Optical Property Patents (Class 436/805)
  • Patent number: 9034657
    Abstract: A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location; allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location; and, after a predetermined period of time, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and which is dried on the lateral flow matrix at a location upstream of the sample port delivery of the sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species and bind with any IgE antibody bound to the immobilized IgE antigen species, a
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: May 19, 2015
    Assignee: Phadia AB
    Inventors: Gerd Rundström, Per Matsson, Paul Christopher
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Patent number: 9023281
    Abstract: Chemical indicator apparatuses containing one or more chemical indicators for use in monitoring the quality of water in an aquatic environment. The apparatuses are designed and configured to be submersible in the water that is being monitored. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo a physical change as levels of one or more constituents of the water change. Such indicators can be read by one or more suitable optical readers. These and other embodiments are designed and configured to be movable by a corresponding monitoring/measuring apparatus, for example, via a magnetically coupled drive. Also disclosed are a variety of features that can be used to provide a chemical indicator apparatus with additional functionalities.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: May 5, 2015
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 9005989
    Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: April 14, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: James Douglas Harper, Richard Hart Mathews, Bernadette Johnson, Martha Susan Petrovick, Ann Rundell, Frances Ellen Nargi, Timothy Stephens, Linda Marie Mendenhall, Mark Alexander Hollis, Albert M. Young, Todd H. Rider, Eric David Schwoebel, Trina Rae Vian
  • Patent number: 8999264
    Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 7, 2015
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael J. Pugia
  • Patent number: 8992860
    Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 31, 2015
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
  • Patent number: 8987003
    Abstract: A biosensor device (100) for detecting biological particles, the biosensor device (100) comprising an electromagnetic radiation transmitting member (102) adapted for transmitting electromagnetic radiation and a plurality of sensor active structures (104) arranged at the electromagnetic radiation transmitting member (102), wherein each of the plurality of sensor active structures (104) is sensitive to specific biological particles and is adapted to modify electromagnetic radiation transmission properties of the electromagnetic radiation transmitting member (102) in the event of the presence of the respective biological particles, and wherein the electromagnetic radiation transmitting member (102) is adapted for a simultaneous detection of different biological particles at different ones of the plurality of sensor active structures (104).
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: March 24, 2015
    Assignee: NXP B.V.
    Inventor: Pablo Garcia Tello
  • Patent number: 8987004
    Abstract: The present invention relates to affinity biosensing using polarization of light scattering of aggregated noble metallic nanostructures to determine concentration of an analyte in a test sample. This new sensing system utilizes the changes in polarized plasmonic scattering from nanostructures as the nanostructures aggregate due to binding of the analyte to a binding partner attached to the surface of the metallic nanostructure.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: March 24, 2015
    Assignee: University of Maryland, Baltimore County
    Inventor: Chris D. Geddes
  • Patent number: 8961898
    Abstract: The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 24, 2015
    Assignee: Tokyo Institute of Technology
    Inventors: Takasi Nisisako, Takahiro Baba
  • Patent number: 8945472
    Abstract: The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: February 3, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Josephus Arnoldus Henricus Maria Kahlman, Bart Michiels
  • Patent number: 8940549
    Abstract: The present invention aims to provide an assay reagent and an assay for accurately measuring KL-6, in particular, an assay reagent and an assay for accurately measuring KL-6 in samples containing a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor. KL-6 in samples that contain a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor can be accurately measured using an immunoassay reagent comprising a solution at a pH of 4.0 to 5.5 containing a rheumatoid factor interference inhibitor and a solution of an insoluble carrier on which anti-KL-6 antibodies are immobilized.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: January 27, 2015
    Assignees: Sekisui Medical Co., Ltd., Eidia Co., Ltd.
    Inventors: Junichi Kondou, Mitsuaki Yamamoto, Chie Kaneko
  • Patent number: 8932880
    Abstract: Method and apparatus for the quantitative determination of molecular interactions between ligands in solution and receptors immobilized on the surface of a solid transparent material coated by one or more antireflective dielectric layers, through direct measurement of the light reflected by the interface between the surface and the solution.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: January 13, 2015
    Assignee: ProXentia s.r.l.
    Inventors: Fabio Giavazzi, Matteo Salina
  • Patent number: 8921122
    Abstract: The present invention provides systems and methods for assessing migration behavior of biological particles, such as neutrophils, under the effect of a gradient. The systems can include one or more migration chambers, one or more gradient sources configured to generate particular gradients, e.g., of chemokines or the like across the width of the migration chamber, and a detection arrangement that is configured to determine spatial profiles across the migration chamber that indicate the extent of migration.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: December 30, 2014
    Assignee: The General Hospital Corporation
    Inventor: Daniel Irimia
  • Patent number: 8920749
    Abstract: A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: December 30, 2014
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Youichi Aoki, Akihisa Nakajima, Kusunoki Higashino, Yasuhiro Sando, Yoshikazu Kurihara
  • Patent number: 8920723
    Abstract: A sample support structure comprising a sample support manufactured from a semiconductor material and having one or more openings therein. Methods of making and using the sample support structure.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: December 30, 2014
    Assignee: Protochips, Inc.
    Inventors: John Damiano, Jr., Stephen E. Mick, David P. Nackashi
  • Patent number: 8906672
    Abstract: A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: December 9, 2014
    Assignee: Flir Systems, Inc.
    Inventor: John Gerard Quinn
  • Patent number: 8900515
    Abstract: The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: December 2, 2014
    Assignee: Health & Life Co., Ltd.
    Inventor: Meng Yi Lin
  • Patent number: 8900881
    Abstract: The present invention relates to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 2, 2014
    Inventor: Jin Po Lee
  • Patent number: 8883079
    Abstract: A water-quality monitoring system for an aquatic environment that includes a monitoring unit and a chemical indicator wheel designed and configured to be submerged in the water being monitored. The chemical indicator wheel includes a holder that supports a number of chemical indicators selected for use in measuring levels of constituents of the water. When in use, the wheel is drivingly engaged with a monitoring/measuring unit that includes at least one reader for reading the chemical indicators. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo an optically detectable physical change as levels of one or more constituents of the water change. Also disclosed are a variety of features that can be used to provide the monitoring system with additional functionalities.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: November 11, 2014
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 8877519
    Abstract: A chemical sensor element contains a resonator having a first reflector in which particles of a fine metal structure are arranged two-dimensionally and periodically is counterposed with interposition of a dielectric layer to a second reflector, wherein the resonance wavelength of a resonator in which the entire of the first reflector is replaced by a metal thin film having the same thickness as the metal fine structure is different from the surface plasmon resonance wavelength induced in the metal fine structure; and the mode of the surface plasmon resonance excited in the metal fine structure is coupled with the mode of the resonator in which the entire of the first reflector is replaced by the metal thin film.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: November 4, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tomohiro Yamada, Yoichiro Handa
  • Patent number: 8865458
    Abstract: The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows through the specimen passage slot into the reservoir. Flow into the reservoir may be limited by the reservoir seal. The test device positioned within the reservoir detects the presence or concentration of an analyte within the sample or specimen.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: October 21, 2014
    Assignee: Alere Switzerland GmbH
    Inventors: James T. Ramsey, Larry Hartselle
  • Patent number: 8859204
    Abstract: A method comprises loading a sample portion into a sample chamber which comprises means for minimizing diffusion of the sample portion, subjecting the sample portion to an amplification step, and determining whether the sample portion contains at least one molecule of a target nucleic acid. If the sample portion contains a single molecule of the target nucleic acid, the sample portion would attain a detectable concentration of the target nucleic acid after a single round of amplification. Also, a microfluidic device comprising a sample portion and a sample chamber comprising means for minimizing diffusion of the sample portion. Also, a microfluidic device comprising a sample chamber and an amplification targeting reagent positioned in the first sample chamber.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: October 14, 2014
    Assignees: Applied Biosystems, LLC, The United States of America, As Represented by the Secretary, Department of Health and Human Services
    Inventors: James F. Brown, Jonathan E. Silver
  • Patent number: 8845981
    Abstract: A device for volumetric metering a liquid biologic sample is provided. The device includes an initial chamber, a second chamber, a third chamber, a first valve, a second valve and a third valve. The chambers are each configured so that liquid sample disposed in the respective chamber is subject to capillary forces. Each chamber has a volume, and the volume of the initial chamber is greater than the volume of either the second or the third chambers. The valves each have a burst pressure. The burst pressure of the first valve is greater than the third burst pressure. The first valve is in fluid communication with the second chamber. The second valve is disposed between, and is in fluid communication with, the initial chamber and the third chamber. The third valve is in fluid communication with the third chamber.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 30, 2014
    Assignee: Abbott Point of Care, Inc.
    Inventor: Manav Mehta
  • Patent number: 8841137
    Abstract: Disclosed is a product that includes an optical sensor; a target-responsive hydrogel matrix on a surface of the optical sensor (where the hydrogel matrix comprises one or more target-specific receptors and one or more target analogs), and one or more high refractive index nanoparticles within the hydrogel matrix, where a detectable change occurs in a refractive index of the hydrogel matrix when contacted with one or more target molecules. Sterile packages and detection devices containing the product, and methods of detecting a target molecule using the product, are also disclosed.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: September 23, 2014
    Assignee: University of Rochester
    Inventors: Lisa DeLouise, Lisa Bonanno
  • Patent number: 8841119
    Abstract: A method of fabricating biochip sensor comprising providing a precursor; depositing the precursor on a substrate to form a coating; and rapid melting/quenching treatment of the coating with an energy source to form micro/nanotextured surface with enhanced reflectance for fast chemiluminescence response of E-Coli bacteria.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: September 23, 2014
    Assignee: Mridangam Research Intellectual Property Trust
    Inventors: Pravansu S. Mohanty, Ramesh K. Guduru
  • Patent number: 8835185
    Abstract: A substrate of a target substance-detecting element for detecting a target substance in a specimen based on localized surface plasmon resonance comprises a supporting member and a metal nano-dot group provided on the supporting member, metal nano-dots each of which is comprised in the metal nano-dot group and adjacent to each other are arranged with a gap between the metal nano-dots of not larger than 30 nm.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: September 16, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventors: Satoru Nishiuma, Masaya Ogino
  • Patent number: 8835182
    Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: September 16, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Junichi Katada, Hideyuki Karaki, Takayoshi Oyamada
  • Patent number: 8822183
    Abstract: A device for amplifying target nucleic acid in a sample can include a planar fluidic assembly including a transparent substrate, a porous material layer on a surface of the transparent substrate, and a cover over the porous material layer and sealingly affixed to the substrate. The cover may be spaced from the porous material layer and a flow channel defined between the porous material layer and the cover. The flow channel may have a uniform cross-section from a first end to a second end.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: September 2, 2014
    Assignees: Applied Biosystems, LLC, The United States of America, as represented by the Secretary, Department of Health and Sciences
    Inventors: James F. Brown, Jonathan E. Silver
  • Patent number: 8822230
    Abstract: In a chromatography quantitative measuring apparatus according to the present invention, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: September 2, 2014
    Assignee: Panasonic Healthcare Co., Ltd.
    Inventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
  • Patent number: 8796012
    Abstract: A technique for high sensitivity evanescent field molecular sensing employs a detection scheme that simultaneously couples a polarized beam to a single mode of a waveguide, and couples the polarized beam out of the waveguide to specularly reflect the beam by the same grating. Strong interaction with the single (preferably TM) mode is provided by using a silicon on insulator (SOI) wafer having a waveguide thickness chosen between 10-400 nm so that the majority of the mode field strength spans the evanescent field. Well known, robust techniques for producing a grating on the waveguide are provided. Interrogation from a backside of the SOI wafer is taught.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 5, 2014
    Assignee: National Research Council of Canada
    Inventors: Bill Sinclair, Jens Schmid, Philip Waldron, Dan-Xia Xu, Adam Densmore, Trevor Mischki, Greg Lopinski, Jean Lapointe, Daniel Poitras, Siegfried Janz
  • Patent number: 8795523
    Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: August 5, 2014
    Assignee: Intel Corporation
    Inventors: Xing Su, David J. Liu, Kai Wu, Kenneth B. Swartz, Mineo Yamakawa
  • Patent number: 8784749
    Abstract: This invention provides a digital microfluidic manipulation device and a manipulation method thereof. This device comprises a PDMS membrane having a surface comprising a plurality of hydrophobic microstructures; a plurality of air chambers arranged in an array and placed under the PDMS membrane; and a plurality of air channels, each of which connects to a corresponding one of the plurality of air chambers. When a suction force is transmitted via one of the plurality of air channels to the corresponding air chamber, a portion of the PDMS membrane above the air chamber deforms toward the air chamber, so that the surface morphology and the contact angle of the liquid/solid interface of the surface comprising the plurality of hydrophobic microstructures are altered and thereby to drive droplets.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: July 22, 2014
    Assignee: National Taiwan University
    Inventors: Jing-Tang Yang, Chao-Jyun Huang, Chih-Yu Hwang
  • Patent number: 8778279
    Abstract: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard sterilization capabilities. In other embodiments, microfluidic devices have integral collection bags and methods for keeping the microfluidic channels clean.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: July 15, 2014
    Assignees: Sony Corporation, Sony Corporation of America
    Inventor: Gary P. Durack
  • Patent number: 8778698
    Abstract: In a chromatography quantitative measuring apparatus, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: July 15, 2014
    Assignee: Panasonic Healthcare Co., Ltd.
    Inventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
  • Patent number: 8753872
    Abstract: A method and apparatus for assay of multiple analytes. The method uses a sensing element comprising a substrate upon which is arranged a multiplicity of recognition elements, such that each element is laid out in a predetermined pattern. Each pattern is unique in that it can give rise to a characteristic diffraction pattern in the assay. The patterns may or may not be interpenetrating on the substrate surface. The method of detecting multiple analytes includes contacting the medium of analytes with the patterned substrate, illuminating the substrate by a light source, and detecting any resultant diffraction image. The pattern of diffraction and the intensity of the diffracted signal provides information about the existence of specific analytes and their quantification.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: June 17, 2014
    Assignee: Axela Inc.
    Inventors: M. Cynthia Goh, Jane B. Goh, Richard Mcaloney, Richard Loo
  • Patent number: 8753895
    Abstract: The present invention provides a metal nanoparticle that is surface-modified with a hydrophilic or hydrophobic functional group, and a composition for optical detection comprising the same. The surface-modified nanoparticles according to the present invention form clusters suitable for optical detection, for example, suitable as an X-ray contrast agent, and have surface plasmon energy in the visible region, thereby being usefully applied to a variety of optical detection methods.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: June 17, 2014
    Assignee: Postech Academy-Industries Foundation
    Inventors: San Joon Lee, Sung Yong Jung, Sungsook Ahn, Jin Pyung Lee, Hae Koo Kim
  • Patent number: 8747779
    Abstract: A microfluidic cartridge including on-board dry reagents and microfluidic circuitry for determining a clinical analyte or analytes from a few microliters of liquid sample; with docking interface for use in a host workstation, the workstation including a pneumatic fluid controller and spectrophotometer for monitoring analytical reactions in the cartridge.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: June 10, 2014
    Assignee: Micronics, Inc.
    Inventors: Isaac Sprague, John E. Emswiler, C. Frederick Battrell, Joan Haab, Sean M. Pennell, Justin L. Kay, Zane B. Miller, Troy D. Daiber
  • Patent number: 8722426
    Abstract: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: May 13, 2014
    Assignee: Quidel Corporation
    Inventors: Paul Lambotte, Michael Cerrito, Cecille Ramirez
  • Patent number: 8722347
    Abstract: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: May 13, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Todd H. Rider, Laura Bortolin
  • Patent number: 8716026
    Abstract: Methods and systems for determining composition and completion of an experiment are provided. One-computer-implemented method for determining composition and completion of an experiment includes determining one or more characteristics of data acquired during the experiment and determining if the experiment is completed based on the one or more characteristics. One system configured to determine composition and completion of an experiment includes a processor configured to determine one or more characteristics of data acquired during the experiment and to determine if the experiment is completed based on the one or more characteristics. Another system configured to perform an experiment includes a measurement subsystem configured to acquire data during the experiment and a processor configured to determine one or more characteristics of the data during the experiment and to determine the composition of the experiment and if the experiment is completed based on the one or more characteristics.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: May 6, 2014
    Assignee: Luminex Corporation
    Inventor: Allen G. Ward
  • Patent number: 8709356
    Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: April 29, 2014
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
  • Patent number: 8703505
    Abstract: A biosensor having an optical fiber having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the optical fiber, and configured to enhance localized surface plasmon resonance.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: April 22, 2014
    Assignee: Indian Institute of Technology Bombay
    Inventors: Vemulakonda Venkata Raghavendra Sai, Soumyo Mukherji, Tapanendu Kundu
  • Patent number: 8703504
    Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: April 22, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Xuedong Song
  • Patent number: 8703070
    Abstract: Apparatus for immunoassay includes: a cartridge, including at least one test unit; a pin-film assembly, having a second sealing film, a plurality of pierce mechanisms, and a first actuation unit; a plurality of magnetic particles; at least one first magnetic unit; and at least one second magnetic unit. The test unit includes a plurality of fluid chambers, a plurality of pin chambers, a microchannel structure, a buffer chamber, a detection chamber and a waste chamber. The first actuation unit drives the pierce mechanisms to enable a working fluid to flow into the detection chamber storing the magnetic particles. As the second magnetic unit has a magnetic force larger than that of the first magnetic unit and can move reciprocatingly between a third position and a fourth position, the magnetic particles are driven to move reciprocatingly inside the detection chamber, thereby fully mixing the magnetic particles with the working fluid.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: April 22, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Shaw-Hwa Parng, Chih-Wen Yang, Yu-Yin Tsai, Yi-Chau Huang
  • Patent number: 8697435
    Abstract: A system for sample preparation and analyte detection includes a cartridge, with a fluidic channel, a waveguide, and a capture spot. The system further includes a force field generator, an imaging system, and a fluid, which includes a sample potentially containing a target analyte, first type particles, which include binding moieties specific for the target analyte and are responsive to a force field, and second type particles, which include binding moieties specific for the target analyte and are capable of generating a signal. When the sample contains the target analyte, specific binding interactions between the target analyte and binding moieties link first and second type particles via the target analyte to form multiple-particle complex capturable at a capture spot. The force field allows manipulation of the particles and multiple-particle complex such that the detected signal from the second type particles is indicative of the target analyte within the sample.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: April 15, 2014
    Assignee: MBio Diagnostics, Inc.
    Inventors: James R. Heil, Michael J. Lochhead, Kevin D. Moll, Christopher J. Myatt
  • Patent number: 8697008
    Abstract: A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: April 15, 2014
    Assignee: Eastman Kodak Company
    Inventors: Andrew Clarke, Nicholas J. Dartnell, Christopher B. Rider
  • Patent number: 8673650
    Abstract: Optical detection of molecules using a biochip having at least one reagent immobilizing area designed to receive one or more reagents and at least one calibration structure with a predetermined height to provide a height reference for optical measurement is disclosed. When the calibration structure is illuminated by a probe beam of light, a first reflected beam of light is reflected off the calibration structure, and a second reflected beam of light is reflected off the reagent immobilizing area. The first reflected beam and the second reflected beam are compared to determine a height at the reagent immobilizing area.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: March 18, 2014
    Assignee: Ridge Diagnostics, Inc.
    Inventor: Bo Pi
  • Patent number: 8652409
    Abstract: Fluid analyte sensors include a photoelectrocatalytic element that is configured to be exposed to the fluid, if present, and to respond to photoelectrocatalysis of at least one analyte in the fluid that occurs in response to impingement of optical radiation upon the photoelectrocatalytic element. A semiconductor light emitting source is also provided that is configured to impinge the optical radiation upon the photoelectrocatalytic element. Related solid state devices and sensing methods are also described.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: February 18, 2014
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
  • Patent number: 8647883
    Abstract: A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: February 11, 2014
    Assignee: General Electric Company
    Inventors: Radislav A. Potyrailo, Timothy M. Sivavec, Caibin Xiao, Theodore J. Cecconie, Lamyaa Hassib, Andrew M. Leach, David B. Engel
  • Patent number: 8647889
    Abstract: The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 11, 2014
    Assignee: Access Medical Systems, Ltd.
    Inventors: Robert F. Zuk, Hong Tan