Abstract: A molecular detection apparatus according to an embodiment includes a detector and a discriminator. The detector includes a plurality of detection cells, where the plurality of detection cells include at least an organic probe containing a cyano group or a nitro group as a neighboring group of a reactive group. The discriminator discriminates a substance to be detected by signal patterns of the plurality of detection cells.

Abstract: A method for determining a concentration of a scale inhibitor in a water system that includes contacting a scale inhibitor with a dye in a capillary channel to form a complex effective to generate fluorescence; measuring a fluorescence signal generated by the complex; and, determining the concentration of the scale inhibitor based on the fluorescence signal.

Abstract: An integrated sensor of volatile organic gas can include a photoionization detector (PID) and one or more additional detectors such as an infrared detector, a catalytic combustion detector, or an electrochemical detector. One embodiment includes a methane detector that allows correction of the PID measurements for the interference of methane with the PID and/or allows a combination of measurements of the sensors to measure a total hydrocarbon concentration. A further sensor of non-hydrocarbon quenching gases such as carbon dioxide may also be used in correction of the PID measurements.

Abstract: An electrochemical sensor of a downhole tool positionable in a wellbore penetrating a subterranean formation is provided. The downhole tool has a flowline to receive downhole fluid. The electrochemical sensor includes a bulkhead carried by the downhole tool, a membrane exposed to the downhole fluid in the flowline, and an electrochemical cell supported by the bulkhead about the membrane. The electrochemical cell includes a plurality of cell sensors, at least one cell electrode, and a sensing solution. The plurality cell sensors include an analyte sensor, a temperature sensor, and a pH sensor. The sensing solution is reactive to certain analytes in the downhole fluid to generate electrical signals measurable by the plurality of cell sensors whereby parameters of chemicals in the downhole fluid may be measured.

Abstract: A system for determining an analyte by inductively coupled plasma mass spectrometry (ICPMS) includes a sample introduction device having a heated cyclonic spray chamber. The system is configured to introduce sample that includes a metal and/or a metalloid having an organic interferent. The system also includes an inductively coupled plasma mass spectrometry device with a collision/reaction cell configured to receive a mixture of gases including both ammonia and hydrogen. A method includes introducing a sample to plasma to produce a characteristic spectrum associated with an elemental composition of the sample. The method also includes introducing both ammonia and hydrogen to a collision/reaction cell to remove carbon-based interferences to detection of the sample prior to determining the elemental composition of the sample.

Abstract: This disclosure provides methods to use nanoparticles as non-optical tags for detecting a change in mass. chemical sensing or bio-sensing events or reaction upon conjugation of nanoparticles onto a thermoresistor heat sensor. Particularly described is the use of metal nanoparticles in thermal sensors, thermal bio-sensors, and sensing pixel arrays for multiple analyte sensing. In addition, an asymmetric filter is disclosed that allows size separation of molecules from nanoparticles. The asymmetric filter is a porous membrane that is designed to have a small pore size in one size and a large pore size on the other side.

Abstract: A method for treating depression using a biomarker includes measuring a level of phosphoethanolamine in a blood sample collected from a subject, comparing the level of phosphoethanolamine in the blood sample with a predetermined threshold, in response to the level of phosphoethanolamine in the blood sample being below the predetermined threshold, determining that the subject requires a treatment for depression, and treating the subject determined to suffer from depression.

Abstract: Methods and systems described herein include individual-use beverage containers including sensors and methods of their use. Beverage containers include: a vessel body configured to hold a beverage; and at least one sensor associated with the vessel body, the at least one sensor including a sensor configured to detect one or more substance in a fluid. Systems include: at least one beverage container including at least one sensor configured to detect one or more substance in fluid; and at least one external device including at least one port configured for communication with the at least one sensor. Methods include: detecting one or more substance within fluid with at least one sensor integral to a beverage container; and interfacing one or more of the at least one sensor with an external device.

Abstract: A method to determine the strength of an acid in a medium is disclosed. The method includes (I) providing multiple samples comprising trimethylphosphine oxide (TMPO), the acid, and the medium, wherein the multiple samples have different [H+]/[TMPO] ratios, [H+] is the concentration of hydrons in the sample in mole.liter?1, and [TMPO] is the concentration of TMPO in the sample in mole.liter?1. (II) The 31P chemical shifts of the multiple samples are measured by 31P NMR and compared to standardized samples to determine the acid strength of the medium.

Abstract: To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker. The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD+, and a substance involved in the metabolism of any of these substances.

Abstract: Certain embodiments of the present invention relate to the preparation of microbeads that exhibit a “turn on” fluorescence response within seconds of exposure to an analyte vapor (e.g., a chemical warfare agent or a reactive stimulant). This sensing approach is modeled after the mechanism for inhibition of acetylcholinesterase enzyme activity, and utilizes a specific and irreversible reaction between phosphonyl halides and a fluorescent indicator. The present invention also relates to a sensor and a method for sensing an analyte through detection of changes in the fluorescing properties of the inventive microbeads.

Abstract: Methods and devices for determining a preferred composition of anions in a liquid crystal device, and methods and devices for detecting a targeted agent in a sample using such preferred compositions, are disclosed. Such methods include the steps of preparing a liquid crystal device including a liquid crystal, a metal cation, a strongly coordinating anion, and a weakly coordinating anion, contacting the liquid crystal device with a sample suspected of including the targeted agent, and observing the orientational ordering of the liquid crystal at the surface.

Abstract: A photoconductive sensor compound for detecting explosives can have a structure I: where R is a morphology control group, A is a linking group, B is a electron donor that is selective for transferring electrons to PTCDI backbone upon irradiation to make the resulting nanostructures conductive, and R1 through R8 are side groups.

Abstract: The present invention relates to a novel cyanne derivative having a meso-reaction functional group in a polymethine chain, and a preparation method thereof, and the cyanine derivative having the reaction functional group substituted at the meso site may be suitable for mass production thanks to a very simple synthesis method, have a very fast reaction rate because while a related art reagent for detection of nerve agents undergoes two steps of reactions, the cyanine derivative of the present invention undergoes only one step of reaction, have very excellent sensitivity, and be useful as an acid pH-activated ratiometric NIR probe because it is able to be activated in an acidic pH and is usable in an aqueous environment.

Abstract: The invention provides methods for isolating a target molecule from a sample. In an embodiment, the method involves contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation, under conditions wherein the agent is capable of binding a target molecule to form a target molecule-capture agent complex, wherein the target molecule is selected from the group consisting of a phosphorylated molecule, a nitrotyrosine-containing molecule and a sulfated molecule, and separating the target molecule-capture agent complex from the sample, thereby isolating the target molecule from the sample. Also provided are methods for determining the presence of a target molecule in a sample, that involve contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation.

Abstract: Methods and systems described herein include beverage immersates and methods of their use. Systems include: at least one beverage immersate, wherein the at least one beverage immersate includes at least one sensor configured to detect at least one analyte in a fluid within a personal use beverage container; and at least one signal transmitter configured to transmit a signal responsive to the at least one beverage immersate. Methods include: detecting one or more analyte in fluid within a personal use beverage container with at least one sensor integral to at least one beverage immersate; and communicating data from the at least one beverage immersate to at least one device external to the beverage immersate.

Abstract: A method of monitoring a surfactant in a microelectronic process is disclosed. Specifically, the monitoring of a surfactant occurs by studying the fluorescence or electromagnetic emission of a sample collected from a microelectronic process.

Abstract: The scale inhibitors in a variety of aqueous systems, or a part or sample thereof, also including one or more dissolved interfering ions, are separated therefrom and analyzed, such scale inhibitors comprising a polymer containing at least one anionic functional group, e.g., a strong acid functional group or a phosphonate or phosphate ester, and such analysis including treating these aqueous systems with a cationic substrate or a free cation.

Abstract: One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.

Abstract: The present invention relates to a method of improving detection sensitivity of an ion mobility spectrometer, comprising: inserting a sample into a sample receiving device of the ion mobility spectrometer; triggering an operation of spectra acquisition through an optocoupler; when the number of the acquired spectra reaches the level required to contain enough information for accurate detection of explosives with relatively high vapor pressure, adding a dopant instantly to the ionization region by controlling the ON/OFF-state of an electromagnetic valve; when the number of the acquired spectra reaches the level required to contain enough information for accurate detection of explosives with relatively low vapor pressure, stopping the acquisition operation, and turning off the electromagnetic valve so as to stop adding the dopant to the ionization region; analyzing all of the acquired spectra to obtain the detection result.

Abstract: The invention relates to kits and methods of collecting and detecting alkyl methylphosphonic acids from environmental or biological liquids using a sorbent material. The sorbent material may be transported, desorbed and tested for alkyl methylphosphonic acids.

Abstract: Methods for detecting particles in a fluid, including determining particle size and intrinsic fluorescence of a particle, and time correlating the particle detection data with image data in the vicinity of the detector or detector inlet to identify contamination sources in clean environments are described.

Abstract: A sensor device includes an optical limiting structure including a metal layer with at least one metal particle having a size no greater than about 1500 nanometers, and a phase-change material layer disposed adjacent at least a portion of the metal layer, the phase-change material layer including a phase-change material, and a dendritic-metal layer disposed over at least a portion of the phase-change material layer of the optical limiting structure, the dendritic-metal layer including an organic compound including branching chain amino acid groups attached to a metal structure. The optical limiting structure is configured to transition from a first optical state to a second optical state when the phase-change material is heated above a critical temperature, with transmittance of light at a predetermined wavelength through the optical limiting structure being lower at the second optical state of the optical limiting structure in relation to the first optical state of the optical limiting structure.

Abstract: A field colorimetric test device includes a housing having at least one interior compartment. A sampling device is configured to be associated with a distal end of the housing. A selection device is attached to a proximal end of the housing.

Abstract: The present invention relates to the fields of genetics, immunology and medicine. The present invention more specifically relates to the identification of human genes and expression products thereof which can be used to assess the prognosis of a cancer in a subject, to assess the sensitivity of a subject to a treatment of cancer, or monitor, in particular determine the efficacy, of such a treatment of cancer after a given period of time. Said human genes and expression products can further be used (i) in the prevention or treatment of cancer, in particular to determine or select the appropriate cancer treatment for a given subject and/or for a particular tumor, as well as (ii) for the screening of therapeutically active drugs.

Abstract: A chemical sensor having a sol-gel material affixable to a predetermined surface, and an indicator within the sol-gel, for detecting and signaling the presence of at least one chemical is provided. Also provided is an indicator for detecting and indicating a presence of at least one chemical. The indicator includes a sol-gel material affixable to a predetermined surface and an indicator within the sol-gel, for detecting and signaling the presence of at least one chemical. There is provided a method of detecting at least one chemical by applying the indicator from above to a predetermined surface of an object and indicating the presence of a chemical. A method of making a chemical sensor encapsulating within a sol-gel a detector capable of detecting and signaling a presence of at least one chemical.

Abstract: The present invention relates to a method and device for the detecting and/or electrically quantifying organophosphorus compounds as a gas or solution. The device includes: an electrical device including a source electrode and a drain electrode, separated by a semiconductor material; and a device for detecting positive charges between the two electrodes. One surface of the semiconductor material is in contact with a polymer material having at least one receptor group including: 1) a function X capable of reacting with the detectable organophosphorus compound, to form an intermediate grouping —Z; and 2) a function Y capable of reacting with —Z to form a positively charged ring. The polymer material includes molecular imprint cavities, with geometrical and chemical configuration allowing the detectable organophosphorus compounds to penetrate into said polymer material. The invention can be used in the field of detecting and/or quantifying organophosphorus compounds.

Abstract: There is provided a method of monitoring for the presence of phosphate esters in jet fuel. The method comprises obtaining from a jet fuel source a jet fuel test sample suspected of containing phosphate esters. The method further comprises combining the jet fuel test sample with a polar solvent and a nonpolar solvent to form a mixture. The method further comprises agitating the mixture. The method further comprises extracting the polar solvent from the mixture. The method further comprises performing a combined gas chromatography and mass spectrometer analysis of the polar solvent to monitor for the presence of any phosphate esters and to obtain an actual concentration level of any phosphate esters. The method further comprises comparing the actual concentration level of any phosphate esters with a calibration standard concentration of phosphate esters in clean jet fuel.

Abstract: A system for warning of corrosion, chemical, or radiological substances. The system comprises painting a surface with a paint or coating that includes an indicator material and monitoring the surface for indications of the corrosion, chemical, or radiological substances.

Abstract: A paint that warns of radiological or chemical substances comprising a paint operatively connected to the surface, an indicator material carried by the paint that provides an indication of the radiological or chemical substances, and a thermo-activation material carried by the paint. In one embodiment, a method of warning of radiological or chemical substances comprising the steps of painting a surface with an indicator material, and monitoring the surface for indications of the radiological or chemical substances. In another embodiment, a paint is operatively connected to a vehicle and an indicator material is carried by the paint that provides an indication of the radiological or chemical substances.

Abstract: An embodiment of a chemical detector has at least one detection window and at least first and second ampoules selectively communicatively coupled to the at least one detection window. The first ampoule contains a first substance that can hydrolyze a nerve agent. The second ampoule contains a second substance that can react with a hydrolyzed nerve agent to produce a color change.

Abstract: A photoconductive sensor compound for detecting explosives can have a structure I: where R is a morphology control group, A is a linking group, B is a electron donor that is selective for transferring electrons to PTCDI backbone upon irradiation to make the resulting nanostructures conductive, and R1 through R8 are side groups.

Abstract: A method of monitoring a surfactant in a microelectronic process is disclosed. Specifically, the monitoring of a surfactant occurs by studying the absorbance of a sample collected from a microelectronic process.

Abstract: The present invention generally relates to luminescent and/or optically absorbing compositions and/or precursors to those compositions, including solid films incorporating these compositions/precursors, exhibiting increased luminescent lifetimes, quantum yields, enhanced stabilities and/or amplified emissions. The present invention also relates to sensors and methods for sensing analytes through luminescent and/or optically absorbing properties of these compositions and/or precursors. Examples of analytes detectable by the invention include electrophiles, alkylating agents, thionyl halides, and phosphate ester groups including phosphoryl halides, cyanides and thioates such as those found in certain chemical warfare agents. The present invention additionally relates to devices and methods for amplifying emissions, such as those produced using the above-described compositions and/or precursors, by incorporating the composition and/or precursor within a polymer having an energy migration pathway.

Abstract: An assay for screening potential hydrolysis enhancing agents capable of facilitating the hydrolysis of a substantially water insoluble halogenated compound such as mustard gas (HD) in an aqueous reaction mixture is disclosed. The assay includes at least one chamber adapted for receiving and retaining the substantially water insoluble mustard gas compound and a potential hydrolysis agent in an aqueous reaction mixture, and a pH indicating agent adapted to produce a visible color change corresponding to the amount of the substantially water insoluble mustard gas compound hydrolyzed in the aqueous reaction mixture wherein the rate of hydrolysis can be established by measuring the change in the detectable signal over time.

Abstract: A method for fabricating a sensor material for detecting molecular contaminants, including the steps of: providing an aqueous solution of a metal oxide precursor; mixing titanium dioxide nanotubes with the aqueous solution of the metal oxide to form a mixture; adjusting a pH value of the mixture with a weak base until the pH value is neutral; dispersing the mixture in water and heating the mixture; and filtering the mixture to retain a solid part, and calcining the solid part under a continuous flow of oxygen to form metal oxide loaded titanium dioxide nanotubes. The disclosure also provides a sensor material and a detecting method using the sensor material for ppm-ppb-ppt concentration level detection of molecular contaminants.

Abstract: The invention provides an electrode comprising an electrically conductive material having a surface capable of producing surface enhanced Raman scattering of incident light from a complex adsorbed at the surface of the electrode, the complex including the electrically conductive material combined with a second material that is substantially reducible and not substantially oxidizable. The surface of the electrode can be microroughened. The invention also includes a method for making various embodiments of the electrode, and a method of generating electricity using the electrode. In accordance with a further aspect of the invention, a fuel cell is provided including the electrode of the invention.

Abstract: A layered adaptive membrane structure that has movable membranes is provided. The structure can change its gas, liquid and/or particulate permeability in response to surrounding environmental conditions. Applications include protective apparel that is comfortable to wear wherein the level of protection provided is based on conditions in the environment. Hence, the protective apparel is highly breathable and comfortable in a non-hazardous environment but impermeable or only semipermeable in a hazardous environment.

Abstract: The present invention relates to a method for determining the presence or amount of a compound in a sample by interparticle distance-dependent sensing, comprising: (a) contacting the sample suspected of containing the compound with rare earth doped metal oxide nanoparticles; and (b) detecting the compound by determining the change in luminescent properties of the rare earth doped metal oxide nanoparticles upon contact with the sample.

Abstract: The present invention is directed to a method for differentially diagnosing dementia or the risk of dementia in a patient. The method comprises obtaining a sample from the patient; analyzing the sample to obtain quantifying data for one or more than one metabolite marker; comparing the quantifying data for the one or more than one metabolite marker to corresponding data obtained from one or more than one reference sample; and using the comparison to differentially diagnose dementia or the risk of dementia. The method may also assist in assessing dementia or the risk of dementia in a patient. The present invention is also directed to metabolite markers and compounds useful in the present method.

Abstract: Compounds of formula I: wherein R1, R2, n and m are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.

Abstract: The present invention relates to the use of endogenous reference metabolites and a method for normalization of intensity data corresponding to amounts and/or concentrations of selected target metabolites in a biological sample of a mammalian subject, wherein said intensity data are obtained by a metabolomics analysis method with one or a plurality of endogenous reference metabolites, comprising carrying out at least one in vitro metabolomics analysis method of said selected target metabolites in said biological sample, simultaneously carrying out in the same sample a quantitative analysis of one or a plurality of endogenous reference metabolites or derivatives thereof, wherein said endogenous reference metabolites are such compounds in the biological sample which are present in the subject at an essentially constant level; and wherein said endogenous reference metabolites or derivatives thereof have a molecular mass less than 1500 Da.

Abstract: Biomarkers of pancreatic cancer are described, as well as methods using these compounds for detecting pancreatic cancer. The methods can be used to diagnose a patient's health state, or change in health state, or for diagnosing risk of developing or the presence of pancreatic cancer. The method comprises analyzing a sample from a patient to obtain quantifying data for one or more than one of the metabolite markers; comparing the quantifying data to corresponding data obtained for one or more than one reference sample to identify abnormalities in the level of the metabolite marker(s) in the sample; and making a diagnosis if an abnormality is observed. Standards and kits for carrying out the method are also described.

Abstract: A whispering gallery mode resonator based optical sensor assembly comprises a flow channel permeable to optical energy and first and second optical waveguides adjacent to a section of the flow channel and adapted to be in first and second evanescent field couplings respectively with the section such that the section forms a whispering gallery mode resonator. The resonator is responsive to an optical signal conveyed in the first optical waveguide and communicates a second optical signal to the second optical waveguide indicative of a resonance wavelength of the whispering gallery mode resonator. A detector optically coupled to the second optical waveguide detects the output signal. A signal processor detects a shift in the output signal responsive to an analyte fluid flowing through the flow channel. The shift is indicative of the identity of at least one constituent of the analyte fluid.

Abstract: Formats for optical analysis of fluid samples are provided with platforms and wells for contacting fluid samples and bringing reagents in contact with fluid samples. Formats may be made in opposing platform-and-well constructions, allowing a platform protruding from one format member to enter a well contained within an opposing format member. A sample fill nose accepts sample fluid from a sample collection opening and transports the sample fluid through the format.

Abstract: The invention relates to an apparatus and method for detecting and/or quantifying compounds of interest present in gaseous form or dissolved in a solvent. The apparatus according to the invention includes an electrical device including two electrodes, and a device for measuring the variation in charges between the two electrodes of the electrical device. The electrical device includes a layer made of an insulating dielectric material onto which a layer of receptor molecules is grafted, and finally, a layer of semiconductor material is deposited onto the receptor molecule layer. The invention can be used in the field of detecting and/or quantifying compounds of interest present, in particular, in a gas or in a solution.

Abstract: Polymers and copolymers of polymerizable fluorescent compounds of 7-hydroxycoumarin such as Ethyl-2-methacrylate Umbelliferone-4-acetate are provided. In addition, a sensor comprising this polymer notably for detecting and/or assaying nitrated and organophosphorus compounds, explosives, and toxic compounds is provided.

Abstract: A method that uses an (DOPC) surfactant based biofilm that reacts with a material in a known manner, and a device that utilizes such a biofilm, to detect a material of interest is provided. The principles of the present invention are particularly useful in detecting/measuring a material that is harmful to a human or to property.

Abstract: The invention relates to a method for assaying inositol hexaphosphate (IHP) in a product that can be injected in humans or animals or in a fraction of this product, in which a metal compound is added to a sample or a fraction of this product and the complexation of said metal compound with the IHP present is subsequently detected, by virtue of which the IHP present in the product or fraction thereof is assayed. The invention makes it possible to assay the IHP in a suspension or a solution, and in particular in the various compartments of a suspension of red blood cells.

Abstract: Compositions for detection of chemical warfare agents that comprise oximate anion reactive sites and fluorophore cores. Methods for detecting a chemical warfare agents that comprise providing a detector molecule comprising an oximate anion reactive site and a fluorophore core and detecting fluorescence from the detector molecule. Methods for enhancing the reactivity of an oximate nucleophile that comprise introducing an oxime into an aprotic solvent and deprotonating the oxime to form the oximate nucleophile with a base that creates noncoordinating anions.