Abstract: Compositions are disclosed which include a CAQK peptide linked or conjugated to a cargo composition, where the peptide selectively homes the composition to a site of nervous system injury in a subject.

Abstract: The present disclosure is directed to a sensing agent. The sensing agent comprises a quantum dot; and a dye moiety coupled to the quantum dot. The sensing agent is capable of sensing at least one analyte chosen from hydrogen sulfide (H2S) and bisulfide. Sensors made from the sensing agents are also disclosed.

Abstract: A method of demonstrating efficacy of a malodor counteractant product, the method comprising the steps of: a) treating one of two odorous fabric articles with a malodor counteractant product, wherein the two odorous fabric articles comprise a malodor compound and are treated with a color indicator wherein the color indicator is configured to change color upon interaction with a malodor compound; b) providing the treated one of the two odorous fabric articles in a first enclosed environment comprising one of two odorless fabric articles, wherein the two odorless fabric articles are treated with the color indicator; c) providing the other one of the two odorous fabric articles in a second enclosed environment comprising the other one of two odorless fabric articles; and d) allow the odorous and odorless fabric articles to remain in the first and second enclosed environments for a period of time sufficient to cause a difference of color between the one of two odorless fabric articles in the first enclosed env

Abstract: An in-liquid state of a mobile device is detected by processing color components indicative of an intensity of the ambient light at different wavelengths and a pressure data indicative of ambient pressure. A first plausibility index indicates a likelihood of an air/liquid transition as a function of variations of at least two color components. A second plausibility index indicates a likelihood of an air/liquid transition as a function of variations of said ambient pressure. If both the first and the second plausibility indices indicate a likely air/liquid transition event, an in-liquid state signal is generated.

Abstract: A method for the in-instrument recombination of volatiles using a gas chromatograph with mass spectrometry and olfactometry detection is described. Compounds that are introduced into the modified GC are separated conventionally on an analytical capillary GC column. The elution profile of volatiles can be segmented, analyzed and arbitrarily combined. In-line with the GC column, a pneumatic flow switch and splitter are connected to a detector and olfactometer. A cold trap allows the user to build a mixture of separated volatiles that is held until the cryotrap is rapidly heated, releasing the mixture for a subject to smell at the olfactory port and to evaluate. The instrument allows for characterization of the aroma quality of specific fractions of aroma volatiles obtained from foods, flowers or beverages without the need for pure chemical standards or the calculation of individual compound concentrations or sensory thresholds.

Abstract: Selective chemosensing agents for hydrogen sulfide are provided. The chemosensing agents can act fast under mild conditions, are chemically stable for long-term storage, are sensitive for detection under near physiological conditions, show a linear concentration-signal relationship within physiologically relevant hydrogen sulfide concentration ranges for easy quantitation, show minimal or no interference by other anions in the blood, and are functional in aqueous solutions and blood plasma.

Abstract: The subject of the invention is a method for determining the H2S content arising during the warm storage of sulfur-containing crude and residual oils and mineral distillates containing sulfur-containing crude and/or residual oils, in which a sample of the sulfur-containing mineral oil is dissolved in a solvent or solvent mixture that boils at more than 200° C. and a carrier gas is caused to flow through the solution of the sulfur-containing mineral oil at temperatures above 80° C., and the quantity of hydrogen sulfide carried out with the carrier gas is analyzed quantitatively.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analyzed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.

Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using 9-oxo-HODE as biomarker.

Abstract: A method comprising (a) obtaining one or more biological samples from a subject wherein the subject has undergone an organ transplant; (b) determining the amount and type of one or more volatile organic compounds in the biological sample; and (c) correlating the amount of volatile organic compounds to a degree of transplant rejection. A device comprising a plurality of sensors configured to detect a plurality of volatile organic compounds in a biological sample of a subject having undergone an organ transplant.

Abstract: Disclosed are dithio compounds that include a quenched fluorophore and a non-fluorophore peptide linked via a dithio bond to the fluorophore. The dithio compounds may be used in methods for detecting thiol-containing compounds or dithio-containing compounds. The dithio compounds also may be used as cellular probes where the peptide portion of the compounds targets the compounds to a specific cellular location.

Abstract: A portable electronic device comprises a chemical sensor that is sensitive to a concentration of a chemical analyte and at least two auxiliary sensors that are sensitive to parameters that are different from the concentration of the chemical analyte. The portable electronic device comprises a control device that receives signals from the chemical sensor and from the auxiliary sensors at a plurality of points in time distributed over a measurement period and correlates the time dependencies of these signals to obtain a corrected reading of the first chemical sensor. The portable electronic device may be employed for breath analysis.

Abstract: Reaction-based fluorscent probes are provided which detect, for example, biologically important sulfane sulfur species (persulfide, polysulfide, and elemental sulfur) in, for example, complex and living systems. The probes are high in selectivity and sensitivity to sulfane sulfurs. Moreover, probes are suitable for bioimaging sulfane sulfurs in living cells.

Abstract: The invention provides methods for isolating a target molecule from a sample. In an embodiment, the method involves contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation, under conditions wherein the agent is capable of binding a target molecule to form a target molecule-capture agent complex, wherein the target molecule is selected from the group consisting of a phosphorylated molecule, a nitrotyrosine-containing molecule and a sulfated molecule, and separating the target molecule-capture agent complex from the sample, thereby isolating the target molecule from the sample. Also provided are methods for determining the presence of a target molecule in a sample, that involve contacting a sample with a capture agent, the agent comprising a siderophore and a transition metal cation.

Abstract: The present invention includes a sensing device and method detecting the presence of a chemical analyte, comprising: a surface; a continuous or discontinuous terbium(III)-triphenylphosphine oxide coordination polymer layer deposited on the surface, wherein the polymer layer is porous; and a luminescence detector, wherein one or more analytes that interact with the polymer layer luminesce at distinct wavelengths unique to each analyte.

Abstract: The present invention provides compounds of Formula I: wherein: R1 is a label (e.g., a detectable group and an anti-tumor agent); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. The compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells. Adduct formation can be detected using analytical methods such as electrospray ionization mass spectrometry and fluorescence.

Abstract: Field-effect transistors include at least two thin layers of a semiconductor material and of an electrically conductive gate material that are rolled up together. These two layers are arranged separated from one another by one or multiple barrier layers and this rolled-up multi-layer structure is integratable as field-effect transistors in circuits and/or in microfluid systems as sensors for the detection of fluids.

Abstract: The invention relates to a method and to a device for sulfur characterization and quantification in a sample of sedimentary rocks or of petroleum products wherein the following stages are carried out: heating said sample in a pyrolysis oven (1) in a non-oxidizing atmosphere, oxidizing part of the pyrolysis effluents and continuously measuring the amount of SO2 generated by said part after oxidation, then transferring the pyrolysis residue of said sample into an oxidation oven (1?) and continuously measuring the amount of SO2 contained in the effluents resulting from said oxidation heating.

Abstract: Technologies are generally described for gas filtration and detection devices. Example devices may include a graphene membrane and a sensing device. The graphene membrane may be perforated with a plurality of discrete pores having a size-selective to enable one or more molecules to pass through the pores. A sensing device may be attached to a supporting permeable substrate and coupled with the graphene membrane. A fluid mixture including two or more molecules may be exposed to the graphene membrane. Molecules having a smaller diameter than the discrete pores may be directed through the graphene pores, and may be detected by the sensing device. Molecules having a larger size than the discrete pores may be prevented from crossing the graphene membrane. The sensing device may be configured to identify a presence of a selected molecule within the mixture without interference from contaminating factors.

Abstract: The present invention relates to a method of improving detection sensitivity of an ion mobility spectrometer, comprising: inserting a sample into a sample receiving device of the ion mobility spectrometer; triggering an operation of spectra acquisition through an optocoupler; when the number of the acquired spectra reaches the level required to contain enough information for accurate detection of explosives with relatively high vapor pressure, adding a dopant instantly to the ionization region by controlling the ON/OFF-state of an electromagnetic valve; when the number of the acquired spectra reaches the level required to contain enough information for accurate detection of explosives with relatively low vapor pressure, stopping the acquisition operation, and turning off the electromagnetic valve so as to stop adding the dopant to the ionization region; analyzing all of the acquired spectra to obtain the detection result.

Abstract: A sulfur breakthrough monitoring assembly for use in a fuel utilization system for detecting sulfur-containing compounds in desulfurized fuel, said monitoring assembly comprising: a heater for heating desulfurized fuel to a predetermined temperature, the predetermined temperature being between 450° C. and 600° C., a sulfur breakthrough detector adapted to receive heated fuel from the heater and including at least a reforming catalyst bed for reforming the heated fuel and a plurality of temperature sensors including a first temperature sensor for sensing temperature of the heated fuel before the fuel is conveyed through the reforming catalyst bed and a second temperature sensor for sensing temperature in the reforming catalyst bed, and a controller for determining whether concentration of the sulfur-containing compounds in the fuel exceeds a first predetermined concentration based on temperature outputs from the first and second temperature sensors.

Abstract: The present invention relates to a method tor enriching and/or separating and/or immobilizing an analyte of interest comprising bringing an analyte of interest into contact with a derivatizing agent; incubating said analyte with said derivatizing agent, thereby incorporating a sulphonic acid group or as analogue thereof into the molecular structure of mo analyte of interest; bringing the analyte of interest into contact with a molecularly imprinted polymer with selective affinity foe a sulphonic acid group or an analogue thereof; and enriching and/or separating and/or immobilizing the analyte of interest by nee of the molecularly imprinted polymer. Further disclosed is a kit comprising a derivatizing agent, which contains a sulphonic group or an analogue thereof and a reactive group for creating a covalent bond between said derivatizing agent nod an analyte of interest, and a molecularly imprinted polymer with selective affinity for a sulphonic acid group or an analogue thereof.

Abstract: It is a subject of the present invention to provide a novel polymer; a filler for measuring a perfluoro compound having an acidic group at terminal which comprises said polymer; a column filled with said filler; and a measuring method for a perfluoro compound having an acidic group at terminal by using said column; as well as a filler for measuring a drug comprising the above-described polymer; a column filled with said filler; and a measuring method for a drug by using said column.

Abstract: The invention relates to a device (10) for detection of harmful substances with a measurement unit (28) for measuring at least one harmful substance and an evaluation unit (30) for determining the concentration of the at least one harmful substance. The invention also relates to a method for detecting harmful substances in a gas mixture. It is hereby provided that the gas mixture is tested for a gaseous harmful substance or simultaneously for several gaseous harmful substances, wherein the gaseous harmful substance or the gaseous harmful substances is/are measured with different sensor means, and the gaseous harmful substances are optionally chemically modified such that a measurement is performed with the existing sensor means.

Abstract: The invention relates to a method for sampling a sulphur-containing solid product including supplying a gas flow comprising hydrogen sulphide, bringing the gas flow into contact with a solid reagent and reacting the solid reagent with the hydrogen sulphide contained in the gas flow, the reaction fixing the sulphur of the hydrogen sulphide by forming a sulphur-containing solid product which is different in color from the solid reagent, and recovering the sulphur-containing solid product. The invention also relates to a device suitable for the implementation of this method.

Abstract: The present invention provides a method of synthesizing compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agents); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.

Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.

Abstract: Provided is a diagnosis method for an oil-filled electrical apparatus, which is for evaluating the degree of danger of copper sulfide being generated within the oil-filled electrical apparatus, comprising: a first step for detecting a specific compound contained within insulating oil inside the oil-filled electrical apparatus; a second step for evaluating the possibility of copper sulfide being generated inside the oil-filled electrical apparatus, on the basis of the result detected by the first step; and a third step for diagnosing the degree of danger of a malfunction occurring in the oil-filled electrical apparatus, on the basis of the evaluation result obtained in the second step. The specific compound contains dibenzyl disulfide and/or a reaction product of a radical resulting from dibenzyl disulfide, and di-tert-butyl-p-cresol and/or a reaction product of a radical resulting from di-tert-butyl-p-cresol, or, di-tert-butyl-phenol and/or a reaction product of a radical resulting from di-tert-butyl-phenol.

Abstract: A vapochromic gold-copper complex [AuL2(Cu(Y)n)2](X)3 exhibiting luminescence is provided, where L is an N-heterocyclic carbene; Y is a heteroatom-containing ligand; X is an anion, and n is an integer having a value of 1 or 2, and solvates thereof. A reaction of [AuL2(Cu(Y)n)2](X)3 with water vapor or an organic compound vapor, for example, affords a modified complex that yields a change in luminescence color under UV excitation. These tricationic vapochromic materials exhibit large changes in the emission through ligand substitution reactions between the solid complex and vapors, which permit use in luminescent vapochromic sensors.

Abstract: Embodiments of compounds for selectively detecting a thiol are disclosed. In some embodiments, the compounds are bridged viologens, and the compounds are capable of reacting with homocysteine and/or glutathione in a buffered solution to produce a change in the solution's absorbance spectrum and/or emission spectrum. Also disclosed are embodiments of methods and kits for detecting homocysteine and/or glutathione with the disclosed bridged viologens.

Abstract: Articles of manufacture and methods of making and using same concern a container having an internal space and a passivated internal metal surface. The container contains a composition of an acid gas and a balance gas contained within the internal space and in contact with the passivated internal metal surface. The stability of the acid gas concentration over time is enhanced.

Abstract: Provided herein are a luminogen compound of formula (I) including a AIE luminophore moiety conjugated with a maleimide moiety and a use of the same for detecting thiol groups in biomolecules. Also provided is a dye molecule, a biosensor or a bioprobe comprising the luminogen compound of formula (I) in use for detecting thiol groups in biomolecules. The detection method of the present subject matter not only has high thio-selectivity and sensitivity, but also is rapid, convenient and handy.

Abstract: A method allowing an accurate diagnosis of a failure of an oil-filled electrical apparatus resulting from production of copper sulfide even with a small amount of an insulating oil is implemented. A diagnostic method for an oil-filled electrical apparatus for diagnosing a failure of the oil-filled electrical apparatus having a copper part disposed in an insulating oil is implemented by detecting at least one compound of bibenzyl and dibenzyl sulfide in the oil of the oil-filled electrical apparatus, to diagnose a failure of the oil-filled electrical apparatus in accordance with the detected amount of the compound. It is configured such that a failure of the oil-filled electrical apparatus resulting from production of copper sulfide can be diagnosed by detecting a specified substance, which allows an accurate diagnosis of a failure even with a small amount of the insulating oil.

Abstract: A method that uses an (DOPC) surfactant based biofilm that reacts with a material in a known manner, and a device that utilizes such a biofilm, to detect a material of interest is provided. The principles of the present invention are particularly useful in detecting/measuring a material that is harmful to a human or to property.

Abstract: The present invention relates to the field of detection of components in gas phase, and in particular to detection of nitric oxide exhaled as a component of breath, using a liquid crystal assay format and a device utilizing liquid crystals as part of a reporting system.

Abstract: Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock.

Abstract: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.

Abstract: A method for assaying anionic detergents in seawater comprises: (1) flow a sample through a sample system and an analysis-detection system; flow a reference solution through a reference system, a valve, and the analysis-detection system; where the sample and reference are mixed; and flow the mixture into an optical cell to produce a baseline, (2) flow a sample through the sample system and analysis-detection system; flow a buffer through a buffer system and a color developing system; where the buffer and a color developer are mixed; and flow the resulting mixture through the valve and analysis-detection system; where the sample is mixed with the buffer and developer mixture; and flow the resulting mixture into the cell to produce the sample spectrogram, (3) repeat (1) and (2) with standards of known detergent concentrations for corresponding spectrograms, and (4) compare the sample spectrogram with the standard spectrograms to determine the sample detergent content.

Abstract: This unique process is a feed forward control of hydroprocessing by on-line sulfur speciation. An on-line gas analyzer such as (GC) with a sulfur specific detector (AED) would be installed to analyze the feed to a hydrotreating unit. The analyzer would be calibrated to quantify the individual sulfur compounds or classes of sulfur compounds present in the feed. The output from the analyzer would be linked to the unit's distributed control system to automatically change temperatures and feed rates to change hydrotreating severity. This invention could bring economical benefits by increasing the life of the hydrotreating catalyst, reducing operating cost, and decreasing the potential amount of offspec product. In one embodiment, the hydrotreating is a hydrodesulphurization process.

Abstract: Articles and methods for the detection and/or quantification of organic analytes are described. The invention provides a chemical indicator test strip, comprising: a substrate; and a coating comprising a leuco dye complex on the substrate, the coating being insoluble in water and reactive with an organic analyte, the coating derived from a solution of leuco dye and developing agent. In another aspect, the coating further comprises adjuvant, in the form of a water-insoluble, polar, hydrophobic, aprotic material that extends the lower limit of detection for the analyte. In still another aspect, the present invention provides a method of using a chemical indicator test strip, comprising: (a) exposing the chemical indicator test strip to a sample comprising an organic analyte; (b) measuring a color change on the chemical indicator test strip following the exposing step; and (c) correlating the color change with the concentration of the analyte in the sample.

Abstract: The invention relates to a device (10) for detection of harmful substances with a measurement unit (28) for measuring at least one harmful substance and an evaluation unit (30) for determining the concentration of the at least one harmful substance. The invention also relates to a method for detecting harmful substances in a gas mixture. It is hereby provided that the gas mixture is tested for a gaseous harmful substance or simultaneously for several gaseous harmful substances, wherein the gaseous harmful substance or the gaseous harmful substances is/are measured with different sensor means, and the gaseous harmful substances are optionally chemically modified such that a measurement is performed with the existing sensor means.

Abstract: Methods and related apparatuses and mixtures are described for detecting hydrogen sulfide in a formation fluid downhole. A detection mixture is combined with the formation fluid downhole. The detection mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and charged nanoparticles sized so as to inhibit significant aggregation of the metal sulfide so as to enable spectroscopic detection of the metal sulfide downhole. The combined mixture and formation fluid is then spectroscopically interrogated so as to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the formation fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.

Abstract: The present invention provides a method for analyzing gases such as carbon dioxide, and includes passing a gas stream containing impurities into a gas adsorption means for a length of time at ambient or higher temperatures to adsorb the impurities therein, stopping the flow of the gas stream, and desorbing and analyzing the impurities using a detector.

Abstract: A method of assessing body odor using as an index an indicator material comprising an alcohol compound having a mercapto group at the 3-position represented by the following formula (2) and/or a substance that is a derivative of an alcohol compound having a mercapto group at the 3-position, wherein an atom(s) or an atom group(s) is introduced to a mercapto group and/or a hydroxyl group of an alcohol compound having a mercapto group at the 3-position represented by the formula (2):

Abstract: A method for detecting the onset of ovulation in a female mammal is provided. The method includes contacting mouth air of the female mammal with an arylmethane test chromogen in an amount effective to undergo a rapid and detectable color change in the presence of one or more volatile sulfur compounds. The color of the test chromogen is compared to a control color that corresponds to a pre-ovulatory sulfur content. The difference in color between the test chromogen and the control color is correlated to the onset of ovulation.

Abstract: A method for preparing an analysis sample which involves the sugar chain capture step comprising a reaction of capturing a sugar chain and/or a sugar derivative from a biological sample by using a sugar chain capture agent and the excision step comprising excising a compound containing a moiety capturing the sugar chain and/or the sugar derivative from the sugar chain capture agent after the completion of the sugar chain capture reaction and releasing the compound.

Abstract: Provided herein are methods of decreasing a level of kynurenic acid in a cell and of treating a pathophysiological condition in a subject associated with an increase in kynurenic acid in a subject. In these methods the inhibitory action of dicarboxylic acids or derivatives or analogs thereof are effective to inhibit activity of kynurenine aminotransferase II. Also provided is a method of screening for potential inhibitory compounds for kynurenine aminotransferase II. The dicarboxylic acids or derivatives or analogs thereof may have the structural formula, where R1 is H, NH2 or NHCH3, R2 is H or CH3, n is 0 to 14, and X is —COOH, CH2OH, —PO3H2, —SO3H, or —SO3H; or a pharmacologically acceptable salt.

Abstract: A portable electronic device includes at least one function module selected from a group consisting of a wireless communication module, an image capturing module, an audio/video file player module, and an internet module, a halitosis measuring module, and a processor connected to the function module and the halitosis measuring module. The processor controls the function module to work, and detects a level of volatile sulfur compounds (VSCs) in a person's mouth using the halitosis measuring module.

Abstract: It is an object of the present invention to provide: a novel thiol-detecting reagent, which can be used in vivo and which solves the problem regarding the generation of background fluorescence due to hydrolysis; and a method for detecting thiol using the aforementioned reagent. The present invention provides a compound represented by the following formula (1): wherein each R2 independently represents an alkyl group containing 1 to 6 carbon atoms, a halogen atom, or a hydrogen atom.