Involving Complement Factors Or Complement Systems Patents (Class 436/821)
  • ATCC HB8116 And its monoclonal anti-H-Y antibody, Hyclonalan
    Patent number: 4511661
    Abstract: Hybridoma tumor cell line A.T.C.C. No. HB8116. An anti-H-Y antigen monoclonal antibody substance, "Hyclonalan," produced by said cell line. Use of Hyclonalan in immunoselection methodology.
    Type: Grant
    Filed: December 30, 1983
    Date of Patent: April 16, 1985
    Assignee: University Patents, Inc.
    Inventor: Ellen H. Goldberg
  • Complement assay method
    Patent number: 4492761
    Abstract: A method of determining (1) the activity of complement, (2) the bacteriolytic activity of serum, or (3) the titer of antibody in a sample which comprises: (a) incubating complement-sensitive microorganisms containing an assayable intracellular component with the sample, and (b) detecting the assayable component released into the sample by lysis of the microorganisms.
    Type: Grant
    Filed: April 5, 1982
    Date of Patent: January 8, 1985
    Assignee: Duke University
    Inventor: David T. Durack
  • Method for HLA-DR typing of total human lymphocyte sample
    Patent number: 4471056
    Abstract: An HLA-DR typing test based on lymphocytotoxicity in which a vital dye-labeled total human lymphocyte sample, such as a sample of peripheral blood lymphocytes, is incubated with HLA-DR antisera, a monoclonal antibody against T cells, and complement and the DR type is determined based upon the resultant cytotoxicity as measured by the fluorescence of B cells surviving the incubation.
    Type: Grant
    Filed: April 2, 1982
    Date of Patent: September 11, 1984
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Frank C. Grumet, Edgar G. Engleman
  • Agglutination-inhibition test method for detecting immune complexes
    Patent number: 4427779
    Abstract: Method for detecting circulating immune complexes containing endogenously bound Clq. Capillary tubes are filled with a mixture of Clq coated GPO reagent cells, rabbit anti-Clq antibodies, and precipitate from the biological fluid sample containing immune complexes. The mixture is allowed to react and the tubes read for the presence or absence of agglutination indicative of the absence or presence of said immune complexes respectively.
    Type: Grant
    Filed: May 26, 1982
    Date of Patent: January 24, 1984
    Assignee: Ortho Diagnostic Systems Inc.
    Inventors: Rudolph P. Reckel, Joanne L. Harris
  • Particle agglutination immunoassay with agglutinator for determining haptens; PACIA
    Patent number: 4427781
    Abstract: A particle counting assay for haptens (small non-protein monovalent substances having a molecular weight below 1500) comprises mixing a liquid sample (e.g. of human origin) containing the hapten, with finely divided inert particles bearing the same hapten (or a specific analogue thereof), an agglutinator such as RF or C1q, and a measured amount of antibody, which amount is insufficient to cause agglutination of all the particles. The amount of hapten is determinable by measuring the extent of the agglutination.
    Type: Grant
    Filed: January 24, 1984
    Date of Patent: January 24, 1984
    Assignee: International Institute of Cellular and Molecular Pathology
    Inventors: Pierre L. Masson, Daniel Collet-Cassart, Carl G. Magnusson