Acting On Peptide Bonds (3.4) (e.g., Urokinease, Etc.) Patents (Class 424/94.63)
Metalloproteinases (3.4.24) (e.g., collagenase, snake venom zinc proteinase, etc.) (Class 424/94.67)
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Patent number: 9907798Abstract: Methods of treating a head and neck cancer are disclosed.Type: GrantFiled: July 1, 2016Date of Patent: March 6, 2018Assignees: FOUNDATION MEDICINE, INC., UCL Business PLCInventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
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Patent number: 9901626Abstract: A method is disclosed to dissolve protein deposited in muscle. The method includes the step of administering an effective amount of an agent selected from the group consisting of fibrinolytics, proteolytics, photolytic and magnelytic agents.Type: GrantFiled: July 24, 2015Date of Patent: February 27, 2018Inventor: G. Blair Lamb
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Patent number: 9879246Abstract: The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.Type: GrantFiled: February 7, 2013Date of Patent: January 30, 2018Assignee: Grifols Therapeutics Inc.Inventors: Thomas P Zimmerman, Valery Novokhatny, Shan Jiang, James D Colandene
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Patent number: 9850500Abstract: The present invention relates to a recombinant adenovirus capable of regulating angiogenesis, which comprises (a) an adenoviral UR (inverted terminal repeat) nucleotide sequence; and (b) a transcription regulatory sequence for a VEGF-A (vascular endothelial growth factor-A) gene comprising (i) a nucleotide sequence encoding a DNA binding domain comprising a zinc finger domain to bind to a site in a VEGF-A promoter sequence as set forth in nucleotides 1-2362 of SEQ ID NO:1, and (ii) a transcription activation domain or a transcription inhibitory domain linked to the nucleotide sequence encoding the DNA binding domain; and a pharmaceutical composition comprising the recombinant adenovirus.Type: GrantFiled: May 30, 2006Date of Patent: December 26, 2017Inventors: Chae-Ok Yun, Joo-Hang Kim, Jin Soo Kim, Hyun Chul Shin, Yoon A Kang
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Patent number: 9797895Abstract: The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the composition according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.Type: GrantFiled: March 31, 2010Date of Patent: October 24, 2017Assignee: Leukocare AGInventors: Stefan Margraf, Anja Breuer, Martin Scholz, Jens Altrichter
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Patent number: 9757433Abstract: The present invention relates to modified angiotensin converting enzyme 2 (ACE2) polypeptides and pharmaceutical and analytical uses thereof. In particular, the present invention relates to Zn2+ depleted-, Zn2+ free-, mixed metal- and metal ion substituted-ACE2 as well as methods for the manufacture of these variants and uses thereof, such as therapeutic and analytic uses of these ACE2 variants.Type: GrantFiled: January 13, 2014Date of Patent: September 12, 2017Assignee: Apeiron Biologicals AGInventors: Hans Loibner, Bernhard Peball, Manfred Schuster, Stefan Stranner
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Patent number: 9636385Abstract: Provided is a method of treatment for reducing fibrosis involving administering purified collagenase into an anterior chamber of an eye of a human patient.Type: GrantFiled: October 24, 2013Date of Patent: May 2, 2017Assignee: The Research Foundation for The State University of New YorkInventor: Robert Honkanen
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Patent number: 9611467Abstract: This invention relates to methods of subcutaneous administration of ADAMTS13 formulations to a treat a disease or condition associated with ADAMTS13 and VWF dysfunction. Furthermore, evidence of the unexpectedly high bioavailability of ADAMTS13 formulations administered subcutaneously is provided herein.Type: GrantFiled: March 13, 2014Date of Patent: April 4, 2017Assignees: BAXALTA GMBH, BAXALTA INCORPORATEDInventors: Alexandra Nathalie Kopic, Werner Höllriegl, Barbara Plaimauer, Hanspeter Rottensteiner, Eva-Maria Muchitsch
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Patent number: 9605250Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.Type: GrantFiled: April 12, 2012Date of Patent: March 28, 2017Assignee: Gangagen, Inc.Inventors: Chemira B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan, Bharathi Sriram
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Patent number: 9572866Abstract: Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention. In addition, disclosed are vectors and host cells that include a nucleic acid encoding a polypeptide of the present invention, and kits that include pharmaceutical compositions of the present invention.Type: GrantFiled: July 17, 2015Date of Patent: February 21, 2017Assignee: Research Development FoundationInventors: Wylie W. Vale, Jr., Joan M. Vaughan, Cindy Donaldson, Wolfgang Fischer, Jean E. F. Rivier
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Patent number: 9517023Abstract: The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.Type: GrantFiled: May 27, 2010Date of Patent: December 13, 2016Assignee: Profusa, Inc.Inventors: William A. McMillan, Natalie Wisniewski
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Patent number: 9481713Abstract: The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix proteins, and methods of treatment comprising administering self-assembling peptides.Type: GrantFiled: April 28, 2014Date of Patent: November 1, 2016Assignee: Massachusetts Institute of TechnologyInventors: Yoshiyuki Kumada, Shuguang Zhang
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Patent number: 9381243Abstract: The present invention relates to compounds for treatment that protects the endothelium, prevents pathologic thrombus formation in the microcirculation and preserves platelet number and function and thus may be related to minimizing or preventing development of organ failure, including multiple organ failure (MOF), and, hence, death in critically ill patients by administration of agent(s) limiting the platelets ability to aggregate and form clots and/or by agents modulating/preserving endothelial integrity and/or by agent(s) increasing the rate of thrombus lysis, and Another aspect of the invention related to by a cell-based whole blood viscoelastical haemostatic assay identifying critically ill patients at increased risk of development of organ failure, including multiple organ failure (MOF) and death.Type: GrantFiled: July 11, 2014Date of Patent: July 5, 2016Assignee: RigshospitaletInventors: Pär Johansson, Sisse Rye Ostrowski
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Patent number: 9302027Abstract: A complex antimicrobial sorption composition possessing the necrolytic effect for treating the purulent wounds, the trophic ulcers, the wounds, and the infiltrates with the significant necrotic and exudative components represents the silica sorbent with the immobilized drug. Fine pyrogenic silica is used as a siliceous sorbent, and serrathiopeptidase as a drug.Type: GrantFiled: July 11, 2008Date of Patent: April 5, 2016Assignee: WILLINGSFORD LIMITEDInventors: Alexandr A. Golub, Olga O. Biliaieva, Viacheslav V. Neshta
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Patent number: 9255295Abstract: The invention relates to a method for evaluating the sensitizing potential of a test compound, and to a kit for implementing said method.Type: GrantFiled: March 7, 2011Date of Patent: February 9, 2016Assignee: IMMUNOSEARCHInventors: Hervé Groux, Françoise Cottrez
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Patent number: 9180159Abstract: The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor sequences, chimeric peptides, or of nucleic acids encoding same as well as pharmaceutical compositions containing same, for the treatment of non-chronic or chronic inflammatory digestive diseases, such as colitis, including e.g. Ulcerative colitis, Crohn's disease, diversion colitis, ischemic colitis, infectious colitis, fulminant colitis, chemical colitis, microscopic colitis, lymphocytic colitis, and atypical colitis, etc.Type: GrantFiled: June 2, 2009Date of Patent: November 10, 2015Assignee: Xigen Inflammation Ltd.Inventor: Christophe Bonny
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Patent number: 9089150Abstract: The present invention provides a method for lowering the feed conversion rate in a vertebrate comprising inhibiting the function of secreted protein acidic and rich in cysteine (SPARC), wherein the feed conversion rate is defined as the mass of the feed eaten divided by the body mass gain.Type: GrantFiled: May 27, 2011Date of Patent: July 28, 2015Assignee: NATIONAL CHENG KUNG UNIVERSITYInventors: Tzong-Yueh Chen, Yi-Ling Huang
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Patent number: 9084748Abstract: Provided are a folyl extract of fermented soybean (EFS) produced by fermenting a culture including a folic acid and soybean extract by using a microorganism, and a composition including the folyl EFS. The folyl EFS has an anti-histamine effect, an anti-allergic effect, a calcium-absorption-promotion effect, a bone-growth-promotion effect, a cell growth promotion effect, a collagen biosynthesis promotion effect, a wrinkle improvement effect, and an UV-induced cell damage inhibition effect. Accordingly, the folyl EFS can be used in a skin external application or cosmetic composition, a health supplement food composition, a feed composition, and a pharmaceutical composition.Type: GrantFiled: March 15, 2013Date of Patent: July 21, 2015Assignees: Damy Chemical Co., Ltd.Inventors: Kwang Nyeon Kim, Boo Sun Cho
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Patent number: 9066991Abstract: Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.Type: GrantFiled: December 22, 2010Date of Patent: June 30, 2015Assignee: LIFEBOND LTD.Inventors: Orahn Preiss-Bloom, Guy Tomer
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Patent number: 9056050Abstract: This invention relates to coated digestive enzyme preparations and enzyme delivery systems and pharmaceutical compositions comprising the preparations. This invention further relates to methods of preparation and use of the systems, pharmaceutical compositions and preparations to treat persons having ADD, ADHD, autism, cystic fibrosis and other behavioral and neurological disorders.Type: GrantFiled: April 13, 2009Date of Patent: June 16, 2015Assignee: CUREMARK LLCInventors: Joan Fallon, Matt Heil
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Publication number: 20150147308Abstract: Described herein are compositions which include digestive enzymes and which are formulated to reduce one or more symptoms of a neuropsychiatric disorder. Also described herein is a method for treating an individual with a neuropsychiatric disorder using digestive enzymes and their derivatives to alleviate the symptoms of neuropsychiatric disorders. The method comprises administering to the individual an effective amount of digestive enzymes that are either naturally or recombinantly derived, or their derivatives, in an amount effective to reduce one or more symptoms of the neuropsychiatric disorder.Type: ApplicationFiled: February 3, 2015Publication date: May 28, 2015Inventors: Joan M. Fallon, Matthew Heil, James Szigethy, James Fallon
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Publication number: 20150132280Abstract: A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.Type: ApplicationFiled: November 12, 2014Publication date: May 14, 2015Applicant: ORTHO-NUTRA, LLCInventors: Hector L Lopez, Shawn Wells, Tim N. Ziegenfuss
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Patent number: 9023344Abstract: A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and a method for preparing the therapeutic agent are disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic agent may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic agent may be made orally, through injection, by adherence of a medicated patch or by other methods. Further, a method of using the presence of chymotrypsin in the maternal GI tract as a biomarker, to determine the likelihood of developing preeclampsia, a pregnancy induced hypertension, and eclampsia/toxemia is disclosed.Type: GrantFiled: September 26, 2013Date of Patent: May 5, 2015Assignee: Curemark, LLCInventor: Joan M. Fallon
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Publication number: 20150118290Abstract: A method for reducing an established metastatic tumor, comprising administering an effective amount of a pharmaceutical composition to a subject in need, wherein the pharmaceutical composition comprises a polypeptide of a fibronectin-binding domain of dipeptidyl peptidase IV having a maltose-binding protein (MBP) fused at an N-terminal thereof, a cross-linking molecule, an active agent, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: October 22, 2014Publication date: April 30, 2015Applicant: NATIONAL CHENG KUNG UNIVERSITYInventors: HUNG-CHI CHENG, CHIEN-SHENG CHEN, YU-CHUAN LIN, CHIN-YUN CHENG, MING-MIN CHANG
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Publication number: 20150118154Abstract: The present invention relates to methods for the treatment, the prognosis and the diagnosis of non-small cell lung cancer.Type: ApplicationFiled: January 8, 2015Publication date: April 30, 2015Inventors: Marco Alifano, Patricia Forgez
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Patent number: 9017665Abstract: A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic agent may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic agent may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using of a biomarker, the presence of chymotrypsin in the gastrointestinal tract to determine the presence of symptoms of addiction, and the likelihood of relapsing into addiction is disclosed.Type: GrantFiled: June 25, 2013Date of Patent: April 28, 2015Assignee: Curemark, LLCInventor: Joan M. Fallon
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Patent number: 9017667Abstract: The therapeutic efficacy of zymogen proteins for oral administration is improved by including in the formulation one or more excipients that optimize pH and other reaction conditions for rapid activation of the zymogen shortly after ingestion.Type: GrantFiled: October 9, 2009Date of Patent: April 28, 2015Assignee: Alvine Pharmaceuticals, Inc.Inventor: Bret Berner
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Patent number: 8980254Abstract: Pharmaceutical formulations of orally administered proteins can be stabilized from oxidative degradation and inactivation in the stomach and GI tract by the addition of an antioxidant.Type: GrantFiled: August 21, 2009Date of Patent: March 17, 2015Assignee: Alvine Pharmaceuticals, Inc.Inventors: Matthew John Siegel, Bret Berner
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Patent number: 8974802Abstract: The invention relates to a suspension of red corpuscles encapsulating asparaginase as a medicament for treating pancreatic cancer. It in particular concerns a therapeutic composition or medicament intended for the treatment of pancreatic cancer, containing an effective quantity of such a suspension of red corpuscles.Type: GrantFiled: December 24, 2008Date of Patent: March 10, 2015Assignee: Erytech PharmaInventors: Emmanuelle-Cécile Dufour, Yann Godfrin
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Publication number: 20150064162Abstract: This invention relates to a method of marketing a gluten-digesting enzyme supplement comprising providing an effective amount of a gluten-digesting enzyme to a person desirous of maintaining or enhancing gastro intestinal comfort or delaying the onset of gastrointestinal discomfort; or desirous of reducing gluten exposure, and informing the gluten sensitive individuals of the ability to increase the efficacy of the supplement by drinking one serving of an acidic soft drink having a pH in a range from 2 to 3.5. Furthermore, it relates to a kit comprising a gluten-digesting enzyme supplement and instructions for use in combination with an acidic soft drink having a pH in a range from 2 to 3.5.Type: ApplicationFiled: September 4, 2014Publication date: March 5, 2015Inventors: Maaike Johanna BRUINS, Frits KONING, Veronica MONTSERRAT
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Publication number: 20150064163Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.Type: ApplicationFiled: September 2, 2012Publication date: March 5, 2015Applicant: LIFENET HEALTHInventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
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Patent number: 8951514Abstract: A composition and a method of treatment utilizing a combination of statins (or HMG-CoA reductase inhibitors), a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, with mixtures of an omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight including a combination of Eicosapentaenoic acid (EPA), Docosapentaenoic acid (DPA) and Docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from 5.7 to 6.3, wherein the sum of the EPA, DHA and DPA represent about 82% by weight of the total formulation and about 92% of the total omega 3 fatty acid content of the composition are taught.Type: GrantFiled: August 13, 2012Date of Patent: February 10, 2015Assignee: Pivotal Therapeutics Inc.Inventors: George Jackowski, Rachelle MacSweeney, Nisar Shaikh, Jason Yantha, Valerie Schini-Kerth
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Patent number: 8945602Abstract: A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.Type: GrantFiled: March 29, 2013Date of Patent: February 3, 2015Assignee: The Regents of the University of CaliforniaInventors: William Freeman, Michael J. Sailor, Lingyun Cheng, Frederique Cunin, Emily Anglin, Yang Yang Li
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Publication number: 20150023920Abstract: The invention includes a method of preventing or treating metastasis in a subject diagnosed with cancer, the method comprising determining whether at least one gene encoding one or more proteins is upregulated in a cancer tissue sample from the subject as compared to the level of expression of the at least one gene in a non-cancer control sample of the same tissue, and, if the at least one gene is upregulated in the cancer tissue sample from the subject, administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising one or more protein depleting agents.Type: ApplicationFiled: March 13, 2013Publication date: January 22, 2015Applicant: Drexel UniversityInventors: Alessandro Fatatis, Michael Russell, Qingxin (Cindy) Lui
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Publication number: 20150023949Abstract: Methods for treatment and diagnosis of pervasive developmental disorders in humans are described.Type: ApplicationFiled: March 5, 2013Publication date: January 22, 2015Inventors: Niven Rajin Narain, Paula Patricia Narain
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Publication number: 20150004153Abstract: A pest-combating composition including sodium lauryl sulfate and one or more of C6-12 fatty acids, preferably lauric and/or capric and/or caprylic acid, soy methyl ester, and 2-undecanone, and methods of combating pests utilizing same, are disclosed. The compositions can include a carrier oil such as silicon oil, soy methyl ester, or a vegetable oil, and can be in the form of an emulsion. The composition may be constituted as a spray composition, an aerosol, a lotion, a paste, or another compositional form. Pests that may be usefully combated with such composition include flying insects, including flies, mosquitoes, and wasps, ants, including arthropods such as fire ants, ticks, fleas, cockroaches, silver fish, thrips, gnats, aphids, Japanese beetles, and agricultural and horticultural arthropods and insects including beetles (potato and bean), flea beetles, fleahoppers, squash bugs, slugs, leaf hoppers, harlequin bugs, milk weed bugs, spiders, mites, lice, rodents, and deer.Type: ApplicationFiled: September 15, 2014Publication date: January 1, 2015Applicant: HOMS, LLCInventor: Allen Jones
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Publication number: 20140377217Abstract: Disclosed herein are compositions and methods for treating or preventing a cardiac arrhythmia in a subject.Type: ApplicationFiled: June 25, 2013Publication date: December 25, 2014Inventor: Robert G. Matheny
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Publication number: 20140377247Abstract: Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.Type: ApplicationFiled: February 7, 2014Publication date: December 25, 2014Applicant: Millennium Pharmaceuticals, Inc.Inventors: Bing-Yan ZHU, Penglie ZHANG, Lingyan WANG, Wenrong HUANG, Erick A. GOLDMAN, Wenhao LI, Jingmei ZUCKETT, Yonghong SONG, Robert M. SCARBOROUGH
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Publication number: 20140356345Abstract: The invention relates to a new family of proteolytic enzymes having the ability to hydrolize at a p H between 3 and 8 gluten olygopeptides which are resistant to cleavage by gastric and pancreatic enzymes and whose presence in the intestinal lumen results in toxic effects. The enzymes have been identified as endopeptidases of the S8/S53 family and are produced by an Actinoallomurus strain. The object of the invention includes also methods for producing enzymes composition comprising the endopeptidases by cultivation of native Actinoallomurus strains, mutants thereof, or recombinant host cells comprising nucleic acids codifying for the endopeptidases. Said nucleic acids constitute a further object of the invention.Type: ApplicationFiled: November 5, 2012Publication date: December 4, 2014Applicant: Fondazione Istituto Insubrico di Ricerca Per La VitaInventors: Linda Cavaletti, Lucia Carrano, Monica Abbondi, Mara Brunati, Anna Taravella
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Publication number: 20140356411Abstract: The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated.Type: ApplicationFiled: June 4, 2014Publication date: December 4, 2014Inventors: Donglei Fan, Xiaobin Xu
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Patent number: 8895047Abstract: Implantable catheters are provided which comprise an antimicrobial agent incorporated in a coating or bulk distributed, in combination with a fibrinolytic agent incorporated in a top coating.Type: GrantFiled: May 21, 2008Date of Patent: November 25, 2014Assignee: Arrow International, Inc.Inventors: Nisha Gupta, Joel Rosenblatt, Daniel J. Spangler
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Patent number: 8889128Abstract: The invention provides use of an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition mediated by IgG antibodies.Type: GrantFiled: December 12, 2007Date of Patent: November 18, 2014Assignee: Hansa Medical ABInventors: Lars Björck, Mattias Collin, Arne Olsén, Rikard Holmdahl, Kutty Selva Nandakumar, Oonagh Shannon
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Publication number: 20140335046Abstract: A method of inducing or promoting hair growth on the scalp of a subject, comprising the steps of (i) providing an ECM composition including at least one ECM material, (ii) administering inciting event means to a target skin location on the subject to induce an inciting event, and (iii) administering a therapeutically effective amount of said ECM composition to the target skin location. In some embodiments, the ECM composition includes at least one additional biologically active agent.Type: ApplicationFiled: September 19, 2013Publication date: November 13, 2014Inventor: Robert G. Matheny
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Patent number: 8883740Abstract: Compositions for regenerating tissue and wound repair, among other applications, are described.Type: GrantFiled: January 22, 2009Date of Patent: November 11, 2014Assignees: Fundacao de Amparoa Pesquisa do Estado de Sao Paulo-Fapesp, Biolab Sanus Farmaceutica Ltda.Inventors: Janaina De Souza Ventura, Linda Christian Carrijo Carvalho, Ana Marisa Chudzinski-Tavassi
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Patent number: 8883143Abstract: A method for selection and treatment of externally caused migraine headache, the method includes identifying a patient group having chronic migraine headache; determining the identified patient group, a specific patient with a post traumatic migraine headache; and administering to the selected patient by injection of a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmaceutically safe form to the selected patient's head or upper neck; administration preferably being on the sites of the trigeminal cervical system, enabling axonal transport of the neurotoxin from distal to central sites; and the administration preferably comprising extramuscular injection of the neurotoxin of suitable dilution (a) over the aponeurotic fascia to enable the neurotoxin to diffuse into distal sensory nerves, in order to concentrate the neurotoxin over the occipital-parietal-frontal head region, or (b) intra-orally, in a foramina of the sphenopalatine ganglion for enabling diffusion of the neurotoxType: GrantFiled: April 10, 2013Date of Patent: November 11, 2014Inventor: William J. Binder
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Publication number: 20140328818Abstract: Gluten-degrading proteases derived from insects, including flour beetles, are isolated, and the purified, and recombinant forms can be used to make gluten-containing food safe for patients suffering from gluten intolerance.Type: ApplicationFiled: March 30, 2012Publication date: November 6, 2014Applicant: ALVINE PHARMACEUTICALS, INC.Inventor: Pawan Kumar
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Publication number: 20140323930Abstract: The technology relates to the use of a proteolytic enzyme, for example hyaluronidase, for the treatment of abnormal protein collection in a patient's lymphatic system. In addition, the present technology provides a composition and a combined preparation each comprising hyaluronidase and at least one further proteolytic enzyme, and a method of prevention and/or treating primary or secondary edema in a patient in need thereof, wherein the patient is administered a therapeutically effective amount of hyaluronidase.Type: ApplicationFiled: April 29, 2014Publication date: October 30, 2014Applicant: Advanced Healthcare Consulting, LLCInventor: Doran Devon Edwards
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Publication number: 20140322226Abstract: Provided herein are methods of treatment of acute respiratory distress syndrome comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual in need thereofType: ApplicationFiled: March 14, 2014Publication date: October 30, 2014Applicant: QUESTCOR PHARMACEUTICALS, INC.Inventors: James KNIGHT, Steve CARTT, David YOUNG, Patrice BECKER
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Publication number: 20140322195Abstract: The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.Type: ApplicationFiled: October 24, 2012Publication date: October 30, 2014Inventors: Matthew Voss, Hiroki Sone, Samuel Chackalamannil, Munetaka Ohkouchi
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Patent number: 8871710Abstract: This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under physiological conditions. The compositions of one or more precursor proteins of growth factors of the GDF family provoke morphogenic effects such as growth, differentiation, protection and regeneration of a variety of tissues and organs, e.g. bone, cartilage, tendons, ligaments, nerves and skin. The compositions can be advantageously used for the healing of tissue-destructive injuries and for the prevention or therapy of degenerative disorders.Type: GrantFiled: December 20, 2012Date of Patent: October 28, 2014Assignee: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbHInventors: Jens Pohl, Frank Ploeger