Thyroid Hormone Tests (e.g., T3, T4, Tbg, Tsh, Etc.) Patents (Class 436/500)
  • Patent number: 10530423
    Abstract: Aspects of the subject disclosure may include, for example, a device that facilitates transmitting electromagnetic waves along a surface of a physical transmission medium without requiring an electrical return path that facilitates delivery of electric energy to devices, and sensing a condition that is adverse to the electromagnetic waves propagating along the surface of the physical transmission medium. Other embodiments are disclosed.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: January 7, 2020
    Assignee: AT&T Intellectual Property I, L.P.
    Inventors: Mitchell Harvey Fuchs, Irwin Gerszberg
  • Patent number: 10514330
    Abstract: The present invention refers to a device, comprising a hollow body having at least one open end comprising at least one solid matrix binding, adsorbing, absorbing, chelating or retaining compounds which are not desired in a sample and preferably at least one barrier which is non-permeable for liquids and solids under ambience conditions, however, becomes liquid-permeable by applying an external force to the barrier, the use of such a device for isolating or purifying a biomolecule from a sample, a method for preparation of the device and a method for isolation or purification of any biomolecule using said device.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: December 24, 2019
    Assignee: QIAGEN GmbH
    Inventors: Vera Holländer, Markus Müller, Karin Schulte
  • Patent number: 10435563
    Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, L1, L2, L3, L4, L5, L6, M1, M2, A, q, w and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: October 8, 2019
    Assignees: Sony Corporation, Sony Corporation of America
    Inventors: Tracy Matray, Hesham Sherif, C. Frederick Battrell
  • Patent number: 10203338
    Abstract: Methods and reagents are disclosed for preparing a liquid solution of a receptor. The methods comprise combining in a liquid medium the receptor, a chelating agent and a C2-C6 polyol. An amount of the chelating agent and the C2-C6 polyol is sufficient to achieve a stable and active receptor in the liquid solution, which is maintained at a temperature of about 2° C. to about 40° C. The compositions may be employed in assays for the determination of analytes that include receptor-binding analytes.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: February 12, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: David Kiaei
  • Patent number: 10191038
    Abstract: In a known method of measuring a target substance, comprising: providing a sample solution containing the target substance, a first reaction solution, and a second reaction solution; sequentially aspirating the sample solution and the first reaction solution, using a measuring apparatus equipped with a dispensing unit, into the dispensing unit; discharging them at a time from the dispensing unit, to bring them into contact with the second reaction solution, and to form a complex of the target substance and a first partner which is contained in at least one of the first reaction solution or the second reaction solution and reacts specifically with the target substance; and analyzing the resulting complex, an improved method capable of inhibiting a reaction which adversely affects measurement results is provided.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: January 29, 2019
    Assignee: LSI MEDIENCE CORPORATION
    Inventors: Keiichi Shoji, Hiroyuki Yokoi
  • Patent number: 10048273
    Abstract: Methods and reagents are disclosed for preparing a liquid solution of a receptor. The methods comprise combining in a liquid medium the receptor, a chelating agent and a C2-C6 polyol. An amount of the chelating agent and the C2-C6 polyol is sufficient to achieve a stable and active receptor in the liquid solution, which is maintained at a temperature of about 2° C. to about 40° C. The compositions may be employed in assays for the determination of analytes that include receptor-binding analytes.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: August 14, 2018
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS, INC.
    Inventor: David Kiaei
  • Patent number: 9493656
    Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: November 15, 2016
    Assignee: Life Technologies Corporation
    Inventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson
  • Patent number: 9476891
    Abstract: The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and insulin analogs.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: October 25, 2016
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Junichi Kondou, Tomo Shimizu, Mitsuaki Yamamoto, Yasushi Nakamura
  • Patent number: 9341620
    Abstract: A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: May 17, 2016
    Assignee: Multi-Sense Technologies Limited
    Inventors: Phillip Lowe, Steven Alexander Keatch, Brian McGuigan
  • Patent number: 9138747
    Abstract: A specimen collection apparatus is provided. The specimen collection apparatus may include a container, a funnel for removable insertion in an opening of the container, a funnel cover; a removable seal, and a dispensing apparatus sealed within the funnel cover in a reagent-specific atmosphere. The dispensing apparatus may include a cap, a reagent housing attached to the cap, and a reagent designed to liquefy a specimen, stabilize the pH of the liquefied specimen, and be compatible with diagnostic procedures.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 22, 2015
    Assignee: Alpha Tec Systems, Inc.
    Inventors: Richard O Williams, Mark R Williams, Christopher O Williams
  • Patent number: 9091639
    Abstract: The invention relates to a method for calibrating and/or adjusting an analytical device for chemical substances. A predetermined concentration of a chemical substance in a reference liquid is measured by mixing the reference liquid with a reagent for producing a color change, followed by irradiating with light of a predetermined wavelength. Based on the absorption of the light by the reference liquid, a concentration is determined, which is compared with the predetermined concentration of the reference liquid. In the case of which a calibrating and/or adjusting associated with the measurement process is possible without long interruptions of the measurement process, the predetermined concentration of the reference liquid is gained by mixing at least two standard, which contain different concentrations of the chemical substance.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: July 28, 2015
    Assignee: Endress + Hauser Conducta Gesellschaft für Mess-und Regeltechnik mbH + Co. KG
    Inventors: Andrea Gross, Ulrich Kathe, Thomas Schipolowski, Ralf Steuerwald
  • Patent number: 8999727
    Abstract: Methods are described for detection of autoimmune antibodies against the TSH receptor using TSH receptor chimeras, which preferably only contain the extracellular portion of the TSH wild type receptor modified as chimera, and are modified by highly immunogenic peptide residues or by enzymes suitable for detection, wherein the determination methods described allow simple detection of stimulating, blocking and neutral autoimmune antibodies.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: April 7, 2015
    Inventor: Ulrich Loos
  • Patent number: 8963077
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: February 24, 2015
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: J. Fred Banks, Peter P. Chou, Noriya M. Matt
  • Publication number: 20150037813
    Abstract: The present invention provides a means and a method for specifically measuring a substance such as a small substance with high sensitivity by a sandwich method. Specifically, the present invention provides an antibody capable of specifically binding to an affinity complex and a method of measuring of the affinity complex comprising measuring the affinity complex using the antibody capable of specifically binding to the affinity complex. The antibody of the present invention may be a full-length antibody. The antibody of the present invention may also have a region derived from an immunoglobulin from an animal having an ability of gene conversion (e.g., a complementarity-determining region, a framework region, or a variable region). Examples of at least one factor that constitutes the affinity complex include a small substance or a protein (e.g., antibody).
    Type: Application
    Filed: July 4, 2012
    Publication date: February 5, 2015
    Applicant: FUJIREBIO INC.
    Inventor: Yoshie GOISHI
  • Publication number: 20150018244
    Abstract: The present invention pertains to the field of diagnostics for hyperthyroidism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing hyperthyroidism. It also relates to a method for determining whether a compound is capable of inducing such hyperthyroidism in a subject and to a method of identifying a drug for treating hyperthyroidism. Furthermore, the present invention relates to a device and a kit for diagnosing hyperthyroidism.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 15, 2015
    Applicant: BASF SE
    Inventors: Tilmann B. Walk, Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Hennicke Kamp, Jan C. Wiemer, Ralf Looser, Michael Manfred Herold, Alexandre Prokoudine
  • Publication number: 20150017738
    Abstract: Method for obtaining an antibody or antibody fragment to a conformational epitope specific for oxidized, inactive human parathyroid hormone and fragments thereof; a method for removal of oxidized, inactive human parathyroid hormone from a sample of body fluid; methods of determining the concentration of active parathyroid hormone in a sample, and an in vitro method of diagnosis of renal failure or secondary hyperthyroidism in patients on dialysis.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 15, 2015
    Applicant: Immundiagnostik AG
    Inventors: Franz Paul Armbruster, Berthold Hocher, Hans Juergen Groen, Heinz Juergen Roth
  • Patent number: 8916388
    Abstract: In vitro multiparameter method for the diagnosis and early diagnosis, for determination of the severity and for assessing the course and prognosis of neurodegenerative disorders, in which the concentrations of at least two different vasotropic peptides are determined in a biological fluid from a person suffering from subjective or objectively detectable cognitive impairments, the resulting person-specific measurements are combined computationally to give a person-specific complex reference value, and conclusions are drawn concerning the presence of a neurodegenerative disorder in the person on the basis of the person-specific complex reference value found.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: December 23, 2014
    Assignee: Sphingotec GmbH
    Inventors: Andreas Bergmann, Andrea Ernst, Harald Hampel
  • Patent number: 8890061
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 18, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: J. Fred Banks, Peter P. Chou, Noriya M. Matt
  • Patent number: 8865412
    Abstract: Methods and assays for oversulfated glycosaminoglycans are provided. In an embodiment, the present disclosure provides a method for detecting oversulfated glycosaminoglycan (OS-GAG) in a heparin sample. The method comprises placing the heparin sample onto a support comprising immobilized heparin and contacting the heparin sample on the support with a binding compound that attaches to the heparin and forms a heparin-binding compound complex. The binding compound also has a greater affinity for attaching to the OS-GAG than to the heparin in the heparin sample and forms an OS-GAG-binding compound complex. The method can further comprise detecting an amount of the heparin-binding compound complex on the support, and determining an amount of OS-GAG in the heparin sample based on the amount of the heparin-binding compound complex on the support.
    Type: Grant
    Filed: May 28, 2008
    Date of Patent: October 21, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventor: Shawn F. Bairstow
  • Publication number: 20140213468
    Abstract: Devices and methods for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample. The device may include an immunoassay apparatus and a holder with a variable angle stage for positioning the immunoassay apparatus relative to a light source and a detector device. In one embodiment, the device is based upon elastic light scattering, so the variation in the angle of incidence and angle of reflection are optimized to maximize signal generation due to elastic light scattering. The detector device may include a wired or wireless connection to a computer network for communicating with an electronic medical records system, uploading the amount or concentration of at least one analyte present in the sample to the electronic medical records system, or querying a decision support algorithm stored in a computer readable format. The detector device may further include an onboard interpretive algorithm.
    Type: Application
    Filed: November 1, 2013
    Publication date: July 31, 2014
    Inventors: Joel R.L. Ehrenkranz, Pamela J. Turbeville, Jeong-Yeol Yoon, David J. You
  • Patent number: 8741810
    Abstract: The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: June 3, 2014
    Assignee: University of Rochester
    Inventors: Maurice Zauderer, Ernest S. Smith
  • Patent number: 8669519
    Abstract: Provided are methods for determining the amount of reverse T3 in a sample using mass spectrometry. The methods generally involve ionizing reverse T3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse T3 in the sample.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: March 11, 2014
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: J. Fred Banks, Peter P. Chou, Noriya M. Matt
  • Publication number: 20130189672
    Abstract: An assay device includes: a liquid sample zone; a reagent zone downstream and in fluid communication with the sample zone. The reagent zone includes at least two reagent cells containing a reagent material and arranged in the reagent zone such that each reagent cell experiences substantially the same flow conditions of sample from the sample zone. The reagent cells divide the sample flow from the sample zone into multiple flow streams. Also includes are: one or more flow control elements disposed downstream from the reagent zone which combine the multiple flow streams into fewer flow streams; a detection zone in fluid communication with the reagent zone; and a wicking zone in fluid communication with the detection zone having a capacity to receive liquid sample flowing from the detection zone. The sample addition zone, the detection zone and the wicking zone define a fluid flow path.
    Type: Application
    Filed: January 18, 2013
    Publication date: July 25, 2013
    Applicant: Ortho-Clinical Diagnostics, Inc.
    Inventor: Ortho-Clinical Diagnostics, Inc.
  • Publication number: 20130183313
    Abstract: The invention provides an isolated antibody for the TSHR which is an antagonist of TSH. The invention also relates to methods of using antibodies of the invention.
    Type: Application
    Filed: February 14, 2008
    Publication date: July 18, 2013
    Applicant: RSR LIMITED
    Inventors: Bernard Rees Smith, Jadwiga Furmaniak, Jane Sanders
  • Patent number: 8431413
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 30, 2013
    Assignee: Cepheid
    Inventors: Douglas B. Dority, Ronald Chang
  • Publication number: 20130078737
    Abstract: Provided are a base plate and a method for thyroxine immunoassay, which are capable of decreasing the signal change rate caused by temperature change in a high-sensitivity immunoassay method for thyroxine. A base plate for thyroxine immunoassay which has a conjugate of thyroxine or a derivative thereof and albumin immobilized thereon, and in which the ratio of the molecule number of thyroxine or a derivative thereof to the molecule number of albumin in the immobilized conjugate, is disclosed.
    Type: Application
    Filed: September 11, 2012
    Publication date: March 28, 2013
    Applicant: FUJIFILM CORPORATION
    Inventors: Noriyuki KASAGI, Junichi KATADA, Tadahiro MATSUNO
  • Publication number: 20130065321
    Abstract: Systems, methods, and test kits for monitoring and detecting variation in an analyte level in a fluid sample from an individual variation using a uniquely determined analyte threshold value. In one implementation, luteinizing hormone is the monitored analyte and is compared with the determined threshold value to predict the onset of ovulation for the individual.
    Type: Application
    Filed: September 9, 2011
    Publication date: March 14, 2013
    Applicant: CHURCH & DWIGHT CO., INC.
    Inventors: Albert NAZARETH, Andy Sturman, Benedict Zin, Yea-Shun Cheng, Henry Bell, Shang Li
  • Publication number: 20130029353
    Abstract: The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte
    Type: Application
    Filed: October 2, 2012
    Publication date: January 31, 2013
    Applicant: Abbott Laboratories
    Inventor: Abbott Laboratories
  • Publication number: 20130017562
    Abstract: An assay for identifying an individual having or at risk of developing vascular calcification, said assay comprising obtaining a blood sample from an individual and measuring the level of a vesicular compound in a matrix vesicle present in the blood sample from said individual; wherein an increased level of said compound indicates an individual at risk of developing vascular calcification.
    Type: Application
    Filed: February 11, 2011
    Publication date: January 17, 2013
    Applicant: KING'S COLLEGE LONDON
    Inventors: Catherine M. Shanahan, Alexander N. Kapustin
  • Publication number: 20120322163
    Abstract: The present invention relates to immunoassay methods for measurements of concentrations of related analytes in samples of body fluids from different mammalian species. More particularly, it provides reagents and methods that may be used for assays of a mammalian antigen across a range of different mammalian species, using immunological reagents based on non-mammalian antibodies towards said mammalian antigen. Moreover, a calibrator or a set of calibrators is provided, assigned with concentration values for the said antigen for each of the different mammalian species. The advantage of this invention is that the analytical laboratories or veterinarians may use the same reagents and method to test a plurality of different mammalian species without having to use different immunoassay reagents for different mammalian species.
    Type: Application
    Filed: November 11, 2010
    Publication date: December 20, 2012
    Applicant: Gentian AS
    Inventor: Bärd Sundrehagen
  • Publication number: 20120309105
    Abstract: Provided are methods of detecting the presence or amount of organified radioiodine, such as radioactive thyroxine, in a sample using mass spectrometry. For example, one aspect of the invention relates to a rapid and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the simultaneous measurement of radioactive thyroxine and non-radioactive thyroxine in human serum/plasma.
    Type: Application
    Filed: February 7, 2011
    Publication date: December 6, 2012
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: Offie P. Soldin
  • Patent number: 8293541
    Abstract: A non-radioisotopic method measures Free T3 and/or Free T4 in a sample of a non-human species, which can be a canine.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: October 23, 2012
    Inventors: W. Jean Dodds, Ferdie S. Ongchango
  • Publication number: 20120202230
    Abstract: A liquid reagent of a stabilized thyroid hormone-immobilized carrier, by which a thyroid hormone can be measured easily in a short time and at low cost, is provided. The liquid reagent of a thyroid hormone-immobilized carrier according to the present invention includes: a thyroid hormone-immobilized carrier; and a solvent, and a pH of the solvent containing the thyroid hormone-immobilized carrier is in a range from 8.7 to 11.5. The detection of a thyroid hormone using the liquid reagent of the present invention can be carried out by competitively binding a thyroid hormone in a sample and the thyroid hormone-immobilized carrier in the liquid reagent with an anti-thyroid hormone antibody and detecting a composite of the thyroid hormone-immobilized carrier and the anti-thyroid hormone antibody.
    Type: Application
    Filed: February 2, 2012
    Publication date: August 9, 2012
    Applicant: ARKRAY, Inc.
    Inventor: Naotsugu Onuma
  • Patent number: 8227259
    Abstract: Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods comprise ionizing the hormones and analyzing the hormones by mass spectrometry. In addition, methods, systems and kits for the simultaneous or sequential analysis of free thyroxine (FT4) hormone and free-triiodothyronine (FT3) is disclosed comprising ionization of the FT4 and FT3 hormone in the negative mode using an electrospray source.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: July 24, 2012
    Assignee: Georgetown University
    Inventor: Steven J. Soldin
  • Patent number: 8177725
    Abstract: A method including measuring time periods in which a reflex point of a subject is struck and a reflex response is observed. A method including determining a resting metabolic rate of a subject by applying the Kail-Waters equation. An apparatus including a striking instrument capable of delivering a kinetic energy to a reflex point of a subject; and a measurement instrument capable of being coupled to a subject and measuring a reflex response. A machine-readable storage medium containing executable program instructions which when executed cause a digital processing system to perform a method including determining time periods in which a reflex point is struck and a reflex response is observed. A machine-readable storage medium containing executable program instructions which when executed cause a digital processing system to perform a method including determining a resting metabolic rate of a subject by applying the Kail-Waters equation.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: May 15, 2012
    Inventors: Daryl V. Turner, Konrad Kail
  • Patent number: 8158440
    Abstract: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of thyroid hormones and related antibodies in a serum sample, which can be used to evaluate thyroid functions and to diagnose thyroid diseases. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies and antigens used for the detection of respective thyroid hormones and related antibodies in a serum sample.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: April 17, 2012
    Assignee: CMED Technologies Ltd.
    Inventors: Zhong Chen, Ning Liu, Yancun Li
  • Patent number: 8075902
    Abstract: New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
    Type: Grant
    Filed: January 2, 2008
    Date of Patent: December 13, 2011
    Inventor: Michael Powell
  • Publication number: 20110300558
    Abstract: Thus this invention relates to a nanoparticle, useful for bioaffinity assays. The nanoparticle has a self-assembling shell built up of several protein and/or peptide subunits, which protein and/or peptide subunits can be of one or several different types, assembled in an organized manner to form the shell having an inner surface facing the inside and an outer surface facing the outside of said particle. One or several of the types of subunits have one or several first binding moieties per type of subunit with the binding moiety facing the outside of the particle for binding of any specific ligand binding protein; and the particle contains within its shell a marker and/or one or several of the types of subunits have one or several second binding moieties per type of subunit with the binding moiety facing the inside and/or the outside of the particle for binding a marker; and the marker or markers enables detection of the particle.
    Type: Application
    Filed: July 29, 2011
    Publication date: December 8, 2011
    Inventors: Tero Soukka, Teemu Korpimäki, Urpo Lamminmäki, Marko Virta
  • Patent number: 8012769
    Abstract: A non-radioisotopic method of detecting thyroid analytes comprising detecting T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in a sample of a non-human species. Each one of these analytes in an assay profile includes non-radio isotopic measurement of T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in the sample from the non-human species. A non-radioisotopic method detects T3AA and T4AA thyroid autoantibodies in a sample from a non-human species such as the canine species. Antibodies and autoantibodies are bound, and a precipitated or bound antigen-antigen or antibody-autoantibody complex is formed. The supernatant or surrounding fluid of the bound or precipitated antigen-antigen or antibody-autoantibody complex is then removed. The thyroid activity of the bound complex, precipitate, supernatant or surrounding fluid is measured. The thyroid analyte is at least one of T3, Free T3, T4 or Free T4.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: September 6, 2011
    Assignee: Hemopet
    Inventors: W. Jean Dodds, Ferdie S. Ongchangco
  • Publication number: 20110151435
    Abstract: The present invention provides methods of detecting analytes using particles having different physico-chemical properties, such as buoyancy, size, density, spectral characteristics, and/or binding properties, in solution-based sandwich assays and solution-based competition assays. The methods can be performed using rotors and bench-top centrifuges and provide for rapid, qualitative and quantitative detection of analytes. The present invention also provides kits that can be used to perform the methods, and mixtures containing particles suitable for the methods.
    Type: Application
    Filed: December 17, 2010
    Publication date: June 23, 2011
    Applicant: Abaxis, Inc.
    Inventors: Rajesh K. MEHRA, Kenneth P. ARON
  • Publication number: 20110111521
    Abstract: A non-radioisotopic method measures Free T3 and/or Free T4 in a sample of a non-human species, which can be a canine.
    Type: Application
    Filed: May 13, 2010
    Publication date: May 12, 2011
    Inventors: W. Jean Dodds, Ferdie S. Ongchango
  • Patent number: 7824865
    Abstract: The invention provides a method for testing a WT1-related disease, such as leukemia, a solid cancer, or an atypia, for diagnosing the disease, evaluating the course of cure and the prognosis of the disease more simply with high reliability, the method comprises measuring the amount of antibody against WT1 in a sample and using the measurement value and the time course of the value as a clinical marker for the testing.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: November 2, 2010
    Inventor: Haruo Sugiyama
  • Patent number: 7799532
    Abstract: A non-radioisotopic method detects T3AA and T4AA thyroid autoantibodies in a sample from a non-human species such as the canine species. Antibodies and autoantibodies are bound, and a precipitated or bound antigen-antibody or antigen-autoantibody complex is formed. The supernatant or surrounding fluid of the bound or precipitated antigen-antibody or antigen-autoantibody complex is then removed. The thyroid activity of the bound complex, precipitate, supernatant or surrounding fluid is measured. The thyroid analyte is at least one of T3, Free T3, T4 or Free T4.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: September 21, 2010
    Assignee: Hemopet
    Inventors: W. Jean Dodds, Ferdie S. Ongchangco
  • Patent number: 7794954
    Abstract: A non-radioisotopic method of detecting thyroid analytes comprising detecting T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in a sample of a non-human species. Each one of these analytes in an assay profile includes non-radio isotopic measurement of T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in the sample from the non-human species. A non-radioisotopic method detects T3AA and T4AA thyroid autoantibodies in a sample from a non-human species such as the canine species. A non-radioisotopic method detects Free T4 in a sample of a non-human species.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: September 14, 2010
    Assignee: Hemopet
    Inventors: W. Jean Dodds, Ferdie S. Ongchangco
  • Publication number: 20100120168
    Abstract: A non-radioisotopic method of detecting thyroid analytes comprising detecting T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in a sample of a non-human species. Each one of these analytes in an assay profile includes non-radio isotopic measurement of T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in the sample from the non-human species. A non-radioisotopic method detects T3AA and T4AA thyroid autoantibodies in a sample from a non-human species such as the canine species. A non-radioisotopic method detects Free T4 in a sample of a non-human species.
    Type: Application
    Filed: April 24, 2009
    Publication date: May 13, 2010
    Inventors: W. Jean Dodds, Ferdie S. Ongchangco
  • Publication number: 20100120169
    Abstract: A non-radioisotopic method of detecting thyroid analytes comprising detecting T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in a sample of a non-human species. Each one of these analytes in an assay profile includes non-radio isotopic measurement of T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in the sample from the non-human species. A non-radioisotopic method detects T3AA and T4AA thyroid autoantibodies in a sample from a non-human species such as the canine species. Antibodies and autoantibodies are bound, and a precipitated or bound antigen-antigen or antibody—autoantibody complex is formed. The supernatant or surrounding fluid of the bound or precipitated antigen-antigen or antibody-autoantibody complex is then removed. The thyroid activity of the bound complex, precipitate, supernatant or surrounding fluid is measured. The thyroid analyte is at least one of T3, Free T3, T4 or Free T4.
    Type: Application
    Filed: November 9, 2009
    Publication date: May 13, 2010
    Applicant: HEMOPET
    Inventors: W. Jean Dodds, Ferde S. Ongchangco
  • Patent number: 7708699
    Abstract: A method including measuring time periods in which a reflex point of a subject is struck and a reflex response is observed. A method including determining a resting metabolic rate of a subject by applying the Kail-Waters equation. An apparatus including a striking instrument capable of delivering a kinetic energy to a reflex point of a subject; and a measurement instrument capable of being coupled to a subject and measuring a reflex response. A machine-readable storage medium containing executable program instructions which when executed cause a digital processing system to perform a method including determining time periods in which a reflex point is struck and a reflex response is observed. A machine-readable storage medium containing executable program instructions which when executed cause a digital processing system to perform a method including determining a resting metabolic rate of a subject by applying the Kail-Waters equation.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: May 4, 2010
    Assignee: DAAG International, Inc.
    Inventors: Daryl V. Turner, Konrad Kail
  • Publication number: 20100075435
    Abstract: A means for conveniently and accurately measuring thyroxine or thyronine present in the blood or the like is provided: a compound represented by general formula (I) below: wherein L represents a linear or branched-chain linker having 5 to 50 total atoms; X represents one or more thyroxines, thyronines, or residues of derivatives thereof, bound to the main chain and/or side chain of the linker represented by L, a conjugate in the form of the above compound bonded to an avidin protein, and an aqueous dispersion including a microparticles the surface of which is modified with the above conjugate.
    Type: Application
    Filed: July 27, 2009
    Publication date: March 25, 2010
    Inventors: Noriyuki KASAGI, Tadahiro Matsuno
  • Patent number: 7678547
    Abstract: The present invention provides apparatuses for determining velocity independent analyte characteristic parameters and methods for using the same. In one particular aspect, the present invention provides a velocity independent flow cytometry.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: March 16, 2010
    Assignee: California Institute of Technology
    Inventors: Shulamit Eyal, Stephen Quake
  • Patent number: RE44401
    Abstract: Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods include ionizing the hormones and analyzing the hormones by mass spectrometry. In addition, methods, systems and kits for the simultaneous or sequential analysis of thyroid hormones are disclosed including ionization of the thyroid hormones in the negative mode using an electrospray source.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: July 30, 2013
    Assignee: Georgetown University
    Inventor: Steven J. Soldin