Plant Cell Or Cell Line, Per Se, Contains Exogenous Or Foreign Nucleic Acid Patents (Class 435/419)
  • Plants having altered growth and/or development resulted from modulated expression of ubiquitin-specific proteases and a method for making the same
    Patent number: 9029638
    Abstract: The present invention relates generally to the field of molecular biology and concerns a method for altering various aspects of plant growth and/or development by modulating expression in a plant of a nucleic acid encoding an UBiquitin-Specific Protease (UBP) of the UBP15 subfamily or a homologue thereof. The present invention also concerns plants having modulated expression of a nucleic acid encoding a UBP15 or a homologue thereof, which plants have altered growth and/or development relative to corresponding wild type plants or other control plants. The invention also provides constructs useful in the methods of the invention.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: May 12, 2015
    Assignee: National Institute for Biological Sciences
    Inventors: Xing Wang Deng, Yanfen Liu
  • NOVEL ANTI-SIGLEC-15 ANTIBODY
    Publication number: 20150125470
    Abstract: Provided is a pharmaceutical composition for the treatment and/or prophylaxis of abnormal bone metabolism targeting a protein encoded by a gene strongly expressed in osteoclasts. Specifically provided is a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation, and the like.
    Type: Application
    Filed: March 29, 2013
    Publication date: May 7, 2015
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Yoshiharu Hiruma, Jun Hasegawa
  • ANTI-FGFR2 ANTIBODY
    Publication number: 20150125454
    Abstract: The present invention provides an antibody which binds to a fibroblast growth factor receptor.
    Type: Application
    Filed: April 9, 2013
    Publication date: May 7, 2015
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Toshiaki Ohtsuka, Chigusa Yoshimura, Toshinori Agatsuma, Atsushi Urano, Takako Kimura, Yumi Matsui, Tatsuji Matsuoka, Jun Hasegawa, Yasuki Kamai, Reimi Kawaida
  • Anti-CCL17 Antibodies
    Publication number: 20150125458
    Abstract: The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Inventors: Ken Boakye, Alfred Del Vecchio, John Kehoe, Eilyn Lacy, Lynne Murray, Mary Ryan, Sandra Santulli-Marotto, John Wheeler, Brian Whitaker, Alexey Teplyakov
  • POLYNUCLEOTIDE ENCODING CaTLP1 PROTEIN AND USES THEREOF
    Publication number: 20150128305
    Abstract: The present invention provides herein a polynucleotide sequence encoding the tubby-like protein, CaTLP1, from chickpea (Cicer arientium L.) that is responsive to abiotic stress and is involved in plant growth and development. Further, the recombinant DNA construct and recombinant vector comprising the polynucleotide sequence encoding CaTLP1, host cell comprising the recombinant vector and a process for producing a transgenic plant that expresses the CaTLP1 protein are also provided herein.
    Type: Application
    Filed: May 7, 2013
    Publication date: May 7, 2015
    Inventors: Niranjan Chakraborty, Subhra Chakraborty, Asis Datta, Vijay Wardhan, Kishwer Jahan
  • Method and Pharmaceutical Composition for use in the Treatment of Cancer
    Publication number: 20150126456
    Abstract: The present invention relates to a soluble peptide comprising the amino acids sequence: KRFYVVMWKK (SEQ ID NO: 1) or a function-conservative variant thereof for use in the treatment of cancer. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: June 6, 2013
    Publication date: May 7, 2015
    Inventors: Santos Susin, Pierre Launay, Philippe Karoyan, Helene Merle-Beral
  • Eukaryotic Expression System And Use Thereof
    Publication number: 20150125849
    Abstract: Provided are a eukaryotic expression system and its applications. The eukaryotic expression system has a recombinant plant cell. The recombinant plant cell includes a first vector and a second vector. The first vector expresses a fusion protein containing an Asia tospoviral common epitope. The fusion protein containing Asia tospoviral common epitope consists of an amino acid sequence as set forth in SEQ ID NO. 1, and a predetermined protein fragment connecting to the Asia tospoviral common epitope. The above eukaryotic expression system is useful for monitoring the interaction between proteins via use of a specific peptide to tag the predetermined protein and demonstrates high sensitivity and stability.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 7, 2015
    Applicant: National Chung Hsing University
    Inventors: Shyi-Dong Yeh, Hao-Wen Cheng
  • DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IMMUNE CELL RECEPTORS AND AUTOANTIGENS
    Publication number: 20150125397
    Abstract: Engineered multivalent and multispecific binding proteins that bind immune cell receptors and/or autoantigens are provided, along with methods of making and uses in the prevention, diagnosis, prognosis and/or treatment of disease.
    Type: Application
    Filed: October 6, 2014
    Publication date: May 7, 2015
    Inventors: Chee-Ho Choi, Tariq Ghayur, Ann Marshak-Rothstein, Krishna Moody
  • TRAIL COLLECTIN FUSION PROTEINS
    Publication number: 20150126709
    Abstract: The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin trimerization domain, to a nucleic acid molecule encoding the fusion protein, and to a cell comprising the nucleic acid molecule. The fusion protein is present as a trimeric complex or as an oligomer thereof. The fusion protein, the nucleic acid, and the cell is suitable as pharmaceutical composition or for therapeutic, diagnostic and/or research applications.
    Type: Application
    Filed: July 2, 2014
    Publication date: May 7, 2015
    Inventors: Oliver HILL, Christian Gieffers, Meinolf Thiemann, Marcus Branschädel
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20150126445
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Application
    Filed: December 10, 2014
    Publication date: May 7, 2015
    Inventors: FUAD FARES, UDI EYAL FIMA
  • AROMATIC PRENYLTRANSFERASE FROM CANNABIS
    Publication number: 20150128301
    Abstract: Nucleic acid molecules from cannabis has been isolated and characterized and encode polypeptides having aromatic prenyltransferase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Application
    Filed: October 9, 2014
    Publication date: May 7, 2015
    Inventors: Jonathan E. Page, Zakia Boubakir
  • COLON DISEASE TARGETS AND USES THEREOF
    Publication number: 20150125456
    Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.
    Type: Application
    Filed: October 22, 2014
    Publication date: May 7, 2015
    Applicant: CELERA CORPORATION
    Inventors: Yeounjin KIM, Tao HE, Steve RUBEN
  • Maize ERECTA genes for improving plant growth, transpiration, efficiency and drought tolerance in crop plants
    Patent number: 9024141
    Abstract: The present invention provides polynucleotides and related polypeptides of the ZmERECTA gene family. The invention provides nucleic acid sequences for the Zm ERECTA genes. ZmERECTA is responsible for controlling plant growth, organ size and yield in crop plants.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: May 5, 2015
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Mei Guo, Mary Rupe, Carl Simmons, Shoba Sivasankar
  • METHODS FOR THE PRODUCTION OF CYTOPROTECTIVE ASIALO-ERYTHROPOIETIN IN PLANTS AND ITS PURIFICATION FROM PLANT TISSUES
    Publication number: 20150119325
    Abstract: The present invention provides methods for the high-level production of recombinant human erythropoietin (rhuEPO) derivative, asialoerythropoietin (asialo-rhuEPO), in plants. The methods for producing asialo-rhuEPO comprise making a plant or at least one plant cell that comprises a promoter that drives expression in a plant cell operably linked to a polynucleotide encoding a human erythropoieting fusion protein and a promoter that drives expression in a plant cell operably linked to a polynucleotide encoding N-glycosylation modification enzyme, particularly a mammalian ?1,4-galactosyltransferase. The present invention further provides plants, plant cells, and seeds that have been genetically modified to produce high levels of asialo-rhuEPO. Additionally, provided are methods for purifying asialo-rhuEPO from plant tissues.
    Type: Application
    Filed: March 14, 2013
    Publication date: April 30, 2015
    Applicant: NORTH CAROLINA CENTRAL UNIVERSITY
    Inventors: Jiahua Xie, Farooqahmed S. Kittur, Chiu-Yueh Hung
  • ANTI-LAMP5 ANTIBODY AND UTILIZATION THEREOF
    Publication number: 20150118184
    Abstract: A monoclonal antibody recognizing the extracellular region of LAMP5 was produced. The produced antibody demonstrated antibody-dependent cell-mediated cytotoxic activity, and/or cell growth inhibitory activity in the presence of a toxin-labeled secondary antibody, against a multiple myeloma cell line.
    Type: Application
    Filed: March 29, 2013
    Publication date: April 30, 2015
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventor: Shigeto Kawai
  • ISOLATED POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, TRANSGENIC PLANTS EXPRESSING SAME AND METHODS OF USING SAME
    Publication number: 20150121573
    Abstract: Nucleic acid constructs are provided. These constructs comprise any of the, nucleic acid sequences at least 85% identical to nucleotide sequences selected from the group consisting of SEQ ID NOs: 68, 1, 4, 5, 8, 9, 11, 13, 16, 19, 20, 23, 24, 27, 30, 32, 37, 42, 49, 50, 51, 53, 54, 55, 56, 57, 58, 64, 69, 70, 73, 77, 78, 79, 80, 84, 86, 87, 93, 94, 98, 101, 102, 103, 104, 105, 106, 107, 108 and 109 and a promoter sequence capable of directing transcription of said nucleic acid sequence in a host cell. Also provided are transgenic plants expressing these nucleic acid constructs and methods of using same.
    Type: Application
    Filed: January 5, 2015
    Publication date: April 30, 2015
    Applicant: EVOGENE LTD.
    Inventors: Rodrigo YELIN, Avi SHOSHAN, Evgenia GOLD, Sharon AYAL, Hagai KARCHI
  • GENE IMPLICATED IN DROUGHT STRESS TOLERANCE AND TRANSFORMED PLANTS WITH THE SAME
    Publication number: 20150121570
    Abstract: The present invention relates to a composition for improving a tolerance to drought and oxidative stress of a plant, a plant transformed with the composition, a method for preparing a plant transformed with the composition, a method for improving a tolerance to a drought and oxidative stress and a composition and method for a germination rate of a plant. The nucleotide sequences of the present invention are involved in the drought and oxidative stress-tolerance and germination capacity, therefore may be effectively used for cultivating the plants with enhanced tolerance against abiotic stress or novel function of rapid growing or bolting.
    Type: Application
    Filed: April 22, 2014
    Publication date: April 30, 2015
    Applicant: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Woo Taek KIM, Eun Yu KIM, Moon Yong RYU, Yoon A CHOI
  • CELERY CULTIVAR ADS-26
    Publication number: 20150121558
    Abstract: A celery cultivar, designated ADS-26, is disclosed. The invention relates to the seeds of celery cultivar ADS-26, to the plants of celery cultivar ADS-26 and to methods for producing a celery plant by crossing the cultivar ADS-26 with itself or another celery cultivar. The invention further relates to methods for producing a celery plant containing in its genetic material one or more transgenes and to the transgenic celery plants and plant parts produced by those methods. This invention also relates to celery cultivars or breeding cultivars and plant parts derived from celery cultivar ADS-26, to methods for producing other celery cultivars, lines or plant parts derived from celery cultivar ADS-26 and to the celery plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid celery seeds, plants, and plant parts produced by crossing cultivar ADS-26 with another celery cultivar.
    Type: Application
    Filed: October 24, 2013
    Publication date: April 30, 2015
    Applicant: A. DUDA & SONS, INC.
    Inventor: LAWRENCE K. PIERCE
  • CELERY CULTIVAR ADS-25
    Publication number: 20150121557
    Abstract: A celery cultivar, designated ADS-25, is disclosed. The invention relates to the seeds of celery cultivar ADS-25, to the plants of celery cultivar ADS-25 and to methods for producing a celery plant by crossing the cultivar ADS-25 with itself or another celery cultivar. The invention further relates to methods for producing a celery plant containing in its genetic material one or more transgenes and to the transgenic celery plants and plant parts produced by those methods. This invention also relates to celery cultivars or breeding cultivars and plant parts derived from celery cultivar ADS-25, to methods for producing other celery cultivars, lines or plant parts derived from celery cultivar ADS-25 and to the celery plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid celery seeds, plants, and plant parts produced by crossing cultivar ADS-25 with another celery cultivar.
    Type: Application
    Filed: October 24, 2013
    Publication date: April 30, 2015
    Applicant: A. DUDA & SONS, INC.
    Inventor: LAWRENCE K. PIERCE
  • METHOD OF HIGH-THROUGHPUT SORTING OF HIGH EXPRESSION CELL AND CELLS SORTED THEREFROM
    Publication number: 20150118693
    Abstract: The invention provides a method of high-throughput sorting of high expression protein-producing cell, which utilizes linking a protein and a transmembrane domain with a self-processing cleavage site and regulating the secretion of the protein or expression of protein on the cell membrane by adding self-processing cleavage enzyme inhibitor. Then, the high expression cell line can be high-throughput sorted by a detection technique. The invention also provides a recombinant nucleotide sequence and a vector used in the method and a cell sorted by the method.
    Type: Application
    Filed: April 28, 2014
    Publication date: April 30, 2015
    Applicant: Taipei Medical University
    Inventors: KUO-HSIANG CHUANG, TIAN-LU CHENG, I-SHIUAN CHIANG, YUAN-CHIN HSIEH
  • OVULE SPECIFIC PROMOTER AND METHODS OF USE
    Publication number: 20150121568
    Abstract: Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences for an Arabidopsis thaliana (AT SVL3) promoter. Also provided is a method for expressing a heterologous nucleotide sequence in a plant using a promoter sequence disclosed herein.
    Type: Application
    Filed: January 15, 2015
    Publication date: April 30, 2015
    Inventors: Mark Alan Chamberlin, Shai Joshua Lawitt
  • METHOD FOR THE ENZYMATIC PRODUCTION OF ISOPRENOL USING MEVALONATE AS A SUBSTRATE
    Publication number: 20150118725
    Abstract: Described is a method for generating isoprenol through a biological process. More specifically, described is a method for producing isoprenol from mevalonate.
    Type: Application
    Filed: April 4, 2013
    Publication date: April 30, 2015
    Inventors: Marc Delcourt, Maria Anissimova, Philippe Marliere
  • GENES RELATED TO SALT OR DROUGHT STRESS RESISTANCES AND TRANSFORMED PLANTS WITH THE SAME
    Publication number: 20150121571
    Abstract: The present invention relates to a composition for improving a tolerance to a salt stress or a drought stress of a plant, and a method for preparing transformed plant exhibiting improved tolerance to salt stress or drought stress. The nucleotide sequences of the present invention are involved in salt or drought stress-tolerance, therefore may be effectively used for cultivating the plants with novel functional features which are less affected by climates and environments of the cultivated areas.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 30, 2015
    Inventors: Woo Taek KIM, Jae Hwan HWANG, Dong Hye SEO
  • Genes that increase plant oil and method for using the same
    Patent number: 9018446
    Abstract: This invention is intended to be used to search for a transcription factor having novel functions of increasing the weight of an individual plant, increasing the weight of a given tissue per individual plant, or improving the productivity of a given substance per individual plant and to improve such properties in the plant. The weight of an individual plant is increased, the weight of a given tissue per individual plant is increased, the productivity of a given substance per individual plant is improved, or the content of a given substance per given tissue of a plant is increased via expression of a transcription factor that has been modified to suppress transcription accelerating activity.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: April 28, 2015
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Hiroshi Chatani, Chikara Ohto, Yukio Okamura, Norihiro Mitsukawa, Nobuhiko Muramoto, Tomotsugu Koyama, Kyoko Matsui, Masaru Takagi
  • Use of CAD genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant
    Patent number: 9018445
    Abstract: Provided are methods of increasing nitrogen use efficiency, fertilizer use efficiency, yield, growth rate, vigor, biomass, oil content and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80% identical to SEQ ID NO: 2506, 2512, 2442, 2496, 2446, 1, 2, 4, 7, 8, 11, 12, 13, 16-19, 21-60, 63-128, 130-137, 270-287, 289-293, 295-306, 308-362, 364-666, 671, 673-1333, 2414-2441, 2443-2445, 2447-2455, 2458-2495, 2497-2505, 2507-2511, 2513-2521 or 2522; and of increasing nitrogen use efficiency, fertilizer use efficiency and/or oil content of a plant by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80% identical to SEQ ID NO: 3, 5, 6, 9, 10, 14, 15, 288, 294, 2398-2412 or 2413.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: April 28, 2015
    Assignee: Evogene Ltd.
    Inventors: Basia J. Vinocur, Sharon Ayal, Alex Diber, Eyal Emmanuel, Gil Ronen, Michael Gang, Dotan Dimet, Hagai Karchi, Yoav Herschkovitz
  • Tomato line CHI 12-94083
    Patent number: 9018474
    Abstract: The invention provides seed and plants of tomato line CHI 12-94083. The invention thus relates to the plants, seeds and tissue cultures of tomato line CHI 12-94083, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: April 28, 2015
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventor: Antonius Cornelis Maria van de Ven
  • Polypeptides Having Alpha-Glucuronidase Activity And Polynucleotides Encoding Same
    Publication number: 20150110765
    Abstract: The present invention relates to isolated polypeptides having alpha-glucuronidase activity, catalytic domains and polynucleotides encoding the polypeptides, catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides or catalytic domains.
    Type: Application
    Filed: April 22, 2013
    Publication date: April 23, 2015
    Inventors: Johan Börjesson, Anders Vikø-Nielsen, Nikolaj Spodsberg, Kristian Krogh
  • GRAPEVINE PLANT NAMED JB05-22-3-27
    Publication number: 20150113678
    Abstract: A grapevine cultivar designated JB05-22-3-27 is disclosed. The invention relates to the plants of grapevine cultivar JB05-22-3-27, to the plant parts of grapevine cultivar JB05-22-3-27 and to methods for producing a grapevine plant produced by crossing grapevine cultivar JB05-22-3-27 with itself or with another grapevine variety. The invention also relates to methods for producing a grapevine plant containing in its genetic material one or more transgenes and to the transgenic grapevine plants and plant parts produced by those methods. This invention also relates to grapevine cultivars or breeding cultivars and plant parts derived from grapevine variety JB05-22-3-27, to methods for producing other grapevine cultivars, lines or plant parts derived from grapevine cultivar JB05-22-3-27 and to the grapevine plants, varieties, and their parts derived from use of those methods.
    Type: Application
    Filed: October 23, 2013
    Publication date: April 23, 2015
    Applicant: SCARLET TANAGER
    Inventor: Patterson Jeffrey Bloodworth
  • DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING
    Publication number: 20150110762
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 23, 2015
    Inventors: Michael C. Holmes, Jianbin Wang
  • Transgenic plants with enhanced agronomic traits
    Publication number: 20150113676
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: September 24, 2014
    Publication date: April 23, 2015
    Inventors: Mark Scott Abad, Thomas R. Adams, Julie A. Alvarez, Mahindra Anuradha, Alice Clara Augustine, Erin Bell, Kristen A. Bennett, Robert J. Bensen, Paolo Castiglioni, Richard E. Cerny, Xianfeng Chen, Jaishree M. Chittoor-Vijayanath, Farah Deeba, Jill Deikman, Molian Deng, Meghan Galligan-Donnarummo, Stephen Duff, Bradon J. Fabbri, Jason Fenner, Mary Fernandes, Karen Gabbert, Barry S. Goldman, Deborah J. Hawkins, Jacqueline E. Heard, Balasulojini Karunanandaa, Dangyang Ke, John R. Ledeaux, Garrett J. Lee, Savitha Madappa, Donald E. Nelson, Obed Patty, Badami S. Pranesh, Qungang Qi, Ramachandra Dhanalakshmi, G. Ramamohan, Thomas G. Ruff, Rick A. Sanders, Sangeetha Singh, Thomas J. Savage, Beth Savidge, Char Shobha, Rajani Monnanda Somaiah, Padmini Sudarshana, Sreekanta Navarathna Suma, Jindong Sun, Rebecca L. Thompson-Mize, Dale L. Val, Srikanth Venkatachalayya, Tymagondlu V. Venkatesh, Kammaradi Vidya, Jingrui Wu, Zhidong Xie, Nanfei Xu, Wei Zheng, Rajani Monnanda Somaiah
  • HSF-LIKE TRANSCRIPTION FACTOR, TBF1, IS A MAJOR MOLECULAR SWITCH FOR GROWTH-TO-DEFENSE TRANSITION IN PLANTS
    Publication number: 20150113685
    Abstract: The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from regions comprising binding sites for transcription factors, such as the cis-element translocon 1 (TL1) comprising GAAGAAGAA and similar sequences. The invention relates to isolated nucleotide sequences comprising a regulatory region comprising a promoter operably-linked to one or more upstream open reading frames (uORFs) and one or more downstream open reading frames (dORFs) encoding one or more functional polypeptides, including transcription factors such as TBF1, reporter polypeptides, and polypeptides conferring resistance to drugs, resistance of plants viral, bacterial, or fungal pathogens, and polypeptides involved in the growth of plants.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 23, 2015
    Inventors: Karolina M. PAJEROWSKA-MUKHTAR, Guoyong XU, Xinnian DONG
  • TNF-ALPHA BINDING PROTEINS
    Publication number: 20150111251
    Abstract: TNF-? binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-? are provided. Binding proteins have high affinity for TNF-? and neutralize TNF-? activity. A binding protein can be a full-length antibody or a TNF-?-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-? binding proteins are useful for detecting TNF-? and for inhibiting TNF-? activity, including in a human subject suffering from a disease or disorder in which TNF-? activity is detrimental.
    Type: Application
    Filed: September 25, 2014
    Publication date: April 23, 2015
    Inventors: Chung-ming HSIEH, Carrie GOODREAU, Tariq GHAYUR, Achim MOELLER, Sahana BOSE
  • ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
    Publication number: 20150110791
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Application
    Filed: May 20, 2014
    Publication date: April 23, 2015
    Applicant: GENENTECH, INC.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S. Dennis, James A. Ernst, Ryan J. Watts, Gregory A. Lazar
  • EPITOPE FOCUSING BY VARIABLE EFFECTIVE ANTIGEN SURFACE CONCENTRATION
    Publication number: 20150110836
    Abstract: The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope focusing by variable effective antigen surface concentration. Generally, the composition and methods of the disclosure comprise three steps: a “design process” comprising one or more in silico bioinformatics steps to select and generate a library of potential antigens for use in the immunogenic composition; a “formulation process”, comprising in vitro testing of potential antigens, using various biochemical assays, and further combining two or more antigens to generate one or more immunogenic compositions; and an “administering” step, whereby the immunogenic composition is administered to a host animal, immune cell, subject or patient. Further steps may also be included, such as the isolation and production of antibodies raised by host immune response to the immunogenic composition.
    Type: Application
    Filed: May 21, 2013
    Publication date: April 23, 2015
    Inventor: Jacob E. Glanville
  • GENETICALLY ENCODED BIOSENSORS
    Publication number: 20150111222
    Abstract: The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte.
    Type: Application
    Filed: August 8, 2012
    Publication date: April 23, 2015
    Applicant: HOWARD hUGHES MEDICAL INSTITUTE
    Inventors: Jonathan Marvin, Loren Looger, Richard T. Lee, Eric Schreiter
  • Nucleic Acid for Determining Actin Structures in Living Cells
    Publication number: 20150113671
    Abstract: The present invention relates to nucleic acids encoding peptides capable of binding to actin. The nucleic acids encoding the peptides are useful in methods for detecting actin in vitro or in living cells.
    Type: Application
    Filed: January 9, 2015
    Publication date: April 23, 2015
    Inventors: Roland Wedlich-Soldner, Michael Sixt, Julia Riedl, Alvaro Crevenna
  • GLUCAGON ANALOGUES
    Publication number: 20150111817
    Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 23, 2015
    Inventors: Ditte RIBER, Jakob Lind TOLBORG, Dieter Wolfgang HAMPRECHT
  • ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM CORN AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS
    Publication number: 20150113680
    Abstract: This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 23, 2015
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventors: David K. KOVALIC, Jack E. TABASKA, Bo-Xing QIU, Wei WU
  • Isolated novel acid and protein molecules from soy and methods of using those molecules to generate transgene plants with enhanced agronomic traits
    Patent number: 9012723
    Abstract: This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: April 21, 2015
    Assignee: Monsanto Technology LLC
    Inventors: Liang Guo, David K. Kovalic, Bo-Xing Qiu, Jack E. Tabaska, Wei Wu
  • Compositions and methods for modifying gene expression using the promoter of ubiquitin conjugating protein coding gene of soybean plants
    Patent number: 9012720
    Abstract: A polynucleotide isolated from soybean plants capable of initiating transcription and with sequence identity to SEQ ID No. 1 is provided. In some aspects, the polynucleotide has sequence identity to SEQ ID No. 1 of at least 40%, is the reverse complement or the reverse of such sequences. In some aspects, the polynucleotide is linked to expression enhancers or sequences of interest. In some embodiments, a recombinant vector comprises the polynucleotide. In some aspects, the recombinant vector comprises enhancers, termination sequences, or sequences of interest. In some embodiments a transformed cell, plant, plant part, or propagulum comprise the polynucleotide.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: April 21, 2015
    Assignee: Empresa Brasileira de Pesquisa Agropecuaria
    Inventors: Maria Fatima Grossi de Sa, Luciane Mourao Guimaraes, Joao Aguiar Nogueira Batista, Antonio Americo Barbosa Viana, Rodrigo da Rocha Fragoso, Maria Cristina Mattar da Silva
  • Polynucleotides and polypeptides involved in plant fiber development and methods of using same
    Patent number: 9012728
    Abstract: Isolated polynucleotides are provided. Each of the isolated polynucleotides comprise a nucleic acid sequence encoding a polypeptide having an amino acid sequence at least 80% homologous to SEQ ID NO: 121, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 122, 123, 124, 125, 126, 95 or 96, wherein the polypeptide is capable of regulating cotton fiber development. Also provided are methods of using such polynucleotides for improving fiber quality and/or yield of a fiber producing plant, as well as methods of using such polynucleotides for producing plants having increased biomass/vigor/yield.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: April 21, 2015
    Assignee: Evogene Ltd.
    Inventors: Gil Ronen, Evgenia Gold, Rodrigo Yelin, Rafael Meissner, Hagai Karchi, Sharon Ayal
  • Transgenic plants with improved growth and nitrogen use efficiency
    Patent number: 9012721
    Abstract: The invention relates to transgenic plants with improved growth and nitrogen use efficiency expressing nitrate transporter gene, methods of making such plants and methods for improving growth and nitrogen use efficiency.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: April 21, 2015
    Assignees: Plant Bioscience Limited, Nanjing Agricultural University
    Inventors: Guohua Xu, Xiaorong Fan, Qirong Shen, Anthony Miller
  • HOUSE DUST MITE ALLERGEN
    Publication number: 20150104458
    Abstract: A polypeptide containing an amino acid sequence having at least 60% identity to the amino acid sequence SEQ ID No. 1 or containing at least one amino acid fragment of at least 6 consecutive amino acid residues of the amino acid sequence SEQ ID No. 1 or having immunological cross-reactivity to the amino acid sequence SEQ ID No. 1 or fragments thereof, wherein the amino acid sequence SEQ ID No. 1 codes for an allergen and the polypeptide comprises at least one T cell epitope recognized by a T cell receptor specific for a molecule having the amino acid sequence SEQ ID No. 1.
    Type: Application
    Filed: August 26, 2014
    Publication date: April 16, 2015
    Applicant: Biomay AG
    Inventors: Rudolf VALENTA, Margit Weghofer, Susanne Vrtala, Friedrich Horak, Peter Valent, Stefan Florian
  • Polypeptide Fragments Comprising Endonuclease Activity and Their Use
    Publication number: 20150105315
    Abstract: The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyxoviridae family. This invention also relates to (i) crystals of the polypeptide fragments which are suitable for structure determination of said polypeptide fragments using X-ray crystallography and (ii) computational methods using the structural coordinates of said polypeptide to screen for and design compounds that modulate, preferably inhibit the endonucleolytically active site within the polypeptide fragment. In addition, this invention relates to methods identifying compounds that bind to the PA polypeptide fragments possessing endonuclease activity and preferably inhibit said endonucleolytic activity, preferably in a high throughput setting.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 16, 2015
    Applicants: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), UNIVERSITY JOSEPH FOURIER FILIALE, Centre National de la Recherche Scientifique - Direction de la Politique Industrielle
    Inventors: Denis Bouvier, Thibaut Crepin, Rob Ruigrok, Alexander Dias, Stephen Cusack
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20150104452
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: June 10, 2014
    Publication date: April 16, 2015
    Inventors: Tariq Ghayur, Edward B. Reilly, Andrew Phillips, Randy L. Bell, Yingchun Li, Hua Ying, Susan E. Morgan-Lappe, Gillian A. Kingsbury, Jieyi Wang, Suzanne M. Norvell, Junjian Liu
  • WOODY PLANTS HAVING IMPROVED GROWTH CHARACTERISTICS AND METHOD FOR MAKING THE SAME USING TRANSCRIPTION FACTORS
    Publication number: 20150106967
    Abstract: An extensive analytical platform for selecting genes with a possible commercial phenotype from a large group of candidate genes identified using tools in bioinformatics, data from EST sequencing and DNA array is disclosed. Methods are disclosed for producing a transgenic plant having an increased growth compared to its wild type by altering in the plant the level of a gene product of at least one gene specifically expressed during different phases of wood formation. This may be done with transgenic methods or by specific crossing methods. Plant cells or plant progeny and wood having modulated gene expression are also disclosed. A DNA construct with a nucleotide sequence for a gene producing a transgenic plant having an increased growth compared to its wild type and a plant cell or plant progeny having the DNA construct are also disclosed.
    Type: Application
    Filed: December 4, 2014
    Publication date: April 16, 2015
    Inventors: Magnus Hertzberg, Rishikesh Bhalerao, David Jonsén, Linus Möller, Pär Jonsson
  • THREONINE SYNTHASE FROM NICOTIANA TABACUM AND METHODS AND USES THEREOF
    Publication number: 20150106971
    Abstract: There is disclosed a mutant, non-naturally occurring or transgenic plant cell comprising: (i) a polynucleotide comprising, consisting or consisting essentially of a sequence encoding a threonine synthase and having at least 90% sequence identity to SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3 or at least 87% sequence identity to SEQ ID NO:4, or SEQ ID NO:5; (ii) a polypeptide encoded by any one of said polynucleotides set forth in (i); or (iii) a polypeptide having at least 95% sequence identity to SEQ ID NO:6, SEQ ID NO:7 or SEQ ID NO:8; or (iv) a construct, vector or expression vector comprising the polynucleotide as set forth in (i).
    Type: Application
    Filed: August 31, 2012
    Publication date: April 16, 2015
    Applicant: PHILIP MORRIS PRODUCTS S.A.
    Inventors: Lucien Bovet, Nicolas Sierro
  • PLANT DEFENSE GENES AND PROTEINS AND METHODS OF USE
    Publication number: 20150106972
    Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding plant defense proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Applicant: PIONEER HI BRED INTERNATIONAL INC
    Inventors: James Joseph English, Carl Robert Simmons, Nasser Yalpani
  • PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME
    Publication number: 20150106974
    Abstract: The present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of one ore more nucleic acid(s) encoding at least two iSYT (interactor of SYT—synovial sarcoma translocation—) polypeptides. The present invention also concerns plants having modulated expression of a nucleic acid encoding at least two iSYT polypeptides, which plants have enhanced yield-related traits relative to corresponding wild type plants or other control plants. Nucleic acids encoding at least two iSYT polypeptides and constructs comprising the same useful in performing the methods of the invention are also disclosed. Also provided are constructs useful in the methods of the invention. The present invention also relates to an iSYT-based protein complex. The use of the complex to promote plant growth, and a method for stimulating the complex formation, by overexpressing at least two members of the complex, are also disclosed.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 16, 2015
    Inventors: VALERIE FRANKARD, ANDRY ANDRIANKAJA, YVES HATZFELD, MARIEKE LOUWERS, STEVEN VANDENABEELE, AURINE VERKEST, GEERT DE JAEGER, DIRK INZÉ
  • IL-17 ANTAGONIST ANTIBODIES
    Publication number: 20150104457
    Abstract: The disclosure relates to antibodies against human IL-17 which act as antagonist antagonists of IL-17, and their use in the diagnosis or treatment of IL-17 mediated diseases.
    Type: Application
    Filed: June 25, 2013
    Publication date: April 16, 2015
    Inventors: Gilles Alberici, Jeremy Bastid, Armand Bensussan, Nathalie Bonnefoy, Jean-Francois Eliaou