Abstract: The present invention relates to heavy metal chelate compositions, which are used as fungicides and bactericides, and methods of using the compositions. In particular, the present invention relates to a chelate, that is an EDDHA (copper-ethylenediamine-di-o-hydroxyphenylacetic acid), combined with a heavy metal, including iron, tin, zinc, manganese, copper, and combinations thereof.

Abstract: The present invention relates to genes and their encoded proteins which regulate neurite growth and the diagnostic and therapeutic use of such proteins (termed herein neurite growth regulatory factors). The proteins of the present invention include central nervous system myelin associated proteins and metalloproteases associated with glioblastoma cells and other malignant tumors which can metastasize to the brain. The metalloproteases of the invention have value in the treatment of nerve damage and of degenerative disorders of the nervous system. The present invention is also directed to inhibitors of the metalloproteases. Such inhibitors in combination with the CNS myelin associated inhibitory proteins can be used in the treatment of malignant tumors.

Abstract: The invention relates to novel cobalt compounds, having a general structure ##STR1## wherein Co is either Co(II) or Co(III), and each of the R groups is selected from the group consisting of hydrogen, alkyl, hydrophilic organic acid, alkyl amine, amine, alkyl alcohol, alcohol, polypeptide or nucleic acid. The invention further relates to methods of using such compounds to reduce the biological activity of proteins, particularly enzymes and zinc finger-containing proteins.

Abstract: A novel chelate complex allows the formation of stable solutions of molecular chlorine dioxide. The chelate complexes are composed of the electron-deficient chlorine dioxide molecule, which can accept an electron, and a chelating agent, which can contribute its available electrons to the accepting orbital of the chlorine dioxide molecule. Both active and passive methods of releasing the chlorine dioxide from such chelates by competitive displacement with selected metal cations are presented. In this manner a stabilized solution of molecular chlorine dioxide can be stored until needed and the chlorine dioxide released at time of use for cleaning, disinfection or other uses.

Abstract: Stable solid forms of preservative and embalming compositions are described which can be prepared by adding a sufficient amount of a chemical or chemicals containing at least one polar group capable of forming hydrogen and Van der Waal bonds with the reactive moieties of the aldehydes and antimicrobial agents in the preservative and embalming compositions. The amount of polar chemical(s) necessary to stabilize the reactive aldehydes and antimicrobial compounds/agents is based on a molar ratio of (i) polar groups in the stabilizing chemicals to (ii) reactive groups in the active preservative ingredient of at least 0.8.

Abstract: Cosmetic and/or dermatological compositions containing a non-photocatalytic metal oxide and tocopherol and, optionally, a metal-inactivating complexing agent are effective for inhibiting the light-induced peroxidation of lipids, and in particular lipids of sebaceous origin such as squalene.

Abstract: A skin treatment system comprises preparations for the topical application to the skin of histidine acting as a divalent cation chelator and exfoliant, pyridoxine and pantothenic acid and N-acetyl-D-glucosamine for increasing production of hyaluronic acid, superoxide dismutase and cysteine and vitamin E for decreasing the oxidative degradation of the hyaluronic acid, and pyroll carboxylic acid, or chemical salts thereof, and hyaluronic acid, or chemical salts thereof for providing increased hydration of the skin.

Abstract: This invention describes a process for the removal of exogenous minerals which have become attached to human hair or keratin fiber which include the steps of contacting at least one chelating agent to the human hair or keratin fiber, the chelating agent selected from the group consisting of amino acid-type, polyphosphate-type and phosphonate-type agents, maintaining contact with the chelating agent and the human hair or keratin fiber for a period of time sufficient to permit the chelating agent to complex with the exogenous minerals, thereby removing at least a portion of the attached minerals, and rinsing the chelating agent. The process is enhanced with the pH is adjusted to a range of between 4 to 9, preferably 5 to 8. The chelating agent is added at a concentration of 4% by weight to 25% by weight, preferably 5 to 20% by weight.

Abstract: Cosmetic product having a stabilized redox potential, comprising, in contact with one another, a cosmetic composition comprising, in an aqueous medium, a water-soluble metal salt, and the metal corresponding to this water-soluble metal salt. The stability of the redox potential of the cosmetic product of the present invention enables the properties of the cosmetic composition, in particular the physiological properties, to be exceptionally well preserved.

Abstract: A method for treating rhus dermatitis caused by exposure to urushiol is provided, comprising the step of topically applying a therapeutically effective amount of a soluble manganese salt to the affected area of the skin. The manganese compound penetrates the pores of the skin and acts a chelating agent on the urushiol molecule, deactivating its toxicity. A detoxification agent for urushiol is also provided, comprising a composition containing a soluble salt of manganese, such as an aqueous or alcohol solution, wherein the weight percent of manganese in said composition is a therapeutically effective amount, such as between 0.01% and 10.0% manganese. The detoxification agent is also useful as a means of preventing rhus dermatitis when applied to the skin in an appropriate base.

Abstract: The invention relates to a water-soluble complex formed between a chelating agent and manganese and pharmaceutical compositions thereof. The complex is a low molecular weight mimic of superoxide dismutase. The invention further relates to a method of using the complex comprising treating plant and animal cells with an amount of the complex sufficient to reduce or prevent superoxide radical-induced toxicity.

Abstract: The invention relates to a water-soluble complex formed between a chelating agent and manganese and pharmaceutical compositions thereof. The complex is a low molecular weight mimic of superoxide dismutase. The invention further relates to a method of using the complex comprising treating plant and animal cells with an amount of the complex sufficient to reduce or prevent superoxide radical-induced toxicity.

Abstract: A method for scavenging free iron or aluminum in fluids such as physiological fluids involves a provision in such fluids of a soluble polymer substrate having chelator immobilized thereon. According to the invention preferred such compounds comprise polysaccharides or proteins having a deferoxamine moiety thereon. Such a compound can be used for the treatment of iron overload, as well as to inhibit cell damage from oxidation/reduction reactions. In one embodiment, cell damage during reperfusion is inhibited, through provision of the chelating moiety at the site of reperfusion.

Abstract: A method of chelating a metal in solution comprise adding to the solution a safe and effective amount of an active form of CLA. Pharmaceutical preparations for practice of the method in vivo are disclosed.

Abstract: Particle emitting radionuclides, e.g. Samarium-153, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions and formulations for the therapeutic treatment of calcific tumors in animals.

Abstract: A Tc-99m mononuclide complex compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group and X is an anion, which is useful as a radioactive diagnostic agent for imaging of brain, cardiac muscle, pancreas or the like.

Abstract: Metal radionuclide labeled proteinaceous substances which contain, in their native states, disulfide (cysteine) linkages, which find use in diagnosis and treatment of a variety of pathologic conditions. The radionuclide labeled proteinaceous substances of the present invention are formed by the treatment of the proteinaceous substance of interest with a disulfide reducing agent, followed by reaction of the reduced proteinaceous substance ("H-treated product") with a suitable radionuclide species containing, for example, .sup.99m Tc, .sup.186 Re and .sup.188 Re, or .sup.67 Cu. It has been found that the H-treated products, e.g., antibodies, react specifically with radionuclide species to form stable radionuclide labeled antibodies or other radiolabeled products. The H-treated products may be stabilized or modified in a variety of ways prior to and subsequent to complexation with the metal radionuclide.

Abstract: A medical bandage product and method for continually administering a chelating agent through the skin of a living body in a controlled manner. The product includes a membrane of selected area adapted for placement against the skin, the membrane being formed of an aqueous solution release rate controlling material. An aqueous liquid impermeable member is connected about the edges of the membrane and having sides forming a reservoir. The aqueous solution consists essentially of a chelation agent in selected proportion, a transportation agent in selected proportion to the chelation agent, a pH adjustment agent in selected amount, and a vasodilator in selected proportion to the chelating agent and the balance water. Means for retaining the product against the skin is provided. Also discloses the method for transporting a chelating agent throughout body tissues with use of the product.

Abstract: Provided herein is a dietary food prepared mainly from brown algaes through treating them with acids for removing sodium ion which originally exists therein and neutralizing the thus obtained material with a solution containing an ion selected from the group of potassium, calcium, magnesium and iron to substitute any of the ions in the group for the removed sodium ion, and then making the resulting product into to a solid form.The thus obtained products exhibit a more favorable ion-exchange ability than natural seaweeds do and when they are taken into a living body, they act for decreasing or controlling the sodium content in the living body, consequently they can be used for the prevention of hypertension and cerebral apoplexy.The thus obtained products can be used for a dietary food for health by themselves and together with other foods. They can also be formulated to a composition form such as tablets, granules and pulvers in combination with conventional vehicles adopted in the art.

Abstract: A bleomycin conjugate for use in targeting a compound to a body tumor. The conjugate includes an oxidized bleomycin/cobalt(III) complex and the compound to be targeted joined to the complex through a monodentate cobalt/sulfur coordinate bond. Also disclosed are methods for preparing the conjugate, and for targeting the compound to a body tumor, for purposes of tumor radioimaging or therapy.

Abstract: The present invention discloses a group of calcium chelating compounds which have a descreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca.sup.2+ chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone. In a second form, the new compounds are comprised of a BAPTA-like chelator coupled to two 2-nitrobenzyl derivatives, themselves photochemical prcursors of the related 2-nitrosobenzophenones.The present invention also discloses a novel method for preparing 1-hydroxy- or 1-alkoxy-1-(2-nitroaryl)-1-aryl methanes. Methanes of this type are critical to the preparation of, or actually constitute, the photolabile Ca.sup.2+ chelating compounds disclosed and claimed herein.

Abstract: The invention provides a desalinating food suitable as an ingredient of diet for dietetic care of patients for whom decrease of the salt ingestion is essential. The inventive desalinating food is prepared by demetallizing the tissue of marine algae by treating with an inorganic acid followed by contacting thereof with an aqueous solution containing potassium ions to effect replacement therewith. The food can adsorb a large amount of sodium ions with simultaneous dispensation of potassium ions in the living body.

Abstract: Calcium 1-hydroxy-3-aminopropane-1,1-diphosphonate forms a gel when mixed with water. As compared to soluble salts of APD, the gel provides slow systemic release and reduced tissue damage when used in the treatment of certain disorders in warm blooded animals.

Abstract: Lipid Membrane Structures comprising Digalactosyl Diglyceride target the liver of humans and lower animals and are used to carry drugs to that organ, preferentially. Digalactosyl Diglyceride LMS containing insulin provide an effective means for treating diabetes mellitus. Digalactosyl Diglyceride LMS containing interferon are used to treat viral hepatitis.

Abstract: An agent for reducing the cholesterol level in the blood of a warm blooded animal comprises a plurality of vesicles prepared from a non-toxic, non-biodegradable, semi-permeable material, and a quantity of a bile acid sequestrant provided in liquid form. The liquid sequestrant is disposed within the vesicles in an amount by volume of up to ninety percent of the available internal volume of the vesicle. The vesicles selectively permit the ingress of bile acids, and may preferably possess an electrical charge on their outer surface to assist the passage of the bile acids therethrough.The present invention includes a method for reducing the cholesterol level in the blood, comprising administering the reducing agent. Oral administration is preferred, and, in one embodiment, the reducing agent comprising a plurality of the vesicles may be contained within a capsule or the like.

Abstract: The biocidal activity of N-(2-methyl-1-naphthyl)-maleimide is vastly improved by chelating it with an amine wherein each free hydrogen on each amino group has been replaced by the groups --(CH.sub.2).sub.n COOY wherein n represents 1 or 2 and each Y represents hydrogen, ammonium or an alkali metal cation.

Abstract: A cosmetic composition for removing eye makeup includes a mono- or di-alkyl or a mono- or di-alkenyl carboxylate of an .alpha.-methyl polyethoxylated glucoside in aqueous solution.

Abstract: There are disclosed methods and compositions for the controlled release of insecticides by using a mixture consisting of (a) an organopolysiloxane containing hydroxyl groups or functional groups which are hydrolyzable to hydroxyl groups, (b) a hydrolyzable organic titanium compound or a partial hydrolyzate thereof, and (c) a pesticide, e.g., an insecticide.

Abstract: There are disclosed methods and compositions for the controlled release of insecticides by using a mixture consisting of (a) a hydrolyzable silane or an organopolysiloxane containing hydrolyzable silane groups or partial hydrolyzates thereof, and (b) a pesticide, e.g., an insecticide.

Abstract: There are disclosed methods and compositions for the controlled release of insecticides by using a mixture consisting of (a) a hydrolyzable silane or an organopolysiloxane containing hydrolyzable silane groups or partial hydrolyzates thereof, (b) a hydrolyzable organic titanium compound or a partial hydrolyzate thereof, and (c) a pesticide, e.g., an insecticide.

Abstract: There are disclosed methods and compositions for the controlled release of insecticides by using a mixture consisting of (a) an organopolysiloxane containing hydroxyl groups or functional groups which are hydrolyzable to hydroxyl groups, (b) a hydrolyzable silane or an organopolysiloxane containing hydrolyzable silane groups or partial hydrolyzates thereof, (c) a hydrolyzable organic titanium compound or a partial hydrolyzate thereof, and (d) a pesticide, e.g., an insecticide.

Abstract: A method of transporting metal ions by introducing a metal complex into a medium containing a moiety which demands the metal ion and the complex releases the ions in a controlled manner upon demand. The metal complexes have an aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of hydrogen ion concentration. This dissociation property causes a controlled release of metal ion into mediums containing a reacting moiety upon demand for the metal ion. For example, metalworking emulsions of oil and water are stabilized by the addition thereto of minor amounts of a metal complex, e.g., disodium monocopper(II) citrate, which at alkaline pH metalworking conditions above about 7 to about 9 releases metal cations to the emulsions imparting stabilizing characteristics which prevent emulsion degradation by a number of factors commonly encountered in metalworking operations.

Abstract: There are disclosed methods and compositions for the controlled release of insecticides by using a mixture consisting of (a) an organopolysiloxane containing hydroxyl groups or functional groups which are hydrolyzable to hydroxyl groups, (b) a hydrolyzable silane or an organopolysiloxane containing hydrolyzable silane groups or a partial hydrolyzate thereof, and (c) a pesticide, e.g., an insecticide.

Abstract: A germicidal, disinfecting and antiseptic composition comprising alkoxy aliphatic amine derivatives of the formula (I) or (II) and an organic or inorganic compound capable of blocking metals. The composition can be used in germicides, disinfectants, cosmetics, domestic sundries and city water, and to remove the microbial pollution and other contamination problems in industrial processes.

Abstract: 1-(P-Benzenediazonium)-ethylenediaminetetraacetic acid is described. This material is a chelating agent which forms stable complexes with the ions of heavy metals including those having radioactive properties and also reacts readily and rapidly with biological molecules. The compound is a versatile reactive agent useful in introducing metal ions into biological molecules.

Abstract: Pyrrolidone-5,5-diphosphonic acids having the formula ##STR1## wherein R is a member selected from the group consisting of hydrogen and alkyl having from 1 to 6 carbon atoms; as well as their water-soluble salts. The pyrrolidone-5,5-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. They are stabilizers for percompounds and are useful in the delaying of the setting times for gypsum. In addition, the compounds are useful as cosmetic preparations such as toothpastes and mouthwashes where they prevent formation of tartar and plaque and are useful in therapy in the treatment of diseases related to the abnormal deposition or dissolution of difficultly soluble calcium salts in the animal body.

Abstract: Complexes of Cresolase and copper chelating agents are used for inhibiting L1210 mouse leukemia. Particularly effective complexes are the chelates of cresolase with 8-hydroxyquinoline, .alpha.,.alpha. dipyridyl, and hydroquinone. Tyrosinase obtained from the brown (Type I) common edible mushroom is a suitable source of cresolase. The cresolase active tyrosinase may then be reacted with copper chelating agent to produce the complex.

Abstract: Pyrrolidone-5,5-diphosphonic acids having the formula ##EQU1## wherein R is a member selected from the group consisting of hydrogen and alkyl having from 1 to 6 carbon atoms; as well as their water-soluble salts. The pyrrolidone-5,5-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. They are stabilizers for percompounds and are useful in the delaying of the setting times for gypsum. In addition, the compounds are useful as cosmetic preparations such as toothpastes and mouthwashes where they prevent formation of tartar and plaque and are useful in therapy in the treatment of diseases related to the abnormal deposition or dissolution of difficultly soluble calcium salts in the animal body.