Acting On Glycosyl Compound (3.2) (e.g., Glycosidases Lysozyme, Nucleosidases, Cellulase, Etc.) Patents (Class 424/94.61)
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Publication number: 20140161788Abstract: The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.Type: ApplicationFiled: November 27, 2013Publication date: June 12, 2014Applicant: BioMarin Pharmaceutical Inc.Inventors: Mika Aoyagi-Scharber, Teresa Margaret Christianson, Melita Dvorak-Ewell, Daniel J. Wendt, Shinong Long, Jonathan LeBowitz, Daniel Solomon Gold
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Publication number: 20140161787Abstract: A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic agent may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic agent may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using of a biomarker, the presence of chymotrypsin in the gastrointestinal tract to determine the presence of symptoms of addiction, and the likelihood of relapsing into addiction is disclosed.Type: ApplicationFiled: June 25, 2013Publication date: June 12, 2014Applicant: CUREMARK LLCInventor: Joan M. Fallon
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Patent number: 8748150Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.Type: GrantFiled: May 21, 2012Date of Patent: June 10, 2014Assignee: GangaGen, Inc.Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
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Publication number: 20140147500Abstract: Pharmaceutical compositions comprising one or more digestive enzymes and one or more gastrointestinal modulators of acid are provided. The one or more digestive enzymes may be coated, e.g., with a lipid. Also disclosed are methods for their use and controlled delivery in treating individuals with neurological, behavioral, infectious, or genetic diseases or conditions susceptible to treatment with digestive enzymes.Type: ApplicationFiled: November 19, 2010Publication date: May 29, 2014Inventors: Joan M. Fallon, Matthew Heil, James F. Szigethy, James Fallon
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Publication number: 20140134146Abstract: The present application discloses a fouling release cured paint coat comprising a polysiloxane-based binder matrix constituting at least 40% by dry weight of the coat, and one or more enzymes. The application further discloses a kit for preparing a fouling release coat, a coating composition comprising a polysiloxane-based binder system comprising one or more polysiloxane components modified with hydrophilic oligomer/polymer moieties, and one or more enzymes, and a coating composition comprising a polysiloxane-based binder system, 0.01-20% by dry weight of one or more hydrophilic-modified polysiloxane oils, and one or more enzymes.Type: ApplicationFiled: June 29, 2012Publication date: May 15, 2014Applicant: HEMPEL A/SInventors: Stefan Møller Olsen, Diego Meseguer Yebra
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Publication number: 20140134149Abstract: Enzymes for inhibiting growth of biofilms and degrading biofilms. The enzymes comprise glycosyl hydrolases capable of degrading biofilms. The enzymes are formulated in compositions with and without antimicrobial agents. The enzymes with and without the antimicrobial agents are delivered to biofilms to degrade the biofilms and treat infections of microorganisms associated with the biofilms, delivered to surfaces to inhibit growth of biofilms thereon, and administered to animals to inhibit growth of biofilms therein.Type: ApplicationFiled: November 11, 2013Publication date: May 15, 2014Applicant: C5-6 Technologies, Inc.Inventor: Phillip J. Brumm
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Publication number: 20140134150Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.Type: ApplicationFiled: January 6, 2014Publication date: May 15, 2014Applicant: Ansun Biopharma, Inc.Inventors: Michael P. Malakhov, Fang Fang
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Publication number: 20140127307Abstract: The present invention relates to a small particle size composition comprising pancreatin containing digestive enzymes for use in patients in need, including pediatric, geriatric, and adult patients, particularly those patients with dysphagia or wherein enteral administration using such composition would be suitable. In addition, the invention is directed to the composition as particles, such as micropellets or microgranules having a high potency, high useable yield and at least 10%-90% of 400-800 ?m. Furthermore, the composition optionally has an improved enteric coating and concomitant improved stability and enzyme activity compared to conventional prepared enterically coated pancreatic enzyme particles.Type: ApplicationFiled: November 2, 2012Publication date: May 8, 2014Applicant: APTALIS PHARMA LIMITEDInventors: Gopi M. VENKATESH, Craig Kramer, Flavio Fabiani, Luigi Mapelli, Giovanni Ortenzi, Massimo Latino
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Publication number: 20140127227Abstract: Provided are stable protein formulations that contain at least one amino acid. In certain embodiments, amino acid combinations either at least two, or three, or four, or more amino acids are included. By virtue of inclusion of the amino acids, the formulation has low viscosity and a protein in the formulations is physically, chemically, and biological stable even at high concentrations. In further embodiments, by virtue of inclusion of the amino acids, a protein in the formulations is physically, chemically, and biological stable even at high concentrations.Type: ApplicationFiled: October 26, 2012Publication date: May 8, 2014Inventor: Byeong Seon Chang
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Patent number: 8715647Abstract: The use is provided composition as a feed additive which comprises one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the composition, of a cellobiohydrolase. The endoglycanases may be one or more of EGI, EGII, EGIII and any functionally active derivative of any thereof. Such endoglucanases may be obtained from a genetically modified strain of the fungus Trichoderma. Also provided is an enzyme-based feed additive which comprises EGI and/or EGII which lack the cellulose binding domain, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase. A further enzyme-based feed additive is provided which comprises a cereal-based carrier, one or more endoglucanases, and 0-20% by weight, based upon the content of cellulase proteins in the additive, of a cellobiohydrolase.Type: GrantFiled: August 5, 2005Date of Patent: May 6, 2014Assignee: Danisco US Inc.Inventors: Michael R. Bedford, Andrew J. Morgan, Timothy Fowler, Kathleen A. Clarkson, Michael Ward, Katherine D. Collier, Edmund A. Larenas
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Patent number: 8715995Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: November 16, 2012Date of Patent: May 6, 2014Assignees: Novozymes A/S, Novozymes Inc.Inventor: Marc Dominique Morant
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Patent number: 8709408Abstract: The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B.Type: GrantFiled: November 16, 2012Date of Patent: April 29, 2014Assignees: Icahn School of Medicine at Mount Sinai, Genzyme CorporationInventors: Edward H. Schuchman, Robert J. Desnick, Gerald F. Cox, Laura P. Andrews, James M. Murray
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Patent number: 8709386Abstract: Isolated ?-glucanases from Hypocrea tawa, Trichoderma reesei, and Trichoderma konilangbra are described, as well as oral care compositions containing the same. The oral care composition may be employed to prevent or reduce dental plaque.Type: GrantFiled: April 9, 2009Date of Patent: April 29, 2014Assignee: Danisco US Inc.Inventors: Steven Kim, Suzanne Lantz, Michael Pepsin
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Publication number: 20140112907Abstract: A method for the augmentation of immune function is described. The invention comprises a combination of ?-1,3(4)-endoglucanohydrolase, ?-1,3(4)-glucan, diatomaceous earth, mineral clay and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to augment immune function. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species.Type: ApplicationFiled: December 20, 2013Publication date: April 24, 2014Applicant: OmniGen Research, L.L.C.Inventors: Neil E. Forsberg, Steven B. Puntenney
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Patent number: 8697065Abstract: The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target cell-specific delivery vector, such as an antibody, for delivery to pathogenic cells.Type: GrantFiled: June 20, 2013Date of Patent: April 15, 2014Assignee: Quintessence Biosciences, Inc.Inventors: Laura E. Strong, Peter A. Leland, Thomas Burke
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Patent number: 8697359Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system.Type: GrantFiled: October 15, 2013Date of Patent: April 15, 2014Assignees: The Broad Institute, Inc., Massachusetts Institute of TechnologyInventor: Feng Zhang
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Publication number: 20140099380Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.Type: ApplicationFiled: June 28, 2013Publication date: April 10, 2014Inventors: Michael P. Malakhov, Tiejun Li
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Publication number: 20140099296Abstract: A skin and/or oral treatment mixture for treating tattooed or pierced skin such as that resulting from a body piercing, oral piercing, or tattoo procedure includes non-iodized sodium chloride, distilled water, aloe, and lysozyme. The distilled water is preferably a product of vapor or steam distillation. The Aloe is preferably pure aloe barbadensis leaf extract. A method of producing a skin and/or oral treatment mixture includes the steps of providing a quantity of distilled water; adding a quantity of non-iodized sodium chloride; Heating the quantities of vapor distilled water and non-iodized sodium chloride to 70 degrees Celsius; Cooling the water/sodium mixture to 40 degrees celcius; adding a quantity of aloe barbadensis and a quantity of lysozyme; stirring the mixture. A method for treating the tattooed or pierced area of a persons skin includes applying to the pierced or tattooed area a distilled water, sodium chloride, aloe and lysozyme.Type: ApplicationFiled: October 4, 2012Publication date: April 10, 2014Inventor: Jeffrey Allen Covell
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Patent number: 8691218Abstract: The present invention provides a mimetic egg comprising lysozyme, a salt or biological fragment thereof or a lysozyme-related peptide and an active ingredient in its base material mimicking an egg of a vermin; and a vermin exterminating method using the mimetic egg.Type: GrantFiled: February 15, 2008Date of Patent: April 8, 2014Assignee: National University Corporation Okayama UniversityInventors: Kenji Matsuura, Takashi Tamura, Norimasa Kobayashi
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Patent number: 8691213Abstract: The invention relates to the use of composition comprising free amino acids as a sole source of protein, a fatty acid source comprising long chain polyunsaturated fatty acids, a carbohydrate source comprising digestible and indigestible carbohydrates, and milk protein free Bifidobacteria for treating a person suffering from (a) colic, congestion, runny nose, wheezing, vomiting, diarrhea, bloody stools, mucus in stools, rash, eczema, gastroesophageal reflux, eosinophilic esophagitis or asthma; (b) cow's milk allergy and/or food protein intolerance; and/or (c) infections, wherein the indigestible carbohydrate is selected from a milk protein free source and the total composition is essentially free of intact proteins.Type: GrantFiled: July 5, 2007Date of Patent: April 8, 2014Assignee: SHS InternationalInventors: Jane Elizabeth Langford, Ian Sullivan, Catherine Teresa Deering, Sandra Helen Giffen
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Publication number: 20140086896Abstract: The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.Type: ApplicationFiled: November 19, 2013Publication date: March 27, 2014Applicant: AMICUS THERAPEUTICS, INC.Inventors: Robert Boyd, Gary Lee, Philip Rybczynski
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Patent number: 8679481Abstract: A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.Type: GrantFiled: May 9, 2011Date of Patent: March 25, 2014Assignee: Acorda Therapeutics, Inc.Inventors: Elliott A. Gruskin, Jack L. Tseng, Anthony O. Caggiano
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Publication number: 20140079671Abstract: The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophage F387/08, F391/08, F394/08, F488/08, F510/08, F44/10, and F125/10, isolated polypeptides thereof, compositions comprising one or more of the novel bacteriophage and/or isolated polypeptides, as well as to methods for the treatment and prevention of bacterial infections using same, either alone or in combination with other antibacterial therapies, e.g., antibiotics and/or other phage therapies.Type: ApplicationFiled: September 19, 2011Publication date: March 20, 2014Applicants: TECHNOPHAGE, INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SA, TECNIFAR-INDÚSTRIA TÉCNICA FARMACÊUTICA, S.A.Inventors: Miguel Ângelo Da Costa Garcia, Carlos Jorge Sousa De São José, Clara Isabel Rodrigues Leandro, Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva, Ana Raquel Martins Barbosa
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Publication number: 20140079683Abstract: A multifunctional polypeptide capable of hydrolyzing cellulosic materials, xylan, and mannan is disclosed. The polypeptide includes the catalytic core (cc) of Clostridium thermocellum Cthe_0797 (CelE), the cellulose-specific carbohydrate-binding module CBM3 of the cellulosome anchoring protein cohesion region (CipA) of Clostridium thermocellum (CBM3a), and a linker region interposed between the catalytic core and the cellulose-specific carbohydrate binding module. Methods of using the multifunctional polypeptide are also disclosed.Type: ApplicationFiled: September 18, 2013Publication date: March 20, 2014Applicant: Wisconsin Alumni Research FoundationInventors: Brian G. Fox, Taichi Takasuka, Christopher M. Bianchetti
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Publication number: 20140079727Abstract: The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO:1. The present invention further relates to the nucleic acid molecules comprising a nucleotide sequence coding for the polypeptide, vectors comprising the nucleic acid molecules, and host cells for the expression of the polypeptides. In addition, the present invention relates to the use of the polypeptide as a human medical, veterinary medical or diagnostic substance, as an antimicrobial substance in food, in cosmetics, as disinfecting agent or in the environmental field.Type: ApplicationFiled: July 24, 2009Publication date: March 20, 2014Inventors: Martin Loessner, Mathias Schmelcher
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Publication number: 20140072549Abstract: The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.Type: ApplicationFiled: April 20, 2012Publication date: March 13, 2014Inventors: Vincent A. Fischetti, Jonathan Schmitz, Daniel Gilmer, Chad Euler
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Patent number: 8668907Abstract: The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having ?-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired ?-galactosidase activity by changing the structure of the active site of wild-type human ?-N-acetylgalactosaminidase.Type: GrantFiled: November 2, 2012Date of Patent: March 11, 2014Assignees: Tokyo Metropolitan Institute of Medical Science, Altif LaboratoriesInventors: Hitoshi Sakuraba, Youichi Tajima, Mai Ito, Seiichi Aikawa, Fumiko Aikawa
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Publication number: 20140065128Abstract: The invention provides an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, for use in a method for treating or preventing a disease or condition mediated by IgE antibodies.Type: ApplicationFiled: March 5, 2012Publication date: March 6, 2014Applicant: HANSA MEDICAL ABInventors: Mattias Collin, Rolf Lood, Karl Carlstrom, Maria Allhorn, Jonathan Sjogren, Falk Nimmerjahn
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Publication number: 20140065127Abstract: Methicillin-resistant (MRSA) and multi-drug resistant strains of Staphylococcus aureus are becoming increasingly prevalent in both human and veterinary clinics. S. aureus-causing bovine mastitis yields high annual losses to the dairy industry. Treatment of mastitis by broad range antibiotics is often not successful and may contribute to development of antibiotic resistance. Bacteriophage endolysins are a promising new source of antimicrobials. The endolysin of prophage ?SH2 of Staphylococcus haemolyticus strain JCSC1435 (?SH2 lysin) shows lytic activity against live staphylococcal cells. Deletion constructs were tested in zymograms and turbidity reduction assays to evaluate the contribution of each functional module to lysis. The CHAP domain exhibited three-fold higher activity than the full length protein. Activity was further enhanced in the presence of bivalent calcium ions.Type: ApplicationFiled: September 6, 2012Publication date: March 6, 2014Inventors: David M. Donovan, Igor V. Abaev, Mathias Schmelcher
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Publication number: 20140065161Abstract: A treatment composition for treating or preventing bovine mastitis, the treatment composition characterised in that it includes at least two components which have an isoelectric point of or above substantially 6.8 and is extracted from milk, or a milk derived substance.Type: ApplicationFiled: September 4, 2013Publication date: March 6, 2014Applicant: DEC International NZ LimitedInventor: Judith Mary Bragger
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Publication number: 20140065104Abstract: The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.Type: ApplicationFiled: September 9, 2013Publication date: March 6, 2014Applicant: Hyglos Invest GmbHInventors: Michael FORCHHEIM, Holger GRALLERT, Anja PHILIPP, Manfred BIEBL
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Patent number: 8658162Abstract: The invention relates to dose escalation enzyme replacement therapy using acid sphingomyelinase (ASM) for the treatment of human subjects having acid sphingomyelinase deficiency (ASMD), and, in particular, patients with non-neurological manifestations of Niemann-Pick Disease (NPD), and in certain embodiments, NPD type B.Type: GrantFiled: November 16, 2012Date of Patent: February 25, 2014Assignees: Icahn School of Medicine at Mount Sinai, Genzyme CorporationInventors: Edward H. Schuchman, Robert J. Desnick, Gerald F. Cox, Laura P. Andrews, James M. Murray
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Publication number: 20140050715Abstract: This invention is directed to the use of a protein hydrolysate, and in particular an egg lysozyme hydrolysate to assist an animal, including a human in overcoming an addition, or by breaking an unwanted habit.Type: ApplicationFiled: April 26, 2012Publication date: February 20, 2014Applicant: DSM IP Assets B.V.Inventors: Guillen Santiago Eusebio Fernandez-Ruemann, Regina Goralczyk, Joris Kloek, Marijn Christoffrel Waander Kroes, Hasan Mohajeri, Guido Alexander Van Wingen, Jonas Wittwer
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Publication number: 20140050714Abstract: The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.Type: ApplicationFiled: August 19, 2013Publication date: February 20, 2014Applicant: ORPHAZYME APSInventors: Thomas Kirkegaard Jensen, Marja H. Jaattela
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Patent number: 8652464Abstract: The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.Type: GrantFiled: December 4, 2012Date of Patent: February 18, 2014Assignee: Alkermes Pharma Ireland LimitedInventors: Christian F. Wertz, Niels P. Ryde
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Publication number: 20140044699Abstract: The present invention provides a pharmaceutical composition comprising a protein having ?-galactosidase activity for treating Fabry disease, which causes no allergic side effect, which is highly stable in blood (plasma) and which can readily be taken up by a cell of an affected organ. The pharmaceutical composition for treating Fabry disease of the invention comprises, for example, a protein which acquires an ?-galactosidase activity through alteration of the structure of the active site of wild-type human ?-N-acetylgalactosaminidase.Type: ApplicationFiled: September 13, 2013Publication date: February 13, 2014Applicants: ALTIF LABORATORIES INC., TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCEInventors: Hitoshi SAKURABA, Youichi TAJIMA, Ikuo KAWASHIMA, Seiichi AIKAWA, Fumiko AIKAWA
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Publication number: 20140037609Abstract: The invention relates to an insecticidal protein, its gene encoding and the uses thereof. The protein comprises: (a) a protein consisting of an amino acid sequence shown by SEQ ID NO:2 or a sequence of amino acid residuses at positions 1 to 640 thereof; or (b) a protein derived from (a) by substitution, deletion, or addition of one or more amino acid residuses of the amino acid sequences in (a), and having insecticidal activity; or (c) a protein generated by the expression of nucleic acid molecules containing a sequence of amino acid residuses at the positions 1 to 1920 of SEQ ID NO:1; or (d) a protein generated by the expression of nucleic acid molecules containing a complementary sequence that hybridized with the sequence of nucleotides at the positions 1 to 1920 of SEQ ID NO:1 under stringent conditions. The protein has high expression level and strong toxicity against pests.Type: ApplicationFiled: March 18, 2013Publication date: February 6, 2014Inventors: AIHONG ZHANG, Jie Pang, Ruiqi Niu, Lihong Niu, Chao Gao, Mengmeng Miao, Donghai Yang
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Publication number: 20140037612Abstract: The invention relates, in part, to improved methods of administering ?-galactosidase A for the treatment of ?-galactosidase A deficiencies including Fabry disease.Type: ApplicationFiled: May 24, 2013Publication date: February 6, 2014Applicant: Shire Human Genetic Therapies Inc.Inventors: Lisa Marie Sturk, Justin C. Lamsa, Michael W. Heartlein, Vinh Nguyen, Katherine D. Taylor, Zahra Shahrokh
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Publication number: 20140037611Abstract: The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a patient.Type: ApplicationFiled: May 3, 2013Publication date: February 6, 2014Applicant: Genzyme Therapeutic Products Limited PartnershipInventors: Johannes B.M.M. van Bree, Edna H.G. Venneker, David P. Meeker
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Publication number: 20140037608Abstract: The invention relates to an insecticidal protein, its gene encoding and the uses thereof. The protein comprises: (a) a protein consisting of an amino acid sequence shown by SEQ ID NO:2; or (b) a protein derived from (a) consisting of an amino acid sequence by substitution, deletion, or addition of one or more amino acid residues of the amino acid sequences in (a), and having insecticidal activity; or (c) a protein generated by the expression of nucleic acid molecules containing a nucleotide sequence of SEQ ID NO:1; or (d) a protein generated by the expression of nucleic acid molecules containing a complementary sequence that hybridized with SEQ ID NO:1 under stringent conditions; or (e) a protein generated by the expression of nucleic acid molecules that contain nucleotide sequences isocoding with the nucleotide sequences in (d). The insecticidal protein of the invention has high expression level and strong toxicity against pests.Type: ApplicationFiled: March 18, 2013Publication date: February 6, 2014Inventors: AIHONG ZHANG, Jie Pang, Ruiqi Niu, Lihong Niu, Na Wang, Jincun Huang, Yujie Qi
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Publication number: 20140030333Abstract: A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and the method for preparing the therapeutic agents is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic agent may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic agent may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using of a biomarker, the presence of chymotrypsin in the maternal GI tract to determine the likelihood of developing preeclampsia, pregnancy induced hypertension, and eclampsia/toxemia is disclosed.Type: ApplicationFiled: September 26, 2013Publication date: January 30, 2014Applicant: CUREMARK, LLCInventor: Joan M. Fallon
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Publication number: 20140023633Abstract: A method for the augmentation of immune function is described. The invention comprises a combination of ?-1,3 (4)-endoglucanohydrolase, ?-1,3 (4)-glucan, diatomaceous earth, mineral clay and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to augment immune function. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species.Type: ApplicationFiled: September 24, 2013Publication date: January 23, 2014Applicant: OmniGen Research, L.L.C.Inventors: Neil E. Forsberg, Steven B. Puntenney
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Publication number: 20140017212Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease.Type: ApplicationFiled: March 15, 2013Publication date: January 16, 2014Inventor: Edward J. Rebar
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Publication number: 20140017224Abstract: The present invention relates to a polypeptide with endolysin activity comprising an amino acid sequence according to SEQ ID No. 1 and fragments or derivatives thereof, or fusion proteins derived thereof. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide or fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said polypeptide, fragment, derivative or fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, as cosmetic substance or as sanitizing agent.Type: ApplicationFiled: November 3, 2011Publication date: January 16, 2014Applicants: UNIVERSITY OF MINHO, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&DInventors: Joana Cecilia Valente Rodrigues Azeredo, Silvio Roberto Branco Dos Santos, Leonardus Dorothea Kluskens, Rob Lavigne, Maarten Walmagh
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Publication number: 20140010801Abstract: This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or improves health of the mammal. In addition, the invention also relates to compositions containing one or more regulatory factors secreted or released from isolated mammalian stem/progenitor cells and use of such compositions to extend lifespan and/or improve health of a mammal. Also provided are methods of treating, delaying, preventing or reversing progeria or related syndromes in a mammal using isolated autologous or allogeneic stem/progenitor cells and/or regulatory factors secreted or released therefrom.Type: ApplicationFiled: June 7, 2013Publication date: January 9, 2014Inventors: Laura J. Niedernhofer, Mitra Lavasani, Paul D. Robbins, Johnny Huard
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Publication number: 20140007292Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: March 11, 2013Publication date: January 2, 2014Applicant: Pioneer Hi Bred International IncInventors: David C. Cerf, James J. English, Carol A. Hendrick, Lu Liu, Jarred K. Oral, Phillip A. Patten, Barbara A. Rosen, Ute Schellenberger, Ingrid A. Udranszky, Jun-Zhi Wei, Genhai Zhu
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Publication number: 20130344054Abstract: Described herein are variant, recombinant ?-glucocerebrosidase proteins characterized as having increased stability relative to recombinant wild-type ?-glucocerebrosidase. Also provided herein are variant, recombinant ?-glucocerebrosidase proteins characterized as retaining more catalytic activity relative to recombinant wild-type ?-glucocerebrosidase. Further described herein are variant, recombinant ?-glucocerebrosidase proteins that can have amino acid variations at one or more of the following positions: 316, 317, 321 and 145. Methods of making the variant, recombinant ?-glucocerebrosidase proteins are also described as well as methods of treating patients having lysosomal storage diseases.Type: ApplicationFiled: November 8, 2011Publication date: December 26, 2013Applicant: Callidus Biopharama, Inc.Inventor: Hung Do
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Publication number: 20130344145Abstract: A pharmaceutical composition or formulation adapted for oral administration in tablet, coated tablet, capsule or reconstitutable powder form for the prevention or treatment of intestinal disorders such irritable bowel syndrome, also known as irritable colon syndrome, based on an intestinal motility modifier, an agent that prevents gas retention, of digestive enzymes, a binding agent, a diluting agent, an absorbent agent, a lubricant, aglidant, and an disintegrating agent or suspending agent, effective in the normalization of intestinal disorders, to achieve an analgesic activity, to achieve an anti-spasmic activity and to reduce the symptoms associated with intestinal gas such as distention, abdominal pain and flatulence.Type: ApplicationFiled: November 15, 2011Publication date: December 26, 2013Applicant: Posi Visionary Solutions LLPInventor: Alana Noelle Denise Savoir Garcia
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Publication number: 20130336955Abstract: A fusion protein comprising at least one Type 1 Ribosome Inactivating Protein, polypeptide B; and at least one polypeptide A capable of viral entry inhibition; and/or at least one Cationic AntiMicrobial Peptide, polypeptide C.Type: ApplicationFiled: January 9, 2012Publication date: December 19, 2013Applicant: VALIANT BIOPHARMA SDN BHDInventors: Muhammad Sagaf Abu Bakar, Ag., Eng Huan Ung
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Publication number: 20130336928Abstract: Methods for delivering therapeutic agent(s) to the central nervous system to treat a first CNS-related disease and/or condition while avoiding systemic exposure for patients having a second concurrent non-CNS-related disease and/or condition wherein the presence of the second disease and/or condition contraindicates systemic administration of the therapeutic agent(s) and/or pharmaceutical compound to treat the first disease or condition. The present invention provides these advantages by applying the therapeutic agent(s) and/or pharmaceutical composition(s) to the upper third of the nasal cavity, thereby bypassing the blood-brain barrier and administering the therapeutic agent(s) and/or pharmaceutical compound(s) directly to the CNS.Type: ApplicationFiled: June 13, 2013Publication date: December 19, 2013Inventors: Jacob F. Kobylecky, Benjamin B. Frey, William H. Frey, II