Clotting Or Clotting Factor Level Tests Patents (Class 436/69)
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Patent number: 12203947Abstract: The present invention is directed to devices having a substance receiving portion and a membrane constituting the bottom of the substance receiving portion and having such a structure as to allow fluid disposed in the substance receiving portion to be transferred therefrom through the membrane when a vacuum force is applied to the bottom of the substance receiving portion for the purpose of an in-situ preparation of a sample to detect the presence and/or quantify of clottable fibrinogen. The present invention is also directed to corresponding methods, processes and systems.Type: GrantFiled: May 12, 2021Date of Patent: January 21, 2025Assignee: Omrix Biopharmaceuticals Ltd.Inventors: Elena Grimberg, Roberto Meidler, Yonit Tiberman, Nadav Orr, Nadav Ashkenazy
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Patent number: 12072310Abstract: As one example, an apparatus includes a dielectric microsensor having a microfluidic chamber that includes a capacitive sensing structure. The microfluidic chamber is adapted to receive a volume of a blood sample, and a bioactive agent is adapted to interact with the blood sample, as a sample under test (SUT), within the microfluidic chamber. A transmitter can provide an input radio frequency (RF) signal to the dielectric microsensor, and a receiver can receive an output RF signal from the dielectric microsensor. A computing device is configured to compute dielectric permittivity values for the SUT based on the output RF signal over a time interval in which the dielectric permittivity values are representative of the bioactive agent interacting with the blood sample over the time interval. The computing device is further configured to provide a readout representative of hemostatic dysfunction for the blood sample based on the dielectric permittivity values.Type: GrantFiled: August 21, 2023Date of Patent: August 27, 2024Assignees: CASE WESTERN RESERVE UNIVERSITY, UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTERInventors: Pedram Mohseni, Lalitha Nayak, Michael Suster, Sina Pourang
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Patent number: 11465146Abstract: A system, mixing-enhanced microfluidic container, and methods for small volume sample collection and/or analysis is disclosed. Namely, the invention is directed to a small volume sample collection system that includes a mixing-enhanced microfluidic container and a durable reusable actuation chuck. The mixing-enhanced microfluidic container is used to collect small volumes of sample fluid and includes a means for mixing the sample fluid with reagents disposed within the microfluidic container. The mixing means utilize an array of surface-attached structures (e.g., a micropost array). The application of an “actuation force,” such as a magnetic or electric field, actuates the surface-attached structures into movement, wherein the actuation chuck in close proximity to the mixing-enhanced microfluidic container provides the “actuation force.Type: GrantFiled: November 17, 2017Date of Patent: October 11, 2022Assignees: Redbud Labs, Inc., The University of North Carolina at Chapel HillInventors: Richard Chasen Spero, Jay Kenneth Fisher, Richard Superfine
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Patent number: 11435374Abstract: A sample collection and testing device for analyzing blood is provided that includes a controller, a fluid flow pathway, a pump configured to move fluid through the fluid pathway, and an optical fluid measurement element configured to measure a light intensity of the fluid in the fluid flow pathway. The controller is configured to: start the pump to move a blood sample in the fluid flow pathway, receive a signal from the optical fluid measurement element indicating a detection of a leading edge of the blood in the fluid flow pathway, stop the pump to stop the moving of the blood in the pathway, receive a plurality of light intensity measurements from the optical measurement element, each light intensity measurement measured at a corresponding point of time, and provide a mapping of the light intensity measurements into an indication of a coagulation of the blood sample over a time period.Type: GrantFiled: November 8, 2021Date of Patent: September 6, 2022Assignee: 2Pi-Sigma Corp.Inventor: Mehdi Hatamian
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Patent number: 11378508Abstract: The measuring device for viscometric analysis on a biological fluid, comprises a base frame and a support element associated with the base frame, having an elongated shape and with: a first ending part associable with motor means to set in rotation the support element around an axis of rotation (A); a second ending part opposite to the first ending pan and positionable in contact with a fluid to be analyzed contained in a collecting vessel; sensor means adapted to measure the viscosity values of the fluid; wherein the sensor means comprise a first sensor element and a second sensor element associated with the support element and operable in rotation around the axis of rotation (A) at a predefined rotational speed, and operatively connected to optical means adapted to detect a speed change between the sensor means depending on said viscosity values.Type: GrantFiled: September 6, 2017Date of Patent: July 5, 2022Assignee: Viscop S.r.l.Inventors: Marco Ranucci, Francesco Napolitano, Franco Scorziello
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Patent number: 11360074Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.Type: GrantFiled: May 27, 2020Date of Patent: June 14, 2022Assignee: Coagulation Sciences LLCInventors: Sheldon Goldstein, Michael Kagan, Nicholas Lauder, Maury D. Cosman
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Patent number: 11166659Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component which is homeostatically present in blood, the kit including a diluent solution for diluting the blood sample, a first storing instrument for storing the diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the separation instrument is composed of glass fiber coated with a resin.Type: GrantFiled: June 27, 2019Date of Patent: November 9, 2021Assignee: FUJIFILM CorporationInventors: Hikaru Urano, Shinya Sugimoto, Isao Yonekubo
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Patent number: 11022558Abstract: The present invention discloses a coagulation analyzer and a coagulation analysis method which relate to the technical field of medical instruments. The coagulation analyzer includes an optical coagulation analysis module, a sample interference analysis module, a magnetic coagulation analysis module, and a test transfer module. The coagulation analyzer uses the sample interference analysis module to determine whether an interferent in the sample has effect on the coagulation test result of the optical coagulation analysis module. If the interferent in the sample has no effect on the coagulation test result, the optical coagulation analysis module is used to perform the coagulation analysis and report the test result. If the interferent in the sample has effect on the coagulation test result, the test transfer module is used to transfer the test to the magnetic coagulation analysis module to perform the coagulation analysis and report the test result.Type: GrantFiled: May 30, 2018Date of Patent: June 1, 2021Assignee: SHENZHEN THISTORY BIO-MEDICAL CO., LTDInventor: Lihua Zhang
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Patent number: 10983107Abstract: Systems and methods to analyze blood or other fluid sample. The systems and methods utilize bi-directional magnetic forces to push or pull a magnetic object along a post in a chamber housing the fluid sample both before and after clot initiation has been implicated. The magnetic object can be threadably connected to the post. In other embodiments, the chamber is configured such that the magnetic object does not rotate but only slides along the post. Once a clot has been detected, the washer can be moved either up or down to apply either compressive force or strain within the clot, as desired, to evaluate elastic properties or firmness of the clot.Type: GrantFiled: August 23, 2018Date of Patent: April 20, 2021Assignee: Medtronic Vascular, Inc.Inventors: Trevor Huang, Charlene Yuan, Tessy Kanayinkal
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Patent number: 10746750Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.Type: GrantFiled: September 28, 2018Date of Patent: August 18, 2020Assignee: C A Casyso GmbHInventors: Axel Schubert, Jose J. Romero-Galeano, Max Kessler
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Patent number: 10739360Abstract: Disclosed is an analyzing method, for analyzing a blood specimen, which includes: mixing a blood specimen and a thrombin-containing reagent to coagulate the blood specimen, and obtaining a coagulation waveform; obtaining a value of a parameter concerning differentiation of the coagulation waveform, based on the coagulation waveform; and obtaining information concerning an amount of antigen of fibrinogen based on the obtained value of the parameter.Type: GrantFiled: April 19, 2018Date of Patent: August 11, 2020Assignees: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SYSMEX CORPORATIONInventors: Atsuo Suzuki, Tadashi Matsushita, Sho Shinohara, Nobuo Arai
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Patent number: 10613077Abstract: Aspects of the disclosure relate to clotting time tests detect clotting time based on the viscosity changes of a fluid sample, using a disk dropped within a test chamber containing the fluid sample from a disk maximal position to a disk minimal position, which is a point at which the disk settles within the fluid sample. Changes in the disk minimal position as multiple test cycles are conducted are used in assessing formation of a clot within the fluid sample. Methods of assessing such changes in the disk minimal position are disclosed.Type: GrantFiled: September 14, 2017Date of Patent: April 7, 2020Assignee: Medtronic Vascular, Inc.Inventors: Charlene Yuan, Lawrence Erickson, Trevor Huang
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Patent number: 10518260Abstract: The invention pertains to a device for separation of serum or plasma from blood cells without application of an external force, such as centrifugation or pressure. The device comprises a hollow body having a top open end and a bottom end comprising a porous membrane. Particularly, the pore size of the porous membrane is between 10 nm and 20 ?m. The invention also pertains to methods of separating serum or plasma from blood cells, the methods comprising introducing into the device a mixture of serum or plasma and blood cells and incubating the device in a substantially vertical position for between about one minute and thirty minutes to allow the separation of serum or plasma from blood cells under gravity.Type: GrantFiled: May 24, 2019Date of Patent: December 31, 2019Assignee: NANO DISCOVERY, INC.Inventor: Tianyu Zheng
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Patent number: 10488424Abstract: A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. The analytical membrane (14) includes a porous hydrophilic sample portion (34), a porous hydrophilic analytical portion (36), and a porous hydrophilic wicking portion (38). The porosity of the analytical portion (36) differs from the porosity of the sample portion (34). The method utilizes the device to analyze blood coagulation in a whole blood sample from the distance travelled by the red blood cell leading edge (50) in a predetermined period of time.Type: GrantFiled: March 3, 2015Date of Patent: November 26, 2019Assignee: University of CincinnatiInventors: Andrew J. Steckl, Giovanni M. Pauletti, Hua Li
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Patent number: 10267817Abstract: Provided is an automatic analysis apparatus for inspecting blood coagulation, which is capable of miniaturizing device configuration and reducing device costs. The automatic analysis apparatus includes: a reaction container in which a specimen and a reagent are mixed with each other and the mixed solution is reacted; a sample dispensing mechanism which dispenses the specimen into the reaction container; a blood coagulation time measuring unit in which the reaction container is mounted to measure a coagulation time of the mixed solution within the reaction container; a reaction container accommodating unit which accommodates a plurality of reaction containers provided to the blood coagulation measuring unit; a reaction container transfer mechanism which grasps the reaction container and transfers the reaction container to the blood coagulation measuring unit; and a control unit which controls the reaction container transfer mechanism.Type: GrantFiled: June 10, 2015Date of Patent: April 23, 2019Assignee: Hitachi High-Technologies CorporationInventors: Tatsuya Sakai, Akihisa Makino, Minoru Sano, Chie Yabutani
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Patent number: 10215766Abstract: Disclosed is a blood sample determination method including: emitting light to a measurement specimen prepared by mixing a clotting time measuring reagent and a blood sample suspected to be derived from a subject having lupus anticoagulant or a coagulation factor inhibitor, to obtain optical information about an amount of light from the measurement specimen; obtaining at least one parameter regarding derivative of clot waveform, based on the obtained optical information; and determining, based on a value of the obtained parameter, whether the blood sample is suspected to be a sample derived from a subject having lupus anticoagulant or is suspected to be a sample derived from a subject having a coagulation factor inhibitor.Type: GrantFiled: December 15, 2015Date of Patent: February 26, 2019Assignees: PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY, SYSMEX CORPORATIONInventors: Midori Shima, Keiji Nogami, Yuka Tabuchi, Hiroshi Kurono
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Patent number: 9927425Abstract: The present invention relates to an apparatus and method for testing a multi-function and a drug response of platelet based on a centrifugal microfluidics. The testing apparatus according to the present invention may include: a rotatable disk; a sample chamber arranged at the center of the disk such that a blood sample is accommodated therein; stirring chambers respectively connected to the sample chamber in multiple radial directions so as to introduce a shear flow in the blood sample; microchannels connected to the stirring chambers such that adhesion and cohesion of platelets occur during the movement of the blood sample; and a waste sample chamber in which the blood sample is accommodated after passing through the microchannels. According to the present invention, multiple drug tests can be performed on a single blood sample at one time in multiple channels such that multiple tests is possible with respect to complex platelet functions, and thus testing time is reduced and testing costs can be saved.Type: GrantFiled: December 27, 2013Date of Patent: March 27, 2018Assignee: Korea University Research and Business FoundationInventors: Se Hyun Shin, Chae Seung Lim, Jeong Hoon Nam, Hyun Jung Lim
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Patent number: 9518997Abstract: A blood coagulation system analysis device capable of analyzing a blood coagulation system with high accuracy, and a method and a program for analysis of a blood coagulation system are proposed. The blood coagulation system is observed as a temporal change in permittivity before the viscoelasticity manifestation timing (timing at which blood starts to clot from the viewpoint of viscoelasticity (in greater detail, timing at which active polymerization of fibrin monomers starts)). A permittivity of blood which is positioned between a pair of electrodes is measured at predetermined time intervals after the anticoagulant effect acting on the blood is ended, and from the measurement result, a degree of the action of the blood coagulation system is analyzed.Type: GrantFiled: January 7, 2010Date of Patent: December 13, 2016Assignee: SONY CORPORATIONInventor: Yoshihito Hayashi
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Patent number: 9291612Abstract: In some examples, a device applies an electrical potential difference across a blood sample. The device measures an electrical signal that passes through the blood sample over a duration of time to obtain a plurality of measurements representing a measurement function of time. An accumulative property of the measurement function may be determined such that the accumulative property correlates to a blood coagulation characteristic.Type: GrantFiled: October 1, 2012Date of Patent: March 22, 2016Assignee: Micropoint Bioscience, Inc.Inventors: Pingyi Yan, Haitao Huang, Shenyu Wang, Huihui Lu
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Patent number: 9233126Abstract: The present invention relates to a method of treating functional disability and/or pain associated with joints, tendons or connective tissue diseases, disorders or injuries comprising oral administration of a composition comprising heterologous platelet-rich plasma. The invention also relates to pharmaceutical compositions and nutritional compositions comprising heterologous platelet-rich plasma and uses thereof.Type: GrantFiled: February 13, 2013Date of Patent: January 12, 2016Assignee: OPKO LAB EUROPE SLInventors: Julian Agut Sanchez, Carlos Fernandez Navarro, Joan Cos Trullas, Laura Ocana Safont, Elsa Genove Corominas
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Patent number: 9233145Abstract: The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.Type: GrantFiled: March 11, 2013Date of Patent: January 12, 2016Assignee: Biogen Hemophila Inc.Inventors: Glenn Pierce, Samantha Truex, Robert T. Peters, Haiyan Jiang
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Patent number: 9205424Abstract: The invention lies in the field of platelet function diagnostics and relates to devices and methods for determining the platelet function in a centrifugal analyzer.Type: GrantFiled: March 15, 2012Date of Patent: December 8, 2015Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBHInventors: Joerg Endermann, Andreas Rechner, Norbert Zander
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Patent number: 9182416Abstract: A method of monitoring thrombus formation is described, which comprises flowing anticoagulated blood into a thrombus formation chamber, in at least a part of which a thrombus formation inducer inducing thrombus formation is provided, while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation in the thrombus formation chamber.Type: GrantFiled: December 17, 2012Date of Patent: November 10, 2015Assignee: FUJIMORI KOGYO CO., LTD.Inventor: Kazuya Hosokawa
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Patent number: 9075046Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: GrantFiled: November 24, 2009Date of Patent: July 7, 2015Assignee: Theranos, Inc.Inventors: Timothy M. Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton
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Patent number: 9052258Abstract: The invention is in the field of coagulation diagnostics and relates to in vitro methods for determining thrombocyte function using measuring cells, particularly measuring cells of the PFA system. The methods make it possible to obtain standardized measured results which are comparable, irrespective of the type of measuring cell used.Type: GrantFiled: July 5, 2012Date of Patent: June 9, 2015Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBHInventor: Andreas Rechner
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Patent number: 9046512Abstract: Apparatus (1) for determining a property of a sample. The apparatus has a chamber (11, 13) for receiving at least a part of the sample and contains a rotor (15) adapted to rotate within the chamber (11, 13). The apparatus (1) also has a space (17) between the rotor (15) and the chamber (11, 13) which may be at least partially occupied by the sample, driving means (14) for rotating the rotor (15), and a detector (39) arranged to detect the rate of rotation of the rotor (15). The apparatus may also have two parts, a sample strip (5) for receiving the sample and a receiving member (3) for receiving the sample strip (5) and carrying out measurements on the sample. The rotor (15) may be magnetized across its diameter. The driving means (14) may be a magnetic driving means. The sample may be a blood sample. The property to be determined by the sample may be the prothrombin time of the blood or plasma.Type: GrantFiled: July 11, 2011Date of Patent: June 2, 2015Assignee: BIO AMD HOLDINGS LIMITEDInventors: Nasser Djennati, Andrew Mitchell
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Publication number: 20150140671Abstract: A microfluidic sensor (10), such as an electrochemical blood test strip, with more accurate measurement comprises a plurality of channels (24) through which a fluid to be tested flows via a capillary action. One or more electrodes (30) are located under the channels (24). As the fluid flows over the electrodes (30) in the channels (24), the impedance between the electrodes (30) may be measured to determine fluid properties. In order to increase the accuracy of the measurements, the electrode deposition may be configured to be less than 10 ?m in thickness via a printing process with high process consistency, thereby reducing the disruption of the electrode deposition on the fluid flow.Type: ApplicationFiled: November 18, 2013Publication date: May 21, 2015Applicant: JOHNSON ELECTRIC S.A.Inventor: Libing Zhang
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Publication number: 20150140560Abstract: The disclosure provides a label-free viscosity-based analyte detection system using paramagnetic beads as an asynchronous magnetic bead rotation (AMBR) microviscometer. It is disclosed herein that the bead rotation period is linearly proportional to the viscosity of a solution comprising analytes surrounding the paramagnetic bead. Optical measurement of asynchronous microbead motion determines solution viscosity precisely in microscale volumes, thus allowing an estimate of analyte concentration. The results demonstrate the feasibility of viscosity-based analyte detection using AMBR in microscale aqueous volumes.Type: ApplicationFiled: November 4, 2014Publication date: May 21, 2015Inventors: Raoul Kopelman, Mark A. Burns, Yunzi Li
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Patent number: 9034264Abstract: The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.Type: GrantFiled: August 22, 2014Date of Patent: May 19, 2015Assignee: Highland Biosciences LimitedInventor: Richard Day
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Patent number: 8999242Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes.Type: GrantFiled: November 27, 2013Date of Patent: April 7, 2015Assignee: AgaMatrix, Inc.Inventors: Ian Harding, Sridhar G. Iyengar, Ha Nguyen, Richard Williams, Anoop Rao
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Patent number: 8999243Abstract: A blood coagulation analysis device and method in which information relating to the coagulability of blood is evaluated based on a change generated in a permittivity measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.Type: GrantFiled: March 7, 2014Date of Patent: April 7, 2015Assignee: Sony CorporationInventors: Yoshihito Hayashi, MarcAurele Brun, Shinji Omori, Yoichi Katsumoto, Kazumasa Sato
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Publication number: 20150093771Abstract: An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. The liquid processing unit comprises a mixing chamber for mixing a sample with a reagent, a sample dosing chamber for delivering a defined volume of the sample to the mixing chamber, and a reagent channel for delivering the reagent to be mixed with the sample, wherein the mixing chamber also serves as a detection chamber.Type: ApplicationFiled: December 2, 2014Publication date: April 2, 2015Inventors: Patrick Griss, Rainer Jaeggi, Goran Savatic, Vuk Siljegovic
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Patent number: 8974732Abstract: A method for determining the area of an analysis chamber covered by a biologic fluid sample quiescently residing within the chamber is provided. The chamber has a first panel with an interior surface, and a second panel with an interior surface, both of which panels are transparent.Type: GrantFiled: December 3, 2012Date of Patent: March 10, 2015Assignee: Abbott Point of Care, Inc.Inventors: Niten V. Lalpuria, Stephen C. Wardlaw
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Publication number: 20150064732Abstract: An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.Type: ApplicationFiled: February 28, 2014Publication date: March 5, 2015Inventor: Kee Van Sin
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Patent number: 8921115Abstract: The invention includes systems, apparatuses and methods to evaluate the strength of clotting in addition to or separate from activated clotting time. The strength of clotting may be correlated with the amount of energy employed to move an object within blood. The strength of clotting may be correlated with the amount of time for fibrinolysis to occur. The strength of clotting may be determined by a system in which a ferromagnetic material is moved within blood.Type: GrantFiled: March 7, 2013Date of Patent: December 30, 2014Assignee: Medtronic, Inc.Inventors: Charlene Yuan, Trevor Huang
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Patent number: 8900872Abstract: A method is provided for adjusting either the signal measured or activity calculated by an instrument or a predefined calibration curve for a medical diagnostic test, performed on an instrument with pre-calibrated reagents. A calibration adjuster for a blood clotting diagnostic test is further provided.Type: GrantFiled: October 2, 2008Date of Patent: December 2, 2014Assignee: Diagnostica StagoInventors: Frederic Esteve, Lydie Nicoud
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Patent number: 8883510Abstract: The invention relates to a method for determining haemostasis parameters by measuring vibration parameters of a resonator having a measuring surface which contacts a platelet containing sample fluid. The invention is characterized by the analysis of the characteristic of a vibration parameter over time, based on which the platelet function will then be assessed and a distinction will be made between the presence of an adhesion disorder or that of an aggregation disorder.Type: GrantFiled: September 9, 2010Date of Patent: November 11, 2014Assignee: Andreas Hettich GmbH & Co. KGInventors: Frank K. Gehring, Hans Wendel, Stefan Sinn, Lothar Mueller
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Patent number: 8877510Abstract: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable to the cell such that one end of the at least one electrode wire pair forms a sensor unit for measuring the electrical impedance between the two electrode wires of the at least one electrode wire pair within the blood sample and that the opposite end of the at least one electrode wire pair forms a plug portion being connectable directly to the plug for an electrical connection of the sensor unit to an analyzer.Type: GrantFiled: November 22, 2013Date of Patent: November 4, 2014Assignee: F. Hoffmann-La Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Publication number: 20140323573Abstract: The present invention proposes novel salt compounds for use in the diagnosis or therapy of a patient as well as drugs, medical products, diagnostic compositions or blood products containing a salt compound according to the invention. The salt compounds according to the invention comprise the cation of a metabolisable basic amino acid and the anion of a metabolisable carboxylic acid or an anion of carbonic acid. Those salt compounds therefore have the advantage that they are fully metabolisable and thus do not adversely affect the electrolyte balance or the acid-base balance of the patient.Type: ApplicationFiled: November 30, 2012Publication date: October 30, 2014Inventor: Manfred Rüdinger
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Patent number: 8857244Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.Type: GrantFiled: May 15, 2013Date of Patent: October 14, 2014Assignee: C A Casyso AGInventors: Axel Schubert, José Javier Romero-Galeano, Max Kessler
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Publication number: 20140295472Abstract: A device utilizing agglutination and its method of use to diagnose diseases or conditions. The diagnostic device may comprise a substrate having pores, an agglutination zone, and a test readout zone wherein said agglutination zone is functionalized with an agglutinating agent to cause agglutination of the sample.Type: ApplicationFiled: November 13, 2012Publication date: October 2, 2014Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventors: Sergey S. Shevkoplyas, Xiaoxi Yang, Julie Kanter Washko, Nathaniel Zane Piety
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Patent number: 8845968Abstract: The present application provides apparatus (300, 400) and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator (108, 109, 110). Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.Type: GrantFiled: December 27, 2007Date of Patent: September 30, 2014Assignee: Highland Biosciences LimitedInventor: Richard Day
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Publication number: 20140273249Abstract: High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. The cartridge is treated with a strong surface treatment process, such as an atmospheric plasma treatment, to increase the hydrophilic property of the test chamber, there may be a significant reduction in the kaolin concentration required to activate the blood sample and initiate the coagulation process. The kaolin concentration may be further reduced if the buffer component used in the buffer saline contains phosphate. The reduction of the kaolin concentration allows more calcium to be released from the kaolin to participate in the clotting process. The combined effect of adding a surface treatment to the cartridge to increase the hydrophilic property of reaction chamber and adding phosphate into buffered saline allows for clot detection of blood samples containing 5˜6 U/mL heparin.Type: ApplicationFiled: March 12, 2013Publication date: September 18, 2014Applicant: MEDTRONIC, INC.Inventors: Charlene Yuan, Trevor C. Huang, Tessy Kanayinkal, Mary Jo Passenheim, Craig D. Petersen, Ivan Akunovich
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Publication number: 20140256052Abstract: The invention includes systems, apparatuses and methods to evaluate the strength of clotting in addition to or separate from activated clotting time. The strength of clotting may be correlated with the amount of energy employed to move an object within blood. The strength of clotting may be correlated with the amount of time for fibrinolysis to occur. The strength of clotting may be determined by a system in which a ferromagnetic material is moved within blood.Type: ApplicationFiled: March 7, 2013Publication date: September 11, 2014Applicant: Medtronic, Inc.Inventors: Charlene Yuan, Trevor Huang
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Patent number: 8828676Abstract: The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.Type: GrantFiled: October 26, 2011Date of Patent: September 9, 2014Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Alfred Weber, Peter Turecek, Hans-Peter Schwarz
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Publication number: 20140242707Abstract: The present invention provides a method for diagnosing hypercoagulability associated with carbon monoxide exposure in a subject. The method comprises obtaining a plasma sample from the subject, dividing the sample into at least two portions, and determining the clot strength of the first portion. The method further comprises exposing the second portion to an organic reductant, determining the clot strength of the second portion after exposure to the organic reductant, and comparing the clot strength of the first portion with the clot strength of the second portion. A diagnosis of hypercogulability associated with carbon monoxide exposure is made when the clot strength of the second portion is decreased compared with the cloth strength of the first portion.Type: ApplicationFiled: July 19, 2012Publication date: August 28, 2014Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Vance G. Nielsen, Keith Vosseller
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Publication number: 20140236494Abstract: Apparatus, systems, and methods are provided for assessing clot activity in blood under various conditions in vitro. The apparatus includes a plurality of test receptacles that receive the blood, at least one flow generating mechanism in communication with the test receptacles, and a clot detector configured to analyze an amount of clot formation that occurs within the blood in each receptacle. Blood contacting surfaces of a first subset of the test receptacles are coated with a first surface substrate and blood contacting surfaces of a second subset of the test receptacles are coated with a different second surface substrate. The flow generating mechanism is configured to generate a first blood flow rate through a third subset of the test receptacles and to generate a different second blood flow rate through a fourth subset of the test receptacles.Type: ApplicationFiled: May 1, 2014Publication date: August 21, 2014Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Kumaran Kolandaivelu, Elazer R. Edelman
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Patent number: 8796031Abstract: A microchip for measuring platelet function by allowing blood to flow through a channel to induce platelet aggregation, wherein the microchip has a channel provided inside thereof, wherein at least a part of the channel is coated with collagen for allowing adhesion of platelets; a plurality of walls extend along the direction of the flow of blood in the channel and divide the width of the channel to form a channel dividing section; and the walls are treated to have a surface roughness (Ra) of 10 to 200 nm.Type: GrantFiled: February 10, 2011Date of Patent: August 5, 2014Assignee: Fujimori Kogyo Co., Ltd.Inventors: Kazuya Hosokawa, Tomoko Wada, Masashi Fukasawa, Taro Kondo, Maki Terada
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Patent number: 8790885Abstract: Disclosed is a technique for obtaining a coagulogen raw material which can irreversibly inactivate the activity of a coagulase while retaining the function of coagulogen in an LAL reagent, a LAL reagent contaminated by an organism-derived biologically active substance or the like, and which can be used in a reagent. An LAL reagent is heated at a predetermined temperature for a predetermined period of time to deactivate only the activity of an enzyme contained in the LAL reagent irreversibly, wherein such an activity inherent in coagulogen that coagulogen can be hydrolyzed with the activated coagulase and converted to coagulin to induce gelatinization or an agglutination reaction is retained.Type: GrantFiled: February 19, 2010Date of Patent: July 29, 2014Assignee: Kowa Company, Ltd.Inventor: Katsumi Yabusaki
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Publication number: 20140199772Abstract: Apparatus and processes for automated diagnostic testing may include cuvette dispensing, test sample dispensing, reagent dispensing, incubation, photo-optical measuring, and a control in operative communication with the cuvette dispensing unit, the test sample dispenser, the reagent dispenser, the incubation unit, and the measuring unit. A cuvette removal location, a reagent removal location, a measuring location, and a collection receptacle may be situated along a first common circular arc having first geometric center. A cuvette-moving arm and a reagent-dispensing arm have a common axis of rotation passing through this geometric center. A sampling position, a sample dispensing position, an additional rinsing position, and an additional washing position, may all be provided on a second circular arc having second geometric center that has a second axis of rotation for a rotatable sampling arm of the test sample dispenser.Type: ApplicationFiled: March 14, 2014Publication date: July 17, 2014Applicant: DIAGON Kft.Inventors: Levente Kiss, Kornel Nagy, Matyas Petoe, Laszlo Izsak, Jozsef Antal