Fetal Lung Maturity Patents (Class 436/907)
  • Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor
    Patent number: 5856196
    Abstract: Processes for detecting or quantitating a particular phosphoglyceride in a sample containing the phosphoglyceride and other lipids and clinical uses for the process (e.g. for diagnosing improperly functioning lungs and other conditions) are disclosed.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: January 5, 1999
    Assignee: Beth Israel Hospital
    Inventors: Juan G. Alvarez, Jack Ludmir
  • Monoclonal antibodies to human pulmonary surfactant apoprotein D and use thereof
    Patent number: 5670328
    Abstract: A monoclonal antibody which is capable of specifically binding with human pulmonary surfactant apoprotein D has been successfully obtained. Using the monoclonal antibody, human pulmonary surfactant apoprotein D can be specifically detected and assayed, whereby diagnosis of respiratory diseases is enabled.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: September 23, 1997
    Assignee: Yamasa Corporation
    Inventors: Takeshi Inoue, Eiji Matsuura, Yoshio Kuroki, Toyoaki Akino, Shosaku Abe
  • Method for assessing lung maturity using fluorescence from naphthalene-based probes
    Patent number: 5227308
    Abstract: A method for assessing lung maturity in a fetus or an infant comprises adding a fluorescent dye to a pulmonary effluent, causing the dye to fluoresce by illumination with an excitation wavelength of monochromatic light, and measuring the intensity of the fluorescence at two different wavelengths. Alternatively, the method comprises sequential illumination with two different excitation wavelengths and measurement of the intensity of fluorescence caused by each excitation wavelength at a single emission wavelength.
    Type: Grant
    Filed: November 5, 1991
    Date of Patent: July 13, 1993
    Assignee: University of Hawaii
    Inventors: David M. Jameson, Nadhipuram V. Bhagavan
  • Method and test kit for the determination of fetal pulmonary maturity status
    Patent number: 5010016
    Abstract: A test kit and method of determining fetal pulmonary maturity which method comprises visually comparing a test amniotic fluid with selected positive and negative control samples and which test kit includes selected positive and negative control samples for comparison purposes.
    Type: Grant
    Filed: August 9, 1989
    Date of Patent: April 23, 1991
    Inventor: Anthony J. Sbarra
  • Fluorescence polarization method for monitoring fetal lung maturity
    Patent number: 4784961
    Abstract: The present invention is directed to a fluorescence polarization method for monitoring fetal lung maturity, to various components needed for preparing and carrying out such monitoring, and to methods of making these components.
    Type: Grant
    Filed: March 23, 1987
    Date of Patent: November 15, 1988
    Assignee: Abbott Laboratories
    Inventor: John C. Russell
  • Method for determining lipids
    Patent number: 4784945
    Abstract: A method for determining lipids using thin layer chromatography and multiple enzymatic staining is described. The method uses a hydrolase enzyme, an oxidase enzyme and a peroxidase enzyme in the presence of a chromogen precursor to form an oxidized chromogen stain. The method is particularly useful in determining phospholipids from animal and human tissue and/or fluids.
    Type: Grant
    Filed: October 30, 1986
    Date of Patent: November 15, 1988
    Assignee: Board of Governors of Wayne State University
    Inventors: Joseph D. Artiss, Dennis Bozimowski, Robert J. McEnroe, Bennie Zak
  • Fetal pulmonary maturity test
    Patent number: 4547464
    Abstract: A quick and inexpensive test for the detection of fetal pulmonary maturity comprising the steps of acidifying a given volume of amniotic fluid, adding a given volume of an ether, agitating and observing the number of bubbles existing in the ether layer. The number of bubbles existing in the ether layer after a certain observational period may be correlated with the existence of pulmonary immaturity in a fetus.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: October 15, 1985
    Inventor: Michael Socol