Including Chromatography Patents (Class 436/161)
  • Patent number: 11170895
    Abstract: An olfactory-based cognitive system is implemented by receiving a request from a user, the request including one or more attributes, wherein the one or more attributes include at least olfactory-sensed data and an identification of the olfactometer or electronic nose utilized to gather the olfactory-sensed data. A set of candidate recommendations is generated utilizing the one or more attributes from data sources. A confidence score is generated for each candidate recommendation in the set of candidate recommendations indicating a confidence that the corresponding candidate recommendation is valid to address the request. Each candidate recommendation in the set of candidate recommendations is ranked according to its respective confidence scores. The ranked listing of candidate recommendations is presented to the user for use in addressing the request.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: November 9, 2021
    Assignee: International Business Machines Corporation
    Inventors: Joseph Foti, Jr., Elisabeth R. Stahl, Clarisse T. Taafe-Hedglin
  • Patent number: 11084985
    Abstract: Methods and systems are provided herein utilizing a membrane cascade to separate a hydrocarbon feed into boiling point fractions. Also provided herein are methods for selecting membranes for said cascades to achieve the desired boiling point fraction separation.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: August 10, 2021
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Benjamin A. McCool, Dhaval A. Bhandari, Yogesh V. Joshi
  • Patent number: 11071928
    Abstract: Method of supercritical fluid or liquid chromatography of a product, including the steps of, continuously in this order: an analytical step according to an analytical route; a switching step comprising a route changing operation between the analytical route and a preparative route; if the preparative route is selected in the switching step, a preparative step according to the preparative route.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: July 27, 2021
    Assignee: PIC SOLUTION
    Inventor: Mohamed Shaimi
  • Patent number: 11034639
    Abstract: The present specification discloses methods of purifying one or more cannabinoids from a plant material using unique biphasic solvent systems and liquid-liquid chromatography as centrifugation partitioning chromatography (CPC) or counter current chromatography (CCC). The present specification also provides purified cannabinoids such as CBG, CBGA, CBGV, CBD, CBDA, CBDV, THC, THCA and THCV, compositions comprising one or more of these cannabinoids produced by the disclosed method, and methods for treating a disease or condition employing such purified cannabinoids and compositions.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: June 15, 2021
    Assignee: PHYTOPLANT RESEARCH S.L.
    Inventor: Xavier Nadal Roura
  • Patent number: 10996204
    Abstract: Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: May 4, 2021
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Joseph D. Michienzi, Joshua A. Shreve, Jason F. Hill, Abhijit Tarafder, Michael O. Fogwill, Keith Fadgen
  • Patent number: 10881985
    Abstract: Systems and methods for automatically packing resin into and unpacking resin from a reusable separation column for sample analysis are described. A method embodiment includes, but is not limited to, introducing a slurry of resin to a reusable sample separation column to pack the reusable column with resin; introducing a sample solution to the reusable sample separation column; and unpacking the resin from the reusable sample separation column with a flow of liquid unpacking reagent and gaseous material.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: January 5, 2021
    Assignee: ELEMENTAL SCIENTIFIC, INC.
    Inventor: Michael Paul Field
  • Patent number: 10830780
    Abstract: The disclosure relates to systems, apparatuses, and methods for estimating a terpene level of two or more terpenes of the plurality of terpenes in the sample to generate a set of terpene levels; and/or estimating a cannabinoid level of two or more cannabinoids of the plurality of cannabinoids in the sample to generate a set of cannabinoid levels; configured to store a set of groups and classify the sample to a group of the set of groups, based on said terpene and cannabinoid levels. The present disclosure also relates to systems, apparatuses, and methods configured to generate entourage effect values and organoleptic values, based on said cannabinoid and terpene levels.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: November 10, 2020
    Assignee: Biotech Institute, LLC
    Inventors: Matthew W. Giese, Mark Anthony Lewis
  • Patent number: 10828265
    Abstract: Melts or ionic liquids containing amorphous propranolol, topical formulations and patches for transdermal drug delivery, and methods of making and using thereof are described herein. The melts or ionic liquids may be in a topical drug delivery formulation or patch to be applied to the skin. The drug delivery formulation or patch contains a sufficient amount of the amorphous propranolol to deliver a therapeutically effective amount of the amorphous propranolol to the patient in need of treatment, such as for the treatment or amelioration of infantile hemangioma. The formulations have a low viscosity and reduced skin irritation compared to the crystalline propranolol free base (PFB). The melts or ionic liquids can be formed by a salt metathesis reaction.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: November 10, 2020
    Assignee: The Regents of the University of California
    Inventors: Kazuhiro Aoyagi, Michael Zakrewsky, Samir Mitragotri
  • Patent number: 10799546
    Abstract: The present disclosure relates to scalable processes for extracting, refining and remediating extracts of natural products, such as plant material and for providing well controlled refined extracts.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: October 13, 2020
    Assignee: BIOMASS OIL SEPARATION SOLUTIONS, LLC
    Inventors: Robert Patrick Jansen, Neta Matis, Adam F. Tracy, Lucas A. Burke, Brendon C. Stout
  • Patent number: 10802006
    Abstract: A method for identifying the adulteration of a pine bark extract or a peanut skin extract in a grape seed extract using HPLC fingerprint spectrums. The method includes 1) establishing HPLC fingerprint spectrums of the three extracts; 2) determining characteristic peaks of pine bark extract and peanut skin extract; 3) testing a grape seed extract sample using liquid chromatography detection to identify the adulteration of pine bark extract or peanut skin extract in the sample according to whether the chromatogram contains the characteristic peaks of pine bark extract and/or peanut skin extract, wherein the addition of more than 3% of adulterants can be accurately identified. The method has good stability and reproducibility, high efficiency, obvious identification characteristics, provides a theoretical basis for the identification of the plant sources of grape seed extracts, and is conducive to promoting the healthy development of the plant extract industry.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 13, 2020
    Assignee: Chenguang Biotech Group, Co. Ltd.
    Inventors: Wei Gao, Li Zhou, Qingshan Yang, Lei Wang, Yunhe Lian
  • Patent number: 10782264
    Abstract: Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: September 22, 2020
    Assignee: INTABIO, INC.
    Inventor: Erik Gentalen
  • Patent number: 10697912
    Abstract: Provided are a gas detection method and a gas detector which have a high durability to silicone poisoning and is capable of detecting the type and the concentration of a target gas to be detected with certain accuracy even when the detector is used in an environment where a silicone compound exists. The gas detector employs a contact combustion-type gas sensor which includes two gas detection elements, each intermittently driven, and in which only one gas detection element is supplied with a gas through a silicone removal filter. Acquired in an energization duration of each of the gas detection elements are two or more pieces of output data by the one gas detection element and two or more pieces of output data by the other gas detection element, which constitutes output variation patterns for a test gas.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: June 30, 2020
    Assignee: RIKEN KEIKI CO., LTD.
    Inventors: Yuki Tanaka, Ryuji Asada, Yoshikazu Shibasaki, Shunsuke Takahashi
  • Patent number: 10620171
    Abstract: The present disclosure generally relates to improved methods for separating and analyzing compounds by liquid chromatography, particularly when coupled with mass spectrometry. The methods include the addition of an additive to a mobile phase carrying a sample. The mobile phase additive may be effective for improving peak shapes of targeted analytes in acquired data, and/or eliminating or at least reducing ion suppression. The methods are particularly suited for anionic compounds such as phosphorylated compounds.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: April 14, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Jordy J. Hsiao, Hongfeng Yin, Oscar G. Potter
  • Patent number: 10605803
    Abstract: A composition for enzyme immunoassay using immunofluorescence comprises (i) a fluorogenic enzymatic substrate and (ii) a quenched fluorogenic compound that forms a fluorescent compound after hydrolysis of the fluorogenic enzymatic substrate. The composition may be useful for performing a method for in vitro detection and/or quantification of an analyte of a liquid test sample liable to contain the analyte.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: March 31, 2020
    Assignee: BIOMERIEUX
    Inventors: Aldo Paolicchi, Antonio Sanesi, Veronica Lucia Rossi, Andrea Ienco, Vanessa Susini
  • Patent number: 10577597
    Abstract: In accordance with one embodiment of the present invention, there is disclosed an apparatus for nucleic acid extraction and an operation method thereof. The apparatus for nucleic acid extraction includes: a first rack having a plurality of sample tube receivers arranged in a circle; a second rack having a plurality of elution tube receivers arranged in a circle on an outer side thereof and a washing solution receiver positioned at the center thereof, a part of the washing solution receiver extending outwards to have projections formed in alternation with a plurality of the elution tube receivers; a main body having the first and second racks arranged to position the first rack on the top of the second rack; a rotational driver for separately rotating the first and second racks; a dispenser for separately dispensing a washing solution and an eluting solution into sample tubes; and a pressurizer for maintaining the inside of the sample tubes under raised pressure.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: March 3, 2020
    Assignee: NANOBIOSYS INC.
    Inventors: Sung Woo Kim, Jun Hur, Eun-Sub Kim, Chi-Woo An, Song Gyun Jung, Jae Young Byun, Duck Joong Kim, Mi Ree Kim, Do Hee Kim, Kang Choi, Jin Pyung Kim
  • Patent number: 10568958
    Abstract: The present invention is directed to a composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence, complexed with a complexing agent; b) an antigen, preferably a protein or peptide antigen and/or a nucleic acid sequence encoding said antigen; and c) a carrier molecule for combined packaging the adjuvant component and the antigen. The present invention is also directed to the first medical use of such a composition or vaccine composition and to the second medical use of such a composition or vaccine composition or components thereof for the treatment of diseases, such as infectious or cancer or tumour diseases as defined herein. The present invention furthermore discloses kits comprising such a composition or vaccine composition.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: February 25, 2020
    Assignee: CureVac AG
    Inventors: Patrick Baumhof, Karl-Josef Kallen, Mariola Fotin-Mleczek
  • Patent number: 10466220
    Abstract: Techniques for alerting for instruments that transfer physical samples are disclosed. An alarm module, placed within a communication pathway of a first chemical processor and a second chemical processor, includes a timer configured to count time elapsed since receiving, from the first chemical processor, a transfer-ready signal indicating that 1) the first chemical processor received a receive-ready signal from the second chemical processor; ii) the first chemical processor has completed processing a chemical analyte; and iii) the first chemical processor is ready to physically transfer the chemical analyte to the second chemical processor. Upon receiving the transfer-ready signal from the first chemical processor, the timer is restarted. An alarm triggers when the elapsed time counted by the timer exceeds a specified threshold. The alarm is audible or visual. Upon the triggering of an alarm, an alert notification (e.g., an email, a text message, etc.) is transmitted.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: November 5, 2019
    Assignee: Pace Analytical Services, LLC
    Inventors: Joshua R. Brown, Kathleen A. Zenisek, Peter A. Schulert, Forest W. Darling
  • Patent number: 10371675
    Abstract: A two-dimensional chromatogram creator creates a two-dimensional chromatogram based on data obtained for each of two samples. A chromatogram difference calculator creates a two-dimensional differential chromatogram showing the intensity difference between the two two-dimensional chromatograms. A blob detector detects blobs on each chromatogram. A matching-blob extractor compares the blobs located on the differential chromatogram with those located on each of the two other chromatograms, to extract blobs which can be considered to be located at the same temporal position. If there are two blobs extracted at the same temporal position on the two chromatograms, a normalized value of the intensity difference between the two blobs is calculated, and the line type of the boundary line for indicating the extracted blob on the display is chosen according to that value.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: August 6, 2019
    Assignee: SHIMADZU CORPORATION
    Inventor: Megumi Hirooka
  • Patent number: 10247642
    Abstract: A device comprises a contact reaction chamber, a circulating water inlet, a clear water basin, a circulating pump, a circulating water outlet, a solid phase extractant collecting tank, a magnetic holder, an electromagnet, a solid-liquid separation area, a drain valve, a wall sprinkling water inlet, and a wall sprinkling pipe, wherein, the contact reaction chamber is in a conical shape, and utilizes hydraulic power to perform stir to ensure no dead corner exists during contact stir; the obconical solid-liquid separation area increases the action area between a magnetic solid phase extractant and the electromagnet; the solid phase extractant collecting tank is in a downwards protruding dish shape to prevent the solid phase extractant from losing.
    Type: Grant
    Filed: June 10, 2017
    Date of Patent: April 2, 2019
    Assignee: NANJING UNIVERSITY
    Inventors: Qing Zhou, Wei Wang, Aimin Li, Qingqing Zhao, Minglu Wang, Rui Gao, Xiaowen Ma, Peng Shi, Xun Chen
  • Patent number: 10239808
    Abstract: A method is provided for removing THC from raw cannabis oil.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: March 26, 2019
    Assignee: Canopy Holdings, LLC
    Inventors: Jacob Black, Ryan Beigie, Alex Mateo
  • Patent number: 10198630
    Abstract: For a signal waveform to be processed, the continuous wavelet transform is performed with various scale factors, and a wavelet coefficient at each point in time is calculated. On an image showing the strength of the wavelet coefficient with respect to the scale factor and time, ridge lines are detected, and based on these ridge lines, positive and negative peak candidates are extracted, after which an error in the position and width of the peak due to the influence of a neighboring peak is corrected. Subsequently, the degree of non-symmetry of the peak shape or other features are examined to remove false negative peaks due to negative peak artifacts. Subsequently, a true peak cluster, a false peak cluster resulting from the removal of high-frequency components of a high-frequency noise or other causes, and other kinds of peaks are identified, and the obtained result is used to remove false peaks.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: February 5, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Akira Noda, Hiroaki Kozawa
  • Patent number: 10079138
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: September 18, 2018
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: J. Fred Banks, Peter P. Chou, Noriya M. Matt
  • Patent number: 10036757
    Abstract: Systems and assay methods are disclosed for detecting an autoantibody in a sample. In certain instances, the systems and methods employ a mass tag releasably connected to an antigen. The tag is thereafter released for detection. A tag can be detected by mass spectrometry or in certain instances the tag is fluorescent. Methods for diagnosing a disease or disorder in a subject are also disclosed.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 31, 2018
    Assignee: Nestec S.A.
    Inventors: Sharat Singh, Shui Long Wang
  • Patent number: 9824876
    Abstract: Certain embodiments described herein are directed to injector inserts and injector assemblies. In some examples, an injector insert that includes an inlet comprising a substantially inert metal is described. In other examples, an injector that includes a major amount of a substantially inert metal in a fluid flow path is disclosed. Devices and systems using the injectors inserts and injectors are also described.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: November 21, 2017
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Rosario Mannino, William Goodman
  • Patent number: 9783497
    Abstract: The present invention relates to methods of determining the purity of a sample of 3,4-diaminopyridine comprising determining the presence, absence, or amount of a dimer of 3,4-diaminopyridine or a dimer of 3,4-diaminopyridine in the form of a salt, solvate or complex or a combination thereof. The invention also relates to methods of detecting and quantitating degradation in a sample of 3,4-diaminopyridine. Dimers of 3,4-diaminopyridine and methods of making and isolating the same are also provided.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: October 10, 2017
    Assignee: Jacobus Pharmaceuticals, Inc.
    Inventors: Guy Alan Schiehser, Rajendra Shah, Wenyi Zhao
  • Patent number: 9759676
    Abstract: A gas sensor array containing a gas flow path in which a gas to be analyzed flows, and a plurality of gas sensors set along the gas flowing direction of the gas flow path, wherein the gas sensors each has a constitution wherein semiconductor microcrystals that come into contact with the gas to be analyzed that flows in the above gas flow path are disposed between two electrodes.
    Type: Grant
    Filed: September 2, 2013
    Date of Patent: September 12, 2017
    Assignee: Kake Educational Institution
    Inventor: Norio Akiyama
  • Patent number: 9696284
    Abstract: Described are extraction columns and systems that include extraction columns. The extraction column includes a column body that has a reservoir portion, an extraction media portion, and a collar portion. The reservoir portion includes an inlet and a reservoir. The extraction media portion includes an elongated sleeve having an inner surface defining a cavity. The extraction media portion has an inlet end in fluid communication with the reservoir and an outlet end. An extraction medium is disposed in the cavity of the elongated sleeve. The collar portion extends axially in a common direction with the elongated sleeve. The collar portion has a terminal end which is spaced apart from the outlet end of the elongated sleeve and which extends axially at least to a plane defined by the outlet end of the elongated sleeve.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: July 4, 2017
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Joni Rannisto, Kelly Flook, Leena Valmu, Ville Saarainen, Suvi Ravela, Johan Finell
  • Patent number: 9685311
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: June 20, 2017
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: J. Fred Banks, Peter P. Chou, Noriya M. Matt
  • Patent number: 9587242
    Abstract: Described are compositions and methods relating to variant filamentous fungi having altered growth characteristics. Such variants are well-suited for growth in submerged cultures, e.g., for the large-scale production of enzymes and other proteins for commercial applications.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: March 7, 2017
    Assignee: DANISCO US INC.
    Inventors: Elizabeth A. Bodie, Robert James Pratt, II
  • Patent number: 9493538
    Abstract: The present invention provides a snare molecules comprising an attachment moiety (which facilitates attachment of a receptor to a cell) and a receptor for a toxic pathogenic or infectious agent, e.g., a virus. Methods of producing such snare molecules and their therapeutic and/or prophylactic uses are also provided by the present invention.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: November 15, 2016
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Robert W. Finberg, Damon R. Asher
  • Patent number: 9442889
    Abstract: An apparatus comprises a decoder and an actuator. The decoder is configured to receive a signal comprising a target olfactory pleasantness, to determine one or more combinations of odors which produce the target olfactory pleasantness, and to select a given one of the combinations of odors. The actuator is coupled to the decoder and configured to utilize the given combination of odors to produce an odor with the target olfactory pleasantness.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: September 13, 2016
    Assignee: International Business Machines Corporation
    Inventors: Yi-Min Chee, Angela Schoergendorfer, Lav R. Varshney
  • Patent number: 9417196
    Abstract: A method of centering a single crystal sample in the X-ray beam of a diffractometer uses detection of diffraction spots with an active pixel sensor operated in rolling shutter mode. A sample is mounted in the automated goniometer head of the diffractometer and an approximate center of the sample found through which three perpendicular sample axes pass. With a first sample axis perpendicular to a center axis of the X-ray beam, the sample is moved along the first axis from a first position outside of the beam, through the beam and then to a second position outside of the beam. The positions at which first the presence and then the absence of diffraction spots are detected are determined, and the steps repeated for each of the other two perpendicular directions. A precise center may then be found by determining the centroid of the six coordinates thereby obtained.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: August 16, 2016
    Inventor: Joerg Kaercher
  • Patent number: 9400766
    Abstract: An apparatus comprises a decoder and an actuator. The decoder is configured to receive a signal comprising a target olfactory pleasantness, to determine one or more combinations of odors which produce the target olfactory pleasantness, and to select a given one of the combinations of odors. The actuator is coupled to the decoder and configured to utilize the given combination of odors to produce an odor with the target olfactory pleasantness.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: July 26, 2016
    Assignee: International Business Machines Corporation
    Inventors: Yi-Min Chee, Angela Schoergendorfer, Lav R. Varshney
  • Patent number: 9327269
    Abstract: A stationary phase that increases the number of column stages and that exhibits an excellent molecular discrimination ability is realized by a stationary phase that contains a polymer having, in main chain repeat units, an aromatic ring that forms a portion of the main chain and a bipolar atomic group that forms a portion of the main chain, wherein the stationary phase has a specific surface area of 5 to 1000 m2/g.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: May 3, 2016
    Assignee: DAICEL CORPORATION
    Inventors: Toru Shibata, Satoshi Shinkura
  • Patent number: 9322811
    Abstract: A fluidic connection system may comprise a port which includes a capillary tube receptacle with an end seal face and a threaded wall. The fluidic connection system may also comprise a capillary tube that includes a front end face for sealingly abutting against the end seal face of the port. On the capillary tube, a flange may be affixed at a distance from the front end face of the capillary tube. The fluidic connection system may further comprise a fitting nut that includes an axial hole to allow the capillary tube to pass therethrough and a matching threaded wall corresponding to the threaded wall of the port. The fitting nut may be slidably coupled with the capillary tube behind the flange. The distance at which the flange is affixed may be predetermined such that when the flange is pushed forward by the fitting nut, the front end face of the capillary tube abuts directly against the end seal face of the port.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: April 26, 2016
    Assignee: DIONEX CORPORATION
    Inventors: Michael John McAdams, Milton Liu, George N. Proper
  • Patent number: 9283541
    Abstract: In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to acidified water vapor or immersion in a concentrated acid bath (e.g., HCl and methanol). At least a portion of the elongated nanostructures may be removed after being coated. Embodiments for TLC plates and related methods are also disclosed.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: March 15, 2016
    Assignee: BRIGHAM YOUNG UNIVERSITY
    Inventors: Matthew R. Linford, Robert C. Davis, Richard R. Vanfleet, David Scott Jensen, Li Yang, Jun Song
  • Patent number: 9196923
    Abstract: The present invention provides an electrolyte solution including an ionic liquid having the structure of formula (I): wherein R1 is C1-C6alkyl, R2 is C2-C7alkyl, A? is defined in the specification. The electrolyte solution of the present invention has high conductivity and high thermal stability.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: November 24, 2015
    Inventors: Hao-Hsun Chang, Fu-Ming Wang, Jung-Jung Liu
  • Patent number: 9097632
    Abstract: In a device (1) for rapid pressure-freezing an aqueous sample (3), such as a biological specimen, a pressurized cooling medium can be fed into a high-pressure chamber (11) into which a sample holder (30) containing a sample (3) is inserted and which is sealed with a pressure-tight seal, to the location of the sample holder (30) held therein. The high-pressure chamber (11) comprises a viewing window structure (2) with a pressure-tight window (20), through which light can be directed from the outside onto the sample (3) located in the sample holder (30). The window (20) can comprise a transparent window element made of a high-pressure-resistant material, wherein the window element (20) is held by a pressure- and temperature-resistant window bearing provided in the high-pressure chamber.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: August 4, 2015
    Assignee: LEICA MIKROSYSTEME GMBH
    Inventors: Reinhard Lihl, Rainer Wogritsch, Heinz Plank
  • Patent number: 9086424
    Abstract: Described is a method of transferring a chromatographic method between liquid chromatography (LC) systems. The method is based on a determination of an isoretention temperature at which two solutes co-elute. The method enables separations to be performed using different LC systems with reproducible and equivalent results. For example, the method allows for a chromatography method developed for HPLC to be more readily transferred to a UPLC system and for a chromatography method developed for a UPLC system to be more readily transferred to a HPLC system. The method addresses LC systems having column ovens of different design in which the internal column temperatures are not equal although the operating temperatures of the column ovens may be accurately controlled to equal values. The retention behavior and resolution of different LC systems is caused to be substantially the same so that equivalent separation results are obtained.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: July 21, 2015
    Assignee: Waters Technologies Corporation
    Inventors: Richard W. Andrews, Peyton C. Beals
  • Publication number: 20150140593
    Abstract: A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (LC-MS) methods, more especially for LC-MS methods employing electrospray (ESI) or atmospheric pressure chemical ionization (APCI) ionization systems.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Inventor: Michael Arthur Quilliam
  • Patent number: 9029162
    Abstract: Disclosed are methods and systems for the analysis of testosterone in a sample using supported liquid extraction and liquid chromatography-mass spectrometry.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: May 12, 2015
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Russell Philip Grant, Matthew Crawford, Donald Walt Chandler, William Curtin
  • Patent number: 9029166
    Abstract: The present invention relates to a method of identifying a natural substance that is capable of complexation with Ni2+, Cu2+ and/or Fe2+ ions, wherein an extract containing natural substances is led over a stationary phase loaded with Ni2+, Cu2+ and/or Fe2+ ions, which is suitable for immobilized metal affinity chromatography (IMAC).
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: May 12, 2015
    Assignee: Symrise AG
    Inventors: Andreas Degenhardt, Gerhard Krammer, Nicole Schulze
  • Publication number: 20150111305
    Abstract: An electrolytic device comprising: a central sample flow channel, first and second regenerant flow channels, first and second charged barriers disposed between said sample flow channel and first and second regenerant flow channels, and pairs of oppositely charged, spaced electrodes disposed in the regenerant flow channels. Also, electrolytic devices with a different electrode configuration are described. Also, methods of using the devices, e.g., for suppression in an ion chromatography system are described.
    Type: Application
    Filed: October 18, 2013
    Publication date: April 23, 2015
    Applicant: DIONEX CORPORATION
    Inventors: Kannan SRINIVASAN, Sheetal BHARDWAJ, Rong LIN
  • Patent number: 9012206
    Abstract: The invention provides methods of performing a sizing analysis. In the methods, a sizing ladder used in performing the sizing analysis is corrected. In one method, the sizing ladder is corrected for batch-to-batch variations in a sieving gel. In another method, the sizing ladder is corrected for a sample concentration that is different from the archival sizing ladder concentration. Methods are also provided in which the sizing ladder is corrected using a standard marker in a sample and/or using a real-time standard sizing ladder. The methods may be used individually or in combination.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: April 21, 2015
    Assignee: Caliper Life Sciences, Inc.
    Inventors: Dan Camporese, Advit Bhatt, Josh Molho, Hui Xu, Ken Summers
  • Patent number: 9005990
    Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 14, 2015
    Assignee: Xellia Pharmaceuticals APS
    Inventors: Torben Koch, Carsten Overblle Petersen
  • Patent number: 9005526
    Abstract: A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 ?m. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems are capable of detecting the component parts of complex proteomic samples down to the low attomole to sub-attomole level.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: April 14, 2015
    Assignee: Northeastern University
    Inventors: Barry L. Karger, Jian Zhang
  • Patent number: 9005926
    Abstract: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: April 14, 2015
    Assignee: Biogen Idec Ma Inc.
    Inventors: David Evans, R. Blake Pepinsky, Dingyi Wen, Rashmi Rohit Kshirsagar, Karin Lucas
  • Patent number: 8999719
    Abstract: The present invention relates to a quality control marker and method of using such marker in qualitative and quantitative authentication of Dendrobium officinale Kimura et Migo, which is known as a Chinese medicine under the name of Tiepi Shihu ().
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: April 7, 2015
    Assignee: Hong Kong Baptist University
    Inventors: Quanbin Han, Hubiao Chen, Jun Xu
  • Patent number: 8993333
    Abstract: Disclosed is a method of providing a risk evaluation and diagnosis of human cancer, by examining the presence, in the volatile fraction of a human saliva sample, of a combination of particulate biochemical volatile organic compounds, which is indicative of an increased risk of developing cancer.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: March 31, 2015
    Assignee: Institut Clinident
    Inventor: Franck Chaubron
  • Publication number: 20150079692
    Abstract: A method for determining the concentration of a phenoxy herbicide in an aqueous sample, by simultaneously phase-transfer catalyst extracting and alkylating an aqueous sample comprising a phenoxy herbicide to form a sample composition, and measuring an amount of the alkylated phenoxy herbicide in the sample composition. The method includes controlling factors such as pH of the aqueous matrix, temperature, extraction duration, type and amount of derivation reagents, and type and amount of phase transfer catalyst.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 19, 2015
    Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: Abdulmumin A NUHU, Chanbasha Basheer, Khalid Alhooshani, Abdul Rahman Al-Arfaj