Multienzyme Complexes Or Mixtures Of Enzymes Patents (Class 424/94.2)
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Publication number: 20090053188Abstract: The present invention relates to a method for substantially preventing a reduction in feed intake in an animal which occurs when said animal is administered an antibiotic, the method comprising administering to an animal in need of prevention of a reduction in feed intake, increasing doses of a composition comprising one or more antibiotics. The present invention also relates to a method for treating laminitis and fermentative acidosis in an animal in need of said treatment, the method comprising administering increasing doses of a composition comprising one or more antibiotics. The present invention further relates to a method for treating equine grass sickness and pulpy kidney in an animal in need of said treatment, the method comprising administering increasing doses of a composition comprising one or more antibiotics.Type: ApplicationFiled: December 15, 2006Publication date: February 26, 2009Inventors: James Baber Rowe, Christopher William Rowe
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Publication number: 20090047266Abstract: The pharmaceutical use of lipases related to a variant of the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 1, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have an improved efficacy in vivo, are stable against protease-degradation, and/or are stable in the presence of bile salts.Type: ApplicationFiled: June 16, 2006Publication date: February 19, 2009Applicants: Novozymes A/S, Solvay Pharmaceuticals Hans-BoecklerInventors: Allan Svendsen, Peter Colin Gregory, Kim Borch
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Publication number: 20090010910Abstract: The invention relates to compositions for debriding damaged skin comprising at least one enzymatic debriding agent and at least one antiseptic compound comprising heavy metal ions. The present invention further relates to kit and methods for topical debridement of damaged skin, particularly of burned skin.Type: ApplicationFiled: July 13, 2005Publication date: January 8, 2009Applicant: MEDIWOUND LTD.Inventors: Amir Toren, Lior Rosenberg, Marian Gorecki
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Publication number: 20080317726Abstract: The pharmaceutical use of proteases related to amino acids 1-274 of SEQ ID NO: 2, the serine protease derived from Bacillus licheniformis, which is also designated subtilisin Carlsberg, optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.Type: ApplicationFiled: June 16, 2006Publication date: December 25, 2008Applicants: Novozymes A/S, Solvay Pharmaceuticals GmbHInventors: Allan Svendsen, Claus Crone Fuglsang, Peter Colin Gregory
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Publication number: 20080299102Abstract: Disclosed and claimed are novel BACE proteins, crystal structures thereof, nucleic acid molecules therefor, and methods for making and using and uses of the same, especially for ascertaining inhibitors of BACE; and thus, disclosed and claimed too are inhibitors of BACE and methods of making and using the same.Type: ApplicationFiled: January 21, 2004Publication date: December 4, 2008Inventors: Jeff Yon, Anne Cleasby, Wouter David Bruinzeel, Stefan Leo Masure, Ian Tickle, Andrew Sharff
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Publication number: 20080299185Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: ApplicationFiled: February 20, 2008Publication date: December 4, 2008Inventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
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Publication number: 20080279839Abstract: The invention provides compositions and methods for treating pancreatic enzyme insufficiency, such as the pancreatic enzyme insufficiency associated with cystic fibrosis. The invention also provides compositions comprising lipase from Candida cylindracea, alone or in combination with amylase or amyloglucosidase, protease and/or lactase. Furthermore, the invention discloses methods for treating pancreatic enzyme insufficiency comprising administering compositions to patients in need thereof.Type: ApplicationFiled: October 31, 2006Publication date: November 13, 2008Inventors: Christopher Schuler, Edward F. Schuler
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Publication number: 20080279953Abstract: Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.Type: ApplicationFiled: February 20, 2008Publication date: November 13, 2008Inventors: Giovanni Ortenzi, Marco Marconi, Luigi Mapelli
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Patent number: 7429377Abstract: A pharmaceutical composition having thrombolytic, anti-inflammatory and cytoprotective properties is described. The composition contains active proteases attached to a gel or to a mixture of a gel with a water-soluble polymer, said attachment being achieved with the help of radiation, preferably with the help of gamma-radiation or a flow of accelerated electrons. As the proteases the composition contains proteases which are stable at a temperature of up to 70° C., preferably at 30-40° C., for instance such as subtilysine, trypsin, chemotrypsin, papain or streptokinase. The gel is preferably polyethylene glycol gel, dextran gel, or polyglycane gel, and the water-soluble polymer is polyethylene glycol, polyvinyl alcohol, dextran or polyglycane. The method of preparing said composition and its use are also disclosed. The composition has a broad range of application, and can be used in cardiology, nephrology, surgery, rheumatology, gynecology and gastroenterology.Type: GrantFiled: December 24, 2002Date of Patent: September 30, 2008Assignee: Zakrytoe Aktsionernoe Obschestvo “Aksis”Inventors: Andrei Vladimirovich Artamonov, Evgeny Ivanovich Vereschagin, Oleg Vitalievich Grishin, Alexandr Vasilievich Troitsky
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Publication number: 20080226568Abstract: A synergistic preservative system having an oil-miscible glycol and an enzymatic composition. The synergistic preservative system demonstrates enhanced anti-fungal, anti-bacterial, and anti-microbial efficacy and is free of formaldehyde donors, parabens, ethanols, and isothiazolinones.Type: ApplicationFiled: March 13, 2007Publication date: September 18, 2008Inventors: Ellen Rozsa, Grace Riccardi, Ben Ramirez
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Publication number: 20080219964Abstract: Methods for increasing energy in men and women include ingesting internally, twice a day, products that include, for women, multivitamins, multiminerals, high-calcium bone support products, high-ORAC super food products, and enzymes, and, for men, multivitamins, multiminerals, prostate support products, high-ORAC super food products, and enzymes.Type: ApplicationFiled: May 13, 2008Publication date: September 11, 2008Inventors: Candace R. Keefe, Michele Arth
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Publication number: 20080213320Abstract: The present invention provides compositions for treatment of gastro-esophageal reflux disorders. The compositions include at least two of the following: (i) one or more digestive enzymes; (ii) one or more probiotics; and (iii) stevia. Also provided are processes for preparing the compositions useful for treatment of gastro-esophageal reflux disorders, and methods of treating subjects against gastro-esophageal reflux disorders, which include administering to a subject a therapeutically effective amount of the compositions of the present invention.Type: ApplicationFiled: July 3, 2007Publication date: September 4, 2008Inventors: Mayer Eisenstein, Jeremy B. Eisenstein
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Publication number: 20080199448Abstract: An orally administered composition for improving food absorption and digestion contains therapeutically effective dosages of digestive enzymes and L-glutamine as active ingredients. The digestive enzymes include at least one each of a lipase, a protease, and an amylase, and at least a portion of each of these enzymes is enteric coated.Type: ApplicationFiled: February 15, 2008Publication date: August 21, 2008Inventors: Mairi R. Ross, Yoon Mo Kang
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Patent number: 7393528Abstract: Methods for exterminating pests using compositions comprising at least one protease enzyme. A detergent component may also be utilized in such compositions.Type: GrantFiled: October 16, 2003Date of Patent: July 1, 2008Inventor: Stephen L. Tvedten
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Publication number: 20080152637Abstract: A method for treating a Parkinson's patient with digestive/pancreatic enzymes involves administering an effective amount of digestive/pancreatic enzymes to an individual having the disorder in order to improve a symptom of the disorder. In addition, a method is provided for determining whether an individual has, or may develop, Parkinson's disease or related dysautonomic disorders and for determining whether an individual will benefit from the administration of pancreatic/digestive enzymes to treat the dysautonomic disorder.Type: ApplicationFiled: March 11, 2008Publication date: June 26, 2008Inventor: Joan M. Fallon
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Publication number: 20080152706Abstract: The invention describes compositions, including soft gelatin capsules, that include dihydrolipoic acid and the reduced form of coenzyme Qn wherein the dihydrolipoic acid acts as a reducing agent for the coenzyme Qn and also, optionally, as a solvent.Type: ApplicationFiled: August 23, 2007Publication date: June 26, 2008Inventors: Jingang Shi, Chenghai Zhao, Wenxian Pan, Yunlong Feng
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Publication number: 20080124314Abstract: Novel polypeptides or derivatives comprising cdk2 binding site are disclosed. The novel polypeptides or derivatives have growth suppressive activity. Nucleic acids encoding those polypeptides are also disclosed. The polypeptides identified herein are also useful in methods for treating or preventing cancer. The treatment methods comprise administration of the polypeptide to the patient. The methods also comprise contacting the sample with the above-described polypeptide or derivative, wherein the polypeptide or derivative also comprises a covalently attached detectable moiety, then determining whether the polypeptide or derivative is binding cdk2 from the sample.Type: ApplicationFiled: October 17, 2006Publication date: May 29, 2008Inventor: Antonio Giordano
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Publication number: 20080112943Abstract: Modified biosynthetic polypeptide fusion inhibitors, methods for manufacturing, and uses thereof are provided.Type: ApplicationFiled: October 30, 2007Publication date: May 15, 2008Applicant: AMBRX, INC.Inventors: Roberto MARIANI, Bruce E. KIMMEL
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Patent number: 7361344Abstract: A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of removal of the arterial obstruction.Type: GrantFiled: December 28, 2004Date of Patent: April 22, 2008Assignee: Genentech, Inc.Inventors: Martin M. Bednar, Linda Gross, legal representative, G. Roger Thomas, Cordell E. Gross
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Patent number: 7354749Abstract: A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors.Type: GrantFiled: May 20, 2002Date of Patent: April 8, 2008Assignee: The University LeedsInventors: John Fisher, Catherine Booth, Eileen Ingham
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Publication number: 20080044397Abstract: Compositions of human proteins, methods and regimens for reducing the occurrence and growth of skin cancer, including melanoma, are provided. The methods include steps of administering topically on the skin tumor or a skin cancer-free area of compositions containing therapeutically effective amounts of human alkaline phosphatase, transferrin and ?1-antitrypsin. In some embodiments, the composition is topically administered and includes all three proteins. Alkaline phosphatase, alone or in combination with transferrin and ?1-antitrypsin can also be administered by injection with or without simultaneous or sequential topical administration. Administration of compositions topically and/or by injection can be part of a more complex cancer therapy including chemotherapy, radiotherapy, surgery, and electrochemotherapy.Type: ApplicationFiled: August 21, 2006Publication date: February 21, 2008Applicant: ESSENTIAL SKINCARE, LLCInventor: Zotan Kiss
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Publication number: 20080019956Abstract: Described herein is a composition for removing biofilm from surfaces. The composition is an enzyme mixture having at least three enzymes and resulting in the removal of at least 40% biofilm from the surface.Type: ApplicationFiled: July 24, 2006Publication date: January 24, 2008Inventor: Manoj Kumar
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Publication number: 20070212358Abstract: A composition comprises plasmin or an enzymatically equivalent derivative thereof and an inhibitor of at least an enzyme that is activatable, directly or indirectly, by plasmin or one of its enzymatically equivalent derivatives. The composition can be used to effect or induce a controlled posterior vitreous detachment (“PVD”) to prevent, treat, or ameliorate a potential complication of a pathological ocular condition. Such a composition can be administered intravitreally.Type: ApplicationFiled: February 23, 2007Publication date: September 13, 2007Inventor: Stephen P. Bartels
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Patent number: 7255858Abstract: The present invention is directed to a composition and method for enhancing the complement-mediated cytotoxicity of therapeutic antibodies for their target cells (i.e. those cells displaying the target epitope). More particularly the present invention enhances the efficacy of such therapies by providing a supplemental source of complement.Type: GrantFiled: August 9, 2002Date of Patent: August 14, 2007Assignee: University of Virginia Patent FoundationInventors: Ronald P. Taylor, Margaret A. Lindorfer, Michael D. Solga, Adam Kennedy
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Patent number: 7198785Abstract: The present invention generally relates to the treatment of uremic toxins in vivo using uremic toxin-treating enzymes, and/or cells capable of producing uremic toxin-treating enzymes or otherwise reacting with uremic toxins. Non-limiting examples of cases where the treatment of uremic toxins is desired include renal disease or dysfunction, gout, subjects receiving chemotherapy, or the like. In one aspect, the treatment includes an oral delivery composition able to reduce the blood concentration of one or more non-protein nitrogen compounds in vivo. The composition, in some cases, may comprise one, two, or more uremic toxin-treating enzymes, such as urease, uricase or creatininase. The oral delivery composition may be able to deliver the uremic toxin-treating enzymes, substantially undigested, to the intestines, where the enzymes can interact with uremic toxins transported to the intestines from the bloodstream.Type: GrantFiled: December 9, 2003Date of Patent: April 3, 2007Assignee: Brown UniversityInventors: Jill A. O'Loughlin, Jan Markus Bruder, Michael J. Lysaght
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Patent number: 7166281Abstract: A pharmaceutical composition for relieving the itch, pain, and swelling resulting from insect bites and stings, and methods for producing and using the composition. The method preferably comprises topically applying to the affected area the composition which contains an abrasive ingredient and an anti-itch enzyme, both of which are dispersed in a carrier containing effective amounts of emulsifiers, and/or dispersants and may take the form of a powder, liquid, or paste. The final pharmaceutical composition is preferably made in the form of a cream or lotion so that it can be rubbed directly on the skin at the affected site. The pharmaceutical composition for relieving the itch, pain, and swelling resulting from insect bites and stings disclosed herein may also contain an anesthetic and/or antibiotic.Type: GrantFiled: April 30, 2001Date of Patent: January 23, 2007Assignee: American Natural Technology Sciences, Inc.Inventor: Patrick Kennedy
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Patent number: 7153504Abstract: The present invention provides stabilized pancreas products useful, for example, as an animal feed additives. The invention also provides for feed additives and feed rations comprising a stabilized pancreas product. Further, the invention provides for methods of making stabilized pancreas products. The present invention also provides for methods of supplementing an animal feed utilizing stabilized pancreas products.Type: GrantFiled: July 30, 2004Date of Patent: December 26, 2006Assignee: CAN Technologies, Inc.Inventors: Andrew J. La Follette, Jennifer L.G. van de Ligt, Christiaan P.A. van de Ligt, Mark D. Newcomb, W. Michael Craig, Kevin Touchette
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Patent number: 7150985Abstract: The inventions relate to the field of medicine, veterinary and biotechnology and may be used for production of a drug for medical and veterinary purposes. A bacteriolytic complex, produced by the bacterium Lysobacter sp. XL1, has been proposed, which contains bacteriolytic enzymes (muramidase, muramoylalanineamidase, endopeptidase, a bacteriolytic enzyme with a molecular weight of about 22 kDa), protease, polysaccharide, and ballast components. The method of production of the bacteriolytic complex includes cultivation of the strain-producer on a nutrient medium containing glucose, peptone, yeast extract or yeast autolysate, phosphate salts of sodium and potassium, magnesium sulfate, potassium chloride, iron sulfate, and water.Type: GrantFiled: November 28, 2001Date of Patent: December 19, 2006Assignee: Institut Biokhimii I Fisiologii Mikroorganismov IM. G.K.Skrjabina Rossiiskoi Akademii Nauk (IBFM RAN)Inventors: Igor Stepanovich Kulaev, Olga Andreevna Stepnaja, Irina Matveevna Zfasman, Taisija Sergeevna Tchermenskaja, Larisa Aleksandrovna Ledova, Ljudmila Grigorevna Zubrizkaja, Vassily Konstantinovich Akimenko
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Patent number: 7067124Abstract: There is provided methods, kits, combinations, and compositions comprising a Aspergillus oryzae protease enzyme, a Bacillus subtilis protease enzyme, and a Aspergillus niger lipase enzyme for treating a digestive disorder in a subject in need thereof. The methods, kits, combinations, and compositions may also be used along with an agent (or combination of agents) for raising the gastric pH, a digestive enzyme useful in enhancing digestive activity, a dietary supplement, or a pharmaceutical agent.Type: GrantFiled: March 28, 2003Date of Patent: June 27, 2006Assignee: National Enzyme CompanyInventors: John G. Davidson, Rohit Medhekar, Jeremy Moore, Ken Paydon, Steve Marr
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Patent number: 7056499Abstract: The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: GrantFiled: February 8, 2002Date of Patent: June 6, 2006Assignee: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Patent number: 7005128Abstract: The use is provided of a composition as a feed additive which comprises one or more endoglucanases, and 0–20% by weight, based upon the content of cellulase proteins in the composition, of a cellobiohydrolase. The endoglycanases may be one or more of EGI, EGII, EGIII and any functionally active derivative of any thereof. Such endoglucanases may be obtained from a genetically modified strain of the fungus Trichoderma. Also provided is an enzyme-based feed additive which comprises EGI and/or EGII which lack the cellulose binding domain, and 0–20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. A further enzyme-based feed additive is provided which comprises a cereal-based carrier, one or more endoglucanases, and 0–20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. Such enzyme-based feed additives can be incorporated into a cereal-based feed which includes one or more of barley, wheat, triticale, rye and maize.Type: GrantFiled: March 4, 2003Date of Patent: February 28, 2006Assignees: Genencor International, Inc., Finnfeeds International, Ltd.Inventors: Michael R. Bedford, Andrew J. Morgan, Timothy Fowler, Kathleen A. Clarkson, Michael Ward, Katherine D. Collier, Edmund A Larenas
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Patent number: 6953571Abstract: A cosmetic-pharmaceutical composition for topical use against human alopecia containing a pool of enzymes of the specific hydroxisteroido-dehydrogenase group in the presence of nicotinamido-adenine-dinucleotide coenzyme and a vasodilator, the whole being complexed with phospholipids in solution.Type: GrantFiled: February 27, 2004Date of Patent: October 11, 2005Assignee: Farmaka s.r.l.Inventor: Ugo Raffaello Citernesi
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Patent number: 6913744Abstract: A method of treating prostate cancer in a living mammal includes local administration of a composition that includes a therapeutically effective concentration of collagenase. In one embodiment, a method of treating prostate cancer in a living mammal includes local administration of a composition that includes a therapeutically effective concentration of collagenase and at least one of a glycosidase, a protease, a nuclease, a lipase, an esterase, a plasminogen activator, a streptokinase, and combinations thereof. Preferably a glycosidase, such as, for example, hyaluronidase, is administered. Compositions used in methods for treating prostate cancer can also include or be administered with calcium ions, a nonionic surfactant, such as, for example, Triton® X-100, and an antibiotic, such as, for example, gentamicin. Another method of treating prostate cancer in a living mammal includes activating PSA in vivo by, for example, locally administering calcium ions.Type: GrantFiled: January 22, 2002Date of Patent: July 5, 2005Assignee: Immunolytics Inc.Inventor: Muharrem Gokcen
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Patent number: 6908628Abstract: Wide spectrum disinfecting and antiseptic composition for use in the fields of human medicine, veterinary science and industry, characterized because it includes: Hydrogen peroxide, lactic acid and halogen salts (Br, I) and/or salts of heavy metals (for example, silver halides) with surfactant agents, either cationic, like chlorhexidine and/or quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, chlorides of ammonium or compounds of ammonium propylamide or anionic, like lauryl sulphate, dodecyl sulphate or alkyl succinic salts, with suitable excipients, some of which may be ethyl or isopropyl alcohol, chlorhexidine, non-chlorinated quaternary ammonium salts, like didecyl-methyl-polyoxy-ethyl-ammonium propionate, combined or not with iodine, and/or its salts, together with excipients, some of which may be ethyl or isopropyl alcohol.Type: GrantFiled: June 10, 2002Date of Patent: June 21, 2005Assignee: OFTRAI, S.L.Inventor: Rafael Herruzo Cabrera
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Patent number: 6884415Abstract: The antioxidation food product of the present invention is produced by fermenting a food product containing bacteria having catalase activity, such as Lactobacillus plantarum, in the presence of a manganese-containing natural material. The antioxidation food product has antioxidation activity in viva, including the digestive tract, by simultaneously expressing a superoxide dismutase-like activity and a catalase activity, and is effective for preventing disease caused by active oxygen.Type: GrantFiled: December 21, 2001Date of Patent: April 26, 2005Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masamichi Toba, Shigeto Uchiyama, Reiko Ohta, Seiichi Shimizu, Shuichi Sakamoto
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Patent number: 6858215Abstract: Novel compositions and methods for treatment of hyperkeratotic mammalian tissue are disclosed employing proteolytic enzymes originally developed for the hydrolysis of food-related proteins and currently commonly used as food grade meat tenderizers and flavor enhancers. The compositions containing these proteinases soften, thin and exfoliate hyperkeratotic formations on the skin, including calluses, corns, dry, scaling/flaking skin and keratoses without harming surrounding tissue by selective lysing of hyperkeratotic tissue. Such enzymes accomplish this by lysing only the 10-end peptide bonds of keratin protein, the dominant protein component of hyperkeratotic skin.Type: GrantFiled: June 14, 2002Date of Patent: February 22, 2005Inventor: Carol J. Buck
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Publication number: 20040258736Abstract: A method of stimulating or enhancing an ornithine-urea cycle in ruminant gut tissues, which entails either feeding to a ruminant an effective amount of a ruminant feed or feed supplement containing an effective amount of a compound which stimulates activity of one or more enzymes required in the ornithine-urea cycle.Type: ApplicationFiled: June 4, 2004Publication date: December 23, 2004Inventor: Brian James Bequette
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Publication number: 20040258621Abstract: A method of pharmaceutically managing snoring and impaired breathing is provided. This invention relates to treating snoring, sleep apnea, and other forms of sleep-disordered breathing in those with or without symptoms of or the diagnosis of gastro-intestinal reflux disease (GERD). It comprises administration of a therapeutically effective dose of Prevacid (Lansoprazole) or any other medication that can be used to treat symptoms of hyper-acidity or gastrointestinal reflux disease (GERD). The therapeutic medication may be used alone or in combination with other pharmacologic agents or mechanical modalities including but not limited to decongestants, antihistamines or mechanical nasal toilet. It also is of benefit in improving breathing disorders that are present while awake.Type: ApplicationFiled: October 16, 2003Publication date: December 23, 2004Inventor: Warren Stern
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Patent number: 6830917Abstract: The present invention is directed to methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease in a single affinity chromatography step and uses of the purified SGT.Type: GrantFiled: December 10, 2001Date of Patent: December 14, 2004Assignee: Baxter Healthcare S.A.Inventors: Artur Mitterer, Christa Tauer, Manfred Reiter, Wolfgang Mundt
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Publication number: 20040241154Abstract: The invention is based on the finding that the secretin receptor is expressed in tissues present in the distal lung of humans. In patient with asthma, levels of the receptor are elevated compared to normal tissue. Treatment of tissue by secretin stimulates the movement of negative ions in the tissue. Addition of secretin to human bronchial tissue in vitro stimulates bronchorelaxation. The invention provides methods of treatment of asthma in a patient by administering to said patient an effective amount of an agent which triggers anion efflux and bronchorelaxation in respiratory tissue via the activation of a secretin receptor.Type: ApplicationFiled: June 30, 2004Publication date: December 2, 2004Inventors: Richard Jon Davis, Kenneth Clark
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Patent number: 6818233Abstract: The invention provides a dietary supplement comprising at least one flavonoid source and an enzyme, that is effective for inhibiting in vivo platelet activity and LDL cholesterol oxidation in a mammal at a dosage of about 30 mg/Kg or less. The supplement may contain flavonoid sources found in grape seed extracts, grape skin extracts, bilberry extracts, ginkgo biloba extracts or the flavonoid quercetin. The supplement may also contain fungal proteases, acid stable proteases and bromelain. The invention further provides a method for using the dietary supplement and an article of manufacture containing the supplement.Type: GrantFiled: November 20, 1998Date of Patent: November 16, 2004Assignee: Melaleuca, Inc.Inventor: Lynn Perkes
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Patent number: 6814964Abstract: A supramolecule has a first supramolecular component including a first effector molecule covalently joined to a first nucleic acid, and a second supramolecular component including a second effector molecule covalently joined to a second nucleic acid, wherein the second nucleic acid has a region of at least partial complementarity to the first nucleic acid, wherein the first nucleic acid is in a base pairing relationship with the second nucleic acid and the first or second effector molecules are proteins, polypeptides, lipids or sugars. The supramolecule may further have a third supramolecule component which includes a third effector molecule covalently joined to a third nucleic acid, wherein the third nucleic acid has a region of at least partial complementary to the first nucleic acid or the second nucleic acid and wherein the third nucleic acid is in a base pairing relationship with the second nucleic acid or the first nucleic acid.Type: GrantFiled: March 25, 2002Date of Patent: November 9, 2004Assignees: Nagaoka & Co. Ltd., Burnstein Technologies, Inc.Inventors: Jorma Virtanen, Sinikka Virtanen
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Publication number: 20040213773Abstract: A composition and a method for treatment of urinary tract dysfunction and, particularly, non-bacterial cystitis and, even more particularly, non-bacterial chronic interstitial cystitis. The composition primarily relies upon the use of a bioflavonoid and, particularly, that bioflavonoid known as quercetin. The quercetin is mixed with a proteolytic digestive enzyme protease, such as bromelin and papain, as the primary active ingredients. However, the composition may optionally and beneficially include other cystitis affecting agents, such as cranberry, as well as some other active and non-active ingredients.Type: ApplicationFiled: April 22, 2003Publication date: October 28, 2004Inventor: Floyd A. Katske
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Publication number: 20040197321Abstract: Method of preventing or reducing diarrhea and correcting fat malabsorption (steatorrhea) and loss of body mass in HIV-positive patients being treated with High Activity Antiretroviral drugs (HAART) containing protease inhibitors, nucleoside reverse transcriptase inhibitors or non-nucleoside reverse transcriptase inhibitors and by co-administering with the HAART a buffered pancrelipase composition. The method includes the steps of: administering to the HIV-positive patient a High Activity Antiretroviral drug containing a protease inhibitor, a nucleoside reverse transcriptase inhibitor or a non-nucleoside reverse transcriptase inhibitor; and co-administering with the HAART drug a gastric acid-resistant polymer-coated and buffered pancrelipase enzyme composition containing pancreatic proteases, lipases, co-lipases, nucleases, amylases and other bio-active substances produced by the pancreatic gland.Type: ApplicationFiled: April 8, 2004Publication date: October 7, 2004Inventors: Tibor Sipos, Simantini Das, Terese Marie Wignot
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Publication number: 20040191237Abstract: There is provided methods, kits, combinations, and compositions comprising a Aspergillus oryzae protease enzyme, a Bacillus subtilis protease enzyme, and a Aspergillus niger lipase enzyme for treating a digestive disorder in a subject in need thereof. The methods, kits, combinations, and compositions may also be used along with an agent (or combination of agents) for raising the gastric pH, a digestive enzyme useful in enhancing digestive activity, a dietary supplement, or a pharmaceutical agent.Type: ApplicationFiled: March 28, 2003Publication date: September 30, 2004Inventors: John G. Davidson, Rohit Medhekar, Jeremy Moore, Ken Paydon, Steve Marr
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Publication number: 20040191238Abstract: The invention is based on the finding that the secretin receptor is expressed in tissues present in the distal lung of humans. In patient with CF, levels of the receptor are elevated compared to normal tissue. Treatment of tissue by secretin stimulates the movement of negative ions in the tissue. The invention provides methods of treatment of cystic fibrosis or COPD in a patient by administering to said patient an effective amount of an agent which triggers anion efflux in respiratory tissue via the activation of a secretin receptor.Type: ApplicationFiled: April 13, 2004Publication date: September 30, 2004Applicant: Pharmagene Laboratories Ltd.Inventors: Richard J. Davis, Keith J. Page
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Publication number: 20040161483Abstract: The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: ApplicationFiled: February 13, 2004Publication date: August 19, 2004Applicant: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Patent number: 6777223Abstract: The present invention relates to methods for preventing or removing biofilm on a surface, comprising contacting the surface with an effective amount of a composition comprising one or more acylases and a carrier to degrade a lactone produced by one or more microorganisms, wherein the degradation of the lactone prevents or removes the biofilm.Type: GrantFiled: June 19, 2001Date of Patent: August 17, 2004Assignee: Novozymes Biotech, Inc.Inventor: Feng Xu
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Publication number: 20040146494Abstract: The present invention refers to a pharmaceutical composition applied to treat the Peyronie disease and the collage-nous and fibrotic pathologies and its corresponding obtainment process. The composition comprises in its formulation papaine and eventually vitamin-E and/or hyaluronidase.Type: ApplicationFiled: March 3, 2004Publication date: July 29, 2004Inventor: Cristiano Alberto Ribeiro Santana
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Patent number: RE39238Abstract: Transgenic pathogen-resistant organism whose genome contains at least two different genes under the control of active promoters with pathogen-inhibiting action. This organism is distinguished by a synergistic pathogen-inhibiting action. This action is evident particularly when the genes code for the gene products chitinase (ChiS, ChiG), glucanase (GluG), protein synthesis inhibitor (PSI) and antifungal protein (AFP).Type: GrantFiled: December 1, 2000Date of Patent: August 15, 2006Assignee: Max-Planck-Gesellschaft zür Forderung der Wissenschaften e.V.Inventors: Jürgen Logemann, Guido Jach, Birgit Görnhardt, John Mundy, Jeff Schell, Peter Eckes, Ilan Chet