Apparatus Included In Process Claim (e.g., Physical Support Structures, Etc.) Patents (Class 436/807)
  • Patent number: 9034657
    Abstract: A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location; allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location; and, after a predetermined period of time, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and which is dried on the lateral flow matrix at a location upstream of the sample port delivery of the sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species and bind with any IgE antibody bound to the immobilized IgE antigen species, a
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: May 19, 2015
    Assignee: Phadia AB
    Inventors: Gerd Rundström, Per Matsson, Paul Christopher
  • Patent number: 9029101
    Abstract: Microplate reader with optical measuring/detection device has housing, a microplate support and a moving unit. The moving unit moves the microplate support out and into the housing and horizontally within the housing. The reader has an integrated lid holding apparatus within the housing for lifting and placing a microplate lid on the microplate. The lid holding apparatus moves the microplate lid and/or the microplate support for moving the microplate in one respective vertical direction. A method for optically measuring a microplate in such a microplate reader places a covered microplate on the microplate support, retracts it into the housing, lifts the lid from the microplate, measures the microplate with the lifted lid, replaces the lid, and extends the support and the covered microplate out of the housing.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: May 12, 2015
    Assignee: Tecan Trading AG
    Inventors: Friedrich Menges, Harald Gebetsroither, Gyoergy Wenczel
  • Patent number: 9017995
    Abstract: A liquid-transport device has a liquid-tight support (12) on which there is applied a start zone (24; 24?) for applying transport liquid to be transported and a target zone (26, 28; 26a-e) into which the transport liquid is to be transported and also a conduction zone that extends between the start zone (24, 24?) and the target zone (26, 28; 26a-e) and that has a microporous transport layer (14) in which the transport liquid flows by capillary force from the start zone (24; 24?) to the target zone (26, 28; 26a-e). The conduction zone has a multiplicity of open flow channels separated from one another by microporous bridges having open-pored side walls.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: April 28, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Karl Pflanz, Eric Jallerat, Darius Haeusler, Markus Hollas, Uwe Andag
  • Patent number: 8999264
    Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 7, 2015
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael J. Pugia
  • Patent number: 8980177
    Abstract: Disclosed is a fluidic assay device for assaying at least one property of a liquid sample, the device comprising: (i) a liquid sample application region; (ii) at least one test flow path in liquid flow communication with the sample application region; (iii) a reference flow path in liquid flow communication with the sample application region; and (iv) a junction region, at which the test flow path and the reference flow path contact one another, the junction region typically comprising an outlet, conduit, chamber or other portion which permits the onward flow of liquid; wherein a liquid flowing along the reference flow path, upon reaching the junction region, has the effect of preventing the flow of liquid along the test flow path. The invention relates to a fluidic device for the passage of a liquid. It also relates to an assay device suitable for measurement of the amount and/or presence of an analyte in, or property of, a fluid sample.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: March 17, 2015
    Assignee: Alere Switzerland GmbH
    Inventors: Stephen John Carlisle, David Tolley
  • Patent number: 8968674
    Abstract: Provided herein is a fluid sensor, which includes a closed reaction unit in which reaction of a fluid sample takes place. The reaction unit is tapered on a side through which the fluid is injected so as to prevent generation of air bubbles during the injection of the fluid. Thus, the sensor has improved sensitivity.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: March 3, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hun Joo Lee, Soo Suk Lee, Jung Nam Lee
  • Patent number: 8921122
    Abstract: The present invention provides systems and methods for assessing migration behavior of biological particles, such as neutrophils, under the effect of a gradient. The systems can include one or more migration chambers, one or more gradient sources configured to generate particular gradients, e.g., of chemokines or the like across the width of the migration chamber, and a detection arrangement that is configured to determine spatial profiles across the migration chamber that indicate the extent of migration.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: December 30, 2014
    Assignee: The General Hospital Corporation
    Inventor: Daniel Irimia
  • Patent number: 8912005
    Abstract: An array of sensors arranged in matched pairs of transistors with an output formed on a first transistor and a sensor formed on the second transistor of the matched pair. The matched pairs are arranged such that the second transistor in the matched pair is read through the output of the first transistor in the matched pair. The first transistor in the matched pair is forced into the saturation (active) region to prevent interference from the second transistor on the output of the first transistor. A sample is taken of the output. The first transistor is then placed into the linear region allowing the sensor formed on the second transistor to be read through the output of the first transistor. A sample is taken from the output of the sensor reading of the second transistor. A difference is formed of the two samples.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: December 16, 2014
    Assignee: Life Technologies Corporation
    Inventors: Keith G. Fife, Jungwook Yang
  • Patent number: 8808627
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: August 19, 2014
    Assignee: Meso Scale Technologies, LLC
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • Patent number: 8796036
    Abstract: An array of sensors arranged in matched pairs of transistors with an output formed on a first transistor and a sensor formed on the second transistor of the matched pair. The matched pairs are arranged such that the second transistor in the matched pair is read through the output of the first transistor in the matched pair. The first transistor in the matched pair is forced into the saturation (active) region to prevent interference from the second transistor on the output of the first transistor. A sample is taken of the output. The first transistor is then placed into the linear region allowing the sensor formed on the second transistor to be read through the output of the first transistor. A sample is taken from the output of the sensor reading of the second transistor. A difference is formed of the two samples.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: August 5, 2014
    Assignee: Life Technologies Corporation
    Inventors: Keith Fife, Jungwook Yang
  • Patent number: 8790578
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: July 29, 2014
    Assignee: Meso Scale Technologies, LLC
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • Patent number: 8765485
    Abstract: Various aspects of the present invention relates to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: July 1, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Darren Roy Link, David A. Weitz, Galder Cristobal-Azkarate, Zhengdong Cheng, Keunho Ahn
  • Patent number: 8759115
    Abstract: An assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label. The device includes a substrate surface having a sample addition zone, a reaction zone and an absorbing zone, the zones being connected by at least one fluid passage, wherein the device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone. Both functionality verifying features are capable of undergoing a detectable change when contacted by the sample, in which the assay device further includes at least one alignment verification zone. There is further provided a kit of parts and a method of conducting an assay.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: June 24, 2014
    Assignee: Johnson & Johnson AB
    Inventors: Per Ove Ohman, Ib Mendel-Hartvig, Tomas Lindstrom
  • Patent number: 8709826
    Abstract: The invention relates to a device for determining an analyte in a liquid sample. The inventive device consists of: a capillary action means, involving lateral migration, defining a reference capillary action direction and comprising a liquid sample deposit area and an analytedetection area which is disposed downstream of the deposit area; a first analytespecific binding reagent which is conjugated to a visible and/or measurable marker and which is free to migrate when wet by means of capillary action in the abovementioned capillary actions means along the reference direction; and a second analytespecific binding reagent which is immobilized in the detection area. The invention is characterized in that the detection area comprises the analyte or an analogue of the analyte, which is immobilized and disposed at a distance from the second specific binding reagent.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: April 29, 2014
    Assignee: Vedalab
    Inventor: Raphael Donati
  • Patent number: 8679855
    Abstract: In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied current, surface plasmons in “just-continuous” low resistance films are sparsely available for fluorophore dipole coupling and hence the enhanced fluorescence is gated as a function of the applied current.
    Type: Grant
    Filed: March 1, 2009
    Date of Patent: March 25, 2014
    Assignee: University of Maryland, Baltimore County
    Inventor: Chris D. Geddes
  • Patent number: 8647574
    Abstract: A system and method for preparing and collecting samples for analyte testing. The system can include a sample preparation system and a sample collection system coupled to the sample preparation system. The sample preparation system can include at least one of a deformable self-supporting receptacle comprising a reservoir and a freestanding receptacle comprising a reservoir. The reservoir can be adapted to contain a liquid composition. The sample collection system can be positioned in fluid communication with a reservoir of the sample preparation system, and can be adapted to capture an analyte of interest. The method can include providing a fluid path defined at least partially by the sample preparation system and the sample collection system, positioning the liquid composition in a reservoir of the sample preparation system, and moving at least a portion of the liquid composition in the fluid path to the sample collection system.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: February 11, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Kurt J. Halverson, Stephen C. P. Joseph, Raj Rajagopal, David J. Velasquez, Cynthia D. Zook, Sailaja Chandrapati, Daniel E. Siltberg, Paul J. Cobian, Theresa J. Gerten
  • Patent number: 8636954
    Abstract: The present invention relates to calibration slides for fluorescence detection instruments and processing method of making them. The aim of this invention is to disclose calibration slides with high photostability and long lifetime for fluorescence detection instruments. The calibration slides are fabricated by patterning calibration spot arrays of modified inorganic phosphors on the glass slide. The process for producing a calibration slide comprises the following procedure: 1) Dispersing the inorganic phosphors of rare-earth doped complex in water; 2) Patterning the array of the above suspension on the glass slide. The calibration slides in the present invention employ a very stable fluorescing material that is insensitive to photobleaching, has long lifetime and stability under mild storage condition. The calibration slides in the present invention can be used to calibrate and test for some fluorescence instruments, i.e.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: January 28, 2014
    Assignees: CapitalBio Corporation, Tsinghua University
    Inventors: Yu Ge, Wenjun Yang, Shuying Zhao, Lianghong Guo, Jing Cheng
  • Patent number: 8623639
    Abstract: The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable GGBPs. The present invention also relates to nucleic acids encoding these thermostable GGBPs.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: January 7, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Terry J. Amiss, Erin M. Gill, Douglas B. Sherman
  • Patent number: 8609433
    Abstract: A sample compressor applies pressure to a sample collector and a sample application zone of a test strip to transfer a sample from the sample collector and a binding partner of an analyte to the sample application zone in a lateral flow device. At least one of the binding partners of the analyte is not located on the test strip prior to use of the lateral flow device. The test strip may be a universal test strip with no molecule that specifically binds the analyte is located on the test strip. The sample compressor may be a universal sample compressor also with no molecule that specifically binds the analyte on the sample compressor. The lateral flow device may also include one or more enhancement elements, where the enhancement elements bind to the analyte sandwich to increase a detection signal in the test zone.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: December 17, 2013
    Assignee: Rapid Pathogen Screening, Inc.
    Inventors: Robert P. Sambursky, Uma Mahesh Babu, Robert W. VanDine, Ganga V. Kanaujia, Thomas Orsini
  • Patent number: 8580570
    Abstract: A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 ?m. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: November 12, 2013
    Assignee: Northeastern University
    Inventors: Barry L. Karger, Jian Zhang
  • Patent number: 8580576
    Abstract: A method for the transfer of a bodily fluid sample (such as a whole blood sample) during the determination of an analyte (e.g., glucose) in the bodily fluid sample includes applying the bodily fluid sample to a sample collection reservoir of an analytical test strip (for example, an electrochemical-based analytical test strip). During such application, the sample collection reservoir is isolated from fluid communication with a determination chamber of the analytical test strip. The analytical test strip is subsequently inserted into a test meter such that the sample collection reservoir is placed into fluid communication with the determination chamber and such that at least a portion of the bodily fluid sample is consequentially transferred from the sample collection reservoir to the determination chamber. The method further includes determining the analyte in the bodily fluid sample transferred to the determination chamber.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: November 12, 2013
    Assignee: Cilag GmbH International
    Inventors: Khalid R. Quraishi, David Matzinger
  • Patent number: 8569076
    Abstract: A method and system for performing a serological agglutination assay in a liquid sample. The system provides a simple method for creating an in-situ sample/reagent admixture within a sample analysis chamber without the use of any precision fluid-handling components.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: October 29, 2013
    Assignee: Abbott Point of Care, Inc.
    Inventors: Stephen C. Wardlaw, Robert A. Levine
  • Patent number: 8563297
    Abstract: Disclosed are methods for controlling molecular interactions where at least one member of a pair of chemical entities having a pH-dependent affinity is immobilized on the surface of an electrode. By changing the potential difference between the electrode and a counter electrode, the affinity of the pair of chemical entities is changed, changing the tendency of the pair to bind or to dissociate. Disclosed are also devices useful for implementing the methods of the present invention.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: October 22, 2013
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Uri Sivan, Elad Brod
  • Patent number: 8557609
    Abstract: A method employing gel electrophoresis and optical imaging techniques to measure the amount of biomaterial that attaches to specified locations on a detector slide such as a bioarray or biochip.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: October 15, 2013
    Assignee: Maven Biotechnologies, LLC
    Inventors: Shane Dultz, David Ralin, William Rassman
  • Patent number: 8535622
    Abstract: The present invention provides a naturally based Sperm Separation System (SSS) for separation of at least a portion of sperm cell populations (SCP) within an original semen sample, such that an enriched SCP sample is obtained, comprising a a sperm separation device, comprising ?) a first chamber adapted to contain at least a portion of said original semen sample, said first chamber is characterized by predetermined 3D shape and volume, V, said first chamber is bounded by a rim such that said orginal sample is kept below said rim, n) a second chamber in physical communication with said first chamber and said nm, said second chamber is characterized by predetermined 3D shape and volume, V1, said second chamber is adapted to reside said enriched SCP sample, b incubation means, adapted to socket at least one of said cell separation device and to homogeneously thermoregulate the temperature within the same.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: September 17, 2013
    Assignee: Lotus Bio (Nymphaea) Ltd
    Inventors: Vered Shany, Isaac Tavori
  • Patent number: 8529837
    Abstract: A system and method for detecting specific binding reactions using magnetic labels.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: September 10, 2013
    Assignee: Biomag Corp.
    Inventors: Clayton M. Hardman, Sanjay R. Mishra
  • Patent number: 8496878
    Abstract: An immunodiagnostic test card includes a flat planar member and at least one dilution chamber that is supported by the flat planar member. The at least one dilution chamber can be disposed adjacent chambers used for testing a patient sample that are provided on the immunodiagnostic test card or can be provided separately.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: July 30, 2013
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Raymond Francis Jakubowicz, William G. Atterbury, Douglas E. Boyd, Michael L. Marshall
  • Patent number: 8492136
    Abstract: Disclosed is a fluidic assay device for assaying at least one property of a liquid sample comprising: a liquid sample application region; at least one test flow path in liquid flow communication with the sample application region; a reference flow path in liquid flow communication with the sample application region; and a junction region, at which the test flow path and the reference flow path contact one another, the junction region typically comprising an outlet, conduit, chamber or other portion which permits the onward flow of liquid; wherein a liquid flowing along the reference flow path, upon reaching the junction region, has the effect of preventing the flow of liquid along the test flow path. The invention relates to a fluidic device for the passage of a liquid and an assay device suitable for measurement of the amount and/or presence of an analyte in, or property of, a fluid sample.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: July 23, 2013
    Assignee: Alere Switzerland GmbH
    Inventors: Stephen John Carlisle, David Tolley
  • Patent number: 8476078
    Abstract: A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: July 2, 2013
    Assignee: Luminex Corporation
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Patent number: 8476082
    Abstract: Devices and methods for the detection of target molecules are disclosed. Devices and methods for detecting food-borne target molecules are also disclosed.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: July 2, 2013
    Assignee: Invisible Sentinel, Inc.
    Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
  • Patent number: 8414845
    Abstract: A sample processing vessel may include a branch segment and at least two tracks. The at least two tracks may be fluidly isolated from one another by a permanent seal. The tracks may be segmented by breakable seals. The branch segment may be temporarily isolated from the tracks by breakable seal(s) and put in fluid communication with the tracks once those seal(s) are broken, such that fluid received by the branch segment is divided into portions that pass into both tracks.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: April 9, 2013
    Assignee: Iquum, Inc.
    Inventors: Shuqi Chen, Bertrand Lemieux, Lingjun Chen
  • Patent number: 8383422
    Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 26, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Junichi Katada, Hideyuki Karaki, Takayoshi Oyamada
  • Patent number: 8383421
    Abstract: An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: February 26, 2013
    Assignee: Mitsubishi Chemical Medience Corporation
    Inventors: Atsushi Yanagida, Takashi Kurihara, Hiroyuki Yokoi, Atsushi Koyata, Yoshikazu Okamura, Daishi Miyamoto
  • Patent number: 8372655
    Abstract: The present invention provides a plate for mass spectrometry comprising a support and a PVDF-containing coating (that is, a PVDF-deposited thin layer) thereon, and a method of preparing a plate for mass spectrometry, which comprises coating the support surface with PVDF. The present invention also provides a method of analyte identification comprising subjecting an analyte-containing sample to gel electrophoresis to separate the analyte, blotting the separated analyte from the gel to the above-described plate for mass spectrometry, and subjecting the plate to mass spectrometry, whereby the transferred analyte is analyzed.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: February 12, 2013
    Assignee: Protosera Inc.
    Inventors: Kenji Tanaka, Lyang-ja Lee, Koji Munechika, Hisashi Arikuni, Bungo Ochiai
  • Patent number: 8357541
    Abstract: Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: January 22, 2013
    Assignee: Allergan, Inc.
    Inventors: Jennifer L. Ton, Hemant A. Patel, Ronald C. Bates, Wajdie M. Ahmad
  • Patent number: 8343778
    Abstract: The invention encompasses microfluidic microarray assemblies (MMA) and subassemblies and methods for their manufacture and use. In one embodiment, first and second channel plates are provided and are sealingly connected to a test chip in consecutive steps. Each plate includes microfluidic channels configured in a predetermined reagent distribution pattern. The test chip comprises a plurality of discrete test positions, each test position being located at the intersection between a first predetermined reagent pattern and a second predetermined reagent pattern, wherein at least one of said patterns is non-linear. The first channel plate allows the distribution of a first reagent on said test chip, wherein said first reagent is immobilized at said test positions. The second channel plate allows the distribution of a second reagent on said test chip, wherein said second reagent comprises a plurality of different test samples.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: January 1, 2013
    Assignee: Simon Fraser University
    Inventors: Hua Zhong Yu, Meenakshinathan Parameswaren, Paul Chi Hang Li, Xing Yue Peng, Hong Chen, Wa Lok Chou
  • Patent number: 8343356
    Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: January 1, 2013
    Assignee: EMD Millipore Corporation
    Inventors: Jean-Luc Beulay, Virginie Buisson, Sebastien Cirou, Cecile Delbos, Marc Hlavacek, Frans Mels, Rene Reinbigler, Jean-Louis Weissenbach
  • Patent number: 8338164
    Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: December 25, 2012
    Assignee: The Foundry, LLC
    Inventors: Mark E. Deem, Hanson Gifford
  • Patent number: 8338191
    Abstract: The invention relates to a device for performing binding assays. In particular, the invention relates to a centrifugal device for performing such assays. The invention also relates to a method of performing binding assays involving antigen-antibody binding, nucleic acid hybridization, or receptor-ligand interaction.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignee: Corbett Life Science Pty Ltd
    Inventors: John Michael Corbett, John Michael Corbett, Jr.
  • Patent number: 8313643
    Abstract: A system and method for analyzing a biological substance, the device comprising: a specimen input device; at least one pumping device in flow communication with a chemical reservoir and said specimen input device; and at least one flow cell in flow communication with said at least one pumping device via at least one flow valve, wherein said at least one flow cell is configured to contain said specimen and includes a sensing device configured to sense at least one characteristic of said specimen.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: November 20, 2012
    Inventor: David Baltimore
  • Patent number: 8309364
    Abstract: An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a portion of the signal arises from non-specific binding of the labeled antibody in the region of the first immunosensor, and a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein that is in the sample and that is not the target analyte.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: November 13, 2012
    Assignee: Abbott Point of Care Inc.
    Inventors: Cary James Miller, John Lewis Emerson Campbell
  • Patent number: 8288155
    Abstract: Methods of addressing a biomolecule to a selectively addressable electrode are described. A permeation layer overlying a plurality of selectively addressable electrodes is provided. The permeation layer includes a reactive group that is adapted to bond to a biomolecule and that requires activation through a chemical transformation before bonding to the biomolecule. At least one selectively addressable electrode is biased such that a pH change occurs in an overlying solution of the at least one selectively addressable electrode. The reactive group in a portion of the permeation layer above the at least one selectively addressable electrode is then chemically transformed to an activated reactive group as a result of the pH change. A biomolecule is then bound to the permeation layer overlying the at least one selectively addressable electrode through the activated reactive group.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: October 16, 2012
    Assignee: Gamida for Life B.V.
    Inventors: John R. Havens, Thomas J. Onofrey, Charles H. Greef, Gregory J. Kevorkian, Jain Krotz, Kristie L. Lykstad, Daniel E. Raymond, Howard R. Reese, Regina Rooney, John J. Scott
  • Patent number: 8288164
    Abstract: The present invention provides a highly reliable reaction cuvette in which air bubbles are adhered little and mutual contamination can be prevented among samples and reagents in adjoining reaction cuvettes, a method of surface treatment for a reaction cuvette, and an automatic analyzer with the reaction cuvette mounted therein. The reaction cuvette according to the present invention, in which a sample and a reagent are mixed with each other and its concentration is measured, has an area subjected to hydrophilic treatment by electric discharging on inner and outer surfaces of the reaction cuvette. Further the reaction cuvette has a container-like form with its upper portion opened to provide an opening and its lower portion closed to provide a bottom. The hydrophilic area is present from a bottom of the reaction cuvette up to a midway to the opening.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: October 16, 2012
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hiroyuki Mishima, Hiroaki Ishizawa, Masashi Endo
  • Patent number: 8283185
    Abstract: The present invention includes a magnetically susceptible polymer component, a method of making the same, and apparatuses and systems for mixing, separating or localizing a magnetically susceptible polymer compound in a reaction. The magnetically susceptible polymer component includes a polymer and a magnetically susceptible particle of a predetermined size, which yields a component having a much-improved magnetic reactivity due to the increase in magnetic material by mass percentage. The apparatuses and systems of the present invention employ controllable magnetic fields distributable in perpendicular directions in order to precisely control the orientation, position and relative motion of any magnetically susceptible components within a reaction vessel.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: October 9, 2012
    Assignee: STC.UNM
    Inventors: Bentley Paul, Davenport Michael
  • Patent number: 8283181
    Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: October 9, 2012
    Assignee: The Regents of the University of California
    Inventors: Daniel Pinkel, Donna G. Albertson, Greg Hamilton, Nils W. Brown, Robert Nordmeyer
  • Patent number: 8268636
    Abstract: The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a binding member reactive with a first epitope of the analyte and a label comprising a gold colloid, preferably having a mean particle size of 50 nm to 100 nm. In further embodiments, the device comprises a capture component comprising polymerized streptavidin. The diagnostic device is particularly useful in the preparation of pregnancy test kits.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: September 18, 2012
    Assignee: Church & Dwight Co., Inc.
    Inventors: Albert Nazareth, Timothy Snowden, Yea-shun Cheng
  • Patent number: 8247219
    Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: August 21, 2012
    Assignee: Applied Biosystems, LLC
    Inventors: Timothy Woudenberg, Michael Albin, Reid B. Kowallis, Yefim Raysberg, Robert P. Ragusa, Emily S. Winn-Deen
  • Patent number: 8246910
    Abstract: Sensing device and method for detecting presence and concentration of generic target analytes of interest. The device and method are based on detecting changes in effective dielectric induced by the target analytes of interest. Applications of the invention include, but are not restricted to, detecting and characterizing the presence of chemical and/or biological target analytes of interest as well as detecting and characterizing target analytes of interest from a separation apparatus. In one embodiment of the invention, the device comprises at least two electrodes in a rigid architecture such as a solid surface, where the electrodes have sizes and inter-electrode spacings that are on the order of sizes of target analytes of interest to improve sensitivity of the device. Changes in effective dielectric and, therefore, capacitance induced by a presence of the target analytes of interest are measured electronically.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: August 21, 2012
    Assignee: Universal Nanosensor Technologies Inc.
    Inventors: Al-Amin Dhirani, Yoshinori Suganuma
  • Patent number: 8236555
    Abstract: The present invention is directed to methods for conducting multiplexed assays. The methods are particularly well suited for measuring a plurality of analytes that may be present in very different abundances. The invention also relates to systems, devices, equipment, kits and reagents for use in such methods.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: August 7, 2012
    Assignee: Meso Scale Technologies, LLC
    Inventors: Selen A. Stromgren, Eli N. Glezer
  • Patent number: 8211367
    Abstract: A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte comprises a step in which the sample is received in a vessel with at least one flexible wall. In another step, an additive and particles are added to the sample, wherein the additive substantially binds to the at least one of the stem cell, lymphocyte, and leukocyte, and the particles and wherein the particles substantially bind to the at least one of the stem cell, lymphocyte, and leukocyte, and the additive, thereby producing a cell-containing network. In a further step, the network is separated from the substantially cell-depleted portion by applying a magnetic force.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: July 3, 2012
    Inventors: James Wyatt, Matthew Scott, Vijay Mahant