Aids Related Test Patents (Class 435/974)
  • Patent number: 8609356
    Abstract: The invention relates to an in vitro method for detecting pulmonary arterial hypertension (PAHT), or the risk of developing PAHT, which includes determining the presence and/or amount of anti-tenascin C antibodies in a biological sample from a patient.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: December 17, 2013
    Assignees: Assistance Publique-Hopitaux de Paris, Universite Paris Descartes, Universite Paris-Sud 11
    Inventors: Luc Mouthon, Marc Humbert, Mathieu Tamby
  • Patent number: 8062908
    Abstract: A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said oral cavity; and (c) determining the presence or absence of at least one analyte.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: November 22, 2011
    Assignee: OraSure Technologies, Inc.
    Inventors: Ronald W. Mink, Andrew S. Goldstein, Robert C. Bohannon
  • Patent number: 7955791
    Abstract: A test strip and method for detecting an analyte present in a sample.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: June 7, 2011
    Assignee: Relia Diagnostic Systems
    Inventors: Robert K. Dinello, Alan J. Polito, Stella Quan
  • Patent number: 7741027
    Abstract: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: June 22, 2010
    Assignees: Gen-Probe Incorporated, BioMerieux S.A.
    Inventors: Yeasing Y. Yang, Steven T. Brentano, Odile Babola, Nathalie Tran, Guy Vernet
  • Patent number: 7541194
    Abstract: A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: June 2, 2009
    Assignee: Orasure Technologies, Inc.
    Inventors: Ronald W. Mink, Andrew S. Goldstein, Robert C. Bohannon
  • Patent number: 7521196
    Abstract: A test strip and method for detecting an analyte present in a sample.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: April 21, 2009
    Assignee: ReLia Diagnostic Systems, LLC
    Inventors: Robert K. Dinello, Alan J. Polito, Stella Quan
  • Patent number: 7442525
    Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: October 28, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Paul A. Luciw, Dino Dina, Kathelyn Steimer, Ray Sanchez Pescador, Carlos George-Nascimento, Deborah Parkes, Rob Hallewell, Philip J. Barr, Martha Truett
  • Patent number: 7408053
    Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: August 5, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Paul A. Luciw, Dino Dina
  • Patent number: 7374877
    Abstract: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: May 20, 2008
    Assignees: Gen-Probe Incorporated, BioMerieux S.A.
    Inventors: Yeasing Y. Yang, Steven T. Brentano, Odile Babola, Nathalie Tran, Guy Vernet
  • Patent number: 7309611
    Abstract: A test strip and method for detecting an analyte present in a sample.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: December 18, 2007
    Assignee: Relia Diagnostic Systems, LLC
    Inventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
  • Patent number: 7285271
    Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 23, 2007
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Paul A. Luciw, Dino Dina
  • Patent number: 7273695
    Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: September 25, 2007
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Paul A. Luciw, Dino Dina
  • Patent number: 7270995
    Abstract: The present invention is an analytical device which comprises a porous piece assembly consisting of a liquid reagent-receiving porous piece (1), a labeled substance-retaining piece (2), a test piece (3) comprising a detection site (4) and a reference site (5), and a sample-absorbing porous material piece (6); and a sample-receiving porous material piece (7) disposed independently therefrom and partially communicated therewith through a connection. The analytical device of the present invention exhibits extremely high sensitivity and can accurately perform various types of analysis.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: September 18, 2007
    Assignee: Nichirei Biosciences
    Inventors: Hirohisa Matsushita, Hidenori Kawai, Takashi Kitoh
  • Patent number: 7229839
    Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: June 12, 2007
    Assignee: Relia Diagnostic Systems, LLC
    Inventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
  • Patent number: 7205101
    Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: April 17, 2007
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: Paul A. Luciw, Dino Dina
  • Patent number: 7097971
    Abstract: The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective prophylactic and therapeutic vaccine against HIV. The peptides are based on conserved regions of HIV Tat and Rev, regulatory proteins and Nef, auxiliary proteins. Antigens in free- or carrier-bound form comprising at least one of the said peptides, vaccine compositions containing at least one of the antigens, immunoassay kits and a method of detecting antibodies induced by HIV or HIV specific peptides using such antigens, are described.
    Type: Grant
    Filed: September 3, 2001
    Date of Patent: August 29, 2006
    Assignee: Bionor Immuno AS
    Inventor: Birger Sorensen
  • Patent number: 7087377
    Abstract: The invention relates to an anti HIV 1 vaccine comprising the entire or part of the Tat HIV 1 protein, in addition to the identification of said protein in individuals affected by HIV. The Tat protein is a protein of the HIV 1 Oyi variant.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: August 8, 2006
    Assignee: Centre National de la Recherche Scientifique
    Inventor: Erwann Loret
  • Patent number: 7074554
    Abstract: Materials and methods are provided to inhibit HIV replication in targeted host cells.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: July 11, 2006
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Tsuneya Ikezu, Gary Leisman, Kimberly A. Carlson, Howard E. Gendelman
  • Patent number: 7070943
    Abstract: Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are described that permit the hypophosphorylated, active, form of pRB to be measured either as an absolute quantity or as a proportion of total cellular pRB. Further described are methods that permit pRB phosphorylation status to be correlated with cell cycle phase and with protein components of the cell cycle. Screening of chemical compounds for antiproliferative and antineoplastic activity using the flow cytometric assays is demonstrated. Reagent kits that facilitate the subject methods are also provided.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: July 4, 2006
    Assignee: Becton Dickinson and Company
    Inventors: Zbigniew Darzynkiewicz, Frank Traganos, Gloria Juan, Stefan Gruenwald
  • Patent number: 6974866
    Abstract: A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European collection of animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: December 13, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Hans-Peter Hauser, Stefan Knapp, Stefan Brust, Lutz G. Gürtler, Josef Eberle, Lazare Kaptue, Léopold Achenqui Zekeng
  • Patent number: 6949337
    Abstract: The present invention provides methods of identifying anti-HIV compound by contacting human Vpr Interacting Protein (hVIP), or a fragment thereof known to interact with Vpr, with Vpr, or a fragment thereof known to interact with hVIP in the presence of a test compound, and comparing the affinity of the hVIP or fragment thereof to the Vpr or fragment thereof in the presence of the test compound with the affinity of the hVIP or fragment thereof to the Vpr or fragment thereof in the absence of the test compound. The present invention also provides transgenic non-human mammals comprising a recombinant expression vector that comprises a nucleic acid sequence that encodes hVIP.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: September 27, 2005
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Velpandi Ayyavoo, Sundarasamy Mahalingam, Mamata Patel
  • Patent number: 6946254
    Abstract: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: September 20, 2005
    Assignees: Gen-Probe Incorporated, Biomerieux S.A.
    Inventors: Yeasing Y. Yang, Steven T. Brentano, Odile Babola, Nathalie Tran, Guy Vernet
  • Patent number: 6902884
    Abstract: Method of diagnosing and/or prognosticating HIV infection in a subject comprising the steps of: (a) performing in vitro a measurement of the level of a marker in the form of (i) urokinase plasminogen activator receptor (uPAR), (ii) soluble urokinase plasminogen activator receptor (suPAR), (iii) urokinase-type plasminogen activator (uPA), (iv) one or more degradation products of (i), (ii), or (iii), and/or (v) an mRNA for (i), (ii) or (iii), in a biological fluid sample from a subject, and (b) using the measurement value obtained to evaluate the state of the subject.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: June 7, 2005
    Assignee: Virogates ApS
    Inventor: Jesper Eugen-Olsen
  • Patent number: 6858400
    Abstract: In order to accurately and reliably quantitate HLE on the plasma membranes of the lymphocytes and mononuclear phagocytes, a test sample containing the lymphocytes and mononuclear phagocytes is initially treated with a first antiserum specific for CD4 receptors on the plasma membrane or with a second antiserum specific for chemokine receptors on the plasma membrane. Once the CD4 or chemokine receptors have been rendered non-reactive (competitive) relative to the HLE receptors (also “binding sites”) on the plasma membrane, the test sample is contacted with an immunoreagent specific for interaction with one or more of the HLE receptors on the plasma membranes of the lymphocytes and mononuclear phagocytes. The immunoreagent forms a complex with the HLE binding sites and produces a characteristic physical change in the lymphocytes and mononuclear phagocytes that can be monitored by any one of a number of standard techniques, (e.g., confocal laser scanning microscopy and flow cytometry).
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: February 22, 2005
    Inventor: Cynthia L Bristow
  • Patent number: 6815217
    Abstract: A solid phase with at least one test area is described which contains reagents for the detection of at least one analyte in a sample, wherein the solid phase additionally comprises at least one control area for the detection of interfering reactions.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: November 9, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Johann Karl, Helmut Lenz, Friedemann Krause, Peter Finckh, Hans Hornauer, Johann Berger
  • Patent number: 6767710
    Abstract: A test strip and method for detecting an analyte present in a sample.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: July 27, 2004
    Assignee: PraxSys BioSystems, LLC
    Inventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
  • Patent number: 6699656
    Abstract: The present invention relates to &bgr;-hCG, particularly &bgr;-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention of HIV infection by administration of a therapeutic compound of the invention. Such therapeutic compounds include hCG, &bgr;-hCG and &bgr;-hCG peptides, analogs and derivatives of hCG, &bgr;-hCG and &bgr;-hCG peptides, and nucleic acids encoding hCG, &bgr;-hCG and &bgr;-hCG peptides. In a preferred embodiment, &bgr;-hCG peptides, particularly &bgr;-hCG peptides of amino acids 47-53, 45-57 or 45-58 are administered to a subject for treatment or prevention of HIV infection in that subject. The invention also provides methods for screening hCG preparations for activity in treating or preventing HIV infection. Pharmaceutical compositions and methods of administration of Therapeutics are also provided.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: March 2, 2004
    Assignee: University of Maryland Biotechnology Institute
    Inventors: Robert C. Gallo, Joseph Bryant, Yanto Lunardi-Iskandar
  • Patent number: 6664042
    Abstract: The present invention provides a method for determining viral load in a patient infected with human immunodeficiency virus, which is useful in patients where viral loads are not detectable in plasma. The levels of human immunodeficiency virus are measured in CD4−CD8− double negative cells. Furthermore, the invention also provides a kit for determining viral load in a patient infected with human immunodeficiency virus.
    Type: Grant
    Filed: November 23, 2001
    Date of Patent: December 16, 2003
    Assignee: Cornell Research Foundation, Inc.
    Inventor: David N. Posnett
  • Patent number: 6653066
    Abstract: Disclosed is a device and method of use for detecting polyvalent analytes such as antibody to the AIDS virus, utilizing an inverse sandwich method. The test device comprises a first substance having an epitope, bound to a label and capable of moving within the test device. The test device further comprises a second substance immobilized to the test device and spatially separated from the first substance. The second substance has an epitope substantially similar to the epitope of the first substance. Upon application to the test device, the polyvalent analyte binds to the first substance and moves within the test device to the location of the second substance with both polyvalent analyte and first substance are immobilized at location of the second substance. Polyvalent analyte is detected by the presence of the label at the location of the second substance. Also disclosed is a control substance for use with the device that can be used to determine completion of the test and viability of the device.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: November 25, 2003
    Assignee: Trinity Biotech
    Inventor: Siegfried R. Krutzik
  • Publication number: 20030207252
    Abstract: Pharmaceutical compositions comprising the HIV protein vpr or nucleic acid molecule encoding vpr are disclosed. Also disclosed are methods of treating patients suffering from diseases characterized by hyperproliferating undifferentiated cells such as cancer by administering such compositions. Methods of identifying compounds which have anti-HIV activity are disclosed, in particular, methods of identifying compounds which modulate the activity of vpr and of identifying compounds which inhibit vpr binding to the HIV protein gag.
    Type: Application
    Filed: August 22, 2001
    Publication date: November 6, 2003
    Inventors: David B. Weiner, David Nathan Levy, Yosef Refaeli
  • Publication number: 20030180759
    Abstract: The current invention relates to new HIV-1 group O antigens, nucleic acids encoding them, and the use of said antigens and/or nucleic acids as reagents in the diagnosis and prophylaxis of AIDS. It also relates to new HIV-1 group O strains comprising these antigens.
    Type: Application
    Filed: December 16, 2002
    Publication date: September 25, 2003
    Applicant: INNOGENETICS N.V.
    Inventors: Eric Delaporte, Martine Peeters, Eric Saman, Marleen Vanden Haesevelde
  • Publication number: 20030129628
    Abstract: The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosis, monitoring and treatment of HIV-related diseases through the use of this antibody or related compounds.
    Type: Application
    Filed: October 15, 2002
    Publication date: July 10, 2003
    Inventors: Sybille Muller, Haitao Wang
  • Publication number: 20030129746
    Abstract: Antibodies to two new epitopes on the HCV envelope proteins were identified which allow routine detection of native HCV envelope antigens, in tissue or cells derived from the host. The new epitopes are: the E1 region aa 307-326 and the N-terminal hyper variable region of E2 aa 395-415. Surprisingly, we characterised an antibody that reacts with various sequences of the hypervariable domain of E2. Specific monoclonal antibodies directed against these epitopes and allowing routine detection of viral antigen are described.
    Type: Application
    Filed: December 13, 2002
    Publication date: July 10, 2003
    Applicant: INNOGENETICS N.V.
    Inventors: Geert Maertens, Erik Depla, Marie-Ange Buyse
  • Patent number: 6582928
    Abstract: The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.
    Type: Grant
    Filed: March 2, 2000
    Date of Patent: June 24, 2003
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Steven M. Chamow, Timothy P. Kogan
  • Patent number: 6582920
    Abstract: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are disclosed.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: June 24, 2003
    Assignees: Gen-Probe Incorporated, Biomerieux S.A.
    Inventors: Yeasing Y. Yang, Steven T. Brentano, Odile Babola, Nathalie Tran, Guy Vernet
  • Patent number: 6548635
    Abstract: A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: April 15, 2003
    Assignee: Dade Behring Marburg GmbH
    Inventors: Hans-Peter Hauser, Stefan Knapp, Stefan Brust, Lutz G. Gürtler, Josef Eberle, Lazare Kaptue, Léopold Achengui Zekeng
  • Patent number: 6541609
    Abstract: A substantially pure polypeptide having at least one antigenic determinant that is substantially identical to an antigenic determinant of a protein from a cell line infected with simian T-lymphotrophic virus-III or human T-lymphotrophic virus-IV (HTLV-IV), also known as HIV-2, the protein being selected from: a) a glycoprotein having a molecular weight (m.w.) of about, 160,000 daltons; a glycoprotein having a m.w. of about 120,000 daltons; a gag protein having a m.w. of about 55,000 daltons; a gag protein having a m.w. of about 24,000 daltons; and a glycoprotein having a m.w. of about 32,000 daltons. Also disclosed are various methods of immunoassay using that peptide or antibodies raised to it. Finally, immunoassays for simian specimens are disclosed using peptides that are immunologically cross-reactive with the above-described peptide, or antibodies thereto.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: April 1, 2003
    Assignee: President and Fellows of Harvard College
    Inventors: Myron E Essex, Phyllis J Kanki
  • Patent number: 6528323
    Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: March 4, 2003
    Assignee: Praxsys Biosystems, Inc.
    Inventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
  • Publication number: 20030039663
    Abstract: A vaccine and a method of raising neutralizing antibodies against HIV infection. The vaccine comprises a complex of gp120 covalently bonded to CD4 or to succinyl concanavalin A. Also disclosed are immunological tests using the complex or antibody thereto for detection of HIV infection.
    Type: Application
    Filed: July 17, 2001
    Publication date: February 27, 2003
    Inventors: Anthony L. Devico, Ranajit Pal, Mangalasseril G. Sarngadharan
  • Patent number: 6518015
    Abstract: This invention includes a peptide comprising the sequence CAFRQVC and an antigenic composition using the same. It also includes an in vitro method of detecting HIV-1 and HIV-2 antibodies in a sample using the peptide, and a kit for carrying out the method.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: February 11, 2003
    Assignee: Institut Pasteur
    Inventors: Marc Alizon, Luc Montagnier, Denise G Guétard, Francois Clavel, Pierre Sonigo, Mireille Guyader
  • Patent number: 6511801
    Abstract: The claimed invention relates to an HIV-1 group O envelope antigen comprising SEQ ID NO: 100, and the use of said antigen as a reagent in the diagnosis of HIV-1 group O infection, and a kit therefore.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: January 28, 2003
    Assignee: Innogenetics, N.V.
    Inventors: Eric DeLaporte, Martine Peeters, Eric Saman, Marleen Vanden Haesevelde
  • Patent number: 6503702
    Abstract: The present invention is drawn to an immunoassay capable of the rapid detection of a variety of test substances that may be present in a test sample. One feature of the invention is that extraction or isolation of the test substance occurs simultaneously with the formation of the primary antigen-test substance complex. The primary antigen-test substance complex is then captured in a solid phase format having a plurality of interstitial spaces which facilitate rapid and efficient detection. The immunoassay of the present invention works over a wide range of environmental conditions and is simple enough to be used in the absence of laboratory facilities.
    Type: Grant
    Filed: November 4, 1997
    Date of Patent: January 7, 2003
    Assignee: Syngenta Investment Corporation
    Inventor: Sandy J. Stewart
  • Publication number: 20030003442
    Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
    Type: Application
    Filed: June 22, 2001
    Publication date: January 2, 2003
    Applicant: Dade Behring Marburg GmbH
    Inventors: Lutz G. Guertler, Josef Eberle, Albrecht V. Brunn, Stefan Knapp, Hans-Peter Hauser
  • Patent number: 6489131
    Abstract: The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid a hook effect. The invention in addition concerns suitable reagent kits for carrying out the method.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: December 3, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Rainer Wehner, Frederic Donie, Beatus Ofenloch-Hähnle
  • Patent number: 6465173
    Abstract: The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosis, monitoring and treatment of HIV-related diseases through the use of this antibody or related compounds.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: October 15, 2002
    Assignee: Immune Research, Ltd.
    Inventors: Sybille Müller, Haitao Wang
  • Patent number: 6465172
    Abstract: A vaccine and a method of raising neutralizing antibodies against HIV infection. The vaccine comprises a complex of gp120 covalently bonded to CD4 or to succinyl concanavalin A. Also disclosed are immunological tests using the complex or antibody thereto for detection of HIV infection.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: October 15, 2002
    Assignee: bioMérieux, Inc.
    Inventors: Anthony L. Devico, Ranajit Pal, Mangalasseril G. Sarngadharan
  • Patent number: 6458548
    Abstract: A container for measurement of cell functions, for use in the determination of a physiologically active substance produced by blood cells, is constituted such that an amount of material capable of inducing production of the physiologically active substance, when extracted by collecting water of a volume equal to a liquid volume to be subjected to measurement, is controlled at a level insufficient to induce production of the physiologically active substance from the blood cells. A container for measurement of cell functions in which a material capable of inducing production of a physiologically active substance in blood when contacted with the blood is accommodated in such a condition as being contactable with blood, and in which an amount of the material capable of inducing production of the physiologically active substance in the container before use is limited to a level insufficient to influence a measured value of the physiologically active substance.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: October 1, 2002
    Assignee: Sekisui Kagaku Kogyo Kabushiki Kaisha
    Inventors: Koji Kobayashi, Yuji Setoguchi, Kiyoshi Kuriyama
  • Publication number: 20020086283
    Abstract: The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.
    Type: Application
    Filed: September 24, 2001
    Publication date: July 4, 2002
    Inventors: Barton F. Haynes, Dhavalkumar D. Patel, Munir Alam, Hua-Xin Liao
  • Patent number: RE38688
    Abstract: A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: January 18, 2005
    Assignee: Dade Behring Marburg GmbH
    Inventors: Heinz-Jürgen Friesen, Gerd Grenner, Hans-Erwin Pauly, Helmut Kohl, Klaus Habenstein, Joseph Stärk
  • Patent number: RE37918
    Abstract: This invention relates to a methodology for assessing the sensitivity of an HIV-1 sample to zidovudine and to diagnostic assays for use in such assessment.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: December 3, 2002
    Assignee: Glaxo Wellcome, Inc.
    Inventors: Brendan A. Larder, Sharon D. Kemp nee Symons