Abstract: The use of psychoactive drugs as vaginal contraceptives is disclosed. The invention may be implemented by incorporating a psychoactive drug in a known method such as jelly, foam, or suppository introduction means prior to intercourse. Furthermore, the use of psychoactive drugs after intercourse using the above methods is disclosed.

Abstract: 1-Substituted imidazole derivatives exhibit spermatostatic and spermatocidal activity and are useful for contraceptive purposes both in male and female mammals.

Abstract: A contraceptive composition for vaginal administration which contains a salt of a sulfonated styrene polymer and a pharmaceutically acceptable carrier. Effective polymers have a degree of substitution of from about 0.7 to 1.3 and an average molecular weight of between 600 and 7,000,000.

Abstract: The use of 9-anthroylcholine by injecting or introducing such drug directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of introducing such drug are disclosed, such as by mixing such drug with jelly carriers, foam carriers, or paraffin oil.

Abstract: The use of N-(6 aminohexyl)-5-chloro-1-naphthalenesulfonamide, N-(6 aminohexyl)-5-chloro-2-naphthalenesulfonamide, or N-(6 aminohexyl)-5-bromo-2-naphthalensulfonamide by injecting or introducing such drugs directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of introducing such drugs are disclosed, such as by mixing such drugs with jelly carriers, foam carriers, or paraffin oil.

Abstract: The use of N-phenyl-1-naphthylamine by injecting or introducing such drug directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of introducing such drug are disclosed, such as by mixing such drug with jelly carriers, foam carriers, or paraffin oil.

Abstract: The use of 8-anilino-1-naphthalenesulfonate by injecting or introducing such drug directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of introducing such drug are disclosed, such as by mixing such drug with jelly carriers, foam carriers, or paraffin oil.

Abstract: Contraceptive method comprises maintaining in the genital tract of a female mammal a pyrazolone derivative in a concentration effective to inhibit the fertilization of ova. In addition to effectively inhibiting the enzymes or other sperm components necessary for conception, the compounds used in the method of the invention are advantageous in having low toxic, caustic or irritating properties, so that the contraceptive compositions are suitable for long-term use without adverse side-effects.

Abstract: Microcapsules laden with an active agent are prepared by a method comprising: (a) dissolving or dispersing an active agent in a solvent and dissolving a wall forming material in said solvent; (b) dispersing said solvent containing said active agent and wall forming material in a continuous-phase processing medium; (c) evaporating a portion of said solvent from said dispersion of step (b), thereby forming microcapsules containing said active agent in the suspension; and (d) extracting the remainder of the solvent from said microcapsules.

Abstract: The present invention relates to a novel local contraceptive method according to which the passage of spermatozoa in the cervical canal is prevented, the said method being characterized in that the physico-chemical structure of the cervical mucus is modified by means of at least one coagulating agent. It also concerns compositions for putting this novel method into effect, particularly compositions comprising at least one coagulating agent such as tannic acid. These compositions may also contain an agent which assists and completes the action of the coagulating agent.

Abstract: A vaginal contraceptive suppository having both a rapid release of active ingredient and prolonged duration of effectiveness. The suppository comprises a mixture of sodium starch glycolate, a thickening agent and a vegetable oil base combined with a spermicide.

Abstract: The use of psychoactive drugs by injecting or introducing such drugs directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of introducing such drugs are disclosed, such as by mixing such psychoactive drugs with jelly carriers, foam carriers, or paraffin oil.

Abstract: The use of crosslinked polysaccharides as vehicles for spermicidal substances in compositions used for local contraception is described. The crosslinked polysaccharide (e.g. a modified dextran) is admixed with the spermicidal agent and formed into tablets for vaginal applications; the dextran swells in contact with the vaginal secretion and includes the seminal liquid thus bringing into contact the sperm cells with the spermicidal substances dispersed therein.

Abstract: A gel formulation, which is inherently spermicidal and which provides an efficient delivery system for spermicidal and other contraceptively effective compounds intravaginally is disclosed. Said formulation is useful in methods of intravaginal contraception.

Abstract: A disposable non-woven sponge vaginal contraceptive device is made of alginic acid or related polysaccharides bearing carboxylic acid functionality and a method of making same is disclosed.

Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is phenyl optionally substituted with one or more substituents independently selected from the group consisting of lower alkyl, lower alkoxy, halo, or trifluoromethyl;Z is ethylene or propylene, optionally substituted with a single substituent which is lower alkyl;A is the integer 0, 1, 2, or 3;B is the integer 1, 2, or 3; andwherein the sum of A and B is 1, 2, 3 or 4; andthe pharmaceutically acceptable acid addition salts thereof, said compounds being useful as spermicidal, antimicrobial and anticonvulsant agents.

Abstract: The disclosed lubricating suppository is formulated to have properties advantageous for coital use, including extraordinary water washability. The ingredients and phase relationships of the suppository composition provide a high degree of compatibility with water and with naturally-occurring vaginal moisture. The suppository composition contains a glyceride lubricant and can be lubricious with or without the presence of moisture. The suppository, which is solid at room temperature but melts in a short time at body temperature, is made by dissolving, for example, 10-30 parts by weight of high-HLB (e.g. >14) nonionic surfactant in 50-70 parts by weight of a molten, water-soluble polyoxyethylene glycol component and by dispersing or emulsifying 10-20 parts by weight of the glyceride (e.g. a triglyceride of C.sub.6 -C.sub.18 aliphatic carboxylic acids) included in the composition.

Abstract: A spermicidally-active vaginal suppository consisting essentially of a solid water-soluble polymeric material which melts at body temperature, for example, a polyethylene glycol, having dispersed therein minor amounts of a spermicide, for example, p-nonylphenoxypolyethoxyethanol, a foaming agent operative when the suppository is dissolved in aqueous media to generate a foam-forming gas, for example, a mixture of a water-soluble bicarbonate and a solid weak acid, and a foam-stabilizing agent which is characterized by containing a surfactant, which is effective to reduce the surface tension of water to less than 45 dynes per centimeter, for example, sodium lauryl sulfate, and lactalbumin.

Abstract: A spermicidally active suppository comprising an alkylphenoxypolyethoxyethanol as the spermicide, a mixture of water-soluble polyethylene glycols as the suppository base, a mixture of an organic acid and an inorganic bicarbonate as the foaming agents and a mixture of an amphoteric surfactant and a water-soluble film-forming agent as the foam-stabilizing agent.

Abstract: The present invention relates to new and improved germicidal compositions having spermicidal properties comprising of a major amount of a mixture of n--C.sub.12-18 alkyl dimethyl benzyl ammonium halides and n--C.sub.12-14 alkyl dimethyl ethylbenzyl ammonium halides and a minor amount of a wetting agent selected from the group consisting of non-ionic, cationic and/or amphoteric surfactants and mixtures thereof.Spermicidal-germicidal compositions of the present invention possess new, improved and unexpected properties, particularly with respect to being biologically active against a wide range of organism including the venereal type organisms such as Neisseria gonorrhea, Treponema pallidum and other spirochetes, Hemophilus ducreyii, flagellates, such as Trichomonas vaginalis and related organisms. The compositions of the present invention have been found to exhibit spermicidal properties and, therefore, are particularly useful as a contraceptive. They are non-irritating towards vaginal tissues.

Abstract: A water-soluble complex comprising polyvinylpyrrolidone and gossypol is an effective spermicide.

Abstract: Hydrophobic substrate which can release at least one chemical substance, wherein it comprises a hydrophobic polymer matrix in which are homogeneously distributed inclusions of polymerized compounds of a different type to the said hydrophobic polymer and inclusions of the said substance, the polymerized compound inclusions forming in the said matrix a stable and continuous system in contact with the inclusions of the said substance.Process for the preparation of a hydrophobic substrate able to release a chemical substance, wherein it comprises forming inclusions of polymerized compounds in a hydrophobic polymer powder by grafting onto the latter a monomer of a different type to the said hydrophobic polymer, homogeneously mixing the grafted powder obtained in this way with a powder of the said substance and bringing the mixture into the form of a substrate by hot shaping it.

Abstract: This invention relates to the use of substituted 1-benzyl-1H-indazole-3-carboxylic acids to interrupt pregnancy. These compounds are described in the U.S. Pat. No. 3,895,026 assigned to the same assignee of the present patent application.

Abstract: The contraceptive consists of a spermicidal active substance of the formula RCONH--(CH.sub.2 CH.sub.2 O).sub.n --H, in which R denotes a C.sub.5 -C.sub.19 -alkyl or -alkenyl radical and n has a value of 3 to 20, a mixture of an alkali metal bicarbonate and a water-soluble, solid, anhydrous mono- or poly-carboxylic acid having 2 to 6 carbon atoms, in a stoichiometric ratio, as a foam generator, and a polyethylene glycol, or mixture of polyethylene glycols, which melts at body temperature.

Abstract: 1-Substituted imidazole derivatives exhibit spermatostatic and spermatocidal activity and are useful for contraceptive purposes both in male and female mammals.

Abstract: 1-Substituted imidazole derivatives exhibit spermatostatic and spermatocidal activity and are useful for contraceptive purposes both in male and female mammals.

Abstract: Disclosed is a method for treating mammalian spermatozoa with amphipathic amines in order to induce loss of fertility and/or head-tail cleavage of the sperms under mild physiological conditions. In the presence of primary alkyl or cycloalkyl amines containing between 4 to 7 carbon atoms at concentrations of about 15 .lambda./ml, sperms are rapidly dissociated into heads and tails under physiological pH- and temperature-conditions. Further disclosed are topical contraceptive compositions containing amphipathic amines.

Abstract: A synthetic physiological mucus having particular usefulness as a vaginal and surgical lubricant, based upon a pituitous aqueous solution of a high molecular weight polyacrylamide.

Abstract: A suppository especially adapted for vaginal insertion to act as a contraceptive which comprises a mixture of polyethylene glycol, a spermicidally-active ingredient, a thickening agent, an effervescent agent and alginic acid, the action of the alginic acid reacting with the effervescent agent in moist conditions to form carbon dioxide and also forming a viscous barrier adherent to the vaginal walls to prevent penetration of the sperm.

Abstract: In order to prolong the effectiveness of depot preparations of progestagens in an oily, unsaturated solution for intramuscular injection having long-term effectiveness sufficient for a desired purpose, the volume of the injection solution is increased such that the duration of the progestational activity is increased to at least 13 weeks while retaining the same quantity of active agent to be administered.

Abstract: A contraceptive containing device including a contraceptive gel having a pH of less than 3.0; an elongated casing containing the gel and having an insertion end extending beyond the gel; and a hygenically sealed pouch enclosing the casing. The seal at one end of the pouch overlaps the insertion end of the casing to secure the casing to the pouch and close the insertion end of the casing. The casing is weakened in a region near where it is secured to the pouch for tearing when the pouch is opened to expose the casing and the casing is pulled with respect to the overlapping end of the pouch so as to provide a shearing stress in the casing near the insertion end, for thereby separating the casing from the pouch.

Abstract: A spermicidal vaginal composition comprises a spermicidal-effective amount of a 1,2-benzisothiazole derivative having the general formula (I) ##STR1## wherein: X is either O or S;y is H; NO.sub.2 ; an halogen atom or an alkyl radical having from 1 to 4 carbon atoms; andR is H; a straight or branched alkyl or alkenyl radical having from 1 to 6 carbon atoms, optionally substituted by one or more hydroxyl, tertiary amino and alkoxyl groups; a cycloaliphatic radical having from 3 to 8 carbon atoms; an aryl radical optionally substituted by halogen atoms, alkyl or alkoxy radicals; an aralkyl radical optionally having the aromatic moiety substituted by halogen atoms, alkyl and alkoxyl radicals; or an acyl radical --COR' wherein R' is an alkyl group having from 1 to 4 carbon atoms or an aryl radical.

Abstract: The strong sexual excitants emitted by female animals when in heat and which serve to attract and arouse the male to mate are destroyed by treating with compounds containing chlorine dioxide in stable form. The compounds are non-irritating and are sufficiently effective when applied externally or internally so that a female in heat can be brought near a male of the same species without causing any appreciable change in the behavior of the male.