Biospecific Ligand Binding Assay Patents (Class 436/501)
  • Patent number: 11434479
    Abstract: Sialic acid recognizing-affinity reagents engineered from the neuraminidase NanB have lectin-like properties and defined specificities for sialic acid.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: September 6, 2022
    Assignees: University of Georgia Research Foundation, Inc., Glycosensors and Diagnostics, LLC
    Inventors: Loretta Yang, Kausar N. Samli, Robert J. Woods, Shengcheng Wu, John C. Cooper, Mallory K. Paul, Matthew J. Saunders, Ziad M. Eletr
  • Patent number: 11435365
    Abstract: This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol 10 cystatin A, cystatin B and other polypeptides and fragments thereof provide biomarkers of renal disease and are described herein.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: September 6, 2022
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Mahalakshmi Yerramilli, Michael Randolph Atkinson, Murthy V. S. N. Yerramilli
  • Patent number: 11420136
    Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: August 23, 2022
    Assignee: FloDesign Sonics, Inc.
    Inventors: Bart Lipkens, Rudolf Gilmanshin, Natalia Rodionova, Benjamin Ross-Johnsrud
  • Patent number: 11415546
    Abstract: Provided are devices and methods to detect the presence of volatile organic compounds related to the presence of a disease state in a biological sample. The devices may include a detection moiety such as a polynucleotide in electronic communication with a semiconductor such as graphene or a carbon nanotube.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: August 16, 2022
    Assignees: The Trustees of the University of Pennsylvania, Monell Chemical Senses Center
    Inventors: Alan T. Johnson, Nicholas J. Kybert, George Preti, Katharine A. Prigge, Janos L. Tanyi, Cynthia Otto
  • Patent number: 11397185
    Abstract: Provided is a method for analyzing a protein-containing sample. The method comprises (1) dissolving a probe capable of non-specifically interacting with a plurality of proteins in a plurality of solvents having different ionic strengths and/or pH levels; (2) adding a protein-containing sample to a plurality of probe solutions prepared in the step (1), thereby the proteins in the sample and the probe are interacted non-specifically; (3) measuring the fluorescence intensities of the plurality of probe solutions to which the protein-containing sample was added in the step (2); and (4) comparing the pattern of fluorescence intensities obtained in the step (3) with the pattern of fluorescence intensities obtained from a reference sample.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: July 26, 2022
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Shunsuke Tomita, Sayaka Ishihara, Ryoji Kurita
  • Patent number: 11396167
    Abstract: A method for producing a laminate, the method comprising at least a pretreatment step of pretreating a surface of a substrate made of a plastic film by reactive ion etching so that the maximum displacement of the substrate surface measured by local thermal analysis is 300 nm or more, and a lamination step of laminating a thermoplastic resin layer made of a material different from that of the substrate on the pretreated surface of the substrate; wherein the plastic film is a polyethylene terephthalate film.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: July 26, 2022
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Miki Fukugami, Toshiya Ishii, Tomoko Ooki
  • Patent number: 11378577
    Abstract: Provided is a reagent for assaying a thrombin-antithrombin complex (TAT) in a blood sample from a subject by latex agglutination assay. The reagent includes a polycation. As a result, TAT complexes can be precisely assayed while circumventing the effect of heparin.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: July 5, 2022
    Assignee: LSI MEDIENCE CORPORATION
    Inventors: Tatsuya Yoshida, Yuhang Yang
  • Patent number: 11353468
    Abstract: Disclosed herein are, inter alia, methods and compositions useful for detecting and/or quantifying host cell proteins during the production of a product, e.g., a recombinant protein, e.g., an antibody.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: June 7, 2022
    Assignee: Lonza Ltd.
    Inventor: Guojie Mao
  • Patent number: 11345732
    Abstract: The present invention discloses a modified interleukin 12 (nsIL-12) and its gene, recombinant vector and use in manufacture of a medicament for treatment of tumors. When the oncolytic adenovirus vector carrying the modified interleukin 12 gene targets tumor tissue, the modified interleukin 12 is continuously expressed at a low level and mainly distributed in the local tumor tissue, which improves the specificity to tumor cells and reduces the systemic toxicity of interleukin 12; the modified interleukin 12 shows stronger inhibitory effect on tumor growth in intraperitoneally disseminated tumors and orthotopic tumors, and has low toxicity. The modified interleukin 12 armed oncolytic viruses show excellent anti-tumor effects, with a significant regression of tumors and lower toxicity compared with the existing IL-12 armed virus.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: May 31, 2022
    Assignees: BEIJING BIO-TARGETING THERAPEUTICS TECHNOLOGY INC., Zhengzhou University
    Inventors: Yaohe Wang, Pengju Wang, Lemoine Nick, Dongling Gao
  • Patent number: 11332505
    Abstract: Provided herein are non-naturally occurring polypeptides comprising a sequence of a fragment of a collagen and recombinant cells containing heterologous nucleic acid sequences encoding the non-naturally occurring polypeptides. Further provided herein are animal-free methods of generating and purifying such non-naturally occurring polypeptides using microorganisms, preferably from bacterial cells.
    Type: Grant
    Filed: October 4, 2021
    Date of Patent: May 17, 2022
    Assignee: GELTOR, INC.
    Inventors: Nikolay Ouzounov, Jeffrey R. Mellin, Julia Co
  • Patent number: 11306129
    Abstract: The present invention discloses a modified interleukin 12 (nsIL-12) and its gene, recombinant vector and use in manufacture of a medicament for treatment of tumors. When the oncolytic adenovirus vector carrying the modified interleukin 12 gene targets tumor tissue, the modified interleukin 12 is continuously expressed at a low level and mainly distributed in the local tumor tissue, which improves the specificity to tumor cells and reduces the systemic toxicity of interleukin 12; the modified interleukin 12 shows stronger inhibitory effect on tumor growth in intraperitoneally disseminated tumors and orthotopic tumors, and has low toxicity. The modified interleukin 12 armed oncolytic viruses show excellent anti-tumor effects, with a significant regression of tumors and lower toxicity compared with the existing IL-12 armed virus.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: April 19, 2022
    Assignees: BEIJING BIO-TARGETING THERAPEUTICS TECHNOLOGY INC., Zhengzhou University
    Inventors: Yaohe Wang, Pengju Wang, Lemoine Nick, Dongling Gao
  • Patent number: 11300519
    Abstract: Provided herein are surface enhanced Raman scattering (SERS)-active reagents and methods for detecting one or more analyte in a sample. Said SERS-active reagents are adaptable, sensitive, and easy-to-use in the diagnosis of infectious diseases in a patient, or the detection of toxins, bacteria, viruses, pathogens, hormones, cytokines, antigens, antibodies or illicit drugs in a biological sample. Such methods may be handled by police, soldiers, or health care workers in the field, and do not require specialized training.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: April 12, 2022
    Assignee: Ionica Sciences
    Inventors: Joel S. Tabb, Omar Green
  • Patent number: 11287429
    Abstract: Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of biotin and at least one target analyte in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: March 29, 2022
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Tie Wei
  • Patent number: 11280758
    Abstract: The invention relates generally to devices, systems, compositions, and methods for the detection of oligonucleotides, nucleic acids, antigens, antibodies, peptides, proteins, and non-biological molecules.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 22, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Seong Jin Koh
  • Patent number: 11255845
    Abstract: A secure assay device is disclosed herein that provides: an assay or a test device that provides at least one result, wherein the assay or test device comprises at least one surface which exhibits optical change in response to at least one target particle, at least one marker or a combination thereof; and at least one multi-layer coating that at least partially covers the assay membrane, the assay device or a combination thereof, wherein the multi-layer coating blocks or impairs the user visualization of the optical change, the at least one result or a combination thereof. A secure reader and method of utilizing the secure assay device and secure reader are disclosed herein.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: February 22, 2022
    Assignee: NOWDiagnostics, Inc.
    Inventors: Neven Karlovac, Onur Mudanyali
  • Patent number: 11237158
    Abstract: Some embodiments of the disclosure provide a time-resolved fluorescent immunochromatographic test strip for detecting paclitaxel drugs as well as a preparation method and application thereof. In some embodiments, the test strip includes a test paper and a sample diluent. The test paper includes a bottom plate, a sample absorption pad, a fluorescent microsphere pad, a bonding pad, and an absorbent pad. The sample absorption pad, the fluorescent microsphere pad, the bonding pad, and the absorbent pad are sequentially overlapped on the bottom plate. The fluorescent microsphere pad is sprayed with a fluorescent microsphere-labeled anti-paclitaxel monoclonal antibody. A detection area and a quality control area are immobilized on the bonding pad. The detection area is sprayed with a paclitaxel hapten-carrier protein conjugate. The quality control area is sprayed with a goat anti mouse antibody.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: February 1, 2022
    Assignee: Beijing Diagreat Biotechnologies Co., Ltd.
    Inventors: Xiuli Xu, Yanxin Wang, Yuanrong Chang, Jianping Zhou
  • Patent number: 11231413
    Abstract: Provided are a biomarker for evaluating a cerebral A? accumulation state using an amyloid precursor protein (APP)-derived peptide in a living body-derived sample as an index, and a method for analysis thereof. A living body-derived sample derived from a test subject is measured, and at least one ratio selected from the group consisting of APP669-711/APP672-713 (A?1-42); APP672-709 (A?1-38)/APP672-713 (A?1-42); APP674-711 (A?3-40)/APP672-713 (A?1-42); APP672-710 (A?1-39)/APP672-713 (A?1-42); APP672-711 (A?1-40)/APP672-713 (A?1-42); and APP672-711 (OxA?1-40)/APP672-713 (A?1-42) is calculated, and when each of the ratios of the test subject is higher than each of standard levels which are ratios of a person having normal cognitive function NC? who is negative for cerebral A? accumulation, an accumulation amount of cerebral A? of the test subject is determined as larger than an accumulation amount of cerebral A? of the person having normal cognitive function NC?.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: January 25, 2022
    Assignees: Shimadzu Corporation, National Center for Geriatrics and Gerontology
    Inventors: Naoki Kaneko, Katsuhiko Yanagisawa
  • Patent number: 11224879
    Abstract: An inspection chip according to the present invention is an inspection chip for stirring liquid by a circular movement of a bottom surface end, including a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body. The bottom surface end has a bottom surface structure in contact with a rotating member for allowing the bottom surface end to perform the circular movement in a position leaning from a center line of the well main body toward the side wall member.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: January 18, 2022
    Assignee: Konica Minolta, Inc.
    Inventors: Takatoshi Kaya, Tomonori Kaneko
  • Patent number: 11203573
    Abstract: The present invention provides compounds used in the synthesis of chemiluminescent acridinium compounds and methods of producing these compounds. Specifically, methods are provided for the N-alkylation of acridan compounds using alkylating reagents. Typically, these alkylating reagents comprise a protected sulfonate group protected with an acid-labile protecting group.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: December 21, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Anand Natrajan
  • Patent number: 11175281
    Abstract: A testing system includes a well cover portion, a sensor portion extending from the well cover portion, a sensing surface disposed on the sensor portion, a conducting wire extending through the sensor portion and contacting the sensing surface, a transducer connected to the conducting wire, and a reference electrode extending through the well cover portion.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: November 16, 2021
    Assignee: International Business Machines Corporation
    Inventors: Sufi Zafar, Norma E. Sosa
  • Patent number: 11162955
    Abstract: A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: November 2, 2021
    Assignee: Wallac Oy
    Inventors: Pertti Hurskainen, Teemu Korpimäki, Heikki Kouru, Mikko Sairanen
  • Patent number: 11154619
    Abstract: Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: October 26, 2021
    Assignee: Creighton University
    Inventors: Igor Meerovich, Alekha Dash, Michael Nichols, David Smith
  • Patent number: 11156622
    Abstract: A device for detecting cotinine includes (a) a film that includes a plurality of molecularly-imprinted-polymer (MIP) coated conductive nanoparticles having specific affinity for binding with cotinine, and (b) two electrodes in contact with the film for passing electrical current through the film to detect binding with cotinine as a change in electrical conductivity of the film. A MIP coated conductive nanoparticle for detecting cotinine includes (a) a conductive nanoparticle, (b) a silicon dioxide coating formed on the conductive nanoparticle and forming a first shell around the conductive nanoparticle, and (c) an MIP coating formed on the silicon dioxide coating and forming the second shell, wherein the MIP coating includes a polymer molecularly imprinted with cotinine to provide specific affinity for binding of cotinine to the MIP coated conductive nanoparticle such that the cotinine is detectable as a change in electrical conductivity of the MIP coated conductive nanoparticle.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: October 26, 2021
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Joseph J. Belbruno, Ziyi Chai
  • Patent number: 11150244
    Abstract: Provided are novel methods for screening and testing for pathogens in food, water, and bodily fluids using methods that are faster to complete than conventional methods of culturing and plating that require lengthy times in properly equipped labs. The invention utilizes specific, rapid and sensitive optical detection to capture small concentrations of the target bacteria and render them amenable for detection with various specific synthesis binding agents approaches. The technique merges capture and detection steps with quantification unit suitable to provide results in a relatively shorter time current detection methods.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: October 19, 2021
    Assignee: S D SYSTEMS, INC.
    Inventor: Majed El-Dweik
  • Patent number: 11136412
    Abstract: Disclosed is an antibody which binds to a symmetrically dimethylated arginine analyte that can be used to detect a symmetrically dimethylated arginine analyte in a sample, such as in a homogeneous enzyme immunoassay method.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: October 5, 2021
    Assignee: ARK Diagnostics, Inc.
    Inventors: Johnny Valdez, Byung Sook Moon, Ki Chung, Yunfei Chen
  • Patent number: 11131675
    Abstract: The invention provides populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens. The peptide populations comprise peptides derived from immunogenic fragments of the Anaplasma Outer Membrane Protein proteins. The invention also provides devices, methods, and kits comprising the populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens and the diagnosis of anaplasmosis. Methods of identifying the particular Anaplasma species infecting a subject using the peptide populations of the invention are also disclosed.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: September 28, 2021
    Assignee: ZOETIS SERVICES LLC
    Inventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile, Andrew P. Rogers, Timothy P. Forsyth, Jeremy D. Walker, Cristina R. Cuesico
  • Patent number: 11125754
    Abstract: The invention discloses a detergent-compatible protein assay method, composition and kit based on bio-conjugation reaction between protein and Meldrum's acid activated furfural. The method includes adding MAF in dimethyl sulfoxide (DMSO) to a protein sample solution. The amine functionalities present on the amino acid residues reacts with the MAF instantaneously at room temperature to yield deep purple colored solutions of the corresponding conjugated proteins. The reagent composition added to protein may be in the range of 90-450 mM. The intensities of purple colored solutions were proportional to the protein concentration captured by spectrophotometric measurements. The assay is sensitive in the range of 0.125-15 mg/mL, is compatible with commonly used detergents and reducing agents in protein solutions and may be employed for estimation of protein samples in the presence of detergents and reducing agents.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: September 21, 2021
    Inventors: Sobha Vijayan Nair, Prakash Chandran Ramachandran Nair, Bipin Nair, Kalyani Ajayan
  • Patent number: 11119100
    Abstract: A portable monitoring strip reader may include one or more light sensors for reading urine monitoring strips. The monitoring strip reader may collect light intensity information and transmit the information to an application on a portable electronic device for analysis. The application may determine concentrations of analytes and diagnose conditions or illnesses where a concentration is too high or too low. In some aspects, the application may use machine learning models such as an anomaly detection model, diagnosis model, and measurement model.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: September 14, 2021
    Assignee: Eido Innova, Inc.
    Inventors: Nancy Guerra Infante, Carlos Francisco Bemal Velazquez
  • Patent number: 11104728
    Abstract: The present invention relates to an anti-EMAP II antibody or an antigen-binding fragment thereof, a nucleic acid molecule for coding the same, or a preparation method thereof. Also, the present invention provides a method for using the anti-EMAP II antibody or the antigen-binding fragment thereof in preventing, treating or diagnosing EMAP II-mediated diseases, for example, TNF-?-mediated disease or Alzheimer's disease. Furthermore, the present invention provides a method for using the anti-EMAP II antibody or the antigen-binding fragment thereof in detecting or quantifying an EMAP II antigen. The antibody of the present invention may exhibit a more improved antigen-binding capacity compared to existing anti-EMAP antibodies and may treat the TNF-?-mediated disease more effectively.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: August 31, 2021
    Assignee: HUB Biotech Co., Ltd.
    Inventors: Sang Gyu Park, Gook-Jin Kang
  • Patent number: 11099145
    Abstract: Systems and methods electronic barcoding of particles. The methods comprise: performing operations by a spin coater to spin coat a single layer of particles onto a substrate; performing operations by a heat applicator to apply heat to the substrate so as to evaporate a liquid; and performing operations by at least one material depositor to transform the particles into Electronically Barcoded Particles (“EBPs”). EBPs are fabricated by: coating a portion of each said particle of the particles with a first conductive layer; depositing an insulative layer on the first conductive layer; and/or depositing a second conductive layer on the insulative layer so as to form a parallel plate capacitor on the particle. The parallel plate capacitor is tuned so that the particle has a capacitance that is different than the capacitances of other ones of the electronically barcoded particles.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 24, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Mehdi Javanmard
  • Patent number: 11099191
    Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: August 24, 2021
    Assignees: Osaka University, Kagami Inc.
    Inventors: Yoshitaka Isaka, Tomonori Kimura, Keiko Yasuda, Kenji Hamase, Masashi Mita
  • Patent number: 11079376
    Abstract: The optical analyte detector is a photonic detector that uses a measured wavelength shift to determine the presence of an analyte. An open cell is formed in an optical layer for receiving a sample to be analyzed. A transition metal dichalcogenide monolayer defines a bottom wall of the open cell, and the transition metal dichalcogenide monolayer is formed directly above a microring resonator. A waveguide is positioned adjacent to the open cell, and is spaced apart therefrom by a gap. The waveguide is coupled to the microring resonator, and the transition metal dichalcogenide monolayer is functionalized with an adsorbed layer for detection of a specific analyte. Molecular binding takes place if a sample of the analyte contacts the adsorbed layer, which induces a wavelength shift in light transmitted through the waveguide. The presence of this measured wavelength shift indicates positive detection of the analyte.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: August 3, 2021
    Assignee: UNITED ARAB EMIRATES UNIVERSITY
    Inventor: Adel Najar
  • Patent number: 11073523
    Abstract: This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome. Current practice for differentially diagnosing ectopic ACTH syndrome and Cushing's Disease measures relative ACTH concentrations from the inferior petrosal venous sinus compared to fluid obtained from a periphery venous sample. This is performed before and after administration of exogenous corticotropin releasing factor, or after administration of metyrapone. This invention uses glucocorticoid receptor antagonists to induce release of endogenous CRH which stimulates ACTH to increase in patients with ectopic ACTH syndrome but not in those with Cushing's Disease.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: July 27, 2021
    Assignee: Corcept Therapeutics, Inc.
    Inventor: Andreas G. Moraitis
  • Patent number: 11054415
    Abstract: The present invention relates to bioconjugates and labeled derivatives of anatoxin-a, at different positions of the molecule, suitable for producing antibodies with high affinity and specificity for anatoxin-a. At the same time, the present invention also relates to the use of bioconjugates of anatoxin-a and labeled derivatives of anatoxin-a as assay antigens. Moreover, the present invention also relates to methods for analyzing, concentrating and extracting anatoxin-a using the antibodies obtained, sometimes together with assay antigens which are bioconjugates or labeled derivatives. This invention also provides a kit for analyzing anatoxin-a which comprises antibodies against this cyanotoxin sometimes together with assay antigens which are bioconjugates or labeled derivatives of anatoxin-a.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: July 6, 2021
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, UNIVERSITAT DE VALÈNCIA
    Inventors: Antonio Abad Fuentes, Josep Vicent Mercader Badia, Antonio Abad Somovilla, Consuelo Agulló Blanes, Guillermo Quiñones Reyes
  • Patent number: 11052102
    Abstract: The present invention provides novel compounds that target thrombocyte activity or aggregation capacity through cellular components for the treatment of diseases associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The invention provides these compounds for treating non-alcoholic steatohepatitis (NASH), a progressed stage of NAFL (non-alcoholic fatty liver), in order to avoid the development of liver cirrhosis and Hepatocellular Carcinoma (HCC). Further provided are pharmaceutical compositions, comprising the compounds of the invention, and methods for screening new NASH therapeuticals.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: July 6, 2021
    Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
    Inventors: Mathias Heikenwälder, Lars Zender, Achim Weber
  • Patent number: 11047802
    Abstract: The invention relates to a tube furnace device for an atomizing furnace and to an analyzing apparatus comprising an atomizing furnace and a tube furnace device, in particular for atomic absorption spectrometry, the tube furnace device comprising a sample carrier means (11) and a bearing means (12) for supporting and forming electrical contact with the sample carrier means, the sample carrier means having a receiving tube (16) forming a tubular receiving space (17) for receiving an analyte, the sample carrier means having two bearing protrusions on the receiving tube for forming a connection with the bearing means, the bearing protrusions extending perpendicularly, preferably orthogonally, in relation to a longitudinal axis of the receiving tube, wherein the tube furnace device has a contact pressure means (13) via which a contact pressure force (14) can be exerted on the bearing protrusions in the direction of a passant line (20) in relation to a circular cross section (21) of the receiving tube.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: June 29, 2021
    Assignee: SCHUNK KOHLENSTOFFTECHNIK GMBH
    Inventors: Ralf Gaertner, Rudolf Weck, Akira Honda, Osuke Kobayashi
  • Patent number: 11041188
    Abstract: Disclosed herein are methods and compositions for associating a genetic variant with intraretinal fluid. Also disclosed herein are methods and compositions for associating a genetic variant with visual acuity, anatomic outcomes or treatment frequency.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: June 22, 2021
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Lorah Perlee, Sara Hamon
  • Patent number: 11040892
    Abstract: A mobile device reads a test strip to determine a chemical condition of a liquid or a user inputs a treatment plan into the mobile device. The mobile device transmits the determined chemical condition or the input treatment plan to a liquid treatment system which treats the fluid in response to the determined chemical condition or the input treatment plan.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: June 22, 2021
    Assignee: Digital Concepts of Missouri, Inc.
    Inventors: Paul Decker, Jack Greenwood
  • Patent number: 11026596
    Abstract: Systems, techniques and compositions can detect and measure a target substance, such as THC, in a constituent sample from exhaled human breath.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: June 8, 2021
    Assignee: HOUND LABS, INC.
    Inventors: Michael Scott Lynn, Hamilton Roger Tang, Kevin Bradford Dunk, Kevin M. Limtao, Hayuta Jain
  • Patent number: 11029306
    Abstract: A liquid voltage is applied to a first side of a lipid bilayer. The liquid voltage comprises a tag-reading period with a tag-reading voltage that tends to capture a tag into a nanopore in the lipid bilayer and an open-channel period with an open-channel voltage that tends to repel the tag. A pre-charging voltage source is connected to an integrating capacitor and a working electrode on a second side of the lipid bilayer during a pre-charging time period, such that the integrating capacitor and the working electrode are charged to a pre-charging voltage. The pre-charging voltage source is disconnected from the integrating capacitor and the working electrode during an integrating time period, such that a voltage of the integrating capacitor and a voltage of the working electrode may vary as a current flows through the nanopore. The pre-charging time period overlaps with a beginning portion of the tag-reading period.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: June 8, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Roger J. A. Chen, Hui Tian, J. William Maney, Jr.
  • Patent number: 11016073
    Abstract: A system, device, and method for detecting and quantifying an analyte in a liquid include a vial having one or more pre-dosed reagents disposed in the vial. The vial is configured to hold a volume of a liquid including an analyte. The one or more pre-dosed reagents are dissolvable in the volume of the liquid to form a sample liquid solution comprising chromophores or fluorophores. The analyte and the one or more pre-dosed reagents react to yield the chromophores or fluorophores. The system further includes a detection device including a chamber configured to retain the vial, the detection device configured to quantify the analyte in the sample liquid solution. A device and method may perform the functions of the system.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: May 25, 2021
    Assignee: Field Water Testing, LLC
    Inventors: Christopher Lloyd, Andrew Duncan
  • Patent number: 11008575
    Abstract: Disclosed herein are unique single stranded DNA oligonucleotide products identified as binding with high affinity and specificity to ovarian tumor cells that may be used in the delivery of therapy to and diagnosis of ovarian cancer.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: May 18, 2021
    Assignee: The University of North Carolina at Charlotte
    Inventors: Christine Richardson, Gregory Benedetto
  • Patent number: 11002749
    Abstract: A computer-implemented method of calibrating an in-vitro diagnostic analyzer is disclosed. The method includes executing a multi-point calibration procedure including measuring a plurality of calibrator levels and thereby obtaining a plurality of respective calibration points. The method further includes calculating a result of the multi-point calibration procedure and determining failure or passing of the multi-point calibration procedure based on the calculated result. In case of failure of the multi-point calibration procedure, the method includes determining if failure is related to one or more individual failed calibration point(s), and in the affirmative, triggering a repetition of measuring the calibrator level(s) only with respect to the failed calibration point(s) and re-calculating the result of the multi-point calibration procedure after replacing only the failed calibration point(s) with the newly obtained calibration point(s).
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: May 11, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Mirko Klingauf
  • Patent number: 10993960
    Abstract: A pharmaceutical composition includes polymer units ? and ?, each having a hydrophilic polymer chain bound to a cationic polymer chain, and a drug. The polymer units ? and ? are radially arranged such that the cationic polymer chains are directed inward and the hydrophilic polymer chains are directed outward, thereby forming a micelle with the drug encapsulated in the micelle. The cationic polymer chain of the polymer unit ? has a phenylboronic acid group in a side chain, and the cationic polymer chain of the polymer unit ? has a phenylboronic acid binding site in a side chain. The phenylboronic acid group and the phenylboronic acid binding site form a cross-linked structure that can dissociate in an acidic environment and/or in the presence of a substance capable of competitive binding.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: May 4, 2021
    Assignee: KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
    Inventors: Kazunori Kataoka, Takehiko Ishii, Mitsuru Naito, Naoto Yoshinaga, Taisuke Endo
  • Patent number: 10982136
    Abstract: Embodiments relate generally to lanthanide nanocrystals as ultraviolet downconverters.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: April 20, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Agbo, Rebecca J. Abergel
  • Patent number: 10963992
    Abstract: Method and system for compensating intensity biases in a plurality of digital images. Each digital image of the plurality of digital images contains a plurality of objects and each of the plurality of objects is configured to receive at least one molecule comprising genetic information, wherein the at least one molecule is configured to receive one of at least a first fluorescent compound and a second fluorescent compound. A first digital image of the plurality of digital images is taken by an optical imaging system during emission of electromagnetic radiation by the first fluorescent compound, and a second digital image of the plurality of digital images is taken by the optical imaging system during emission of electromagnetic radiation by the second fluorescent compound.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: March 30, 2021
    Assignee: QIAGEN GmbH
    Inventors: Thorsten Zerfass, Maiko Lohel, Fernando Carrillo Oesterreich
  • Patent number: 10948499
    Abstract: An inorganic nanoparticle is provided (step A) having the size of the aggregate of the protein misfolding disease. Free amino groups or free carboxyl groups are formed (step B) on the surface of the nanoparticle (for functionalizing the nanoparticle surface into an amine- or carboxy-functionalized nanoparticle. Maleinimido spacer carboxylic acid is bound to the free amino groups in step (B). Or, free carboxyl groups in step (B) are converted into NHS esters. Monomers of the protein aggregate are bound i) to the maleinimido spacer carboxylic acids by way of a sulfhydryl group at the free end of the monomers, or ii) to the NHS esters by way of the amino group at the free end of the monomer. A standard is provided for use in the detection of protein aggregates occurring with protein misfolding diseases.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: March 16, 2021
    Inventors: Maren Huelsemann, Christian Zafiu, Oliver Bannach, Dieter Willbold
  • Patent number: 10935555
    Abstract: A method of determining suitability of a pregnant woman to be a candidate for induction of labor can include: obtaining a vaginal fluid sample from a pregnant woman; contacting the vaginal fluid sample with a PAMG-1 antibody that binds with PAMG-1; detecting whether the PAMG-1 antibody binds with PAMG-1 in the vaginal fluid sample to form a PAMG-1-antibody complex; and providing the determination of suitability for induction of labor to the pregnant woman. When the PAMG-1-antibody complex forms, the pregnant woman is determined to be in a condition that is not suitable for induction of labor because PAMG-1 is detected in the vaginal sample. When the PAMG-1-antibody complex does not form, the pregnant woman is determined to be in a condition that is suitable to be a candidate for induction of labor because the PAMG-1 is not detected in the vaginal sample.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: March 2, 2021
    Assignee: Qiagen Sciences, LLC
    Inventors: Ruben Salinas, Anthony Ausiello
  • Patent number: 10928394
    Abstract: The subject matter disclosed herein provides a method and a device for detection of one or more bacteria in a sample.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: February 23, 2021
    Inventor: Julian R. K. Kage
  • Patent number: 10920274
    Abstract: A composition comprising submicron particles covered by a monolayer of nucleic acid wherein the nucleic acid may be recovered from the submicron particles is claimed. Methods of attaching a nucleic acid to an object for authentication and methods of authenticating an object are also claimed.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: February 16, 2021
    Assignee: APDN (B.V.I.) Inc.
    Inventors: Michael E. Hogan, Lawrence Jung, Nicole Richter, Yuhua Sun, Maciej Szczepanik