Vector, Per Se (e.g., Plasmid, Hybrid Plasmid, Cosmid, Viral Vector, Bacteriophage Vector, Etc.) Bacteriophage Vector, Etc.) Patents (Class 435/320.1)
  • Patent number: 10287574
    Abstract: Transposomes and oligonucleotide replacement methods to make DNA libraries that have distinct 5? and 3? tags, and to make directional libraries that are enriched for a desired strand.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: May 14, 2019
    Assignee: ILLUMINA, INC.
    Inventors: Igor Goryshin, Bradley Baas, Ramesh Vaidyanathan, Mark Maffitt
  • Patent number: 10287559
    Abstract: The present invention provides PiggyBac transposase proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: May 14, 2019
    Assignee: Poseida Therapeutics, Inc.
    Inventors: Eric Ostertag, Blair Madison
  • Patent number: 10287607
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: May 14, 2019
    Assignee: Encoded Therapeutics, Inc.
    Inventors: Stephanie Tagliatela, Andrew Young, Szu-Ying Chen, Kartik Ramamoorthi, David Oberkofler
  • Patent number: 10287336
    Abstract: The present specification discloses erythropoietin receptor agonists, compositions and medicaments comprising such erythropoietin receptor agonists, methods and uses for such erythropoietin receptor agonists and compositions and medicaments, and methods and uses for erythropoietin receptor agonists and compositions and medicaments for treating an anemia.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: May 14, 2019
    Assignee: AskGene Pharma, Inc.
    Inventors: Jian-Feng Lu, Yuefeng Lu, Aijun Wang, Donggou He, Kurt Shanebeck, Chen Yao
  • Patent number: 10287608
    Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: May 14, 2019
    Assignee: Encoded Therapeutics, Inc.
    Inventors: Stephanie Tagliatela, Andrew Young, Szu-Ying Chen, Kartik Ramamoorthi, David Oberkofler
  • Patent number: 10288610
    Abstract: Provided are assays, kits and compositions for testing subjects, particularly asymptomatic subjects, to ascertain whether or not they are carriers of Salmonella enterica serotype Typhi. Methods for detecting the presence of Salmonella enterica serotype Typhi indicating molecules by a variety of methods such as immunoassays and mass spectrometry also are provided.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: May 14, 2019
    Assignees: THE GENERAL HOSPITAL CORPORATION, INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH (ICDDR,B), THE CHANGELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
    Inventors: Richelle Charles, Edward T. Ryan, Firdausi Qadri, Stephen Baker
  • Patent number: 10280179
    Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterized by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: May 7, 2019
    Assignee: HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
    Inventors: Marcus Conrad, Joel Schick, Bettina Proneth, Peter Sennhenn
  • Patent number: 10280466
    Abstract: This disclosure relates to methods and kits, systems for screening, diagnosing and prognosing a disease, disorder, or physiological state based upon temporal measurements and analysis of gene expression in a subject.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: May 7, 2019
    Assignee: Institute of Noetic Sciences
    Inventor: Garret L. Yount
  • Patent number: 10273515
    Abstract: The present invention relates to enzyme compositions and processes of producing and using the compositions for the saccharification of lignocellulosic material.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: April 30, 2019
    Assignee: Novozymes A/S
    Inventors: Jeffrey Shasky, Debbie Yaver, Donna Moyer
  • Patent number: 10271500
    Abstract: This invention provides an onion exhibiting very weak or no pungency and a method for producing such onion. In such onion, alliinase gene expression is reduced.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: April 30, 2019
    Assignee: HOUSE FOODS GROUP INC.
    Inventors: Masahiro Kato, Jinji Shono, Noriya Masamura, Shinsuke Imai, Yasuhiro Kamata
  • Patent number: 10273516
    Abstract: The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: April 30, 2019
    Assignee: Glycosyn LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Patent number: 10267804
    Abstract: Provided herein is a method of using transposition to improve methods of sequencing RNA molecules. Provided herein is a method of tagging nucleic acid duplexes, such as DNA:RNA duplexes or DNA:DNA duplexes. The method includes the steps of providing a transposase and a transposon composition, providing one or more nucleic acid duplexes immobilized on a support, and contacting the transposase and transposon composition with the one or more nucleic acid duplexes under conditions wherein the one or more nucleic acid duplexes and transposon composition undergo a transposition reaction to produce one or more tagged nucleic acid duplexes, wherein the transposon composition comprises a double stranded nucleic acid molecule comprising a transferred strand and a non-transferred strand.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: April 23, 2019
    Assignee: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Niall Anthony Gormley, Louise Fraser, Paula Kokko-Gonzales
  • Patent number: 10266858
    Abstract: The present invention relates to a microorganism of the genus Corynebacterium, which has an enhanced activity of aspartate ammonia-lyase and/or aspartate aminotransferase, and thus has an enhanced ability to produce L-arginine, and to a method of producing L-arginine using the microorganism of the genus Corynebacterium.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: April 23, 2019
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Hyun Ae Bae, Min Gyeong Kang, Han Hyoung Lee, Hye Won Kim, Sung Gun Lee
  • Patent number: 10266569
    Abstract: The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N0) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: April 23, 2019
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Centre National de le Recherche Scientifique (CNRS), Université Claude Bernard—Lyon 1, Ecole Normale Superieure de Lyon (ENS de Lyon), Université Grenobles Alpes
    Inventors: Viktor Volchkov, Marc Jamin, Philip Lawrence, Filip Yabukarski
  • Patent number: 10258653
    Abstract: Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: April 16, 2019
    Assignee: University Health Network
    Inventors: Jeffrey A. Medin, Christopher J. Paige
  • Patent number: 10261093
    Abstract: A method of detecting and isolating cells that produce a secreted protein of interest (POI), for example, an antibody, comprising: a) providing a eukaryotic cell comprising (i) a nucleic acid encoding the POI, and (ii) a nucleic acid encoding a cell surface capture molecule, which comprises a membrane anchor and is capable of binding the POI; (b) culturing the cell under conditions in which the POI and cell surface capture molecule are expressed, and a POI-cell surface capture molecule complex is formed intracellularly and displayed on the cell surface; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: April 16, 2019
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: James P. Fandl, Gang Chen, Neil Stahl, George D. Yancopoulos
  • Patent number: 10251936
    Abstract: The present invention relates to an EBV antigen specific T-cell receptor and the use thereof. Specifically, the present invention provides T cells specific for LMP1 of EBV using a T-cell receptor which is highly specific for specific epitopes derived from an EBV antigen, LMP1. In addition, the EBV antigen specific T-cell can be used in the prevention or treatment of EBV-associated diseases.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: April 9, 2019
    Assignee: The Catholic Unviersity of Korea Industry-Academic Cooperation Foundation
    Inventors: Tai Gyu Kim, Hyun Il Cho
  • Patent number: 10251937
    Abstract: Compositions, pharmaceutical compositions and biodegradable pharmaceutical compositions containing at least one analog of spadin or at least one analog of a propeptides of spadin or mixtures thereof are described. Methods for treating depression using the analogs of spadin or analogs of propeptides of spadin or mixtures thereof, as well as methods for blocking TREK-1 channel activity are also disclosed.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: April 9, 2019
    Assignees: MEDINCELL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Georges Gaudriault, Catherine Heurteaux, Jean Mazella, Marc Borsotto, Hamid Moha Ou Maati, Julie Veyssiere
  • Patent number: 10253323
    Abstract: This disclosure concerns compositions and methods for targeting peptides, polypeptides, and proteins to plastids of plastid-containing cells. In some embodiments, the disclosure concerns chloroplast transit peptides that may direct a polypeptide to a plastid, and nucleic acid molecules encoding the same. In some embodiments, the disclosure concerns methods for producing a transgenic plant material (e.g., a transgenic plant) comprising a chloroplast transit peptide, as well as plant materials produced by such methods, and plant commodity products produced therefrom.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: April 9, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Justin M. Lira, Robert Cicchillo, Carla N. Yerkes, Andrew E. Robinson
  • Patent number: 10244719
    Abstract: Disclosed is the seed of a novel soybean variety, designated 38G14B4189, a sample of which is deposited under ATCC Accession No. PTA-125136. Also disclosed are plants, or parts thereof, grown from the seed of the variety, plants having the morphological and physiological characteristics of the 38G14B4189 variety, and methods of using the plant or parts thereof in a soybean breeding program.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: April 2, 2019
    Assignee: Agrigenetics, Inc.
    Inventors: Robert E. Moore, Julian M. Lenis
  • Patent number: 10232014
    Abstract: The present invention relates to novel muteins derived from human tear lipocalin, which bind to IL 4 receptor alpha. The sequences of the muteins comprise particular combinations of amino acids. In particular a mutated amino acid residue is present at any one or more of the sequence positions 27, 28 30, 31, 33, 53, 57, 61, 64, 66, 80, 83, 104-106 and 108 of the linear polypeptide sequence of the mature human tear lipocalin. A mutated amino acid residue is also present at any 2 or more of the sequence positions 26, 32, 34, 55, 56, 58 and 63 of the linear polypeptide sequence of the mature human tear lipocalin. The invention also provides a corresponding nucleic acid molecule encoding such a mutein and a method for producing such a mutein and its encoding nucleic acid molecule.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: March 19, 2019
    Assignees: PIERIS PHARMACEUTICALS GMBH, ASTRAZENECA AB
    Inventors: Andreas Hohlbaum, Alexandra Baehre, Gabriele Matschiner, Stefan Trentmann, Klaus Kirchfeld, Hans-Juergen Christian
  • Patent number: 10233454
    Abstract: The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: March 19, 2019
    Assignee: DNA2.0, INC.
    Inventors: Jeremy Minshull, Mark Welch, Sridhar Govindrajan, Maggie Lee, Kate Caves, Jon Ness
  • Patent number: 10233455
    Abstract: The invention provides methods for identifying regenerated transformed plants and differentiated transformed plant parts, obtained without subjecting plant cells to selective conditions prior to regenerating the cells to obtain differentiated tissues. In particular embodiments, the plant cells are corn plant cells. Methods for growing and handling plants, including identifying plants that demonstrate specific traits of interest are also provided.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 19, 2019
    Assignee: Monsanto Technology LLC
    Inventor: Jyoti R. Rout
  • Patent number: 10231383
    Abstract: Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLAVATA3/ESR (CLE) peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: March 19, 2019
    Assignees: The Curators of the University of Missouri, Cornell University, North Carolina State University, Iowa State University Research Foundation, Inc., University of Georgia Research Foundation, Inc., The United States of America, as represented by the Secretary of Agriculture
    Inventors: Melissa G. Mitchum, Amy Replogle, Jianying Wang, Xiaohong Wang, Shiyan Chen, Ping Lang, Eric L. Davis, Thomas J. Baum, Richard S. Hussey
  • Patent number: 10231397
    Abstract: The present invention relates to a method of increasing resistance against fungal pathogens of the family Phacopsoraceae in plants and/or plant cells. This is achieved by increasing the expression of an EIN2 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells. Furthermore, the invention relates to transgenic plants, plant parts, and/or plant cells having an increased resistance against fungal pathogens, in particular, pathogens of the family Phacopsoraceae, and to recombinant expression vectors comprising a sequence that is identical or homologous to a sequence encoding an EIN2 protein.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: March 19, 2019
    Assignee: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Holger Schultheiss, Ralf Flachmann, Tobias Mentzel
  • Patent number: 10226020
    Abstract: A novel maize variety designated PH4358 and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH4358 with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH4358 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH4358 or a locus conversion of PH4358 with another maize variety.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 12, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Leonardus Johannes Maria Hendrickx, Tariq Mahmood
  • Patent number: 10227416
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: March 12, 2019
    Assignee: GENENTECH, INC.
    Inventors: Matthew Marrichi, Dorothea E. Reilly
  • Patent number: 10227603
    Abstract: The invention relates to plants as functional microRNA and/or functional siRNA vehicles, the preparation methods and uses thereof. In particular, disclosed in the present invention are plants or edible portions or extracts thereof as functional microRNA and/or functional siRNA vehicles and uses thereof. Also disclosed is a method for carrying the functional microRNA and/or functional siRNA, comprising the step of orally administering the plants or edible portions or extracts thereof to a subject in need thereof, wherein the plants or edible portions thereof express and carry the functional microRNA and/or functional siRNA vehicles, and the extracts contain the functional microRNA and/or functional siRNA.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: March 12, 2019
    Assignee: MICROMEDMARK BIOTECH CO., LTD.
    Inventors: Chenyu Zhang, Zhi Hong, Ke Zeng
  • Patent number: 10226021
    Abstract: A novel maize variety designated PH2TBY and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH2TBY with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH2TBY through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH2TBY or a locus conversion of PH2TBY with another maize variety.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 12, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventor: Lori Karyn Scott
  • Patent number: 10228380
    Abstract: Described herein are methods of identifying compounds that can modulate the transport of a steroid hormone across a phospholipid membrane. Also described herein are methods of identifying compounds that can affect the transcriptional activity of a steroid hormone nuclear receptor.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: March 12, 2019
    Assignee: The Regents of the University of California
    Inventors: Naoki Yamanaka, Sachiko Yamanaka, Naoki Okamoto, Riyan Bittar
  • Patent number: 10219461
    Abstract: A novel maize variety designated X18H535 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18H535 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18H535 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X18H535, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18H535. This invention further relates to methods for producing maize varieties derived from maize variety X18H535.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: March 5, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Joseph D Anderson, Terry R Colbert, Mark Jacob Gadlage, Daniel Preston Gorman, Thomas Russell Henry, Nathan Brook O'Berry, Jason Michael Prothro
  • Patent number: 10221237
    Abstract: The invention provides methods of using sequence based analysis and rational strategies to improve the solubility of immunobinders, and in particular of single chain antibodies (scFvs). The invention provides methods of engineering immunobinders, and in particular scFvs, by performing one or more substitutions with hydrophilic residues identified by analysis of a database of selected, stable scFv sequences. The invention also provides immunobinders with optimized solubility prepared according to the engineering methods of the invention.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: March 5, 2019
    Assignee: ESBATech, an Alcon Biomedical Research Unit LLC
    Inventors: Leonardo Borras, David Urech
  • Patent number: 10212959
    Abstract: The present invention provides a process for producing a food ingredient or beverage ingredient. The present invention also provides a process for producing food product or beverage product. The present invention also provides a process for providing starch, amylose, amylopectin, ?-glucan, fructan, non-starch polysaccharide, dietary fiber or resistant starch to improve one or more indicators of health in a mammal.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: February 26, 2019
    Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Zhongyi Li, Matthew Kennedy Morell, Stephen Alan Jobling
  • Patent number: 10215759
    Abstract: In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based medium-throughput electrophysiological assays for identifying human ENaC modulators, preferably ENaC enhancers. Compounds that modulate ENaC function in a cell-based ENaC assay are expected to affect salty taste in humans. The assays described herein have advantages over existing cellular expression systems. In the case of mammalian cells, such assays can be run in standard 96 or 384 well culture plates in high-throughput mode with enhanced assay results being achieved by the use of a compound that inhibits ENaC function, preferably an amiloride derivative such as Phenamil.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: February 26, 2019
    Assignee: SENOMYX, INC.
    Inventors: Guy Servant, Hong Chang, Cyril Redcrow, Sumita Ray, Imran Clark, Bryan Moyer
  • Patent number: 10214782
    Abstract: Embodiments of the invention provide a method of detecting one or more strains of Klebsiella pneumoniae. The method may include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the K. pneumonia genome that can provide definitive information to distinguish between one or more types or strains of K. pneumonia.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: February 26, 2019
    Assignees: The Translational Genomics Research Institute, Arizona Board of Regents on Behalf of Northern Arizona University
    Inventors: Jolene Bowers, Elizabeth Driebe, David Engelthaler, Paul Keim
  • Patent number: 10214746
    Abstract: The present disclosure relates in part to a method for identifying a soybean germline transformant from a population of soybean transformants by incorporating a selection agent within rooting medium used in tissue culture during the soybean transformation process. The soybean germline transformants are selected from a population of soybean transformants which are comprised of a combination of non-germline and germline soybean transformants. The soybean non-germline transformants are identified and eliminated early in the transformation process. The soybean germline transformants are identified and selected for culturing into mature soybean plants. The method is readily applicable for screening and obtaining a soybean germline transformant at an early stage in the soybean transformation process.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: February 26, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Sivarama Reddy Chennareddy, Dayakar Pareddy, Jayakumar Pon Samuel, Rodrigo Sarria-Milan, Toby Cicak
  • Patent number: 10208346
    Abstract: The present invention provides an epigenetic haemogram, also referred to as an epigenetic blood cell count that identifies the quantitative, comprehensive picture of cellular composition in a biological sample, wherein advantageously a normalization standard is used. The normalization standard is a nucleic acid molecule comprising at least one marker-region being specific for each of the blood cells to be detected, and at least one control-region being cell-unspecific, wherein said regions are present in the same number of copies on said molecule and/or a natural blood cell sample of known composition. Furthermore, the present invention relates to a kit and the use of a kit for performing the epigenetic assessment of comprehensive, quantitative cellular composition of a biological sample. The biological sample is derived from e.g.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: February 19, 2019
    Assignee: EPIONTIS GMBH
    Inventors: Sven Olek, Ulrich Hoffmueller
  • Patent number: 10208323
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: February 19, 2019
    Assignee: BASF SE
    Inventors: Hartwig Schroeder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • Patent number: 10202655
    Abstract: This invention relates to polynucleotide sequences encoding genes that can confer resistance to the plant pathogen Colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to the plant pathogen Colletotrichum, and processes of making said plants and seeds. The invention further presents sequences that can be used as molecular markers that in turn can be used to identify the region of interest in corn lines resulting from new crosses and to quickly and efficiently introgress the genes from corn lines carrying said genes into other corn lines that do not carry said genes, in order to make them resistant to Colletotrichum and resistant to stalk rot.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: February 12, 2019
    Assignee: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Karen E Broglie, Karlene H. Butler
  • Patent number: 10202467
    Abstract: Provided herein are methods and compositions for treating a subject suffering from a deficiency in ?-L-Iduronidase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an ?-L-Iduronidase. A therapeutically effective systemic dose is based on the specific CNS uptake characteristics of human insulin receptor antibody-?-L-Iduronidase fusion antibodies as described herein.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: February 12, 2019
    Assignee: ARMAGEN, INC.
    Inventors: William M. Pardridge, Ruben J. Boado
  • Patent number: 10202613
    Abstract: Methods and means are provided to produce positively charged oligosaccharides in the plant cell wall by introducing into said plant cell a Nodulation C protein fused to a heterologous Golgi signal anchor sequence.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: February 12, 2019
    Inventors: Frank Meulewaeter, Bartel Vanholme
  • Patent number: 10201135
    Abstract: A soybean cultivar designated S170013 is disclosed. The invention relates to the seeds of soybean cultivar S170013, to the plants of soybean cultivar S170013, to the plant parts of soybean cultivar S170013, and to methods for producing progeny of soybean cultivar S170013. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S170013. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S170013, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S170013 with another soybean cultivar.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: February 12, 2019
    Assignee: M.S. Technologies, LLC
    Inventor: Justin T. Mason
  • Patent number: 10202617
    Abstract: An expression cassette, wherein said expression cassette comprises: (a) an ie 1 promoter from white spot syndrome virus or a variant thereof; (b) a nucleic acid sequence encoding an N-terminal gp64 signal peptide or variant thereof, a nucleic acid sequence encoding an antigenic peptide, a nucleic acid encoding a transmembrane region, and a nucleic acid encoding a gp64 cytoplasmic region or variant thereof; in which the promoter is operably linked to the nucleic acid sequence.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: February 12, 2019
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Premanand Balraj, Hwei-Sing Jimmy Kwang, Anbu Kumar Karuppannan
  • Patent number: 10202612
    Abstract: The present disclosure relates, in some embodiments, to compositions, organisms, systems, and methods for expressing a gene product in a plant using a expression control sequence (ECS) operable in monocots and/or dicots. For example, (i) an isolated nucleic acid may comprise an ECS (e.g., a sugarcane bacilliform virus promoter) and, optionally, an exogenous nucleic acid (ExNA) operably linked to the ECS; (ii) an expression vector may comprise an ECS; an ExNA; and, optionally, a 3? termination sequence, wherein the ECS has promoter activity sufficient to express the ExNA in at least one monocot and at least one dicot; (iii) a microorganism, plant cell, or plant may comprise an isolated nucleic acid; (iv) a method for constitutively expressing an ExNA in a plant (e.g.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: February 12, 2019
    Assignee: The Texas A&M University System
    Inventors: Mona Damaj, T. Erik Mirkov
  • Patent number: 10195251
    Abstract: The present invention provides methods of treating a retinal disorder comprising administering an effective amount of a neurotrophic factor to a subject having the retinal disorder. The neurotrophic factors useful in the invention include mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF). The present invention further comprises pharmaceutical compositions and kits containing MANF and CDNF.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: February 5, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventor: Rong Wen
  • Patent number: 10188067
    Abstract: A novel maize variety designated X08M611 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X08M611 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08M611 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X08M611, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08M611 are provided. Methods for producing maize varieties derived from maize variety X08M611 and methods of using maize variety X08M611 are disclosed.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: January 29, 2019
    Assignee: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: Russell Fox, Elliot Lee Heffner, Gary Edward Henke, Sara Jane Lira, Leandro Daniel Perugini, Goran Srnic
  • Patent number: 10190124
    Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: January 29, 2019
    Assignee: Intrexon Corporation
    Inventors: Subba Reddy Palli, Mohan Basavaraju Kumar, Dean Ervin Cress, Ted Tsutomu Fujimoto
  • Patent number: 10182986
    Abstract: Described herein are methods of delivering a nanoparticle across the blood brain barrier to the brain of a subject by administering to the subject a nanoparticle having a nanoparticle core and a targeting agent. A variety of targeting agents may serve to promote delivery of the described nanoparticle.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: January 22, 2019
    Assignee: California Institute of Technology
    Inventors: Devin Wiley, Andrew Clark, Mark E. Davis
  • Patent number: 10183065
    Abstract: The invention provides a nucleic acid construct comprising a sequence that encodes a human telomerase reverse transcriptase (hTERT) protein which is devoid of telomerase catalytic activity and of a nucleolar localization signal. The construct is useful triggering an immune response in a subject, against cells that overexpress telomerase, preferably dysplasia cells or tumor cells.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: January 22, 2019
    Assignee: INVECTYS
    Inventors: Pierre Langlade Demoyen, Simon Wain-Hobson, Thierry Huet, Christelle Liard, Elodie Pliquet
  • Patent number: 10178837
    Abstract: The invention relates to the soybean variety designated 5PHQP31. Provided by the invention are the seeds, plants and derivatives of the soybean variety 5PHQP31. Also provided by the invention are tissue cultures of the soybean variety 5PHQP31 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 5PHQP31 with itself or another soybean variety and plants produced by such methods.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: January 15, 2019
    Assignee: MONSANTO TECHNOLOGY LLC
    Inventors: Craig K. Moots, David R. Wooten, Jr.