment the invention described herein is a method in which blood is drawn from a patient and separated and coagulated to form a platelet-rich fibrin matrix. The platelet-rich fibrin matrix is implanted into a patient at the site of a tissue defect or where tissue augmentation is desired.
    Type: Application
    Filed: March 11, 2014
    Publication date: May 28, 2015
    Inventor: Anthony Patrick Napolitano
  • Publication number: 20150125436
    Abstract: The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 7, 2015
    Inventor: ANTOINE TURZI
  • Publication number: 20150118210
    Abstract: The present invention provides a composition for enhancing cell engraftment and homing properties, containing platelet-rich plasma (PRP) as an active ingredient. The present invention provides a method for improving cell engraftment and homing properties, comprising the step of treating in vitro isolated cells with a composition containing PRP as an active ingredient. According to the present invention, when a cell to be transplanted or a region to which cells are transplanted is treated with PRP, or a cell to be transplanted is mixed with PRP, transplantation to an in vivo region is carried out, thereby increasing cell engraftment in a transplanted region and increasing cell homing from a transplanted region to a damaged region.
    Type: Application
    Filed: May 28, 2013
    Publication date: April 30, 2015
    Applicant: SNU R&DB FOUNDATION
    Inventors: Hyun Chul Jo, Hyang Kim
  • Publication number: 20150104436
    Abstract: Preactivated and disaggregated shape-changed platelets, fixed shape-changed platelets, and a pharmaceutical composition thereof are used for treating acute and emergent inflammatory disease in a dosage of 1×106 to 1×108. Activated platelets release and transfer adhesion factors to the surface of platelet cells, and trap stromal vascularity inflammatory cells from inflammated and damaged place, and the stromal vascularity inflammatory cells are eliminated through the circulatory system to alleviate inflammation. The fixed shape-changed platelets are able to alleviate inflammation and sustainable for longer storage duration.
    Type: Application
    Filed: October 13, 2013
    Publication date: April 16, 2015
    Applicant: CHANG GUNG MEDICAL FOUNDATION, LINKOU BRANCH
    Inventors: Yuan-Ji Day, Li-Man Hung, Shiang-Suo Huang, Hsiang-Ruei Liao, Chiou-Mei Lee, Jiin-Tarng Liou, Fu-Chao Liu, Chih-Chieh Mao, Polung Yang
  • Publication number: 20150093367
    Abstract: A system and method are provided that use the meridian flow defined in traditional Chinese medicine to target specific regions of the body to treat certain health conditions. A cellular mixture is injected into the body via an acupoint on a particular meridian in order to deliver the mixture to an organ or body region associated with the particular meridian. The cellular mixture can be a stem cell/PRP mixture.
    Type: Application
    Filed: September 29, 2014
    Publication date: April 2, 2015
    Inventor: BILL AKPINAR
  • Patent number: 8993321
    Abstract: A blood storage container suitable for quick and efficient production of a large amount of serum while ensuring high safety, and a method of separating blood and a regenerative medical process using the same are provided. A blood component separation storage apparatus is provided for separating a plurality of blood components of blood so as to be stored therein. The blood component separation storage apparatus includes a blood reservoir for holding the blood and a component storage part connected to the blood reservoir aseptically and in an air-tight manner. The blood reservoir contains an anticoagulant which suppresses coagulation of the blood. The blood reservoir has a serum producing function to remove coagulation factors from the blood to an extent enabling use in practical applications as a serum, and the component storage part stores each blood component generated by separation of the blood in the blood reservoir.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: March 31, 2015
    Assignee: JMS Co., Ltd.
    Inventors: Koji Suzuki, Junya Fujii, Mari Takabatake, Seishin Tanaka, Ken Kondo
  • Publication number: 20150071893
    Abstract: Provided is a therapeutic preparation including a substance including ozone and a proteic substance. Also provided are methods of treating a disorder in a bovid, including administering to a subject in need thereof, a therapeutically effective amount of the therapeutic preparation.
    Type: Application
    Filed: March 5, 2013
    Publication date: March 12, 2015
    Inventors: Andrea BIGNOTTI, Chiara TURELLI
  • Patent number: 8968391
    Abstract: Methods for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed are application of cell growth promoting compositions such as, but not limited to, autologous platelet gel compositions directly to treatment sites during or after stent graft implantation.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: March 3, 2015
    Assignee: Medtronic Vascular, Inc.
    Inventors: Dennis Brooks, Jack Chu, Scott Doig, Trevor Huang, Tessy Kanayinkal
  • Publication number: 20150050257
    Abstract: A fibrosis-causing agent is highly effective in the fibrosis of tissues. The fibrosis-causing agent contains a fibrosis inducer and a fibrosis promoter. A fibrosis-causing agent dosage form and a method of administering the fibrosis-causing agent is also disclosed.
    Type: Application
    Filed: August 19, 2014
    Publication date: February 19, 2015
    Inventors: SUGURU HATA, YUICHI TADA, AYAKA AKUTAGAWA
  • Publication number: 20150030578
    Abstract: A method and kit to produce activated autologous platelet rich and platelet poor plasma (AAPRPP) and methods of use to treat pain. The method to produce AAPRPP generally comprising (1) obtaining whole blood from patient; (2) centrifuging whole blood in a collection tube; (3) extracting platelet rich and platelet poor plasma mixture from collection tube; and (4) transferring platelet rich and platelet poor plasma mixture to an activation tube containing at least one platelet aggregator and at least one platelet activator to obtain a resulting platelet concentration. The method to treat pain generally comprising producing AAPRPP and extracting contents of activation tube into a standard syringe then injecting AAPRPP at or near the nerve group responsible for the affected anatomical area.
    Type: Application
    Filed: July 23, 2014
    Publication date: January 29, 2015
    Inventors: Bill J. Releford, JR., James Hays, John Simmonds
  • Publication number: 20150023939
    Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
    Type: Application
    Filed: October 9, 2014
    Publication date: January 22, 2015
    Inventor: Jennifer E. WOODELL-MAY
  • Patent number: 8936784
    Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: January 20, 2015
    Assignee: Poly-Med, Inc.
    Inventors: Joel Corbett, Jason Olbrich, Joanne E. Shalaby
  • Publication number: 20150018754
    Abstract: A device to prepare and deliver a bioactive substance such as stem cells, platelet rich plasma, and/or other bioactive compositions. The device can utilize a hallow interior or cavity to deliver bioactive substances during a surgical procedure or to an area of cartilage defect or cartilage disorder. The treated tissues can include connective tissue, cardiac muscle or tissue, spinal tissue, internal organs, skin tissue, brain tissue, vascular tissue, ocular, ear, nose, throat tissue, and/or other hematologic, endocrine or integumentary tissue.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Inventor: Allan Mishra
  • Publication number: 20150017145
    Abstract: A method of treating a natural soft skeletal tissue injury in a patient the method comprising administering to the patient a composition of mesenchymal stem cells in liquid suspension enriched compared to the natural source of said cells, or tenocytes derived therefrom. The method is particularly suited to the regeneration of tendons in competitive mammals, such as the superficial digital flexor tendon of the horse.
    Type: Application
    Filed: September 16, 2014
    Publication date: January 15, 2015
    Applicant: RECELLERATE, INC.
    Inventors: Roger Kenneth Whealands Smith, Kenneth Gregory McGarrell, Allen Edward Goodship, Gordon William Blunn
  • Publication number: 20150010517
    Abstract: An apparatus for the preparation of cells for implantation into a living body is disclosed. The apparatus comprises a vessel substantially impermeable to gaseous oxygen; and fluid within said vessel, the fluid having a maximal dissolved oxygen capacity substantially equivalent to normal saline yet having a hypoxic oxygen concentration between about 0% to about 5% of said maximal dissolved oxygen capacity. The bag oxygen concentration level remains low when the apparatus is stored at 22°-25° C. in normal atmospheric conditions for a period of at least 30 days. The present invention simplifies the process of achieving donor cell hypoxic preconditioning for cell implantation, and may be used to bathe said cells to be transplanted for a sufficient time to activate the hypoxic metabolic pathway.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Inventor: John R. Chapman
  • Patent number: 8927288
    Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: January 6, 2015
    Assignee: Vanderbilt University
    Inventors: Dennis E. Hallahan, Raymond Mernaugh
  • Publication number: 20140369984
    Abstract: The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and/or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and/or joint surgery.
    Type: Application
    Filed: February 1, 2013
    Publication date: December 18, 2014
    Applicants: Children's Medical Center Corporation, Rhode Island Hospital
    Inventors: Martha M. Murray, Braden C. Fleming
  • Patent number: 8911789
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: December 16, 2014
    Assignees: Carnegie Mellon University, Allegheny-Singer Research Institute, Carmell Therapeutics Corporation
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Publication number: 20140363412
    Abstract: Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 11, 2014
    Inventors: Vasile Bogdan Neculaes, Antonio Caiafa, Brian Duh-Lan Lee, Nicole Evelyn LaPlante, Andrew Soliz Torres, Allen Lawrence Garner
  • Publication number: 20140348810
    Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Applicant: POLY-MED, INC.
    Inventor: Shalaby W. Shalaby
  • Publication number: 20140341874
    Abstract: The invention relates to a dextran-based tissuelette comprising platelet-rich plasma lysate (PRPL), which can be used for tissue repair. In particular, the tissuelette of the present invention can be adapted to display properties similar to natural cartilage, while having increased chondrocyte-attraction. Also, it has a tunable biostability that allows for degradation of the tissuelette material during natural tissue regeneration. In addition, the tissuelette displays full and covalent integration with the surrounding tissue when prepared directly at the site requiring tissue repair. The tissuelette of the present invention is primarily meant for use in cartilage repair, in particular cartilage repair upon degradation by osteoarthritis.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 20, 2014
    Applicant: University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA)
    Inventors: Liliana Sofia Moreira Teixeira, Pieter Jelle Dijkstra, Hermanus Bernardus Johannes Karperien
  • Publication number: 20140322289
    Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 30, 2014
    Inventors: John Daniel, Randall Spencer, John Russo, Robert Tofe
  • Publication number: 20140294985
    Abstract: The invention provides injectable, biofunctional agent-containing calcium phosphate cement bone pastes for bone tissue engineering, and methods of making and using the same.
    Type: Application
    Filed: October 12, 2012
    Publication date: October 2, 2014
    Applicant: UNIVERSITY OF MARYLAND,BALTIMORE
    Inventor: Huakun Xu
  • Publication number: 20140294794
    Abstract: The present invention relates to a platelet subpopulation with high binding capacity to recombinant activated factor VII (rFVIIa), and its use for the treatment of bleeding disorders and for determining whether a subject is a candidate for treatment with rFVIIa.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 2, 2014
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Ernst Böhm, Michael Dockal, Andrea Sedivy
  • Publication number: 20140286962
    Abstract: The disclosure relates to methods for detecting PNH Type II cell populations in biological samples as well as methods for determining whether a patient is at an increased risk for developing thrombocytopenia or thrombosis based on the percentage of PNH Type II cells in the patient's blood. The disclosure also features reagents and conjugates for use in the methods.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 25, 2014
    Applicant: ALEXION PHARMACEUTICALS, INC.
    Inventors: Mayur MOVALIA, Andrea ILLINGWORTH, Susan FAAS MCKNIGHT, Russell P. ROTHER
  • Publication number: 20140271589
    Abstract: Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: BIOMET BIOLOGICS, LLC
    Inventors: Andrea MATUSKA, Krista O'SHAUGHNESSEY, Jennifer E. WOODELL-MAY
  • Publication number: 20140271587
    Abstract: Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cBMA), optionally combining the protein solution and cBMA to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof. The present methods, compositions and devices are useful for treating COPD and the progression of COPD.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: BIOMET BIOLOGICS, LLC
    Inventors: Matthew D. LANDRIGAN, Krista O'SHAUGHNESSEY, Jennifer E. WOODELL-MAY
  • Publication number: 20140271590
    Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.
    Type: Application
    Filed: December 21, 2013
    Publication date: September 18, 2014
    Applicant: Advanced Cell Technology, Inc.
    Inventors: Qiang Feng, Shi-Jiang Lu, Robert P. Lanza
  • Patent number: 8835104
    Abstract: Synthetic storage media are disclosed for use in the processing and the storing of platelets. The storage media includes a platelet storage solution and less than 20 percent plasma to preserve platelet function after at least 7 days of storage.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: September 16, 2014
    Assignee: Fenwal, Inc.
    Inventors: Véronique Mayaudon, Jean-Marc Payrat
  • Patent number: 8821858
    Abstract: This invention relates to an improved Lyophilized platelet rich plasma used to make a platelet gel wound healant, and methods of preparation and use thereof for healing wounds are disclosed. The improved wound healant comprises therapeutically effective amounts of activated growth factors, platelet ghost, plasma (know as the plasma back bone), white blood cells with optional none, one or more additional anti-oxidant such as vitamin A and/or C and/or E, and/or none one or more antibiotics and/or GHK-Cu (produced by ProCyte Inc.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: September 2, 2014
    Assignee: GW IP, LLC
    Inventors: James Bennie Gandy, Mackie J. Walker, Jr.
  • Publication number: 20140242054
    Abstract: Described herein are methods and compositions for the treatment of respiratory diseases such as, for example, exercise induced pulmonary hemorrhage. The methods include the use of compositions comprising platelet enriched plasma, for example, platelet rich plasma and/or platelet poor plasma, for treatment of respiratory diseases in humans and animals, in particular, equines, by administration to the respiratory system.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: VETGEL TECHNOLOGIES
    Inventor: Richard Gold
  • Publication number: 20140227240
    Abstract: Compositions and processes for the effective and efficient regeneration of spinal discs are provided. These compositions contain stem cells, donor cells, and platelet plasma compositions. By using these compositions, there is an increased likelihood of acceptance and proper cell differentiation.
    Type: Application
    Filed: February 8, 2013
    Publication date: August 14, 2014
    Applicant: Laser Spine Institute, LLC
    Inventor: Mark Flood
  • Publication number: 20140227241
    Abstract: The invention provides for a method of preparing an isolated serum fraction of platelet rich fibrin (PRF), comprising the steps of a. providing platelet rich plasma (PRP) without the addition of an anticoagulant; b. clotting the PRP to obtain a coagel of PRF; and c. separating the coagel to isolate the serum fraction which comprises an activated platelet releasate; and further provides for the isolated serum fraction obtained by such method, and its medical use.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 14, 2014
    Applicant: LACERTA TECHNOLOGIES INC.
    Inventors: Zsombor LACZA, GABRIELLA VACZ
  • Patent number: 8802083
    Abstract: The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising poly-?-1?4-N-acetylglucosamine polymers and stored platelets and their use for promoting wound healing and achieving hemostasis.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: August 12, 2014
    Assignee: Marine Polymer Technologies, Inc.
    Inventors: John N. Vournakis, Sergio Finkielsztein
  • Publication number: 20140220085
    Abstract: In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.
    Type: Application
    Filed: April 11, 2014
    Publication date: August 7, 2014
    Applicant: Industrial Technology Research Institute
    Inventors: Pei-Yi TSAI, Yi-Hung WEN, Zhi-Jie HUANG, Pei-Shan LI, Hsin-Hsin SHEN, Yi-Hung LIN, Chih-Hung CHEN