Mutation Employing A Chemical Mutagenic Agent Patents (Class 435/441)
  • Patent number: 12245562
    Abstract: The present invention provides a longitudinally split immature tiller separated from a rhizome (LSITR), a cluster of multiple in vitro shoots (CMIT), a cluster of stem segments containing shoot primordia (CSSSP) and an in vitro tiller of Miscanthus x giganteus (Giant miscanthus), and their uses in propagating Miscanthus x giganteus (Giant miscanthus).
    Type: Grant
    Filed: February 21, 2023
    Date of Patent: March 11, 2025
    Assignee: Delaware State University
    Inventors: Bertrand B. Hankoua, Ayalew Ligaba Osena
  • Patent number: 12227771
    Abstract: Expression systems for the expression of an ?9?10 nicotinic acetylcholine receptor (nAChR) are described. Also described are methods of using the expression systems to identify agonists, antagonists, or allosteric modulators of an ?9?10 nAChR.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: February 18, 2025
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: David S. Bredt, Weston Davini, Shenyan Gu, Jose Matta, Min Lei O'Carroll
  • Patent number: 12215320
    Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., Hemophilia A, employing ex vivo and/or in vivo genome editing.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: February 4, 2025
    Assignees: CRISPR Therapeutics AG, BAYER HEALTHCARE LLC
    Inventors: Alan Richard Brooks, Karen Vo
  • Patent number: 12209247
    Abstract: The present invention relates to methods and compositions for targeted insertion of polynucleotide molecules into ideal target sites in the genome of a maize plant. The present invention relates to maize recombinant molecules comprising heterologous sequences and also to methods of integrating a DNA of interest into a target maize genomic locus in a maize genome. The present invention also relates to regenerated maize plants or plant parts comprising the recombinant molecules and/or a DNA of interest.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: January 28, 2025
    Assignee: Syngenta Crop Protection AG
    Inventors: Yinping Lucy Qin, Mark Rose, Zhongying Chen, Heng Zhong, Weining Gu, Wenling Wang, Qiudeng Que, Ailing Zhou, Mary-Dell Chilton
  • Patent number: 11939577
    Abstract: The present invention relates to antisense RNAs targeting PMP22 and able to inhibit from 40% to 60% the expression of PMP22 in the cells and a pharmaceutical composition comprising thereof. The antisense RNAs are preferably siRNA and are preferably provided in the form of nanoparticles. The present invention also relates to the use of these antisense RNAs targeting PMP22 for the treatment of Charcot-Marie-Tooth 1A disease.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: March 26, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Liliane Massade, Charbel Massaad, Susan Boutary, Giorgia Maria Laura Urbinati, Patrick Couvreur, Didier Desmaƫle
  • Patent number: 11639510
    Abstract: Devices and methods are presented for delivery of various macrostructures into cells, such as depleted cells as well as methods of generating engineered cells using said devices and methods. Cells are placed on a porous membrane. A force is applied by a configurable actuator to a deformable fluid reservoir that generates an applied pressure to macrostructures in a solution, causing the macrostructures to pass through the porous membrane and triggering uptake of at least some of the macrostructures into the cells to form transfected cells. Said devices and methods may be used in a process to replace defective endogenous mtDNA with corrected mtDNA to generate cellular-based therapeutics for administration to a patient. The customizable actuator may be configured with parameters to optimize efficiency for a given cell type and material to be transfected. Machine learning techniques also may be utilized to optimize transfection parameters.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: May 2, 2023
    Assignee: NANOCAV, LLC
    Inventors: Ting-Hsiang Sherry Wu, Artin Mehrabi, Jon Thomas Van Lew
  • Patent number: 11352437
    Abstract: The present description relates to a conjugated compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to a compound of interest.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: June 7, 2022
    Assignee: DEFENCE THERAPEUTICS INC.
    Inventors: Simon Beaudoin, Jeffrey Victor Leyton
  • Patent number: 11248232
    Abstract: A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 15, 2022
    Assignees: KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO, THE UNIVERSITY OF TOKYO, MEIJI UNIVERSITY
    Inventors: Hidenori Tanaka, Nobuhiko Muramoto, Hiroki Sugimoto, Norihiro Mitsukawa, Chikara Ohto, Satoshi Kondo, Kunihiro Ohta, Takahiro Nakamura, Shuichi Osato
  • Patent number: 11104897
    Abstract: The present invention relates to compositions and methods for the treatment of nucleotide repeat expansion disorders such as myotonic dystrophy.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: August 31, 2021
    Assignees: GENETHON, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'EVRY VAL D'ESSONNE
    Inventors: Ana Maria Buj Bello, Mirella Lo Scrudato
  • Patent number: 10711245
    Abstract: The present invention relates to a method of converting human fibroblasts into neural stem cells, and more particularly, to a method of directly converting human fibroblasts into neural stem cells using only a combination of small-molecule compounds without any introduction of a foreign gene, and to the use of the neural stem cells. The method of directly converting human fibroblasts into neural stem cells using only small-molecule compounds without any introduction of a foreign gene makes it possible to obtain genetically stable neural stem cells in an amount sufficient for use in cell therapy by deriving them from human fibroblasts. The neural stem cells obtained according to the method of the present invention can differentiate into functional neural cells and are not tumorigenic. Thus, these neural stem cells are useful as cellular therapeutic agents for treatment of brain diseases.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: July 14, 2020
    Assignee: INSTEMCARE INC.
    Inventors: Sung Hoi Hong, Kyung-Ah Choi, In Sik Hwang
  • Patent number: 10472396
    Abstract: The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia Rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: November 12, 2019
    Assignee: CELLECTIS
    Inventors: Claudia Bertonati, Philippe Duchateau, Alexandre Juillerat, George Silva, Julien Valton
  • Patent number: 9873894
    Abstract: Methods and compositions comprising single guide RNAs targeted to an endogenous mammalian ? globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia 11A (BCL11A) gene, Kruppel-like factor 1 (KLF1) gene, CCR5 gene, CXCR4 gene, PPP1R12C (AAVS1) gene, hypoxanthine phosphoribosyltransferase (HPRT) gene, albumin gene, Factor VIII gene, Factor IX gene, Leucine-rich repeat kinase 2 (LRRK2) gene, Hungtingin (Htt) gene, rhodopsin (RHO) gene, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, surfactant protein B gene (SFTPB), T-cell receptor alpha (TRAC) gene, T-cell receptor beta (TRBC) gene, programmed cell death 1 (PD1) gene, Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene, human leukocyte antigen (HLA) A gene, a LMP7 gene, a Transporter associated with Antigen Processing (TAP) gene, tapasin gene (TAPBP), a class II major histocompatibility complex transactivator (CIITA) gene, a dystrophin gene (DMD), a glucocorticoid receptor gene (GR), IL2RG gene or RFX5 for genetic alteration of cells a
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: January 23, 2018
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Anthony Conway, Gregory J. Cost, Russell Dekelver, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Jianbin Wang, H. Steve Zhang
  • Publication number: 20150099273
    Abstract: The present invention relates to a bacterial cell with texturizing property, starter cultures comprising the cell, and dairy products fermented with the starter culture.
    Type: Application
    Filed: September 29, 2014
    Publication date: April 9, 2015
    Applicant: CHR. HANSEN A/S
    Inventors: Thomas JANZEN, Ditte Ellegaard CHRISTIANSEN
  • Patent number: 8999653
    Abstract: The instant invention provides for methods for detecting the internalization of a transmembrane protein of interest expressed at the surface of a cell. More specifically, the methods involve (a) labelling the protein of interest with a fluorescent metal complex, the lifetime of which is greater than 0.1 ms, (b) adding to the reaction medium a composition capable of causing the internalization of the protein of interest, (c) adding to the reaction medium (1) a modulating agent which is a fluorescent FRET acceptor compound compatible with the fluorescent metal complex, the final concentration of which in the reaction medium is greater than 10?7M; or (2) a reducing agent, the redox potential of which is less than +0.1 V and preferably between 0.25 and 0.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: April 7, 2015
    Assignee: Cis-Bio International
    Inventors: Jurriaan Zwier, Robert Poole, Herve Ansanay, Michel Fink, Eric Trinquet
  • Publication number: 20150082478
    Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed.
    Type: Application
    Filed: August 20, 2014
    Publication date: March 19, 2015
    Inventors: Andrew Mark Cigan, Saverio Carl Falco, Huirong Gao, Zhongsen Li, Zhan-Bin Liu, L. Aleksander Lyznik, Jinrui Shi, Sergei Svitashev, Joshua K. Young
  • Publication number: 20150004656
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 1, 2015
    Inventors: Lan Tang, Ye Liu, Junxin Duan, Yu Zhang, Christian Joergensen, Randall Kramer
  • Publication number: 20140356956
    Abstract: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding a nuclease-null Cas9 protein that binds to the DNA and is guided by the one or more RNAs, introducing into the cell a third foreign nucleic acid encoding a transcriptional regulator protein or domain, wherein the one or more RNAs, the nuclease-null Cas9 protein, and the transcriptional regulator protein or domain are expressed, wherein the one or more RNAs, the nuclease-null Cas9 protein and the transcriptional regulator protein or domain co-localize to the DNA and wherein the transcriptional regulator protein or domain regulates expression of the target nucleic acid.
    Type: Application
    Filed: June 30, 2014
    Publication date: December 4, 2014
    Inventors: George M. CHURCH, Prashant G. MALI, Kevin M. ESVELT
  • Publication number: 20140342457
    Abstract: A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
    Type: Application
    Filed: June 30, 2014
    Publication date: November 20, 2014
    Inventors: Prashant G. MALI, George M. CHURCH, Luhan Yang
  • Publication number: 20140342456
    Abstract: A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
    Type: Application
    Filed: June 30, 2014
    Publication date: November 20, 2014
    Inventors: Prashant G. MALI, George M. CHURCH, Luhan Yang
  • Publication number: 20140342369
    Abstract: The present invention relates to the generation of stable haploid cell cultures, uses of said cells in forward and reverse genetics, especially the identification of target genes associated with a modified phenotype and in particular identifying genetic targets associated with toxin resistance, especially ricin toxicity resistance, and therapeutic uses of target compounds.
    Type: Application
    Filed: November 30, 2012
    Publication date: November 20, 2014
    Applicant: IMBA - INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH
    Inventors: Ulrich Elling, Josef Penninger, Jasmin Taubenschmid
  • Publication number: 20140342408
    Abstract: Provided are isolated polypeptides having xylanase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains.
    Type: Application
    Filed: November 22, 2012
    Publication date: November 20, 2014
    Inventors: Yu Zhang, Lan Tang, Junxin Duan, Ye Liu
  • Publication number: 20140335618
    Abstract: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; ā€œTALENSā€) are provided.
    Type: Application
    Filed: April 14, 2014
    Publication date: November 13, 2014
    Applicants: Regents of the University of Minnesota, Iowa State University Research Foundation, Inc.
    Inventors: Daniel F. Voytas, Adam J. Bogdanove, Feng Zhang
  • Publication number: 20140335521
    Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided.
    Type: Application
    Filed: October 22, 2012
    Publication date: November 13, 2014
    Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Takahiro Nakamura, Yusuke Yagi, Keiko Kobayashi
  • Publication number: 20140322168
    Abstract: The present invention provides a newly isolated bacterial strain of Paenibacillus, designated Paenibacillus alvei strain TS-15 for use as a biocontrol agent in the inhibition and/or elimination of a human foodborne pathogen, e.g., Salmonella, on a plant or plant organ, e.g., a tomato or tomato plant. Strain TS-15 or mutants thereof may also be used in the control of plant pathogens.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 30, 2014
    Applicant: The United States of America, as represented by the Secretary, Department of Health & Human Servic
    Inventors: Eric W. Brown, Jie Zheng, Alexander Enurah
  • Publication number: 20140317786
    Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 23, 2014
    Inventor: Marc Morant
  • Publication number: 20140308705
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 16, 2014
    Inventors: Marc Morant, Tarana Shaghasi
  • Publication number: 20140301990
    Abstract: Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes.
    Type: Application
    Filed: March 20, 2014
    Publication date: October 9, 2014
    Inventors: Philip D. Gregory, Michael C. Holmes, David Paschon, Lei Zhang, Maria Chiara Bonini, Pietro Genovese, Zulma Magnani, Sara Mastaglio, Luigi Naldini
  • Publication number: 20140298535
    Abstract: Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis.
    Type: Application
    Filed: April 24, 2014
    Publication date: October 2, 2014
    Applicant: National Research Council of Canada
    Inventors: Jonathan Page, Andrea T. Todd
  • Publication number: 20140294785
    Abstract: Methods and compositions for reducing expression of genes on Chromosome 21 (ā€œChr 21ā€) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.
    Type: Application
    Filed: March 17, 2014
    Publication date: October 2, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Jeanne B. Lawrence, Jun Jiang, Lisa L. Hall
  • Publication number: 20140230083
    Abstract: The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia Rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.
    Type: Application
    Filed: July 24, 2013
    Publication date: August 14, 2014
    Applicant: CELLECTIS
    Inventors: Claudia Bertonati, Philippe Duchateau, Alexandre Juillerat, George Silva, Julien Valton
  • Publication number: 20140186957
    Abstract: The present invention provides compositions and methods for DNA targeting using TAL effectors and TAL effector based proteins, including but not limited to targeted gene regulation and targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides comprising a TAL effector or a TAL effector binding domain in combination with other domains, including but not limited to a cleavage domain. The TAL effector binding domain includes modifications that increase activity of the same and also remove the constraints that the DNA target sequence be preceded by a thymine.
    Type: Application
    Filed: January 3, 2013
    Publication date: July 3, 2014
    Applicants: Fred Hutchinson Cancer Research Center, Iowa State University Research Foundation, Inc.
    Inventors: Adam Joseph Bogdanove, Barry Leonard Stoddard, Philip H. Bradley, Erin Lynn Doyle
  • Publication number: 20140178955
    Abstract: The present invention provides the use of acid pretreated biomass such as jatropha seed cake, pongamia seed cake and banana stems as renewable feedstock for butanol production by the mutant Clostridium acetobutylicum MTCC 587. Chemical mutagenesis was carried out for improvement of the strain for better butanol tolerance and production. This present invention for the first time has reported an efficient process for high yield of butanol obtained in single batch fermentation using acid pretreated jatropha seed cake.
    Type: Application
    Filed: August 1, 2012
    Publication date: June 26, 2014
    Applicant: RELIANCE INDUSTRIES LIMITED
    Inventors: Vidhya Rangaswamy, Jasmine Isar, Harshvardhan Joshi
  • Patent number: 8748371
    Abstract: Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: June 10, 2014
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Rony Seger, Dana Chuderland
  • Patent number: 8735649
    Abstract: A series of independent non-transgenic mutations found at the waxy loci of wheat; wheat plants having these mutations in their waxy loci; and a method of creating and finding similar and/or additional mutations of the waxy by screening pooled and/or individual wheat plants. The wheat plants of the present invention exhibiting altered waxy activity in the wheat without having the inclusion of foreign nucleic acids in their genomes. The invention also includes food and non-food products as well as non-food products that incorporate seeds from the wheat plants having non-transgenic mutations in one or more waxy genes.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: May 27, 2014
    Assignee: Arcadia Biosciences, Inc.
    Inventors: Susan I Fuerstenberg, Ann J. Slade
  • Patent number: 8735683
    Abstract: A soybean cultivar designated 1906039 is disclosed. The invention relates to the seeds of soybean cultivar 1906039, to the plants of soybean cultivar 1906039, to the plant parts of soybean cultivar 1906039, and to methods for producing progeny of soybean cultivar 1906039. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 1906039. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 1906039, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 1906039 with another soybean cultivar.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: May 27, 2014
    Assignee: Mertec LLC
    Inventor: Jason Aaron Long
  • Publication number: 20140141516
    Abstract: The present invention relates to methods and compositions for engineering Clostridia species. In particular, embodiments of the present invention relate to the expression of recombinant resolvase proteins in Clostridia species.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 22, 2014
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Bryan P. Tracy, Eleftherios T. Papoutsakis
  • Patent number: 8729355
    Abstract: A soybean cultivar designated S110128 is disclosed. The invention relates to the seeds of soybean cultivar S110128, to the plants of soybean cultivar S110128, to the plant parts of soybean cultivar S110128, and to methods for producing progeny of soybean cultivar S110128. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S110128. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S110128, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S110128 with another soybean cultivar.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: May 20, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8722986
    Abstract: A soybean cultivar designated S100106 is disclosed. The invention relates to the seeds of soybean cultivar S100106, to the plants of soybean cultivar S100106, to the plant parts of soybean cultivar S100106, and to methods for producing progeny of soybean cultivar S100106. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S100106. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S100106, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S100106 with another soybean cultivar.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: May 13, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8722985
    Abstract: A soybean cultivar designated S100108 is disclosed. The invention relates to the seeds of soybean cultivar S100108, to the plants of soybean cultivar S100108, to the plant parts of soybean cultivar S100108, and to methods for producing progeny of soybean cultivar S100108. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S100108. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S100108, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S100108 with another soybean cultivar.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: May 13, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8722988
    Abstract: A soybean cultivar designated S100242 is disclosed. The invention relates to the seeds of soybean cultivar S100242, to the plants of soybean cultivar S100242, to the plant parts of soybean cultivar S100242, and to methods for producing progeny of soybean cultivar S100242. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S100242. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S100242, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S100242 with another soybean cultivar.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: May 13, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8722984
    Abstract: A soybean cultivar designated S100324 is disclosed. The invention relates to the seeds of soybean cultivar S100324, to the plants of soybean cultivar S100324, to the plant parts of soybean cultivar S100324, and to methods for producing progeny of soybean cultivar S100324. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S100324. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S100324, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S100324 with another soybean cultivar.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: May 13, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8722980
    Abstract: A soybean cultivar designated S090059 is disclosed. The invention relates to the seeds of soybean cultivar S090059, to the plants of soybean cultivar S090059, to the plant parts of soybean cultivar S090059, and to methods for producing progeny of soybean cultivar S090059. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S090059. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S090059, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S090059 with another soybean cultivar.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: May 13, 2014
    Assignee: Mertec, LLC
    Inventor: Patrick Joseph Arthur Grams
  • Patent number: 8722979
    Abstract: A soybean cultivar designated 1347284 is disclosed. The invention relates to the seeds of soybean cultivar 1347284, to the plants of soybean cultivar 1347284, to the plant parts of soybean cultivar 1347284, and to methods for producing progeny of soybean cultivar 1347284. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 1347284. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 1347284, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 1347284 with another soybean cultivar.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: May 13, 2014
    Assignee: Mertec, LLC
    Inventor: Patrick Joseph Arthur Grams
  • Patent number: 8722990
    Abstract: A soybean cultivar designated S110121 is disclosed. The invention relates to the seeds of soybean cultivar S110121, to the plants of soybean cultivar S110121, to the plant parts of soybean cultivar S110121, and to methods for producing progeny of soybean cultivar S110121. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S110121. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S110121, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S110121 with another soybean cultivar.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: May 13, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8722989
    Abstract: A soybean cultivar designated S100239 is disclosed. The invention relates to the seeds of soybean cultivar S100239, to the plants of soybean cultivar S100239, to the plant parts of soybean cultivar S100239, and to methods for producing progeny of soybean cultivar S100239. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S100239. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S100239, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S100239 with another soybean cultivar.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: May 13, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8716569
    Abstract: A soybean cultivar designated 11430023 is disclosed. The invention relates to the seeds of soybean cultivar 11430023, to the plants of soybean cultivar 11430023, to the plant parts of soybean cultivar 11430023, and to methods for producing progeny of soybean cultivar 11430023. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar 11430023. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar 11430023, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar 11430023 with another soybean cultivar.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: May 6, 2014
    Assignee: Mertec, LLC
    Inventor: Jason Aaron Long
  • Patent number: 8716570
    Abstract: A soybean cultivar designated S110127 is disclosed. The invention relates to the seeds of soybean cultivar S110127, to the plants of soybean cultivar S110127, to the plant parts of soybean cultivar S110127, and to methods for producing progeny of soybean cultivar S110127. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar S110127. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar S110127, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar S110127 with another soybean cultivar.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: May 6, 2014
    Assignee: M.S. Technologies LLC
    Inventor: Justin T. Mason
  • Patent number: 8691578
    Abstract: A method includes providing a eukaryotic cell including mutant mtDNA in which there is at least one mutation in the mtDNA, allowing the cell to come into contact with an active oxygen species or a chemical species that generates such an active oxygen species in the cell (e.g., hydrogen peroxide) and thereby changing the percentage of mutant mtDNA (mitochondrial genomic DNA) in the cell as a result of the contact. Also featured are cells obtained by the above-described method.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: April 8, 2014
    Assignees: National Center or Neurology and Psychiatry, Riken
    Inventors: Feng Ling, Takehiko Shibata, Rong Niu, Minoru Yoshida, Yu-ichi Goto
  • Publication number: 20140053287
    Abstract: This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 20, 2014
    Applicant: VERENIUM CORPORATION
    Inventors: David P. WEINER, Lishan ZHAO, Peter LUGINBUHL, Ellen BURKE, Toby H. RICHARDSON, Paula M. HICKS
  • Publication number: 20140038291
    Abstract: Described herein are reprogrammed cells, and methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also descried are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming. In particular embodiments the cells are Stem-Like Cells (SLCs), including Neural Stem-Like Cells (NSLCs), Cardiac Stem-Like Cells (CSLC), Hematopoietic Stem-Like Cells (HSLC), Pancreatic Progenitor-Like Cells, and Mesendoderm-like Cells. Also described are methods for generating these cells from human somatic cells and other types of cells. Also provided are compositions and methods of using of the cells so generated in human therapy and in other areas.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 6, 2014
    Applicant: New World Laboratories Inc.
    Inventors: Jan-Eric Ahlfors, Rouwayda Elayoubi