Including Use Of Radioactive Properties Patents (Class 436/57)
  • Patent number: 9857294
    Abstract: Described herein is an approach using inexpensive, disposable chemical sensor probes that can be mounted on a small unmanned aerial vehicles (UAVs) and used to analyze a site (such as one known or suspected to contain explosive residue, spilled material or contaminated soil) without the need for a person to conduct ground operations at the site. The method involves contacting a soil or a surface with a filter paper wetted with a solvent, then subjecting the filter paper to spectroscopy, thus detecting a possible variation indicative of one or more analytes, wherein the solvent is a deep eutectic solvents consisting of a mixture of ethylene glycol and choline chloride.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: January 2, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, Scott A. Trammell, Walter J. Dressick, David A. Stenger, Jasenka Verbarg
  • Patent number: 9581601
    Abstract: Present invention refers to a novel and improved method of derivatization and detection of amino acid sequence and/or identification of proteins, peptides by a new derivatization compound. Precisely, the method discloses a novel approach to derivatization of peptides or proteins by compounds comprising two or more sulfonyl groups and analysis of derivatized analytes in negative mode of operation of mass spectrometer. This method allows unambiguous analysis of amino acid sequence of long-chain peptides/proteins. Also, the invention discloses a novel synthesis procedure of 5-formyl-benzene-1,3-disulphonic acid as derivatization compound.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: February 28, 2017
    Assignee: Rudjer Boskovic Institute
    Inventors: Mario Cindric, Zdenko Hamersak, Ivana Dodig
  • Patent number: 9513274
    Abstract: There is provided a method for determining Total Acid Number (TAN) in a fluid fossil fuel, such as a crude oil, comprising: separating said fluid fossil fuel by liquid chromatography into a plurality of fractions, comprising at least one acidic fraction; determining boiling point distribution of said crude oil, of said acidic fraction, and of said polyacidic fraction by simulated distillation (SD); and correlating said boiling point distributions to acid molecular weights to determine the TAN.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: December 6, 2016
    Assignee: Phillips 66 Company
    Inventors: John Brian Green, Ricky Eugene Snelling, Laura Lee Young, Dale Lee Embry, Herbert Robert Pinnick, Jr.
  • Patent number: 9068942
    Abstract: The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, refractory asthma, and other related diseases. Examples of such methods include determining if the candidate compound decreases the degradation of elastic fiber in a patient administered the candidate compound by measuring, using mass spectrometry employing an internal standard, a marker of elastic fiber degradation in a sample of a body fluid or a tissue of the patient. The invention provides that a decrease in the presence of the marker compared to a control validates that the candidate compound is effective to treat, prevent, or ameliorate the disease.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 30, 2015
    Assignees: The Trustees of Columbia University in the City of New York, St. Luke's-Roosevelt Hospital Center
    Inventors: Gerard M Turino, Shuren Ma, Yong Y Lin, Seymour Leiberman
  • Publication number: 20140315316
    Abstract: A method for colorimetric radiation dosimetry includes subjecting an aggregate including a polymeric matrix having uniformly dispersed nanoparticles therein to radiation. The aggregate is soaked in a solution selected to dissolve decomposed pieces of the polymeric matrix to release into the solution nanoparticles from the decomposed pieces. Color of the solution is compared to a reference to determine a dose of radiation based on number of liberated nanoparticles.
    Type: Application
    Filed: August 16, 2013
    Publication date: October 23, 2014
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Qing Cao, Kangguo Cheng, Zhengwen Li, Fei Liu, Zhen Zhang
  • Patent number: 8785208
    Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: July 22, 2014
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Vladimir Martin
  • Patent number: 8784840
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: July 22, 2014
    Assignee: The Cleveland Clinic Foundation
    Inventor: Andrei V. Gudkov
  • Publication number: 20140154808
    Abstract: Compositions, devices and processes related to etching of a very thin layer or fine particles of a metal are disclosed for monitoring a variety of parameters, such as time, temperature, time-temperature, thawing, freezing, microwave, humidity, ionizing radiation, sterilization and chemicals. These devices have capabilities of producing a long and sharp induction period of an irreversible visual change. The devices are composed of an indicator comprising a very thin layer of a metal and an activator, e.g., a reactant, such as water, water vapor, an acid, a base, oxidizing agent or their precursors, which is capable of reacting with the said indicator. Ink formulations composed of a metal powder and a proper activator can be used for monitoring several sterilization processes, such as sterilization with steam. When water is used as an activator, a thin layer of metals, such as that of aluminum can be used as steam sterilization or humidity indicator.
    Type: Application
    Filed: December 3, 2012
    Publication date: June 5, 2014
    Inventor: Gordhanbhai N. Patel
  • Patent number: 8586366
    Abstract: Gel for radiation dosimeter including a gel part (A) and a gel part (B) that become cloudy when exposed to a fixed dose or more, wherein said gel part (A) exposed to more than a specified dose above the fixed dose maintains a cloudy state regardless of the decrease in external temperature; and said gel part (B) exposed to less than the specified dose above the fixed dose changes gradually from a cloudy state into a transparent state according to the decrease in external temperature.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: November 19, 2013
    Assignee: Japan Atomic Energy Agency
    Inventors: Akihiro Hiroki, Naotsugu Nagasawa, Masao Tamada, Takuji Kojima, Yuichi Sato, Akio Ohta, Hisamichi Yamabayashi, Takayoshi Yamamoto
  • Patent number: 8551785
    Abstract: In one example, a method of examining contents of an object is disclosed comprising scanning an object by first and second radiation beams at least first and second angles, detecting radiation at the first and second angles, and determining whether the object at least potentially comprises high atomic number material, which may be nuclear material or shielding material, based, at least in part, on the detected radiation. In one example, the detected radiation at both angles must be indicative of a region of high atomic number material by the presence of corresponding high density regions, in order for it to be concluded that high atomic number material that may be nuclear material may be present. The determination may be further based on the size of a high density region in one of the images. Systems are also disclosed.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: October 8, 2013
    Assignee: Varian Medical Systems, Inc.
    Inventor: Paul Bjorkholm
  • Publication number: 20130203164
    Abstract: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions (such as immune, cardiovascular, cancer, and other proliferative diseases, disorders, and/or conditions) related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
    Type: Application
    Filed: March 22, 2013
    Publication date: August 8, 2013
    Applicant: Human Genome Sciences, Inc.
    Inventors: Craig A. ROSEN, Steven M. Ruben
  • Patent number: 8481323
    Abstract: The present invention is drawn to a method of measuring glycated hemoglobin, which can comprise steps of establishing multiple age-specific groups of red blood cells, and measuring HbA1c levels of at least one of said groups. In another embodiment, a system for measuring glycated hemoglobin can comprise a separating device configured to separate red blood cells into multiple age-specific groups, and a measuring device configured to measure HbA1c levels of at least one of said groups.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: July 9, 2013
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: David A. Tyvoll, Bryan J. Johnson, Kevin F. Peters
  • Publication number: 20130157279
    Abstract: A method for detecting a target substance involves: a step of preparing a complex (4) including a first aptamer (1) that binds specifically with a target substance (5) contained in a test sample and a second aptamer (2) that binds specifically with a second ligand (6) other than the target substance (5), the first aptamer (1) having at least one double-strand forming section which is formed of a double strand, the second aptamer (2) having at least two double-strand forming sections, the base sequence of the first aptamer (1), which binds with the target substance (5), including at least a portion of the base sequence of the double-strand forming section of the first aptamer (1), the base sequence of the second aptamer (2), which binds with the second ligand (6), including at least a portion of the base sequence of said at least two double-strand forming sections of the second aptamer (2); a step of binding the target substance (5) and the first aptamer (1); a step of binding the second ligand (6) and the sec
    Type: Application
    Filed: June 17, 2011
    Publication date: June 20, 2013
    Applicant: NEC CORPORATION
    Inventor: Kimiyasu Takoh
  • Publication number: 20130130309
    Abstract: HPLC-based quality control systems to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an integrated PET biomarker radiopharmaceutical production system, the present general inventive concept permits a manufacturer to produce product and conduct quality control tests with lower per dose costs.
    Type: Application
    Filed: April 13, 2012
    Publication date: May 23, 2013
    Applicant: ABT MOLECULAR IMAGING INC
    Inventors: Ronald Nutt, Antony M. Giamis, Aaron McFarland
  • Patent number: 8426208
    Abstract: The present invention relates to devices, systems, and methods for determination of ionizing radiation. In some embodiments, the devices comprise nanocomposite materials containing nanostructures (e.g., carbon nanotubes) dispersed in radiation sensitive polymers. In some cases, the device may include a conductive pathway that may be affected upon exposure to ionizing radiation. Embodiments described herein may provide inexpensive, large area, low power, and highly sensitive radiation detection materials/devices.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: April 23, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Jose M. Lobez
  • Patent number: 8409525
    Abstract: A system for warning of corrosion, chemical, or radiological substances. The system comprises painting a surface with a paint or coating that includes an indicator material and monitoring the surface for indications of the corrosion, chemical, or radiological substances.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: April 2, 2013
    Assignee: Lawrence Livermore National Security, LLC
    Inventor: Joseph C. Farmer
  • Patent number: 8409524
    Abstract: A paint that warns of radiological or chemical substances comprising a paint operatively connected to the surface, an indicator material carried by the paint that provides an indication of the radiological or chemical substances, and a thermo-activation material carried by the paint. In one embodiment, a method of warning of radiological or chemical substances comprising the steps of painting a surface with an indicator material, and monitoring the surface for indications of the radiological or chemical substances. In another embodiment, a paint is operatively connected to a vehicle and an indicator material is carried by the paint that provides an indication of the radiological or chemical substances.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: April 2, 2013
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Joseph C. Farmer, James L. Brunk, S. Daniel Day
  • Patent number: 8394638
    Abstract: A system may include a means for administering a therapeutic agent to a subject; a means for administering a first pharmaceutically-acceptable taggant to the subject at least substantially concurrent with the therapeutic agent, the first pharmaceutically-acceptable taggant having a pharmacokinetic profile; and a means for administering a second pharmaceutically-acceptable taggant to the subject with the first pharmaceutically-acceptable taggant, the second pharmaceutically-acceptable taggant having a pharmacokinetic profile different from the pharmacokinetic profile of the first pharmaceutically-acceptable taggant.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: March 12, 2013
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Dennis J. Rivet, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 8377704
    Abstract: Provided herein are methods of detecting anions in solution. In particular, the methods can be used to detect trace anions in solution. For example, the anions can be present in an amount of between about 500 femtomoles to about 10 millimoles.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: February 19, 2013
    Assignee: NUtech Ventures
    Inventors: Stephen DiMagno, Ronald Cerny
  • Publication number: 20120322159
    Abstract: The present invention relates to improved methods for measuring the renewable bio-source carbon content and renewable bio-content in renewable bioplastic resins produced in manufacturing plants. In particular, the present invention relates to measuring the renewable bio-source carbon content in renewable bioplastic resins produced during a production run by correlating measured ?13C values are measured by iTOC-CRDS and CM-CRDS with actual renewable bio-source carbon content measurements (AMS or LSC14C) via a linear regression.
    Type: Application
    Filed: September 16, 2011
    Publication date: December 20, 2012
    Inventors: Robert Kriegel, Sheng Sheng Yang, Hsiao Hua Liu, Christopher Mubarak
  • Publication number: 20120295360
    Abstract: The present invention relates to devices, systems, and methods for determination of ionizing radiation. In some embodiments, the devices comprise nanocomposite materials containing nanostructures (e.g., carbon nanotubes) dispersed in radiation sensitive polymers. In some cases, the device may include a conductive pathway that may be affected upon exposure to ionizing radiation. Embodiments described herein may provide inexpensive, large area, low power, and highly sensitive radiation detection materials/devices.
    Type: Application
    Filed: April 24, 2012
    Publication date: November 22, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Jose M. Lobez
  • Patent number: 8268623
    Abstract: A method and means for identifying the authenticity and the genuine nature of a solid or liquid bulk material, by incorporating a marking composition containing at least one trace ion into the said bulk material, whereby the total concentration of the incorporated trace ions in the market bulk material is chosen to be lower than the corresponding concentration of the same ions in standard sea water. The authenticity and the genuine nature or the adulteration level of the marked bulk material can be tested in-the-field using electrochemical sensors, and confirmed in the laboratory using a method such as atomic absorption spectroscopy, ion chromatography or mass spectrometry.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: September 18, 2012
    Assignee: SICPA Holding SA
    Inventors: Thomas Tiller, Sylvain Jaquier, Xavier Marguerettaz
  • Publication number: 20120225486
    Abstract: A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope 41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope 41Ca by the patient, obtaining a sample of the radioactive calcium isotope 41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.
    Type: Application
    Filed: April 16, 2012
    Publication date: September 6, 2012
    Inventors: Darren J. Hillegonds, John S. Vogel, Robert L. Fitzgerald, Leonard J. Deftos, David Herold, Douglas W. Burton
  • Patent number: 8260559
    Abstract: A system and method for measurement of radioactivity concentration of a radiopharmaceutical are disclosed. The radiopharmaceutical may be a radioactive tracer solution including a tracer solution and a buffer solution. The system may include a vial that receives the tracer solution and the buffer solution; a scale; a radioactivity measuring device; and a controller that determines the radioactive concentration based on a measured radioactivity of the tracer solution and the buffer solution in the vial, and a weight of the tracer solution and the buffer solution in the vial. The method may include the steps of (1) transferring the tracer solution into a vial; (2) measuring a radioactivity of the tracer solution in the vial; (3) determining a weight necessary to achieve a desired radioactivity concentration; and (4) diluting the tracer solution in the vial to the determined weight with a buffer solution.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: September 4, 2012
    Assignee: General Electric Company
    Inventors: Michael Brussermann, Guido Schwartenbeck, Stefan Riese
  • Patent number: 8247234
    Abstract: Compounds having stable isotopes 13C and/or 2H were synthesized from precursor compositions having solid phase supports or affinity tags.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: August 21, 2012
    Assignee: Los Alamos National Security, LLC
    Inventors: Jurgen G. Schmidt, David B. Kimball, Marc A. Alvarez, Robert F. Williams, Rudolfo A. Martinez
  • Publication number: 20120142112
    Abstract: A senor uses a transduction mechanism of attenuating electroluminescence.
    Type: Application
    Filed: December 7, 2010
    Publication date: June 7, 2012
    Applicant: United States of America, as represented by the Secretary of the Army
    Inventor: Vincent P. Schnee
  • Publication number: 20120135528
    Abstract: A paint that warns of radiological or chemical substances comprising a paint operatively connected to the surface, an indicator material carried by the paint that provides an indication of the radiological or chemical substances, and a thermo-activation material carried by the paint. In one embodiment, a method of warning of radiological or chemical substances comprising the steps of painting a surface with an indicator material, and monitoring the surface for indications of the radiological or chemical substances. In another embodiment, a paint is operatively connected to a vehicle and an indicator material is carried by the paint that provides an indication of the radiological or chemical substances.
    Type: Application
    Filed: February 2, 2012
    Publication date: May 31, 2012
    Applicant: Lawrence Livermore National Security, LLC
    Inventors: Joseph C. Farmer, James L. Brunk, S. Daniel Day
  • Patent number: 8187887
    Abstract: The present invention relates to devices, systems, and methods for determination of ionizing radiation. In some embodiments, the devices comprise nanocomposite materials containing nanostructures (e.g., carbon nanotubes) dispersed in radiation sensitive polymers. In some cases, the device may include a conductive pathway that may be affected upon exposure to ionizing radiation. Embodiments described herein may provide inexpensive, large area, low power, and highly sensitive radiation detection materials/devices.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: May 29, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Jose M. Lobez
  • Patent number: 8173073
    Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: May 8, 2012
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael Van Dam, Lawrence Diener, Sean Ford, Reza Miraghaie
  • Patent number: 8153436
    Abstract: Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging compound reactive with a plurality of crystal species under conditions that allow the detectable crystal-tagging compound to react with a plurality of crystal species, if present, to form tagged crystal species complexes. Substantially all unreacted tagging compound is then removed. If desired, chemical, enzymatic, or physical treatment can be used to selectively degrade some, but not, of the tagged crystal species. Assessment of soluble versus crystal-associated label is then performed.
    Type: Grant
    Filed: February 14, 2008
    Date of Patent: April 10, 2012
    Assignees: The United States of America as represented by the Department of Veterans Affairs, University of Miami
    Inventor: Herman S. Cheung
  • Patent number: 8143063
    Abstract: A paint that warns of radiological or chemical substances comprising a paint operatively connected to the surface, an indicator material carried by the paint that provides an indication of the radiological or chemical substances, and a thermo-activation material carried by the paint. In one embodiment, a method of warning of radiological or chemical substances comprising the steps of painting a surface with an indicator material, and monitoring the surface for indications of the radiological or chemical substances. In another embodiment, a paint is operatively connected to a vehicle and an indicator material is carried by the paint that provides an indication of the radiological or chemical substances.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: March 27, 2012
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Joseph C. Farmer, James L. Brunk, S. Daniel Day
  • Patent number: 8137976
    Abstract: In one example, a method of examining contents of an object is disclosed comprising scanning an object by first and second radiation beams at at least first and second angles, detecting radiation at the first and second angles, and determining whether the object at least potentially comprises high atomic number material, which may be nuclear material or shielding material, based, at least in part, on the detected radiation. In one example, the detected radiation at both angles must be indicative of a region of high atomic number material by the presence of corresponding high density regions, in order for it to be concluded that high atomic number material that may be nuclear material may be present. The determination may be further based on the size of a high density region in one of the images. Systems are also disclosed.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: March 20, 2012
    Assignee: Varian Medical Systems, Inc.
    Inventor: Paul Bjorkholm
  • Patent number: 8133735
    Abstract: A system for warning of corrosion, chemical, or radiological substances. The system comprises painting a surface with a paint or coating that includes an indicator material and monitoring the surface for indications of the corrosion, chemical, or radiological substances.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: March 13, 2012
    Assignee: Lawrence Livermore National Security, LLC
    Inventor: Joseph C. Farmer
  • Patent number: 8124032
    Abstract: The invention relates to a microfluidic device comprising one or more fluid channels, one or more fluid ports, and a V-shaped particle retention structure. The fluid channel is generally opposite the particle retention structure, fluid ports are located between the fluid channel and the particle retention structure, and the particle retention structure has sloped side walls. Fluid, including reagents, can be delivered to the microfluidic device through the one or more fluid channels or the fluid ports. The invention also relates to methods of using the microfluidic device to monitor, observe, measure, or record a biological parameter of a particle, to separate a single particle from a group of particles, to culture a cell, to treat a particle, and to move a particle back and forth in the device.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: February 28, 2012
    Assignee: Simon Fraser University
    Inventors: Paul Chi Hang Li, Xing Yue Peng
  • Publication number: 20120034700
    Abstract: Methods to radiolabel natural organic matter by reduction with a hydrogen labeled reducing agent, and compositions, are provided.
    Type: Application
    Filed: October 18, 2011
    Publication date: February 9, 2012
    Applicant: COLORADO SCHOOL OF MINES
    Inventors: Ruth M. Tinnacher, Bruce D. Honeyman
  • Publication number: 20110312097
    Abstract: Gel for radiation dosimeter including a gel part (A) and a gel part (B) that become cloudy when exposed to a fixed dose or more, wherein said gel part (A) exposed to more than a specified dose above the fixed dose maintains a cloudy state regardless of the decrease in external temperature; and said gel part (B) exposed to less than the specified dose above the fixed dose changes gradually from a cloudy state into a transparent state according to the decrease in external temperature.
    Type: Application
    Filed: June 15, 2011
    Publication date: December 22, 2011
    Inventors: Akihiro HIROKI, Naotsugu Nagasawa, Masao Tamada, Takuji Kojima, Yuichi Sato, Akio Ohta, Hisamichi Yamabayashi, Takayoshi Yamamoto
  • Patent number: 8026100
    Abstract: The present teachings are directed toward methods of determining the lifetime of a catalyst for producing carbon nanotubes. The methods include providing different isotopically-labeled reaction components, primarily hydrocarbon sources containing different carbon isotopes, to the catalyst and measuring the Raman spectra of the carbon nanotubes produced with the different hydrocarbon sources.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: September 27, 2011
    Assignee: Honda Motor Co., Ltd.
    Inventors: Elena Mora, Avetik Harutyunyan
  • Patent number: 8008083
    Abstract: The present invention discloses a method for diagnosing a cardiac complication in a patient due to coronary catheterization, comprising the steps of (a) obtaining at least one baseline sample from the patient during or after coronary catheterization, and then (b) obtaining at least one test sample from the patient after coronary catheterization, (c) determining a change of the level of an ANP-type peptide between the baseline sample and the test sample, wherein a significant decrease in the level of the ANP-type peptide according to step c) indicates a cardiac complication.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: August 30, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Georg Hess, Andrea Horsch, Dietmar Zdunek
  • Patent number: 7985589
    Abstract: The invention provides a calibrating method for use in a method of determining the quantity of an analyte labeled with an accelerator mass spectrometry (AMS) isotope in a test sample. The samples can include, for example, urine, faeces, plasma or blood. The analyte can be, for example, a drug or metabolite of a drug.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: July 26, 2011
    Assignee: Xceleron, Limited
    Inventors: Ronald Colin Garner, Graham John Lappin
  • Patent number: 7976780
    Abstract: Methods and apparatus are provided to measure isotopic characteristics of a number of sample types. Embodiments of the invention combine novel and existing components to produce more accurate isotopic information. Further, embodiments of the invention allow for isotopic readings to be taken and analyzed outside of a laboratory. An example of such an embodiment is an apparatus comprising a combustion furnace; a reactant tube passing through the combustion furnace; an injector coupled to one, or a combination of, the combustion furnace, and reactant tube, to introduce a sample; a laser isotopic measurement device coupled to the reactant tube on the exit end; and a processor electrically coupled to one, or a combination of, the injector, the combustion furnace, the reactant tube, and the isotopic measurement device, in which a carrier gas transports the sample through the apparatus.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: July 12, 2011
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Louis W. Elrod, Christopher M. Jones
  • Patent number: 7951345
    Abstract: The present invention provides new and useful features and mechanisms for the localization and transport of biopsy specimens. The invention having a specimen board, an absorbent material in operative engagement and in coplanar alignment with the specimen board, a compression sheet, radio opaque indicia located within the specimen board, and a flexible connection between the compression sheet and the specimen board, and an attachment device which provides for removable engagement of the specimen board and compression sheet. The apparatus further provides for a clear visualization window and operating instructions. The absorbent material is capable of adjustable movement between a first and second position, providing orthogonal positioning relative to the specimen board. As a result, the apparatus may be used to create three dimensional radiographic images allowing tissue analysis resulting in orthogonal views while maintaining original positional reference points.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: May 31, 2011
    Assignee: Lary Research & Development, LLC
    Inventors: Todd P. Lary, Banning Gray Lary
  • Publication number: 20110101239
    Abstract: An airborne the multi-spectral lidar instrument emits and/or detects radiation from target vegetation to assess the condition of the foliage. Time of flight analysis at multiple wavelengths permits three dimensional measurements to discriminate material at different heights, from ground to top of canopy. Radiation at 531 nm (emission and detection, vertically resolved) is used to measure de-epoxidation of the xanthophyll pigments (used for PRI), and also for stimulation of fluorescence. Radiation at 550 and/or 570 or 571 nm (emission and detection, vertically resolved) serves as a reference waveband unaffected by the de-epoxidation (used for PRI). Radiation at 690 and 740 nm (Detection only, no height resolution) or other lines for chlorophyll fluorescence, optionally using Fraunhofer/Oxygen wavelength windows and/or time gating to improve SNR. Wavelengths of 860 and 1200 nm, or similar (emission and detection, vertically resolved) are applied to measurement of water absorption and estimation of NDWI.
    Type: Application
    Filed: May 8, 2009
    Publication date: May 5, 2011
    Inventors: Iain Woodhouse, Caroline Nichol, Genevieve Patenaude, Timothy John Malthus
  • Publication number: 20110097706
    Abstract: The invention relates to a micro-reactor for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor shows a first channel formed between two layers for containing the fluid, with an inlet and an outlet, the two layers separated by a first distance. A likewise second channel with an inlet and an outlet is placed adjacent to the first channel. A gap connects the first channel and the second channel, at the gap at least one layer showing a window transparent to the method of inspection and at the window the two layers being separated by a very small distance of, for example, 1 ?m or less. The micro-reactor may be used with an optical microscope (in which all particles are in focus), inspection with a Scanning Transmission Electron Microscope (in which the range of the electrons is limited), inspection with soft X-rays in the 250-500 eV range (also showing a limited range), etc.
    Type: Application
    Filed: October 26, 2010
    Publication date: April 28, 2011
    Applicants: FEI COMPANY, STICHTING HET NEDERLANDS KANKER INSTITUUT
    Inventors: Gerard Anne Nicolaas van Veen, Jacobus Peter Johannes Peters, Pleun Dona, Alan Frank De Jong
  • Publication number: 20110092806
    Abstract: The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.
    Type: Application
    Filed: October 9, 2006
    Publication date: April 21, 2011
    Applicant: GUEREBET
    Inventors: Marc Port, Claire Corot, Thierry Gautheret
  • Publication number: 20110091980
    Abstract: A diagnostic method using biomarkers to predict future adverse coronary events is provided. More particularly, the present invention is directed to diagnostic tests for characterizing an individual's risk of developing or having cardiovascular disease. In certain embodiments, the method of the present invention quantitates the presence of elevated levels of chlorinated lipids derived from myeloperoxidase as a prognostic indicator of future adverse coronary events.
    Type: Application
    Filed: October 16, 2009
    Publication date: April 21, 2011
    Applicant: SAINT LOUIS UNIVERSITY
    Inventor: David A. Ford
  • Publication number: 20110081724
    Abstract: The present invention relates to devices, systems, and methods for determination of ionizing radiation. In some embodiments, the devices comprise nanocomposite materials containing nanostructures (e.g., carbon nanotubes) dispersed in radiation sensitive polymers. In some cases, the device may include a conductive pathway that may be affected upon exposure to ionizing radiation. Embodiments described herein may provide inexpensive, large area, low power, and highly sensitive radiation detection materials/devices.
    Type: Application
    Filed: October 6, 2010
    Publication date: April 7, 2011
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Jose M. Lobez
  • Patent number: 7879545
    Abstract: A classifier to predict cellular radiation sensitivity based on gene expression profiles in thirty-five cell lines from the NCI panel of 60 cancer cell lines (NCI-60), using a novel approach to predictive gene analysis. Three novel genes are provided, retinoblastoma binding protein 4 (RbAp48), G-protein signaling regulator 19 (RGS19) and ribose-5-phosphate isomerase A (R5PIA) whose expression values were correlated with radiation sensitivity.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: February 1, 2011
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
    Inventors: Javier F. Torres-Roca, Timothy Yeatman, Steven Eschrich
  • Publication number: 20110008896
    Abstract: A paint that warns of radiological or chemical substances comprising a paint operatively connected to the surface, an indicator material carried by the paint that provides an indication of the radiological or chemical substances, and a thermo-activation material carried by the paint. In one embodiment, a method of warning of radiological or chemical substances comprising the steps of painting a surface with an indicator material, and monitoring the surface for indications of the radiological or chemical substances. In another embodiment, a paint is operatively connected to a vehicle and an indicator material is carried by the paint that provides an indication of the radiological or chemical substances.
    Type: Application
    Filed: July 16, 2010
    Publication date: January 13, 2011
    Inventors: Joseph C. Farmer, James L. Brunk, S. Daniel Day
  • Patent number: 7863047
    Abstract: New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: January 4, 2011
    Assignee: Provectus Pharmatech, Inc.
    Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
  • Patent number: 7858374
    Abstract: A method and device for reducing positron emitter isotope labeled CO2 to positron emitter isotope labeled CO generally includes introducing a volume of positron emitter isotope labeled CO2 into a first heated reaction vessel comprising a metal oxide, such as Iron (II) Oxide such that the CO2 is reduced to CO upon contact with the Iron (II) Oxide. The volume is then transferred to a second reaction vessel to remove any un-reacted CO2, preferably, via a soda-lime trap. The volume is then transferred to a target, e.g., a storage vessel or subject. The CO2 includes one of [11C] or [15O]. The first reaction vessel is, preferably, heated to a temperature of between 900 and 1000° C., and more preferably, to between 925 and 975° C., and even more preferably, to approximately 950° C. Preferably, the Iron (II) Oxide powdered and has a particle size of about ?10 mesh.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: December 28, 2010
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Charles Russell Buchanan, Andrew C. Williamson