Vector, Per Se (e.g., Plasmid, Hybrid Plasmid, Cosmid, Viral Vector, Bacteriophage Vector, Etc.) Bacteriophage Vector, Etc.) Patents (Class 435/320.1)
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Patent number: 12290074Abstract: The present disclosure provides non-intergeneric remodeled microbes that are able to fix atmospheric nitrogen and deliver such to plants in a targeted, efficient, and environmentally sustainable manner. The utilization of the taught microbial products will enable farmers to realize more productive and predictable crop yields without the nutrient degradation, leaching, or toxic runoff associated with traditional synthetically derived nitrogen fertilizer. The remodeled microbes taught herein are able to be combined with leading agricultural chemistry and elite germplasm. Furthermore, the disclosure provides seed treatments comprising remodeled microbes.Type: GrantFiled: April 16, 2024Date of Patent: May 6, 2025Assignee: Pivot Bio, Inc.Inventors: Mark Reisinger, Ernest Sanders, Richard Broglie, Karsten Temme
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Patent number: 12290574Abstract: The disclosure includes CpG reduced regulatory elements, polynucleotides comprising such CpG reduced regulatory elements, expression cassettes comprising such CpG reduced regulatory elements, and recombinant AAV vectors comprising such CpG reduced regulatory elements. The regulatory elements can be, for example, operably coupled to a transgene.Type: GrantFiled: August 23, 2019Date of Patent: May 6, 2025Assignee: Spark Therapeutics, Inc.Inventors: Xavier Anguela, Liron Elkouby
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Patent number: 12286650Abstract: The purpose of the present invention is to provide a set of two polypeptides for use in light-dependent genetic recombination in which the N-terminal side fragment and the C-terminal side fragment of a Cre protein having an amino acid sequence of SEQ ID NO: 1 respectively bind to two proteins light-dependently forming a dimer.Type: GrantFiled: April 10, 2018Date of Patent: April 29, 2025Assignee: The University of TokyoInventor: Moritoshi Sato
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Patent number: 12286631Abstract: The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.Type: GrantFiled: March 6, 2024Date of Patent: April 29, 2025Assignee: The Medical College of Wisconsin, Inc.Inventors: Daniel M. Lipinski, Chris A. Reid
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Patent number: 12275927Abstract: Biomanufacturing hygiene control in batch and fed-batch bioreactors is provided using a bioreactor employing a chlorite/Cld system, wherein the bioreactor comprises an engineered cultured cell expressing a recombinant cytoplasmic chlorite dismutase (cCld) sufficient to increase chlorite resistance of the cell, and chlorite sufficient to substantially inhibit growth of one or more contaminating microorganisms in the bioreactor yet not substantially inhibit growth of the cell.Type: GrantFiled: May 5, 2022Date of Patent: April 15, 2025Assignee: The Regents of the University of CaliforniaInventors: John D. Coates, Ouwei Wang, Victor M. Reyes-Umana
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Patent number: 12275949Abstract: Disclosed herein are high transducing replication defective herpes simplex virus (HSV) vectors of McKrae strain.Type: GrantFiled: July 26, 2023Date of Patent: April 15, 2025Assignee: PeriphaGen, Inc.Inventors: David M. Krisky, James B. Wechuck, James R. Goss
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Patent number: 12270077Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids that have been fragmented with a transposase enzyme, alone or in combination with other types of analytes.Type: GrantFiled: July 6, 2023Date of Patent: April 8, 2025Assignee: 10x Genomics, Inc.Inventors: Michael Schnall-Levin, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Patrik Stahl, Jonas Frisen, Maja Marklund, Enric Llorens Bobadilla
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Patent number: 12268746Abstract: Polypeptides which can provide a senotherapeutic effect are provided herein. The polypeptides can be formulated for topical application and can be applied topically to a subject to provide a senotherapeutic effect in the subject or in the cells of the subject.Type: GrantFiled: July 22, 2020Date of Patent: April 8, 2025Assignees: OneSkin, Inc., Universidade Catolica de Brasilia, Uniao Brasileira de Educacao Catolica, BrasiliaInventors: Alessandra Zonari, Carolina Reis de Oliveira, Edgar Andres Ochoa, Juliana Lott de Carvalho, Lear Brace, Mariana Boroni, Mylieneth Guiang, Octávio Franco, William Farias Porto, Thuany de Alencar e Silva
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Patent number: 12268212Abstract: The present disclosure provides non-intergeneric remodeled microbes that are able to fix atmospheric nitrogen and deliver such to plants in a targeted, efficient, and environmentally sustainable manner. The utilization of the taught microbial products will enable farmers to realize more productive and predictable crop yields without the nutrient degradation, leaching, or toxic runoff associated with traditional synthetically derived nitrogen fertilizer. The remodeled microbes taught herein are able to be combined with leading agricultural chemistry and elite germplasm. Furthermore, the disclosure provides seed treatments comprising remodeled microbes.Type: GrantFiled: December 14, 2023Date of Patent: April 8, 2025Assignee: Pivot Bio, Inc.Inventors: Mark Reisinger, Ernest Sanders, Richard Broglie, Karsten Temme
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Patent number: 12268735Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.Type: GrantFiled: March 7, 2023Date of Patent: April 8, 2025Assignees: The Wistar Institute of Anatomy and Biology, The Trustees of the University of PennsylvaniaInventors: David Weiner, Ami Patel, Sarah Elliott
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Patent number: 12257266Abstract: Corneal stromal scars are the leading cause of corneal blindness. The present invention relates to methods and compositions useful in therapies for this pathological condition. The invention provides corneal stromal stem cells and certain other stem cells and as well as exosome polynucleotides produced by such cells, and methods for making and using these cells and compositions. The invention is based upon the discovery that exosomes and their associate active components obtained from these cells comprise agents having the same capacity as corneal stromal stem cells to reduce scarring and prevent scar formation in patients having corneal damage.Type: GrantFiled: March 4, 2019Date of Patent: March 25, 2025Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Sophie Xiaohui Deng, James L. Funderburgh
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Patent number: 12258590Abstract: The invention includes a mutant Taq polymerase, which can significantly extend and amplify a target sequence where the extension conditions are time limited to as little as one second. The mutant Taq polymerase, or a biologically active fragment thereof, has one or more substitutions differing from the wild type as shown in Table I.Type: GrantFiled: November 3, 2023Date of Patent: March 25, 2025Assignee: ABCLONAL SCIENCE, INC.Inventors: Zhenyu Zhu, Dapeng Sun
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Patent number: 12258593Abstract: The present invention provides a novel hydrolase that can industrially produce optically highly pure (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid with high efficiency at low costs, and a production method using the hydrolase.Type: GrantFiled: December 30, 2022Date of Patent: March 25, 2025Assignee: UBE CORPORATIONInventors: Toyokazu Yoshida, Koichi Ishida, Ryoma Miyake, Takanobu Iura, Hiroshi Kawabata
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Patent number: 12252690Abstract: According to a first aspect of the invention, a method for the generation of a cell line is provided, comprising the steps of (a) providing a plurality of mammalian B cells, wherein each of the plurality of B cells comprises a transgenic genomic DNA sequence encoding a marker protein inserted into an endogenous immunoglobulin locus comprised in said B cell, and wherein the transgenic genomic DNA sequence is amenable to cleavage by a site directed nuclease, particularly Cas9; (b) replacing the transgenic genomic DNA sequence encoding a marker protein with a second transgenic DNA sequence encoding a protein of interest; (c) sorting B cells based on the presence or absence of the marker protein; and (d) collecting B cells in which the marker protein is absent.Type: GrantFiled: June 5, 2023Date of Patent: March 18, 2025Assignee: ETH ZURICHInventors: Sai Reddy, William Kelton, Cristina Parola, Derek Mason, Mark Pogson
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Patent number: 12252719Abstract: Chimeric and other variant ?-glucuronidase enzymes with enhanced properties as compared to unmodified enzyme are provided. The enzymes of the invention advantageously exhibit enhanced enzymatic activity, enhanced substrate range, enhanced pH range, enhanced temperature range and/or enhanced enzyme stability. Methods of using the variant enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.Type: GrantFiled: July 14, 2022Date of Patent: March 18, 2025Assignee: INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC.Inventors: Caleb Reece Schlachter, John Tomashek, Lim Andrew Lee
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Patent number: 12241099Abstract: Peptide compounds derived from cathepsin G (CG), neutrophil elastase (NE), and cationic antimicrobial protein of 37 kDa (CAP37), and methods of their use in inhibiting and/or reversing polymerization of amyloid ? peptide into oligomers and/or fibrils, and/or disaggregating amyloid ? plaques, and methods of use of the peptide compounds in treatments of, for example, Alzheimer's disease, cerebral amyloid angiopathy, dementia, and/or neuroinflammation, and/or symptoms thereof are disclosed.Type: GrantFiled: December 8, 2020Date of Patent: March 4, 2025Assignee: The Board of Regents of the University of OklahomaInventors: Anne Kasus-Jacobi, Heloise Anne Pereira, Amanda J. Stock
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Patent number: 12234472Abstract: The present inventions provide eukaryotic cells, such as mammalian cells, that comprise adeno-associated virus (AAV) polynucleotides, including AAV capsid proteins (Cap), and are capable of expressing the polypeptides encoded by the AAV polynucleotides, and thereby are capable of producing AAV, including recombinant AAV. The eukaryotic cells also may comprise adenovirus (Ad) polynucleotides. The present inventions also provide methods of expressing AAV polynucleotides, as well as Ad polynucleotides, in eukaryotic cells, such as CHO cells, HEK 293 and BHK cells. The present inventions further provides other products and methods described herein.Type: GrantFiled: October 18, 2022Date of Patent: February 25, 2025Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Michael Goren, Yu Zhao, Alexandros Strikoudis, Darya Burakov, Gang Chen
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Patent number: 12227778Abstract: The invention relates to an in vitro cell-free expression system incorporating a novel inorganic polyphosphate-based energy regeneration system. In certain embodiments, the invention includes a cell-free expression system where the cellular energy source, ATP, is regenerated from inorganic polyphosphate using a dual enzyme system. In this embodiment, this dual enzyme system may include thermostable Adenosyl Kinase, and/or Polyphosphate Kinase enzymes.Type: GrantFiled: September 30, 2020Date of Patent: February 18, 2025Assignee: NATURE'S TOOLBOX, INC.Inventors: Alexander Koglin, Michael Humbert
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Patent number: 12221593Abstract: Bioactive coatings that include a base and a protein associated with the base for actively promoting the removal of organic stains are provided. In aspects, bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.Type: GrantFiled: November 21, 2023Date of Patent: February 11, 2025Assignees: TOYOTA MOTOR CORPORATION, REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Andreas Buthe, Ping Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Minjuan Zhang
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Patent number: 12221473Abstract: The disclosure provides engineered polypeptides that specifically bind to human complement component C5 and/or serum albumin. The disclosure also provides fusion proteins comprising such engineered polypeptides, wherein such fusion proteins may be multivalent and multi-specific fusion proteins. The disclosure further provides nucleic acid molecules that encode such engineered polypeptides or fusion proteins, and methods of making such engineered polypeptides or fusion proteins. The disclosure further provides pharmaceutical compositions that comprise such engineered polypeptides or fusion proteins, and methods of treatment using such engineered polypeptides or fusion proteins.Type: GrantFiled: October 7, 2022Date of Patent: February 11, 2025Assignee: Alexion Pharmaceuticals, Inc.Inventors: Bridget Puffer, Julian Chandler, Nimish Gera, Douglas L. Sheridan, Siddharth Jindal, Paul P. Tamburini
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Patent number: 12215345Abstract: Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using the compositions for inducing gene expression of mammalian genes.Type: GrantFiled: October 20, 2017Date of Patent: February 4, 2025Assignee: Duke UniversityInventors: Pablo Perez-Pinera, Charles A. Gersbach
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Patent number: 12209250Abstract: Provided herein are engineered HSV-1 vectors comprising a modified HSV-1 genome. The engineered HSV-1 vectors can be used to deliver genetic circuits (e.g., up to 100 kb) to cells in vitro or in vivo. Methods of treating or diagnosing a disease (e.g., cancer) using the engineered HSV-1 vectors described herein are also provided.Type: GrantFiled: January 14, 2020Date of Patent: January 28, 2025Assignee: Massachusetts Institute of TechnologyInventors: Ron Weiss, Maria Hottelet Foley, Jin Huh, Ross D. Jones
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Patent number: 12210557Abstract: An input of a data group is received in which tag ID-appended data and time information on time the tag ID-appended data was created are associated; the number of instances is counted of the tag ID-appended data, to which a tag identified by a tag ID has been appended, occurring in each time slice for each tag ID included in the tag ID-appended data and for each time slice obtained by dividing a timeline by a predetermined duration, and the tags are extracted as a few exuberant and useful minority tags in a case where the counted number of instances is greater than a predetermined instance number threshold value and where a ratio of the time slices in which the number of instances does not satisfy a predetermined criterion is greater than a predetermined ratio threshold value; and data in which a score satisfies a predetermined criterion is determined.Type: GrantFiled: February 22, 2022Date of Patent: January 28, 2025Assignee: HITACHI, LTD.Inventors: Ai Toshikuni, Tadahisa Kato, Yasunari Takai, Yasuto Nishiwaki
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Patent number: 12201682Abstract: The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Henipavirus, particularly Hendra virus and/or Nipah virus or a disorder related to such an infection. In particular, the present invention concerns a Hendra virus and/or Nipah virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.Type: GrantFiled: November 3, 2022Date of Patent: January 21, 2025Assignee: CureVac SEInventors: Edith Jasny, Benjamin Petsch
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Patent number: 12203123Abstract: This invention relates to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and recombinant nucleic acid constructs encoding Type I-E CASCADE complexes, plasmids, retroviruses and bacteriophage comprising the same, and methods of use thereof for screening for variant cells of an organism.Type: GrantFiled: September 25, 2019Date of Patent: January 21, 2025Assignee: North Carolina State UniversityInventors: Rodolphe Barrangou, Claudio Hidalgo Cantabrana
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Patent number: 12203071Abstract: The present invention relates to oligonucleotides which up-regulate or restore the expression of progranulin in cells, and their use in the treatment of neurological disorders, and disorders associated with progranulin haploinsufficiency.Type: GrantFiled: May 13, 2021Date of Patent: January 21, 2025Assignee: Hoffmann-La Roche Inc.Inventors: Ravi Jagasia, Lars Joenson, Søren Rasmussen, Disa Tehler, Dorthe Vang Larsen, Jesper Worm
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Patent number: 12195745Abstract: Methods and compositions for modulating the transduction efficiency of an adeno-associated vims (AAV) into a cell or tissue are provided.Type: GrantFiled: August 21, 2019Date of Patent: January 14, 2025Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.Inventors: Luk H. Vandenberghe, Amanda Dudek, Nerea Zabaleta Lasarte
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Patent number: 12195767Abstract: Disclosed herein are recombinant adeno-associated viral vectors expressing 21-hydroxylase (21OH) protein and related uses for treating 21OH deficiency.Type: GrantFiled: January 17, 2019Date of Patent: January 14, 2025Assignee: Adrenas Therapeutics, Inc.Inventors: Pierre Bougneres, Guangping Gao
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Patent number: 12188041Abstract: Provided herein are methods and compositions for expressing Otoferlin, e.g., utilizing adeno-associated viral (AAV) particles. Further provided herein are compositions of AAV particles comprising one or more polynucleotides encoding Otoferlin are codon optimized for expression in human cells. Such methods and compositions may be useful for treatment of diseases and disorders such as Deafness, Autosomal Recessive 9 (DFNB9). Also provided are kits comprising such compositions.Type: GrantFiled: November 1, 2019Date of Patent: January 7, 2025Assignee: University of Florida Research Foundation, IncorporatedInventors: Frank M. Dyka, William W. Hauswirth
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Patent number: 12188018Abstract: Compositions and methods for binding to a target sequence of interest are provided. Compositions include fusion proteins between DNA binding proteins or protein domains and nucleic acid modifying proteins or protein domains. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, deaminases, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs. Also provided are deaminases which may be fused to a DNA-binding polypeptide and may be useful for gene editing.Type: GrantFiled: May 12, 2023Date of Patent: January 7, 2025Assignee: Life Edit Therapeutics, Inc.Inventors: Tyson D. Bowen, Alexandra Briner Crawley, Tedd D. Elich, Mark Moore, Michael Lassner
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Patent number: 12188036Abstract: The present invention relates to an expression cassette for a target protein, comprising a promoter, a polynucleotide coding for the target protein, an intron sequence, and a poly A sequence, an expression vector, and a transformant. The expression cassette for a target protein according to the present invention can simultaneously perform the expression of the intron sequence and the target protein through one transduction and exhibits the effect of inducing the high expression and high functionality of the target protein by regulating the expression of an endogenous gene.Type: GrantFiled: October 11, 2018Date of Patent: January 7, 2025Assignee: CELLTRION INC.Inventors: Man Su Kim, Min Soo Kim, Jong Moon Cho, Shin Jae Chang
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Patent number: 12186388Abstract: The present invention relates to universal sarbecovirus vaccines that specifically express an interferon. This live universal sarbecovirus vaccine elicits mucosal immunity and heterotypic immunity against various sarbecoviruses, including SARS-CoV-1, SARS-CoV-2, and its variants. Interferon directly encoded from the genome of the live universal sarbecovirus overrides the virus-induced “delayed type-I interferon”, resulting in enhancement of mucosal T cell responses. The present invention further relates to uses of the vaccines for the preparation of pharmaceutical compositions, methods of treating or preventing viral infections, and kits comprising the vaccines.Type: GrantFiled: February 6, 2023Date of Patent: January 7, 2025Assignee: CENTRE FOR VIROLOGY, VACCINOLOGY AND THERAPEUTICS LIMITEDInventor: Kin Hang Kok
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Patent number: 12173041Abstract: Methods of treating a cancer in a patient are provided. The methods can include obtaining a tumor sample from a patient, detecting whether CCNG1 gene expression is present in the tumor sample, diagnosing the patient with a CCNG1 inhibitor-responsive cancer when the presence of CCNG1 gene expression in the tumor sample is detected, and/or administering an effective amount of a CCNG1 inhibitor to the diagnosed patient. CCNG1 inhibitors can include a viral vector having a binding peptide that is configured to bind one or more signature (SIG) elements of an invading tumor and at least one cytocidal gene. CCNG1 inhibitors including cell penetrating peptides are also provided.Type: GrantFiled: April 5, 2022Date of Patent: December 24, 2024Assignee: Delta Next-Gene, LLCInventors: Erlinda M. Gordon, Frederick L. Hall
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Patent number: 12171196Abstract: Monitoring of animals in a herd has various challenges. A method and a system for monitoring and measuring the behavior of a plurality of animals in a herd chamber is provided. The disclosure provides a method to develop a model to identify the animal interactions between a given set of herds of two or more animals. The system uses image, RFID sensors, animal phenotyping information such as species, breed, age and reproduction cycle information to generate an animal profile. This profile is used to quantify the interaction into an aggression score to the animals in the given herd. The aggression score over a given duration can help herd manager to put the animals with similar aggression score together. This will also help analyze the temporal aspects of the aggression score for a given animal and take preventive measures.Type: GrantFiled: May 16, 2022Date of Patent: December 24, 2024Assignee: TATA CONSULTANCY SERVICES LIMITEDInventors: Vaibhav Sadashiv Lonkar, Dinesh Kumar Singh, Karthik Srinivasan, Shubhadra Varma Pusapati, Saibhargavi Gurram, Jayantrao Mohite, Sanat Sarangi, Srinivasu Pappula, Suryakant Ashok Sawant
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Patent number: 12171808Abstract: The invention relates to a fusion protein comprising a main protein and one or more extension peptides, wherein the amino acid sequence of the main protein is identical or similar to the amino acid sequence of a mammalian protein or a fragment thereof, and said extension peptide comprises a cluster of O-glycosylated amino acids. The extension peptide is identical to a non-repeated sequence of the mammalian protein and/or identical or similar to SEQ ID NO: 1. The main protein is preferably VWF. The fusion protein has an increased half life as compared to the main protein and may be used to increase the half-life of a binding partner, e.g. FVIII. The invention further relates to the complex formed by the fusion protein, a polynucleotide encoding the fusion protein as well as a vector and host cell comprising the polynucleotide.Type: GrantFiled: April 26, 2017Date of Patent: December 24, 2024Assignee: OCTAPHARMA AGInventors: Christoph Kannicht, Barbara Solecka-Witulska, Stefan Winge, Tilo Schwientek
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Patent number: 12173300Abstract: The invention relates to methods of producing a desired phenotype in a plant by manipulation of gene expression within the plant. The method relates to means which increase the level of expression of a MYB-subgroup14 polynucleotide or a MYB68 polypeptide. The method also relates to expression of a nucleic acid sequence encoding a MYB-subgroup14 or a MYB68 transcriptional factor. The methods are directed to elevating the levels of a MYB-subgroup14 or a MYB68 expression, wherein a desired phenotype such as reduced flower abortion and increased yield during heat stress is observed. The invention also relates to nucleic acid sequences useful in such methods.Type: GrantFiled: August 25, 2021Date of Patent: December 24, 2024Assignee: Performance Plants Inc.Inventors: Jiangxin Wan, Yafan Huang, Monika M. Kuzma
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Patent number: 12168771Abstract: The invention provides recombinant DNA molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising the recombinant DNA molecules operably linked to heterologous transcribable DNA molecules. Also provided are methods of the use of the recombinant DNA molecules and constructs and the transgenic plants, plant cells, plant parts, and seeds comprising the recombinant DNA molecules and constructs.Type: GrantFiled: August 11, 2022Date of Patent: December 17, 2024Assignee: Monsanto Technology LLCInventors: Jaishree M. Chittoor, Stanislaw Flasinski
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Patent number: 12161702Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.Type: GrantFiled: June 17, 2021Date of Patent: December 10, 2024Assignee: Takeda Pharmaceutical Company LimitedInventors: Farah Natoli, Gaozhong Zhu, Jennifer Terew, Yuan Jiang, Jamie Tsung, Zahra Shahrokh, Brian Vernaglia, Jing Pan, Richard Pfeifer, Pericles Calias
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Patent number: 12163170Abstract: The present invention relates to a microorganism with increased carbon monoxide availability and use thereof.Type: GrantFiled: October 11, 2022Date of Patent: December 10, 2024Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Byung-Kwan Cho, Sangrak Jin, Seulgi Kang, Jiyun Bae, Hyeonsik Lee
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Patent number: 12156911Abstract: Vaccine compositions comprising a single KSHV-LP comprising two or more KSHV glycoproteins and/or one or more T cell antigens and methods of preventing or treating KSHV infections using the vaccine compositions. An expression system or a single expression vector for co-expressing two or more KSHV glycoproteins simultaneously to generate a vaccine comprising a single virus-like particle. The expression system may include a single plasmid inserted with two or more nucleic acid sequences that encode two or more KSHV glycoproteins linked by one or more linking sequences such that the KSHV glycoproteins are co-expressed simultaneously.Type: GrantFiled: February 21, 2020Date of Patent: December 3, 2024Assignee: CITY OF HOPEInventors: Javier Gordon Ogembo, Lorraine Zvichapera Mutsvunguma, David H. Mulama, Murali Muniraju, Felix Wussow
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Patent number: 12157762Abstract: Disclosed are nucleic acids and polypeptides which provide the co-expression of interleukin (IL)-21 and IL-15 by a host cell, each interleukin being bound to the cell membrane by a cell membrane anchor moiety. Also disclosed are related recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.Type: GrantFiled: May 2, 2023Date of Patent: December 3, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Christian S. Hinrichs, Benjamin Y. Jin
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Patent number: 12152261Abstract: The present invention relates to a method for reducing fructan in a fructan-containing food product, including adding an invertase belonging to enzyme classification EC 3.2.1.26 to the food product, and incubating the food product with the invertase, wherein fructan in the fructan-containing food product is hydrolysed. The invention further relates to the use of an invertase belonging to enzyme classification EC. 3.2.1.26 for the preparation of a medicament or a dietary supplement for the treatment of a person suffering from irritable bowel syndrome. Invertase (EC 3.2.1.26) may optionally by further combined with inulinase (EC3.2.1.7) and/or beta-fructosidase (EC 3.2.1.80).Type: GrantFiled: February 18, 2020Date of Patent: November 26, 2024Assignee: DSM IP Assets B.V.Inventor: Petrus Jacobus Theodorus Dekker
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Patent number: 12150987Abstract: In one embodiment, an expression system for expressing a UL128 complex is provided herein. The expression system may include a bacterial artificial chromosome (BAC) construct, wherein the BAC construct comprises a viral vector inserted with a set of DNA sequences that encode a UL128 complex. In another embodiment, a vaccine composition for preventing HCMV infection is provided. The vaccine composition may include a viral or bacterial vector capable of expressing a UL128 complex and a pharmaceutically acceptable carrier, adjuvant, additive or combination thereof or additional vector expressing a protein adjuvant. The viral vector may be an MVA and the UL128 complex includes five HCMV proteins or antigenic fragments thereof: UL128, UL130, UL131A, gL, and gH. In some embodiments, the viral vector is further inserted with one or more additional DNA sequences that encode one or more additional HCMVHCMV proteins or antigenic fragments thereof such as pp65, gB or both, or such as gM/gN or gO.Type: GrantFiled: June 13, 2023Date of Patent: November 26, 2024Assignee: CITY OF HOPEInventors: Don J. Diamond, Felix Wussow
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Patent number: 12146174Abstract: The present invention provides a mutated histidine decarboxylase suitable for a practical use. Specifically, the present invention provides a mutated histidine decarboxylase having at least one amino acid residue mutated as compared to a wild-type histidine decarboxylase, and having higher histidine decarboxylase activity and/or stability than the wild-type histidine decarboxylase, and also a use thereof. The mutated histidine decarboxylase has Motifs (1) to (6), and an amino acid residue in at least one motif thereof can be mutated. The mutated histidine decarboxylase can also have a mutation of at least one amino acid residue in an amino acid sequence designated by SEQ ID NO: 3 and in a homologous sequence thereto.Type: GrantFiled: February 6, 2023Date of Patent: November 19, 2024Assignee: AJINOMOTO CO., INC.Inventors: Hiroki Yamaguchi, Masayuki Sugiki, Kunio Nakata
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Patent number: 12139720Abstract: This invention relates to recombinant lentiviral vectors, compositions thereof, the use of the vectors or the compositions thereof, kits of parts comprising said vectors or compositions thereof and a catalytically active Cas9 or Cpf1 protein, methods for modifying the genome of a hematopoietic stem/progenitor cell (HSPC), and the HSPC obtainable by such methods.Type: GrantFiled: June 1, 2018Date of Patent: November 12, 2024Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, IMAGINE—INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADESInventors: Annarita Miccio, Vasco Meneghini
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Patent number: 12133495Abstract: Methods and compositions useful for avoiding plant meiosis and clonal reproduction through seed are provided herein. The present disclosure provides polynucleotides and related polypeptides of Spo11, Rec8, OSD1-1A, and OSD1-3A and methods and compositions for suppressing their expression level or activity.Type: GrantFiled: March 17, 2017Date of Patent: November 5, 2024Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Marc C Albertsen, Tim Wayne Fox, Marissa Simon, Mark E Williams
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Patent number: 12134768Abstract: There are disclosed functional nucleic acid molecules comprising a target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced; and a regulatory sequence having two-dimensional structures comprising specific stem-loop and internal loop domains and displaying translation enhancing efficiency.Type: GrantFiled: February 5, 2019Date of Patent: November 5, 2024Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIAInventors: Stefano Gustincich, Silvia Zucchelli, Peter Podbevsek, Janez Plavec, Piero Carninci, Hazuki Takahashi, Toshio Yamazaki, Takako Ohyama, Harshita Sharma
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Patent number: 12123034Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject.Type: GrantFiled: August 10, 2023Date of Patent: October 22, 2024Assignee: Flagship Pioneering Innovations VI, LLCInventors: Robert Charles Altshuler, Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, Randi Michelle Kotlar, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg
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Patent number: 12121593Abstract: The application provides gene therapies for treating monogenic forms of nephrotic syndrome.Type: GrantFiled: June 15, 2021Date of Patent: October 22, 2024Assignee: The University of BristolInventors: Moin Ahson Saleem-Uddin, Gavin Iain Welsh, Wen Yi Ding
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Patent number: RE50283Abstract: The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.Type: GrantFiled: December 3, 2021Date of Patent: January 28, 2025Assignee: FONDAZIONE TELETHON ETSInventors: Alberto Auricchio, Pasqualina Colella, Ivana Trapani