Vector, Per Se (e.g., Plasmid, Hybrid Plasmid, Cosmid, Viral Vector, Bacteriophage Vector, Etc.) Bacteriophage Vector, Etc.) Patents (Class 435/320.1)
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Patent number: 11926830Abstract: The present embodiments provide methods, compounds, and compositions for treating, preventing, or ameliorating a disease associated with dysregulation of the complement alternative pathway by administering a Complement Factor B (CFB) specific inhibitor to a subject.Type: GrantFiled: September 2, 2021Date of Patent: March 12, 2024Assignee: Ionis Pharmaceuticals, Inc.Inventors: Tamar R. Grossman, Michael L McCaleb, Andrew T. Watt, Susan M. Freier
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Patent number: 11926839Abstract: The present invention includes compositions and methods for T cell genome editing and screening in vivo. In certain aspects, the invention includes an sgRNA library for genome-scale mutagenesis.Type: GrantFiled: April 17, 2018Date of Patent: March 12, 2024Assignee: YALE UNIVERSITYInventors: Sidi Chen, Matthew Dong
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Patent number: 11920129Abstract: The present invention relates to ligation and/or assembly of nucleic acid molecules. Particularly, a double-stranded target nucleic acid having overhangs of at least one nucleotide is ligated with another nucleic acid molecule capable of forming a stem-loop structure with an overhang of at least one nucleotide. The invention is suitable for tagging nucleic acid molecules. In specific embodiments, the overhangs can be produced by chemical cleavage of phosphorothioate-modified nucleic acid molecules. The invention further relates to the amplification of the ligated product, and using the resultant amplicon for assembly of multiple nucleic acid fragments.Type: GrantFiled: October 24, 2018Date of Patent: March 5, 2024Assignee: National University of SingaporeInventors: Kang Zhou, Xiaoqiang Ma, Hong Liang
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Patent number: 11918000Abstract: The present disclosure relates to fungi, a culture filtrate thereof and a polysaccharide and their applications in inducing or priming plant resistance to viruses. Aspects of the present disclosure provides a cultured filtrate, derived from a fungus belonging to the genus Trichosporon, induces strong resistance to various viruses on different plants.Type: GrantFiled: June 5, 2019Date of Patent: March 5, 2024Assignee: ACADEMIA SINICAInventors: Hsin-Hung Yeh, Yi-Shu Chiu
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Patent number: 11898162Abstract: The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method.Type: GrantFiled: March 13, 2020Date of Patent: February 13, 2024Assignee: Wisconsin Alumni Research FoundationInventors: James A. Thomson, Junying Yu
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Patent number: 11891590Abstract: Provided is a detergent having a high detergency against corneum-derived stains and a method for evaluating the ability of an enzyme to degrade corneum-derived stains. The detergent a M23A subfamily protease as an active ingredient. The method for evaluating the ability of the enzyme to degrade corneum-derived stains comprises obtaining the degrading activities of the test enzyme on a reference peptide and one or more substrate peptides and evaluating the ability of the test enzyme to degrade corneum-derived stains based on the degrading activities of the test enzyme on the reference peptide and the substrate peptide, wherein the reference peptide is GGGGG or GGGG, the one or more substrate peptides are selected from the group consisting of GGGXG, GXGGG, GGXG, and GXGG, and X is any amino acid residue other than glycine.Type: GrantFiled: January 15, 2019Date of Patent: February 6, 2024Assignee: Kao CorporationInventors: Daichi Yamashita, Takahiro Hioki, Masatoshi Tohata
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Patent number: 11883480Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar, a cellulose derivative, a glycol or sugar alcohol, optionally an alkali or alkaline salt and an amino acid; and formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar of at least 150 mg/ml, a carrier, and optionally an alkali or alkaline salt and an amino acid.Type: GrantFiled: July 26, 2022Date of Patent: January 30, 2024Assignee: Merck Sharp & Dohme LLCInventors: Michael S. Ryan, Sherrie-Ann P. Martin, Jeffrey Thomas Blue, Heidi Joanne Pixley, Erin J. Green-Trexler, Lynne Ann Isopi
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Patent number: 11884938Abstract: The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.Type: GrantFiled: November 19, 2019Date of Patent: January 30, 2024Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Hyun Jung Kim
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Patent number: 11879124Abstract: A construction method of a regulation system for gene expression in Zymomonas mobilis and applications are provided. The T7 expression system in Zymomonas mobilis has been constructed. The T7 expression system is used to construct a regulation circuit, help analyze the function of toxic genes and realize the regulation of metabolic pathways in Zymomonas mobilis. At the same time, shuttle plasmids that can be used in Zymomonas mobilis and Escherichia coli, also be constructed to facilitate the construction of plasmid and improve the expression efficiency of foreign genes in Zymomonas mobilis, laying a foundation for subsequent protein expression and secretion and metabolic engineering pathway optimization regulation.Type: GrantFiled: May 10, 2023Date of Patent: January 23, 2024Assignee: Hubei UniversityInventors: Shihui Yang, Yi Wang, Yunhao Chen, Yueyue Chen, Qiaoning He
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Patent number: 11866705Abstract: Disclosed is an oligonucleotide or a pharmacologically acceptable salt thereof, wherein the oligonucleotide comprises at least one defined nucleoside structure, can bind to a human nSR100 gene and has human nSR100 expression inhibiting activity. The oligonucleotide has a length of 12 to 20 mer, and is complementary to a defined target region. Further, disclosed is an nSR100 gene expression inhibitor and a cancer therapeutic agent containing the oligonucleotide or the pharmacologically acceptable salt thereof. The cancer therapeutic agent is used for treatment of small cell lung cancer, prostate cancer, or breast cancer.Type: GrantFiled: July 31, 2019Date of Patent: January 9, 2024Assignees: Osaka Univerity, National Institutes of Biomedical Innovation, Health and Nutrition, Luxna Biotech Co., Ltd.Inventors: Masahito Shimojo, Satoshi Obika, Yuya Kasahara, Takao Suzuki, Masaki Yamagami, Tadashi Umemoto
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Patent number: 11866724Abstract: The invention relates to adenoviral vectors, cells for use in generating adenoviral vectors, methods for generating adenoviral vectors, and therapeutic uses of adenoviral vectors in gene therapy, tumour therapy and as vaccines.Type: GrantFiled: April 6, 2017Date of Patent: January 9, 2024Assignee: Gene Bridges GMBHInventors: Adrian Francis Stewart, Jun Fu, Anja Ehrhardt, Eric Ehrke-Schulz, Wenli Zhang
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Patent number: 11859221Abstract: The present invention relates to polypeptide having alpha-amylase activity. The present invention also relates to polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the polypeptides.Type: GrantFiled: June 30, 2022Date of Patent: January 2, 2024Assignee: Novozymes A/SInventors: Torsten Bak Regueira, Bitten Plesner, Thomas Holberg Blicher, Anne Dorte Houg, Sofia Arnehed, Lars Lehmann Hylling Christensen, Carsten Andersen
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Patent number: 11858998Abstract: The present invention provides methods for diagnosis, prognosis, prevention and/or treatment of cancers such as melanomas. The subject invention provides biomarkers and methods for assessing the severity of a cancer/tumor and for monitoring the progressing of a cancer/tumor. The subject invention also provides therapeutic targets in cancer for developing anti-cancer therapies.Type: GrantFiled: January 25, 2023Date of Patent: January 2, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Charles J. Dimitroff, Asmi Chakraborty
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Patent number: 11858965Abstract: The present disclosure relates to a recombinant protein comprising a plurality of type II cohesin repeats. The present disclosure provides a recombinant cellulosome complex comprising: the recombinant protein comprising a plurality of type II cohesin repeats; a recombinant cellulosome complex integrating protein A comprising a plurality of type I cohesin repeats, a plurality of cellulose-binding modules and a type II dockerin; and a plurality of recombinant enzymes each comprising a type I dockerin. A cell, a method for digesting a cellulose and a method for producing ethanol are also provided.Type: GrantFiled: May 21, 2021Date of Patent: January 2, 2024Assignee: ACADEMIA SINICAInventors: Wen-Hsiung Li, Anandharaj Marimuthu, Jui-Jen Chang, Yu-Ju Lin, Rizwana Parveen Rani Mohamed Gobil, Chieh-Chen Huang
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Patent number: 11839684Abstract: Disclosed is a mucoadhesive pharmaceutical composition comprising a poly-ionic complex of chitosan and a polyacrylic acid polymer. As an oral formulation, the composition has the extended retention time in the gastrointestinal tract by its mucoadhesive and swelling properties, which is useful as sustained release formulations, retentive formulations of active ingredients with limited absorption regions, and active ingredients with pH dependent solubility.Type: GrantFiled: July 29, 2021Date of Patent: December 12, 2023Assignee: SAMYANG HOLDINGS CORPORATIONInventors: Sang Yeob Park, Jong Won Yoon
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Patent number: 11837324Abstract: The technology disclosed relates to constructing a convolutional neural network-based classifier for variant classification. In particular, it relates to training a convolutional neural network-based classifier on training data using a backpropagation-based gradient update technique that progressively match outputs of the convolutional neural network-based classifier with corresponding ground truth labels. The convolutional neural network-based classifier comprises groups of residual blocks, each group of residual blocks is parameterized by a number of convolution filters in the residual blocks, a convolution window size of the residual blocks, and an atrous convolution rate of the residual blocks, the size of convolution window varies between groups of residual blocks, the atrous convolution rate varies between groups of residual blocks. The training data includes benign training examples and pathogenic training examples of translated sequence pairs generated from benign variants and pathogenic variants.Type: GrantFiled: October 15, 2018Date of Patent: December 5, 2023Assignee: Illumina, Inc.Inventors: Kishore Jaganathan, Kai-How Farh, Sofia Kyriazopoulou Panagiotopoulou, Jeremy Francis McRae
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Patent number: 11834635Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.Type: GrantFiled: April 19, 2021Date of Patent: December 5, 2023Assignees: Toyota Motor Corporation, Regents of the University of MinnesotaInventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
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Patent number: 11826409Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.Type: GrantFiled: May 14, 2021Date of Patent: November 28, 2023Assignee: IMMATICS BIOTECHNOLOGIES GMBHInventors: Andrea Mahr, Toni Weinschenk, Oliver Schoor, Jens Fritsche, Harpreet Singh, Phillip Mueller, Julia Leibold, Valentina Goldfinger
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Patent number: 11826384Abstract: Disclosed are methods of making a genetically modified immune cell for modifying a tumor microenvironment (TME) and methods of modifying a tumor microenvironment (TME). In some embodiments, the method can include delivering a first vector to an immune cell, wherein the first vector comprises a nucleic acid encoding a protein that induces T-cell proliferation, promotes persistence and activation of endogenous or adoptively transferred NK or T cells and/or induces production of an interleukin, an interferon, a PD-1 checkpoint binding protein, HMGB1, MyD88, a cytokine or a chemokine. Methods of modulating the suppression of the immune response in a tumor microenvironment, minimizing the proliferation of tumor and suppressive cells, and increasing the efficiency of an anti-cancer therapy, anti-infection therapy, antibacterial therapy, anti-viral therapy, or anti-tumoral therapy are also provided.Type: GrantFiled: November 25, 2019Date of Patent: November 28, 2023Assignee: Seattle Children's HospitalInventors: Courtney Crane, Michael C. Jensen, Kara White Moyes, Nicole Lieberman
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Patent number: 11819519Abstract: A therapeutic agent comprising a nucleic acid and a TCR modified immune cell and use thereof. The therapeutic agent comprises a first composition comprising a first active ingredient and a second composition comprising a second active ingredient. The first active ingredient includes or contains a nucleic acid having a labeling polypeptide coding sequence for being introduced into a tumor cell and/or a cancer cell. The labeling polypeptide has one or more epitope polypeptides which can be presented on a surface of the tumor cell and/or cancer cell by MHC class I molecules. The second composition comprises a second active ingredient in a second pharmaceutically acceptable carrier and the second active ingredient comprises a T cell receptor modified immune cell which can specifically recognize and bind to the epitope polypeptide presented by MHC class I molecules. The therapeutic agent achieves synergistic treatment effect and provides a new route for tumor treatment.Type: GrantFiled: August 26, 2019Date of Patent: November 21, 2023Assignees: HANGZHOU CONVERD CO., LTD.Inventors: Fang Hu, Yafei Hou, Jipo Sheng, Xiankui Tan
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Patent number: 11820792Abstract: The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.Type: GrantFiled: April 24, 2018Date of Patent: November 21, 2023Assignee: Imperial College Innovations LimitedInventors: Amin Hajitou, Keittisak Suwan, Mariam Albahrani, Sajee Waramit
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Patent number: 11814447Abstract: A peptide ligand specific for EphA2 comprising a polypeptide comprising three residues selected from cysteine, L-2,3-diaminopropionic acid (Dap), N-beta-alkyl-L-2,3-diaminopropionic acid (N-AlkDap) and N-beta-haloalkyl-L-2,3-diaminopropionic acid (N-HAlkDap), with the proviso that at least one of said three residues is selected from Dap, N-AlkDap or N-HAlkDap, the said three residues being separated by at least two loop sequences, and a molecular scaffold, the peptide being linked to the scaffold by covalent alkylamino linkages with the Dap or N-AlkDap or N-HAlkDap residues of the polypeptide and by thioether linkages with the cysteine residues of the polypeptide when the said three residues include cysteine, such that two polypeptide loops are formed on the molecular scaffold.Type: GrantFiled: June 18, 2019Date of Patent: November 14, 2023Assignee: BicycleRD LimitedInventors: Daniel Paul Teufel, Gemma Mudd, Silvia Pavan
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Patent number: 11814653Abstract: A heat attenuated infectious bronchitis virus (IBV) isolate of PDRC DMV/1639 deposited at the ATCC under Patent Designation PTA-126757 and progeny and derivatives thereof and compositions thereof are presented. Methods for administering the isolates and compositions as vaccines to prevent virulent IBV infection in birds of the order Galliformes are also presented.Type: GrantFiled: September 22, 2021Date of Patent: November 14, 2023Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Mark W. Jackwood, Brian J. Jordan
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Patent number: 11807868Abstract: The present disclosure provides a variant AAV capsid protein that confers tropism to lung cells and recombinant adeno-associated viruses comprising the variant AAV and pharmaceutical compositions comprising same and their use in the delivery of heterologous nucleic acids to lung cells for the treatment of pulmonary disorders.Type: GrantFiled: October 6, 2022Date of Patent: November 7, 2023Assignee: 4D Molecular Therapeutics Inc.Inventors: Melissa Kotterman, Peter Francis, Melissa Calton, Johnny Gonzales, Roxanne Croze, Christopher Schmitt
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Patent number: 11802293Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.Type: GrantFiled: October 16, 2020Date of Patent: October 31, 2023Assignees: KING'S COLLEGE LONDON, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAIInventor: Ralph Michael Linden
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Patent number: 11788079Abstract: The present invention relates to compositions comprising polypeptides having xylanase activity and polypeptides having arabinofuranosidase activity for use in, e.g., animal feed. The present invention further relates to polypeptides having arabinofuranosidase activity, polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: February 17, 2022Date of Patent: October 17, 2023Assignee: Novozymes A/SInventors: Ninfa Rangel Pedersen, Dan Pettersson, Jens Magnus Eklof, Soeren Nymand-Grarup, Lorena Gonzalez Palmen, Rune Nygaard Monrad, Wei Peng, Nikolaj Spodsberg, Mary Ann Stringer, Charlotte Blom, Lars Kiemer, Kristian Bertel Romer M. Krogh, Jesper Salomon
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Patent number: 11781144Abstract: Disclosed herein are pharmaceutical compositions and methods for inhibiting oxidative stress in a subject having atrial or ventricular arrhythmias, ventricular failure or heart failure. The methods include administering an effective amount of a NOX2 inhibitor agent to the subject, wherein said administering is under conditions such that a level of oxidative stress in myocardial tissue is reduced or eliminated. The pharmaceutical compositions include a NOX2 inhibitor agent.Type: GrantFiled: April 26, 2021Date of Patent: October 10, 2023Assignee: Northwestern UniversityInventor: Rishi Arora
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Patent number: 11781102Abstract: We have found a way to make possible large-scale plasmid transfection using PEI to produce high titer viral vectors in fixed bed or adherent cell culture bioreactors by using PEI as a transfection agent, while avoiding formation of the PEI-plasmid precipitate which in prior art approaches clogged adherent bioreactor substrates. We have also found a way to improve PEI-based transfection by modifying how pH and CO2 are managed during transfection.Type: GrantFiled: April 25, 2017Date of Patent: October 10, 2023Assignee: Trizell Ltd.Inventors: Hanna P. Lesch, Joonas Malinen, Eevi Lipponen, Anniina Valkama, Hanna Leinonen
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Patent number: 11771772Abstract: The present invention provides compositions and methods for lowering blood glucose. More specifically, the present invention provides compositions comprising a complex comprising IF and B12 conjugated to a peptide comprising a GLP-1 agonist. Advantageously, the composition may be delivered subcutaneously.Type: GrantFiled: April 26, 2021Date of Patent: October 3, 2023Assignees: Syracuse University, Xeragenx LLCInventors: Robert Doyle, Jonathan D. Bortz, David S. Hermelin
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Patent number: 11774442Abstract: The present described inventions relate, inter alia, to methods and compositions that provide for improved detection of target molecules.Type: GrantFiled: August 15, 2017Date of Patent: October 3, 2023Assignee: enEvolv, Inc.Inventors: James E. Spoonamore, Noah D. Taylor, Kristin J. Adolfsen, Matthew R. Dunn, Ilan N. Wapinski, Jay H. Konieczka
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Patent number: 11767534Abstract: The invention provides methods for determining the activity of a plurality of nucleic acid regulatory elements. These methods may facilitate, e.g., the systematic reverse engineering, and optimization of mammalian cis-regulatory elements at high resolution and at a large scale. The method may include integration of multiplexed DNA synthesis and sequencing technologies to generate and quantify the transcriptional regulatory activity of e.g., thousands of arbitrary DNA sequences in parallel in cell-based as says (e.g., mammalian cell based assays).Type: GrantFiled: May 4, 2012Date of Patent: September 26, 2023Assignee: THE BROAD INSTITUTE, INC.Inventors: Tarjei Mikkelsen, Andreas Gnirke, Alexandre Melnikov, Eric S. Lander, Li Wang, Xiaolan Zhang
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Patent number: 11760787Abstract: B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.Type: GrantFiled: December 9, 2019Date of Patent: September 19, 2023Assignee: Mayo Foundation for Medical Education and ResearchInventor: Lieping Chen
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Patent number: 11746359Abstract: The present invention relates to gene therapy delivery and expression systems comprising at least one helper-dependent adenoviral vector containing a nucleic acid sequence encoding for proteoglycan 4 (PRG4) or a biologically active fragment thereof. The invention further relates to a pharmaceutical composition comprising a therapeutically effective amount of at least one helper-dependent adenoviral vector containing said nucleic acid sequence encoding for proteoglycan 4 (PRG4), or a homolog thereof from any other species, or a biologically active fragment thereof. The invention also relates to the use of the novel gene therapy delivery and expression system according to the invention for use in the prevention and/or treatment of camptodactyly-arthropathy-coxa vara-pericarditis (CACP), or a musculoskeletal disorder such as a joint disorder or joint disease.Type: GrantFiled: April 1, 2022Date of Patent: September 5, 2023Assignee: Baylor College of MedicineInventors: Merry Ruan, Kilian Guse, Brendan Lee
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Patent number: 11746352Abstract: The present invention concerns nucleic acids of interest for modulating the microbiome of a host, to vectors encoding the nucleic acids and to methods for in vivo modulating the microbiome of a subject by delivering the nucleic acids of interest.Type: GrantFiled: December 29, 2021Date of Patent: September 5, 2023Assignee: Eligo BioscienceInventors: Jesus Fernandez Rodriguez, Xavier Duportet
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Patent number: 11739310Abstract: An amino acid sequence may have at least 70% sequence identity to the amino acid sequence identified in SEQ ID No. 1 over its entire length, and (a) an amino acid substitution on the position corresponding to the position 271, and (b1) at least one other amino acid substitution for at least one of the positions corresponding to the positions 18, 61, 92, 99, 137, 149, 156, 159, 162, 166, 172, 192, 199, 217, 265, or combinations thereof; and/or (b2) an amino acid substitution on the position corresponding to the position 9, and another amino acid substitution for at least one position corresponding to the positions 29, 48, 101, 130, 31, 133, 144, 217, 224, 252, or combinations thereof. Such proteases are useful for in washing or cleaning agents.Type: GrantFiled: September 5, 2018Date of Patent: August 29, 2023Assignee: Henkel AG & Co. KGaAInventors: Nina Mussmann, Susanne Wieland, Daniela Herbst, Inken Prueser, Christian Degering, Daria Strauss, Thorsten Eggert, Christian Leggewie, Layla Fernandez, Sabine Griemert
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Patent number: 11738079Abstract: The present disclosure relates to vaccines and methods for the prevention and treatment of Zika virus infection. Particularly, the present disclosure relates to viral and DNA vaccine vectors which includes or encode for secreted immunogenic peptides of NS1 that eliciting a protective immune response and prevent Zika virus infection of a subject.Type: GrantFiled: July 23, 2019Date of Patent: August 29, 2023Inventors: Eric James Gowans, Branka Grubor-Bauk, Danushka Wijesundara
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Patent number: 11732268Abstract: The present disclosure is in the field of plant transformation. The disclosure provides methods for increasing the rate of site-directed integration of a sequence of interest in plants. The disclosure also provides methods for increasing the efficiency of Rhizobiales-mediated plant transformation.Type: GrantFiled: June 27, 2017Date of Patent: August 22, 2023Assignee: Monsanto Technology LLCInventors: Elysia K. Krieger, Richard J. Lawrence, Zarir E. Vaghchhipawala, Jianping Xu, Xudong Ye
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Patent number: 11732269Abstract: The present disclosure provides maize B chromosome genomic loci and methods of using for agronomic practices.Type: GrantFiled: September 30, 2016Date of Patent: August 22, 2023Assignee: MONSANTO TECHNOLOGY LLCInventors: Randall Kerstetter, Jonathan C. Lamb, Thomas S. Ream, Shiaw-Pyng Yang, Xuefeng Zhou
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Patent number: 11732255Abstract: The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.Type: GrantFiled: January 15, 2021Date of Patent: August 22, 2023Assignee: 2seventy bio, Inc.Inventors: Jordan Jarjour, Kyle Havens, Anne-Rachel Krostag
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Patent number: 11732279Abstract: The disclosure discloses an Aspergillus niger engineered strain for reducing byproduct fumaric acid in a fermentation process of L-malic acid. The Aspergillus niger engineered strain is an Aspergillus niger engineered strain in which a fumarate hydratase gene fum is knocked out. The disclosure overcomes the defects in the prior art, in the current process of producing malic acid through fermentation of Aspergillus niger, byproduct fumaric acid can be accumulated with the generation of malic acid so as to cause the improved cost of the subsequent malic acid purification process. The disclosure provides an Aspergillus niger engineered strain in which a fum gene is knocked out and a method for greatly reducing byproduct fumaric acid in the fermentation production of Aspergillus niger.Type: GrantFiled: May 16, 2022Date of Patent: August 22, 2023Inventors: Hao Liu, Qing Xu
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Patent number: 11723987Abstract: Provided herein are recombinant expression vector systems for expression by stem cells that allow for selective elimination of stem cell-derived tumorigenic cells, while preserving stem cell-derived therapeutic cells. The systems provided herein provide a means by which modified stem cells can be safely transplanted into subjects. In exemplary embodiments, the system comprises at least two suicide genes, one of which is specifically inactivated in cells exhibiting the desired phenotype and one of which is activated when the cell comprising the recombinant expression vector system behaves similarly to or the same as a tumor cell.Type: GrantFiled: September 15, 2017Date of Patent: August 15, 2023Assignee: UNIVERSITY OF MIAMIInventor: Juan Dominguez-Bendala
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Patent number: 11725046Abstract: The invention describes fully native human neutralizing monoclonal antibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonal antibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and detection of Clostridium tetani infection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as possessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.Type: GrantFiled: December 28, 2018Date of Patent: August 15, 2023Inventors: Huaxin Liao, Yueming Wang, Xiaohui Yuan, Weihong Zheng
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Patent number: 11718862Abstract: This invention is directed to AAV compositions for circular RNA expression and methods of expressing covalently closed, circular RNA.Type: GrantFiled: October 20, 2021Date of Patent: August 8, 2023Assignee: The University of North Carolina at Chapel HillInventors: Aravind Asokan, Erin Borchardt, Rita Meganck, William F. Marzluff
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Patent number: 11713476Abstract: The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof.Type: GrantFiled: July 12, 2021Date of Patent: August 1, 2023Assignee: NOVOZYMES, INC.Inventors: Brett McBrayer, Tarana Shaghasi, Elena Vlasenko
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Patent number: 11712460Abstract: In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic complement-mediated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a Th17-associated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic respiratory system disorder. In some aspects, the invention provides methods of administering a complement inhibitor to a subject. In some embodiments, a method of treating a subject comprises administering multiple doses of a complement inhibitor to the subject according to a dosing schedule that leverages the prolonged effect of complement inhibition in chronic respiratory disorders. In some embodiments, a subject has chronic obstructive pulmonary disease. In some embodiments, a subject has asthma.Type: GrantFiled: April 20, 2021Date of Patent: August 1, 2023Assignee: Apellis Pharmaceuticals, Inc.Inventors: Cedric Francois, Pascal Deschatelets
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Patent number: 11701422Abstract: The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or variant thereof, which induces a T cell response, and a second polynucleotide encoding at least one protein, peptide or variant thereof, which induces an anti-pathogenic B cell response. The invention further relates to protein mixtures encoded by the expression system and cells comprising the expression system or the protein mixture and pharmaceutical compositions comprising the expression system or the protein mixture.Type: GrantFiled: February 25, 2020Date of Patent: July 18, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Alessandra Vitelli, Alfredo Nicosia, Riccardo Cortese
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Patent number: 11685710Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.Type: GrantFiled: August 11, 2021Date of Patent: June 27, 2023Assignee: The Board of Regents of The University of Texas SystemInventors: Daniel J. Siegwart, Jason B. Miller
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Patent number: 11685904Abstract: The present disclosure provides a replication-competent, recombinant oncolytic vaccinia virus, compositions comprising the vaccinia virus, and use of the vaccinia virus or composition for inducing oncolysis in an individual having a tumor.Type: GrantFiled: February 10, 2020Date of Patent: June 27, 2023Assignee: Ignite Immunotherapy, Inc.Inventors: David H. Kirn, Liliana Maruri Avidal, Prajit Limsirichai
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Patent number: 11679140Abstract: The present invention relates to the use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin for modulating cellular redox homeostasis. A particularly preferred use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin in the context of the present invention is as an antioxidant. The present invention also concerns a virally-mediated gene therapy for restoring genetically-impaired auditory and vestibular functions in subjects suffering from an Usher syndrome. More precisely, this gene therapy takes advantage of an AAV2/8 vector expressing at least one USH1 gene product, preferably SANS.Type: GrantFiled: July 27, 2020Date of Patent: June 20, 2023Assignees: INSTITUT PASTEUR, Centre National de la Recherche Scientifique (CNRS), Universite Clermont Auvergne, Sorbonne UniversiteInventors: Christine Petit, Paul Avan, Sedigheh Delmaghani, Jean Defourny, Asadollah Aghaie, Saaid Safieddine, Alice Emptoz
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Patent number: 11679156Abstract: The disclosure relates to a manufactured composition, material or device comprising at least two different nonradioactive isotope atoms. Each nonradioactive isotope atom is present in an amount sufficient to increase the total amount of the nonradioactive isotope atom above the total amount found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount. The ratio(s) of the at least two nonradioactive isotopes in the manufactured composition, material or device are measurably different than the ratio(s) found in the manufactured composition, material or device in the absence of adding the nonradioactive isotope atom to increase said total amount.Type: GrantFiled: November 1, 2018Date of Patent: June 20, 2023Assignees: American Air Liquide, Inc., Airgas, Inc., L'Air Liquide, Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges ClaudeInventors: Tracey Jacksier, Mani Matthew, Anthony W. Reccek, Jr., Martin Vasarhelyi, Vincent M. Omarjee